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Dynamic modeling and simulation of irregular faults in axle box bearings of high-speed trains
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作者 Xiaohui GU Yajia WANG +2 位作者 Pengfei LIU Zechao LIU Shaopu YANG 《Applied Mathematics and Mechanics(English Edition)》 2025年第10期1883-1902,共20页
Axle box bearings are critical components of high-speed trains.Localized defects,such as pitting and spalling,on raceways or rollers pose significant threats to the operational safety of railway vehicles.In this work,... Axle box bearings are critical components of high-speed trains.Localized defects,such as pitting and spalling,on raceways or rollers pose significant threats to the operational safety of railway vehicles.In this work,a novel bearing-flexible axle boxvehicle coupling model is established to explore the vibration characteristics of axle box bearings with irregular localized defects.First,based on the contact and kinematic relationship between rollers and raceways,the three-dimensional(3D)bearing force elements are analyzed and formulated.Second,the established model and a flexible axle box are integrated into the vehicle,and the responses of the normal and faulty bearings under the combined excitations of wheel roughness and track irregularities are simulated.Third,the simulation results are verified through a rolling-vibrating test bench for full-scale wheelsets of high-speed trains.The comparisons of the fault-induced repetitive transients in the time-domain and the fault characteristic frequencies in the envelope spectra demonstrate the efficiency of the proposed model.Finally,based on the flexible axle box model,a sensitivity analysis of the accelerometer placements to the bearing faults is carried out,and the optimal one is identified based on both the time-domain and frequency-domain signal-to-noise ratios(SNRs)for engineering applications. 展开更多
关键词 axle box bearing irregular fault track irregularity flexible axle box accelerometer placement selection
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A clip-on composite sensor based packaging design method for fiber Bragg grating axle counter
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作者 Mengyao Zhao Xueyun Cao +2 位作者 Longsheng Wang Yang Peng Tao Wang 《Railway Sciences》 2025年第5期647-665,共19页
Purpose–To address the encapsulation challenge of fiber Bragg grating(FBG)sensors in complex railway environments,this paper designs a clip-on composite sensor enabling installation-friendly deployment and long-term ... Purpose–To address the encapsulation challenge of fiber Bragg grating(FBG)sensors in complex railway environments,this paper designs a clip-on composite sensor enabling installation-friendly deployment and long-term axle counting system monitoring.Design/methodology/approach–Wheel–rail mechanical behavior was simulated via finite element analysis(FEA)to determine optimal sensor placement.A clip-on composite sensor was subsequently engineered.Stress transduction efficacy was validated through FEA quantification of stress responses at the axle counter location.Findings–The proposed FBG axle counter integrates temperature compensation and anti-detachment monitoring as well as advantages such as simplified installation with minimal maintenance and sustained operational reliability.It effectively transmits stress,yielding a measured strain of 39μe under static loading conditions without sensitivity-enhancing elements.Originality/value–This study performs FEA of wheel-rail stress distribution and engineers the dual-slot composite sensor,FEAwas conducted to quantify the stress magnitude at the axle sensor position of the dual-slot composite sensor.Additionally,FEA was performed on sensors with different structural configurations,including adjustments to the axle sensor position,number of slots and axle position.The results confirmed that the designed composite sensor exhibits superior stress transfer characteristics. 展开更多
关键词 Fiber Bragg grating axle counting Finite element Sensor Wheel-rail forces
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Lightweight Design of Front Axle Structure of a Certain Type of Automobile
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作者 Chuan qi LI Jian ZOU +2 位作者 Bing Ll Yiming LEI Mingshuo ZHANG 《Mechanical Engineering Science》 2025年第1期26-32,共7页
In this paper,the front axle of a certain model is taken as the research object,and the stress and deformation of the frontaxle under three typical working conditions are analyzed by finite element technology.Based on... In this paper,the front axle of a certain model is taken as the research object,and the stress and deformation of the frontaxle under three typical working conditions are analyzed by finite element technology.Based on the simulation results,the 3D model of the front axle was optimized,and the finite element analysis of the optimized structure of the front axle under three typical working conditions was carried out to verify the correctness of the model.Finally,the fatigue tool module of ANSYS Workbench was used to analyze the fatigue life of the front axle under the optimized emergency conditions,and the feasibility of the model was verified.The analysis data shows that the design of the front axle components still has a lot of potential for lightweighting,and the weight of the front axle can be reduced by 6.73%through optimization,and the performance of the front axle can also meet the needs of use.The research conclusionhas a certain reference value for the lightweight design of automobile front axle. 展开更多
关键词 automobile front axle structural optimization Fatigue life
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An estimating methodology for the load of train axle box bearings
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作者 Zhenqian Li Maoru Chi +1 位作者 Wubin Cai Yabo Zhou 《High-Speed Railway》 2025年第4期267-280,共14页
Axle box bearings serve as crucial components within the transmission system of high-speed trains.Their failure can directly impact the operational safety of these trains.Accurately determining the dynamic load experi... Axle box bearings serve as crucial components within the transmission system of high-speed trains.Their failure can directly impact the operational safety of these trains.Accurately determining the dynamic load experienced by bearings during the operation of high-speed trains can provide valuable boundary inputs for the study of bearing fatigue life and service performance,thereby holding significant engineering implications.In this study,we propose a high-speed train axle box bearing load estimation method(FMCC-DKF).This method is founded on the Kalman filtering technique of the Maximum Correntropy Criterion(MCC)and employs dummy measurement technology to enhance the stability of estimated loads.We develop a kernel size update algorithm to address the challenges associated with obtaining the key parameter,kernel size of MCC.Comparative analysis of the vertical and lateral loads of the axle box bearing obtained using FMCC-DKF,DKF,and AMCC-DKF,under both measurement noise-free and non-Gaussian noise conditions,is conducted to demonstrate the superiority of the proposed estimation method.The results indicate that the proposed FMCC-DKF method exhibits high estimation accuracy under both measurement noise-free and non-Gaussian noise interference,and maintains its high estimation accuracy despite changes in train speed.The proposed load estimation method demonstrates reliable performance within the low-frequency domain below 70 Hz. 展开更多
关键词 axle box bearing load Load estimation Maximum correntropy criterion Non-Gaussian noise High-speed train
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Damage Tolerance Assessment of Heavy-Duty Freight Railway Axles with Artificial Defects
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作者 Hai Zhao Ding Liao +4 位作者 Jiewei Gao Shunpeng Zhu Ligen Liu Jing Han Shantong Li 《Chinese Journal of Mechanical Engineering》 2025年第2期394-406,共13页
Heavy-duty freight railway axles are no less important than those of passenger trains,owing to the potentially catastrophic results caused by the derailment of trains carrying hazardous substances.Intrinsic and extrin... Heavy-duty freight railway axles are no less important than those of passenger trains,owing to the potentially catastrophic results caused by the derailment of trains carrying hazardous substances.Intrinsic and extrinsic imperfections challenge classical design theories built based on the safe life concept,and damage tolerance assessment becomes vital for the safety and reliability of long-term serviced railway axles,as pits and scratches are common defects for heavy-duty railway axles.In this work,four-point rotating bending fatigue tests of AAR-CM railway axle steel specimens with semicircular and circumferential groove notches are conducted.The fatigue limit of the semicircular notched specimens was evaluated based on fracture mechanics theory,in which non-conservative results are obtained by the El Haddad model and the S–N curves of circumferential groove notched specimens are correlated by the theory of critical distance(TCD). 展开更多
关键词 Heavy-duty railway axle Damage tolerance NOTCH K-T diagram Theory of critical distance
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受体酪氨酸激酶AXL在宫颈癌中的表达及临床意义
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作者 张大贵 韩玲 +2 位作者 林小芳 张普 张曦 《浙江医学》 2025年第24期2597-2603,共7页
目的分析受体酪氨酸激酶AXL在宫颈癌组织中的表达差异,并探讨其表达水平对患者预后的影响。方法收集癌症基因组图谱中宫颈鳞状细胞癌(CESC)数据集,使用ROC曲线分析AXL基因表达水平鉴别CESC的效能;使用Kaplan-Meier生存曲线分析不同AXL... 目的分析受体酪氨酸激酶AXL在宫颈癌组织中的表达差异,并探讨其表达水平对患者预后的影响。方法收集癌症基因组图谱中宫颈鳞状细胞癌(CESC)数据集,使用ROC曲线分析AXL基因表达水平鉴别CESC的效能;使用Kaplan-Meier生存曲线分析不同AXL基因表达水平CESC患者生存差异。回顾性收集2021年1月至2024年1月温州医科大学附属第二医院手术切除的经病理检查确诊的79例宫颈癌组织及癌旁组织,采用免疫组织化学染色法检测不同组织中AXL表达差异,比较AXL高表达组(41例)和低表达组(38例)患者临床病理特征。使用Cox回归分析影响宫颈癌患者预后的因素。绘制Kaplan-Meier生存曲线比较两组患者无病生存率和总生存率。结果AXL基因表达水平鉴别CESC组与正常组的AUC=0.923,具有较高诊断效能;AXL基因高表达患者10年无病生存率和10年总生存率均显著低于低表达组(均P<0.05)。相比癌旁组织,宫颈癌组织中AXL蛋白阳性率显著升高(P<0.05);AXL高表达组中年龄>55岁、肿瘤-淋巴结-转移(TNM)分期Ⅲ~Ⅳ期、盆腔淋巴结转移患者比例显著升高(均P<0.05)。Cox回归分析显示,远处转移、AXL高表达、盆腔淋巴结转移是宫颈癌患者预后影响因素(均P<0.05)。Kaplan-Meier生存曲线分析显示,AXL高表达组患者3年无病生存率和总生存率均显著低于AXL低表达组(均P<0.05)。结论宫颈癌组织中AXL高表达预示着更差的预后,提示AXL可作为宫颈癌预后评估的指标,具有潜在的生物标志物的价值。 展开更多
关键词 宫颈癌 受体酪氨酸激酶 axl 生存分析
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当归芍药散调控EPO/PPAR-γ/AXL通路增强小胶质细胞吞噬改善血管性认知障碍
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作者 李翔 袁宁宁 +2 位作者 徐莹 苏越 成小兰 《中国中西医结合杂志》 北大核心 2025年第6期706-713,共8页
目的 观察当归芍药散(DSS)对血管性认知障碍(VCI)大鼠认知功能和促红细胞生成素(EPO)/过氧化物酶体增殖物激活受体γ(PPAR-γ)/AXL受体酪氨酸激酶(AXL)/AXL通路的影响,探讨其作用机制。方法 将40只SD大鼠随机分为假手术组(Sham组)、模型... 目的 观察当归芍药散(DSS)对血管性认知障碍(VCI)大鼠认知功能和促红细胞生成素(EPO)/过氧化物酶体增殖物激活受体γ(PPAR-γ)/AXL受体酪氨酸激酶(AXL)/AXL通路的影响,探讨其作用机制。方法 将40只SD大鼠随机分为假手术组(Sham组)、模型组(VCI组)、模型+当归芍药散低剂量组(5 g/kg)、模型+当归芍药散高剂量组(10 g/kg)及模型+尼莫地平组(Nimodipine,NMP组,9.45 mg/kg),每组8只。除Sham组外,其余各组采用双侧颈总动永久性脉结扎法建立VCI模型,造模后立即给药干预,Sham组和模型组灌胃等量生理盐水,给药4周。采用Morris水迷宫测试大鼠学习记忆能力,HE染色检测大鼠海马组织损伤,牢固蓝染色(LFB)检测大鼠海马髓鞘损伤,免疫荧光染色检测大鼠小胶质细胞活化状态和髓鞘相关蛋白,荧光定量PCR检测小胶质细胞M2极化标志物和吞噬相关基因mRNA表达水平,ELISA检测炎症因子表达,Western Blot检测EPO通路相关蛋白表达。结果 与模型组比较,DSS高剂量组穿越平台次数增加,目标象限停留时间延长,逃逸潜伏期缩短(P<0.01)。ELISA检测结果显示,DSS高剂量组大鼠海马中炎症相关因子IL-6、TNF-α、单核细胞趋化蛋白1(MCP-1)降低(P<0.05)。荧光定量PCR结果显示,DSS高剂量组小胶质细胞M1极化标志物CD68表达下降,而M2极化标志物CD206、精氨酸酶1(Arg-1)表达升高(P<0.01,P<0.05)。Western Blot结果表明,DSS组EPO、PPAR-γ和AXL蛋白表达上调(P<0.01)。结论 DSS高剂量通过调控EPO/PPAR-γ/AXL通路增强海马小胶质细胞吞噬功能,并向M2型极化减轻神经炎症,进而改善VCI。 展开更多
关键词 血管性认知障碍 当归芍药散 小胶质细胞 促红细胞生成素 过氧化物酶体增殖物激活受体Γ axl受体酪氨酸激酶 中药复方 中西医结合
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益母草碱调节GAS6/Axl信号通路对冠心病大鼠心肌损伤的影响 被引量:2
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作者 孟王桃 崔冬玲 +2 位作者 吴冬景 陈超 张颖颖 《中国药房》 北大核心 2025年第1期51-56,共6页
目的探讨益母草碱对生长停滞特异性蛋白6(GAS6)/酪氨酸蛋白激酶受体(Axl)信号通路的影响,阐明其减轻冠心病大鼠心肌损伤的机制。方法构建冠心病大鼠模型,将造模成功的大鼠按随机抽样方法分为模型组,益母草碱低、高剂量组(分别灌胃25、10... 目的探讨益母草碱对生长停滞特异性蛋白6(GAS6)/酪氨酸蛋白激酶受体(Axl)信号通路的影响,阐明其减轻冠心病大鼠心肌损伤的机制。方法构建冠心病大鼠模型,将造模成功的大鼠按随机抽样方法分为模型组,益母草碱低、高剂量组(分别灌胃25、100 mg/kg益母草碱+腹腔注射75 mg/kg生理盐水),益母草碱高剂量+GAS6/Axl信号通路抑制剂组(灌胃100 mg/kg益母草碱+腹腔注射75 mg/kg的R428),每组12只;另取12只正常大鼠作对照组。各给药组大鼠给予相应药物,对照组和模型组大鼠灌胃并腹腔注射等体积生理盐水,每天1次,连续48 d。给药结束后,检测大鼠心功能和血清中炎症因子及心肌损伤标志物水平;观察其心肌组织病理形态;检测其心肌组织细胞凋亡率和心肌组织中凋亡及GAS6/Axl信号通路相关蛋白表达。结果与对照组比较,模型组大鼠出现心肌细胞与心肌纤维排列紊乱、心肌细胞肥大、细胞核固缩等病变,左室射血分数、左室短轴缩短率、二尖瓣环舒张早期与舒张晚期运动速度之比及GAS6蛋白相对表达量和B细胞淋巴瘤2/B细胞淋巴瘤2相关X蛋白、磷酸化Axl/Axl比值均显著降低(P<0.05),肿瘤坏死因子α、白细胞介素1β、白细胞介素6、肌酸激酶同工酶、肌钙蛋白Ⅰ、肌红蛋白水平以及心肌组织细胞凋亡率和剪切型胱天蛋白酶3/胱天蛋白酶3比值均显著升高(P<0.05);益母草碱各剂量组大鼠上述病理情况及各检测指标均显著改善(P<0.05),且益母草碱高剂量组效果较益母草碱低剂量组明显(P<0.05);R428处理可逆转高剂量益母草碱对冠心病大鼠心肌损伤的改善作用(P<0.05)。结论益母草碱可减轻冠心病大鼠心肌损伤,其作用机制可能与激活GAS6/Axl信号通路相关。 展开更多
关键词 益母草碱 GAS6/axl信号通路 冠心病 心肌损伤
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Analysis of Quenching Stresses in 35CrMo Axle 被引量:2
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作者 龚海 WU Yunxin +1 位作者 FENG Xiaolei LI Yihua 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2016年第3期630-635,共6页
By using the finite element method (FEM), we comprehensively analyzed the fields of temperature, organization, and stress in 35CrMo train axles during the quenching process is conducted, and experimentally studied t... By using the finite element method (FEM), we comprehensively analyzed the fields of temperature, organization, and stress in 35CrMo train axles during the quenching process is conducted, and experimentally studied the formation and evolution of inner stresses in axles during the quenching process. The results show that in the quenching process, stresses on the axle surface change from tensile to compressive gradually, while stresses in the axle core change from compressive to tensile gradually. Heat stresses and the amount of martensitic transformation are all increased with the increase of cooling rate. As a result, the maximmn instantaneous stresses in the axle are increased greatly when the cooling rate is increased with brine quenching. Large instantaneous tensile stress in the axle core with brine quenching is very likely to cause quench cracking and should be avoided. 展开更多
关键词 35CrMo axle QUENCHING residual stress FEM X-ray diffraction
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Analysis and Optimization on Factors Affecting Forming Quality of Half Axle Gears Warm Precision Forging 被引量:2
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作者 WANG Menghan CHEN Xihou ZHOU Jie 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2010年第1期110-114,共5页
Half axle gears is produced by precision forging popularly because of the advantages in minimum machining allowances, lower material consumption and good service properties. But the forming quality of precision forgin... Half axle gears is produced by precision forging popularly because of the advantages in minimum machining allowances, lower material consumption and good service properties. But the forming quality of precision forging is difficult to control. Many simulations and analysis of precision forging process were taken by previous researchers. But no concrete method is proposed to evaluate and optimize the forming quality of half axel gears. The primary purpose of this work is improving the forming quality of half axel gears by analyzing and optimizing the affected factors of forming quality. The enclosed-die warm forging process of half axle gears was developed, and a new type of die-set used on double action hydraulic press was brought forward. The main influential factors of precision forming quality were analyzed after the forming process had been simulated by using finite element method(FEM). These factors include die structure, web thickness and web position. A method used to evaluate the forming quality was established, which investigated the maximal forming load, the metal filling rate and the material damage factor. The FEM simulations of half axle gears precision forging were evaluated by this method. The results show that the best forming quality can be achieved when the punches were added with bosses, the web located at the middle plant of the gear, and the web thickness was 30 percent of the inner hole diameter. Verification experiments taking the above optimized parameters were performed on a 7.8 MN double action hydraulic press. The trial products were formed well. And their geometric precision meets the demand. The verification result shows that the optimization of the influential factors, according to the simulations and the evaluation method, can improve the forming quality. The new structure of precision forging die-set and the new evaluation method guarantee a high forming quality ofhalfaxel gears. 展开更多
关键词 warm precision forging half axle gears forming quality die structure WEB
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DAMAGE TOLERANCE ANALYSIS ON HOLLOW AXLES OF HIGH SPEED MOTOR TRAINS 被引量:2
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作者 ZHOU Suxia XIE Jilong +1 位作者 YANG Guangxue XIAO Nan 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2008年第5期8-12,共5页
According to the rules of UIC515-3,the service loads of the axles are defined,which include some different loads cases as follows:the static loads;the impact loads resulted from running through the rail joints and une... According to the rules of UIC515-3,the service loads of the axles are defined,which include some different loads cases as follows:the static loads;the impact loads resulted from running through the rail joints and unevenness rails;the loads through curves and from braking.Through the calculating and analysis,the stress distribution of the hollow axles is obtained for 200 km/h high speed motor trains used in China.At the same time,the fatigue crack growth of hollow axles is studied,and the initial surface cracks of 2 mm depth caused by hard objects strike or the other causes are discussed.On the basis of the linear elastic fracture mechanics theory,the stress intensity factor of the crack of the geometry transition outside the wheel seat is also studied.Associated with fatigue crack propagation equation and the corresponding crack propagation threshold,the crack propagation characteristics under different shapes are calculated.Then the running distances are educed with different shapes propagating to the critical length,and the estimation of the residual lives about hollow axles which are the reference values of examine and repair limit of the hollow axle is given. 展开更多
关键词 Motor wains Hollow railway axles Fatigue crack axle stress Damage tolerance Loads
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Fatigue Properties Improvement of Low-Carbon Alloy Axle Steel by Induction Hardening and Shot Peening:A Prospective Comparison 被引量:5
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作者 G.C.Chu F.Z.Hu +4 位作者 X.J.jin Y.Zhang Q.Wang J.P.Hou Z.F.Zhang 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2022年第8期1343-1356,共14页
Fatigue fracture is the major threat to the railway axle, which can be avoided or delayed by surface strengthening. In this study, a low-carbon alloy axle steel with two states was treated by surface induction hardeni... Fatigue fracture is the major threat to the railway axle, which can be avoided or delayed by surface strengthening. In this study, a low-carbon alloy axle steel with two states was treated by surface induction hardening and shot peening, respectively, to reveal the mechanism of fatigue property improvement by microstructure characterization, microhardness measurement, residual stress analysis, roughness measurement, and rotary bending fatigue tests. The results indicate that both quenching and tempering treatment can effectively improve the fatigue properties of the modified axle steel. In addition, induction hardening can create an ideal hardened layer on the sample surface by phase transformation from the microstructure of ferrite and pearlite to martensite. By comparison, shot peening can modify the microstructure in surface layer by surface severe plastic deformation introducing a large number of dislocation and even cause grain refinement. Both induction hardening and shot peening create compressive residual stress into the surface layer of axle steel sample, which can effectively reduce the stress level applied to the metal surface during the rotary bending fatigue tests. On the whole, the contribution of induction hardening to the fatigue life of axle steel sample is better than that of the shot peening, and induction hardening shows obvious advantages in improving the fatigue life of axle steel. 展开更多
关键词 Surface strengthening Induction hardening Shot peening axle steel Fatigue property improvement
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Experimental and numerical study on fretting wear and fatigue of full-scale railway axles 被引量:14
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作者 Lang Zou Dongfang Zeng +3 位作者 Yabo Li Kai Yang Liantao Lu Caiqin Yuan 《Railway Engineering Science》 2020年第4期365-381,共17页
This study investigated the fretting wear and fatigue of full-scale railway axles.Fatigue tests were conducted on full-scale railway axles,and the fretting wear and fretting fatigue in the fretted zone of the railway ... This study investigated the fretting wear and fatigue of full-scale railway axles.Fatigue tests were conducted on full-scale railway axles,and the fretting wear and fretting fatigue in the fretted zone of the railway axles were analysed.Three-dimensional finite element models were established based on the experimental results.Then,multi-axial fatigue parameters and a linear elastic fracture mechanics-based approach were used to investigate the fretting fatigue crack initiation and propagation,respectively,in which the role of the fretting wear was taken into account.The experimental and simulated results showed that the fretted zone could be divided into zones I-III according to the surface damage morphologies.Fretting wear alleviated the stress concentration near the wheel seat edge and resulted in a new stress concentration near the worn/unworn boundary in zone II,which greatly promoted the fretting crack initiation at the inner side of the fretted zone.Meanwhile,the stress concentration also increased the equivalent stress intensity factor range DKeq below the mating surface,and thus promoted the propagation of fretting fatigue crack.Based on these findings,the effect of the stress redistribution resulting from fretting wear is suggested to be taken into account when evaluating the fretting fatigue in railway axles. 展开更多
关键词 Railway axle Fretting wear Fretting fatigue Crack initiation Crack propagation Finite element
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Vibration of Axle Box from Wheel Diameter Difference in Vehicle 被引量:3
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作者 CHENG Daolai XU Lei SUN Xiaojie 《Journal of Shanghai Jiaotong university(Science)》 EI 2020年第4期509-518,共10页
The wheel diameter difference would worsen the dynamic performance and affect the safety of the rail vehicle.Therefore,it is necessary to detect wheel diameter difference while the train is operating.However,several e... The wheel diameter difference would worsen the dynamic performance and affect the safety of the rail vehicle.Therefore,it is necessary to detect wheel diameter difference while the train is operating.However,several existing detection methods can’t accurately detect and diagnose the wheel diameter difference under highspeed running environment.In this study,a new method of detecting wheel diameter difference was proposed for high speed rail vehicle.The wheel diameter difference would be diagnosed by the amplitude and frequency of vibration impact on the axle box.Firstly,the dynamic model with varying wheel diameters was established in SIMPACK,and LMA tread was used in high-speed rail vehicles.Then,the simulation results of rail vehicle dynamic performance were compared under different wheel diameter differences.After that,the relationship between axle box vibration and wheel diameter difference was used to demonstrate the feasibility of this detection technology.Finally,comparing and analyzing the simulation results of vibration obtained by matching treads with different wheel diameters,it shows that by increasing the wheel diameter difference,the longitudinal and lateral impacts on axle boxes increase asymmetrically,and the amplitude and the frequency become more evident.Therefore,this paper presents a technical scheme of online measuring wheel diameter difference by monitoring the vibration of the axle box. 展开更多
关键词 wheel diameter difference axle box dynamic simulation vibration characteristics
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Effect of Nb addition on microstructure and mechanical properties of 25CrNiMoV(DZ2)steel for high-speed railway axles 被引量:1
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作者 Jin-wen Zhang Yan-guang Cao +2 位作者 Cheng-guo Zhang Zhao-dong Li Wen-xian Wang 《Journal of Iron and Steel Research International》 SCIE EI CSCD 2022年第5期802-809,共8页
The microstructure,precipitates and properties of 25CrNiMoV(DZ2)steel for high-speed railway axles with different Nb contents were investigated by means of optical microscopy,scanning electron microscopy,electron back... The microstructure,precipitates and properties of 25CrNiMoV(DZ2)steel for high-speed railway axles with different Nb contents were investigated by means of optical microscopy,scanning electron microscopy,electron back-scattering diffraction,transmission electron microscopy and physicochemical phase analysis.The results show that the grain size of the original austenite of the test steels decreases from 20.5 to 14.2 and 10.8μm after adding 0.026 and 0.039 wt.%Nb to a 25CrNiMoV steel,respectively.Moreover,the block width of the tempered martensite in the test steels is refined from 1.91 to 1.72 and 1.60µm,respectively.MC-type precipitates in 25CrNiMoV steel are mainly VC,while(Nb,V)C gradually precipitates when Nb is microalloyed,and the amount of precipitates increases with increasing Nb content.Through strengthening mechanism analysis,it is found that grain refinement strengthening is the primary way to increase the strength.The improvement in the yield strength with increasing Nb content is attributed to a significant increase in precipitation strengthening,grain refinement strengthening and dislocation strengthening. 展开更多
关键词 High-speed railway axle steel Nb microalloying PRECIPITATE Strengthening mechanism
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Seismic and Geological Model of Jura Sedimentation from the South-West Part of Tarskii Axle Part
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作者 Boykov Stanislav 《地学前缘》 EI CAS CSCD 北大核心 2009年第S1期138-138,共1页
Seismic attributes have proliferated in the last three decades at a rapid rate and have helped interpreters in making accurate predictions in hydrocarbon exploration and development.Attributes sensitive to amplitude, ... Seismic attributes have proliferated in the last three decades at a rapid rate and have helped interpreters in making accurate predictions in hydrocarbon exploration and development.Attributes sensitive to amplitude, such as impedance inversion and AVO,are widely used for lithological and petrophysical prediction of reservoir properties.Other attributes,such as coherence and curvature,are particularly useful 展开更多
关键词 axle SEISMIC faults fracture volumetric attributes
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Dynamic Characteristics Analysis on Truck Drive Axle Assembly
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作者 Wang Fengyuan Han Longhai Zhang Mengmeng 《仪器仪表学报》 EI CAS CSCD 北大核心 2013年第S1期153-158,共6页
A kind of single impulse welding drive axle used in a truck was selected as research object.The dynamic characteristic simulation of the drive axle was analyzed through building the vehicle dynamics simulation model i... A kind of single impulse welding drive axle used in a truck was selected as research object.The dynamic characteristic simulation of the drive axle was analyzed through building the vehicle dynamics simulation model in virtual software.Comparison between different speeds and different roads were made to get the corresponding dynamics of drive axle. 展开更多
关键词 DRIVE axle ASSEMBLY DYNAMIC CHARACTERISTICS model
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DEVELOPMENT OF MATERIAL USED FOR AVIATION APPARATUS AXLE JOURNALS
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作者 Wu Enxi, Li Shen, Qian Chongliang and Zou ZhiqiangState Key Laboratory for Powder Metallurgy, Central South University of Technology, Changsha 410083, P. R. China 《中国有色金属学会会刊:英文版》 CSCD 1998年第2期19-24,共6页
DEVELOPMENTOFMATERIALUSEDFORAVIATIONAPPARATUSAXLEJOURNALS①WuEnxi,LiShen,QianChongliangandZouZhiqiangStateKey... DEVELOPMENTOFMATERIALUSEDFORAVIATIONAPPARATUSAXLEJOURNALS①WuEnxi,LiShen,QianChongliangandZouZhiqiangStateKeyLaboratoryforPowd... 展开更多
关键词 Co25W ALLOY axle JOURNALS consumableelectrode MELTING WIREDRAWING agehardening
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当归六黄汤通过激活Tyro3/Axl受体活性治疗桥本甲状腺炎大鼠的实验研究 被引量:1
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作者 吴静泽 王晔恺 +1 位作者 陈位 金丹雯 《浙江中西医结合杂志》 2025年第3期200-204,共5页
目的探讨当归六黄汤治疗桥本甲状腺炎大鼠的可能作用机制。方法24只雄性大鼠适应性喂养1周后,按随机数字表法分为空白组、模型组、安慰剂组及当归六黄汤组,每组6只。空白组不予任何处理直接处死。模型组、安慰剂组和当归六黄汤组大鼠通... 目的探讨当归六黄汤治疗桥本甲状腺炎大鼠的可能作用机制。方法24只雄性大鼠适应性喂养1周后,按随机数字表法分为空白组、模型组、安慰剂组及当归六黄汤组,每组6只。空白组不予任何处理直接处死。模型组、安慰剂组和当归六黄汤组大鼠通过在尾根和足垫皮下注射甲状腺球蛋白各100μg,每周1次,持续7周,建立桥本甲状腺炎模型。从第8周开始,安慰剂组和当归六黄汤组分别予安慰剂(40 g/L)和当归六黄汤水煎液(144 g/L)灌胃,每次2 mL,每天1次。第11周处死模型组、安慰剂组和中药组所有大鼠,采集血液和甲状腺组织。CT检测大鼠甲状腺组织肿胀情况,流式细胞术检测外周血CD3^(+)T细胞表面Tyro3、Axl的平均荧光强度(MFI),酶联免疫吸附试验(ELISA)检测血清抗甲状腺球蛋白抗体(TG-Ab)和抗甲状腺过氧化物酶抗体(TPO-Ab)水平,免疫组化检测甲状腺组织Tyro3和Axl表达,实时荧光定量PCR检测甲状腺组织Tyro3、Axl、B细胞淋巴瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)mRNA表达。结果与模型组和安慰剂组比较,中药组CT下可见甲状腺组织炎性减退,边界逐渐清晰。与空白组比较,模型组血清TG-Ab[(79.77±6.06)U/mL比(43.00±9.36)U/mL,P<0.01]、TPO-Ab[(8.04±0.99)U/mL比(2.76±1.11)U/mL,P<0.01]及甲状腺组织Bax mRNA[(1.39±0.09)比(0.27±0.11),P<0.01]表达均升高,甲状腺组织Bcl-2 mRNA[(1.29±0.14)比(3.39±0.37),P<0.01]表达降低。与模型组和安慰剂组比较,当归六黄汤组血清TG-Ab[(43.69±11.51)U/mL比(79.77±6.06)U/mL、(82.17±12.11)U/mL,P<0.01]、TPO-Ab[(3.02±0.73)U/mL比(8.04±0.99)U/mL、(7.84±0.79)U/mL,P<0.01]及甲状腺组织Bax mRNA[(0.24±0.10)比(1.39±0.09)、(1.38±0.34),P<0.01]表达均降低,甲状腺组织Bcl-2 mRNA表达升高[(2.89±0.32)比(1.29±0.14)、(1.36±0.29),P<0.01]。与空白组比较,模型组外周血CD3^(+)T细胞Tyro3、Axl MFI[Tyro3:(1325.53±129.45)比(1775.95±120.73),Axl:(130.10±11.71)比(156.58±9.27),P<0.01]及甲状腺组织Tyro3、Axl mRNA[Tyro3:(0.67±0.13)比(3.06±0.23),Axl:(0.14±0.05)比(0.71±0.17),P<0.01]和平均光密度(AOD)[Tyro3:(119.45±14.47)比(266.20±33.21),Axl:(117.96±13.06)比(240.06±21.50),P<0.01]均降低。与模型组和安慰剂组比较,当归六黄汤组外周血CD3^(+)T细胞Tyro3、Axl MFI[Tyro3:(1769.92±151.90)比(1325.53±129.45)、(1241.57±193.40),Axl:(150.08±15.32)比(130.10±11.71)、(127.50±9.94),P<0.01]及甲状腺组织Tyro3、Axl mRNA[Tyro3:(2.69±0.44)比(0.67±0.13)、(0.71±0.33),Axl:(0.62±0.10)比(0.14±0.05)、(0.12±0.04),P<0.01]和AOD[Tyro3:(251.41±32.28)比(119.45±14.47)、(115.69±24.81),Axl:(223.23±19.12)比(117.96±13.06)、(119.69±20.48),P<0.01]均升高。结论当归六黄汤对桥本甲状腺炎大鼠的抑制效果可能和激活Tyro3/Axl受体信号通路进而引起凋亡抑制有关。 展开更多
关键词 大鼠 桥本甲状腺炎 当归六黄汤 Tyro3/axl受体 B细胞淋巴瘤-2 B细胞淋巴瘤-2相关X蛋白
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甲基莲心碱调节Gas6/Axl信号通路对带状疱疹后遗神经痛小鼠疼痛反应的影响
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作者 雷剑 黄丹 葛兴森 《河北医学》 2025年第11期1801-1808,共8页
目的:探究甲基莲心碱(NEF)调节生长停滞特异性蛋白6(Gas6)/酪氨酸蛋白激酶受体(Axl)信号通路对带状疱疹后遗神经痛(PHN)小鼠疼痛反应的影响。方法:构建PHN小鼠模型。建模成功的小鼠随机分成PHN组、NEF-L组(5mg/kg)、NEF-M组(10mg/kg)、N... 目的:探究甲基莲心碱(NEF)调节生长停滞特异性蛋白6(Gas6)/酪氨酸蛋白激酶受体(Axl)信号通路对带状疱疹后遗神经痛(PHN)小鼠疼痛反应的影响。方法:构建PHN小鼠模型。建模成功的小鼠随机分成PHN组、NEF-L组(5mg/kg)、NEF-M组(10mg/kg)、NEF-H组(20mg/kg)、R428组(20mg/kg和125mg/kg Gas6/Axl信号通路抑制剂R428),NEF和R428均通过腹腔注射给药,每组各10只。另选取10只正常C57BL/6J小鼠作为对照组(NC组)。检测各组小鼠痛阈值及自发缩足反射次数;HE染色观察脊髓组织病理变化;ELISA检测小鼠脊髓组织炎症因子、前列腺素E2(PGE2)、5-羟色胺(5-HT)、P物质(SP)表达水平;TUNEL观察小鼠脊髓神经细胞凋亡;六胺银染色观察小鼠脊髓组织形态学改变;Western blot检测小鼠脊髓组织Gas6/Axl信号通路及凋亡相关蛋白表达。结果:PHN组小鼠脊髓组织及神经元纤维结构损伤严重,自发缩足反射次数、IL-6、IL-1β、PGE2、5-HT、SP、神经元凋亡率、Bax表达显著高于NC组(P<0.05),机械痛阈值、热痛阈值、Gas6、p-Axl/Axl、Bcl-2显著低于NC组(P<0.05);NEF-L组、NEF-M组、NEF-H组小鼠脊髓组织及神经元纤维结构损伤减轻,自发缩足反射次数、IL-6、IL-1β、PGE2、5-HT、SP、神经元凋亡率、Bax表达低于PHN组(P<0.05),机械痛阈值、热痛阈值、Gas6、p-Axl/Axl、Bcl-2高于PHN组(P<0.05);R428组小鼠脊髓组织及神经元纤维结构损伤加重,自发缩足反射次数、IL-6、IL-1β、PGE2、5-HT、SP、神经元凋亡率、Bax表达显著高于NEF-H组(P<0.05),机械痛阈值、热痛阈值、Gas6、p-Axl/Axl、Bcl-2显著低于NEF-H组(P<0.05)。结论:NEF能够改善PHN小鼠疼痛以及炎症反应,可能与激活Gas6/Axl信号通路密切相关。 展开更多
关键词 带状疱疹后遗神经痛 甲基莲心碱 生长停滞特异性蛋白6/酪氨酸蛋白激酶受体信号通路 疼痛反应
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