目的:揭示草乌煎煮时间、给药剂量与毒性的相关性。方法:采用均匀设计的方法,将草乌分别煎煮15 m in、30 m in、1 h、2 h、3 h、4 h、6 h,生药含量依次为临床用量的6倍、12倍、24倍、48倍、72倍、96倍、120倍。模型组和给药组于复制痹...目的:揭示草乌煎煮时间、给药剂量与毒性的相关性。方法:采用均匀设计的方法,将草乌分别煎煮15 m in、30 m in、1 h、2 h、3 h、4 h、6 h,生药含量依次为临床用量的6倍、12倍、24倍、48倍、72倍、96倍、120倍。模型组和给药组于复制痹证动物模型后,按组给药30 d。观测动物生长发育、血液学、血液生化学、脏器系数、病理组织学变化,及停药15 d后上述指标的变化。将结果进行多元回归分析,得出草乌煎煮时间、剂量与毒性的相关性。结果:草乌水煎液具有抗炎镇痛作用;对模型动物的生长发育无明显影响;对其造血系统无明显毒性;对其肝脏、肾脏、心脏有一定毒性。毒性最大的煎煮时间和给药剂量是30 m in、120倍,药效最佳的煎煮时间和给药剂量也是30 m in、120倍。结论:煎煮30 m in,给药剂量为临床用量120倍时,草乌水煎液对痹证动物产生的毒性最大,同时药效最佳。展开更多
Cambodia was one of the earliest ancient civilizations emerging in Southeast Asia.Under the influence of Brahmanism and Buddhism originating from India as well as the indigenous religious practices of mountain worship...Cambodia was one of the earliest ancient civilizations emerging in Southeast Asia.Under the influence of Brahmanism and Buddhism originating from India as well as the indigenous religious practices of mountain worship,the rulers of the Funan(扶南),Chenla(真腊,Kmir)and Wuge(吴哥,Angkor)often relied on the power of religion to indoctrinate and regulate secular society.In order to meet the practical needs of governing,its ancient rulers formed a system of religious belief that was centered around the“divine power”of Raksasdeva(Heavenly-king,天王),Devarāja(God-king,神王)and Buddharāja(Buddha-king,佛王).After examining Cambodia's ancient history,the rulers of Funan of ancient Cambodia discovered and developed a religious tradition of worshipping the heavenly deities on a sacred mountain near the capital city and then combined this ceremony with the use of the theocratic concept of“the divine protection of the kings”in an attempt to establish the legitimacy and divinity of their secular political power.During the interaction between politics and religion,the rulers of Chenla and Angkor continued to use religious belief as a means of strengthening the connection between its kings'political power and“divine authority”.Later,King JayavarmanⅡused the exchange of identities between the deities and kings and the tenet of“the divine power of the kings”contained within the Ritual of the Devarāja(God-King Ceremony)as the foundation for constructing a secular order which integrated the identities of its kings with deities and merged king's power with the authority of the gods.With the gradual decline of Angkor's national power,the belief in Devarāja and Buddharāja,which had helped earlier rulers to maintain social order,lost its practical effect.As a result,Cambodians gradually turned to Theravada Buddhism,which focused more on individual practice and self-liberation.展开更多
文摘目的:揭示草乌煎煮时间、给药剂量与毒性的相关性。方法:采用均匀设计的方法,将草乌分别煎煮15 m in、30 m in、1 h、2 h、3 h、4 h、6 h,生药含量依次为临床用量的6倍、12倍、24倍、48倍、72倍、96倍、120倍。模型组和给药组于复制痹证动物模型后,按组给药30 d。观测动物生长发育、血液学、血液生化学、脏器系数、病理组织学变化,及停药15 d后上述指标的变化。将结果进行多元回归分析,得出草乌煎煮时间、剂量与毒性的相关性。结果:草乌水煎液具有抗炎镇痛作用;对模型动物的生长发育无明显影响;对其造血系统无明显毒性;对其肝脏、肾脏、心脏有一定毒性。毒性最大的煎煮时间和给药剂量是30 m in、120倍,药效最佳的煎煮时间和给药剂量也是30 m in、120倍。结论:煎煮30 m in,给药剂量为临床用量120倍时,草乌水煎液对痹证动物产生的毒性最大,同时药效最佳。
基金the middle-stage research findings of the 2017 Major Grant of the Chinese National Social Sciences Fund titled “Social Life History of Chinese Buddhist Monks”(17ZDA233)
文摘Cambodia was one of the earliest ancient civilizations emerging in Southeast Asia.Under the influence of Brahmanism and Buddhism originating from India as well as the indigenous religious practices of mountain worship,the rulers of the Funan(扶南),Chenla(真腊,Kmir)and Wuge(吴哥,Angkor)often relied on the power of religion to indoctrinate and regulate secular society.In order to meet the practical needs of governing,its ancient rulers formed a system of religious belief that was centered around the“divine power”of Raksasdeva(Heavenly-king,天王),Devarāja(God-king,神王)and Buddharāja(Buddha-king,佛王).After examining Cambodia's ancient history,the rulers of Funan of ancient Cambodia discovered and developed a religious tradition of worshipping the heavenly deities on a sacred mountain near the capital city and then combined this ceremony with the use of the theocratic concept of“the divine protection of the kings”in an attempt to establish the legitimacy and divinity of their secular political power.During the interaction between politics and religion,the rulers of Chenla and Angkor continued to use religious belief as a means of strengthening the connection between its kings'political power and“divine authority”.Later,King JayavarmanⅡused the exchange of identities between the deities and kings and the tenet of“the divine power of the kings”contained within the Ritual of the Devarāja(God-King Ceremony)as the foundation for constructing a secular order which integrated the identities of its kings with deities and merged king's power with the authority of the gods.With the gradual decline of Angkor's national power,the belief in Devarāja and Buddharāja,which had helped earlier rulers to maintain social order,lost its practical effect.As a result,Cambodians gradually turned to Theravada Buddhism,which focused more on individual practice and self-liberation.
