The Smiles rearrangement is an exceptionally versatile method in organic synthesis,providing a broad canvas for designing cascade reactions that construct new Csp^(2)-Y(Y=C,O,N,S,CO,etc.)bonds.Among the various types ...The Smiles rearrangement is an exceptionally versatile method in organic synthesis,providing a broad canvas for designing cascade reactions that construct new Csp^(2)-Y(Y=C,O,N,S,CO,etc.)bonds.Among the various types of Smiles rearrangement,the radical-type variant has emerged as a more powerful,mild,efficient,and modern synthetic technique compared to its traditional ionic counterpart.This approach excels in generating new(hetero)aromatic migration products,enabling significant advancements in recent years.This tutorial review focuses on the recent progress,since 2016,in the development and application of radical Smiles rearrangement in organic chemistry.Special attention is paid to novel transformations achieved through photochemical,electrochemical,and transition metal catalysis methods.展开更多
Background:The Da Vinci Single-Port Robotic System(Da Vinci-SP),introduced by Intuitive(CA,USA)in 2018 in the USA and in 2024 in Europe,integrates advanced features like a flexible camera and articulating instruments....Background:The Da Vinci Single-Port Robotic System(Da Vinci-SP),introduced by Intuitive(CA,USA)in 2018 in the USA and in 2024 in Europe,integrates advanced features like a flexible camera and articulating instruments.It has garnered significant interest in urology.Our report presents the first described European series of Radical Prostatectomies using the Da Vinci SP at the leading Italian center,Istituto Nazionale Tumori di Napoli,IRCCS“G.Pascale”Foundation,detailing the technical differences and challenges faced by experienced multiport robotic surgeons.Methods:Sixteen patients have been enrolled and underwent Single-Port(SP)Robot-Assisted Radical Prostatectomy(SP-RARP).Baseline characteristics of the patients were collected.We provided a step-by-step description of the surgical technique.Oncological outcomes have been evaluated and compared with magnetic resonance imaging(MRI)and biopsy results.Intraoperative,perioperative,and postoperative complications,surgical outcomes,functional outcomes,and technical issues of the new system were also documented.Results:All surgeries were successfully performed without the need for conversion.An extraperitoneal approach was used for all patients.Median Console time was 110 min.No complications were reported.The estimated median blood loss was 175 cc.Discharge from the hospital was on the first post-operative day for all patients.Bladder catheter removal was on day 7 without the need for cystography.Conclusions:We presented the first European case series of SP-RARP,reporting our experience and confirming the procedure’s feasibility for a highly experienced robotic surgeon.Experience with an extraperitoneal approach using the multiport(MP)platform,combined with well-conducted training for the SP system,may facilitate the transition to SP surgery.Further procedures and studies are needed to evaluate the oncological and functional outcomes.展开更多
The radical addition/functional group migration strategy has emerged as a powerful tool for the difunctionalization of unsaturated hydrocarbons,yet the heteroatom-mediated functional group migration remains largely un...The radical addition/functional group migration strategy has emerged as a powerful tool for the difunctionalization of unsaturated hydrocarbons,yet the heteroatom-mediated functional group migration remains largely unexplored.Herein,we report an unprecedented radical difunctionalization of alkynes employing oxime esters as bifunctional reagents through a novel C-centered radical addition/N-centered radical translocation sequence.This innovative transformation paradigm enables efficient alkylamination of alkynes under mild photocatalytic redox conditions.Mechanistic investigations reveal a cascade sequence initiated by single-electron transfer from oxime derivatives,proceeding through radical addition,6-exo-trig cyclization,and subsequent imino group migration.展开更多
Selective depression of pyrite remains a major bottleneck in copper flotation,particularly when high-pyrite ores are processed and saline water is used.In such environments,conventional approaches using lime and inert...Selective depression of pyrite remains a major bottleneck in copper flotation,particularly when high-pyrite ores are processed and saline water is used.In such environments,conventional approaches using lime and inert grinding media often fail to discriminate ef-fectively between pyrite and valuable copper minerals due to strong copper activation on pyrite surfaces.This study introduced a novel approach using inorganic radicals generated from peroxymonosulfate(PMS)to selectively oxidize and depress pyrite.Flotation tests with synthetic high-pyrite ore blends showed that PMS significantly reduced pyrite recovery while maintaining or improving chalcopyrite flot-ation.Ethylenediaminetetraacetic acid(EDTA)extraction confirmed selective oxidation of pyrite,and electron paramagnetic resonance(EPR)spectroscopy identified hydroxyl(·OH)and sulfate(SO_(4)^(·-))radicals as the dominant reactive species.Iron ions from grinding me-dia and mineral surfaces were identified as key activators of PMS.A major insight was pyrite’s dual role,acting both as a radical scav-enger and an activator,which made it highly reactive and susceptible to radical-induced oxidation.This process converted surface copper-sulfur species into copper hydroxides,effectively suppressing pyrite flotation.While previous studies have applied EPR to detect radicals in simplified activator/precursor systems,this study provides the first direct mechanistic evidence of radical-driven selectivity in flotation by detecting inorganic radicals in a complex flotation slurry,thereby demonstrating their persistence under industrially relevant conditions and establishing a foundation for more effective and targeted flotation strategies.展开更多
Radical cycloaddition reactions(RCRs) are highly effective methods for constructing complex carbo-and heterocycles,which are frequently encountered in natural products that exhibit intriguing biological properties and...Radical cycloaddition reactions(RCRs) are highly effective methods for constructing complex carbo-and heterocycles,which are frequently encountered in natural products that exhibit intriguing biological properties and hold significant potential for applications in medicinal chemistry.Radical-mediated cycloaddition strategies,which recycle radical character,are particularly appealing because they require only a catalytic amount of reagent and promise reactions with theoretically high atom economy.This review focuses on recent developments and synthetic applications in RCRs,with an emphasis on visible lightinduced radical photocycloaddition reactions(RPCRs),transition metal-catalyzed approaches,and small molecule-catalyzed methods.By highlighting some outstanding innovations and addressing current challenges,this review aims to identify potential areas for improvement.These advancements will provide more efficient pathways for the synthesis of natural product molecules and offer valuable insights for the development of new synthetic methodologies.展开更多
Objective:To analyze the impact of nursing interventions based on quantitative assessment using the Kano model on the quality of rehabilitation in patients with early-stage ovarian cancer following laparoscopic radica...Objective:To analyze the impact of nursing interventions based on quantitative assessment using the Kano model on the quality of rehabilitation in patients with early-stage ovarian cancer following laparoscopic radical surgery.Methods:A prospective clinical study was conducted involving 96 patients with newly diagnosed early-stage ovarian cancer who underwent laparoscopic radical surgery from December 2023 to December 2025.Patients were randomly assigned to groups using a random number table method before surgery.After surgery,the control group(n=48)received routine quantitative assessment nursing interventions,while the observation group(n=48)received nursing interventions based on quantitative assessment using the Kano model.Both groups received continuous nursing care until discharge.Differences between the groups were compared in terms of negative emotions,quality of life scores before and after postoperative intervention,postoperative recovery indicators,and nursing satisfaction evaluations on the day of discharge.Results:After intervention,the observation group had lower scores on the Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS),as well as shorter recovery times for gastrointestinal function and food intake,and a shorter hospital stay compared to the control group.Additionally,the observation group had higher scores on the Quality-of-Life Instrument for Cancer Patients-Ovarian Cancer(QLICP-OV)than the control group,with statistically significant differences(p<0.05).The overall satisfaction with nursing care in the observation group was also higher than that in the control group,with a statistically significant difference(p<0.05).Conclusion:Implementing quantitative evaluation nursing interventions based on the Kano model for patients with early-stage ovarian cancer after laparoscopic radical surgery can,by addressing their postoperative basic health,disease awareness,and other intervention content needs to a comprehensive degree,actively promote postoperative recovery and improve their mental health and quality of life.展开更多
Photosynthesis of hydrogen peroxide(H_(2)O_(2))via oxygen reduction reaction(ORR)and water oxidation reaction(WOR)pathways requires controlled formation of radical intermediates.However,achieving precise control over ...Photosynthesis of hydrogen peroxide(H_(2)O_(2))via oxygen reduction reaction(ORR)and water oxidation reaction(WOR)pathways requires controlled formation of radical intermediates.However,achieving precise control over radical formation in metal-free catalysts remains challenging.Herein,we report a fluorinated COF(Kf-F-COF)featuring framework-bound carbonyl groups as intrinsic radical-generating sites for efficient dual-channel H_(2)O_(2)photosynthesis.This design enables the simultaneous activation of O_(2)and H_(2)O through radical-mediated hydrogen atom transfer processes.Mechanistic studies reveal that fluorination enhances the electron affinity of the carbonyl sites,facilitates diradical formation,and lowers the energy barriers of key reaction steps.As a result,Kf-F-COF achieves a high H_(2)O_(2)production rate of 6.42 mmol g^(-1)h^(-1)and long-term stability under natural sunlight and seawater conditions.This work presents a frameworkcentered radical strategy for dual-pathway H_(2)O_(2)photosynthesis and offers mechanistic insights into regulating COF-based photocatalysts.展开更多
Radical prostatectomy is a commonly used surgical method in cases of localized prostate cancer.In recent years,with the advent of new medical technologies and surgical techniques,the evolution of radical prostatectomy...Radical prostatectomy is a commonly used surgical method in cases of localized prostate cancer.In recent years,with the advent of new medical technologies and surgical techniques,the evolution of radical prostatectomy has revolutionized,especially in robot-assisted radical prostatectomy(RARP).The evolution of surgical approaches for radical prostatectomy has occurred in three stages:open surgery,laparoscopic intervention,and robot-assisted surgery.Regarding the functional recovery of patients who underwent laparoscopic radical prostatectomy or RARP,with the improvement of disease conditions,oncological prognosis of patients was not compromised.Particularly,RARP boasts distinguished novel techniques and approaches for maintaining urinary continence and sexual function in the short-and long-term.In addition,studies in the last two decades have shown its correlation with decreasing postoperative morbidity.In this paper,the available literatures related to the surgical approaches ranging from open surgery to RARP were reviewed,the superiority of any novel procedure was analyzed,and the advantages and disadvantages among the three modalities were compared,hoping to provide guidance to urologists when considering surgical approaches in the treatment of localized prostate cancer.展开更多
Oxalic acid salts(oxalate)were recently developed as C1 synthon,potent single-electron-transfer(SET)reductant,and hole scavengers via generation of CO_(2) and CO_(2) radical anion(CO_(2)·^(-))under mild photochem...Oxalic acid salts(oxalate)were recently developed as C1 synthon,potent single-electron-transfer(SET)reductant,and hole scavengers via generation of CO_(2) and CO_(2) radical anion(CO_(2)·^(-))under mild photochemical conditions.A series of challenging reductive transformations were realized with oxalic dianion under catalytic photoredox conditions or through an electron-donor-acceptor(EDA)complex formation process.As a chemical intermediate for carbon capture and utilization(also a cheap and readily available reagent),oxalate salts could release one electron easily(E_(ox)=+0.06 V vs.SCE)via visible-light irradiation to give CO_(2) and CO_(2)·^(-) and therefore opened a new arena for reductive carboxylation reactions with highly expanded reaction diversity and chemical space to realize challenging C-X bond activation,alkenes cross coupling,and reductive carboxylation of unsaturated chemical bonds in a more sustainable and efficient way.This review features the recently developed aspects with oxalate salts and also an outlook for its further application in organic radical transformations.展开更多
Objective:Radical prostatectomy(RP)is considered the gold standard treatment for patients with localized prostate cancer(PCa).All patients undergoing RP,either open,laparoscopic,or robotic,are at risk of developing ur...Objective:Radical prostatectomy(RP)is considered the gold standard treatment for patients with localized prostate cancer(PCa).All patients undergoing RP,either open,laparoscopic,or robotic,are at risk of developing urinary incontinence after RP.Our study aimed to analyze possible predictors of early postoperative(within 3 months)urinary continence(UC)outcomes following extraperitoneal single-site robot-assisted RP(ss-RARP)for localized PCa.Methods:We retrospectively reviewed data from 113 patients with localized PCa who were operated on by a highly experienced surgeon between September 2022 and December 2023.Patient characteristics(age,body mass index,prostate volume,prostate dimensions,preoperative and postoperative membranous urethral length,and percentage of membranous urethra removed)were analyzed using logistic regression to determine the independent factors contributing to short-term UC recovery after extraperitoneal ss-RARP.From the time of urinary catheter removal after surgery,the recovery of UC was followed up every month,and UC was defined as using≤1 safety pad daily,known as social continence.Results:The proportions of continent patients immediately after urinary catheter removal,1 month,and 3 months after extraperitoneal ss-RARP were 22%,49%,and 82%,respectively.The multivariate logistic regression analysis showed that the percentage of membranous urethra removed(p=0.016)and prostate volume(p=0.049)were associated with social UC recovery immediately after urinary catheter removal,and craniocaudal dimension of the prostate(p=0.042)and age(p=0.014)were associated with social UC recovery 1 month and 3 months after extraperitoneal ss-RARP,respectively.Conclusion:The percentage of membranous urethra removed,prostate volume,craniocaudal dimension of the prostate,and age are independent risk factors for social UC early after extraperitoneal ss-RARP.展开更多
The significant role of square root mapping in probability,statistics,physics,architecture and engineering motivates us to emphasize on a new radical functional equation arising from a square root and reciprocal squar...The significant role of square root mapping in probability,statistics,physics,architecture and engineering motivates us to emphasize on a new radical functional equation arising from a square root and reciprocal square root mappings.The interesting attribute of this equation is that it has both a square root mapping and a reciprocal square root mapping as solutions.We establish that the hyperstabilities of this equation exist using a fixed point alternative theorem.It is also demonstrated with an example that the stability may fail in special cases.展开更多
Harnessing bacteria for superoxide production in bioremediation holds immense promise,yet its practical application is hindered by slow production rates and the relatively weak redox potential of superoxide.This study...Harnessing bacteria for superoxide production in bioremediation holds immense promise,yet its practical application is hindered by slow production rates and the relatively weak redox potential of superoxide.This study delves into a cost-effective approach to amplify superoxide production using an Arthrobacter strain,a prevalent soil bacterial genus.Our research reveals that introducing a carbon source along with specific iron-binding ligands,including deferoxamine(DFO),diethylenetriamine pentaacetate(DTPA),citrate,and oxalate,robustly augments microbial superoxide generation.Moreover,our findings suggest that these iron-binding ligands play a pivotal role in converting superoxide into hydroxyl radicals by modulating the electron transfer rate between Fe(Ⅲ)/Fe(Ⅱ)and superoxide.Remarkably,among the tested ligands,only DTPA emerges as a potent promoter of this conversion process when complexed with Fe(Ⅲ).We identify an optimal Fe(Ⅲ)to DTPA ratio of approximately 1:1 for enhancing hydroxyl radical production within the Arthrobacter culture.This research underscores the efficacy of simultaneously introducing carbon sources and DTPA in facilitating superoxide production and its subsequent conversion to hydroxyl radicals,significantly elevating bioremediation performance.Furthermore,our study reveals that DTPA augments superoxide production in cultures of diverse soils,with various soil microorganisms beyond Arthrobacter identified as contributors to superoxide generation.This emphasizes the universal applicability of DTPA across multiple bacterial genera.In conclusion,our study introduces a promising methodology for enhancing microbial superoxide production and its conversion into hydroxyl radicals.These findings hold substantial implications for the deployment of microbial reactive oxygen species in bioremediation,offering innovative solutions for addressing environmental contamination challenges.展开更多
This article explored the application of dexmedetomidine(Dex),a highly selective alpha-2 agonist,in managing postoperative cognitive dysfunction(POCD)in elderly patients undergoing radical colon cancer surgery.Aging i...This article explored the application of dexmedetomidine(Dex),a highly selective alpha-2 agonist,in managing postoperative cognitive dysfunction(POCD)in elderly patients undergoing radical colon cancer surgery.Aging is associated with a progressive decline in physiological functions and an increased risk of adverse surgical outcomes,including POCD,which encompasses many neurocognitive disorders that manifest during the perioperative period.The aging population is at a higher risk for POCD,which can lead to prolonged hospital stays,delayed recovery,and increased healthcare costs.Dex has neuroprotective,opioid-sparing,and sympatholytic properties,which reduces the incidence and severity of POCD.Dex was introduced for sedation in patients receiving mechanical ventilation but has since been adopted in anesthesia due to its multifaceted benefits.Its appli-cation extends to sedation,analgesia,maintenance of anesthesia,and controlling delirium.Its neuroprotective and anti-inflammatory effects have been explored in managing POCD.This article discussed the broad range of patient and procedure-related risk factors for POCD.Early identification and intervention are crucial to prevent the progression of POCD,which can have severe physical,psychological,and economic consequences.The article underscored the importance of a mul-tidisciplinary approach in managing POCD,involving the optimization of comor-bidities,depth of anesthesia monitoring,hemodynamic stability,and cerebral oxygenation monitoring.展开更多
Ribosomally synthesized and post-translationally modified peptides(RiPPs)constitute a vast and diverse family of bioactive peptides.These peptides,synthesized by ribosomes and subsequently modified by various tailorin...Ribosomally synthesized and post-translationally modified peptides(RiPPs)constitute a vast and diverse family of bioactive peptides.These peptides,synthesized by ribosomes and subsequently modified by various tailoring enzymes,possess a wide chemical space.Among these modifications,radical S-adenosylmethionine(rSAM)enzymes employ unique radical chemistry to introduce a variety of novel peptide structures,which are crucial for their activity.This review examines the major types of modifications in RiPPs catalyzed by rSAM enzymes,incorporating recent advancements in protein structure analysis techniques and computational methods.Additionally,it elucidates the diverse catalytic mechanisms and substrate selectivity of these enzymes through an analysis of the latest crystal structures.展开更多
Lithium-sulfur batteries(LSBs)have attracted significant attention due to their high theoretical energy density and low-cost raw materials.However,LSBs still face various challenges in practical applications,particula...Lithium-sulfur batteries(LSBs)have attracted significant attention due to their high theoretical energy density and low-cost raw materials.However,LSBs still face various challenges in practical applications,particularly the shuttle effect,electrode passivation,and slow kinetics.In recent years,trisulfur radicals(TRs),important intermediates in LSBs,have emerged as a promising and beyond-traditional solution to these problems,which serves as a mediated catalyst to improve the electrochemical performance of LSBs.As a system that is inconsistent with the catalytic conversion process discussed in the traditional LSBs,this review focuses on the generation,detection,promotion,and catalytic roles of TRs,especially emphasizing the formation of TRs in solid-state lapis lazuli analogs and discussing the pros and cons of high donor number solvents and/or their co-solvents in stabilizing TRs.Strategies involving homogeneous/heterogeneous catalysts are discussed for increment of TRs and enhancing catalytic reactions in LSBs.Ultimately,given TRs’significant potential as a key factor in enhancing the performance of LSBs,future perspectives and outlooks are provided to guide the further development of TRs in LSBs.This review provides valuable insights into the design of electrolytes and catalysts for increment of TRs,paving the new practical direction and way for advanced LSBs.展开更多
A photocatalyst-free photoinduced radical difluoromethylation approach for the convenient synthesis of 3-CF_(2)H-coumarins from alkynoates by difluoromethyl phenoxathiinium salt(PT-CF_(2)H^(+)BF_(4)^(-))was developed....A photocatalyst-free photoinduced radical difluoromethylation approach for the convenient synthesis of 3-CF_(2)H-coumarins from alkynoates by difluoromethyl phenoxathiinium salt(PT-CF_(2)H^(+)BF_(4)^(-))was developed.This transformation in-volves radical difluoromethylation/5-exo spirocyclization/ester migration rearrangement cascade process and features mild reaction conditions,broad substrate scope and good functional groups tolerance.Using this method,a wide range of alkynoates was successfully converted to desired 3-CF_(2)H-coumarins in moderate to good yields.展开更多
A new cobalt(Ⅱ)-radical complex:[Co(im4-py)_(2)(PNB)_(2)](im4-py=2-(4'-pyridyl)-4,4,5,5-tetramethylimidazole-1-oxyl,HPNB=p-nitrobenzoic acid)has been synthesized and characterized by X-ray diffraction analysis,el...A new cobalt(Ⅱ)-radical complex:[Co(im4-py)_(2)(PNB)_(2)](im4-py=2-(4'-pyridyl)-4,4,5,5-tetramethylimidazole-1-oxyl,HPNB=p-nitrobenzoic acid)has been synthesized and characterized by X-ray diffraction analysis,elemental analysis,IR,and magnetic properties.X-ray diffraction analysis shows that the complex exists as mononuclear molecules and Co(Ⅱ)ion is four-coordinated with two radicals and two PNB-ligands.The magnetic susceptibility study indicates the complex exhibits weak ferromagnetic interactions between cobalt(Ⅱ)and im4-py radical.The magnetic property is explained by the magnetic and structure exchange mechanism.CCDC:976028.展开更多
Objective:To evaluate the efficacy and user satisfaction of the MAIA^(TM)telemedicine platform for postoperative telemonitoring and telerehabilitation in patients undergoing robot-assisted radical prostatectomy(RARP)....Objective:To evaluate the efficacy and user satisfaction of the MAIA^(TM)telemedicine platform for postoperative telemonitoring and telerehabilitation in patients undergoing robot-assisted radical prostatectomy(RARP).Methods:Patients undergoing RARP(from April 2022 to January 2023)were divided into Group A,following the standard rehabilitation protocol,and Group B using the MAIA^(TM)platform for the first 30-day post-intervention period.Perioperative,pathological,and functional variables(continence and potency rates,assessed via validated questionnaires)were collected and telerehabilitation protocol’s adherence was monitored.The telerehabilitation system included an online platform for medical providers and a patient application,facilitating data acquisition,management,treatment planning,and monitoring.Patient and provider satisfactionwere evaluated using the visual analogue scale score and validated telemedicine satisfaction questionnaire.Results:Totally,227 patients were enrolled.No differences in perioperative or pathological variables were found.Group B had higher potency recovery rates than Group A(p=0.031);the potency recovery rates at 1 month and 3 months for Group B were 45%and 57%,respectively,and in Group A were 34%and 48%,respectively.At the multivariate analysis,MAIA^(TM)use and the nerve-sparing(NS)were independent predictors of erectile function at both 1 month(MAIA^(TM)use:odd ratio[OR]2.03,95%confidence interval[CI]1.13-3.63,p=0.018;NS:OR 2.08,95%CI 1.06-4.12,p=0.034)and 3 months(MAIA^(TM)use:OR 1.89,95%CI 1.07-3.34,p=0.028;NS:OR 1.90;95%CI 1.02-3.54,p=0.044).Adherencemonitoring revealed 4.6%of patients in Group B reported exercise issues due to pelvic pain onset and 10%did not take oral phosphodiesterase 5-inhibitors due to myalgia.All those patients restarted the rehabilitation program after televisit to address the causing problem,allowing restarting of a rehabilitation program.Patients reported high satisfaction with the MAIA^(TM)platform use(mean visual analogue scale score:88.7).Conclusion:The MAIA^(TM)telemedicine platform seems to have a role in optimizing early potency recovery after RARP.Patient and provider satisfaction levels were high,emphasizing the user-friendliness of the platform.展开更多
The performance of hydrogel radical polymerization under ambient conditions is a major challenge because oxygen is an effective radical quencher and the steps to remove or neutralize it are time consuming and laboriou...The performance of hydrogel radical polymerization under ambient conditions is a major challenge because oxygen is an effective radical quencher and the steps to remove or neutralize it are time consuming and laborious.A self-initiating system consisting of transition metals and acetylacetone has been successfully developed.The system is capable of initiating free radical polymerization of hydrogels at room temperature under aerobic conditions,which is attributed to carbon radicals generated by the oxidation of acetylacetone.Some of these carbon radicals reduce oxygen to generate hydroxyl radicals,which together induce self-coagulation of hydrogels.The polymerization system was effective for a variety of monomer and hydrogel swelling and shrinking schemes,and the reaction remained successful when exposed to saturated oxygen.In conclusion,the results demonstrate that the present strategy is an effective approach to addressing the challenge of deoxygenation in polymer synthesis,and provides a convenient method for synthesizing multifunctional hydrogels under ambient conditions.展开更多
BACKGROUND Patients with gastric cancer may have a risk of depression after radical surgery,which affects recovery and requires intensive intervention.AIM To explore the role of Bifidobacterium triple viable bacteria-...BACKGROUND Patients with gastric cancer may have a risk of depression after radical surgery,which affects recovery and requires intensive intervention.AIM To explore the role of Bifidobacterium triple viable bacteria-assisted mirtazapine in patients with depression after radical surgery for gastric cancer.METHODS This study included 80 patients with gastric cancer who experienced depression after undergoing radical surgery from January 2022 to December 2023 at Jiangnan University Hospital in Wuxi city in Jiangsu province.The patients were categorized into the control group(n=40)treated with mirtazapine and observation group(n=40)treated with combined Bifidobacterium triple viable bacteria-assisted mirtazapine.Neuroendocrine index,intestinal flora level,nutrition status,and patient quality of life were analyzed.RESULTS Before drug index level,no statistically significant difference was observed between the two groups (P>0.05).After drug administration,both groups experienced a decline in depression scores,cortisol,Escherichia coli,Enterococcus faecalis levels,and quality of life scores,whereas dopamine,serotonin,Lactobacillus,Bifidobacteria,hemoglobin,serum albumin and prealbumin levels increased.The observation group demonstrated significantly greater improvements across these indicators,with significant differences within groups and between groups(P<0.05).CONCLUSION Bifidobacterium has a relieving effect on depression in patients after radical surgery for gastric cancer,improves neuroendocrine status,regulates intestinal flora,and improves nutritional status and quality of life.展开更多
基金Financial support from the Fundamental Research Funds for Gannan Medical University(No.QD202429)National Natural Science Foundation of China(No.22171206)+2 种基金Natural Science Foundation of Zhejiang Province(No.LZ23B020001)Zhejiang Provincial Ten Thousand Talent Program(No.2023R5244)Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2020ZD04)is gratefully acknowledged.
文摘The Smiles rearrangement is an exceptionally versatile method in organic synthesis,providing a broad canvas for designing cascade reactions that construct new Csp^(2)-Y(Y=C,O,N,S,CO,etc.)bonds.Among the various types of Smiles rearrangement,the radical-type variant has emerged as a more powerful,mild,efficient,and modern synthetic technique compared to its traditional ionic counterpart.This approach excels in generating new(hetero)aromatic migration products,enabling significant advancements in recent years.This tutorial review focuses on the recent progress,since 2016,in the development and application of radical Smiles rearrangement in organic chemistry.Special attention is paid to novel transformations achieved through photochemical,electrochemical,and transition metal catalysis methods.
文摘Background:The Da Vinci Single-Port Robotic System(Da Vinci-SP),introduced by Intuitive(CA,USA)in 2018 in the USA and in 2024 in Europe,integrates advanced features like a flexible camera and articulating instruments.It has garnered significant interest in urology.Our report presents the first described European series of Radical Prostatectomies using the Da Vinci SP at the leading Italian center,Istituto Nazionale Tumori di Napoli,IRCCS“G.Pascale”Foundation,detailing the technical differences and challenges faced by experienced multiport robotic surgeons.Methods:Sixteen patients have been enrolled and underwent Single-Port(SP)Robot-Assisted Radical Prostatectomy(SP-RARP).Baseline characteristics of the patients were collected.We provided a step-by-step description of the surgical technique.Oncological outcomes have been evaluated and compared with magnetic resonance imaging(MRI)and biopsy results.Intraoperative,perioperative,and postoperative complications,surgical outcomes,functional outcomes,and technical issues of the new system were also documented.Results:All surgeries were successfully performed without the need for conversion.An extraperitoneal approach was used for all patients.Median Console time was 110 min.No complications were reported.The estimated median blood loss was 175 cc.Discharge from the hospital was on the first post-operative day for all patients.Bladder catheter removal was on day 7 without the need for cystography.Conclusions:We presented the first European case series of SP-RARP,reporting our experience and confirming the procedure’s feasibility for a highly experienced robotic surgeon.Experience with an extraperitoneal approach using the multiport(MP)platform,combined with well-conducted training for the SP system,may facilitate the transition to SP surgery.Further procedures and studies are needed to evaluate the oncological and functional outcomes.
基金supported by the Shaanxi Provincial Natural Science Basic Research Plan(2025JC-YBMS-114)the National Key Research and Development Program of China(2024YFB3212500)+1 种基金the Xi’an Jiaotong University(7121192002)the Fundamental Research Funds for the Central Universities(xzy022024023)。
文摘The radical addition/functional group migration strategy has emerged as a powerful tool for the difunctionalization of unsaturated hydrocarbons,yet the heteroatom-mediated functional group migration remains largely unexplored.Herein,we report an unprecedented radical difunctionalization of alkynes employing oxime esters as bifunctional reagents through a novel C-centered radical addition/N-centered radical translocation sequence.This innovative transformation paradigm enables efficient alkylamination of alkynes under mild photocatalytic redox conditions.Mechanistic investigations reveal a cascade sequence initiated by single-electron transfer from oxime derivatives,proceeding through radical addition,6-exo-trig cyclization,and subsequent imino group migration.
基金support from the Australian Research Council(ARC)Linkage Project(No.LP230100166).
文摘Selective depression of pyrite remains a major bottleneck in copper flotation,particularly when high-pyrite ores are processed and saline water is used.In such environments,conventional approaches using lime and inert grinding media often fail to discriminate ef-fectively between pyrite and valuable copper minerals due to strong copper activation on pyrite surfaces.This study introduced a novel approach using inorganic radicals generated from peroxymonosulfate(PMS)to selectively oxidize and depress pyrite.Flotation tests with synthetic high-pyrite ore blends showed that PMS significantly reduced pyrite recovery while maintaining or improving chalcopyrite flot-ation.Ethylenediaminetetraacetic acid(EDTA)extraction confirmed selective oxidation of pyrite,and electron paramagnetic resonance(EPR)spectroscopy identified hydroxyl(·OH)and sulfate(SO_(4)^(·-))radicals as the dominant reactive species.Iron ions from grinding me-dia and mineral surfaces were identified as key activators of PMS.A major insight was pyrite’s dual role,acting both as a radical scav-enger and an activator,which made it highly reactive and susceptible to radical-induced oxidation.This process converted surface copper-sulfur species into copper hydroxides,effectively suppressing pyrite flotation.While previous studies have applied EPR to detect radicals in simplified activator/precursor systems,this study provides the first direct mechanistic evidence of radical-driven selectivity in flotation by detecting inorganic radicals in a complex flotation slurry,thereby demonstrating their persistence under industrially relevant conditions and establishing a foundation for more effective and targeted flotation strategies.
基金The financial support from the National Natural Science Foundation of China (Nos.22150410339,W2432012,22301237 and 22171218)the Ministry of Science and Technology China (No.wgxz2022188) is greatly acknowledged。
文摘Radical cycloaddition reactions(RCRs) are highly effective methods for constructing complex carbo-and heterocycles,which are frequently encountered in natural products that exhibit intriguing biological properties and hold significant potential for applications in medicinal chemistry.Radical-mediated cycloaddition strategies,which recycle radical character,are particularly appealing because they require only a catalytic amount of reagent and promise reactions with theoretically high atom economy.This review focuses on recent developments and synthetic applications in RCRs,with an emphasis on visible lightinduced radical photocycloaddition reactions(RPCRs),transition metal-catalyzed approaches,and small molecule-catalyzed methods.By highlighting some outstanding innovations and addressing current challenges,this review aims to identify potential areas for improvement.These advancements will provide more efficient pathways for the synthesis of natural product molecules and offer valuable insights for the development of new synthetic methodologies.
文摘Objective:To analyze the impact of nursing interventions based on quantitative assessment using the Kano model on the quality of rehabilitation in patients with early-stage ovarian cancer following laparoscopic radical surgery.Methods:A prospective clinical study was conducted involving 96 patients with newly diagnosed early-stage ovarian cancer who underwent laparoscopic radical surgery from December 2023 to December 2025.Patients were randomly assigned to groups using a random number table method before surgery.After surgery,the control group(n=48)received routine quantitative assessment nursing interventions,while the observation group(n=48)received nursing interventions based on quantitative assessment using the Kano model.Both groups received continuous nursing care until discharge.Differences between the groups were compared in terms of negative emotions,quality of life scores before and after postoperative intervention,postoperative recovery indicators,and nursing satisfaction evaluations on the day of discharge.Results:After intervention,the observation group had lower scores on the Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS),as well as shorter recovery times for gastrointestinal function and food intake,and a shorter hospital stay compared to the control group.Additionally,the observation group had higher scores on the Quality-of-Life Instrument for Cancer Patients-Ovarian Cancer(QLICP-OV)than the control group,with statistically significant differences(p<0.05).The overall satisfaction with nursing care in the observation group was also higher than that in the control group,with a statistically significant difference(p<0.05).Conclusion:Implementing quantitative evaluation nursing interventions based on the Kano model for patients with early-stage ovarian cancer after laparoscopic radical surgery can,by addressing their postoperative basic health,disease awareness,and other intervention content needs to a comprehensive degree,actively promote postoperative recovery and improve their mental health and quality of life.
基金supported by the National Key R&D Program of China(2022YFA1502902)the National Natural Science Foundation of China(22201209,22271218,22071182,21931007,22301235)+1 种基金the Shaanxi Province Young Talent Support Plan(2023SYJ28)the Start-Up Funding of Tianjin University and Xi’an Jiaotong University。
文摘Photosynthesis of hydrogen peroxide(H_(2)O_(2))via oxygen reduction reaction(ORR)and water oxidation reaction(WOR)pathways requires controlled formation of radical intermediates.However,achieving precise control over radical formation in metal-free catalysts remains challenging.Herein,we report a fluorinated COF(Kf-F-COF)featuring framework-bound carbonyl groups as intrinsic radical-generating sites for efficient dual-channel H_(2)O_(2)photosynthesis.This design enables the simultaneous activation of O_(2)and H_(2)O through radical-mediated hydrogen atom transfer processes.Mechanistic studies reveal that fluorination enhances the electron affinity of the carbonyl sites,facilitates diradical formation,and lowers the energy barriers of key reaction steps.As a result,Kf-F-COF achieves a high H_(2)O_(2)production rate of 6.42 mmol g^(-1)h^(-1)and long-term stability under natural sunlight and seawater conditions.This work presents a frameworkcentered radical strategy for dual-pathway H_(2)O_(2)photosynthesis and offers mechanistic insights into regulating COF-based photocatalysts.
文摘Radical prostatectomy is a commonly used surgical method in cases of localized prostate cancer.In recent years,with the advent of new medical technologies and surgical techniques,the evolution of radical prostatectomy has revolutionized,especially in robot-assisted radical prostatectomy(RARP).The evolution of surgical approaches for radical prostatectomy has occurred in three stages:open surgery,laparoscopic intervention,and robot-assisted surgery.Regarding the functional recovery of patients who underwent laparoscopic radical prostatectomy or RARP,with the improvement of disease conditions,oncological prognosis of patients was not compromised.Particularly,RARP boasts distinguished novel techniques and approaches for maintaining urinary continence and sexual function in the short-and long-term.In addition,studies in the last two decades have shown its correlation with decreasing postoperative morbidity.In this paper,the available literatures related to the surgical approaches ranging from open surgery to RARP were reviewed,the superiority of any novel procedure was analyzed,and the advantages and disadvantages among the three modalities were compared,hoping to provide guidance to urologists when considering surgical approaches in the treatment of localized prostate cancer.
基金financially supported by the Jiangsu Province Shuangchuang Ph.D.award(No.JSSCBS20211267,Pei Xu)the Natural Science Research Project of Jiangsu Universities(No.23KJB150037,Pei Xu)+2 种基金sponsored by the Jiangsu Specially-Appointed Professor Program(Xu Zhu)the Start-up Funding provided by Xuzhou Medical UniversityThe Public Experimental Research Center of Xuzhou Medical University is also acknowledged。
文摘Oxalic acid salts(oxalate)were recently developed as C1 synthon,potent single-electron-transfer(SET)reductant,and hole scavengers via generation of CO_(2) and CO_(2) radical anion(CO_(2)·^(-))under mild photochemical conditions.A series of challenging reductive transformations were realized with oxalic dianion under catalytic photoredox conditions or through an electron-donor-acceptor(EDA)complex formation process.As a chemical intermediate for carbon capture and utilization(also a cheap and readily available reagent),oxalate salts could release one electron easily(E_(ox)=+0.06 V vs.SCE)via visible-light irradiation to give CO_(2) and CO_(2)·^(-) and therefore opened a new arena for reductive carboxylation reactions with highly expanded reaction diversity and chemical space to realize challenging C-X bond activation,alkenes cross coupling,and reductive carboxylation of unsaturated chemical bonds in a more sustainable and efficient way.This review features the recently developed aspects with oxalate salts and also an outlook for its further application in organic radical transformations.
文摘Objective:Radical prostatectomy(RP)is considered the gold standard treatment for patients with localized prostate cancer(PCa).All patients undergoing RP,either open,laparoscopic,or robotic,are at risk of developing urinary incontinence after RP.Our study aimed to analyze possible predictors of early postoperative(within 3 months)urinary continence(UC)outcomes following extraperitoneal single-site robot-assisted RP(ss-RARP)for localized PCa.Methods:We retrospectively reviewed data from 113 patients with localized PCa who were operated on by a highly experienced surgeon between September 2022 and December 2023.Patient characteristics(age,body mass index,prostate volume,prostate dimensions,preoperative and postoperative membranous urethral length,and percentage of membranous urethra removed)were analyzed using logistic regression to determine the independent factors contributing to short-term UC recovery after extraperitoneal ss-RARP.From the time of urinary catheter removal after surgery,the recovery of UC was followed up every month,and UC was defined as using≤1 safety pad daily,known as social continence.Results:The proportions of continent patients immediately after urinary catheter removal,1 month,and 3 months after extraperitoneal ss-RARP were 22%,49%,and 82%,respectively.The multivariate logistic regression analysis showed that the percentage of membranous urethra removed(p=0.016)and prostate volume(p=0.049)were associated with social UC recovery immediately after urinary catheter removal,and craniocaudal dimension of the prostate(p=0.042)and age(p=0.014)were associated with social UC recovery 1 month and 3 months after extraperitoneal ss-RARP,respectively.Conclusion:The percentage of membranous urethra removed,prostate volume,craniocaudal dimension of the prostate,and age are independent risk factors for social UC early after extraperitoneal ss-RARP.
基金Supported by the Science and Engineering Research Board(SERB),India(MTR/2020/000534).
文摘The significant role of square root mapping in probability,statistics,physics,architecture and engineering motivates us to emphasize on a new radical functional equation arising from a square root and reciprocal square root mappings.The interesting attribute of this equation is that it has both a square root mapping and a reciprocal square root mapping as solutions.We establish that the hyperstabilities of this equation exist using a fixed point alternative theorem.It is also demonstrated with an example that the stability may fail in special cases.
基金supported by the National Natural Science Foundation of China(Nos.52170156,52250056,and 52293443)the Shenzhen Science and Technology Program(No.KQTD20190929172630447).
文摘Harnessing bacteria for superoxide production in bioremediation holds immense promise,yet its practical application is hindered by slow production rates and the relatively weak redox potential of superoxide.This study delves into a cost-effective approach to amplify superoxide production using an Arthrobacter strain,a prevalent soil bacterial genus.Our research reveals that introducing a carbon source along with specific iron-binding ligands,including deferoxamine(DFO),diethylenetriamine pentaacetate(DTPA),citrate,and oxalate,robustly augments microbial superoxide generation.Moreover,our findings suggest that these iron-binding ligands play a pivotal role in converting superoxide into hydroxyl radicals by modulating the electron transfer rate between Fe(Ⅲ)/Fe(Ⅱ)and superoxide.Remarkably,among the tested ligands,only DTPA emerges as a potent promoter of this conversion process when complexed with Fe(Ⅲ).We identify an optimal Fe(Ⅲ)to DTPA ratio of approximately 1:1 for enhancing hydroxyl radical production within the Arthrobacter culture.This research underscores the efficacy of simultaneously introducing carbon sources and DTPA in facilitating superoxide production and its subsequent conversion to hydroxyl radicals,significantly elevating bioremediation performance.Furthermore,our study reveals that DTPA augments superoxide production in cultures of diverse soils,with various soil microorganisms beyond Arthrobacter identified as contributors to superoxide generation.This emphasizes the universal applicability of DTPA across multiple bacterial genera.In conclusion,our study introduces a promising methodology for enhancing microbial superoxide production and its conversion into hydroxyl radicals.These findings hold substantial implications for the deployment of microbial reactive oxygen species in bioremediation,offering innovative solutions for addressing environmental contamination challenges.
文摘This article explored the application of dexmedetomidine(Dex),a highly selective alpha-2 agonist,in managing postoperative cognitive dysfunction(POCD)in elderly patients undergoing radical colon cancer surgery.Aging is associated with a progressive decline in physiological functions and an increased risk of adverse surgical outcomes,including POCD,which encompasses many neurocognitive disorders that manifest during the perioperative period.The aging population is at a higher risk for POCD,which can lead to prolonged hospital stays,delayed recovery,and increased healthcare costs.Dex has neuroprotective,opioid-sparing,and sympatholytic properties,which reduces the incidence and severity of POCD.Dex was introduced for sedation in patients receiving mechanical ventilation but has since been adopted in anesthesia due to its multifaceted benefits.Its appli-cation extends to sedation,analgesia,maintenance of anesthesia,and controlling delirium.Its neuroprotective and anti-inflammatory effects have been explored in managing POCD.This article discussed the broad range of patient and procedure-related risk factors for POCD.Early identification and intervention are crucial to prevent the progression of POCD,which can have severe physical,psychological,and economic consequences.The article underscored the importance of a mul-tidisciplinary approach in managing POCD,involving the optimization of comor-bidities,depth of anesthesia monitoring,hemodynamic stability,and cerebral oxygenation monitoring.
基金supported by the National Key Research and Development Program of China(No.2023YFA0916000)the National Natural Science Foundation of China(No.32371324)the High-level Talent Startup Fund provided by China Pharmaceutical University.
文摘Ribosomally synthesized and post-translationally modified peptides(RiPPs)constitute a vast and diverse family of bioactive peptides.These peptides,synthesized by ribosomes and subsequently modified by various tailoring enzymes,possess a wide chemical space.Among these modifications,radical S-adenosylmethionine(rSAM)enzymes employ unique radical chemistry to introduce a variety of novel peptide structures,which are crucial for their activity.This review examines the major types of modifications in RiPPs catalyzed by rSAM enzymes,incorporating recent advancements in protein structure analysis techniques and computational methods.Additionally,it elucidates the diverse catalytic mechanisms and substrate selectivity of these enzymes through an analysis of the latest crystal structures.
基金supported by the National Key Research and Development Program of China(No.2021YFF0500600)National Natural Science Foundation of China(No.22309165),Natural Science Foundation of Henan Province(No.232300420296)Key Scientific Research Project Plan of Henan Provincial Higher Education Institutions(No.25B430006).
文摘Lithium-sulfur batteries(LSBs)have attracted significant attention due to their high theoretical energy density and low-cost raw materials.However,LSBs still face various challenges in practical applications,particularly the shuttle effect,electrode passivation,and slow kinetics.In recent years,trisulfur radicals(TRs),important intermediates in LSBs,have emerged as a promising and beyond-traditional solution to these problems,which serves as a mediated catalyst to improve the electrochemical performance of LSBs.As a system that is inconsistent with the catalytic conversion process discussed in the traditional LSBs,this review focuses on the generation,detection,promotion,and catalytic roles of TRs,especially emphasizing the formation of TRs in solid-state lapis lazuli analogs and discussing the pros and cons of high donor number solvents and/or their co-solvents in stabilizing TRs.Strategies involving homogeneous/heterogeneous catalysts are discussed for increment of TRs and enhancing catalytic reactions in LSBs.Ultimately,given TRs’significant potential as a key factor in enhancing the performance of LSBs,future perspectives and outlooks are provided to guide the further development of TRs in LSBs.This review provides valuable insights into the design of electrolytes and catalysts for increment of TRs,paving the new practical direction and way for advanced LSBs.
文摘A photocatalyst-free photoinduced radical difluoromethylation approach for the convenient synthesis of 3-CF_(2)H-coumarins from alkynoates by difluoromethyl phenoxathiinium salt(PT-CF_(2)H^(+)BF_(4)^(-))was developed.This transformation in-volves radical difluoromethylation/5-exo spirocyclization/ester migration rearrangement cascade process and features mild reaction conditions,broad substrate scope and good functional groups tolerance.Using this method,a wide range of alkynoates was successfully converted to desired 3-CF_(2)H-coumarins in moderate to good yields.
文摘A new cobalt(Ⅱ)-radical complex:[Co(im4-py)_(2)(PNB)_(2)](im4-py=2-(4'-pyridyl)-4,4,5,5-tetramethylimidazole-1-oxyl,HPNB=p-nitrobenzoic acid)has been synthesized and characterized by X-ray diffraction analysis,elemental analysis,IR,and magnetic properties.X-ray diffraction analysis shows that the complex exists as mononuclear molecules and Co(Ⅱ)ion is four-coordinated with two radicals and two PNB-ligands.The magnetic susceptibility study indicates the complex exhibits weak ferromagnetic interactions between cobalt(Ⅱ)and im4-py radical.The magnetic property is explained by the magnetic and structure exchange mechanism.CCDC:976028.
文摘Objective:To evaluate the efficacy and user satisfaction of the MAIA^(TM)telemedicine platform for postoperative telemonitoring and telerehabilitation in patients undergoing robot-assisted radical prostatectomy(RARP).Methods:Patients undergoing RARP(from April 2022 to January 2023)were divided into Group A,following the standard rehabilitation protocol,and Group B using the MAIA^(TM)platform for the first 30-day post-intervention period.Perioperative,pathological,and functional variables(continence and potency rates,assessed via validated questionnaires)were collected and telerehabilitation protocol’s adherence was monitored.The telerehabilitation system included an online platform for medical providers and a patient application,facilitating data acquisition,management,treatment planning,and monitoring.Patient and provider satisfactionwere evaluated using the visual analogue scale score and validated telemedicine satisfaction questionnaire.Results:Totally,227 patients were enrolled.No differences in perioperative or pathological variables were found.Group B had higher potency recovery rates than Group A(p=0.031);the potency recovery rates at 1 month and 3 months for Group B were 45%and 57%,respectively,and in Group A were 34%and 48%,respectively.At the multivariate analysis,MAIA^(TM)use and the nerve-sparing(NS)were independent predictors of erectile function at both 1 month(MAIA^(TM)use:odd ratio[OR]2.03,95%confidence interval[CI]1.13-3.63,p=0.018;NS:OR 2.08,95%CI 1.06-4.12,p=0.034)and 3 months(MAIA^(TM)use:OR 1.89,95%CI 1.07-3.34,p=0.028;NS:OR 1.90;95%CI 1.02-3.54,p=0.044).Adherencemonitoring revealed 4.6%of patients in Group B reported exercise issues due to pelvic pain onset and 10%did not take oral phosphodiesterase 5-inhibitors due to myalgia.All those patients restarted the rehabilitation program after televisit to address the causing problem,allowing restarting of a rehabilitation program.Patients reported high satisfaction with the MAIA^(TM)platform use(mean visual analogue scale score:88.7).Conclusion:The MAIA^(TM)telemedicine platform seems to have a role in optimizing early potency recovery after RARP.Patient and provider satisfaction levels were high,emphasizing the user-friendliness of the platform.
基金funded by the National Key R&D Program of China(No.2022YFF0904000)Cross-disciplinary Innovation Project of Jilin University(No.JLUXKJC2021ZZ01)the financial support from National Natural Science Foundation of China(No.62201497).
文摘The performance of hydrogel radical polymerization under ambient conditions is a major challenge because oxygen is an effective radical quencher and the steps to remove or neutralize it are time consuming and laborious.A self-initiating system consisting of transition metals and acetylacetone has been successfully developed.The system is capable of initiating free radical polymerization of hydrogels at room temperature under aerobic conditions,which is attributed to carbon radicals generated by the oxidation of acetylacetone.Some of these carbon radicals reduce oxygen to generate hydroxyl radicals,which together induce self-coagulation of hydrogels.The polymerization system was effective for a variety of monomer and hydrogel swelling and shrinking schemes,and the reaction remained successful when exposed to saturated oxygen.In conclusion,the results demonstrate that the present strategy is an effective approach to addressing the challenge of deoxygenation in polymer synthesis,and provides a convenient method for synthesizing multifunctional hydrogels under ambient conditions.
文摘BACKGROUND Patients with gastric cancer may have a risk of depression after radical surgery,which affects recovery and requires intensive intervention.AIM To explore the role of Bifidobacterium triple viable bacteria-assisted mirtazapine in patients with depression after radical surgery for gastric cancer.METHODS This study included 80 patients with gastric cancer who experienced depression after undergoing radical surgery from January 2022 to December 2023 at Jiangnan University Hospital in Wuxi city in Jiangsu province.The patients were categorized into the control group(n=40)treated with mirtazapine and observation group(n=40)treated with combined Bifidobacterium triple viable bacteria-assisted mirtazapine.Neuroendocrine index,intestinal flora level,nutrition status,and patient quality of life were analyzed.RESULTS Before drug index level,no statistically significant difference was observed between the two groups (P>0.05).After drug administration,both groups experienced a decline in depression scores,cortisol,Escherichia coli,Enterococcus faecalis levels,and quality of life scores,whereas dopamine,serotonin,Lactobacillus,Bifidobacteria,hemoglobin,serum albumin and prealbumin levels increased.The observation group demonstrated significantly greater improvements across these indicators,with significant differences within groups and between groups(P<0.05).CONCLUSION Bifidobacterium has a relieving effect on depression in patients after radical surgery for gastric cancer,improves neuroendocrine status,regulates intestinal flora,and improves nutritional status and quality of life.
