The current financial education framework has an increasing need to introduce tools that facilitate the application of theoretical models to real-world data and contexts.However,only a limited number of free tools are...The current financial education framework has an increasing need to introduce tools that facilitate the application of theoretical models to real-world data and contexts.However,only a limited number of free tools are available for this purpose.Given this lack of tools,the present study provides two approaches to facilitate the implementa-tion of an event study.The first approach consists of a set of MS Excel files based on the Fama–French five-factor model,which allows the application of the event study methodology in a semi-automatic manner.The second approach is an open-source R-programmed tool through which results can be obtained in the context of an event study without the need for programming knowledge.This tool widens the calculus possibilities provided by the first approach and offers the option to apply not only the Fama–French five-factor model but also other models that are common in the finan-cial literature.It is a user-friendly tool that enables reproducibility of the analysis and ensures that the calculations are free of manipulation errors.Both approaches are freely available and ready-to-use.展开更多
Genotype x environmental interaction (GxE) can lead to differences in performance of genotypes over environments. GxE analysis can be used to analyze the stability of genotypes and the value of test locations. We deve...Genotype x environmental interaction (GxE) can lead to differences in performance of genotypes over environments. GxE analysis can be used to analyze the stability of genotypes and the value of test locations. We developed an Rlanguage program (RGxE) that computes univariate stability statistics, descriptive statistics, pooled ANOVA, genotype F ratio across location and environment, cluster analysis for location, and location correlation with average location performance. Univariate stability statistics calculated are regression slope (bi), deviation from regression (S2d), Shukla’s variance (σi2), S square Wricke’s ecovalence (Wi), and Kang’s yield stability (YSi). RGxE is free and intended for use by scientists studying performance of polygenic or quantitative traits over multiple environments. In the present paper we provide the RGxE program and its components along with an example input data and outputs. Additionally, the RGxE program along with associated files is also available on GitHub at https://github.com/mahendra1/RGxE, http://cucurbitbreeding.com/todd-wehner/publications/software-sas-r-project/? and http://cuke.hort.ncsu.edu/cucurbit/wehner/software.html.展开更多
In the Acknowledgements section of this article,the grant number"2020YFE0205900"relating to"National Key R&D Program of China"was missing,it has been included and the corrected Acknowledgements...In the Acknowledgements section of this article,the grant number"2020YFE0205900"relating to"National Key R&D Program of China"was missing,it has been included and the corrected Acknowledgements section is given below.展开更多
Good laboratory practice（GLP） plays an important role in pre-clinical studies, which are a key stage in new drug research and development（R＆D）. The development of GLP in China started in the late 1990 s. Followin...Good laboratory practice（GLP） plays an important role in pre-clinical studies, which are a key stage in new drug research and development（R＆D）. The development of GLP in China started in the late 1990 s. Following 20 years of developments, GLP system has already been established in this country. This review firstly evaluated all the institutions in this field, and described the annual number and total number of institutions, the distribution of GLP institutions, the types of GLP institutions, and the service provided by these GLP institutions. Since the initiation of the National Key Technology R＆D Program during the 11 th Five-Year Plan, it had a significant effect on the development of GLP. Therefore, the institutions which have undertaken projects from this program will be introduced later. We also described the infrastructure of hardware and software in GLP institutions along with their faults, such as variation in development and the lack of innovation.展开更多
作为一种广为接受的语义数据模型,E-R模型被广泛地应用于数据库设计阶段.但是E-R模型自身却存在某些缺陷,这些缺陷制约了对其进一步的应用.针对E-R模型的改进,目前主要存在基于图形表示和描述性逻辑表示两种途径.但是,前者仍然不具有自...作为一种广为接受的语义数据模型,E-R模型被广泛地应用于数据库设计阶段.但是E-R模型自身却存在某些缺陷,这些缺陷制约了对其进一步的应用.针对E-R模型的改进,目前主要存在基于图形表示和描述性逻辑表示两种途径.但是,前者仍然不具有自动推理能力,而后者却存在表示能力弱、与数据库兼容性不足等缺陷.为克服以上缺陷,提出一种利用回答集编程(answer set programming)表示E-R模型的新方法.首先,对应于数据库的E-R模式被区分为基本和扩展两种类型,并分别完成它们的语法与语义定义.其次,利用回答集编程完成以上两类模式的逻辑编程表示.最后,完成表示的正确性证明.提出的方法不仅为E-R模型提供了一种新的逻辑表示途径,而且相对原有的两种E-R模型改进途径具有明显的优势.更为重要的是该研究成果使得应用E-R模型实现异构数据库之间的语义协作成为可能.展开更多
基金the Secretaria d’Universitats i Recerca del Departament d’Empresa i Coneixement of the Catalan government,and to Universitat Ramon Llull for their financial support.The financial support for this work did not influence its outcome.
文摘The current financial education framework has an increasing need to introduce tools that facilitate the application of theoretical models to real-world data and contexts.However,only a limited number of free tools are available for this purpose.Given this lack of tools,the present study provides two approaches to facilitate the implementa-tion of an event study.The first approach consists of a set of MS Excel files based on the Fama–French five-factor model,which allows the application of the event study methodology in a semi-automatic manner.The second approach is an open-source R-programmed tool through which results can be obtained in the context of an event study without the need for programming knowledge.This tool widens the calculus possibilities provided by the first approach and offers the option to apply not only the Fama–French five-factor model but also other models that are common in the finan-cial literature.It is a user-friendly tool that enables reproducibility of the analysis and ensures that the calculations are free of manipulation errors.Both approaches are freely available and ready-to-use.
文摘Genotype x environmental interaction (GxE) can lead to differences in performance of genotypes over environments. GxE analysis can be used to analyze the stability of genotypes and the value of test locations. We developed an Rlanguage program (RGxE) that computes univariate stability statistics, descriptive statistics, pooled ANOVA, genotype F ratio across location and environment, cluster analysis for location, and location correlation with average location performance. Univariate stability statistics calculated are regression slope (bi), deviation from regression (S2d), Shukla’s variance (σi2), S square Wricke’s ecovalence (Wi), and Kang’s yield stability (YSi). RGxE is free and intended for use by scientists studying performance of polygenic or quantitative traits over multiple environments. In the present paper we provide the RGxE program and its components along with an example input data and outputs. Additionally, the RGxE program along with associated files is also available on GitHub at https://github.com/mahendra1/RGxE, http://cucurbitbreeding.com/todd-wehner/publications/software-sas-r-project/? and http://cuke.hort.ncsu.edu/cucurbit/wehner/software.html.
文摘In the Acknowledgements section of this article,the grant number"2020YFE0205900"relating to"National Key R&D Program of China"was missing,it has been included and the corrected Acknowledgements section is given below.
基金National Special Project Funds(Grant No.2012ZX09302,2013ZX09302)
文摘Good laboratory practice（GLP） plays an important role in pre-clinical studies, which are a key stage in new drug research and development（R＆D）. The development of GLP in China started in the late 1990 s. Following 20 years of developments, GLP system has already been established in this country. This review firstly evaluated all the institutions in this field, and described the annual number and total number of institutions, the distribution of GLP institutions, the types of GLP institutions, and the service provided by these GLP institutions. Since the initiation of the National Key Technology R＆D Program during the 11 th Five-Year Plan, it had a significant effect on the development of GLP. Therefore, the institutions which have undertaken projects from this program will be introduced later. We also described the infrastructure of hardware and software in GLP institutions along with their faults, such as variation in development and the lack of innovation.
文摘作为一种广为接受的语义数据模型,E-R模型被广泛地应用于数据库设计阶段.但是E-R模型自身却存在某些缺陷,这些缺陷制约了对其进一步的应用.针对E-R模型的改进,目前主要存在基于图形表示和描述性逻辑表示两种途径.但是,前者仍然不具有自动推理能力,而后者却存在表示能力弱、与数据库兼容性不足等缺陷.为克服以上缺陷,提出一种利用回答集编程(answer set programming)表示E-R模型的新方法.首先,对应于数据库的E-R模式被区分为基本和扩展两种类型,并分别完成它们的语法与语义定义.其次,利用回答集编程完成以上两类模式的逻辑编程表示.最后,完成表示的正确性证明.提出的方法不仅为E-R模型提供了一种新的逻辑表示途径,而且相对原有的两种E-R模型改进途径具有明显的优势.更为重要的是该研究成果使得应用E-R模型实现异构数据库之间的语义协作成为可能.
