Objective To observe the effect of acupuncture at Quchi(LI11)on the serum interleukin-2(IL-2)level and the severity of uremic pruritus(UP)in hemodialysis patients.Methods Sixty hemodialysis patients with UP were rando...Objective To observe the effect of acupuncture at Quchi(LI11)on the serum interleukin-2(IL-2)level and the severity of uremic pruritus(UP)in hemodialysis patients.Methods Sixty hemodialysis patients with UP were randomized into an acupuncture group and a control group,with 30 cases in each group.In the acupuncture group,patients were treated with acupuncture at Quchi(LI11)twice a week for six weeks.In the control group,each patient received a placebo treatment(sham acupuncture).Before and after the intervention,the pruritis severity was examined using a 5-D scale,and the serum IL-2 level was measured using an enzyme-linked immunosorbent assay kit.Results There were no statistically significant differences in the demographic or clinical factors between the control group and the acupuncture group at baseline.The reduction in pruritus severity in patients was more significant in the acupuncture group(P=0.027).Acupuncture therapy also significantly decreased the serum IL-2 level in the patients(P=0.011).Throughout the acupuncture procedures,the incidence of pain and mild bleeding was 3.6%and 2.5%,respectively.Conclusion Six-week acupuncture treatment at Quchi(LI11)can effectively decrease the severity of UP and the serum IL-2 level.Large-scale,long-duration,and multi-center studies are needed to fully understand the role of IL-2 in inflammation and neuroimmune stimulation during acupuncture.展开更多
目的:基于多元数据挖掘,分析现代文献中曲池穴的常用疗法、主治优势病症及配伍规律。方法:检索中国知网(CNKI)、万方(Wangfang Data)、维普(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、Web of Science、Embase数据库中曲池的相关...目的:基于多元数据挖掘,分析现代文献中曲池穴的常用疗法、主治优势病症及配伍规律。方法:检索中国知网(CNKI)、万方(Wangfang Data)、维普(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、Web of Science、Embase数据库中曲池的相关文献,建立主治病症及配穴等数据库,采用多元数据挖掘进行可视化、关联规则及聚类分析。结果:共纳入1408篇文献,穴位注射、针刺、刺络放血、电针、艾灸、推拿为常用疗法;以出现频次降序排列为准,单穴优势病症7种,前5位是发热、眩晕、瘾疹、肱骨外上髁炎和腰痛;配伍优势病症25种,前5位是中风、痿证、痹证、眩晕和颈椎病。配穴以特定穴为主,归经前3位分别是手阳明大肠经、足阳明胃经、足太阴脾经,高频配穴涵盖合谷、足三里、三阴交、外关、血海等22个穴位,通过分析得到20个支持度较高的关联组合和6个有效聚类群。结论:曲池穴治疗范围广泛,以发热、中风、瘾疹为核心优势病症;配伍注重与特定穴联合,以曲池-足三里-合谷为核心组合。展开更多
Objective To compare therapeutic effects of electroacupuncture and western medicine on blood pressure variability in young patients with hypertension. Methods Sixty cases of young patients of hypertension were randoml...Objective To compare therapeutic effects of electroacupuncture and western medicine on blood pressure variability in young patients with hypertension. Methods Sixty cases of young patients of hypertension were randomly divided into an electroacupuncture group and a western medicine group, 30 cases in each group. In the electroacupuncture group, electroacupuncture was applied at Quchi （曲池LI 11） and Taichong （太冲LR 3）. In the western medicine group, Captopril was taken orally. Twenty-four hour dynamic blood pressure, and blood pressure variability and circadian rhythms were observed after treatment for 14 days in the two groups. Results Electroacupuncture at Quchi （曲池LI 11） and Taichong （太冲LR 3） significantly decreased systolic pressure and diastolic pressure at different time phases in the young patients with hypertension （all P〈0.01）, with no significant difference as compared with the western medicine group （all P〉0.05）; electroacupuncture at Quchi （曲池LI 11） and Taichong （太冲LR 3） significantly reduced the standard deviations of systolic pressure and diastolic pressure at different time phases in the young patients with hypertension as compared with those before the treatment （P〈0.01, P〈0.05）. There were statistically significant differences between the two groups in 24 h systolic standard deviation （24 h SSD）, 24 h diastolic standard deviation （24 h DSD）, daytime SSD （dSSD）, nighttime SSD （nSSD） and nighttime DSD （nDSD） （P〈0.01, P〈0.05）; and there was significant difference between the two groups in numbers of the Dipper and the non-Dipper after treatment （P〈0.05）. Conclusion Electroacupuncture at Quchi （曲池LI 11） and Taichong （太冲LR 3） has a better long-term effect of decreasing blood pressure and improves effectively changes of circadian rhythms in young patients with hypertension, which are an effective point pair for hypertension.展开更多
文摘Objective To observe the effect of acupuncture at Quchi(LI11)on the serum interleukin-2(IL-2)level and the severity of uremic pruritus(UP)in hemodialysis patients.Methods Sixty hemodialysis patients with UP were randomized into an acupuncture group and a control group,with 30 cases in each group.In the acupuncture group,patients were treated with acupuncture at Quchi(LI11)twice a week for six weeks.In the control group,each patient received a placebo treatment(sham acupuncture).Before and after the intervention,the pruritis severity was examined using a 5-D scale,and the serum IL-2 level was measured using an enzyme-linked immunosorbent assay kit.Results There were no statistically significant differences in the demographic or clinical factors between the control group and the acupuncture group at baseline.The reduction in pruritus severity in patients was more significant in the acupuncture group(P=0.027).Acupuncture therapy also significantly decreased the serum IL-2 level in the patients(P=0.011).Throughout the acupuncture procedures,the incidence of pain and mild bleeding was 3.6%and 2.5%,respectively.Conclusion Six-week acupuncture treatment at Quchi(LI11)can effectively decrease the severity of UP and the serum IL-2 level.Large-scale,long-duration,and multi-center studies are needed to fully understand the role of IL-2 in inflammation and neuroimmune stimulation during acupuncture.
文摘目的:基于多元数据挖掘,分析现代文献中曲池穴的常用疗法、主治优势病症及配伍规律。方法:检索中国知网(CNKI)、万方(Wangfang Data)、维普(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、Web of Science、Embase数据库中曲池的相关文献,建立主治病症及配穴等数据库,采用多元数据挖掘进行可视化、关联规则及聚类分析。结果:共纳入1408篇文献,穴位注射、针刺、刺络放血、电针、艾灸、推拿为常用疗法;以出现频次降序排列为准,单穴优势病症7种,前5位是发热、眩晕、瘾疹、肱骨外上髁炎和腰痛;配伍优势病症25种,前5位是中风、痿证、痹证、眩晕和颈椎病。配穴以特定穴为主,归经前3位分别是手阳明大肠经、足阳明胃经、足太阴脾经,高频配穴涵盖合谷、足三里、三阴交、外关、血海等22个穴位,通过分析得到20个支持度较高的关联组合和6个有效聚类群。结论:曲池穴治疗范围广泛,以发热、中风、瘾疹为核心优势病症;配伍注重与特定穴联合,以曲池-足三里-合谷为核心组合。
基金Supported by Project of Shandong Provincial 2005–2006 TCM Science and Technology Development Plan:2005-206
文摘Objective To compare therapeutic effects of electroacupuncture and western medicine on blood pressure variability in young patients with hypertension. Methods Sixty cases of young patients of hypertension were randomly divided into an electroacupuncture group and a western medicine group, 30 cases in each group. In the electroacupuncture group, electroacupuncture was applied at Quchi （曲池LI 11） and Taichong （太冲LR 3）. In the western medicine group, Captopril was taken orally. Twenty-four hour dynamic blood pressure, and blood pressure variability and circadian rhythms were observed after treatment for 14 days in the two groups. Results Electroacupuncture at Quchi （曲池LI 11） and Taichong （太冲LR 3） significantly decreased systolic pressure and diastolic pressure at different time phases in the young patients with hypertension （all P〈0.01）, with no significant difference as compared with the western medicine group （all P〉0.05）; electroacupuncture at Quchi （曲池LI 11） and Taichong （太冲LR 3） significantly reduced the standard deviations of systolic pressure and diastolic pressure at different time phases in the young patients with hypertension as compared with those before the treatment （P〈0.01, P〈0.05）. There were statistically significant differences between the two groups in 24 h systolic standard deviation （24 h SSD）, 24 h diastolic standard deviation （24 h DSD）, daytime SSD （dSSD）, nighttime SSD （nSSD） and nighttime DSD （nDSD） （P〈0.01, P〈0.05）; and there was significant difference between the two groups in numbers of the Dipper and the non-Dipper after treatment （P〈0.05）. Conclusion Electroacupuncture at Quchi （曲池LI 11） and Taichong （太冲LR 3） has a better long-term effect of decreasing blood pressure and improves effectively changes of circadian rhythms in young patients with hypertension, which are an effective point pair for hypertension.
