Detrital geochronology fundamentally involves the quantification of major age ranges and their weights winthin an age distribution.This study presents a streamlined approach,modeling the age distribution of detrital z...Detrital geochronology fundamentally involves the quantification of major age ranges and their weights winthin an age distribution.This study presents a streamlined approach,modeling the age distribution of detrital zircons using a normal mixture model,and employs the Expectation-Maximization(EM)algorithm for precise estimations.A method is introduced to automatically select appropriate initial mean values for EM algorithm,enhancing its efficacy in detrital geochronology.This process entails multiple trials with varying numbers of age components leading to diverse k-component models.The model with the lowest Bayesian Information Criterion(BIC)is identified as the most suitable.For accurate component number and weight determination,a substantial sample size(n>200)is advisable. Our findings based on both synthetic and empirical datasets confirm that the normal mixture model,refined by the EM algorithm,reliably identifies key age parameters with minimal error.As a kind of probability density estimator,the normal mixture model offers a novel visualization tool for detrital data and an alternative foundation for KDE in calculating existing similarity metrics.Another focus of this study is the critical examination of quantitative metrics for comparing detrital zircon age patterns.Through a case study,this study demonstrates that metrics based on empirical cumulative probability distribution(such as K-S and Kuiper statistics)may lead to erroneous conclusions.The employment of the Kullback-Leibler(KL)divergence,a metric grounded in probability density estimation,is proposed.Reference critical values,simulated via the Monte Carlo method,provide more objective benchmarks for these quantitative metrics. All methodologies discussed are encapsulated in a series of MATLAB scripts,available as open-source code and a standalone application,facilitating wider adoption and application in the field.展开更多
Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grad...Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grade and discriminating San-Huang Tablets (SHT) of different commercial brands. The systematic quantified fingerprint method (SQFM) was applied to evaluate, qualitatively and quantitatively, the quality consistency of the herbal preparation. It was possible to deduce that the quantitative similarity analysis by SQFM was enabled to make a good discrimination of the tested samples. It was a particularly useful method for the overall quality evaluation of herbal medicine and their preparations.展开更多
The hydrogen evolution reaction(HER)in electrochemical water splitting is crucial for green hydrogen production,yet its efficiency is limited by bubble dynamics at the electrode surface.Accumulated bubbles can block a...The hydrogen evolution reaction(HER)in electrochemical water splitting is crucial for green hydrogen production,yet its efficiency is limited by bubble dynamics at the electrode surface.Accumulated bubbles can block active sites,hinder mass transport,and increase local resistance,causing energy loss.Thus,precise bubble monitoring is crucial for understanding performance limitations and optimizing catalyst design.Conventional bubble monitoring techniques,such as optical microscopy,high-speed imaging,and electrochemical impedance,are constrained by real-time accuracy,complex post-processing,or signal interference at high current densities.Here,we present an in situ fiber optic sensing system that enables precise,real-time monitoring of bubble dynamics during HER.Unlike traditional methods,this system leverages the sensitivity and real-time capability of fiber optic sensors to quantify key parameters,such as growth rate,detachment rate,intake/output ratio,and detaching size.Its reliability and adaptability were validated using two different Pt/C-loaded carbon paper catalysts with distinct catalytic properties.Notably,the system also achieves a bubble detection limit of 79μm,which meets the spatial resolution requirements for monitoring bubble dynamics relevant to electrocatalytic activity in HER.This sensing platform establishes a practical framework for connecting interfacial gas evolution to electrochemical performance,offering valuable insight for optimizing HER efficiency through catalyst design.展开更多
BACKGROUND The impact of transjugular intrahepatic portosystemic shunt(TIPS)on liver and spleen stiffness remains unclear,as does the association between preoperative liver and spleen stiffness and prognosis following...BACKGROUND The impact of transjugular intrahepatic portosystemic shunt(TIPS)on liver and spleen stiffness remains unclear,as does the association between preoperative liver and spleen stiffness and prognosis following TIPS.AIM To investigate changes in liver and spleen stiffness after TIPS and examines the relationship between these parameters and the prognosis of post-TIPS patients.METHODS A total of 76 patients with liver cirrhosis and portal hypertension who underwent TIPS were included.Liver and spleen stiffness was assessed using the sound touch quantify(STQ)value,determined via point shear wave elastography in ultrasound imaging.Cox regression analysis was employed to evaluate the relationship between liver and spleen stiffness and cumulative survival in TIPS patients.RESULTS The liver STQ value demonstrated a marginally decreasing trend over time(P=0.052),while the spleen STQ value showed a significantly decreasing trend(P=0.025).Spleen STQ was positively correlated with portal pressure gradient(PPG)levels(rs=0.327,P=0.025).Cox regression analysis indicated that older age[hazard ratio(HR)=1.063,95%CI:0.997-1.133,P=0.060]and a higher liver STQ value(HR=1.051,95%CI:1.009-1.095,P=0.018)were associated with an increased mortality risk after TIPS.No significant correlation was found between liver or spleen stiffness and overt hepatic encephalopathy post-TIPS.The liver STQ value[area under the receiver operating characteristic curve(AUC)=0.724(95%CI:0.563-0.884)]showed superior predictive performance compared to the Child-Pugh score[AUC=0.699(95%CI:0.529-0.870)]and was comparable to the model for end-stage liver disease score[AUC=0.746(95%CI:0.591-0.902)].CONCLUSION Following TIPS,spleen stiffness exhibited a more pronounced change than liver stiffness and was positively associated with PPG.Preoperative liver stiffness serves as a prognostic indicator for survival in patients undergoing TIPS.展开更多
Efficient tool condition monitoring techniques help to realize intelligent management of tool life and reduce tool usage costs.In this paper,the influence of different wear degrees of ball-end milling cutters on the t...Efficient tool condition monitoring techniques help to realize intelligent management of tool life and reduce tool usage costs.In this paper,the influence of different wear degrees of ball-end milling cutters on the texture shape of machining tool marks is investigated,and a method is proposed for predicting the wear state(including the position and degree of tool wear)of ball-end milling cutters based on entropy measurement of tool mark texture images.Firstly,data samples are prepared through wear experiments,and the change law of the tool mark texture shape with the tool wear state is analyzed.Then,a two-dimensional sample entropy algorithm is developed to quantify the texture morphology.Finally,the processing parameters and tool attitude are integrated into the prediction process to predict the wear value and wear position of the ball end milling cutter.After testing,the correlation between the predicted value and the standard value of the proposed tool condition monitoring method reaches 95.32%,and the accuracy reaches 82.73%,indicating that the proposed method meets the requirement of tool condition monitoring.展开更多
Objective To assess left ventricular (LV) strain by3-dimensional speckle tracking imaging (3D-STI) in patients with coronary heart disease (CHD) .Methods All subjects underwent invasive coronary angiography.2-dimensio...Objective To assess left ventricular (LV) strain by3-dimensional speckle tracking imaging (3D-STI) in patients with coronary heart disease (CHD) .Methods All subjects underwent invasive coronary angiography.2-dimensional and 3-dimensional echocardiography were performed in 52 subjects with suspected CHD.Longitudinal strain (LS) ,circumferential strain (CS) ,radial展开更多
In the design of geotechnical infrastructure,engineers have to deal with naturally occurring soils and rocks which are subjected to spatial variability as well as other uncertainties such as errors in measurement and ...In the design of geotechnical infrastructure,engineers have to deal with naturally occurring soils and rocks which are subjected to spatial variability as well as other uncertainties such as errors in measurement and in modeling methods.Reliability assessment which provides a systematic approach for quantifying the risk of failure has been shown to be a promising tool for solving these challenging geotechnical engineering problems.The method provides a more consistent measure of the level of safety or“structural reliability”through the evaluation of a reliability index and the associated“failure”probability,and is a method that satisfies the need to clearly convey safety issues to the public and regulatory authorities.Various methods for calculating the reliability of geotechnical infrastructures with regard to the assessment of the ultimate and serviceability limit states have been proposed by many researchers and these approaches include:the direct Monte Carlo Simulation,Bayesian and other sampling techniques,the first-order reliability method and the second-order reliability method,the random field method,the response surface method and other surrogate models with the related probabilistic procedures.In this special issue of Geoscience Frontiers,we assemble eleven invited papers which provide insights on the latest developments and challenges in applying probabilistic and reliability methods to geotechnical infrastructure design.展开更多
Wu-tou-tang was applied to treat rheumatoid arthritis,rheumatic arthritis,and joint pain for thousands of years.Aconiti Radix Cocta is the primary component of Wu-tou-tang,and Aconiti Radix and Pinelliae Rhizoma is on...Wu-tou-tang was applied to treat rheumatoid arthritis,rheumatic arthritis,and joint pain for thousands of years.Aconiti Radix Cocta is the primary component of Wu-tou-tang,and Aconiti Radix and Pinelliae Rhizoma is one of the famous combination taboos in traditional Chinese medicine.A urinary metabonomics method based on the ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry（UPLC-Q-TOF-MS） had been established to quantify the changes of the endogenous metabolites in the urine of adjuvant-induced arthritis rats treated by Wutou-tang and Wu-tou-tang and Pinelliae Rhizoma（WP） co-decoctions.There was a clear separation between Wu-tou-tang and WP co-decoction treated groups in the PCA model.16 potential biomarkers had been identified which correlated with how Pinelliae Rhizoma influenced the therapeutic effect made by Wu-tou-tang.Results showed that it could reduce the therapeutic effects or make some side effects when Pinelliae Rhizoma is added in Wu-tou-tang.This is the first time to use metabonomics to investigate the reason of combination taboo.展开更多
Chinese has special quantifiers as a part of speech while English does not have independent quantifiers.To some degree,the difference comes from the different cultural backgrounds.
The most extensive set of information on the factorsaffecting mutation induction by chemical mutagens inmice has been obtained by use of the dominant lethalassay and the specific locus method.Dominant lethalmutations ...The most extensive set of information on the factorsaffecting mutation induction by chemical mutagens inmice has been obtained by use of the dominant lethalassay and the specific locus method.Dominant lethalmutations are caused by chromosomal aberrations,and they occur shortly before or after implantation.展开更多
Based on the properties of ordered weighted averaging (OWA) operator and regular increasing monotone (RIM) quantifier, three methods for generating monotonic OWA operator weights are proposed. They are geometric OWA o...Based on the properties of ordered weighted averaging (OWA) operator and regular increasing monotone (RIM) quantifier, three methods for generating monotonic OWA operator weights are proposed. They are geometric OWA operator weights, equidifferent OWA operator weights and the modified RIM quantifier OWA weights. Compared with most of the common OWA methods for generating weights, the methods proposed in this paper are more intuitive and efficient in computation. And as there are more than one solution in most cases, the decision maker can set some initial condition and chooses the appropriate solution in the real decision process, which increases the flexibility of decision making to some extent. All these three OWA methods for generating weights are illustrated by numerical examples.展开更多
In order to achieve the model-based fault monitoring and diagnosis,an accurate model for the rotor system is necessary to locate and quantify faults.Since the dynamic characteristics of a blade-rotor system is influen...In order to achieve the model-based fault monitoring and diagnosis,an accurate model for the rotor system is necessary to locate and quantify faults.Since the dynamic characteristics of a blade-rotor system is influenced by foundation flexibility,the modeling and dynamic analyses on the foundation were sequentially investigated.Firstly,the effect of element size on the model convergence was investigated using the forward difference quotient as the slope of the frequency difference,which found that the model converged when the element size refined to 4mm.Secondly,a modal analysis and a harmonic response analysis were performed to obtain the dynamic characteristics of the foundation structure.Finally,an optimization to the foundation utilizing an additional stiffener was conducted to reduce the foundation response and make the critical speed far away from the working frequency band of 20—50Hz.展开更多
As more and more sophisticated medical equipment being purchased by hospi-tals,the selection is becoming an increasingly complex and important process.Usu-ally there are three steps in the selection process: planning,...As more and more sophisticated medical equipment being purchased by hospi-tals,the selection is becoming an increasingly complex and important process.Usu-ally there are three steps in the selection process: planning,feasibility and model se-lection evaluation.Model selection evalution is the most complex stage.The consid-展开更多
Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET)have been widely applied to visualize the molecular activity in live cells with high spatiotemporal resolution.The enormous amount of...Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET)have been widely applied to visualize the molecular activity in live cells with high spatiotemporal resolution.The enormous amount of video images and the complex dynamics of signaling events present tremendous challenges for data analysis and demand the development of intelligent and automated imaging analysis methods specifically envisioned for the studies of live cell imaging.We have developed a general correlative FRET imaging method(CFIM)to quantify the subcellular coupling between an enzymatic activity and a phenotypic response in live cells,e.g.at focal adhesions(FAs).CFIM quantitatively evaluated the cause-effect relation-展开更多
Forced dissociation of selectin-ligand complex is crucial to such biological processes as leukocyte recruitment,thrombosis formation,as well as tumor metastasis<sup>[</sup>1].Although several assays and te...Forced dissociation of selectin-ligand complex is crucial to such biological processes as leukocyte recruitment,thrombosis formation,as well as tumor metastasis<sup>[</sup>1].Although several assays and techniques,e.g.,dynamic force spectroscopy（DFS）,have been applied to probe the complex at single-bond level,the discrepancies in the loading rate dependence of bond rupture force were found in the assays,presumably due to the different pathways in energy landscape and binding kinetics of molecular complexes<sup>[2]</sup>.However,the underlying mechanisms remain unclear.Here an optical trap（OT）assay was used to quantify the bond rupture at r<sub>f</sub>≤20 pN/s展开更多
Quantifying rock weathering processes,especially in ways of nondisturbance and on-site investigation,is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation.We...Quantifying rock weathering processes,especially in ways of nondisturbance and on-site investigation,is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation.We proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering process.Four artificial models were designed to select suitable metrics among over 20 parameters.To validate the efficiency of image analysis,we analyzed rocks from badlands in Nanxiong Basin,Southeast China,under three different ranges of temperature differences(TD)during cyclic wetting and drying(WD).Our results show that TDs can accelerate the disintegration rate,and even if there is only a 20℃ difference in the range of TDs,an apparent difference in fragment size was observed.Moreover,the shape of fragments became more round as the increasing number of cyclic treatments,and for samples that went through the same number of treatments,the larger the temperature difference,the more round the shape became.All that serves as another evidence for landscape evolution response to climatic warming.展开更多
[Objective] The aim was to study the current living situation of Yangtze finless porpoise, and explore the prediction of the number of Yangtze finless porpoise in next few years. [Method] Modified Leslie Model and Sil...[Objective] The aim was to study the current living situation of Yangtze finless porpoise, and explore the prediction of the number of Yangtze finless porpoise in next few years. [Method] Modified Leslie Model and Siler's Model was applied to estimate the number of Yangtze finless porpoise. [Result] Using the model,Yangtze finless porpoise will extinct in nearly 20 years. [Conclusion] The study provides a cautionary warning of the conservation of the freshwater cetacean species.展开更多
文摘Detrital geochronology fundamentally involves the quantification of major age ranges and their weights winthin an age distribution.This study presents a streamlined approach,modeling the age distribution of detrital zircons using a normal mixture model,and employs the Expectation-Maximization(EM)algorithm for precise estimations.A method is introduced to automatically select appropriate initial mean values for EM algorithm,enhancing its efficacy in detrital geochronology.This process entails multiple trials with varying numbers of age components leading to diverse k-component models.The model with the lowest Bayesian Information Criterion(BIC)is identified as the most suitable.For accurate component number and weight determination,a substantial sample size(n>200)is advisable. Our findings based on both synthetic and empirical datasets confirm that the normal mixture model,refined by the EM algorithm,reliably identifies key age parameters with minimal error.As a kind of probability density estimator,the normal mixture model offers a novel visualization tool for detrital data and an alternative foundation for KDE in calculating existing similarity metrics.Another focus of this study is the critical examination of quantitative metrics for comparing detrital zircon age patterns.Through a case study,this study demonstrates that metrics based on empirical cumulative probability distribution(such as K-S and Kuiper statistics)may lead to erroneous conclusions.The employment of the Kullback-Leibler(KL)divergence,a metric grounded in probability density estimation,is proposed.Reference critical values,simulated via the Monte Carlo method,provide more objective benchmarks for these quantitative metrics. All methodologies discussed are encapsulated in a series of MATLAB scripts,available as open-source code and a standalone application,facilitating wider adoption and application in the field.
文摘Spectral quantitative fingerprinting including ultraviolet (UV) and Fourier transform infrared (FT-IR) coupled with combustion heat (CH) analytical techniques was employed and compared for rapid screening quality grade and discriminating San-Huang Tablets (SHT) of different commercial brands. The systematic quantified fingerprint method (SQFM) was applied to evaluate, qualitatively and quantitatively, the quality consistency of the herbal preparation. It was possible to deduce that the quantitative similarity analysis by SQFM was enabled to make a good discrimination of the tested samples. It was a particularly useful method for the overall quality evaluation of herbal medicine and their preparations.
基金supported by the following:the National Natural Science Foundation of China(Nos.62405141 and 22479079)Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(No.NY222178).
文摘The hydrogen evolution reaction(HER)in electrochemical water splitting is crucial for green hydrogen production,yet its efficiency is limited by bubble dynamics at the electrode surface.Accumulated bubbles can block active sites,hinder mass transport,and increase local resistance,causing energy loss.Thus,precise bubble monitoring is crucial for understanding performance limitations and optimizing catalyst design.Conventional bubble monitoring techniques,such as optical microscopy,high-speed imaging,and electrochemical impedance,are constrained by real-time accuracy,complex post-processing,or signal interference at high current densities.Here,we present an in situ fiber optic sensing system that enables precise,real-time monitoring of bubble dynamics during HER.Unlike traditional methods,this system leverages the sensitivity and real-time capability of fiber optic sensors to quantify key parameters,such as growth rate,detachment rate,intake/output ratio,and detaching size.Its reliability and adaptability were validated using two different Pt/C-loaded carbon paper catalysts with distinct catalytic properties.Notably,the system also achieves a bubble detection limit of 79μm,which meets the spatial resolution requirements for monitoring bubble dynamics relevant to electrocatalytic activity in HER.This sensing platform establishes a practical framework for connecting interfacial gas evolution to electrochemical performance,offering valuable insight for optimizing HER efficiency through catalyst design.
基金Supported by National Natural Science Foundation of China,No.82200650Shanxi Provincial Clinical Research Center for Interventional Medicine,No.202204010501004+3 种基金the Precision Interventional Diagnosis and Treatment Technology Innovation Base for Cirrhosis and Portal Hypertension,No.YDZJSX20231B010the Natural Science Foundation of Shanxi Province,No.20210302124282 and No.202203021212046the Shanxi Province Higher Education“Billion Project Science and Technology Guidance Project”,No.2C622024120the National Natural Science Foundation of China Supporting Fund,No.Y82200650.
文摘BACKGROUND The impact of transjugular intrahepatic portosystemic shunt(TIPS)on liver and spleen stiffness remains unclear,as does the association between preoperative liver and spleen stiffness and prognosis following TIPS.AIM To investigate changes in liver and spleen stiffness after TIPS and examines the relationship between these parameters and the prognosis of post-TIPS patients.METHODS A total of 76 patients with liver cirrhosis and portal hypertension who underwent TIPS were included.Liver and spleen stiffness was assessed using the sound touch quantify(STQ)value,determined via point shear wave elastography in ultrasound imaging.Cox regression analysis was employed to evaluate the relationship between liver and spleen stiffness and cumulative survival in TIPS patients.RESULTS The liver STQ value demonstrated a marginally decreasing trend over time(P=0.052),while the spleen STQ value showed a significantly decreasing trend(P=0.025).Spleen STQ was positively correlated with portal pressure gradient(PPG)levels(rs=0.327,P=0.025).Cox regression analysis indicated that older age[hazard ratio(HR)=1.063,95%CI:0.997-1.133,P=0.060]and a higher liver STQ value(HR=1.051,95%CI:1.009-1.095,P=0.018)were associated with an increased mortality risk after TIPS.No significant correlation was found between liver or spleen stiffness and overt hepatic encephalopathy post-TIPS.The liver STQ value[area under the receiver operating characteristic curve(AUC)=0.724(95%CI:0.563-0.884)]showed superior predictive performance compared to the Child-Pugh score[AUC=0.699(95%CI:0.529-0.870)]and was comparable to the model for end-stage liver disease score[AUC=0.746(95%CI:0.591-0.902)].CONCLUSION Following TIPS,spleen stiffness exhibited a more pronounced change than liver stiffness and was positively associated with PPG.Preoperative liver stiffness serves as a prognostic indicator for survival in patients undergoing TIPS.
基金Project(51975169)supported by the National Natural Science Foundation of ChinaProject(LH2022E085)supported by the Natural Science Foundation of Heilongjiang Province,China。
文摘Efficient tool condition monitoring techniques help to realize intelligent management of tool life and reduce tool usage costs.In this paper,the influence of different wear degrees of ball-end milling cutters on the texture shape of machining tool marks is investigated,and a method is proposed for predicting the wear state(including the position and degree of tool wear)of ball-end milling cutters based on entropy measurement of tool mark texture images.Firstly,data samples are prepared through wear experiments,and the change law of the tool mark texture shape with the tool wear state is analyzed.Then,a two-dimensional sample entropy algorithm is developed to quantify the texture morphology.Finally,the processing parameters and tool attitude are integrated into the prediction process to predict the wear value and wear position of the ball end milling cutter.After testing,the correlation between the predicted value and the standard value of the proposed tool condition monitoring method reaches 95.32%,and the accuracy reaches 82.73%,indicating that the proposed method meets the requirement of tool condition monitoring.
文摘Objective To assess left ventricular (LV) strain by3-dimensional speckle tracking imaging (3D-STI) in patients with coronary heart disease (CHD) .Methods All subjects underwent invasive coronary angiography.2-dimensional and 3-dimensional echocardiography were performed in 52 subjects with suspected CHD.Longitudinal strain (LS) ,circumferential strain (CS) ,radial
文摘In the design of geotechnical infrastructure,engineers have to deal with naturally occurring soils and rocks which are subjected to spatial variability as well as other uncertainties such as errors in measurement and in modeling methods.Reliability assessment which provides a systematic approach for quantifying the risk of failure has been shown to be a promising tool for solving these challenging geotechnical engineering problems.The method provides a more consistent measure of the level of safety or“structural reliability”through the evaluation of a reliability index and the associated“failure”probability,and is a method that satisfies the need to clearly convey safety issues to the public and regulatory authorities.Various methods for calculating the reliability of geotechnical infrastructures with regard to the assessment of the ultimate and serviceability limit states have been proposed by many researchers and these approaches include:the direct Monte Carlo Simulation,Bayesian and other sampling techniques,the first-order reliability method and the second-order reliability method,the random field method,the response surface method and other surrogate models with the related probabilistic procedures.In this special issue of Geoscience Frontiers,we assemble eleven invited papers which provide insights on the latest developments and challenges in applying probabilistic and reliability methods to geotechnical infrastructure design.
基金supported by the National Basic Research Program of China (973 Program,Nos.2011CB505300,2011CB505305)
文摘Wu-tou-tang was applied to treat rheumatoid arthritis,rheumatic arthritis,and joint pain for thousands of years.Aconiti Radix Cocta is the primary component of Wu-tou-tang,and Aconiti Radix and Pinelliae Rhizoma is one of the famous combination taboos in traditional Chinese medicine.A urinary metabonomics method based on the ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry（UPLC-Q-TOF-MS） had been established to quantify the changes of the endogenous metabolites in the urine of adjuvant-induced arthritis rats treated by Wutou-tang and Wu-tou-tang and Pinelliae Rhizoma（WP） co-decoctions.There was a clear separation between Wu-tou-tang and WP co-decoction treated groups in the PCA model.16 potential biomarkers had been identified which correlated with how Pinelliae Rhizoma influenced the therapeutic effect made by Wu-tou-tang.Results showed that it could reduce the therapeutic effects or make some side effects when Pinelliae Rhizoma is added in Wu-tou-tang.This is the first time to use metabonomics to investigate the reason of combination taboo.
文摘Chinese has special quantifiers as a part of speech while English does not have independent quantifiers.To some degree,the difference comes from the different cultural backgrounds.
文摘The most extensive set of information on the factorsaffecting mutation induction by chemical mutagens inmice has been obtained by use of the dominant lethalassay and the specific locus method.Dominant lethalmutations are caused by chromosomal aberrations,and they occur shortly before or after implantation.
文摘Based on the properties of ordered weighted averaging (OWA) operator and regular increasing monotone (RIM) quantifier, three methods for generating monotonic OWA operator weights are proposed. They are geometric OWA operator weights, equidifferent OWA operator weights and the modified RIM quantifier OWA weights. Compared with most of the common OWA methods for generating weights, the methods proposed in this paper are more intuitive and efficient in computation. And as there are more than one solution in most cases, the decision maker can set some initial condition and chooses the appropriate solution in the real decision process, which increases the flexibility of decision making to some extent. All these three OWA methods for generating weights are illustrated by numerical examples.
基金supported by the National Key Research and Development Plan(No.2016YFF0203300)
文摘In order to achieve the model-based fault monitoring and diagnosis,an accurate model for the rotor system is necessary to locate and quantify faults.Since the dynamic characteristics of a blade-rotor system is influenced by foundation flexibility,the modeling and dynamic analyses on the foundation were sequentially investigated.Firstly,the effect of element size on the model convergence was investigated using the forward difference quotient as the slope of the frequency difference,which found that the model converged when the element size refined to 4mm.Secondly,a modal analysis and a harmonic response analysis were performed to obtain the dynamic characteristics of the foundation structure.Finally,an optimization to the foundation utilizing an additional stiffener was conducted to reduce the foundation response and make the critical speed far away from the working frequency band of 20—50Hz.
文摘As more and more sophisticated medical equipment being purchased by hospi-tals,the selection is becoming an increasingly complex and important process.Usu-ally there are three steps in the selection process: planning,feasibility and model se-lection evaluation.Model selection evalution is the most complex stage.The consid-
文摘Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET)have been widely applied to visualize the molecular activity in live cells with high spatiotemporal resolution.The enormous amount of video images and the complex dynamics of signaling events present tremendous challenges for data analysis and demand the development of intelligent and automated imaging analysis methods specifically envisioned for the studies of live cell imaging.We have developed a general correlative FRET imaging method(CFIM)to quantify the subcellular coupling between an enzymatic activity and a phenotypic response in live cells,e.g.at focal adhesions(FAs).CFIM quantitatively evaluated the cause-effect relation-
基金supported by National Natural Science Foundation of China grants 10902117, 31230027,30730032,and 10332060
文摘Forced dissociation of selectin-ligand complex is crucial to such biological processes as leukocyte recruitment,thrombosis formation,as well as tumor metastasis<sup>[</sup>1].Although several assays and techniques,e.g.,dynamic force spectroscopy（DFS）,have been applied to probe the complex at single-bond level,the discrepancies in the loading rate dependence of bond rupture force were found in the assays,presumably due to the different pathways in energy landscape and binding kinetics of molecular complexes<sup>[2]</sup>.However,the underlying mechanisms remain unclear.Here an optical trap（OT）assay was used to quantify the bond rupture at r<sub>f</sub>≤20 pN/s
基金funded by the Natural Science Foundation of China(Grants 41901005)financial support from China Scholarship Council[grant number CSC201806995083]supported by the Ministry of Education,Science and Technological Development,Republic of Serbia(Grant No.451-039/2021-14/200026,451-03-9/2021-14/200168 and 451-03-9/2021-14/200358)。
文摘Quantifying rock weathering processes,especially in ways of nondisturbance and on-site investigation,is one of the most critical tasks in predicting rocks erosion rates and understanding the sediment transportation.We proposed a more reproducible approach to test how image analysis can quantify the changes in the size and shape of fragments during the weathering process.Four artificial models were designed to select suitable metrics among over 20 parameters.To validate the efficiency of image analysis,we analyzed rocks from badlands in Nanxiong Basin,Southeast China,under three different ranges of temperature differences(TD)during cyclic wetting and drying(WD).Our results show that TDs can accelerate the disintegration rate,and even if there is only a 20℃ difference in the range of TDs,an apparent difference in fragment size was observed.Moreover,the shape of fragments became more round as the increasing number of cyclic treatments,and for samples that went through the same number of treatments,the larger the temperature difference,the more round the shape became.All that serves as another evidence for landscape evolution response to climatic warming.
文摘[Objective] The aim was to study the current living situation of Yangtze finless porpoise, and explore the prediction of the number of Yangtze finless porpoise in next few years. [Method] Modified Leslie Model and Siler's Model was applied to estimate the number of Yangtze finless porpoise. [Result] Using the model,Yangtze finless porpoise will extinct in nearly 20 years. [Conclusion] The study provides a cautionary warning of the conservation of the freshwater cetacean species.
