We use the variational method to extract the short periodic orbits of the Qi system within a certain topological length.The chaotic dynamical behaviors of the Qi system with five equilibria are analyzed by the means o...We use the variational method to extract the short periodic orbits of the Qi system within a certain topological length.The chaotic dynamical behaviors of the Qi system with five equilibria are analyzed by the means of phase portraits,Lyapunov exponents,and Poincarémaps.Based on several periodic orbits with different sizes and shapes,they are encoded systematically with two letters or four letters for two different sets of parameters.The periodic orbits outside the attractor with complex topology are discovered by accident.In addition,the bifurcations of cycles and the bifurcations of equilibria in the Qi system are explored by different methods respectively.In this process,the rule of orbital period changing with parameters is also investigated.The calculation and classification method of periodic orbits in this study can be widely used in other similar low-dimensional dissipative systems.展开更多
Objective To evaluate the effectiveness and safety of the tonifying spleen and reinforcing Qi(TSRQ)therapy combined with thyroid hormone replacement therapy(THRT)for treating Hashimoto’s hypothyroidism.Methods From d...Objective To evaluate the effectiveness and safety of the tonifying spleen and reinforcing Qi(TSRQ)therapy combined with thyroid hormone replacement therapy(THRT)for treating Hashimoto’s hypothyroidism.Methods From database foundation to January 14,2025,PubMed,Web of Science,Cochrane,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data,China Science and Technology Journal Database(VIP),and China Biomedical Literature Database(CBM)were searched for relevant information.Randomized clinical trials(RCTs)evaluating the efficacy and safety of TSRQ therapy combined with THRT for Hashimoto’s hypothyroidism were eligible for inclusion.Following quality assessment,data were analyzed using Stata 15.1 to conduct a meta-analysis and systematic review.Subgroup analysis was used to identify the sources of heterogeneity.The Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was adopted to evaluate the certainty of the evidence.Results This study included 30 RCTs,comprising 2687 patients with Hashimoto’s hypothyroidism.Overall methodological quality was acceptable,with no studies exhibiting a high risk of bias.Meta-analysis demonstrated that TSRQ therapy combined with THRT significantly enhanced serum free triiodothyronine(fT3)levels[standardized mean difference(SMD)=0.76,95%confidence interval(CI):0.57 to 0.94,P<0.001]and free thyroxine(fT4)levels(SMD=0.86,95%CI:0.61 to 1.11,P<0.001),while reducing thyroid-stimulating hormone(TSH)levels(SMD=–0.99,95%CI:–1.20 to–0.78,P<0.001)compared with THRT alone.Furthermore,the combination therapy significantly decreased anti-thyroid peroxidase antibody(TPOAb)levels(SMD=–1.46,95%CI:–1.79 to–1.13,P<0.001)and anti-thyroglobulin antibody(TgAb)levels(SMD=–1.46,95%CI:–1.80 to–1.11,P<0.001).TSRQ therapy did not adversely impact the safety profile of THRT.However,while some sources of heterogeneity have been identified(e.g.,specific detection methodologies,I²=0.0%,P=0.938),there remains a portion of unexplained heterogeneity(e.g.,publication year,I²=93.4%,P<0.001),which has undermined confidence in these pooled estimates.The evidence ratings for fT3,fT4,and TSH were limited,and those for TPOAb and TgAb were even more limited.Conclusion TSRQ therapy combined with THRT may strengthen thyroid function and modulate immune dysregulation in patients with Hashimoto’s hypothyroidism without increasing adverse event incidence.展开更多
This study makes an in-depth exploration of the core pathogenesis of chronic atrophic gastritis,Qi Deficiency with Stagnation,to systematically interpret it within the theoretical framework of Achieving Central Harmon...This study makes an in-depth exploration of the core pathogenesis of chronic atrophic gastritis,Qi Deficiency with Stagnation,to systematically interpret it within the theoretical framework of Achieving Central Harmony,and to provide a treatment plan.Professor Li Tingquan believes that the occurrence and development of chronic atrophic gastritis(CAG)is fundamentally a process of harmony imbalance of the spleen and stomach.Its specific manifestation lies in the interaction between qi deficiency and stagnation,namely,spleen deficiency as the root cause,and qi stagnation,phlegm-dampness,and blood stasis obstructing the middle energizer as the secondary manifestations.These factors are mutually causal and interact with one another.Based on this,he proposed a four-step method to treat the disease:eliminating pathogenic factors,harmonizing the spleen and stomach,activating blood circulation to resolve stasis,and tonifying the kidney to generate blood(metaphorically described as"closing the mountains to cultivate forests and thicken the soil,breeding seeds and irrigating for stomach recovery").This approach aims to restore the harmonious state of the middle energizer,providing a complete clinical framework of theory,principle,formula,and herbs for the prevention and treatment of CAG.展开更多
Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various phy...Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various physiological functions)and“Yin”(it represents the material foundation of the human body.It plays a role in nourishing,moistening,and cooling the body).Notoginseng Radix et Rhizoma(NRR)is recognized for its properties of resolving blood stasis(it refers to a pathological condition characterized by impaired or stagnant blood circulation within the body).Changes in the compatibility ratio of these herbs often lead to variations in their chemical composition and efficacy.However,the specific alterations in chemical composition and efficacy resulting from compatibility adjustments remain unclear.We aimed to compare the material basis and their effects of different compatibility ratios of PQR and NRR on“Qi”deficiency and blood stasis syndrome(QBS).Methods:This study employed UPLC-Q/TOF-MS to identify effective compounds in the compatibility of PQR and NRR and utilized UPLC-TQ-MS/MS to analyze the dissolution of 16 saponins in PQR and NRR at 9 different ratios.A rat model of QBS was established,and the efficacy of PQR and NRR in treating this syndrome was assessed using hemorheology and coagulation analyses.Results:The study results show that PQR and NRR exhibit significant efficacy,effectively reducing blood viscosity induced by platelet aggregation and lowering inflammatory markers such as IL-6,IL-10,TXB2 and ET associated with vascular injury.Moreover,this combination regulates ATP and ADP levels,enhances energy metabolism,and promotes overall health.A total of 104 compounds in the compatibility of PQR and NRR were identified.The ratios of 1:2 and 1:3 showed the highest total saponin content,but the ratio of 1:1 demonstrated a superior pharmacological effect for the treatment of QBS.Conclusion:In summary,the compatibility of PQR and NRR not only shows the complex interactions between traditional Chinese medicinal materials,but also provides a new idea and method for the treatment of QBS.展开更多
Qì Gōng is a type of exercise that involves meditation and is used for health. With a background from the martial arts, it is known also as an auto healing exercise with three main elements according to Traditio...Qì Gōng is a type of exercise that involves meditation and is used for health. With a background from the martial arts, it is known also as an auto healing exercise with three main elements according to Traditional Chinese Medicine (TCM): body focus (posture and movement), breathing and mind focus (meditative elements). Heart rate variability is a tool that allows us to measure the autonomic system velocity to detect and respond to unexpected stimuli. So our goal was to build a systematic review of Qi Gong and Heart rate variability. PUBMED, EBSCO and Science Direct data bases were searched. Key terms (MeSH) were Heart Rate Variability and Ch’i Kung OR Qi Gong with a 10-year filter. Four independent reviewers analyzed all articles and excluded duplicated articles, articles in Chinese and articles with no adherence to the subject. The end result was 5 studies selected. Our results showed no significant improvements in HRV with the practice of Qì Gōng, probably because of data heterogeneity. We found 5 types of Qì Gōng, 3 different instruments and different time intervals to measure HRV and 2 different age groups in the studies. We can conclude that there is evidence that Qì Gōng can improve HRV but studies that would use the same parameters are needed to further confirm that.展开更多
Objective:To evaluate whether the traditional Chinese medicine(TCM)theory of five circuits and six qi(FCSQ)is beneficial in terms of improving clinical effectiveness.Methods:Randomized controlled trials(RCTs)evaluatin...Objective:To evaluate whether the traditional Chinese medicine(TCM)theory of five circuits and six qi(FCSQ)is beneficial in terms of improving clinical effectiveness.Methods:Randomized controlled trials(RCTs)evaluating the clinical value of FCSQ theory were reviewed.Multiple databases(China Network Knowledge Infrastructure,Chinese Scienti fic Journals Database,Wanfang Data,SinoMed,Cochrane Library,PubMed,and Embase)weresystematically searched from inception to June 12,2018.Two authors independently extracted the data and performed a methodological quality assessment of the RCTs.RevMan 5.3 software was used for the data analysis.The effect sizes for the primary outcome measures were expressed as relative risks or mean differences with 95%confidence intervals.Results:A total of 13 RCTs were selected,involving 12 types of diseases and 4695 patients.The methodological quality of the RCTs was generally low.Five studies compared the effectiveness of TCM treatments guided by FCSQ theory with conventional TCM therapies,and the remaining eight studies compared the effectiveness of TCM treatments guided by FCSQ theory with biomedical treatments.All of the RCTs reported that the effectiveness of the treatment intervention was better than that of the intervention in the control group.Conclusion:Because of many methodological problems in existing clinical studies,it remains impossible to definitively conclude that FCSQ theory can improve clinical effectiveness.It is difficult to unify the clinical application of FCSQ theory.The feasibility and repeatability of FCSQas an intervention should be given more attention in future clinical research.Future work should also follow international norms for clinical research implementation and reporting to provide high-quality evidence for evaluating the clinical value of FCSQ theory.展开更多
[Objectives]To observe the effect of acupoint liquid nitrogen cryotherapy on the neuro-endocrine-immune network system of lung qi deficiency syndrome during the remission period of bronchial asthma and explore its pos...[Objectives]To observe the effect of acupoint liquid nitrogen cryotherapy on the neuro-endocrine-immune network system of lung qi deficiency syndrome during the remission period of bronchial asthma and explore its possible mechanism.[Methods]A total of 100 patients with bronchial asthma were randomly divided into control group and observation group,with 50 cases in each group.The control group was given budesonide spray inhalation treatment,combined with acupoint liquid nitrogen freezing treatment,twice a year for a course of treatment,followed up for 1 year.The other 50 healthy volunteers were included in the healthy group,and no treatment was given in the healthy group.Serum immunoglobulins A,G,E(IgA,IgG,IgE)were detected before and after treatment in each group,serum cytokines[interleukin-4(IL-4),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],plasma neurotransmitters[substance P(SP),vasoactive intestinal peptide(VIP)].[Results]Before treatment,compared with healthy group,the contents of IgA,IgG,IL-10,IFN-γand VIP in observation group and control group were decreased,while the contents of IgE,IL-4,TNF-αand SP were increased,with statistical significance(P<0.05).After treatment,compared with before treatment,IgA,IgG,IL-10,IFN-γand VIP contents in observation group and control group were increased(P<0.05),and observation group was higher than control group(P<0.05),IgE,IL-4 and SP contents in observation group and control group were decreased(P<0.05).The observation group was lower than the control group(P<0.05).[Conclusions]Acupoint liquid nitrogen cryotherapy may improve the immune function of the body,regulate the release of cytokines and regulate neuromediators,and thus play a role in the prevention and treatment of bronchial asthma.展开更多
The Chinese traditional aesthetic culture not only pay attention to the overall sense of He Xie （Harmony, 和谐）, and pay attention to a kind of artistic conception as Zi Wei （滋味）, Qi Yun （氣韵）, and YiJing （...The Chinese traditional aesthetic culture not only pay attention to the overall sense of He Xie （Harmony, 和谐）, and pay attention to a kind of artistic conception as Zi Wei （滋味）, Qi Yun （氣韵）, and YiJing （意境） as well. Mr. JI Xian-lin had tried to start from Zi Wei （滋味）, a new comprehension to open a new understanding on Chinese aesthetics. Hence, we embark from the Chinese aesthetic culture and its basic spirit, the humanistic connotation of Zi Wei （滋味）, which sounds with the basis, put forward it into a Music-Dance Spirit （乐舞精神） in Chinese art through this unique view, has made a new thinking to the Chinese traditional aesthetic artistic category system.展开更多
Taking the Qi and Yin deficiency syndrome as an example,the research method of pharmacology of syndrome management system was proposed.By means of text mining,systematic pharmacology and target analysis,to attempt to ...Taking the Qi and Yin deficiency syndrome as an example,the research method of pharmacology of syndrome management system was proposed.By means of text mining,systematic pharmacology and target analysis,to attempt to reveal the essence of the corresponding syndrome by studying the drugs and targets of Qi and Yin deficiency.Fourteen Chinese herbs treating Qi and Yin deficiency were retrieved and used more than 30 times,and 9,317 related targets were predicted.The common targets of action were 85.Topological analysis was carried out by using degree centrality,closeness centrality and betweenness centrality to confirm that estrogen receptor(ESR1),tumor necrosis factor(TNF),D(2)dopamine receptor(DRD2),vitamin D3 receptor(VDR),glucocorticoid receptor(NR3C1),acetylcholinesterase(ACHE)and endothelin-1(EDN1)were highly correlated with Qi and Yin deficiency syndrome.Through the target to find Qi and Yin deficiency syndrome corresponding to 17 categories of diseases.A new idea was provided for studying the biological essence of TCM clinical syndrome differentiation.展开更多
OBJECTIVE:To propose an automatic acupuncture robot system for performing acupuncture operations.METHODS:The acupuncture robot system consists of three components:automatic acupoint localization,acupuncture manipulati...OBJECTIVE:To propose an automatic acupuncture robot system for performing acupuncture operations.METHODS:The acupuncture robot system consists of three components:automatic acupoint localization,acupuncture manipulations,and De Qi sensation detection.The OptiTrack motion capture system is used to locate acupoints,which are then translated into coordinates in the robot control system.A flexible collaborative robot with an intelligent gripper is then used to perform acupuncture manipulations with high precision.In addition,a De Qi sensation detection system is proposed to evaluate the effect of acupuncture.To verify the stability of the designed acupuncture robot,acupoints'coordinates localized by the acupuncture robot are compared with the Gold Standard labeled by a professional acupuncturist using significant level tests.RESULTS:Through repeated experiments for eight acupoints,the acupuncture robot achieved a positioning error within 3.3 mm,which is within the allowable range of needle extraction and acupoint insertion.During needle insertion,the robot arm followed the prescribed trajectory with a mean deviation distance of 0.02 mm and a deviation angle of less than 0.15°.The results of the lifting thrusting operation in the Xingzhen process show that the mean acupuncture depth error of the designed acupuncture robot is approximately 2 mm,which is within the recommended depth range for the Xingzhen operation.In addition,the average detection accuracy of the De Qi keywords is 94.52%,which meets the requirements of acupuncture effect testing for different dialects.CONCLUSION:The proposed acupuncture robot system streamlines the acupuncture process,increases efficiency,and reduces practitioner fatigue,while also allowing for the quantification of acupuncture manipulations and evaluation of therapeutic effects.The development of an acupuncture robot system has the potential to revolutionize low back pain treatment and improve patient outcomes.展开更多
Objective To explore the clinical characteristics and methods for syndrome differentiation prediction,as well as to construct a predictive model for Qi deficiency and blood stasis syndrome in patients with acute ische...Objective To explore the clinical characteristics and methods for syndrome differentiation prediction,as well as to construct a predictive model for Qi deficiency and blood stasis syndrome in patients with acute ischemic stroke(AIS).Methods This study employed a retrospective case-control design to analyze patients with AIS who received inpatient treatment at the Neurology Department of The First Hospital of Hunan University of Chinese Medicine from January 1,2013 to December 31,2022.AIS patients meeting the diagnostic criteria for Qi deficiency and blood stasis syndrome were stratified into case group,while those without Qi deficiency and blood stasis syndrome were stratified into control group.The demographic characteristics(age and gender),clinical parameters[time from onset to admission,National Institutes of Health Stroke Scale(NIHSS)score,and blood pressure],past medical history,traditional Chinese medicine(TCM)diagnostic characteristics(tongue and pulse),neurological symptoms and signs,imaging findings[magnetic resonance imaging-diffusion weighted imaging(MRI-DWI)],and biochemical indicators of the two groups were collected and compared.The indicators with statistical difference(P<0.05)in univariate analysis were included in multivariate logistic regression analysis to evaluate their predictive value for the diagnosis of Qi deficiency and blood stasis syndrome,and the predictive model was constructed by receiver operating characteristic(ROC)curve analysis.Results The study included 1035 AIS patients,with 404 cases in case group and 631 cases in control group.Compared with control group,patients in case group were significantly older,had extended onset-to-admission time,lower diastolic blood pressure,and lower NIHSS scores(P<0.05).Case group showed lower incidence of hypertension history(P<0.05).Regarding tongue and pulse characteristics,pale and dark tongue colors,white tongue coating,fine pulse,astringent pulse,and sinking pulse were more common in case group.Imaging examinations demonstrated higher proportions of centrum semiovale infarction,cerebral atrophy,and vertebral artery stenosis in case group(P<0.05).Among biochemical indicators,case group showed higher proportions of elevated fasting blood glucose and glycated hemoglobin(HbA1c),while lower proportions of elevated white blood cell count,reduced hemoglobin,and reduced high-density lipoprotein cholesterol(HDL-C)(P<0.05).Multivariate logistic regression analysis identified significant predictors for Qi deficiency and blood stasis syndrome including:fine pulse[odds ratio(OR)=4.38],astringent pulse(OR=3.67),superficial sensory abnormalities(OR=1.86),centrum semiovale infarction(OR=1.57),cerebral atrophy(OR=1.55),vertebral artery stenosis(OR=1.62),and elevated HbA1c(OR=3.52).The ROC curve analysis of the comprehensive prediction model yielded an area under the curve(AUC)of 0.878[95%confidence interval(CI)=0.855-0.900].Conclusion This study finds out that Qi deficiency and blood stasis syndrome represents one of the primary types of AIS.Fine pulse,astringent pulse,superficial sensory abnormalities,centrum semiovale infarction,cerebral atrophy,vertebral artery stenosis,elevated blood glucose,elevated HbA1c,pale and dark tongue colors,and white tongue coating are key objective diagnostic indicators for the syndrome differentiation of AIS with Qi deficiency and blood stasis syndrome.Based on these indicators,a syndrome differentiation prediction model has been developed,offering a more objective basis for clinical diagnosis,and help to rapidly identify this syndrome in clinical practice and reduce misdiagnosis and missed diagnosis.展开更多
BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced stages.As a result,treatment often shifts from surgery to other therapies,with...BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced stages.As a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table method.The control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous sindilizumab.The observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei granules.Both groups underwent treatment cycles of 3 weeks,with a minimum of two cycles.The therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the groups.The objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P<0.05).After two treatment cycle,CD3+,CD4+,and CD4+/CD8+levels were higher in the observation group compared to the control group,while CD8+,regulatory T cells,and natural killer cells were lower(P<0.05).Additionally,the incidence of leukopenia,nausea,and vomiting was lower in observed group(P<0.05).No significant differences were observed in the incidence of other adverse reactions(P>0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.展开更多
Background:Qi pi pill(QPP),which contains Renshen,Baizhu,Fuling,Gancao,Chenpi,Shanyao,Lianzi,Shanzha,Liushenqu,Maiya,and Zexie,was recommended for preventing and treating COVID-19 in Shandong Province(China).However,t...Background:Qi pi pill(QPP),which contains Renshen,Baizhu,Fuling,Gancao,Chenpi,Shanyao,Lianzi,Shanzha,Liushenqu,Maiya,and Zexie,was recommended for preventing and treating COVID-19 in Shandong Province(China).However,the mechanism by which QPP treats infectious diseases remains unclear.This study aims to investigate the therapeutic effect of QPP in vitro and on acute influenza infection in mice,exploring its mechanism of action against influenza A virus(IAV).Methods:The in vitro activity of QPP was assessed using dose–response curve analysis and titer reduction assay,and its antiviral mechanism was identified in vitro by realtime polymerase chain reaction(PCR),time-of-addition,and enzymatic assays.The antiviral efficacy of QPP was further evaluated in vivo using BALB/c mice infected with IAV.At the same time,each single Chinese herbal medicine in QPP was evaluated to preliminarily identify those with antiviral effects.Results:In vitro results showed that QPP exhibited a higher potency antiviral effect against both influenza A and B viruses,inhibiting viral RNA replication and release by targeting RNA-dependent RNA polymerase and neuraminidase.Additionally,QPP significantly decreased the expression of inflammatory cytokines in A549 cells.In vivo study revealed that QPP significantly reduced the lung index and viral load in lung tissue of mice infected with IAV.Renshen,Gancao,Zexie,and Lianzi were the Chinese herbal medicines from QPP that showed anti-IAV activity.Conclusion:The antiviral activity of QPP targets IAV replication and release,cytokine modulation in host cells,and provides protection in mice with acute influenza infection.展开更多
Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January ...Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January 2025.The author confirmed this article’s proof on 23 January 2025 without any questions.But on 06 July 2025,the editorial team found,there was an error in Figure 8.Specifically,Figure 8E,Figure 8F and Figure 8G were mistakenly duplicated.The authors acknowledge that the original version of Figure 8 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.展开更多
Objective To elucidate the mechanism of Fuzheng Gankang Pill in treating combined allergic rhinitis and asthma syndrome(CARAS)with lung-spleen qi deficiency and wind-cold invading the lung syndrome using network pharm...Objective To elucidate the mechanism of Fuzheng Gankang Pill in treating combined allergic rhinitis and asthma syndrome(CARAS)with lung-spleen qi deficiency and wind-cold invading the lung syndrome using network pharmacology and molecular docking.MethodsThe active components and targets of the 13 herbs in Fuzheng Gankang Pill were retrieved from the TraditionalChinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)and HERB.A“core herb-active component-target"network was constructed using Cytoscape to screen core components.CARAS disease targets were obtained from Genecards,NationalCenter for Biotechnology Information(NCBI),and Online Mendelian Inheritance in Man(OMIM).Targets related to the clinical phenotypes of CARAS with lung-spleen qi deficiency and wind-cold invading the lung syndrome were retrieved from the Traditional ChineseMedicineSyndrome Ontology and Multidimensional Quantitative Association Calculation Platform.The intersection of CARAS disease targets and syndromerelated targets yielded CARAS disease-syndrome targets.The intersection of Fuzheng Gankang Pill component-related targets and CARAS disease-syndrome targets provided“disease-syndrome-formula”intersection targets.These targets were uploaded to the STRING database for protein-protein interaction(PPI)network analysis,with topological analysis identifying key targets.Metascape was used for Gene Ontology(GO)enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis.Molecular docking validation was performed using AutoDock Vina 1.1.2.Results The 13 core herbs of Fuzheng Gankang Pill contain a total of 200 active ingredients and 289 related targets.There are 2,412 disease targets for CARAS and 735 corresponding disease targets for the main and secondary symptoms of lung-spleen qi deficiency and wind-cold invading the lung.Through the Venn diagram,a total of 35 intersecting targets were obtained for Fuzheng Gankang Pill,CARAS,and the combination of lung-spleen qi deficiency and wind-cold invading the lung syndrome.Quercetin,Polygonatum sibiricum flavonoids,β-sitosterol,baicalein,kaempferol,etc.,are core components.PPI network analysis found that tumor necrosis factor(TNF),prostaglandin-endoperoxide synthase 2(PTGS2),interleukin(IL)-1β,IL-6,transforming growth factor beta 1(TGFβ1),BCL2,etc.,are the core targets for the compound to exert therapeutic effects.GO enrichment analysis showed that the 13 core drugs of Fuzheng Gankang Pill mainly participate in key biological processes such as positive regulation of protein modification,response to hormones,and negative regulation of cell population proliferation through protein kinases in areas such as membrane rafts,membrane microregions,plasma membrane protein complexes,and receptor com-plexes.KEGG enriched a total of 30 signaling pathways.Molecular docking shows that active ingredients such as quercetin and kaempferol bind stably toTNF(binding energy≤-9.0 kcal·mol^(-1))and PTGS2(≤-8.5kcal·mol^(-1)).Conclusion Fuzheng Gankang Pill may regulate biological processes such as cell apoptosis,tissue remodeling,inflammatory response,and immune response by acting on core targets such as TNF and PTGS2 through its core components quercetin,baicalein,β-sitosterol,baicalein,and kaempferol,thereby exerting therapeutic effects on CARAS with lung-spleen qi deficiency and wind-cold invading the lung syndrome.展开更多
Objective:To observe the therapeutic effect of Moist Burn Ointment combined with rotating moxibustion on patients with pressure ulcers and deficiency of both Qi and blood.Methods:40 patients with pressure ulcers and d...Objective:To observe the therapeutic effect of Moist Burn Ointment combined with rotating moxibustion on patients with pressure ulcers and deficiency of both Qi and blood.Methods:40 patients with pressure ulcers and deficiency of both Qi and blood were randomly divided into two groups from July 2024 to November 2025.Group A received Moist Burn Ointment combined with rotating moxibustion,while Group B received Moist Burn Ointment only.Results:Group A showed better efficacy,wound healing time,dressing change frequency,satisfaction,PUSH score,and adverse reaction indicators compared to Group B(P<0.05).Conclusion:The combination of Moist Burn Ointment and rotating moxibustion in the treatment of patients with pressure ulcers and deficiency of both Qi and blood can shorten wound healing time,reduce dressing change frequency,and alleviate the degree of pressure ulcers,which is safe and efficient.展开更多
Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12...Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.展开更多
Objectives:To propose a new idea of“lung ventilation and Qi regulation”for preventing and treating lung cancer,and to summarize the corresponding Tongfei Huajie prescription,as a systematic theoretical and practical...Objectives:To propose a new idea of“lung ventilation and Qi regulation”for preventing and treating lung cancer,and to summarize the corresponding Tongfei Huajie prescription,as a systematic theoretical and practical innovation.Methods:Based on the etiology and pathogenesis of lung cancer,the anatomy,physiology and pathology of the lung,and inspired by the ancient“Tuoyue”(bellows)theory,this study combined the clinical observation of ventilation issues in lung cancer patients.The Tongfei Huajie prescription was formulated following the classic principle of monarch(Jun),minister(Chen),assistant(Zuo),and guide(Shi),and was interpreted with modern pharmacological research.Results:A novel therapeutic concept of“lung ventilation and Qi regulation”was proposed.The corresponding Tongfei Huajie prescription was developed,which has the effects of ventilating the lung,expelling phlegm dampness,tonifying Qi,tonifying the kidney and spleen for lung health,soothing the liver and descending lung Qi,and clearing the heart and moistening the lung.Clinical application has achieved obvious curative effect.Conclusions:This work presents a systematic summary of the innovation in“theory,method,formula and herb”for lung cancer treatment,demonstrating the advantages of Traditional Chinese Medicine in this field.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12205257,11647085,and11647086)the Shanxi Province Science Foundation for Youths(Grant No.201901D211252)+1 种基金Fundamental Research Program of Shanxi Province(Grant No.202203021221095)the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi of China(Grant Nos.2019L0505,2019L0554,and 2019L0572)。
文摘We use the variational method to extract the short periodic orbits of the Qi system within a certain topological length.The chaotic dynamical behaviors of the Qi system with five equilibria are analyzed by the means of phase portraits,Lyapunov exponents,and Poincarémaps.Based on several periodic orbits with different sizes and shapes,they are encoded systematically with two letters or four letters for two different sets of parameters.The periodic orbits outside the attractor with complex topology are discovered by accident.In addition,the bifurcations of cycles and the bifurcations of equilibria in the Qi system are explored by different methods respectively.In this process,the rule of orbital period changing with parameters is also investigated.The calculation and classification method of periodic orbits in this study can be widely used in other similar low-dimensional dissipative systems.
基金National Natural Science Foundation of China(82305090)Shanghai Municipal Health Commission(20234Y0168)National Key Research and Development Program of China(2017YFC1703301)。
文摘Objective To evaluate the effectiveness and safety of the tonifying spleen and reinforcing Qi(TSRQ)therapy combined with thyroid hormone replacement therapy(THRT)for treating Hashimoto’s hypothyroidism.Methods From database foundation to January 14,2025,PubMed,Web of Science,Cochrane,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data,China Science and Technology Journal Database(VIP),and China Biomedical Literature Database(CBM)were searched for relevant information.Randomized clinical trials(RCTs)evaluating the efficacy and safety of TSRQ therapy combined with THRT for Hashimoto’s hypothyroidism were eligible for inclusion.Following quality assessment,data were analyzed using Stata 15.1 to conduct a meta-analysis and systematic review.Subgroup analysis was used to identify the sources of heterogeneity.The Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was adopted to evaluate the certainty of the evidence.Results This study included 30 RCTs,comprising 2687 patients with Hashimoto’s hypothyroidism.Overall methodological quality was acceptable,with no studies exhibiting a high risk of bias.Meta-analysis demonstrated that TSRQ therapy combined with THRT significantly enhanced serum free triiodothyronine(fT3)levels[standardized mean difference(SMD)=0.76,95%confidence interval(CI):0.57 to 0.94,P<0.001]and free thyroxine(fT4)levels(SMD=0.86,95%CI:0.61 to 1.11,P<0.001),while reducing thyroid-stimulating hormone(TSH)levels(SMD=–0.99,95%CI:–1.20 to–0.78,P<0.001)compared with THRT alone.Furthermore,the combination therapy significantly decreased anti-thyroid peroxidase antibody(TPOAb)levels(SMD=–1.46,95%CI:–1.79 to–1.13,P<0.001)and anti-thyroglobulin antibody(TgAb)levels(SMD=–1.46,95%CI:–1.80 to–1.11,P<0.001).TSRQ therapy did not adversely impact the safety profile of THRT.However,while some sources of heterogeneity have been identified(e.g.,specific detection methodologies,I²=0.0%,P=0.938),there remains a portion of unexplained heterogeneity(e.g.,publication year,I²=93.4%,P<0.001),which has undermined confidence in these pooled estimates.The evidence ratings for fT3,fT4,and TSH were limited,and those for TPOAb and TgAb were even more limited.Conclusion TSRQ therapy combined with THRT may strengthen thyroid function and modulate immune dysregulation in patients with Hashimoto’s hypothyroidism without increasing adverse event incidence.
基金Supported by General Project of Shanxi Administration of Traditional Chinese Medicine(2023ZYYA007&2024ZYY2D009)Young Scientists Project of Shanxi Provincial Department of Science and Technology(202203021212026)Scientific and Technological Innovation Capacity Cultivation Program for Basic and Clinical Cooperative Research Project of Shanxi University of Chinese Medicine(2024PY-JL-23-01).
文摘This study makes an in-depth exploration of the core pathogenesis of chronic atrophic gastritis,Qi Deficiency with Stagnation,to systematically interpret it within the theoretical framework of Achieving Central Harmony,and to provide a treatment plan.Professor Li Tingquan believes that the occurrence and development of chronic atrophic gastritis(CAG)is fundamentally a process of harmony imbalance of the spleen and stomach.Its specific manifestation lies in the interaction between qi deficiency and stagnation,namely,spleen deficiency as the root cause,and qi stagnation,phlegm-dampness,and blood stasis obstructing the middle energizer as the secondary manifestations.These factors are mutually causal and interact with one another.Based on this,he proposed a four-step method to treat the disease:eliminating pathogenic factors,harmonizing the spleen and stomach,activating blood circulation to resolve stasis,and tonifying the kidney to generate blood(metaphorically described as"closing the mountains to cultivate forests and thicken the soil,breeding seeds and irrigating for stomach recovery").This approach aims to restore the harmonious state of the middle energizer,providing a complete clinical framework of theory,principle,formula,and herbs for the prevention and treatment of CAG.
基金funded by the Entrusted service project of Shaanxi Administration of Traditional Chinese Medicine(ZYJXG-L23001)2023 Sanqin Talent Special Support Program Innovation and Entrepreneurship Team Project,and Sci-Tech Innovation Talent System Construction Program of Shaanxi University of Chinese Medicine(2023).
文摘Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various physiological functions)and“Yin”(it represents the material foundation of the human body.It plays a role in nourishing,moistening,and cooling the body).Notoginseng Radix et Rhizoma(NRR)is recognized for its properties of resolving blood stasis(it refers to a pathological condition characterized by impaired or stagnant blood circulation within the body).Changes in the compatibility ratio of these herbs often lead to variations in their chemical composition and efficacy.However,the specific alterations in chemical composition and efficacy resulting from compatibility adjustments remain unclear.We aimed to compare the material basis and their effects of different compatibility ratios of PQR and NRR on“Qi”deficiency and blood stasis syndrome(QBS).Methods:This study employed UPLC-Q/TOF-MS to identify effective compounds in the compatibility of PQR and NRR and utilized UPLC-TQ-MS/MS to analyze the dissolution of 16 saponins in PQR and NRR at 9 different ratios.A rat model of QBS was established,and the efficacy of PQR and NRR in treating this syndrome was assessed using hemorheology and coagulation analyses.Results:The study results show that PQR and NRR exhibit significant efficacy,effectively reducing blood viscosity induced by platelet aggregation and lowering inflammatory markers such as IL-6,IL-10,TXB2 and ET associated with vascular injury.Moreover,this combination regulates ATP and ADP levels,enhances energy metabolism,and promotes overall health.A total of 104 compounds in the compatibility of PQR and NRR were identified.The ratios of 1:2 and 1:3 showed the highest total saponin content,but the ratio of 1:1 demonstrated a superior pharmacological effect for the treatment of QBS.Conclusion:In summary,the compatibility of PQR and NRR not only shows the complex interactions between traditional Chinese medicinal materials,but also provides a new idea and method for the treatment of QBS.
文摘Qì Gōng is a type of exercise that involves meditation and is used for health. With a background from the martial arts, it is known also as an auto healing exercise with three main elements according to Traditional Chinese Medicine (TCM): body focus (posture and movement), breathing and mind focus (meditative elements). Heart rate variability is a tool that allows us to measure the autonomic system velocity to detect and respond to unexpected stimuli. So our goal was to build a systematic review of Qi Gong and Heart rate variability. PUBMED, EBSCO and Science Direct data bases were searched. Key terms (MeSH) were Heart Rate Variability and Ch’i Kung OR Qi Gong with a 10-year filter. Four independent reviewers analyzed all articles and excluded duplicated articles, articles in Chinese and articles with no adherence to the subject. The end result was 5 studies selected. Our results showed no significant improvements in HRV with the practice of Qì Gōng, probably because of data heterogeneity. We found 5 types of Qì Gōng, 3 different instruments and different time intervals to measure HRV and 2 different age groups in the studies. We can conclude that there is evidence that Qì Gōng can improve HRV but studies that would use the same parameters are needed to further confirm that.
基金supported by the National Natural Science Foundation of China(81503678).
文摘Objective:To evaluate whether the traditional Chinese medicine(TCM)theory of five circuits and six qi(FCSQ)is beneficial in terms of improving clinical effectiveness.Methods:Randomized controlled trials(RCTs)evaluating the clinical value of FCSQ theory were reviewed.Multiple databases(China Network Knowledge Infrastructure,Chinese Scienti fic Journals Database,Wanfang Data,SinoMed,Cochrane Library,PubMed,and Embase)weresystematically searched from inception to June 12,2018.Two authors independently extracted the data and performed a methodological quality assessment of the RCTs.RevMan 5.3 software was used for the data analysis.The effect sizes for the primary outcome measures were expressed as relative risks or mean differences with 95%confidence intervals.Results:A total of 13 RCTs were selected,involving 12 types of diseases and 4695 patients.The methodological quality of the RCTs was generally low.Five studies compared the effectiveness of TCM treatments guided by FCSQ theory with conventional TCM therapies,and the remaining eight studies compared the effectiveness of TCM treatments guided by FCSQ theory with biomedical treatments.All of the RCTs reported that the effectiveness of the treatment intervention was better than that of the intervention in the control group.Conclusion:Because of many methodological problems in existing clinical studies,it remains impossible to definitively conclude that FCSQ theory can improve clinical effectiveness.It is difficult to unify the clinical application of FCSQ theory.The feasibility and repeatability of FCSQas an intervention should be given more attention in future clinical research.Future work should also follow international norms for clinical research implementation and reporting to provide high-quality evidence for evaluating the clinical value of FCSQ theory.
基金Supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region(2021D01C182).
文摘[Objectives]To observe the effect of acupoint liquid nitrogen cryotherapy on the neuro-endocrine-immune network system of lung qi deficiency syndrome during the remission period of bronchial asthma and explore its possible mechanism.[Methods]A total of 100 patients with bronchial asthma were randomly divided into control group and observation group,with 50 cases in each group.The control group was given budesonide spray inhalation treatment,combined with acupoint liquid nitrogen freezing treatment,twice a year for a course of treatment,followed up for 1 year.The other 50 healthy volunteers were included in the healthy group,and no treatment was given in the healthy group.Serum immunoglobulins A,G,E(IgA,IgG,IgE)were detected before and after treatment in each group,serum cytokines[interleukin-4(IL-4),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],plasma neurotransmitters[substance P(SP),vasoactive intestinal peptide(VIP)].[Results]Before treatment,compared with healthy group,the contents of IgA,IgG,IL-10,IFN-γand VIP in observation group and control group were decreased,while the contents of IgE,IL-4,TNF-αand SP were increased,with statistical significance(P<0.05).After treatment,compared with before treatment,IgA,IgG,IL-10,IFN-γand VIP contents in observation group and control group were increased(P<0.05),and observation group was higher than control group(P<0.05),IgE,IL-4 and SP contents in observation group and control group were decreased(P<0.05).The observation group was lower than the control group(P<0.05).[Conclusions]Acupoint liquid nitrogen cryotherapy may improve the immune function of the body,regulate the release of cytokines and regulate neuromediators,and thus play a role in the prevention and treatment of bronchial asthma.
文摘The Chinese traditional aesthetic culture not only pay attention to the overall sense of He Xie （Harmony, 和谐）, and pay attention to a kind of artistic conception as Zi Wei （滋味）, Qi Yun （氣韵）, and YiJing （意境） as well. Mr. JI Xian-lin had tried to start from Zi Wei （滋味）, a new comprehension to open a new understanding on Chinese aesthetics. Hence, we embark from the Chinese aesthetic culture and its basic spirit, the humanistic connotation of Zi Wei （滋味）, which sounds with the basis, put forward it into a Music-Dance Spirit （乐舞精神） in Chinese art through this unique view, has made a new thinking to the Chinese traditional aesthetic artistic category system.
文摘Taking the Qi and Yin deficiency syndrome as an example,the research method of pharmacology of syndrome management system was proposed.By means of text mining,systematic pharmacology and target analysis,to attempt to reveal the essence of the corresponding syndrome by studying the drugs and targets of Qi and Yin deficiency.Fourteen Chinese herbs treating Qi and Yin deficiency were retrieved and used more than 30 times,and 9,317 related targets were predicted.The common targets of action were 85.Topological analysis was carried out by using degree centrality,closeness centrality and betweenness centrality to confirm that estrogen receptor(ESR1),tumor necrosis factor(TNF),D(2)dopamine receptor(DRD2),vitamin D3 receptor(VDR),glucocorticoid receptor(NR3C1),acetylcholinesterase(ACHE)and endothelin-1(EDN1)were highly correlated with Qi and Yin deficiency syndrome.Through the target to find Qi and Yin deficiency syndrome corresponding to 17 categories of diseases.A new idea was provided for studying the biological essence of TCM clinical syndrome differentiation.
基金Modernization of Traditional Chinese Medicine Project of National Key R&D Program of China:The construction of the theoretical system of Traditional Chinese Medicine nonpharmacological therapy based on body surface stimulation(2023YFC3502704)Sichuan Provincial Science and Technology Program Project:Research and Development of Chinese Medicine Intelligent Tongue Diagnosis Equipment for Digestive System Chinese Medicine Advantageous Diseases(2023YFS0327)+2 种基金Research and Development of Chinese Medicine Intelligent Detection System for Intestinal Functions(2024YFFK0044)Research and Application of Chinese Medicine Diagnosis and Treatment Program for Herpes Zoster Treated by Shu Pai Fire Acupuncture(2024YFFK0089)Major Research and Development Project of The China Academy of Chinese Medical Sciences Innovation:Construction and application of the theoretical research mode of Traditional Chinese Medicine diagnosis and treatment of modern diseases(CI2021A00104)。
文摘OBJECTIVE:To propose an automatic acupuncture robot system for performing acupuncture operations.METHODS:The acupuncture robot system consists of three components:automatic acupoint localization,acupuncture manipulations,and De Qi sensation detection.The OptiTrack motion capture system is used to locate acupoints,which are then translated into coordinates in the robot control system.A flexible collaborative robot with an intelligent gripper is then used to perform acupuncture manipulations with high precision.In addition,a De Qi sensation detection system is proposed to evaluate the effect of acupuncture.To verify the stability of the designed acupuncture robot,acupoints'coordinates localized by the acupuncture robot are compared with the Gold Standard labeled by a professional acupuncturist using significant level tests.RESULTS:Through repeated experiments for eight acupoints,the acupuncture robot achieved a positioning error within 3.3 mm,which is within the allowable range of needle extraction and acupoint insertion.During needle insertion,the robot arm followed the prescribed trajectory with a mean deviation distance of 0.02 mm and a deviation angle of less than 0.15°.The results of the lifting thrusting operation in the Xingzhen process show that the mean acupuncture depth error of the designed acupuncture robot is approximately 2 mm,which is within the recommended depth range for the Xingzhen operation.In addition,the average detection accuracy of the De Qi keywords is 94.52%,which meets the requirements of acupuncture effect testing for different dialects.CONCLUSION:The proposed acupuncture robot system streamlines the acupuncture process,increases efficiency,and reduces practitioner fatigue,while also allowing for the quantification of acupuncture manipulations and evaluation of therapeutic effects.The development of an acupuncture robot system has the potential to revolutionize low back pain treatment and improve patient outcomes.
基金National Natural Science Foundation of China(U22A20377)Natural Science Foundation of Hunan Province of China(23C0168).
文摘Objective To explore the clinical characteristics and methods for syndrome differentiation prediction,as well as to construct a predictive model for Qi deficiency and blood stasis syndrome in patients with acute ischemic stroke(AIS).Methods This study employed a retrospective case-control design to analyze patients with AIS who received inpatient treatment at the Neurology Department of The First Hospital of Hunan University of Chinese Medicine from January 1,2013 to December 31,2022.AIS patients meeting the diagnostic criteria for Qi deficiency and blood stasis syndrome were stratified into case group,while those without Qi deficiency and blood stasis syndrome were stratified into control group.The demographic characteristics(age and gender),clinical parameters[time from onset to admission,National Institutes of Health Stroke Scale(NIHSS)score,and blood pressure],past medical history,traditional Chinese medicine(TCM)diagnostic characteristics(tongue and pulse),neurological symptoms and signs,imaging findings[magnetic resonance imaging-diffusion weighted imaging(MRI-DWI)],and biochemical indicators of the two groups were collected and compared.The indicators with statistical difference(P<0.05)in univariate analysis were included in multivariate logistic regression analysis to evaluate their predictive value for the diagnosis of Qi deficiency and blood stasis syndrome,and the predictive model was constructed by receiver operating characteristic(ROC)curve analysis.Results The study included 1035 AIS patients,with 404 cases in case group and 631 cases in control group.Compared with control group,patients in case group were significantly older,had extended onset-to-admission time,lower diastolic blood pressure,and lower NIHSS scores(P<0.05).Case group showed lower incidence of hypertension history(P<0.05).Regarding tongue and pulse characteristics,pale and dark tongue colors,white tongue coating,fine pulse,astringent pulse,and sinking pulse were more common in case group.Imaging examinations demonstrated higher proportions of centrum semiovale infarction,cerebral atrophy,and vertebral artery stenosis in case group(P<0.05).Among biochemical indicators,case group showed higher proportions of elevated fasting blood glucose and glycated hemoglobin(HbA1c),while lower proportions of elevated white blood cell count,reduced hemoglobin,and reduced high-density lipoprotein cholesterol(HDL-C)(P<0.05).Multivariate logistic regression analysis identified significant predictors for Qi deficiency and blood stasis syndrome including:fine pulse[odds ratio(OR)=4.38],astringent pulse(OR=3.67),superficial sensory abnormalities(OR=1.86),centrum semiovale infarction(OR=1.57),cerebral atrophy(OR=1.55),vertebral artery stenosis(OR=1.62),and elevated HbA1c(OR=3.52).The ROC curve analysis of the comprehensive prediction model yielded an area under the curve(AUC)of 0.878[95%confidence interval(CI)=0.855-0.900].Conclusion This study finds out that Qi deficiency and blood stasis syndrome represents one of the primary types of AIS.Fine pulse,astringent pulse,superficial sensory abnormalities,centrum semiovale infarction,cerebral atrophy,vertebral artery stenosis,elevated blood glucose,elevated HbA1c,pale and dark tongue colors,and white tongue coating are key objective diagnostic indicators for the syndrome differentiation of AIS with Qi deficiency and blood stasis syndrome.Based on these indicators,a syndrome differentiation prediction model has been developed,offering a more objective basis for clinical diagnosis,and help to rapidly identify this syndrome in clinical practice and reduce misdiagnosis and missed diagnosis.
文摘BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced stages.As a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table method.The control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous sindilizumab.The observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei granules.Both groups underwent treatment cycles of 3 weeks,with a minimum of two cycles.The therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the groups.The objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P<0.05).After two treatment cycle,CD3+,CD4+,and CD4+/CD8+levels were higher in the observation group compared to the control group,while CD8+,regulatory T cells,and natural killer cells were lower(P<0.05).Additionally,the incidence of leukopenia,nausea,and vomiting was lower in observed group(P<0.05).No significant differences were observed in the incidence of other adverse reactions(P>0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.
基金Special Emergency research and development of Social Benefiting Technology Program,Qingdao,Grant/Award Number:23-7-8-smjk-3-nshProject for Development of TCM Science and Technology of Shandong Province,Grant/Award Number:M-2022145+1 种基金Major Basic Program of Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2021ZD17Jinan City Funding for University Innovation Teams,Grant/Award Number:2021GXRC028。
文摘Background:Qi pi pill(QPP),which contains Renshen,Baizhu,Fuling,Gancao,Chenpi,Shanyao,Lianzi,Shanzha,Liushenqu,Maiya,and Zexie,was recommended for preventing and treating COVID-19 in Shandong Province(China).However,the mechanism by which QPP treats infectious diseases remains unclear.This study aims to investigate the therapeutic effect of QPP in vitro and on acute influenza infection in mice,exploring its mechanism of action against influenza A virus(IAV).Methods:The in vitro activity of QPP was assessed using dose–response curve analysis and titer reduction assay,and its antiviral mechanism was identified in vitro by realtime polymerase chain reaction(PCR),time-of-addition,and enzymatic assays.The antiviral efficacy of QPP was further evaluated in vivo using BALB/c mice infected with IAV.At the same time,each single Chinese herbal medicine in QPP was evaluated to preliminarily identify those with antiviral effects.Results:In vitro results showed that QPP exhibited a higher potency antiviral effect against both influenza A and B viruses,inhibiting viral RNA replication and release by targeting RNA-dependent RNA polymerase and neuraminidase.Additionally,QPP significantly decreased the expression of inflammatory cytokines in A549 cells.In vivo study revealed that QPP significantly reduced the lung index and viral load in lung tissue of mice infected with IAV.Renshen,Gancao,Zexie,and Lianzi were the Chinese herbal medicines from QPP that showed anti-IAV activity.Conclusion:The antiviral activity of QPP targets IAV replication and release,cytokine modulation in host cells,and provides protection in mice with acute influenza infection.
文摘Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January 2025.The author confirmed this article’s proof on 23 January 2025 without any questions.But on 06 July 2025,the editorial team found,there was an error in Figure 8.Specifically,Figure 8E,Figure 8F and Figure 8G were mistakenly duplicated.The authors acknowledge that the original version of Figure 8 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.
基金supported by Special Project of Traditional Chinese Medicine Scientific Research in Henan Province(2023ZY1024,2022ZY1144)Special COVID-19 Research Project of Traditional Chinese Medicine in Henan Province(2022ZYFY08)+1 种基金Traditional Chinese Medicine Culture and Management Research Project in Henan Province(TCM2023005)Basic Scientific Research Business Fund Project of Henan Integrative Medicine Hospital(2304025,2304015)。
文摘Objective To elucidate the mechanism of Fuzheng Gankang Pill in treating combined allergic rhinitis and asthma syndrome(CARAS)with lung-spleen qi deficiency and wind-cold invading the lung syndrome using network pharmacology and molecular docking.MethodsThe active components and targets of the 13 herbs in Fuzheng Gankang Pill were retrieved from the TraditionalChinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)and HERB.A“core herb-active component-target"network was constructed using Cytoscape to screen core components.CARAS disease targets were obtained from Genecards,NationalCenter for Biotechnology Information(NCBI),and Online Mendelian Inheritance in Man(OMIM).Targets related to the clinical phenotypes of CARAS with lung-spleen qi deficiency and wind-cold invading the lung syndrome were retrieved from the Traditional ChineseMedicineSyndrome Ontology and Multidimensional Quantitative Association Calculation Platform.The intersection of CARAS disease targets and syndromerelated targets yielded CARAS disease-syndrome targets.The intersection of Fuzheng Gankang Pill component-related targets and CARAS disease-syndrome targets provided“disease-syndrome-formula”intersection targets.These targets were uploaded to the STRING database for protein-protein interaction(PPI)network analysis,with topological analysis identifying key targets.Metascape was used for Gene Ontology(GO)enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis.Molecular docking validation was performed using AutoDock Vina 1.1.2.Results The 13 core herbs of Fuzheng Gankang Pill contain a total of 200 active ingredients and 289 related targets.There are 2,412 disease targets for CARAS and 735 corresponding disease targets for the main and secondary symptoms of lung-spleen qi deficiency and wind-cold invading the lung.Through the Venn diagram,a total of 35 intersecting targets were obtained for Fuzheng Gankang Pill,CARAS,and the combination of lung-spleen qi deficiency and wind-cold invading the lung syndrome.Quercetin,Polygonatum sibiricum flavonoids,β-sitosterol,baicalein,kaempferol,etc.,are core components.PPI network analysis found that tumor necrosis factor(TNF),prostaglandin-endoperoxide synthase 2(PTGS2),interleukin(IL)-1β,IL-6,transforming growth factor beta 1(TGFβ1),BCL2,etc.,are the core targets for the compound to exert therapeutic effects.GO enrichment analysis showed that the 13 core drugs of Fuzheng Gankang Pill mainly participate in key biological processes such as positive regulation of protein modification,response to hormones,and negative regulation of cell population proliferation through protein kinases in areas such as membrane rafts,membrane microregions,plasma membrane protein complexes,and receptor com-plexes.KEGG enriched a total of 30 signaling pathways.Molecular docking shows that active ingredients such as quercetin and kaempferol bind stably toTNF(binding energy≤-9.0 kcal·mol^(-1))and PTGS2(≤-8.5kcal·mol^(-1)).Conclusion Fuzheng Gankang Pill may regulate biological processes such as cell apoptosis,tissue remodeling,inflammatory response,and immune response by acting on core targets such as TNF and PTGS2 through its core components quercetin,baicalein,β-sitosterol,baicalein,and kaempferol,thereby exerting therapeutic effects on CARAS with lung-spleen qi deficiency and wind-cold invading the lung syndrome.
文摘Objective:To observe the therapeutic effect of Moist Burn Ointment combined with rotating moxibustion on patients with pressure ulcers and deficiency of both Qi and blood.Methods:40 patients with pressure ulcers and deficiency of both Qi and blood were randomly divided into two groups from July 2024 to November 2025.Group A received Moist Burn Ointment combined with rotating moxibustion,while Group B received Moist Burn Ointment only.Results:Group A showed better efficacy,wound healing time,dressing change frequency,satisfaction,PUSH score,and adverse reaction indicators compared to Group B(P<0.05).Conclusion:The combination of Moist Burn Ointment and rotating moxibustion in the treatment of patients with pressure ulcers and deficiency of both Qi and blood can shorten wound healing time,reduce dressing change frequency,and alleviate the degree of pressure ulcers,which is safe and efficient.
基金supported by the National Natural Science Foundation of China(T2341019)NSFC-Guangdong Joint Fund(U1132001)+9 种基金General Program of the National Natural Science Foundation of China(82174243 and 82204948)Natural Science Foundation of Guangdong Province,China(2023A1515110757)Guangzhou Science and Technology Plan Project(2024B03J1343)Major Scientific and Technological Project of Guangzhou Municipal Health Commission(20252D003)Research Project of Traditional Chinese Medicine Bureau of Guangdong Province(20241208)General project of Beijing Natural Science Foundation(7242227)Fundamental Research Funds for the Central Universities(BZY-JMZY-2022-001 and 2023-JYB-JBZD-009)High-level Key Discipline of the National Administration of Traditional Chinese Medicine-Traditional Chinese Constitutional Medicine(zyyzdxk-2023251)Major Science and Technology Special Projects in Hubei Province(2023BCA005)the Chief Scientist Research Project of Hubei Shizhen Laboratory(HSL2024SX0002).
文摘Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.
基金supported by the Project of LI Ruiyu National Famous Traditional Chinese Medicine Expert Inheritance Studio(No.[2022]4 issued by the National Administration of Traditional Chinese Medicine and No.[2024]3 issued by Hebei Administration of Traditional Chinese Medicine)the Seventh Batch of National Academic Experience Inheritance Project for Senior Traditional Chinese Medicine Experts(No.[2022]76 issued by the National Administration of Traditional Chinese Medicinethe Scientific Research Project of Hebei Administration of Traditional Chinese Medicine(No.2025593).
文摘Objectives:To propose a new idea of“lung ventilation and Qi regulation”for preventing and treating lung cancer,and to summarize the corresponding Tongfei Huajie prescription,as a systematic theoretical and practical innovation.Methods:Based on the etiology and pathogenesis of lung cancer,the anatomy,physiology and pathology of the lung,and inspired by the ancient“Tuoyue”(bellows)theory,this study combined the clinical observation of ventilation issues in lung cancer patients.The Tongfei Huajie prescription was formulated following the classic principle of monarch(Jun),minister(Chen),assistant(Zuo),and guide(Shi),and was interpreted with modern pharmacological research.Results:A novel therapeutic concept of“lung ventilation and Qi regulation”was proposed.The corresponding Tongfei Huajie prescription was developed,which has the effects of ventilating the lung,expelling phlegm dampness,tonifying Qi,tonifying the kidney and spleen for lung health,soothing the liver and descending lung Qi,and clearing the heart and moistening the lung.Clinical application has achieved obvious curative effect.Conclusions:This work presents a systematic summary of the innovation in“theory,method,formula and herb”for lung cancer treatment,demonstrating the advantages of Traditional Chinese Medicine in this field.
