reshwater essential for civilization faces risk from untreated effluents discharged by industries,agriculture,urban areas,and other sources.Increasing demand and abstraction of freshwater deteriorate the pollution sce...reshwater essential for civilization faces risk from untreated effluents discharged by industries,agriculture,urban areas,and other sources.Increasing demand and abstraction of freshwater deteriorate the pollution scenario more.Hence,water quality analysis(WQA)is an important task for researchers and policymakers to maintain sustainability and public health.This study aims to gather and discuss the methods used for WQA by the researchers,focusing on their advantages and limitations.Simultaneously,this study compares different WQA methods,discussing their trends and future directions.Publications from the past decade on WQA are reviewed,and insights are explored to aggregate them in particular categories.Three major approaches,namely—water quality indexing,water quality modeling(WQM)and artificial intelligence-based WQM,are recognized.Different methodologies adopted to execute these three approaches are presented in this study,which leads to formulate a comparative discussion.Using statistical operations and soft computing techniques have been done by researchers to combat the subjectivity error in indexing.To achieve better results,WQMs are being modified to incorporate the physical processes influencing water quality more robustly.The utilization of artificial intelligence was primarily restricted to conventional networks,but in the last 5 years,implications of deep learning have increased rapidly and exhibited good results with the hybridization of feature extracting and time series modeling.Overall,this study is a valuable resource for researchers dedicated to WQA.展开更多
The high labor demand during rice seedling cultivation and transplantation poses a significant challenge in advancing machine-transplanted rice cultivation.This problem may be solved by increasing the seeding rate dur...The high labor demand during rice seedling cultivation and transplantation poses a significant challenge in advancing machine-transplanted rice cultivation.This problem may be solved by increasing the seeding rate during seedling production while reducing the number of seedling trays.This study conducted field experiments from 2021 to 2022,using transplanting seedling ages of 10 and 15 days to explore the effects of 250,300,and 350 g/tray on the seedling quality,mechanical transplantation quality,yields,and economic benefits of rice.The commonly used combination of 150 g/tray with a 20-day seedling age in rice production was used as CK.The cultivation of seedlings under a high seeding rate and short seedling age significantly affected seedling characteristics,but there was no significant difference in seedling vitality compared to CK.The minimum number of rice trays used in the experiment was observed in the treatment of 350-10(300 g/tray and 10-day seedling age),only 152-155 trays ha^(-1),resulting in a 62%reduction in the number of trays needed.By increasing the seeding rate of rice,missed holes during mechanical transplantation decreased by 2.8 to 4%.The treatment of 300-15(300 g/tray and 15-day seedling age)achieved the highest yields and economic gains.These results indicated that using crop straw boards can reduce the application of seedling trays.On that basis,rice yields can be increased by raising the seeding rate and shortening the seedling age of rice without compromising seedling quality.展开更多
Evidence is not homogeneous on indicators able to monitor and assess qualityperformance for organ donation. This may be related to differences in healthcareorganizations among countries but also to the scarcity of dat...Evidence is not homogeneous on indicators able to monitor and assess qualityperformance for organ donation. This may be related to differences in healthcareorganizations among countries but also to the scarcity of data on this topic so far.In the present review, we assessed available evidence on quality metrics in solidorgan procurement in the United States and in Europe by means of a PubMedsearch. Evidence was summarized according to countries, considering that thedonation and transplantation systems differ from country to country. In UnitedStates, the assessment of these indicators is periodically performed by the nationalnetwork for organ sharing to evaluate the performance of each Organ ProcurementOrganization (OPO). Quality metrics consider several factors, in primispopulation characteristics (i.e. race/ethnicity, age, socio-economic status). That iswhy the assessment of each OPO performance relies on several quality metrics,not only one single indicator. In Europe, quality improvement programs representa structural element of organ and transplant system in several countries, but fewpapers have to date addressed the results obtained by a quality improvementprogram based on indicators. In Poland, the use of quality indicators and improvementprocedures were associated with better results in those hospitals whichimplemented these programs in respect to hospitals who did not. In TuscanyRegion (Italy) the implementation of a monitoring and reporting approach basedon indicators by the Regional Transplant Center was associated with an increasedin transplant and donation activity (especially in cDCD donors). According toavailable evidence, the development of a method for quality assessment andquality improvement has been recognized as pivotal for donation and transplantauthorities to identify key interventions either at national and/or hospital levels.展开更多
Objective:The objective of this study is to investigate the effect of empowerment strategies on quality of life(QOL),sleep quality,level of perceived stress,and activity of daily living(ADL)among perimenopausal women....Objective:The objective of this study is to investigate the effect of empowerment strategies on quality of life(QOL),sleep quality,level of perceived stress,and activity of daily living(ADL)among perimenopausal women.Materials and Methods:A single-blinded randomized,controlled community trial was adapted.The sample consisted of 70(35 in each group)perimenopausal women in Tapoban community,Bhubaneswar.A purposive sampling technique was used.Tools used were structured sociodemographic questions,the Menopause-Specific Quality of Life Questionnaire tool,ADL scale,the Pittsburgh Sleep Quality Index(PSQI)scale,and the Perceived Stress scale.The perimenopausal empowerment strategy was introduced to the intervention arm,and the control arm received standard care provided by the government.Descriptive statistics and analytical statistics(paired t-test,Chi-square)were employed to compare groups and examine relationships.Statistical analysis was likely conducted using SPSS version 21 software.The significance level was set at<0.05.Results:The study found a significant improvement in the QOL among perimenopausal women in the experimental group after intervention(t=16.764,P<0.00001).However,there were no significant differences between the experimental and control groups in terms of IADL scores(P=0.323)and PSQI scores(P=0.323)after intervention.The control group had significantly higher perceived stress scores compared to the experimental group(P=0.003).Age and employment status showed significant association with sociodemographic factors associated with QOL.Working women had a poorer QOL compared to homemakers,which was statistically significant(P=0.023).Conclusion:Empowerment strategies,such as training on improving sleep patterns,QOL,self-care activities and reducing perceived stress,were found to be effective interventions for perimenopausal women.展开更多
Objective To develop a quality appraisal tool for case reports in traditional Chinese medicine(TCM)based on their characteristics.Methods An extensive literature search was conducted in Chinese Biomedical Literature D...Objective To develop a quality appraisal tool for case reports in traditional Chinese medicine(TCM)based on their characteristics.Methods An extensive literature search was conducted in Chinese Biomedical Literature Database(CBM),China National Knowledge Infrastructure(CNKI),and China Science and Technology Journal Database(CSTJ),focusing on expert consensus statements and check-lists for TCM case reports.Relevant items were extracted,and a Delphi method involving 34 experts was used in two rounds to rate each item on a 5-point Likert scale.Items were screened based on measures of central tendency and coordination(including total score,mean score,percentage of items rated as unimportant,and coefficient of variation).The weighted average method was used to determine item weights and construct the appraisal tool.Internal consistency was assessed using Cronbach’sαcoefficient.The finalized tool was pilot-tested by two reviewers independently appraising 20 case reports,with an additional four reviewers evaluating 5 of these cases to compare inter-rater consistency.Results A total of 9513 articles were retrieved,and 96 items from 25 articles were extracted.After two rounds of the Delphi method,27 items across 10 domains were retained.The Cron-bach’sαcoefficient was 0.72 in the first round(acceptable range),and 0.96 in the second round,indicating strong internal consistency.The tool was piloted by six reviewers,achieving a kappa value of 0.663 and a Kendall’s coefficient of concordance of 0.845,demonstrating high consistency among reviewers.Conclusion The developed TCM case report quality appraisal tool,consisting of 27 items in 10 domains,offers a scientific and reliable means of assessing the quality of TCM case reports.The tool showed high consistency and practical utility,and its application is expected to en-hance the standardization,scientific rigor,and evidence quality of TCM case reports,facilitat-ing the integration of traditional medical knowledge with modern evidence-based standards.展开更多
Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the...Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the transformation of the energy sector.Based on the achievements of high-quality energy cooperation within the Belt and Road Initiative,this paper systematically analyzes the current state of energy cooperation under the Belt and Road Initiative.In accordance with the intrinsic requirements for high-quality energy cooperation,and building upon the analysis and summary of prior research,this paper proposes strategies to promote high-quality energy cooperation within the Belt and Road Initiative:(1)Innovating cooperative concepts and optimizing the cooperative environment;(2)Innovating cooperation modes and expanding the scope of cooperation;(3)Improving the cooperation mechanism and building a multi-level cooperation platform;(4)Strengthening cultural exchanges and promoting dialogue.This paper offers insights and support for fostering high-quality collaboration within the Belt and Road Initiative and enhancing international energy cooperation.展开更多
Objective:Investigating the Mediating Role of Pain in the Relationship Between Sleep Quality and Health-Related Quality of Life Among Elderly Patients with Chronic Diseases.Methods:Using data from the 2018 China Healt...Objective:Investigating the Mediating Role of Pain in the Relationship Between Sleep Quality and Health-Related Quality of Life Among Elderly Patients with Chronic Diseases.Methods:Using data from the 2018 China Health and Retirement Longitudinal Study(CHARLS),this study included 3,284 participants aged 60 years or older with chronic diseases.The sleep quality,pain status,health-related quality of life,and demographic-related data of these elderly patients were obtained.Pearson correlation analysis was conducted to assess the bivariate relationships among the variables.The mediating role of pain in the sleep quality-HRQoL relationship was tested using linear regression models,complemented by bootstrap sampling to verify the indirect effect.Results:Sleep quality was positively associated with health-related quality of life(r=0.218,p<0.001).Conversely,pain demonstrated significant negative correlations with both sleep quality(r=-0.496,p<0.001)and health-related quality of life(r=-0.067,p<0.001).The mediating effect results showed that pain played a partial mediating role between sleep quality and health-related quality of life in elderly patients with chronic diseases(effect value=0.049),and the mediating effect accounted for 23.33%.Conclusion:Pain is a mediating variable between sleep quality and health-related quality of life in elderly patients with chronic diseases.This suggests that clinical practice should incorporate pain assessment into standard clinical care of elderly patients with sleep disorders and chronic diseases.By alleviating pain,sleep quality can be improved,and subsequently,their health-related quality of life can be enhanced.展开更多
Coastal areas face challenges in updating and enhancing the quality of coastal shelterbelt forests due to limited soil resource utilization,the biological characteristics of tree species,and the impact of coastal stor...Coastal areas face challenges in updating and enhancing the quality of coastal shelterbelt forests due to limited soil resource utilization,the biological characteristics of tree species,and the impact of coastal storm surges.This study,based on clarifying the connotation of stand quality(SQ)for Casuarina equisetifolia(C.equisetifolia),a typical coastal shelterbelt species,integrates stand growth conditions and structure,applying the AHP-EWM method to construct an SQ evaluation model.The model identifies key factors influencing the quality of C.equisetifolia stands and explores the mechanisms driving their growth processes.The results indicate that mean tree height,mean diameter at breast height,and stand density are key indicators for assessing the SQ of C.equisetifolia stands.The SQ of C.equisetifolia coastal shelterbelt stands varies across different land-sea positions,mainly influenced by stand age and soil nutrient levels.As stand age increases,the SQ initially improves and then declines.Additionally,C.equisetifolia trees growing in nutrient-rich soils exhibit better growth and higher SQ than those in poor soils.The findings of this study provide a theoretical foundation for the management and quality enhancement of coastal shelterbelt forests.展开更多
This study examined the impact of teacher-student relationship quality on students’risk of bullying victimiza-tion and the mediating roles of student-student relationships and student engagement in this relationship....This study examined the impact of teacher-student relationship quality on students’risk of bullying victimiza-tion and the mediating roles of student-student relationships and student engagement in this relationship.A total of 656 Chinese junior high school students(females=361,mean age=13.75,SD=0.98)completed validated measures of teacher-student relationship quality,student-student relationship quality,student engagement,and bullying victimization.Regression analysis results indicated that higher teacher-student relationship quality predicted a lower risk of student bullying victimization.Serial mediating effect testing of the student-student relationship quality and student engagement revealed that these factors fully mediated the relationship between teacher-student relationship quality and bullying victimization,resulting in a lower risk of bullying victimization.The results showed that student-student relationship quality had a more substantial mediating effect than student engagement.Thefindings support the Socio-Ecological Framework,suggesting that within the Microsystem,interactions between individuals and their immediate environments significantly impact their behavior.Specifically,thesefindings suggest that good teacher-student relationships can enhance the quality of student-student relationships and student engagement,thereby preventing and reducing the occurrence of bullying victimization.展开更多
Objective:To investigate the effectiveness of quality management models in enhancing service quality at physical examination centers.Methods:A total of 1,200 examinees who received services at our hospital’s physical...Objective:To investigate the effectiveness of quality management models in enhancing service quality at physical examination centers.Methods:A total of 1,200 examinees who received services at our hospital’s physical examination center between January 2022 and June 2023 were randomly divided into a control group(600 cases)and an observation group(600 cases).The two groups were compared in terms of examination process duration,report quality scores,detection rate of abnormal findings,overall patient satisfaction,and staff job satisfaction.Results:The observation group showed significantly shorter examination time(98.5±15.2 minutes vs 156.3±22.7 minutes,P<0.01),higher report quality scores(92.4±3.5 vs 78.6±6.8 points,P<0.01),improved detection rate of abnormalities(38.7%vs 29.5%,P<0.05),increased patient satisfaction(97.2%vs 82.3%,P<0.01),and greater staff job satisfaction(90.5%vs 72.3%,P<0.01).Conclusion:Quality management models can significantly enhance service quality and operational efficiency at physical examination centers,improve examination outcomes and patient satisfaction,demonstrating substantial clinical application value.展开更多
Objective:To evaluate the effectiveness of quality nursing in the management of reusable instruments in the Central Sterile Supply Department(CSSD).Methods:Eleven nurses from the CSSD department were selected from Jan...Objective:To evaluate the effectiveness of quality nursing in the management of reusable instruments in the Central Sterile Supply Department(CSSD).Methods:Eleven nurses from the CSSD department were selected from January to October 2024,and quality nursing activities were implemented in the management of reusable instruments.The completion of quality indicators was analyzed.The instrument quality management scores,department satisfaction,and nurses’professional ability scores before and after nursing management were compared.Results:After nursing intervention,the qualified rates of initial cleaning and final cleaning of sterilization instruments were 99.66%and 100%,respectively.The qualified rate of packaging was 99.97%,the wet package rate was 0.1‰,the loading qualified rate was 99.88%,and the qualified rate of distribution was 99.99%.After nursing intervention,the nurses’instrument quality management scores,department satisfaction,and nurses’professional ability scores were all higher than those before nursing intervention(P<0.05).Conclusion:Quality nursing activities can improve the cleaning,packaging,and sterilization qualified rates of reusable instruments in the CSSD,enhance the effect of instrument quality management,obtain higher department satisfaction from nurses,cultivate their professional abilities,and possess significant nursing management advantages.展开更多
Water resources are vital for all living beings and should be managed properly to ensure the safety and well-being of humankind.Surface water bodies are constantly faced with serious contamination risks generated prim...Water resources are vital for all living beings and should be managed properly to ensure the safety and well-being of humankind.Surface water bodies are constantly faced with serious contamination risks generated primarily by human activities and urbanization.The problem of waste littering and dumping in developing countries like Nigeria is increasingly affecting environmental resources such as air and water.Several studies have revealed alarming levels of heavy metals that exceed the World Health Organization(WHO)standards.Plastic waste represents a substantial portion of litter,affecting water quality.Pollution results in the depletion of aquatic ecosystems and an increase in water-related diseases.This review aims to assess the impact of waste littering and dumping on surface water quality in Nigeria.In this review,the findings of various studies on surface water bodies in Nigeria,particularly those under the influence of urbanization and waste disposal,were compiled.This review compared numerous physical and chemical parameters like pH,dissolved oxygen,and heavy metals,and microbiological properties such as total coliforms.The water quality index(WQI)was also computed in these studies to ascertain the suitability of the water samples for human consumption.Review results showed that numerous water bodies in Nigeria have significantly diverse water quality levels,with some samples meeting or exceeding the WHO guidelines for microbiological,chemical,and physical characteristics.Notably,levels of heavy metals,turbidity,and pH frequently exceeded permissible limits,pointing to contamination from agricultural and industrial sources.The WQI results for multiple locations revealed that the majority of surface water sources were classified as“bad”to“very bad”,meaning they were unfit for human consumption.The results emphasized the critical need for immediate action to prevent further harm and deterioration of surface water bodies in Nigeria.Recommendations include strengthening waste management policies,promoting recycling initiatives,fostering collaborations among stakeholders,developing littering penalties and enforcing fines to curb the challenge,and raising educational awareness from the primary level.This review emphasizes the need for proactive measures to protect the environment and surface water quality in Nigeria.展开更多
Evaluating soil quality(SQ)is crucial for ensuring the long-term stability of restored slope ecosystems,yet selecting efficient assessment methods remains challenging.The aim of this study was to develop a targeted SQ...Evaluating soil quality(SQ)is crucial for ensuring the long-term stability of restored slope ecosystems,yet selecting efficient assessment methods remains challenging.The aim of this study was to develop a targeted SQ evaluation system to compare the differences in the effectiveness of ecological restoration methods for slopes.We analysed the characteristics of 18 soil physicochemical and biological indices within a total data set(TDS)for five restored slopes with distinct ecological restoration techniques and three untreated slopes(as the control)in Yichang,China.Principal component analysis,entropy weight method,and Norm were employed to identify a minimum data set(MDS)and four soil quality index(SQI)models,linear unweighted(SQI_(L-A)),linear weighted(SQI_(L-W)),nonlinear unweighted(SQI_(NL-A)),and nonlinear weighted(SQI_(NL-W)),were used to comprehensively evaluate the MDS-based SQ.The results revealed that(1)MDS,consisting of microbial biomass carbon(MBC),microbial biomass phosphorus(MBP),microbial biomass quotient(qMBC),catalase(CAT),and bulk density(BD),effectively characterized the SQ of the ecological restoration slopes;(2)the SQI_(NL-W)model demonstrated superior discrimination among different ecological restoration slopes,with a significantly greater coefficient of determination(R^(2)=0.881,P<0.01)than other SQI models;and(3)all five ecological restoration techniques effectively improved SQ of slope to varying degrees,elevating it from low to high levels,with the vegetative cement-soil eco-restoration&vegetation concrete eco-restoration technique demonstrating the best effect(SQI_(NL-W)=0.627).Our study developed a practical SQ evaluation system based on the validated MDS and the most suitable SQI model(SQI_(NL-W)).This system enables reliable assessment on the effectiveness of restoration techniques.展开更多
This study explores whether the current external quality assessment(EQA)level and acceptable bias for basic semen analysis in China are clinically useful.We collected data of semen EQA from Andrology laboratories in t...This study explores whether the current external quality assessment(EQA)level and acceptable bias for basic semen analysis in China are clinically useful.We collected data of semen EQA from Andrology laboratories in the Hunan Province(China)in 2022 and searched for data in the published literature from January2000 to December 2023 in China.On the basis of these data,we analyzed the coefficients of variation and acceptable biases of different quality control materials for basic semen analysis through robust statistics.We compared these findings with quality specifications based on biological variation from optimal,desirable,and minimum levels of bias to seek a unified and more suitable semen EQAbias evaluation standard for China's national conditions.Different sources of semen quality control material exhibited considerable variation in acceptable biases among laboratories,ranging from 8.2%to 56.9%.A total of 50.0% of the laboratories met the minimum quality specifications for progressive motility(PR),whereas 100.0%and 75.0%of laboratories met only the minimum quality specifications for sperm concentration and total motility(nonprogressive[NP]+PR),respectively.The Z value for sperm concentration and PR+NP was equivalent to the desirable performance specification,whereas the Z value for PR was equivalent only to the minimum performance specification.This study highlights the feasibility of operating external quality assessment schemes for basic semen analysis using quality specifications based on biological variation.These specifications should be unified among external quality control(EQC)centers based on biological variation.展开更多
Knee osteoarthritis(KOA),characterized by heterogeneous arthritic manifestations and complex peripheral joint disorder,is one of the leading causes of disability worldwide,which has become a high burden due to the mul...Knee osteoarthritis(KOA),characterized by heterogeneous arthritic manifestations and complex peripheral joint disorder,is one of the leading causes of disability worldwide,which has become a high burden due to the multifactorial nature and the deficiency of available disease-modifying treatments.The application of mesenchymal stem/stromal cells(MSCs)as therapeutic drugs has provided novel treatment options for diverse degenerative and chronic diseases including KOA.However,the complexity and specificity of the“live”cells have posed challenges for MSC-based drug development and the concomitant scale-up preparation from laboratory to industrialization.For instance,despite the considerable progress in ex vivo cell culture technology for fulfilling the robust development of drug conversion and clinical trials,yet significant challenges remain in obtaining regulatory approvals.Thus,there’s an urgent need for the research and development of MSC drugs for KOA.In this review,we provide alternative solution strategies for the preparation of MSC drugs on the basis of the principle of quality by design,including designing the cell production processes,quality control,and clinical applications.In detail,we mainly focus on the quality by design method for MSC manufacturing in standard cell-culturing factories for the treatment of KOA by using the Quality Target Product Profile as a starting point to determine potential critical quality attributes and to establish relationships between critical material attributes and critical process parameters.Collectively,this review aims to meet product performance and robust process design,and should help to reduce the gap between compliant products and the production of compliant good manufacturing practice.展开更多
The evaluation of rock mass quality and its mechanical properties is crucial for tunnel construction.The basic quality(BQ)method is the national standard for rock mass classification in China,with the BQ value determi...The evaluation of rock mass quality and its mechanical properties is crucial for tunnel construction.The basic quality(BQ)method is the national standard for rock mass classification in China,with the BQ value determined by the uniaxial compressive strength(UCS)and the integrity index(Kv).However,traditional rock mechanics testing methods have inherent limitations,which complicate the rapid evaluation of rock mass quality at tunnel sites.Digital drilling process monitoring(DPM)offers a novel approach for evaluating rock mass quality and its mechanical properties.A hydraulic rotary drilling rig,equipped with the DPM system,was used to conduct digital drilling tests at the tunnel face.The DPM data for the net drilling process and each sub-process were then analyzed.The correlations between DPM parameter indices and rock mechanical parameters were investigated.Finally,the rock mass quality and its mechanical properties along three boreholes were evaluated.The results indicate that drilling speed in the linear zone(V_(DPM))is quantitatively correlated with rock UCS.Higher UCS values of the drilled rocks correspond to lower V_(DPM) values of the drilling rig.The variability in specific energy is associated with structural disturbances within the rock mass.There is an approximately linear relationship between the standard deviation of normalized specific energy and rock mass K_(v) across the three boreholes.The rock mass quality along drilling depth generally ranges from good(Ⅰ-Ⅱ)to poor(Ⅲ-Ⅴ).This digitalization method provides more detailed information for tunnel stability analysis and design optimization than geological survey data.展开更多
BACKGROUND Although transarterial chemoembolization(TACE)is an effective treatment for liver cancer,clinical practice has shown that many patients experience significant psychological distress following the procedure,...BACKGROUND Although transarterial chemoembolization(TACE)is an effective treatment for liver cancer,clinical practice has shown that many patients experience significant psychological distress following the procedure,which can hinder postoperative recovery and prognosis.Therefore,effective and evidence-based interventions are urgently needed to address this issue.AIM To evaluate the impact of nursing quality-sensitive indicators combined with mindfulness-based stress reduction(MBSR)interventions in patients undergoing TACE.METHODS A total of 84 patients who underwent TACE from June 2022 to March 2024 were enrolled in the study.They were randomly assigned to either the observation group(n=42),which received nursing quality-sensitive indicator-based care combined with MBSR intervention,or the control group(n=42),which received routine care combined with MBSR intervention.Psychological stress response levels[assessed using the Trait Meta-Mood Scale(TMMS)],coping strategies[measured with the Jalowiec Coping Scale(JCS)],quality of care[evaluated using the Perceived Nursing Service Quality(PNSQ)scale],and overall patient satisfaction were compared between the two groups.RESULTS After 4 weeks,the observation group demonstrated significantly higher TMMS scores,as well as increased optimism,support-seeking,bravery,PNSQ scores,and satisfaction(P<0.05).In contrast,scores for selfdependence,conservatism,resignation,and avoidance in the JCS were significantly lower in the observation group than in the control group(P<0.05).CONCLUSION The combination of nursing quality-sensitive indicators and MBSR intervention in TACE patients not only reduces psychological stress and encourages a more positive attitude toward illness but also enhances nursing quality and improves the overall patient experience.展开更多
Water quality is a pressing issue affecting the sustainable development of lakes.To elucidate the spatial and temporal characteristics of water quality in Bos ten Lake,China,this study constructed a comprehensive wate...Water quality is a pressing issue affecting the sustainable development of lakes.To elucidate the spatial and temporal characteristics of water quality in Bos ten Lake,China,this study constructed a comprehensive water quality index(CWQI) based on key water quality indicators,utilizing water quality data collected from 17 sampling sites spaning from 2011 to 2019.Key water quality indicators were determined using factor analysis,and the spatial and temporal characteristics of key water quality indicators and the CWQI were examined using multivariate statistical analysis.The key water quality indicators included pH,chemical oxygen demand(COD),water transparency(SD),NO3-,total dissolved solids(TDS),Cl-,SO42-,and electrical conductivity(EC).Furthermore,the contribution rates of all water quality indicators to the water quality were quantitatively elucidated using the SHapley Additive explanations(SHAP) values,thereby validating the factor analysis outcomes.Among the eight key water quality indicators,the COD had the most significant influence on the water quality of Bos ten Lake.The water quality condition of Bosten Lake has remained at Class Ⅲ from 2011 to 2019(CWQI ranging from3.19 to 3.90).The water quality of Bos ten Lake was characterized by distinct regional differences that arose from hydrodynamic processes within the lake and upstream water quality.The southwestern region exhibited the best water quality(mean CWQI of 3.47),whereas the northwestern region exhibited the worst(mean CWQI of 3.58).It is crucial to acknowledge that alongside the increase in industrial and agricultural effluent discharge monitoring,a series of ecological restoration projects for the lake basin have been initiated.Over time,the water quality of Bosten Lake showed gradual improvement(improvement rate of CWQI at 0.05/a).This study provides a critical scientific basis for enhancing the understanding and effective management of water quality in the Bosten Lake Basin through a comprehensive analysis of its spatial and temporal evolution and driving mechanisms.展开更多
Driven by technological innovation and the innovative allocation of production factors,new quality productive forces(NQPFs)are a key breakthrough and core element propelling China’s transition from a major agricultur...Driven by technological innovation and the innovative allocation of production factors,new quality productive forces(NQPFs)are a key breakthrough and core element propelling China’s transition from a major agricultural country to an advanced agricultural nation.At its core,agricultural modernization represents a frontier shift in agricultural development-a dynamic evolution of productive forces across technological forms,farmer demographics,industrial structures,and urban-rural relations.NQPFs drive the high-quality,integrated development of agricultural modernization through agricultural technological innovation,green and low-carbon practices,and the enhancement of all production factors.As NQPFs evolve and agricultural modernization advances,we must address constraints stemming from gaps in technology,models,resources,and talent.Furthermore,we must foster deep integration among industry,research,and education to develop new pathways for industrial upgrading,promote green and efficient agricultural development,and bridge existing technological gaps.These collective efforts are crucial for accelerating the high-quality development of agricultural modernization.展开更多
Objective:To explore the effects of high-quality nursing intervention on negative emotions and quality of life in gynecological patients after laparoscopy.Methods:A total of 132 gynecological patients after laparoscop...Objective:To explore the effects of high-quality nursing intervention on negative emotions and quality of life in gynecological patients after laparoscopy.Methods:A total of 132 gynecological patients after laparoscopy were randomly divided into an observation group(n=66)and a control group(n=66)in a prospective study.The con-trol group received routine nursing care,while the observation group received high-quality nursing intervention.Anxiety,depression,quality of life,postoperative pain,self-care ability,and patient satisfaction were compared between the two groups.Results:The Self-Rating Anxiety Scale and Self-Rating Depression Scale scores were sig-nificantly lower in the observation group compared to the control group(both P<0.001).Pain scores at 6,24,48,and 72 hours post-surgery were also lower in the observation group(all P<0.001).The observation group showed significantly higher scores in physical function,general health,social function,emotional role,and mental health(all P<0.001).Furthermore,the observation group demonstrated better self-care skills,self-concept,self-care responsibility,and health knowledge(all P<0.001).Nursing satisfaction during hospitalization was significantly higher in the observation group than in the control group(P<0.05).Conclusion:High-quality nursing intervention is effective in improving depression,anxiety,postoperative pain,and quality of life in gynecological patients after laparoscopy.It also enhances self-care ability and patient satisfaction,making it worthy of clinical promotion and application.展开更多
基金State University Research Excellence(SURE),SERB,GOI,Grant/Award Number:SUR/2022/001557。
文摘reshwater essential for civilization faces risk from untreated effluents discharged by industries,agriculture,urban areas,and other sources.Increasing demand and abstraction of freshwater deteriorate the pollution scenario more.Hence,water quality analysis(WQA)is an important task for researchers and policymakers to maintain sustainability and public health.This study aims to gather and discuss the methods used for WQA by the researchers,focusing on their advantages and limitations.Simultaneously,this study compares different WQA methods,discussing their trends and future directions.Publications from the past decade on WQA are reviewed,and insights are explored to aggregate them in particular categories.Three major approaches,namely—water quality indexing,water quality modeling(WQM)and artificial intelligence-based WQM,are recognized.Different methodologies adopted to execute these three approaches are presented in this study,which leads to formulate a comparative discussion.Using statistical operations and soft computing techniques have been done by researchers to combat the subjectivity error in indexing.To achieve better results,WQMs are being modified to incorporate the physical processes influencing water quality more robustly.The utilization of artificial intelligence was primarily restricted to conventional networks,but in the last 5 years,implications of deep learning have increased rapidly and exhibited good results with the hybridization of feature extracting and time series modeling.Overall,this study is a valuable resource for researchers dedicated to WQA.
基金funded by the Jiangsu Key Research Program,China(BE2022338)the Jiangsu Agricultural Science and Technology Innovation Fund,China(CX(23)3107)+3 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions,China(22KJB210004)the Jiangsu Province Agricultural Major Technology Collaborative Promotion Project,China(2022-ZYXT-04-1)the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(KYCX23_3569)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China.
文摘The high labor demand during rice seedling cultivation and transplantation poses a significant challenge in advancing machine-transplanted rice cultivation.This problem may be solved by increasing the seeding rate during seedling production while reducing the number of seedling trays.This study conducted field experiments from 2021 to 2022,using transplanting seedling ages of 10 and 15 days to explore the effects of 250,300,and 350 g/tray on the seedling quality,mechanical transplantation quality,yields,and economic benefits of rice.The commonly used combination of 150 g/tray with a 20-day seedling age in rice production was used as CK.The cultivation of seedlings under a high seeding rate and short seedling age significantly affected seedling characteristics,but there was no significant difference in seedling vitality compared to CK.The minimum number of rice trays used in the experiment was observed in the treatment of 350-10(300 g/tray and 10-day seedling age),only 152-155 trays ha^(-1),resulting in a 62%reduction in the number of trays needed.By increasing the seeding rate of rice,missed holes during mechanical transplantation decreased by 2.8 to 4%.The treatment of 300-15(300 g/tray and 15-day seedling age)achieved the highest yields and economic gains.These results indicated that using crop straw boards can reduce the application of seedling trays.On that basis,rice yields can be increased by raising the seeding rate and shortening the seedling age of rice without compromising seedling quality.
文摘Evidence is not homogeneous on indicators able to monitor and assess qualityperformance for organ donation. This may be related to differences in healthcareorganizations among countries but also to the scarcity of data on this topic so far.In the present review, we assessed available evidence on quality metrics in solidorgan procurement in the United States and in Europe by means of a PubMedsearch. Evidence was summarized according to countries, considering that thedonation and transplantation systems differ from country to country. In UnitedStates, the assessment of these indicators is periodically performed by the nationalnetwork for organ sharing to evaluate the performance of each Organ ProcurementOrganization (OPO). Quality metrics consider several factors, in primispopulation characteristics (i.e. race/ethnicity, age, socio-economic status). That iswhy the assessment of each OPO performance relies on several quality metrics,not only one single indicator. In Europe, quality improvement programs representa structural element of organ and transplant system in several countries, but fewpapers have to date addressed the results obtained by a quality improvementprogram based on indicators. In Poland, the use of quality indicators and improvementprocedures were associated with better results in those hospitals whichimplemented these programs in respect to hospitals who did not. In TuscanyRegion (Italy) the implementation of a monitoring and reporting approach basedon indicators by the Regional Transplant Center was associated with an increasedin transplant and donation activity (especially in cDCD donors). According toavailable evidence, the development of a method for quality assessment andquality improvement has been recognized as pivotal for donation and transplantauthorities to identify key interventions either at national and/or hospital levels.
文摘Objective:The objective of this study is to investigate the effect of empowerment strategies on quality of life(QOL),sleep quality,level of perceived stress,and activity of daily living(ADL)among perimenopausal women.Materials and Methods:A single-blinded randomized,controlled community trial was adapted.The sample consisted of 70(35 in each group)perimenopausal women in Tapoban community,Bhubaneswar.A purposive sampling technique was used.Tools used were structured sociodemographic questions,the Menopause-Specific Quality of Life Questionnaire tool,ADL scale,the Pittsburgh Sleep Quality Index(PSQI)scale,and the Perceived Stress scale.The perimenopausal empowerment strategy was introduced to the intervention arm,and the control arm received standard care provided by the government.Descriptive statistics and analytical statistics(paired t-test,Chi-square)were employed to compare groups and examine relationships.Statistical analysis was likely conducted using SPSS version 21 software.The significance level was set at<0.05.Results:The study found a significant improvement in the QOL among perimenopausal women in the experimental group after intervention(t=16.764,P<0.00001).However,there were no significant differences between the experimental and control groups in terms of IADL scores(P=0.323)and PSQI scores(P=0.323)after intervention.The control group had significantly higher perceived stress scores compared to the experimental group(P=0.003).Age and employment status showed significant association with sociodemographic factors associated with QOL.Working women had a poorer QOL compared to homemakers,which was statistically significant(P=0.023).Conclusion:Empowerment strategies,such as training on improving sleep patterns,QOL,self-care activities and reducing perceived stress,were found to be effective interventions for perimenopausal women.
基金General Program of National Natural Science Foundation of China (82274412)Natural Science Foundation of Hunan Province (2020JJ4062)Science and Technology Innovation Program of Hunan Province (2020RC2061)。
文摘Objective To develop a quality appraisal tool for case reports in traditional Chinese medicine(TCM)based on their characteristics.Methods An extensive literature search was conducted in Chinese Biomedical Literature Database(CBM),China National Knowledge Infrastructure(CNKI),and China Science and Technology Journal Database(CSTJ),focusing on expert consensus statements and check-lists for TCM case reports.Relevant items were extracted,and a Delphi method involving 34 experts was used in two rounds to rate each item on a 5-point Likert scale.Items were screened based on measures of central tendency and coordination(including total score,mean score,percentage of items rated as unimportant,and coefficient of variation).The weighted average method was used to determine item weights and construct the appraisal tool.Internal consistency was assessed using Cronbach’sαcoefficient.The finalized tool was pilot-tested by two reviewers independently appraising 20 case reports,with an additional four reviewers evaluating 5 of these cases to compare inter-rater consistency.Results A total of 9513 articles were retrieved,and 96 items from 25 articles were extracted.After two rounds of the Delphi method,27 items across 10 domains were retained.The Cron-bach’sαcoefficient was 0.72 in the first round(acceptable range),and 0.96 in the second round,indicating strong internal consistency.The tool was piloted by six reviewers,achieving a kappa value of 0.663 and a Kendall’s coefficient of concordance of 0.845,demonstrating high consistency among reviewers.Conclusion The developed TCM case report quality appraisal tool,consisting of 27 items in 10 domains,offers a scientific and reliable means of assessing the quality of TCM case reports.The tool showed high consistency and practical utility,and its application is expected to en-hance the standardization,scientific rigor,and evidence quality of TCM case reports,facilitat-ing the integration of traditional medical knowledge with modern evidence-based standards.
基金National Social Science Fund Western Project,“Promoting strategies and realization paths for high-quality energy cooperation under the Belt and Road Initiative”(Grant No.24XGJ002)。
文摘Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the transformation of the energy sector.Based on the achievements of high-quality energy cooperation within the Belt and Road Initiative,this paper systematically analyzes the current state of energy cooperation under the Belt and Road Initiative.In accordance with the intrinsic requirements for high-quality energy cooperation,and building upon the analysis and summary of prior research,this paper proposes strategies to promote high-quality energy cooperation within the Belt and Road Initiative:(1)Innovating cooperative concepts and optimizing the cooperative environment;(2)Innovating cooperation modes and expanding the scope of cooperation;(3)Improving the cooperation mechanism and building a multi-level cooperation platform;(4)Strengthening cultural exchanges and promoting dialogue.This paper offers insights and support for fostering high-quality collaboration within the Belt and Road Initiative and enhancing international energy cooperation.
基金Henan Provincial Government-funded Excellent Clinical Medicine Talent Training Project(Project No.:ZF2024006)Hebei Province Medical Science Research Project Plan(Project No.:20240083)。
文摘Objective:Investigating the Mediating Role of Pain in the Relationship Between Sleep Quality and Health-Related Quality of Life Among Elderly Patients with Chronic Diseases.Methods:Using data from the 2018 China Health and Retirement Longitudinal Study(CHARLS),this study included 3,284 participants aged 60 years or older with chronic diseases.The sleep quality,pain status,health-related quality of life,and demographic-related data of these elderly patients were obtained.Pearson correlation analysis was conducted to assess the bivariate relationships among the variables.The mediating role of pain in the sleep quality-HRQoL relationship was tested using linear regression models,complemented by bootstrap sampling to verify the indirect effect.Results:Sleep quality was positively associated with health-related quality of life(r=0.218,p<0.001).Conversely,pain demonstrated significant negative correlations with both sleep quality(r=-0.496,p<0.001)and health-related quality of life(r=-0.067,p<0.001).The mediating effect results showed that pain played a partial mediating role between sleep quality and health-related quality of life in elderly patients with chronic diseases(effect value=0.049),and the mediating effect accounted for 23.33%.Conclusion:Pain is a mediating variable between sleep quality and health-related quality of life in elderly patients with chronic diseases.This suggests that clinical practice should incorporate pain assessment into standard clinical care of elderly patients with sleep disorders and chronic diseases.By alleviating pain,sleep quality can be improved,and subsequently,their health-related quality of life can be enhanced.
基金supported by the Fujian Forestry Science and Technology Research Project(2023FKJ15)Fuzhou Forestry Science and Technology Research Project(2130206)+1 种基金Special Fund Project for Scientific and Technological Innovation of Fujian Agriculture and Forestry University(KFB23173)University Key Lab for Geomatics Technology&Optimize Resources Utilization in Fujian Province(KJG20104A).
文摘Coastal areas face challenges in updating and enhancing the quality of coastal shelterbelt forests due to limited soil resource utilization,the biological characteristics of tree species,and the impact of coastal storm surges.This study,based on clarifying the connotation of stand quality(SQ)for Casuarina equisetifolia(C.equisetifolia),a typical coastal shelterbelt species,integrates stand growth conditions and structure,applying the AHP-EWM method to construct an SQ evaluation model.The model identifies key factors influencing the quality of C.equisetifolia stands and explores the mechanisms driving their growth processes.The results indicate that mean tree height,mean diameter at breast height,and stand density are key indicators for assessing the SQ of C.equisetifolia stands.The SQ of C.equisetifolia coastal shelterbelt stands varies across different land-sea positions,mainly influenced by stand age and soil nutrient levels.As stand age increases,the SQ initially improves and then declines.Additionally,C.equisetifolia trees growing in nutrient-rich soils exhibit better growth and higher SQ than those in poor soils.The findings of this study provide a theoretical foundation for the management and quality enhancement of coastal shelterbelt forests.
基金supported by the 2024 Henan Province Philosophy and Social Science Planning Project(Youth Project)entitled“Research on the Mechanism and Intervention of Self-Regulated Learning in Promoting Children’s Chinese Reading Comprehension”(2024CJY070).
文摘This study examined the impact of teacher-student relationship quality on students’risk of bullying victimiza-tion and the mediating roles of student-student relationships and student engagement in this relationship.A total of 656 Chinese junior high school students(females=361,mean age=13.75,SD=0.98)completed validated measures of teacher-student relationship quality,student-student relationship quality,student engagement,and bullying victimization.Regression analysis results indicated that higher teacher-student relationship quality predicted a lower risk of student bullying victimization.Serial mediating effect testing of the student-student relationship quality and student engagement revealed that these factors fully mediated the relationship between teacher-student relationship quality and bullying victimization,resulting in a lower risk of bullying victimization.The results showed that student-student relationship quality had a more substantial mediating effect than student engagement.Thefindings support the Socio-Ecological Framework,suggesting that within the Microsystem,interactions between individuals and their immediate environments significantly impact their behavior.Specifically,thesefindings suggest that good teacher-student relationships can enhance the quality of student-student relationships and student engagement,thereby preventing and reducing the occurrence of bullying victimization.
文摘Objective:To investigate the effectiveness of quality management models in enhancing service quality at physical examination centers.Methods:A total of 1,200 examinees who received services at our hospital’s physical examination center between January 2022 and June 2023 were randomly divided into a control group(600 cases)and an observation group(600 cases).The two groups were compared in terms of examination process duration,report quality scores,detection rate of abnormal findings,overall patient satisfaction,and staff job satisfaction.Results:The observation group showed significantly shorter examination time(98.5±15.2 minutes vs 156.3±22.7 minutes,P<0.01),higher report quality scores(92.4±3.5 vs 78.6±6.8 points,P<0.01),improved detection rate of abnormalities(38.7%vs 29.5%,P<0.05),increased patient satisfaction(97.2%vs 82.3%,P<0.01),and greater staff job satisfaction(90.5%vs 72.3%,P<0.01).Conclusion:Quality management models can significantly enhance service quality and operational efficiency at physical examination centers,improve examination outcomes and patient satisfaction,demonstrating substantial clinical application value.
文摘Objective:To evaluate the effectiveness of quality nursing in the management of reusable instruments in the Central Sterile Supply Department(CSSD).Methods:Eleven nurses from the CSSD department were selected from January to October 2024,and quality nursing activities were implemented in the management of reusable instruments.The completion of quality indicators was analyzed.The instrument quality management scores,department satisfaction,and nurses’professional ability scores before and after nursing management were compared.Results:After nursing intervention,the qualified rates of initial cleaning and final cleaning of sterilization instruments were 99.66%and 100%,respectively.The qualified rate of packaging was 99.97%,the wet package rate was 0.1‰,the loading qualified rate was 99.88%,and the qualified rate of distribution was 99.99%.After nursing intervention,the nurses’instrument quality management scores,department satisfaction,and nurses’professional ability scores were all higher than those before nursing intervention(P<0.05).Conclusion:Quality nursing activities can improve the cleaning,packaging,and sterilization qualified rates of reusable instruments in the CSSD,enhance the effect of instrument quality management,obtain higher department satisfaction from nurses,cultivate their professional abilities,and possess significant nursing management advantages.
基金support received by the University of South Africa for a conducive research environment。
文摘Water resources are vital for all living beings and should be managed properly to ensure the safety and well-being of humankind.Surface water bodies are constantly faced with serious contamination risks generated primarily by human activities and urbanization.The problem of waste littering and dumping in developing countries like Nigeria is increasingly affecting environmental resources such as air and water.Several studies have revealed alarming levels of heavy metals that exceed the World Health Organization(WHO)standards.Plastic waste represents a substantial portion of litter,affecting water quality.Pollution results in the depletion of aquatic ecosystems and an increase in water-related diseases.This review aims to assess the impact of waste littering and dumping on surface water quality in Nigeria.In this review,the findings of various studies on surface water bodies in Nigeria,particularly those under the influence of urbanization and waste disposal,were compiled.This review compared numerous physical and chemical parameters like pH,dissolved oxygen,and heavy metals,and microbiological properties such as total coliforms.The water quality index(WQI)was also computed in these studies to ascertain the suitability of the water samples for human consumption.Review results showed that numerous water bodies in Nigeria have significantly diverse water quality levels,with some samples meeting or exceeding the WHO guidelines for microbiological,chemical,and physical characteristics.Notably,levels of heavy metals,turbidity,and pH frequently exceeded permissible limits,pointing to contamination from agricultural and industrial sources.The WQI results for multiple locations revealed that the majority of surface water sources were classified as“bad”to“very bad”,meaning they were unfit for human consumption.The results emphasized the critical need for immediate action to prevent further harm and deterioration of surface water bodies in Nigeria.Recommendations include strengthening waste management policies,promoting recycling initiatives,fostering collaborations among stakeholders,developing littering penalties and enforcing fines to curb the challenge,and raising educational awareness from the primary level.This review emphasizes the need for proactive measures to protect the environment and surface water quality in Nigeria.
基金supported by the fund project of the Key Laboratory of Geological Hazards on Three Gorges Reservoir Area(China Three Gorges University),Hubei Province,China(Grant No.2023KDZ12)Hubei Provincial Engineering Research Center of Slope Habitat Construction Technique Using Cement-based Materials(China Three Gorges University),Hubei Province,China(Grant No.2022SNJ04).
文摘Evaluating soil quality(SQ)is crucial for ensuring the long-term stability of restored slope ecosystems,yet selecting efficient assessment methods remains challenging.The aim of this study was to develop a targeted SQ evaluation system to compare the differences in the effectiveness of ecological restoration methods for slopes.We analysed the characteristics of 18 soil physicochemical and biological indices within a total data set(TDS)for five restored slopes with distinct ecological restoration techniques and three untreated slopes(as the control)in Yichang,China.Principal component analysis,entropy weight method,and Norm were employed to identify a minimum data set(MDS)and four soil quality index(SQI)models,linear unweighted(SQI_(L-A)),linear weighted(SQI_(L-W)),nonlinear unweighted(SQI_(NL-A)),and nonlinear weighted(SQI_(NL-W)),were used to comprehensively evaluate the MDS-based SQ.The results revealed that(1)MDS,consisting of microbial biomass carbon(MBC),microbial biomass phosphorus(MBP),microbial biomass quotient(qMBC),catalase(CAT),and bulk density(BD),effectively characterized the SQ of the ecological restoration slopes;(2)the SQI_(NL-W)model demonstrated superior discrimination among different ecological restoration slopes,with a significantly greater coefficient of determination(R^(2)=0.881,P<0.01)than other SQI models;and(3)all five ecological restoration techniques effectively improved SQ of slope to varying degrees,elevating it from low to high levels,with the vegetative cement-soil eco-restoration&vegetation concrete eco-restoration technique demonstrating the best effect(SQI_(NL-W)=0.627).Our study developed a practical SQ evaluation system based on the validated MDS and the most suitable SQI model(SQI_(NL-W)).This system enables reliable assessment on the effectiveness of restoration techniques.
基金supported by the Hunan Province Municipal Natural Science Foundation(2022JJ30018)the Hunan Province Health Commission Science Foundation(B202301037899)to WNL。
文摘This study explores whether the current external quality assessment(EQA)level and acceptable bias for basic semen analysis in China are clinically useful.We collected data of semen EQA from Andrology laboratories in the Hunan Province(China)in 2022 and searched for data in the published literature from January2000 to December 2023 in China.On the basis of these data,we analyzed the coefficients of variation and acceptable biases of different quality control materials for basic semen analysis through robust statistics.We compared these findings with quality specifications based on biological variation from optimal,desirable,and minimum levels of bias to seek a unified and more suitable semen EQAbias evaluation standard for China's national conditions.Different sources of semen quality control material exhibited considerable variation in acceptable biases among laboratories,ranging from 8.2%to 56.9%.A total of 50.0% of the laboratories met the minimum quality specifications for progressive motility(PR),whereas 100.0%and 75.0%of laboratories met only the minimum quality specifications for sperm concentration and total motility(nonprogressive[NP]+PR),respectively.The Z value for sperm concentration and PR+NP was equivalent to the desirable performance specification,whereas the Z value for PR was equivalent only to the minimum performance specification.This study highlights the feasibility of operating external quality assessment schemes for basic semen analysis using quality specifications based on biological variation.These specifications should be unified among external quality control(EQC)centers based on biological variation.
基金Supported by Taishan Scholar Special Funding,No.tsqnz20240858Medical and Health Technology Project of Shandong Province,No.202402050122+4 种基金Science and Technology Development Plan of Jinan Municipal Health Commission,No.2024301008Clinical Medical Science and Technology Innovation Program of Jinan Science and Technology Bureau,No.202430055Natural Science Foundation of Jiangxi Province,No.20224BAB206077Gansu Provincial Hospital Intra-Hospital Research Fund Project,No.22GSSYB-6and the 2022 Master/Doctor/Postdoctoral Program of National Health Commission Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor,No.NHCDP2022004 and No.NHCDP2022008.
文摘Knee osteoarthritis(KOA),characterized by heterogeneous arthritic manifestations and complex peripheral joint disorder,is one of the leading causes of disability worldwide,which has become a high burden due to the multifactorial nature and the deficiency of available disease-modifying treatments.The application of mesenchymal stem/stromal cells(MSCs)as therapeutic drugs has provided novel treatment options for diverse degenerative and chronic diseases including KOA.However,the complexity and specificity of the“live”cells have posed challenges for MSC-based drug development and the concomitant scale-up preparation from laboratory to industrialization.For instance,despite the considerable progress in ex vivo cell culture technology for fulfilling the robust development of drug conversion and clinical trials,yet significant challenges remain in obtaining regulatory approvals.Thus,there’s an urgent need for the research and development of MSC drugs for KOA.In this review,we provide alternative solution strategies for the preparation of MSC drugs on the basis of the principle of quality by design,including designing the cell production processes,quality control,and clinical applications.In detail,we mainly focus on the quality by design method for MSC manufacturing in standard cell-culturing factories for the treatment of KOA by using the Quality Target Product Profile as a starting point to determine potential critical quality attributes and to establish relationships between critical material attributes and critical process parameters.Collectively,this review aims to meet product performance and robust process design,and should help to reduce the gap between compliant products and the production of compliant good manufacturing practice.
基金The support provided by the National Natural Science Foundation of China(Grant No.42277160)the Natural Science Foundation of Hubei Province(Grant No.2021CFA081)the Fundamental Research Funds for the Central Universities(Grant No.2042023kf0210)is gratefully acknowledged.
文摘The evaluation of rock mass quality and its mechanical properties is crucial for tunnel construction.The basic quality(BQ)method is the national standard for rock mass classification in China,with the BQ value determined by the uniaxial compressive strength(UCS)and the integrity index(Kv).However,traditional rock mechanics testing methods have inherent limitations,which complicate the rapid evaluation of rock mass quality at tunnel sites.Digital drilling process monitoring(DPM)offers a novel approach for evaluating rock mass quality and its mechanical properties.A hydraulic rotary drilling rig,equipped with the DPM system,was used to conduct digital drilling tests at the tunnel face.The DPM data for the net drilling process and each sub-process were then analyzed.The correlations between DPM parameter indices and rock mechanical parameters were investigated.Finally,the rock mass quality and its mechanical properties along three boreholes were evaluated.The results indicate that drilling speed in the linear zone(V_(DPM))is quantitatively correlated with rock UCS.Higher UCS values of the drilled rocks correspond to lower V_(DPM) values of the drilling rig.The variability in specific energy is associated with structural disturbances within the rock mass.There is an approximately linear relationship between the standard deviation of normalized specific energy and rock mass K_(v) across the three boreholes.The rock mass quality along drilling depth generally ranges from good(Ⅰ-Ⅱ)to poor(Ⅲ-Ⅴ).This digitalization method provides more detailed information for tunnel stability analysis and design optimization than geological survey data.
文摘BACKGROUND Although transarterial chemoembolization(TACE)is an effective treatment for liver cancer,clinical practice has shown that many patients experience significant psychological distress following the procedure,which can hinder postoperative recovery and prognosis.Therefore,effective and evidence-based interventions are urgently needed to address this issue.AIM To evaluate the impact of nursing quality-sensitive indicators combined with mindfulness-based stress reduction(MBSR)interventions in patients undergoing TACE.METHODS A total of 84 patients who underwent TACE from June 2022 to March 2024 were enrolled in the study.They were randomly assigned to either the observation group(n=42),which received nursing quality-sensitive indicator-based care combined with MBSR intervention,or the control group(n=42),which received routine care combined with MBSR intervention.Psychological stress response levels[assessed using the Trait Meta-Mood Scale(TMMS)],coping strategies[measured with the Jalowiec Coping Scale(JCS)],quality of care[evaluated using the Perceived Nursing Service Quality(PNSQ)scale],and overall patient satisfaction were compared between the two groups.RESULTS After 4 weeks,the observation group demonstrated significantly higher TMMS scores,as well as increased optimism,support-seeking,bravery,PNSQ scores,and satisfaction(P<0.05).In contrast,scores for selfdependence,conservatism,resignation,and avoidance in the JCS were significantly lower in the observation group than in the control group(P<0.05).CONCLUSION The combination of nursing quality-sensitive indicators and MBSR intervention in TACE patients not only reduces psychological stress and encourages a more positive attitude toward illness but also enhances nursing quality and improves the overall patient experience.
基金supported by the National Natural Science Foundation of China(42377072,52409105).
文摘Water quality is a pressing issue affecting the sustainable development of lakes.To elucidate the spatial and temporal characteristics of water quality in Bos ten Lake,China,this study constructed a comprehensive water quality index(CWQI) based on key water quality indicators,utilizing water quality data collected from 17 sampling sites spaning from 2011 to 2019.Key water quality indicators were determined using factor analysis,and the spatial and temporal characteristics of key water quality indicators and the CWQI were examined using multivariate statistical analysis.The key water quality indicators included pH,chemical oxygen demand(COD),water transparency(SD),NO3-,total dissolved solids(TDS),Cl-,SO42-,and electrical conductivity(EC).Furthermore,the contribution rates of all water quality indicators to the water quality were quantitatively elucidated using the SHapley Additive explanations(SHAP) values,thereby validating the factor analysis outcomes.Among the eight key water quality indicators,the COD had the most significant influence on the water quality of Bos ten Lake.The water quality condition of Bosten Lake has remained at Class Ⅲ from 2011 to 2019(CWQI ranging from3.19 to 3.90).The water quality of Bos ten Lake was characterized by distinct regional differences that arose from hydrodynamic processes within the lake and upstream water quality.The southwestern region exhibited the best water quality(mean CWQI of 3.47),whereas the northwestern region exhibited the worst(mean CWQI of 3.58).It is crucial to acknowledge that alongside the increase in industrial and agricultural effluent discharge monitoring,a series of ecological restoration projects for the lake basin have been initiated.Over time,the water quality of Bosten Lake showed gradual improvement(improvement rate of CWQI at 0.05/a).This study provides a critical scientific basis for enhancing the understanding and effective management of water quality in the Bosten Lake Basin through a comprehensive analysis of its spatial and temporal evolution and driving mechanisms.
基金funded by grants from the General Project of the National Social Science Fund:“Research on the Interactive Mechanism of Migrant Workers Returning to Their Hometowns for Entrepreneurship and Rural Revitalization in the Major Labor Export Provinces”(20BJY136)General Project of Sichuan Provincial Philosophy and Social Science Fund:“The Era Significance,Growth Constraints,and Path Optimization of the New Agricultural Laborers from the Perspective of the New Quality Productive Forces”(SCJJ24ND065)Key Project of the Sichuan Academy of Social Sciences:“The Era Significance,Current Concerns,and Action Prospects of the New Agricultural Laborers from the Perspective of the New Quality Productive Forces”(24XD02).
文摘Driven by technological innovation and the innovative allocation of production factors,new quality productive forces(NQPFs)are a key breakthrough and core element propelling China’s transition from a major agricultural country to an advanced agricultural nation.At its core,agricultural modernization represents a frontier shift in agricultural development-a dynamic evolution of productive forces across technological forms,farmer demographics,industrial structures,and urban-rural relations.NQPFs drive the high-quality,integrated development of agricultural modernization through agricultural technological innovation,green and low-carbon practices,and the enhancement of all production factors.As NQPFs evolve and agricultural modernization advances,we must address constraints stemming from gaps in technology,models,resources,and talent.Furthermore,we must foster deep integration among industry,research,and education to develop new pathways for industrial upgrading,promote green and efficient agricultural development,and bridge existing technological gaps.These collective efforts are crucial for accelerating the high-quality development of agricultural modernization.
文摘Objective:To explore the effects of high-quality nursing intervention on negative emotions and quality of life in gynecological patients after laparoscopy.Methods:A total of 132 gynecological patients after laparoscopy were randomly divided into an observation group(n=66)and a control group(n=66)in a prospective study.The con-trol group received routine nursing care,while the observation group received high-quality nursing intervention.Anxiety,depression,quality of life,postoperative pain,self-care ability,and patient satisfaction were compared between the two groups.Results:The Self-Rating Anxiety Scale and Self-Rating Depression Scale scores were sig-nificantly lower in the observation group compared to the control group(both P<0.001).Pain scores at 6,24,48,and 72 hours post-surgery were also lower in the observation group(all P<0.001).The observation group showed significantly higher scores in physical function,general health,social function,emotional role,and mental health(all P<0.001).Furthermore,the observation group demonstrated better self-care skills,self-concept,self-care responsibility,and health knowledge(all P<0.001).Nursing satisfaction during hospitalization was significantly higher in the observation group than in the control group(P<0.05).Conclusion:High-quality nursing intervention is effective in improving depression,anxiety,postoperative pain,and quality of life in gynecological patients after laparoscopy.It also enhances self-care ability and patient satisfaction,making it worthy of clinical promotion and application.
