目的:探讨精神分裂症长期服药患者经心率校正的QT(QTc)间期延长的危险因素。方法:230例住院的精神分裂症长期服药患者,分为QTc间期延长组69例和非QTc间期正常组161例。比较两组临床特征及血液生化指标,采用单因素及多因素Logistic回归...目的:探讨精神分裂症长期服药患者经心率校正的QT(QTc)间期延长的危险因素。方法:230例住院的精神分裂症长期服药患者,分为QTc间期延长组69例和非QTc间期正常组161例。比较两组临床特征及血液生化指标,采用单因素及多因素Logistic回归分析影响长期使用抗精神病药物患者QTc间期延长的危险因素,绘制受试者工作特征(receiver operating characteristic,ROC)曲线评估模型判别力。结果:QTc间期延长组体质量指数(body mass index,BMI)、氯丙嗪当量高于QTc正常组(均P<0.05)。QTc间期延长组总胆固醇、低密度脂蛋白、胆固醇、尿素氮水平低于非延长组(均P<0.05),而总胆红素、直接胆红素、肌酐水平均高于QTc间期正常组(均P<0.05)。多因素Logistic回归分析显示,氯丙嗪当量(OR=1.002,P=0.003)和直接胆红素(OR=1.465,P<0.001)为QTc间期延长的独立危险因素。结论:直接胆红素升高和抗精神病药物剂量增加是长期使用抗精神病药物的精神分裂症住院患者QTc延长的独立危险因素。展开更多
Atrial fibrillation(AF)is the most common arrhythmia in clinical setting and has been increasingly prevalent due to the aging population.AF is associated with a three to fivefold increased risk of stroke.Treatment opt...Atrial fibrillation(AF)is the most common arrhythmia in clinical setting and has been increasingly prevalent due to the aging population.AF is associated with a three to fivefold increased risk of stroke.Treatment options include pharmacological and electrical cardioversion,each carrying specific risks.AF may resolve spontaneously,but often recurs,making a“watch-andwait”strategy a reasonable approach to avoid unnecessary antiarrhythmic therapy.展开更多
文摘目的:探讨精神分裂症长期服药患者经心率校正的QT(QTc)间期延长的危险因素。方法:230例住院的精神分裂症长期服药患者,分为QTc间期延长组69例和非QTc间期正常组161例。比较两组临床特征及血液生化指标,采用单因素及多因素Logistic回归分析影响长期使用抗精神病药物患者QTc间期延长的危险因素,绘制受试者工作特征(receiver operating characteristic,ROC)曲线评估模型判别力。结果:QTc间期延长组体质量指数(body mass index,BMI)、氯丙嗪当量高于QTc正常组(均P<0.05)。QTc间期延长组总胆固醇、低密度脂蛋白、胆固醇、尿素氮水平低于非延长组(均P<0.05),而总胆红素、直接胆红素、肌酐水平均高于QTc间期正常组(均P<0.05)。多因素Logistic回归分析显示,氯丙嗪当量(OR=1.002,P=0.003)和直接胆红素(OR=1.465,P<0.001)为QTc间期延长的独立危险因素。结论:直接胆红素升高和抗精神病药物剂量增加是长期使用抗精神病药物的精神分裂症住院患者QTc延长的独立危险因素。
文摘Atrial fibrillation(AF)is the most common arrhythmia in clinical setting and has been increasingly prevalent due to the aging population.AF is associated with a three to fivefold increased risk of stroke.Treatment options include pharmacological and electrical cardioversion,each carrying specific risks.AF may resolve spontaneously,but often recurs,making a“watch-andwait”strategy a reasonable approach to avoid unnecessary antiarrhythmic therapy.
