Background:There have been few reports on long-term survival of gastric cancer patients.This study analyzed the survival data of gastric cancer patients obtained from the population-based Qidong Cancer Registry betwee...Background:There have been few reports on long-term survival of gastric cancer patients.This study analyzed the survival data of gastric cancer patients obtained from the population-based Qidong Cancer Registry between 1972 and 2011,providing a basis for evaluation of gastric cancer treatment and prognosis.Methods:The cumulative observed survival rate and relative survival rate of gastric cancer patients were calculated using Hakulinen's method via the SURV3.01 software,which was developed by the Finnish Cancer Registry.The date of the last follow-up for the survival status of the 15,401 registered cases was April 30,2012.Results:The 1-,5-,10-,20-,and 30-year observed survival rates were 33.82%,14.18%,10.35%,6.63%,and 4.19%,respectively,and the 1-,5-,10-,20-,and 30-year relative survival rates were 35.43%,18.13%,17.50%,21.96%,and32.84%,respectively.For males,the corresponding observed survival rates were 34.50%,14.40%,10.42%,6.46%,and4.05%,and the corresponding relative survival rates were 36.23%,18.67%,18.28%,23.73%,and 38.61%.For females,the corresponding observed survival rates were 32.62%,13.80%,10.22%,6.95%,and 4.46%,and the corresponding relative survival rates were 34.03%,17.21%,16.28%,19.70%,and 26.78%.Significant differences in relative survival rates were observed between sexes(P=0.003).For the 15-34,35-44,45-54,55-64,65-74,and 75+ age groups,the 5-year relative survival rates were 16.13%,21.77%,18.63%,12.61%,7.99%,and 2.94%,respectively,and the 10-year relative survival rates were 16.49%,22.83%,20.50%,15.97%,15.88%,and 15.73%,respectively.Remarkable improvement could be observed for the 5-,10-,and 15-year relative survival rates in Qidong beginning in the 1980 s.Conclusion:The survival outcome of registered gastric cancer cases in Qidong showed gradual progress over the past two decades.展开更多
OBJECTIVE:To evaluate the efficacy of Qidong Huoxue decoction(芪冬活血饮,QDHX)in treating acute lung injury and acute respiratory distress syndrome(ALI/ARDS)when used as an adjunctive treatment.METHODS:ALI/ARDS patien...OBJECTIVE:To evaluate the efficacy of Qidong Huoxue decoction(芪冬活血饮,QDHX)in treating acute lung injury and acute respiratory distress syndrome(ALI/ARDS)when used as an adjunctive treatment.METHODS:ALI/ARDS patients admitted to our medical intensive care unit were randomly allocated to the control group or the QDHX group and received standard therapy.The QDHX group received QDHX(50 mL per day for 14 d)orally or via a gastric tube.The primary outcome was measured according to Traditional Chinese Medicine(TCM)syndrome scores,with partial pressure of oxygen/fraction of inspired oxygen(PaO_(2)/FiO_(2))levels as the secondary outcome.RESULTS:A total of 73 patients completed the study(36 in the TCM and 37 in the conventional group),and their records were analyzed.After 14-d treatment,the TCM group showed a significant decrease in TCM syndrome scores(P<0.05)and increased PaO_(2)/FiO_(2) levels(P<0.05).The therapeutic effect of integrated Chinese and western medicine was more significant than that of Western Medicine alone.No serious side effects were observed.CONCLUSIONS:Our study results show that QDHX in combination with conventional drug therapy can significantly reduce some clinical symptoms in patients with ALI/ARDS.展开更多
The occurrence state of methane is mostly controlled by coalfield geologicalstructures.The coal-bearing strata at Qidong coalmine experienced many tectonic cyclessince their formation.The gas content made by the compl...The occurrence state of methane is mostly controlled by coalfield geologicalstructures.The coal-bearing strata at Qidong coalmine experienced many tectonic cyclessince their formation.The gas content made by the complicated structural geologic systemat the coalfield is very different, which is obviously higher on the north side of the Weimiaofracture belt than that on the south side and near itself.This thesis discussed the gas occurrenceregularity based on the geometric characteristics of the geological structure andits regional tectonic evolution.This study can provide a foundation for coalfield exploitationand deal with coal and gas outburst.展开更多
The sedimentation rate is an important environmental parameter to understand the evolution of coastal geomorphology. The tidal flat around Qidong foreland is located in the junction between Yangtze Estuary and Jiangsu...The sedimentation rate is an important environmental parameter to understand the evolution of coastal geomorphology. The tidal flat around Qidong foreland is located in the junction between Yangtze Estuary and Jiangsu coast,where the land-ocean interactions are strong and highly sensitive to environmental changes. The QDZ-1 core sediments collected at Qidong foreland was analyzed for137 Cs dating and grain size.The results showed that silt is the main sedimentary type with a trend of gradually fining from the bottom to the top,conforming to the sedimentation characteristic of the silt muddy tidal flat. The sedimentation rate could be divided into three distinct stages: 1963 to 1986 was 2. 61 cm/yr,1963 to 2011 was 1. 82 cm/yr,and 1986 to 2011 was 1. 10 cm/yr. Based on these,further explanation was made for the significance of environmental changes. According to the estimation of sedimentation rate,the impact of extreme environmental change was reflected by the sudden increase in sand proportion at the depth of 172. 5 cm. Since the introduction of Spartina alterniflora in the 1970 s,it has played an important role in tidal flat development. The tidal flat has a high sedimentary rate during this time. With continuous accretion of the tidal flat,low tidal flat turns to high tidal flat,the sedimentation rate gradually declines,and tidal flat sedimentation appears.展开更多
O6-methylguanine DNA methyltransferase (O6-AT) is an enzyme for the repair of the promutagenic structure, O6-aIkylguanine, from alkylated DNA, therefore low activity of O6-AT is involved in the predisposition of tissu...O6-methylguanine DNA methyltransferase (O6-AT) is an enzyme for the repair of the promutagenic structure, O6-aIkylguanine, from alkylated DNA, therefore low activity of O6-AT is involved in the predisposition of tissues to some nitrosamines and the development of cancer. The levels of O6-AT in livers of ducks from Qidong (Qd), a high incidence area of liver cancer, and from Qingpu(Qp), a relatively low incidence area were determined in this study. The results showed that the activity of O6-AT was higher in Qp than in Qd. It suggested that some nitrosamine in Qd might be one of factors responsible for the higher incidence of ducks liver cancer, because these ducks were more sensitive to nitrosa-mine.展开更多
目的:通过网络药理学和分子对接技术探讨芪冬活血饮治疗肺纤维化(pulmonary fibrosis, PF)的潜在机制。方法:通过中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, TCMSP)、本草组鉴...目的:通过网络药理学和分子对接技术探讨芪冬活血饮治疗肺纤维化(pulmonary fibrosis, PF)的潜在机制。方法:通过中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, TCMSP)、本草组鉴(a High-Throughput Experiment-and-Reference-Guided Database of Traditional Chinese Medicine, HERB)数据库检索出芪冬活血饮中各中药的主要活性化学成分及其对应的靶点,并借助人类基因数据库(Genecards Human Gene Database, GeneCards)、基因疾病关联(Disease Gene Network, DisGeNET)数据库收集PF疾病相关的靶点基因。使用Venny、蛋白质相互作用数据库(Search Tool for the Retrieval of Interacting Genes/Proteins, STRING)和Cytoscape分析共同靶点并构建蛋白质-蛋白质相互作用(protein-protein interaction, PPI)网络。利用基因功能注释与集成分析数据库(Database for Annotation, Visualization and Integrated Discovery, DAVID)进行共同靶点的基因本体(gene ontology, GO)功能、京都基因与基因组数据库(Kyoto Encyclopedia of Genes and Genomes, KEGG)通路富集分析。运用AutoDock软件进行分子对接模拟,验证研究结果。结果:芪冬活血饮包含34个活性成分及221个潜在作用靶点,其中有131个靶点与PF相关基因重叠。筛选出包括肿瘤坏死因子(tumor necrosis factor, TNF)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-1β(interleukin-1 beta, IL-1β)等10个核心靶点。GO功能和KEGG通路分析发现,芪冬活血饮通过参与调节基因表达、细胞增殖和凋亡等生物过程,调控高级糖基化终产物/受体(advanced glycation end products/receptor for advanced glycation end products, AGE/RAGE)、白细胞介素17(interleukin-17,IL-17)、TNF、磷脂酰肌醇3激酶/蛋白激酶B(phosphatidylinositol 3-kinase/protein pinase B,PI3K/Akt)等信号通路对PF发挥治疗作用。分子对接结果表明,活性成分与核心靶点之间具有较强的结合亲和力,进一步支持了其药理学的相关性。结论:本研究揭示了芪冬活血饮可能通过干预AGE/RAGE、IL-17、TNF、PI3K/Akt等信号通路,影响炎症因子网络,减少成纤维细胞异常增殖及细胞外基质(extracellular matrix, ECM)过度沉积,从而缓解PF病理损伤,为后续研究和开发新型治疗策略提供了科学依据。展开更多
基金supported partially by the National Central Cancer Registries of China(the Tumor Follow-up Registration Programs MF2008293,2009-193,and 2010-90)by the National Science and Technology Mega-Projects of China(2012ZX100020009-018 and 2012ZX10002-008)
文摘Background:There have been few reports on long-term survival of gastric cancer patients.This study analyzed the survival data of gastric cancer patients obtained from the population-based Qidong Cancer Registry between 1972 and 2011,providing a basis for evaluation of gastric cancer treatment and prognosis.Methods:The cumulative observed survival rate and relative survival rate of gastric cancer patients were calculated using Hakulinen's method via the SURV3.01 software,which was developed by the Finnish Cancer Registry.The date of the last follow-up for the survival status of the 15,401 registered cases was April 30,2012.Results:The 1-,5-,10-,20-,and 30-year observed survival rates were 33.82%,14.18%,10.35%,6.63%,and 4.19%,respectively,and the 1-,5-,10-,20-,and 30-year relative survival rates were 35.43%,18.13%,17.50%,21.96%,and32.84%,respectively.For males,the corresponding observed survival rates were 34.50%,14.40%,10.42%,6.46%,and4.05%,and the corresponding relative survival rates were 36.23%,18.67%,18.28%,23.73%,and 38.61%.For females,the corresponding observed survival rates were 32.62%,13.80%,10.22%,6.95%,and 4.46%,and the corresponding relative survival rates were 34.03%,17.21%,16.28%,19.70%,and 26.78%.Significant differences in relative survival rates were observed between sexes(P=0.003).For the 15-34,35-44,45-54,55-64,65-74,and 75+ age groups,the 5-year relative survival rates were 16.13%,21.77%,18.63%,12.61%,7.99%,and 2.94%,respectively,and the 10-year relative survival rates were 16.49%,22.83%,20.50%,15.97%,15.88%,and 15.73%,respectively.Remarkable improvement could be observed for the 5-,10-,and 15-year relative survival rates in Qidong beginning in the 1980 s.Conclusion:The survival outcome of registered gastric cancer cases in Qidong showed gradual progress over the past two decades.
基金Zhejiang Province Traditional Chinese Medicine Science and Technology Plan:the Study on Clinical Effects of Qidong Huoxue decoction in the Treatment of Acute Lung Injury(No.2017ZZ008)。
文摘OBJECTIVE:To evaluate the efficacy of Qidong Huoxue decoction(芪冬活血饮,QDHX)in treating acute lung injury and acute respiratory distress syndrome(ALI/ARDS)when used as an adjunctive treatment.METHODS:ALI/ARDS patients admitted to our medical intensive care unit were randomly allocated to the control group or the QDHX group and received standard therapy.The QDHX group received QDHX(50 mL per day for 14 d)orally or via a gastric tube.The primary outcome was measured according to Traditional Chinese Medicine(TCM)syndrome scores,with partial pressure of oxygen/fraction of inspired oxygen(PaO_(2)/FiO_(2))levels as the secondary outcome.RESULTS:A total of 73 patients completed the study(36 in the TCM and 37 in the conventional group),and their records were analyzed.After 14-d treatment,the TCM group showed a significant decrease in TCM syndrome scores(P<0.05)and increased PaO_(2)/FiO_(2) levels(P<0.05).The therapeutic effect of integrated Chinese and western medicine was more significant than that of Western Medicine alone.No serious side effects were observed.CONCLUSIONS:Our study results show that QDHX in combination with conventional drug therapy can significantly reduce some clinical symptoms in patients with ALI/ARDS.
基金Supported by the National Natural Science Foundation of China(40872103)
文摘The occurrence state of methane is mostly controlled by coalfield geologicalstructures.The coal-bearing strata at Qidong coalmine experienced many tectonic cyclessince their formation.The gas content made by the complicated structural geologic systemat the coalfield is very different, which is obviously higher on the north side of the Weimiaofracture belt than that on the south side and near itself.This thesis discussed the gas occurrenceregularity based on the geometric characteristics of the geological structure andits regional tectonic evolution.This study can provide a foundation for coalfield exploitationand deal with coal and gas outburst.
基金Supported by National Natural Science Foundation of China(Grant No.:41501003,41701101,41807403)Open Foundation of Research Institute of Jiangsu Coastal Development(Grant No.:RIJCD11008)
文摘The sedimentation rate is an important environmental parameter to understand the evolution of coastal geomorphology. The tidal flat around Qidong foreland is located in the junction between Yangtze Estuary and Jiangsu coast,where the land-ocean interactions are strong and highly sensitive to environmental changes. The QDZ-1 core sediments collected at Qidong foreland was analyzed for137 Cs dating and grain size.The results showed that silt is the main sedimentary type with a trend of gradually fining from the bottom to the top,conforming to the sedimentation characteristic of the silt muddy tidal flat. The sedimentation rate could be divided into three distinct stages: 1963 to 1986 was 2. 61 cm/yr,1963 to 2011 was 1. 82 cm/yr,and 1986 to 2011 was 1. 10 cm/yr. Based on these,further explanation was made for the significance of environmental changes. According to the estimation of sedimentation rate,the impact of extreme environmental change was reflected by the sudden increase in sand proportion at the depth of 172. 5 cm. Since the introduction of Spartina alterniflora in the 1970 s,it has played an important role in tidal flat development. The tidal flat has a high sedimentary rate during this time. With continuous accretion of the tidal flat,low tidal flat turns to high tidal flat,the sedimentation rate gradually declines,and tidal flat sedimentation appears.
文摘O6-methylguanine DNA methyltransferase (O6-AT) is an enzyme for the repair of the promutagenic structure, O6-aIkylguanine, from alkylated DNA, therefore low activity of O6-AT is involved in the predisposition of tissues to some nitrosamines and the development of cancer. The levels of O6-AT in livers of ducks from Qidong (Qd), a high incidence area of liver cancer, and from Qingpu(Qp), a relatively low incidence area were determined in this study. The results showed that the activity of O6-AT was higher in Qp than in Qd. It suggested that some nitrosamine in Qd might be one of factors responsible for the higher incidence of ducks liver cancer, because these ducks were more sensitive to nitrosa-mine.
文摘目的:通过网络药理学和分子对接技术探讨芪冬活血饮治疗肺纤维化(pulmonary fibrosis, PF)的潜在机制。方法:通过中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, TCMSP)、本草组鉴(a High-Throughput Experiment-and-Reference-Guided Database of Traditional Chinese Medicine, HERB)数据库检索出芪冬活血饮中各中药的主要活性化学成分及其对应的靶点,并借助人类基因数据库(Genecards Human Gene Database, GeneCards)、基因疾病关联(Disease Gene Network, DisGeNET)数据库收集PF疾病相关的靶点基因。使用Venny、蛋白质相互作用数据库(Search Tool for the Retrieval of Interacting Genes/Proteins, STRING)和Cytoscape分析共同靶点并构建蛋白质-蛋白质相互作用(protein-protein interaction, PPI)网络。利用基因功能注释与集成分析数据库(Database for Annotation, Visualization and Integrated Discovery, DAVID)进行共同靶点的基因本体(gene ontology, GO)功能、京都基因与基因组数据库(Kyoto Encyclopedia of Genes and Genomes, KEGG)通路富集分析。运用AutoDock软件进行分子对接模拟,验证研究结果。结果:芪冬活血饮包含34个活性成分及221个潜在作用靶点,其中有131个靶点与PF相关基因重叠。筛选出包括肿瘤坏死因子(tumor necrosis factor, TNF)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-1β(interleukin-1 beta, IL-1β)等10个核心靶点。GO功能和KEGG通路分析发现,芪冬活血饮通过参与调节基因表达、细胞增殖和凋亡等生物过程,调控高级糖基化终产物/受体(advanced glycation end products/receptor for advanced glycation end products, AGE/RAGE)、白细胞介素17(interleukin-17,IL-17)、TNF、磷脂酰肌醇3激酶/蛋白激酶B(phosphatidylinositol 3-kinase/protein pinase B,PI3K/Akt)等信号通路对PF发挥治疗作用。分子对接结果表明,活性成分与核心靶点之间具有较强的结合亲和力,进一步支持了其药理学的相关性。结论:本研究揭示了芪冬活血饮可能通过干预AGE/RAGE、IL-17、TNF、PI3K/Akt等信号通路,影响炎症因子网络,减少成纤维细胞异常增殖及细胞外基质(extracellular matrix, ECM)过度沉积,从而缓解PF病理损伤,为后续研究和开发新型治疗策略提供了科学依据。
