[Objectives]To establish a multi-indicator quality control method for the retention of Longqing Capsule based on the principle of prescription of Chinese medicine.[Methods]High performance liquid chromatography(HPLC)w...[Objectives]To establish a multi-indicator quality control method for the retention of Longqing Capsule based on the principle of prescription of Chinese medicine.[Methods]High performance liquid chromatography(HPLC)with ShimNex CS C 18 as the column;column temperature:35℃;wavelength:270 nm;methanol-0.1%phosphoric acid solution as the mobile phase with gradient elution.[Results]The 12 components of the retention of Longqing Capsule showed good linearity within the investigated range(r≥0.9995),with the average spiked recoveries of 97.83%-100.52%and the RSD of 0.9%-2.1%.[Conclusions]The method is exclusive,sensitive,reproducible,simple and easy to use,and can provide a reference for the construction of the quality standard and control system of Longqing Capsule based on the theory of traditional Chinese medicine.展开更多
The performance of an OFDM/OQAM system under phase noise is analyzed. The analysis helps to direct the design of low cost tuners through specifying the required phase noise characteristics. Discrete time formulation o...The performance of an OFDM/OQAM system under phase noise is analyzed. The analysis helps to direct the design of low cost tuners through specifying the required phase noise characteristics. Discrete time formulation of OFDM/OQAM is first derived with the square root raised cosine (SRRC) filter as the pulse-shaping filter. Then the effect of multiplicative phase noise is equivalently represented as additive white Gaussian noise (AWGN), the variance of which is given analytically. We can observe that the same result as OFDM/QAM system is derived. Lastly, all the analytical results are verified by the bit error rate (BER) degradation through Monte Carlo simulation.展开更多
目的:结合特征图谱、多指标含量测定、化学计量学技术以及一测多评法(quantitative analysis of multi-components by single-marker,QAMS)实现药材、中间体和制剂的多成分同步测定,用于评价益脉康制剂的整体质量。方法:采用Waters XBri...目的:结合特征图谱、多指标含量测定、化学计量学技术以及一测多评法(quantitative analysis of multi-components by single-marker,QAMS)实现药材、中间体和制剂的多成分同步测定,用于评价益脉康制剂的整体质量。方法:采用Waters XBridge BEH C_(18)色谱柱(250 mm×4.6 mm,5μm),流动相为乙腈和0.2%磷酸水溶液,梯度洗脱,流速1.0 m L·min^(-1),柱温30℃,检测波长327 nm。建立HPLC特征图谱,进行相似度分析。采用一测多评法定量分析19批样品中5种成分的含量,研究质量传递过程,并采用雷达图分析、聚类分析、主成分分析和正交偏最小二乘-判别法对含量数据进行分析。结果:建立了19批益脉康制剂HPLC特征图谱,确认了5种成分,分别是新绿原酸、绿原酸、隐绿原酸、野黄芩苷和灯盏花甲素,其含量在线性范围内呈良好的线性关系(r≥0.9990),精密度、重复性、稳定性、加样回收率试验均良好。药材-中间体-制剂各成分的一测多评计算结果与外标法无显著差异;化学计量学分析确定了2个差异标志物,分别是野黄芩苷和灯盏花甲素。结论:所建分析方法稳定、可行,特征图谱、HPLC-QAMS多指标成分含量测定结合化学计量学的方法可实现益脉康制剂的整体质量评价,为其质量控制提供参考。展开更多
基金Supported by Provincial University Scientific Research Platform Team Project of Guizhou Provincial Department of Education(Qianjiaoji[2022]No.010).
文摘[Objectives]To establish a multi-indicator quality control method for the retention of Longqing Capsule based on the principle of prescription of Chinese medicine.[Methods]High performance liquid chromatography(HPLC)with ShimNex CS C 18 as the column;column temperature:35℃;wavelength:270 nm;methanol-0.1%phosphoric acid solution as the mobile phase with gradient elution.[Results]The 12 components of the retention of Longqing Capsule showed good linearity within the investigated range(r≥0.9995),with the average spiked recoveries of 97.83%-100.52%and the RSD of 0.9%-2.1%.[Conclusions]The method is exclusive,sensitive,reproducible,simple and easy to use,and can provide a reference for the construction of the quality standard and control system of Longqing Capsule based on the theory of traditional Chinese medicine.
文摘The performance of an OFDM/OQAM system under phase noise is analyzed. The analysis helps to direct the design of low cost tuners through specifying the required phase noise characteristics. Discrete time formulation of OFDM/OQAM is first derived with the square root raised cosine (SRRC) filter as the pulse-shaping filter. Then the effect of multiplicative phase noise is equivalently represented as additive white Gaussian noise (AWGN), the variance of which is given analytically. We can observe that the same result as OFDM/QAM system is derived. Lastly, all the analytical results are verified by the bit error rate (BER) degradation through Monte Carlo simulation.
文摘目的:结合特征图谱、多指标含量测定、化学计量学技术以及一测多评法(quantitative analysis of multi-components by single-marker,QAMS)实现药材、中间体和制剂的多成分同步测定,用于评价益脉康制剂的整体质量。方法:采用Waters XBridge BEH C_(18)色谱柱(250 mm×4.6 mm,5μm),流动相为乙腈和0.2%磷酸水溶液,梯度洗脱,流速1.0 m L·min^(-1),柱温30℃,检测波长327 nm。建立HPLC特征图谱,进行相似度分析。采用一测多评法定量分析19批样品中5种成分的含量,研究质量传递过程,并采用雷达图分析、聚类分析、主成分分析和正交偏最小二乘-判别法对含量数据进行分析。结果:建立了19批益脉康制剂HPLC特征图谱,确认了5种成分,分别是新绿原酸、绿原酸、隐绿原酸、野黄芩苷和灯盏花甲素,其含量在线性范围内呈良好的线性关系(r≥0.9990),精密度、重复性、稳定性、加样回收率试验均良好。药材-中间体-制剂各成分的一测多评计算结果与外标法无显著差异;化学计量学分析确定了2个差异标志物,分别是野黄芩苷和灯盏花甲素。结论:所建分析方法稳定、可行,特征图谱、HPLC-QAMS多指标成分含量测定结合化学计量学的方法可实现益脉康制剂的整体质量评价,为其质量控制提供参考。
