The ratio of 36Cl/Cl can determine the exposure age of surface rocks and monitor the secular equilibrium of 36Cl of sedimentary and igneous rock in groundwater. Due to the uncertainty effects of different chemical sep...The ratio of 36Cl/Cl can determine the exposure age of surface rocks and monitor the secular equilibrium of 36Cl of sedimentary and igneous rock in groundwater. Due to the uncertainty effects of different chemical separation processes for removing 36S, there is a high degree of uncertainty in 36Cl accelerator mass spectrometry （AMS） measurements if the ratio of 36Cl/Cl is lower than 10-14. A 36Cl1 AMS higher sensitivity measurement has been set up by using a AE-Q3D method at the China Institute of Atomic Energy （CIAE）. The performances of AE-Q3D method for 36Cl-AMS measurement had been systemically studied. The experimental results show that the AE-Q3D method has a higher isobar suppression factor. Taking advantage of direct removing 36S, the sample preparation can be simplified and the uncertainty effects of different chemical separation processes can be reduced in 36Cl AMS measurements.展开更多
A semi-length focal plane detecting system for heavy ions has been built onthe Beijing Q3D magnetic spectrometer and tested by <sup>12</sup>C+<sup>197</sup>Au,<sup>16</sup>O+<sup...A semi-length focal plane detecting system for heavy ions has been built onthe Beijing Q3D magnetic spectrometer and tested by <sup>12</sup>C+<sup>197</sup>Au,<sup>16</sup>O+<sup>150</sup>Sm,and <sup>18</sup>O-<sup>156</sup>Gd reactions.The intrinsic resolutions of position and angle were 1.1 mmand 0.8°,respectively.The resolutions of energy loss ΔE,residual energy E<sub>R</sub> and totalenergy E<sub>T</sub> obtained were 3.0%,1.4% and 0.9%.respectively,after a special method ofdata processing was adopted.The achievable mass resolution is estimated to be about1.0% after necessary corrections for some signals concerned.Discussion aboul the edgeeffect of the detectors of this type is given too.展开更多
目的 根据人用药品技术要求国际协调理事会(International Council for Harmonisation of Technical Requirements forPharmaceuticals for Human Use,ICH) Q3D最新要求,建立同时测定利伐沙班中金属催化剂及控制元素杂质的分析方法。方...目的 根据人用药品技术要求国际协调理事会(International Council for Harmonisation of Technical Requirements forPharmaceuticals for Human Use,ICH) Q3D最新要求,建立同时测定利伐沙班中金属催化剂及控制元素杂质的分析方法。方法 应用微波消解-电感耦合等离子体-质谱法(microwave digestion-inductively coupled plasma-mass spectrometry,MD-ICP-MS),通过系列实验建立简便、快速的微波消解样品前处理方法,采用2 mL 15.1 mol·L^(-1)硝酸的微波消解体系,无需预消解,样品经消解后无需赶酸,直接定容即可进ICP-MS分析,无基质干扰。以钪(Sc)、铟(In)、锗(Ge)、铋(Bi)为内标,等离子功率1 549 W,载气流量1.08 L·min^(-1)。结果 8种元素杂质线性均良好(r均>0.999),检测限为0.001~0.059 ng·mL^(-1),各浓度点平均回收率为80%-100%(n=3),仪器精密度均<2%(n=6)。不同厂家的利伐沙班中金属催化剂及ICH控制元素杂质含量均符合ICH要求。结论 该方法速度快、干扰少、灵敏度高,可实现利伐沙班中元素杂质的准确定量测定,并简化了微波消解样品前处理方法,提高了检验效率,节省了检验成本,可推广应用到相似性质类别药品的微波消解样品前处理。展开更多
基金supported by National Natural Science Foundation of China (No. 10875176)
文摘The ratio of 36Cl/Cl can determine the exposure age of surface rocks and monitor the secular equilibrium of 36Cl of sedimentary and igneous rock in groundwater. Due to the uncertainty effects of different chemical separation processes for removing 36S, there is a high degree of uncertainty in 36Cl accelerator mass spectrometry （AMS） measurements if the ratio of 36Cl/Cl is lower than 10-14. A 36Cl1 AMS higher sensitivity measurement has been set up by using a AE-Q3D method at the China Institute of Atomic Energy （CIAE）. The performances of AE-Q3D method for 36Cl-AMS measurement had been systemically studied. The experimental results show that the AE-Q3D method has a higher isobar suppression factor. Taking advantage of direct removing 36S, the sample preparation can be simplified and the uncertainty effects of different chemical separation processes can be reduced in 36Cl AMS measurements.
文摘A semi-length focal plane detecting system for heavy ions has been built onthe Beijing Q3D magnetic spectrometer and tested by <sup>12</sup>C+<sup>197</sup>Au,<sup>16</sup>O+<sup>150</sup>Sm,and <sup>18</sup>O-<sup>156</sup>Gd reactions.The intrinsic resolutions of position and angle were 1.1 mmand 0.8°,respectively.The resolutions of energy loss ΔE,residual energy E<sub>R</sub> and totalenergy E<sub>T</sub> obtained were 3.0%,1.4% and 0.9%.respectively,after a special method ofdata processing was adopted.The achievable mass resolution is estimated to be about1.0% after necessary corrections for some signals concerned.Discussion aboul the edgeeffect of the detectors of this type is given too.
文摘目的 根据人用药品技术要求国际协调理事会(International Council for Harmonisation of Technical Requirements forPharmaceuticals for Human Use,ICH) Q3D最新要求,建立同时测定利伐沙班中金属催化剂及控制元素杂质的分析方法。方法 应用微波消解-电感耦合等离子体-质谱法(microwave digestion-inductively coupled plasma-mass spectrometry,MD-ICP-MS),通过系列实验建立简便、快速的微波消解样品前处理方法,采用2 mL 15.1 mol·L^(-1)硝酸的微波消解体系,无需预消解,样品经消解后无需赶酸,直接定容即可进ICP-MS分析,无基质干扰。以钪(Sc)、铟(In)、锗(Ge)、铋(Bi)为内标,等离子功率1 549 W,载气流量1.08 L·min^(-1)。结果 8种元素杂质线性均良好(r均>0.999),检测限为0.001~0.059 ng·mL^(-1),各浓度点平均回收率为80%-100%(n=3),仪器精密度均<2%(n=6)。不同厂家的利伐沙班中金属催化剂及ICH控制元素杂质含量均符合ICH要求。结论 该方法速度快、干扰少、灵敏度高,可实现利伐沙班中元素杂质的准确定量测定,并简化了微波消解样品前处理方法,提高了检验效率,节省了检验成本,可推广应用到相似性质类别药品的微波消解样品前处理。
