The pulsed-spray fluid-bed granulation (PSFBG) process was investigated and optimized using definitive scree ning design, a recently proposed new class of three-level desig n of experiment method. Such a design enable...The pulsed-spray fluid-bed granulation (PSFBG) process was investigated and optimized using definitive scree ning design, a recently proposed new class of three-level desig n of experiment method. Such a design enabled quadratic models to be established that described the effect of six in put process parameters - inlet air temperature, inlet air humidity, binder spray rate, atomization pressure, pulse period, and pulse width - on the granule quality in a PSFBG process. Mathematical models of the mean particle size, relative size distribution width, production yield, and porosity were developed to quantify the relationships between the in flue ncing factors and critical quality attributes. On the basis of con strai nts on the desired granule properties, a design space for PSFBG was determined and ranges of the operating parameters were defined. An acceptable degree of prediction was confirmed by validation experiments, demonstrating the reliability and effectiveness of using definitive screening design to study the PSFBG process. This method can accelerate screening and optimization of this process within a large multidimensional design space.展开更多
Pulsed spray is a useful tool forgranule size control in fluid bed granulation.To improve the quality control of pulsed-spray fluid bed granulation,a combination of in-line near-infrared(NIR)spectroscopy and p「incipa...Pulsed spray is a useful tool forgranule size control in fluid bed granulation.To improve the quality control of pulsed-spray fluid bed granulation,a combination of in-line near-infrared(NIR)spectroscopy and p「incipal component analysis was used to develop multivariate statistical process control(MSPC)charts.Different types of MSPC charts were developed,including principal component score charts,Hotelling's T2 control charts,and distance to model X control charts,to monitor the batch evolution throughout the granulation process.Correlation optimized warping was used as an alignment method to deal with the time variation in batches caused by the granulation mechanism in MSPC modeling.The control charts developed in this study were validated on normal batches and tested on four batches that deviated from normal processing conditions to achieve real-time fault analysis.The results indicated that the NIR spectroscopy-based MSPC model included the variability in the sample set constituting the model and could withstand external variability.This research demonstrated the application of synchronized NIR spectra in conjunction w让h multivariate batch modeling as an attractive tool for process monitoring and a fault diagnosis method for effective process control in pulsed-spray fluid bed granulation.展开更多
文摘The pulsed-spray fluid-bed granulation (PSFBG) process was investigated and optimized using definitive scree ning design, a recently proposed new class of three-level desig n of experiment method. Such a design enabled quadratic models to be established that described the effect of six in put process parameters - inlet air temperature, inlet air humidity, binder spray rate, atomization pressure, pulse period, and pulse width - on the granule quality in a PSFBG process. Mathematical models of the mean particle size, relative size distribution width, production yield, and porosity were developed to quantify the relationships between the in flue ncing factors and critical quality attributes. On the basis of con strai nts on the desired granule properties, a design space for PSFBG was determined and ranges of the operating parameters were defined. An acceptable degree of prediction was confirmed by validation experiments, demonstrating the reliability and effectiveness of using definitive screening design to study the PSFBG process. This method can accelerate screening and optimization of this process within a large multidimensional design space.
基金the National Science and Technology Major Project(grant number 2018ZX09201011-002).
文摘Pulsed spray is a useful tool forgranule size control in fluid bed granulation.To improve the quality control of pulsed-spray fluid bed granulation,a combination of in-line near-infrared(NIR)spectroscopy and p「incipal component analysis was used to develop multivariate statistical process control(MSPC)charts.Different types of MSPC charts were developed,including principal component score charts,Hotelling's T2 control charts,and distance to model X control charts,to monitor the batch evolution throughout the granulation process.Correlation optimized warping was used as an alignment method to deal with the time variation in batches caused by the granulation mechanism in MSPC modeling.The control charts developed in this study were validated on normal batches and tested on four batches that deviated from normal processing conditions to achieve real-time fault analysis.The results indicated that the NIR spectroscopy-based MSPC model included the variability in the sample set constituting the model and could withstand external variability.This research demonstrated the application of synchronized NIR spectra in conjunction w让h multivariate batch modeling as an attractive tool for process monitoring and a fault diagnosis method for effective process control in pulsed-spray fluid bed granulation.
