Objective: To observe the clinical therapeutic effect of acupuncture plus intensive pulse light irradiation on chloasma. Methods: Ninety-six cases of chloasma were randomly divided into two groups, the control group o...Objective: To observe the clinical therapeutic effect of acupuncture plus intensive pulse light irradiation on chloasma. Methods: Ninety-six cases of chloasma were randomly divided into two groups, the control group of 46 cases treated by simple acupuncture and the treatment group of 50 cases treated by acupuncture and intensive pulse light irradiation. Results: The total effective rate was 89.1% and 98.0% in the control group and treatment group respectively, with a significant difference between the two groups (P<0.05). Conclusion: For chloasma, the effect of treatment with acupuncture plus intensive pulse light irradiation is superior to that with simple acupuncture.展开更多
The aim of this study was to evaluate the factors influencing the inactivation effect of intense pulsed light(IPL)on Aeromonas salmonicida grown on chicken meat and skin,and to further develop prediction models of ina...The aim of this study was to evaluate the factors influencing the inactivation effect of intense pulsed light(IPL)on Aeromonas salmonicida grown on chicken meat and skin,and to further develop prediction models of inactivation.In this work,chicken meat and skin inoculated with meat-borne A.salmonicida isolates were subjected to IPL treatments under different conditions.The results showed that IPL had obvious bactericidal effect in the chicken skin and thickness groups when the treatment voltage and time were 7 V combined with 5 s.In addition,the lethality curves of A.salmonicida were fitted under IPL conditions of 3.5-7.5 V.The comparison of statistical parameters revealed that the Weibull model could best fit the mortality curves and could accurately predict the mortality dynamic of A.salmonicida grown on chicken skin.And further a secondary model between the scale factor b and the treatment voltage in Weibull model was established using linear equations,which determined that the secondary model could accurately predict the inactivation of A.salmonicida.This study provides a theoretical basis for future prediction models of Aeromonas,and also provides new ideas for sterilization approaches of meat-borne Aeromonas.展开更多
AIM:To investigate the efficacy and mechanisms of indirect intense pulsed light(IPL)irradiation on meibomian gland dysfunction(MGD).METHODS:A total of 60 MGD patients was included in this prospective randomized contro...AIM:To investigate the efficacy and mechanisms of indirect intense pulsed light(IPL)irradiation on meibomian gland dysfunction(MGD).METHODS:A total of 60 MGD patients was included in this prospective randomized controlled trial.Patients were randomly assigned 1:1 into two groups(3-mm group and 10-mm group)in which IPL was applied at distances from the lower eyelid margin of 3 and 10 mm,respectively.Both groups received three times treatment with 3-week interval.Meibomian gland yield secretion score(MGYSS),standard patient evaluation of eye dryness(SPEED)questionnaire,tear break-up time(TBUT),corneal fluorescein staining(CFS),and in vivo confocal microscopy were performed at baseline and after every treatment.RESULTS:After three IPL treatments,both groups had significant improvement in MGYSS(both P<0.05).The noninferiority test showed that improvement in 10-mm group was not inferior to that in 3-mm group(P<0.001).In both groups,temporal regions of both upper and lower eyelids showed significant improvement in MGYSS.Scores of SPEED questionnaire in both groups declined significantly(both P<0.001)and changes of SPEED had no difference between two groups(P=0.57).Density of central corneal subepithelial nerves and TBUTs showed no statistically significant changes.The 3-mm group had improvement on corneal fluorescein staining(P=0.048)and meibomian gland morphology(acini wall thickness P=0.003,hyperreflective points P=0.024)while the 10-mm group had not.CONCLUSION:The efficacy of IPL indirect irradiation in improving meibomian gland secretion and alleviating dry eye symptoms remains unchanged with increase in treatment distance.IPL may primarily act on the functional improvement of the meibomian glands and corneal nerves.展开更多
Objective To evaluate the effect of intense pulsed light(IPL)in the treatment of chronic hordeolum.Methods Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study.According to the sever...Objective To evaluate the effect of intense pulsed light(IPL)in the treatment of chronic hordeolum.Methods Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study.According to the severity of hordeolum,the patients were treated with IPL 3 to 5 times.Patients’satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were collected.The number,congestion,long diameter,short diameter and area of nodules were also recorded and measured.Finally,eyelid margin signs,meibum quality,meibomian gland expressibility,meibomian gland dropout,tear meniscus height,and corneal fluorescein staining were scored.Results 20 patients were enrolled in this study.The eyelid margins were congestive and swollen,with blunt rounding or irregularity.The meibum was cloudy or toothpaste-like.The meibomian gland expressibility,meibomian gland dropout and tear meniscus height were reduced.The cornea showed scattered fluorescein staining.After treatment,score of visual analog scale,congestion and size of nodules were significantly reduced.Eyelid margin signs,meibum quality,meibomian gland expressibility,tear meniscus height and corneal fluorescein staining scores were improved.Meibomian gland dropout had no significant change.No side effects occurred during treatment.Conclusions IPL is beneficial for the treatment of chronic hordeolum.展开更多
Rosacea presents as transient or persistent erythema,papules,pustules,fAushing,and telangi-ectasia on the middle of the face,which has some clinical similarity with act inic keratosis(AK).These two conditions can coex...Rosacea presents as transient or persistent erythema,papules,pustules,fAushing,and telangi-ectasia on the middle of the face,which has some clinical similarity with act inic keratosis(AK).These two conditions can coexist in the same patient.Dermoscopy and reflect ance confocal microscopy(RCM)could be useful methods for diagnosis and monitoring treatment efficacy.Novel intense pulsed light-photodynamic therapy(IPL-PDT)may have better tolerance and curative effect than traditional red-light 5-aminolevulinic acid photodynamic therapy(ALA-PDT).Herein,we present a case of facial AKs concomitant with rosacea where combination therapy of novel IPL-PDT and oral minocycline was effective in that AK lesions were eliminated and the patient's facial erythema and telangiectasia were significantly improved.展开更多
Although perovskite solar cells(PSCs)have achieved a high power conversion efficiency(PCE)within a short period of development,the high-temperature sintering of the constituent electron-selective layers(ESLs)impedes t...Although perovskite solar cells(PSCs)have achieved a high power conversion efficiency(PCE)within a short period of development,the high-temperature sintering of the constituent electron-selective layers(ESLs)impedes the commercialization.In this report,we demonstrate the effectiveness of an intensepulsed-light(IPL)treatment for the rapid and damage-free sintering of amorphous-SnO_(2)ESLs for use in PSCs.The IPL treatment of amorphous-SnO_(2)substantially reduced the amount of surface hydroxyl groups,modified the surface energy,and enabled the growth of a low-stress perovskite layer with large grain sizes,all of which enhanced the photovoltaic properties and led to the proper alignment of band structures for efficient PSCs.Through comprehensive optimization of the IPL conditions,a PCE of 17.68%was achieved from the MAPb I3 planar PSC based on an amorphous-SnO_(2)IPL treated for a few tens of seconds,which was significantly increased compared with a PCE(7.06%)of nontreated SnO_(2)based counterpart.In addition,the PCE of the IPL-treated SnO_(2)based PSC is comparable to the best PCE(18.16%)of PSCs fabricated with SnO_(2)ESL annealed for three hours at 185℃.Because of its ultrafast sintering time and tendency to not damage SnO_(2)ESLs,the new IPL process is expected to open new opportunities for the commercialization of PSCs.展开更多
In this paper, we theoretically discuss the soliton properties of light pulse transportation on the surface of an ionic crystal having strong nonlinear interactions between ions of unit cells. We analyze in detail the...In this paper, we theoretically discuss the soliton properties of light pulse transportation on the surface of an ionic crystal having strong nonlinear interactions between ions of unit cells. We analyze in detail the dark solitons when the nonlinear coefficient g is positive and negative, respectively. It is found that whether the nonlinear coefficient g is positive or negative, the dark solitons can be formed over the whole dispersion relation area of surface polaritons considering nonlinear effects. Attention should be paid to the fact that around , the light pulse can form advanced dark solitons, and there is a switching area from advanced dark soliton to retarded dark soliton near . We also discuss the effects of higher nonlinear dispersion on the solitons.展开更多
The phase time of p-polarized light pulses passing through a glass plate is investigated. We do this by converting the problem into a l-dimensional quantum-mechanical counterpart, a potential well with a position-depe...The phase time of p-polarized light pulses passing through a glass plate is investigated. We do this by converting the problem into a l-dimensional quantum-mechanical counterpart, a potential well with a position-dependent effective mass. We find that the phase time and the lateral shift have the negative characteristics.展开更多
We experimentally study the generation and storage of double slow light pulses in a pr^3＋：Y2SiO5 crystal. Under electromagnetically induced transparency, a single signal pulse is stored in the spin coherence of the ...We experimentally study the generation and storage of double slow light pulses in a pr^3＋：Y2SiO5 crystal. Under electromagnetically induced transparency, a single signal pulse is stored in the spin coherence of the crystal. By simultaneously switching on two control fields to recall the stored information, the spin coherence is converted into two slow light pulses with distinct frequencies. Furthermore, the storage and controlled retrieval of double slow light pulses are obtained by manipulating the control fields. This study of double slow light pulses may have practical applications in information processing and all-optical networks.展开更多
Objective: to observe the efficacy of intense pulsed light (IPL) in the treatment of refractory Demodex blepharitis. Methods: a prospective study was conducted to collect 15 patients with Demodex blepharitis diagnosed...Objective: to observe the efficacy of intense pulsed light (IPL) in the treatment of refractory Demodex blepharitis. Methods: a prospective study was conducted to collect 15 patients with Demodex blepharitis diagnosed in Zigong first people's Hospital from September 2020 to may 2021 and ineffective after treatment with tea tree essential oil for 3 months. They were treated with IPL for 4 times (the first 3 times, with an interval of 2 weeks, and the last time with an interval of 4 weeks). The symptoms and symptoms of patients before and after treatment (2 weeks, 4 weeks, 8 weeks and 12 weeks) were observed changes in the total amount of Demodex and the number of Demodex in different stages. Results: during the 3-month follow-up period, the symptom score and the number of Demodex decreased significantly. Before treatment, at 2 weeks, 4 weeks, 8 weeks and 12 weeks after treatment, the symptom scores were 9.69 ± 2.06, 9.08 ± 2.02, 7.85 ± 2.34, 3.69 ± 2.84 and 3.23 ± 3.19 respectively. The symptoms improved from the 8th week, and the difference was statistically significant compared with that before treatment (P < 0.05);The total amount of Demodex was 17 (11.5, 26.25), 13.5 (11, 18.75), 11.5 (8.5, 16.75), 7 (5.25, 11.25) and 6 (1.75, 7.75) respectively. From the 8th week, the total amount of Demodex was lower than that before treatment (P < 0.05). The number of Demodex decreased mainly in adults (P < 0.05), but there was no significant difference in the number of eggs and larvae (P ≥ 0.05). Conclusion: IPL is an effective method for the treatment of refractory Demodex blepharitis.展开更多
This thesis puts forward a conjecture that, owing to some unknown special character of light, it is impossible to determine whether the speed of light is variable by the interference method. To verify the hypothesis ...This thesis puts forward a conjecture that, owing to some unknown special character of light, it is impossible to determine whether the speed of light is variable by the interference method. To verify the hypothesis of the invariance of light speed, a new method must be found to take accurate measurement of the infinitesimal change in the travelling time of light. The thesis suggests the adoption of high frequency laser pulse technology to carry out the measurement. On the basis of this idea a new discriminating experiment is proposed to test the hypothesis of the invariance of light speed. The thesis also makes some forecast of the future prospects of this experiment and of the future development of the theory of special relativity.展开更多
We present a novel mechanism,which is formed by periodically changing the radii of dielectric rods in the middle row of a photonic crystal, to control and stop light. Using the Bloch theory and coupled-mode theoryl th...We present a novel mechanism,which is formed by periodically changing the radii of dielectric rods in the middle row of a photonic crystal, to control and stop light. Using the Bloch theory and coupled-mode theoryl the dispersion characteristic of such a photonic crystal coupled cavity optical waveguide is obtained. We also theoretically demonstrate that the group velocity of a light pulse in this system can be modulated by dynamically changing the refractive index or radii of the selected dielectric rods, and the light stopping can be achieved.展开更多
Objective:To develop and optimize intense pulsed light(IPL)technology for the treatment of blepharitis-associated dry eye disease and to evaluate its biomedical effects on meibomian gland function and corneal epitheli...Objective:To develop and optimize intense pulsed light(IPL)technology for the treatment of blepharitis-associated dry eye disease and to evaluate its biomedical effects on meibomian gland function and corneal epithelial repair.Methods:The affected eyes of 90 patients with blepharitis-associated dry eye disease admitted to our hospital were selected,and the optimal parameters of enhanced pulsed light technology for dry eye syndrome were selected by L_(9)(3^(4))orthogonal experimental design with pulse width,pulse delay and energy gradient as the influencing factors,and the meibomian gland function was used as the evaluation index.The effect on meibomian gland f unction and corneal epithelial repair in patients with dry eye inflammation of the palpebral margin was observed.Results:The analysis of variance(ANOVA)results for the response surface methodology experiment demonstrated that the established model(R1=+0.92+0.38×energy gradient-0.33×pulse duration-0.10×pulse delay+0.65×energy gradient×pulse duration+1.30×energy gradient×pulse delay+0.100×pulse duration×pulse delay+1.37×energy gradient^(2)+0.065×pulse duration^(2)-0.58×pulse delay^(2))showed statistical significance(P<0.05),and the lack-of-fit term was non-significant(P>0.05),indicating that high reliability and successful modeling.The optimal parameters of the three factors appeared in the energy gradient pulse width of 14 J,10.82 ms,and pulse delay of 40.14 ms.After optimization with reference to the above parameters,the difference in meibomian gland function grade in 45 patients was significantly higher than that of the patients before optimization(P<0.05).Conclusion:The optimized IPL technology demonstrotes a significant improvement in blepharitis-associated dry eye disease,which can improve meibomian gland function,but still cannot promote corneal epithelial repair,so other treatment regimens can be considered.展开更多
Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients worldwide.The current study was aimed at evaluating the potential clinical benefit...Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients worldwide.The current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments.To our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of patients.Methods:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye symptomatology.All patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis setting.Changes in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after treatment.Results:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after treatment.Conclusions:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments,with an additional improvement in clinical signs,such as tear osmolarity and corneal staining.展开更多
Generating Bessel-Gauss beams in the extreme ultraviolet(EUV)with attosecond pulse durations poses a significant challenge due to the limitations of conventional transmission optical components.Here,we propose a novel...Generating Bessel-Gauss beams in the extreme ultraviolet(EUV)with attosecond pulse durations poses a significant challenge due to the limitations of conventional transmission optical components.Here,we propose a novel approach to produce such beams by inducing an annular EUV source through high-order harmonic generation(HHG)under nonadiabatic phase-matching conditions.The resulting light pulse maintains temporal coherence and manifests attosecond pulse trains as confirmed by the reconstruction of attosecond beating by interference of two-photon transitions(RABBIT)measurements.Macroscopic HHG calculations reproduce the measured spatiotemporal structures,demonstrating the plasma-induced spatial modulation on the formation of an annular source.Propagation simulations further confirm the feasibility of this approach for generating attosecond Bessel-Gauss beams,presenting exciting prospects for various applications in EUV photonics and attosecond science.展开更多
The meibomian gland is a unique sebaceous gland located in the eyelid.Its main function is to secrete lipids and form the lipid layer of the tear film to delay the evaporation of waterborne tears,increase the surface ...The meibomian gland is a unique sebaceous gland located in the eyelid.Its main function is to secrete lipids and form the lipid layer of the tear film to delay the evaporation of waterborne tears,increase the surface tension of the tear film,and to lubricate the contact area of the eyelid and eyeball.Abnormal secretion of the meibomian gland is known as meibomian gland dysfunction(MGD),which has become the most important cause of evaporative dry eye disease(DED).The clinical pathophysiological process and underlying molecular mechanisms of MGD are not clear.As serious side effects may occur with the long-term use of hormonotherapy and non-steroidal anti-inflammatory drugs(NSAIDs)for the treatment of MGD,meibomian gland physiotherapy is considered the most effective and safest therapy for MGD.This review summarizes the physical therapy modalities of western medicine(WM)and traditiond Chinese medicine(TCM)for the treatment of MGD to provide optimal treatments for these patients and to further lay a foundation for mechanistic studies of MGD.展开更多
Attosecond light pulses have revolutionized the study of electron dynamics in materials by enabling the observation of ultrafast processes with unprecedented attosecond temporal resolution.They are primarily generated...Attosecond light pulses have revolutionized the study of electron dynamics in materials by enabling the observation of ultrafast processes with unprecedented attosecond temporal resolution.They are primarily generated through the process of high-order harmonic generation.This paper presents a comprehensive setup for attosecond pulse generation and measurement.Using a 900 nm,7 mJ,and 7 fs femtosecond laser with stabilized carrier-envelope phase,we employ polarization gating to generate a near single-cycle,linearly polarized pulse that interacts with neon gas to produce a broadband extreme-ultraviolet continuum with a cutoff photon energy of∼120 eV.The temporal and spectral characteristics of the generated single attosecond pulses are measured using an attosecond streak camera,and the pulse duration is determined to be 59 as through the frequency-resolved optical gating for complete reconstruction of attosecond bursts retrieval algorithm.As part of the Synergetic Extreme Condition User Facility,this setup will facilitate ultrafast research in transient absorption and photoelectron spectroscopy,providing global users with a powerful tool for studying electron dynamics in various materials.展开更多
Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma,which affects tens of millions of people worldwide every year.Traumatic scars diminish the quality of life...Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma,which affects tens of millions of people worldwide every year.Traumatic scars diminish the quality of life due to disfigurement,symptoms of pain and itch,and restricted motion.The pathogenesis and pathophysiology of traumatic scar remain elusive.The management for traumatic scars is comprised of surgical and non-surgical interventions such as pressure therapy,silicone,corticosteroid,and radiotherapy,which are chosen by clinicians based on the physical examinations of scars.Recently,great progress in treating traumatic scars has been achieved by the development of novel technologies including laser,intense pulsed light(IPL),radiofrequency,and ultrasound.The aim of this review article was to summarize the advances of these technologies for traumatic scars intervention.展开更多
The demand for processed foods and the awareness about food quality and safety are increasing rapidly.The consumers’demand for minimally processed foods and growing competition in the market have made the processors ...The demand for processed foods and the awareness about food quality and safety are increasing rapidly.The consumers’demand for minimally processed foods and growing competition in the market have made the processors to adopt newer non-thermal technologies that preserve nutrients and sensory properties of the products.Conventionally,heat processing of foods is carried out to convert raw material into value-added product,reduce or eliminate microbial load to improve safety,and extend shelf life.Some of the limitations of thermal processing techniques can be overcome by employing non-thermal processes.High hydrostatic pressure,pulsed electric field,ultrasound,cold plasma,dense phase carbon dioxide,ozone,and pulsed light(PL)processing are gaining popularity in food processing.PL technology is a non-thermal technology,where sterilization and decontamination are achieved by impinging high-intensity light pulses of short durations on surfaces of foods and high-transmission liquids.Although a few reports on the PL technology are available,in-depth studies on this are needed to adopt at a commercial level.The present review provides an overview of light-based processing of foods and covers important aspects such as different PL systems used for processing of foods,mode of action of PL on microbes,the effect of PL on liquid foods,surface decontamination of foods and parameters that affect PL efficacy,combination processing with PL.With the growing demand in non-thermal processing for the technological advancement in the area of generation of light,light-based processing will be a promising technology for microbial load reduction.展开更多
Objective We investigated the efficacy and safety of 1064 nm Nd： YAG laser, intense pulsed light （IPL）, and lauromacrogol injection in the treatment of hemangioma, in order to evaluate the value of color Doppler u...Objective We investigated the efficacy and safety of 1064 nm Nd： YAG laser, intense pulsed light （IPL）, and lauromacrogol injection in the treatment of hemangioma, in order to evaluate the value of color Doppler ultrasound guidance in choosing the optimal treatment modality. Methods Infantile patients who were clinical diagnosed as hemangiomas were randomly divided into group A, who had color Doppler ultrasound examinations before the treatment, and group B who had the treatment without ultrasound evaluation. Patients in the group A were assigned into subgroups according to the depth of lesion by sonography： group A-1 for those who had a lesion depth 〈1.2 mm, and took intense pulsed light therapy; group A-2 for those who had a lesion depth ≥1.2mm and 〈 3 mm, and took long pulse 1064 nm Nd：YAG laser therapy; group A-3 for those who had a lesion depth ≥3mm and 〈5 mm, and were treated by IPL combined with long pulse 1064 nm Nd：YAG laser treatment; Group A-4 for those who had a lesion depth ≥5 mm, and took lauromacrogol injection therapy. Patients in the group B took long pulse 1064 nm Nd：YAG laser treatment without preoperative ultrasound evaluation. The efficacy and adverse reactions of the treatments between the groups were evaluated and compared statistically. Results Totally 113 patients with 128 skin lesions were enrolled in this study, 85 in the group A （mean age 6.8±7.9 months） and 28 in the group B （mean age 6.9±9.9 months）. The mean depth of hemangioma was 3.3±1.1 mm in the group A, ranging from 0.5-7.8 mm, with 0.8±0.4 mm, 2.2±0.4 mm, 4.2±0.6 mm and 6.2±0.7 mm in group A1, A2, A3 and A4, respectively. The cure rates and effective rates in the group A were significantly higher than those in the group B （cure rates： 64.5% vs 56.3%, U=3.378, P=0.045; effective rates： 89.5% vs 78.1%, U=4.163, P=0.041）. The adverse effect rates of the group A （vesicle 20.0%, pigmentation 46.9%, scarring 17.7%） were lower than those of the group B （vesicle 21.9%, pigmentation 60.4%, scarring 25.0%）. Incidences of pigmentation and scarring were statistically significantly different （U=3.884, P=0.034, and U=4.016, P=0.032 respectively） between the two groups. Conclusion With the guidance of color Doppler ultrasound, the efficacy and safety of long pulse 1064 nmNd：YAG laser, intense pulsed light, and lauromacrogol injection in the treatment of infantile hemangioma have better outcomes compared to laser treatment alone without preoperative ultrasound examination.展开更多
文摘Objective: To observe the clinical therapeutic effect of acupuncture plus intensive pulse light irradiation on chloasma. Methods: Ninety-six cases of chloasma were randomly divided into two groups, the control group of 46 cases treated by simple acupuncture and the treatment group of 50 cases treated by acupuncture and intensive pulse light irradiation. Results: The total effective rate was 89.1% and 98.0% in the control group and treatment group respectively, with a significant difference between the two groups (P<0.05). Conclusion: For chloasma, the effect of treatment with acupuncture plus intensive pulse light irradiation is superior to that with simple acupuncture.
基金supported by projects funded by grants from the Natural Science Foundation of Jiangsu Province in China(BK20221515)the National Natural Science Foundation of China(32172266)the Changzhou Science and Technology Support Program(CE20222002)。
文摘The aim of this study was to evaluate the factors influencing the inactivation effect of intense pulsed light(IPL)on Aeromonas salmonicida grown on chicken meat and skin,and to further develop prediction models of inactivation.In this work,chicken meat and skin inoculated with meat-borne A.salmonicida isolates were subjected to IPL treatments under different conditions.The results showed that IPL had obvious bactericidal effect in the chicken skin and thickness groups when the treatment voltage and time were 7 V combined with 5 s.In addition,the lethality curves of A.salmonicida were fitted under IPL conditions of 3.5-7.5 V.The comparison of statistical parameters revealed that the Weibull model could best fit the mortality curves and could accurately predict the mortality dynamic of A.salmonicida grown on chicken skin.And further a secondary model between the scale factor b and the treatment voltage in Weibull model was established using linear equations,which determined that the secondary model could accurately predict the inactivation of A.salmonicida.This study provides a theoretical basis for future prediction models of Aeromonas,and also provides new ideas for sterilization approaches of meat-borne Aeromonas.
基金Supported by the National Natural Science Foundation of China(No.81870629).
文摘AIM:To investigate the efficacy and mechanisms of indirect intense pulsed light(IPL)irradiation on meibomian gland dysfunction(MGD).METHODS:A total of 60 MGD patients was included in this prospective randomized controlled trial.Patients were randomly assigned 1:1 into two groups(3-mm group and 10-mm group)in which IPL was applied at distances from the lower eyelid margin of 3 and 10 mm,respectively.Both groups received three times treatment with 3-week interval.Meibomian gland yield secretion score(MGYSS),standard patient evaluation of eye dryness(SPEED)questionnaire,tear break-up time(TBUT),corneal fluorescein staining(CFS),and in vivo confocal microscopy were performed at baseline and after every treatment.RESULTS:After three IPL treatments,both groups had significant improvement in MGYSS(both P<0.05).The noninferiority test showed that improvement in 10-mm group was not inferior to that in 3-mm group(P<0.001).In both groups,temporal regions of both upper and lower eyelids showed significant improvement in MGYSS.Scores of SPEED questionnaire in both groups declined significantly(both P<0.001)and changes of SPEED had no difference between two groups(P=0.57).Density of central corneal subepithelial nerves and TBUTs showed no statistically significant changes.The 3-mm group had improvement on corneal fluorescein staining(P=0.048)and meibomian gland morphology(acini wall thickness P=0.003,hyperreflective points P=0.024)while the 10-mm group had not.CONCLUSION:The efficacy of IPL indirect irradiation in improving meibomian gland secretion and alleviating dry eye symptoms remains unchanged with increase in treatment distance.IPL may primarily act on the functional improvement of the meibomian glands and corneal nerves.
文摘Objective To evaluate the effect of intense pulsed light(IPL)in the treatment of chronic hordeolum.Methods Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study.According to the severity of hordeolum,the patients were treated with IPL 3 to 5 times.Patients’satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were collected.The number,congestion,long diameter,short diameter and area of nodules were also recorded and measured.Finally,eyelid margin signs,meibum quality,meibomian gland expressibility,meibomian gland dropout,tear meniscus height,and corneal fluorescein staining were scored.Results 20 patients were enrolled in this study.The eyelid margins were congestive and swollen,with blunt rounding or irregularity.The meibum was cloudy or toothpaste-like.The meibomian gland expressibility,meibomian gland dropout and tear meniscus height were reduced.The cornea showed scattered fluorescein staining.After treatment,score of visual analog scale,congestion and size of nodules were significantly reduced.Eyelid margin signs,meibum quality,meibomian gland expressibility,tear meniscus height and corneal fluorescein staining scores were improved.Meibomian gland dropout had no significant change.No side effects occurred during treatment.Conclusions IPL is beneficial for the treatment of chronic hordeolum.
基金This research was financially funded by the National Natural Science Foundation of Shanghai(22ZR1455400)Shanghai Rising-Star Program(20QA1408600)Shanghai Sailing Program(21YF1441600).
文摘Rosacea presents as transient or persistent erythema,papules,pustules,fAushing,and telangi-ectasia on the middle of the face,which has some clinical similarity with act inic keratosis(AK).These two conditions can coexist in the same patient.Dermoscopy and reflect ance confocal microscopy(RCM)could be useful methods for diagnosis and monitoring treatment efficacy.Novel intense pulsed light-photodynamic therapy(IPL-PDT)may have better tolerance and curative effect than traditional red-light 5-aminolevulinic acid photodynamic therapy(ALA-PDT).Herein,we present a case of facial AKs concomitant with rosacea where combination therapy of novel IPL-PDT and oral minocycline was effective in that AK lesions were eliminated and the patient's facial erythema and telangiectasia were significantly improved.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(2020R1F1A1068664)supported by the Defense Challengeable Future Technology Program of the Agency for Defense Development,Republic of Korea。
文摘Although perovskite solar cells(PSCs)have achieved a high power conversion efficiency(PCE)within a short period of development,the high-temperature sintering of the constituent electron-selective layers(ESLs)impedes the commercialization.In this report,we demonstrate the effectiveness of an intensepulsed-light(IPL)treatment for the rapid and damage-free sintering of amorphous-SnO_(2)ESLs for use in PSCs.The IPL treatment of amorphous-SnO_(2)substantially reduced the amount of surface hydroxyl groups,modified the surface energy,and enabled the growth of a low-stress perovskite layer with large grain sizes,all of which enhanced the photovoltaic properties and led to the proper alignment of band structures for efficient PSCs.Through comprehensive optimization of the IPL conditions,a PCE of 17.68%was achieved from the MAPb I3 planar PSC based on an amorphous-SnO_(2)IPL treated for a few tens of seconds,which was significantly increased compared with a PCE(7.06%)of nontreated SnO_(2)based counterpart.In addition,the PCE of the IPL-treated SnO_(2)based PSC is comparable to the best PCE(18.16%)of PSCs fabricated with SnO_(2)ESL annealed for three hours at 185℃.Because of its ultrafast sintering time and tendency to not damage SnO_(2)ESLs,the new IPL process is expected to open new opportunities for the commercialization of PSCs.
文摘In this paper, we theoretically discuss the soliton properties of light pulse transportation on the surface of an ionic crystal having strong nonlinear interactions between ions of unit cells. We analyze in detail the dark solitons when the nonlinear coefficient g is positive and negative, respectively. It is found that whether the nonlinear coefficient g is positive or negative, the dark solitons can be formed over the whole dispersion relation area of surface polaritons considering nonlinear effects. Attention should be paid to the fact that around , the light pulse can form advanced dark solitons, and there is a switching area from advanced dark soliton to retarded dark soliton near . We also discuss the effects of higher nonlinear dispersion on the solitons.
文摘The phase time of p-polarized light pulses passing through a glass plate is investigated. We do this by converting the problem into a l-dimensional quantum-mechanical counterpart, a potential well with a position-dependent effective mass. We find that the phase time and the lateral shift have the negative characteristics.
基金supported by the National Basic Research Program of China (Grant No.2011CB921603)the National Natural Science Foundation of China (Grant Nos.11074097,10904048,10974071,11004079,and 11004080)+1 种基金the Basic Research Program of Jilin Universitythe China Postdoctoral Science Foundation (Grant No.2011M500924)
文摘We experimentally study the generation and storage of double slow light pulses in a pr^3＋：Y2SiO5 crystal. Under electromagnetically induced transparency, a single signal pulse is stored in the spin coherence of the crystal. By simultaneously switching on two control fields to recall the stored information, the spin coherence is converted into two slow light pulses with distinct frequencies. Furthermore, the storage and controlled retrieval of double slow light pulses are obtained by manipulating the control fields. This study of double slow light pulses may have practical applications in information processing and all-optical networks.
文摘Objective: to observe the efficacy of intense pulsed light (IPL) in the treatment of refractory Demodex blepharitis. Methods: a prospective study was conducted to collect 15 patients with Demodex blepharitis diagnosed in Zigong first people's Hospital from September 2020 to may 2021 and ineffective after treatment with tea tree essential oil for 3 months. They were treated with IPL for 4 times (the first 3 times, with an interval of 2 weeks, and the last time with an interval of 4 weeks). The symptoms and symptoms of patients before and after treatment (2 weeks, 4 weeks, 8 weeks and 12 weeks) were observed changes in the total amount of Demodex and the number of Demodex in different stages. Results: during the 3-month follow-up period, the symptom score and the number of Demodex decreased significantly. Before treatment, at 2 weeks, 4 weeks, 8 weeks and 12 weeks after treatment, the symptom scores were 9.69 ± 2.06, 9.08 ± 2.02, 7.85 ± 2.34, 3.69 ± 2.84 and 3.23 ± 3.19 respectively. The symptoms improved from the 8th week, and the difference was statistically significant compared with that before treatment (P < 0.05);The total amount of Demodex was 17 (11.5, 26.25), 13.5 (11, 18.75), 11.5 (8.5, 16.75), 7 (5.25, 11.25) and 6 (1.75, 7.75) respectively. From the 8th week, the total amount of Demodex was lower than that before treatment (P < 0.05). The number of Demodex decreased mainly in adults (P < 0.05), but there was no significant difference in the number of eggs and larvae (P ≥ 0.05). Conclusion: IPL is an effective method for the treatment of refractory Demodex blepharitis.
文摘This thesis puts forward a conjecture that, owing to some unknown special character of light, it is impossible to determine whether the speed of light is variable by the interference method. To verify the hypothesis of the invariance of light speed, a new method must be found to take accurate measurement of the infinitesimal change in the travelling time of light. The thesis suggests the adoption of high frequency laser pulse technology to carry out the measurement. On the basis of this idea a new discriminating experiment is proposed to test the hypothesis of the invariance of light speed. The thesis also makes some forecast of the future prospects of this experiment and of the future development of the theory of special relativity.
基金supported by the National Natural Science Foundation of China(No.10874128)
文摘We present a novel mechanism,which is formed by periodically changing the radii of dielectric rods in the middle row of a photonic crystal, to control and stop light. Using the Bloch theory and coupled-mode theoryl the dispersion characteristic of such a photonic crystal coupled cavity optical waveguide is obtained. We also theoretically demonstrate that the group velocity of a light pulse in this system can be modulated by dynamically changing the refractive index or radii of the selected dielectric rods, and the light stopping can be achieved.
文摘Objective:To develop and optimize intense pulsed light(IPL)technology for the treatment of blepharitis-associated dry eye disease and to evaluate its biomedical effects on meibomian gland function and corneal epithelial repair.Methods:The affected eyes of 90 patients with blepharitis-associated dry eye disease admitted to our hospital were selected,and the optimal parameters of enhanced pulsed light technology for dry eye syndrome were selected by L_(9)(3^(4))orthogonal experimental design with pulse width,pulse delay and energy gradient as the influencing factors,and the meibomian gland function was used as the evaluation index.The effect on meibomian gland f unction and corneal epithelial repair in patients with dry eye inflammation of the palpebral margin was observed.Results:The analysis of variance(ANOVA)results for the response surface methodology experiment demonstrated that the established model(R1=+0.92+0.38×energy gradient-0.33×pulse duration-0.10×pulse delay+0.65×energy gradient×pulse duration+1.30×energy gradient×pulse delay+0.100×pulse duration×pulse delay+1.37×energy gradient^(2)+0.065×pulse duration^(2)-0.58×pulse delay^(2))showed statistical significance(P<0.05),and the lack-of-fit term was non-significant(P>0.05),indicating that high reliability and successful modeling.The optimal parameters of the three factors appeared in the energy gradient pulse width of 14 J,10.82 ms,and pulse delay of 40.14 ms.After optimization with reference to the above parameters,the difference in meibomian gland function grade in 45 patients was significantly higher than that of the patients before optimization(P<0.05).Conclusion:The optimized IPL technology demonstrotes a significant improvement in blepharitis-associated dry eye disease,which can improve meibomian gland function,but still cannot promote corneal epithelial repair,so other treatment regimens can be considered.
文摘Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients worldwide.The current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments.To our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of patients.Methods:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye symptomatology.All patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis setting.Changes in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after treatment.Results:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after treatment.Conclusions:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments,with an additional improvement in clinical signs,such as tear osmolarity and corneal staining.
基金supported by National Natural Science Foundation of China(Grants Nos.12450402,12134005,92250306,11627807,and 12274230)the National Basic Research Program of China(No.2019YFA0307700)+1 种基金Funding of Nanjing University of Science and Technology(NJUST)(No.TSXK2022D005)the Fundamental Research Funds for the Central Universities.
文摘Generating Bessel-Gauss beams in the extreme ultraviolet(EUV)with attosecond pulse durations poses a significant challenge due to the limitations of conventional transmission optical components.Here,we propose a novel approach to produce such beams by inducing an annular EUV source through high-order harmonic generation(HHG)under nonadiabatic phase-matching conditions.The resulting light pulse maintains temporal coherence and manifests attosecond pulse trains as confirmed by the reconstruction of attosecond beating by interference of two-photon transitions(RABBIT)measurements.Macroscopic HHG calculations reproduce the measured spatiotemporal structures,demonstrating the plasma-induced spatial modulation on the formation of an annular source.Propagation simulations further confirm the feasibility of this approach for generating attosecond Bessel-Gauss beams,presenting exciting prospects for various applications in EUV photonics and attosecond science.
基金We thank for the funding support from the Research and Innovation Project of Graduate Students in Hunan Province(No.CX20190538)the First-class Open Fund for Integrated Chinese and Western Medicine(No.2018ZXYJH05)+1 种基金the Traditional Chinese Medicine First-Class Discipline Open Fund(No.2018ZYX57)the Construction Project of Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine(No.2018YGC02).
文摘The meibomian gland is a unique sebaceous gland located in the eyelid.Its main function is to secrete lipids and form the lipid layer of the tear film to delay the evaporation of waterborne tears,increase the surface tension of the tear film,and to lubricate the contact area of the eyelid and eyeball.Abnormal secretion of the meibomian gland is known as meibomian gland dysfunction(MGD),which has become the most important cause of evaporative dry eye disease(DED).The clinical pathophysiological process and underlying molecular mechanisms of MGD are not clear.As serious side effects may occur with the long-term use of hormonotherapy and non-steroidal anti-inflammatory drugs(NSAIDs)for the treatment of MGD,meibomian gland physiotherapy is considered the most effective and safest therapy for MGD.This review summarizes the physical therapy modalities of western medicine(WM)and traditiond Chinese medicine(TCM)for the treatment of MGD to provide optimal treatments for these patients and to further lay a foundation for mechanistic studies of MGD.
基金supported by the National Natural Science Foundation of China(Grant Nos.12174435,12034020,and 92250303)the Chinese Academy of Sciences Project for Young Scientists in Basic Research(Grant No.YSBR-091)the National Key R&D Program of China(Grant No.2022YFA1604200).
文摘Attosecond light pulses have revolutionized the study of electron dynamics in materials by enabling the observation of ultrafast processes with unprecedented attosecond temporal resolution.They are primarily generated through the process of high-order harmonic generation.This paper presents a comprehensive setup for attosecond pulse generation and measurement.Using a 900 nm,7 mJ,and 7 fs femtosecond laser with stabilized carrier-envelope phase,we employ polarization gating to generate a near single-cycle,linearly polarized pulse that interacts with neon gas to produce a broadband extreme-ultraviolet continuum with a cutoff photon energy of∼120 eV.The temporal and spectral characteristics of the generated single attosecond pulses are measured using an attosecond streak camera,and the pulse duration is determined to be 59 as through the frequency-resolved optical gating for complete reconstruction of attosecond bursts retrieval algorithm.As part of the Synergetic Extreme Condition User Facility,this setup will facilitate ultrafast research in transient absorption and photoelectron spectroscopy,providing global users with a powerful tool for studying electron dynamics in various materials.
基金supported by the National Natural Science Foundation of China(No.81772118,81501656).
文摘Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma,which affects tens of millions of people worldwide every year.Traumatic scars diminish the quality of life due to disfigurement,symptoms of pain and itch,and restricted motion.The pathogenesis and pathophysiology of traumatic scar remain elusive.The management for traumatic scars is comprised of surgical and non-surgical interventions such as pressure therapy,silicone,corticosteroid,and radiotherapy,which are chosen by clinicians based on the physical examinations of scars.Recently,great progress in treating traumatic scars has been achieved by the development of novel technologies including laser,intense pulsed light(IPL),radiofrequency,and ultrasound.The aim of this review article was to summarize the advances of these technologies for traumatic scars intervention.
文摘The demand for processed foods and the awareness about food quality and safety are increasing rapidly.The consumers’demand for minimally processed foods and growing competition in the market have made the processors to adopt newer non-thermal technologies that preserve nutrients and sensory properties of the products.Conventionally,heat processing of foods is carried out to convert raw material into value-added product,reduce or eliminate microbial load to improve safety,and extend shelf life.Some of the limitations of thermal processing techniques can be overcome by employing non-thermal processes.High hydrostatic pressure,pulsed electric field,ultrasound,cold plasma,dense phase carbon dioxide,ozone,and pulsed light(PL)processing are gaining popularity in food processing.PL technology is a non-thermal technology,where sterilization and decontamination are achieved by impinging high-intensity light pulses of short durations on surfaces of foods and high-transmission liquids.Although a few reports on the PL technology are available,in-depth studies on this are needed to adopt at a commercial level.The present review provides an overview of light-based processing of foods and covers important aspects such as different PL systems used for processing of foods,mode of action of PL on microbes,the effect of PL on liquid foods,surface decontamination of foods and parameters that affect PL efficacy,combination processing with PL.With the growing demand in non-thermal processing for the technological advancement in the area of generation of light,light-based processing will be a promising technology for microbial load reduction.
基金Supported by grants of the National Natural Science of China(No.81000700No.81573072)
文摘Objective We investigated the efficacy and safety of 1064 nm Nd： YAG laser, intense pulsed light （IPL）, and lauromacrogol injection in the treatment of hemangioma, in order to evaluate the value of color Doppler ultrasound guidance in choosing the optimal treatment modality. Methods Infantile patients who were clinical diagnosed as hemangiomas were randomly divided into group A, who had color Doppler ultrasound examinations before the treatment, and group B who had the treatment without ultrasound evaluation. Patients in the group A were assigned into subgroups according to the depth of lesion by sonography： group A-1 for those who had a lesion depth 〈1.2 mm, and took intense pulsed light therapy; group A-2 for those who had a lesion depth ≥1.2mm and 〈 3 mm, and took long pulse 1064 nm Nd：YAG laser therapy; group A-3 for those who had a lesion depth ≥3mm and 〈5 mm, and were treated by IPL combined with long pulse 1064 nm Nd：YAG laser treatment; Group A-4 for those who had a lesion depth ≥5 mm, and took lauromacrogol injection therapy. Patients in the group B took long pulse 1064 nm Nd：YAG laser treatment without preoperative ultrasound evaluation. The efficacy and adverse reactions of the treatments between the groups were evaluated and compared statistically. Results Totally 113 patients with 128 skin lesions were enrolled in this study, 85 in the group A （mean age 6.8±7.9 months） and 28 in the group B （mean age 6.9±9.9 months）. The mean depth of hemangioma was 3.3±1.1 mm in the group A, ranging from 0.5-7.8 mm, with 0.8±0.4 mm, 2.2±0.4 mm, 4.2±0.6 mm and 6.2±0.7 mm in group A1, A2, A3 and A4, respectively. The cure rates and effective rates in the group A were significantly higher than those in the group B （cure rates： 64.5% vs 56.3%, U=3.378, P=0.045; effective rates： 89.5% vs 78.1%, U=4.163, P=0.041）. The adverse effect rates of the group A （vesicle 20.0%, pigmentation 46.9%, scarring 17.7%） were lower than those of the group B （vesicle 21.9%, pigmentation 60.4%, scarring 25.0%）. Incidences of pigmentation and scarring were statistically significantly different （U=3.884, P=0.034, and U=4.016, P=0.032 respectively） between the two groups. Conclusion With the guidance of color Doppler ultrasound, the efficacy and safety of long pulse 1064 nmNd：YAG laser, intense pulsed light, and lauromacrogol injection in the treatment of infantile hemangioma have better outcomes compared to laser treatment alone without preoperative ultrasound examination.
