马泰奥蒂广场公共花园(Piazza Matteotti Public Gardens)的改造项目旨在重塑这一始建于20世纪初的历史场所,该场所由于历次干预而变得面目全非。此次改造旨在为位于意大利托斯卡纳阿雷佐市(Arezzo, Tuscany)的卡斯蒂廖内菲伦蒂诺镇(Cas...马泰奥蒂广场公共花园(Piazza Matteotti Public Gardens)的改造项目旨在重塑这一始建于20世纪初的历史场所,该场所由于历次干预而变得面目全非。此次改造旨在为位于意大利托斯卡纳阿雷佐市(Arezzo, Tuscany)的卡斯蒂廖内菲伦蒂诺镇(Castiglion Fiorentino)的历史中心门户重塑场所认同,在瓦尔迪基亚纳(Val di Chiana)地区最美丽的观景平台之一,为市民营造一个热情好客且充满活力的空间。展开更多
The long-standing use of portable toilet cubicles by residents of Shanghai’s narrow,labyrinthine alleys came to an end in September 2025 after the city largely finished building public toilets to make up their lack o...The long-standing use of portable toilet cubicles by residents of Shanghai’s narrow,labyrinthine alleys came to an end in September 2025 after the city largely finished building public toilets to make up their lack of sanitation facilities.The project,targeting 14,082 households,started last year.展开更多
GENERAL INFORMATION International Journal of Ophthalmology—IJO,published continuously since 2008,a global ophthalmological scientific publication and a peer-reviewed,open access periodical published in print and onli...GENERAL INFORMATION International Journal of Ophthalmology—IJO,published continuously since 2008,a global ophthalmological scientific publication and a peer-reviewed,open access periodical published in print and online monthly(ISSN:2222-3959 print,ISSN:2227-4898 online).IJO is sponsored by the Chinese Medical Association Xi’an Branch,China and obtains guidance.It is indexed in SCI,PubMed,PubMed Central,Chemical Abstract,Scopus,EMBASE etc.The latest JCR IF is 1.8,Five-year Impact Factor is 1.8,CiteScore in 2024 is 2.8.展开更多
Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmenta...Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmental health impacts.This article presents a concise overview of the components of PTS,pertinent environmental regulations,and conventional detection methodologies.Additionally,we offer an in-depth review of the principles,development,and practical applications of surface-enhanced Raman scattering(SERS)in environmental monitoring,emphasizing the advancements in detecting trace amounts of PTS in complex environmental matrices.Recent progress in enhancing SERS sensitivity,improving selectivity,and practical implementations are detailed,showcasing innovative materials and methods.Integrating SERS with advanced algorithms are highlighted as pivotal areas for future research.展开更多
With the sustained growth of the economy and significant changes in social demographics,the issue of elderly-related diseases has increasingly drawn attention,particularly.Alzheimer’s disease(AD),as a representative ...With the sustained growth of the economy and significant changes in social demographics,the issue of elderly-related diseases has increasingly drawn attention,particularly.Alzheimer’s disease(AD),as a representative disease of neurodegenerative diseases,has become a major challenge,affecting the health and quality of life of the elderly population severely.In recent years,the incidence,prevalence and mortality rates of AD have increased in China,imposing substantial economic burdens on families,society and the entire healthcare system.To proactively address this challenge and respond to the national‘Healthy China Action’initiative,leading experts from authoritative institutions jointly authored the China Alzheimer Report 2025.Building on previous editions,this report updates epidemiological data on AD in China,thoroughly analyses the latest economic burdens of the disease and comprehensively evaluates the current status of AD diagnosis and treatment services,as well as the allocation of public health resources in our country.Its release reflects China’s progress in AD research and prevention,underscores societal concern for elderly health and aims to provide scientific guidance and data support for AD prevention,diagnosis and treatment.It also facilitates academic exchanges and cooperation,enhancing public awareness and promoting active participation in elderly healthcare,towards achieving‘healthy ageing’in China.展开更多
In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional c...In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional culture into rural public spaces.Field research has been conducted to assess the current utilization of regional culture in the public spaces of Xiaomaopoying Village.Subsequently,design optimization strategies are analyzed and proposed.Additionally,the practical application of regional cultural elements is examined,in order to offer guidance for the application of cultural creation of traditional characteristic villages in rural public spaces.展开更多
BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early preventi...BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early prevention and management,especially in underrepresented areas like Guizhou Province,China,where geographic and ethnic diversity may influence the disease’s prevalence and risk profiles.AIM To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in Guizhou Province,providing essential data for early prevention strategies.METHODS A multi-center retrospective study was conducted,dividing participants into GDM and non-GDM groups according to standardized diagnostic criteria.Data were collected from 103629 deliveries across 40 hospitals in Guizhou.Various demographic,clinical,and laboratory parameters were analyzed using logistic regression to identify risk and protective factors for GDM.RESULTS Among the 103629 deliveries,18957 cases of GDM were identified,with an incidence of approximately 18.3%.The risk of GDM was higher in the Han ethnic group compared to minority ethnic groups.The Dong ethnic group had the lowest incidence among the minorities.Key risk factors identified included older age(especially>35 years),higher pre-pregnancy body mass index(BMI),light physical activity,gravidity,family history of diabetes,hemoglobin,aspartate aminotransferase,alanine aminotransferase,and direct bilirubin.Protective factors included higher education level,total protein,and albumin.There were also differences based on blood type,with type A associated with higher risk.CONCLUSION The incidence rate in Guizhou is 18.3%.Older age(especially>35 years),Han ethnicity,lower education level,higher pre-pregnancy BMI,light physical activity,and higher gravidity are the main risk factors for GDM.Laboratory findings indicate that higher hemoglobin,higher liver function parameters(alanine aminotransferase,aspartate aminotransferase,and direct bilirubin),and lower total protein and albumin are associated with a higher risk of GDM.Blood type A has a higher risk of GDM compared to blood types AB and O.展开更多
Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly c...Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly correlated with clinicopathological characteristics and prognostic outcomes of patients with breast cancer remains elusive.This study systematically investigated the clinical significance of ZWINT expression in breast cancer through integrated molecular subtyping and survival analysis.Methods We systematically characterized the spatial expression pattern of ZWINT across various breast cancer subtypes and assessed its prognostic significance using an integrated bioinformatics approach that involved multi-omics analysis.The approach included the Breast Cancer Gene-Expression Miner v5.1(bc-GenExMiner v5.1),TNMplot,MuTarget,PrognoScan database,and Database for Annotation,Visualization,and Integrated Discovery(DAVID).Results Our analysis revealed consistent upregulation of ZWINT mRNA and protein expression across distinct clinicopathological subtypes of breast cancer.ZWINT overexpression demonstrated significant co-occurrence with truncating mutations in cadherin 1(CDH1)and tumor protein p53(TP53),suggesting potential functional crosstalk in tumor progression pathways.The overexpression of ZWINT correlated with adverse clinical outcomes,showing 48%increased mortality risk(overall survival:HR 1.48,95%CI 1.23–1.79),66%higher recurrence probability(relapse-free survival:1.66,95%CI 1.50–1.84),and 63%elevated metastasis risk(distant metastasis-free survival:HR 1.63,95%CI 1.39–1.90).Multivariate Cox regression incorporating TNM staging and molecular subtypes confirmed ZWINT as an independent prognostic determinant(P<0.001,Harrell’s C-index=0.7827),which was validated through bootstrap resampling(1000 iterations).Conclusion ZWINT may serve as a potential biomarker for prognosis and a possible therapeutic target alongside TP53/CDH1 in breast cancer.展开更多
BACKGROUND Monkeypox(Mpox),is a disease of global public health concern,as it does not affect only countries in western and central Africa.AIM To assess Burundi healthcare workers(HCWs)s’level of knowledge and confid...BACKGROUND Monkeypox(Mpox),is a disease of global public health concern,as it does not affect only countries in western and central Africa.AIM To assess Burundi healthcare workers(HCWs)s’level of knowledge and confidence in the diagnosis and management of Mpox.METHODS We conducted a cross-sectional study via an online survey designed mainly from the World Health Organization course distributed among Burundi HCWs from June-July 2023.The questionnaire comprises 8 socioprofessional-related questions,22 questions about Mpox disease knowledge,and 3 questions to assess confidence in Mpox diagnosis and management.The data were analyzed via SPSS software version 25.0.A P value<0.05 was considered to indicate statistical significance.RESULTS The study sample comprised 471 HCWs who were mainly medical doctors(63.9%)and nurses(30.1%).None of the 22 questions concerning Mpox knowledge had at least 50%correct responses.A very low number of HCWs(17.4%)knew that Mpox has a vaccine.The confidence level to diagnose(21.20%),treat(18.00%)or prevent(23.30%)Mpox was low among HCWs.The confidence level in the diagnosis of Mpox was associated with the HCWs’age(P value=0.009),sex(P value<0.001),work experience(P value=0.002),and residence(P value<0.001).The confidence level to treat Mpox was significantly associated with the HCWs’age(P value=0.050),sex(P value<0.001),education(P value=0.033)and occupation(P value=0.005).The confidence level to prevent Mpox was associated with the HCWs’education(P value<0.001),work experience(P value=0.002),residence(P value<0.001)and type of work institution(P value=0.003).CONCLUSION This study revealed that HCWs have the lowest level of knowledge regarding Mpox and a lack of confidence in the ability to diagnose,treat or prevent it.There is an urgent need to organize continuing medical education programs on Mpox epidemiology and preparedness for Burundi HCWs.We encourage future researchers to assess potential hesitancy toward Mpox vaccination and its associated factors.展开更多
BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T...BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease progression.AIM To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with T2DM.METHODS One hundred patients with T2DM were selected as the research subjects.The patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table method.The conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing group.The rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two groups.RESULTS The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P<0.05).Before care,there was no significant difference in fasting blood glucose or 2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both groups.The cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than that of the conventional nursing group(98%vs 86%,P<0.05).CONCLUSION Community public health care based on conventional care of T2DM can achieve better blood sugar control,and improve patients’health cognitive level and self-management ability.展开更多
This study contests the prevalent perception of graffiti writing,especially tagging and bombing,as meaningless vandalism.It contends that graffiti is a form of expression with intrinsic political implications.Leveragi...This study contests the prevalent perception of graffiti writing,especially tagging and bombing,as meaningless vandalism.It contends that graffiti is a form of expression with intrinsic political implications.Leveraging the notion of spatial justice and Jacques Ranciere's philosophy,I demonstrate how graffiti reclaims urban visibility against the commercial monopoly of visibility in public spaces and challenges the inequitable allocation of opportunities for self-expression in modern cities.Despite writers'common denial of political motives,their actions may be interpreted as manifestations of resistance within wider sociospatial conflicts.This study situates grffti within discussions of political art,spatial commodification,and everyday resistance,proposing a normative framework for viewing the art of the urban signature as an activity that redefines"the community that speaks."展开更多
Food Science and Human Wellness (FSHW ISSN:2213-4530,CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics...Food Science and Human Wellness (FSHW ISSN:2213-4530,CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.展开更多
Objective:This review aimed to identify the barriers and facilitators to equitable coronavirus disease 2019(COVID-19)vaccine distribution in Nigeria using the consolidated framework for implementation research(CFIR).M...Objective:This review aimed to identify the barriers and facilitators to equitable coronavirus disease 2019(COVID-19)vaccine distribution in Nigeria using the consolidated framework for implementation research(CFIR).Methods:A comprehensive search strategy was applied across five databases—Web of Science,MEDLINE,EMBASE,CAB Direct,and CINAHL.The search,conducted as part of a scoping review,yielded 2,751 citations.Seven studies met the inclusion criteria after screening.Data were extracted and analyzed using CFIR constructs to identify key barriers and facilitators to equitable vaccine distribution.Results:Six barriers were identified:limited physical and socioeconomic access,bribery,nepotism,and insufficient availability of translated information.Facilitators included community involvement as local monitoring agents,unannounced staff inspections,healthcare worker training tailored to community needs,and localized outreach strategies such as jingles and call-in programs.CFIR constructs,including Local Conditions,Tailoring Strategies,Available Resources,and Physical Infrastructure,provided a framework for analyzing the findings.Conclusion:This review highlights significant barriers and promising facilitators to equitable vaccine distribution in Nigeria.Targeted interventions,such as community engagement,anti-corruption measures,and culturally tailored strategies,are critical to addressing these challenges and improving access.These findings underscore the need for localized,equity-focused approaches to enhance vaccine distribution systems in Nigeria and other low-resource settings.展开更多
《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标...《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel indicator.The DALY,a composite metric incorporating temporal and quali...In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel indicator.The DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability status.This review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its application.In contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability Weights.Claiming to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and sensitivity.The DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international literature.Despite widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible results.Given the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is warranted.This reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.展开更多
While people met in order to socialize on public spaces in the past, these areas are perceived as a ‘alone in the crowds’ by people who are in the loneliness of modern era, as well as these areas still serve as a so...While people met in order to socialize on public spaces in the past, these areas are perceived as a ‘alone in the crowds’ by people who are in the loneliness of modern era, as well as these areas still serve as a social area. Individuals from all of society, especially minority groups, feel that they are accepted and they show themselves in a way in the public space. Even though the perception and usage of public space have changed in time, people still feel free themselves in these areas. However, ‘terrorism’, which is a reality in today's world, is one of the cases which pose danger to the public spaces. Thus, the image of these areas has changed from “the areas where individuals they feel freer” to “the areas where people are vulnerable to many potential attacks”. This study tells you how the public perception has changed over time and examine the intended use of the public due to these changes. Terrorist activities increased all of the World and public spaces of the individual in the face of this reality, perception and Jane Jacobs, urban life and public relations with the charm of the terrorist phenomenon is one of the main problems the 21st century in the context of views on security are discussed. Also in this report, in order to provide a team recommendation for safe public space taking into account the author's views on security was available. For this purpose, the metropolis of Istanbul is selected as the study area were interviewed and the people living in Istanbul with internet environment. At the end of the 90s until today has changed the perception of how the public and in the public domain when individuals are discussed how they use.展开更多
The aim of this study is to determine the level to which the public is aware about ITS(intelligent transportation systems)technologies and how they perceive the potential advantages and inhibitors of ITS in Michigan.A...The aim of this study is to determine the level to which the public is aware about ITS(intelligent transportation systems)technologies and how they perceive the potential advantages and inhibitors of ITS in Michigan.A survey was performed with 200 participants living in Michigan,in urban,suburban and rural areas.Questions covered in the survey included how often and how bad traffic congestion occurred,how familiar travelers were with ITS technologies(adaptive traffic signals,real time monitoring of the traffic)and how much support travelers would provide for ITS initiatives.Results reveal that there is a high degree of traffic congestion awareness,there is low public awareness of ITS technologies.While respondents who were aware of ITS solutions had positive views about deploying them,especially in urban areas,they were less supportive of ITS solutions than they were among those who did not know much about these.Factors including area of residence,commute time and age were perceived to influence ITS along with more positive attitudes to ITS amongst urban dwellers and younger respondents.Analysis of key barriers to ITS implementation reflected high initial costs,challenges with technical integration and users’concerns surrounding privacy.展开更多
文摘马泰奥蒂广场公共花园(Piazza Matteotti Public Gardens)的改造项目旨在重塑这一始建于20世纪初的历史场所,该场所由于历次干预而变得面目全非。此次改造旨在为位于意大利托斯卡纳阿雷佐市(Arezzo, Tuscany)的卡斯蒂廖内菲伦蒂诺镇(Castiglion Fiorentino)的历史中心门户重塑场所认同,在瓦尔迪基亚纳(Val di Chiana)地区最美丽的观景平台之一,为市民营造一个热情好客且充满活力的空间。
文摘The long-standing use of portable toilet cubicles by residents of Shanghai’s narrow,labyrinthine alleys came to an end in September 2025 after the city largely finished building public toilets to make up their lack of sanitation facilities.The project,targeting 14,082 households,started last year.
文摘GENERAL INFORMATION International Journal of Ophthalmology—IJO,published continuously since 2008,a global ophthalmological scientific publication and a peer-reviewed,open access periodical published in print and online monthly(ISSN:2222-3959 print,ISSN:2227-4898 online).IJO is sponsored by the Chinese Medical Association Xi’an Branch,China and obtains guidance.It is indexed in SCI,PubMed,PubMed Central,Chemical Abstract,Scopus,EMBASE etc.The latest JCR IF is 1.8,Five-year Impact Factor is 1.8,CiteScore in 2024 is 2.8.
基金supported by the National Natural Science Foundation of China(Nos.42077299,and U21A20290)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750400)the Ordos Key Research and Development Program(No.YF20240037).
文摘Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmental health impacts.This article presents a concise overview of the components of PTS,pertinent environmental regulations,and conventional detection methodologies.Additionally,we offer an in-depth review of the principles,development,and practical applications of surface-enhanced Raman scattering(SERS)in environmental monitoring,emphasizing the advancements in detecting trace amounts of PTS in complex environmental matrices.Recent progress in enhancing SERS sensitivity,improving selectivity,and practical implementations are detailed,showcasing innovative materials and methods.Integrating SERS with advanced algorithms are highlighted as pivotal areas for future research.
基金supported by a grant from Brain Science and BrainLike Intelligence Technology of the Ministry of Science and Technology of China(2021ZD0201804).
文摘With the sustained growth of the economy and significant changes in social demographics,the issue of elderly-related diseases has increasingly drawn attention,particularly.Alzheimer’s disease(AD),as a representative disease of neurodegenerative diseases,has become a major challenge,affecting the health and quality of life of the elderly population severely.In recent years,the incidence,prevalence and mortality rates of AD have increased in China,imposing substantial economic burdens on families,society and the entire healthcare system.To proactively address this challenge and respond to the national‘Healthy China Action’initiative,leading experts from authoritative institutions jointly authored the China Alzheimer Report 2025.Building on previous editions,this report updates epidemiological data on AD in China,thoroughly analyses the latest economic burdens of the disease and comprehensively evaluates the current status of AD diagnosis and treatment services,as well as the allocation of public health resources in our country.Its release reflects China’s progress in AD research and prevention,underscores societal concern for elderly health and aims to provide scientific guidance and data support for AD prevention,diagnosis and treatment.It also facilitates academic exchanges and cooperation,enhancing public awareness and promoting active participation in elderly healthcare,towards achieving‘healthy ageing’in China.
文摘In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional culture into rural public spaces.Field research has been conducted to assess the current utilization of regional culture in the public spaces of Xiaomaopoying Village.Subsequently,design optimization strategies are analyzed and proposed.Additionally,the practical application of regional cultural elements is examined,in order to offer guidance for the application of cultural creation of traditional characteristic villages in rural public spaces.
基金National Natural Science Foundation of China,No.81960284Science and Technology Support Program of Science and Technology Department of Guizhou Province,No.Qian Ke He Zhi Cheng[2022]Yi Ban 183.
文摘BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early prevention and management,especially in underrepresented areas like Guizhou Province,China,where geographic and ethnic diversity may influence the disease’s prevalence and risk profiles.AIM To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in Guizhou Province,providing essential data for early prevention strategies.METHODS A multi-center retrospective study was conducted,dividing participants into GDM and non-GDM groups according to standardized diagnostic criteria.Data were collected from 103629 deliveries across 40 hospitals in Guizhou.Various demographic,clinical,and laboratory parameters were analyzed using logistic regression to identify risk and protective factors for GDM.RESULTS Among the 103629 deliveries,18957 cases of GDM were identified,with an incidence of approximately 18.3%.The risk of GDM was higher in the Han ethnic group compared to minority ethnic groups.The Dong ethnic group had the lowest incidence among the minorities.Key risk factors identified included older age(especially>35 years),higher pre-pregnancy body mass index(BMI),light physical activity,gravidity,family history of diabetes,hemoglobin,aspartate aminotransferase,alanine aminotransferase,and direct bilirubin.Protective factors included higher education level,total protein,and albumin.There were also differences based on blood type,with type A associated with higher risk.CONCLUSION The incidence rate in Guizhou is 18.3%.Older age(especially>35 years),Han ethnicity,lower education level,higher pre-pregnancy BMI,light physical activity,and higher gravidity are the main risk factors for GDM.Laboratory findings indicate that higher hemoglobin,higher liver function parameters(alanine aminotransferase,aspartate aminotransferase,and direct bilirubin),and lower total protein and albumin are associated with a higher risk of GDM.Blood type A has a higher risk of GDM compared to blood types AB and O.
基金supported by the Research Project of Maternal and Child Health Hospital of Hubei Province(No.2023SFYM008)Key Project of Hubei Provincial Natural Science Foundation(No.JCZRLH202500304).
文摘Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly correlated with clinicopathological characteristics and prognostic outcomes of patients with breast cancer remains elusive.This study systematically investigated the clinical significance of ZWINT expression in breast cancer through integrated molecular subtyping and survival analysis.Methods We systematically characterized the spatial expression pattern of ZWINT across various breast cancer subtypes and assessed its prognostic significance using an integrated bioinformatics approach that involved multi-omics analysis.The approach included the Breast Cancer Gene-Expression Miner v5.1(bc-GenExMiner v5.1),TNMplot,MuTarget,PrognoScan database,and Database for Annotation,Visualization,and Integrated Discovery(DAVID).Results Our analysis revealed consistent upregulation of ZWINT mRNA and protein expression across distinct clinicopathological subtypes of breast cancer.ZWINT overexpression demonstrated significant co-occurrence with truncating mutations in cadherin 1(CDH1)and tumor protein p53(TP53),suggesting potential functional crosstalk in tumor progression pathways.The overexpression of ZWINT correlated with adverse clinical outcomes,showing 48%increased mortality risk(overall survival:HR 1.48,95%CI 1.23–1.79),66%higher recurrence probability(relapse-free survival:1.66,95%CI 1.50–1.84),and 63%elevated metastasis risk(distant metastasis-free survival:HR 1.63,95%CI 1.39–1.90).Multivariate Cox regression incorporating TNM staging and molecular subtypes confirmed ZWINT as an independent prognostic determinant(P<0.001,Harrell’s C-index=0.7827),which was validated through bootstrap resampling(1000 iterations).Conclusion ZWINT may serve as a potential biomarker for prognosis and a possible therapeutic target alongside TP53/CDH1 in breast cancer.
文摘BACKGROUND Monkeypox(Mpox),is a disease of global public health concern,as it does not affect only countries in western and central Africa.AIM To assess Burundi healthcare workers(HCWs)s’level of knowledge and confidence in the diagnosis and management of Mpox.METHODS We conducted a cross-sectional study via an online survey designed mainly from the World Health Organization course distributed among Burundi HCWs from June-July 2023.The questionnaire comprises 8 socioprofessional-related questions,22 questions about Mpox disease knowledge,and 3 questions to assess confidence in Mpox diagnosis and management.The data were analyzed via SPSS software version 25.0.A P value<0.05 was considered to indicate statistical significance.RESULTS The study sample comprised 471 HCWs who were mainly medical doctors(63.9%)and nurses(30.1%).None of the 22 questions concerning Mpox knowledge had at least 50%correct responses.A very low number of HCWs(17.4%)knew that Mpox has a vaccine.The confidence level to diagnose(21.20%),treat(18.00%)or prevent(23.30%)Mpox was low among HCWs.The confidence level in the diagnosis of Mpox was associated with the HCWs’age(P value=0.009),sex(P value<0.001),work experience(P value=0.002),and residence(P value<0.001).The confidence level to treat Mpox was significantly associated with the HCWs’age(P value=0.050),sex(P value<0.001),education(P value=0.033)and occupation(P value=0.005).The confidence level to prevent Mpox was associated with the HCWs’education(P value<0.001),work experience(P value=0.002),residence(P value<0.001)and type of work institution(P value=0.003).CONCLUSION This study revealed that HCWs have the lowest level of knowledge regarding Mpox and a lack of confidence in the ability to diagnose,treat or prevent it.There is an urgent need to organize continuing medical education programs on Mpox epidemiology and preparedness for Burundi HCWs.We encourage future researchers to assess potential hesitancy toward Mpox vaccination and its associated factors.
文摘BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease progression.AIM To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with T2DM.METHODS One hundred patients with T2DM were selected as the research subjects.The patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table method.The conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing group.The rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two groups.RESULTS The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P<0.05).Before care,there was no significant difference in fasting blood glucose or 2-h postprandial blood glucose between the two groups of patients(P>0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both groups.The cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than that of the conventional nursing group(98%vs 86%,P<0.05).CONCLUSION Community public health care based on conventional care of T2DM can achieve better blood sugar control,and improve patients’health cognitive level and self-management ability.
文摘This study contests the prevalent perception of graffiti writing,especially tagging and bombing,as meaningless vandalism.It contends that graffiti is a form of expression with intrinsic political implications.Leveraging the notion of spatial justice and Jacques Ranciere's philosophy,I demonstrate how graffiti reclaims urban visibility against the commercial monopoly of visibility in public spaces and challenges the inequitable allocation of opportunities for self-expression in modern cities.Despite writers'common denial of political motives,their actions may be interpreted as manifestations of resistance within wider sociospatial conflicts.This study situates grffti within discussions of political art,spatial commodification,and everyday resistance,proposing a normative framework for viewing the art of the urban signature as an activity that redefines"the community that speaks."
文摘Food Science and Human Wellness (FSHW ISSN:2213-4530,CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.
文摘Objective:This review aimed to identify the barriers and facilitators to equitable coronavirus disease 2019(COVID-19)vaccine distribution in Nigeria using the consolidated framework for implementation research(CFIR).Methods:A comprehensive search strategy was applied across five databases—Web of Science,MEDLINE,EMBASE,CAB Direct,and CINAHL.The search,conducted as part of a scoping review,yielded 2,751 citations.Seven studies met the inclusion criteria after screening.Data were extracted and analyzed using CFIR constructs to identify key barriers and facilitators to equitable vaccine distribution.Results:Six barriers were identified:limited physical and socioeconomic access,bribery,nepotism,and insufficient availability of translated information.Facilitators included community involvement as local monitoring agents,unannounced staff inspections,healthcare worker training tailored to community needs,and localized outreach strategies such as jingles and call-in programs.CFIR constructs,including Local Conditions,Tailoring Strategies,Available Resources,and Physical Infrastructure,provided a framework for analyzing the findings.Conclusion:This review highlights significant barriers and promising facilitators to equitable vaccine distribution in Nigeria.Targeted interventions,such as community engagement,anti-corruption measures,and culturally tailored strategies,are critical to addressing these challenges and improving access.These findings underscore the need for localized,equity-focused approaches to enhance vaccine distribution systems in Nigeria and other low-resource settings.
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel indicator.The DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability status.This review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its application.In contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability Weights.Claiming to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and sensitivity.The DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international literature.Despite widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible results.Given the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is warranted.This reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.
文摘While people met in order to socialize on public spaces in the past, these areas are perceived as a ‘alone in the crowds’ by people who are in the loneliness of modern era, as well as these areas still serve as a social area. Individuals from all of society, especially minority groups, feel that they are accepted and they show themselves in a way in the public space. Even though the perception and usage of public space have changed in time, people still feel free themselves in these areas. However, ‘terrorism’, which is a reality in today's world, is one of the cases which pose danger to the public spaces. Thus, the image of these areas has changed from “the areas where individuals they feel freer” to “the areas where people are vulnerable to many potential attacks”. This study tells you how the public perception has changed over time and examine the intended use of the public due to these changes. Terrorist activities increased all of the World and public spaces of the individual in the face of this reality, perception and Jane Jacobs, urban life and public relations with the charm of the terrorist phenomenon is one of the main problems the 21st century in the context of views on security are discussed. Also in this report, in order to provide a team recommendation for safe public space taking into account the author's views on security was available. For this purpose, the metropolis of Istanbul is selected as the study area were interviewed and the people living in Istanbul with internet environment. At the end of the 90s until today has changed the perception of how the public and in the public domain when individuals are discussed how they use.
文摘The aim of this study is to determine the level to which the public is aware about ITS(intelligent transportation systems)technologies and how they perceive the potential advantages and inhibitors of ITS in Michigan.A survey was performed with 200 participants living in Michigan,in urban,suburban and rural areas.Questions covered in the survey included how often and how bad traffic congestion occurred,how familiar travelers were with ITS technologies(adaptive traffic signals,real time monitoring of the traffic)and how much support travelers would provide for ITS initiatives.Results reveal that there is a high degree of traffic congestion awareness,there is low public awareness of ITS technologies.While respondents who were aware of ITS solutions had positive views about deploying them,especially in urban areas,they were less supportive of ITS solutions than they were among those who did not know much about these.Factors including area of residence,commute time and age were perceived to influence ITS along with more positive attitudes to ITS amongst urban dwellers and younger respondents.Analysis of key barriers to ITS implementation reflected high initial costs,challenges with technical integration and users’concerns surrounding privacy.
