Objective:Nurse-led virtual outpatient clinics are now a familiar component of healthcare delivery across many disciplines,including cancer care,or thopedics,rheumatology,and gastroenterology.However,establishing a nu...Objective:Nurse-led virtual outpatient clinics are now a familiar component of healthcare delivery across many disciplines,including cancer care,or thopedics,rheumatology,and gastroenterology.However,establishing a nurse-led vir tual clinic is challenging for nursing management,par ticularly regarding resources.We aimed to investigate nursing practices and processes and patient experiences in relation to vir tual outpatient clinics.Methods:This was a cross-sectional,descriptive study using mixed data collection methods.Patients(n=324)from 4 specialist clinics completed the Virtual Clinics Patient Satisfaction Questionnaire(VCSQ)survey.Five Nurse Specialists participated in a focus group interview.Results:Most participants(86.3%)reported being satisfied/very satisfied with the virtual clinics,particularly those that were nurse-led.Nurse specialists identified electronic health records(EHRs)and additional IT and administrative support as important for efficiency and effectiveness of the clinics.Conclusions:Nurse-led virtual clinics can be an effective and efficient way to provide care to patients.Nurse managers need to ensure supportive structures are in place,for example,dedicated administrators,IT support and infrastructure,education/training,and relevant policies/procedures.The success of nurse-led virtual services requires key infrastructure to support nursing staff and sustain this service.展开更多
We found the qualitative study by Xu et al.on how patients feel about laparoscopic incisions under enhanced recovery after surgery(ERAS)protocols to be very interesting.1 Xu et al.carried out a qualitative study on pa...We found the qualitative study by Xu et al.on how patients feel about laparoscopic incisions under enhanced recovery after surgery(ERAS)protocols to be very interesting.1 Xu et al.carried out a qualitative study on patient experience with laparoscopic incisions under an ERAS protocol to highlight the problem of psychosocial and aesthetic concerns,which are often overlooked when planning surgical operations.This study,which involved semistructured interviews with sixteen people,aimed to narrow perioperative education and the decision-making process for incision site selection,thus making the processes more focused on patient priorities.The study is based on a timely but under-researched subject area;however,it is possible to outline four possible areas of improvement that would allow the study to be more transparent and,at the same time,more applicable to clinical practice.展开更多
Objectives Nurses’clinical research activities have contributed to optimizing the care process and improving patient outcomes,and generative artificial intelligence(GAI)may help clinical nurses strengthen their resea...Objectives Nurses’clinical research activities have contributed to optimizing the care process and improving patient outcomes,and generative artificial intelligence(GAI)may help clinical nurses strengthen their research skills.To support research,this study aimed to explore the Chinese nurses’perceptions and experiences of GAI training.Methods This study used a descriptive qualitative design.The China Nurses Network conducted a three-day training session on“GAI for Nursing Research”theme,we selected 23 nurses by a convenience sampling method among participating in the training.The researchers conducted three focus group interviews at the end of each day.All focus groups were interviewed face-to-face to facilitate interaction,data collection,and observation.The data were analyzed using conventional content analysis and coded manually.Results The results showed that nurses’use of GAI to support scientific research was dynamic and characterized by evolving perceptions and practices.Four themes and 11 sub-themes emerged from the analysis:1)utilization efficacy:cope with research ability,affected by many factors;2)booster research:growth and challenges go hand in hand;3)role reversal:from GAI-dominated to nurse-dominated;4)beautiful dream:more features on research,more assistants on clinical care.Conclusions The effectiveness of GAI in supporting clinical nurses in conducting research is mainly limited by differences in personal research literacy,lack of ethical regulation,and information accuracy.In the future,it is necessary to improve nurses’relevant skills through specialized training and promote the standardization of technical regulations to ensure the appropriate application of GAI in nursing research.展开更多
Background: Exposure to adverse childhood experiences (ACEs) is associated with a higher likelihood of developing psychological disorders among adolescents. The current study aimed to analyze the effect of independent...Background: Exposure to adverse childhood experiences (ACEs) is associated with a higher likelihood of developing psychological disorders among adolescents. The current study aimed to analyze the effect of independent and cumulative effects of ACEs exposure on the likelihood of Posttraumatic Stress Disorder (PTSD) and a Complex PTSD (CPSTD) diagnosis in Indian adolescents. Methods: A sample of 411 schoolchildren participated in the study. It was collected data on exposure to ACEs, PTSD, CPTSD, and attachment styles. Results: It was found that exposure to bullying and threats of violence was significantly associated with PTSD and CPTSD diagnosis, and exposure to physical violence and serious illness was associated with CPTSD diagnosis. Exposure to one ACE and exposure to 2 - 3 ACEs were associated with PTSD and CPTSD diagnosis, while exposure to 4 - 5 ACEs was associated with CPTSD diagnosis. Preoccupied and fearful attachment styles were significantly associated with PTSD and CPTSD diagnosis. Conclusion: The results of the study suggest that biological, psychological, and social factors interact and contribute to the differential prevalence of ACE, attachment styles, and PTSD/CPTSD. This study emphasizes the need of addressing childhood trauma as a public health priority in India.展开更多
Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A t...Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A total of 27 patients with pancreatic cancer undergoing chemotherapy at two medical institutions were recruited between November 2023 and August 2024.Semi-structured interviews were conducted in person or over the phone.Data were analyzed using traditional content and thematic analyses.Results:Three themes were identified:symptom experience,self-coping patterns,and existing obstacles.During the early stages of chemotherapy,patients reported a higher frequency of unpleasant symptoms and recognized these symptoms earlier in the treatment course.Patients in the early stages primarily relied on external support to cope with symptoms,while those in the later stages adopted self-care strategies.Several challenges related to unpleasant symptoms were observed,which appeared to correlate with the self-coping patterns employed.Conclusion:Patients with pancreatic cancer undergoing chemotherapy experience a complex and diverse range of symptoms,with varying coping patterns at different stages of treatment.Symptom management during chemotherapy presents significant challenges.Healthcare providers should improve the ongoing monitoring of symptoms post-chemotherapy.By linking patients’symptom experiences and self-coping patterns at different stages of chemotherapy to their specific challenges,personalized symptom management strategies can be developed to enhance care quality.展开更多
Objective:To explore the self-management experiences and outpatient nursing needs of intestinal stoma patients during the post-discharge transition period,in order to provide a basis for scientific decision-making in ...Objective:To explore the self-management experiences and outpatient nursing needs of intestinal stoma patients during the post-discharge transition period,in order to provide a basis for scientific decision-making in patient self-care and improvements in specialized stoma outpatient services.Methods:Using purposive sampling,13 colorectal cancer patients in the post-discharge transition period who had undergone intestinal stoma surgery were selected from a tertiary hospital in Shandong Province between November 2024 and March 2025.Semi-structured interviews were conducted,and data were analyzed using Colaizzi’s seven-step method to extract themes.Results:Three core themes were identified:challenges in self-management during the transition period,outpatient nursing needs during the transition period,and gaps in doctor-patient information continuity.Conclusion:Future efforts should focus on high-risk groups of stoma patients during the transition period by building intelligent and systematic outpatient guidance and support systems to improve their quality of life.展开更多
Background:Adverse childhood experiences(ACEs)are a significant issue in adolescent health due to their robust correlation with deficits in executive functions(EF)and health risk behaviors(HRBs).This study aimed to ex...Background:Adverse childhood experiences(ACEs)are a significant issue in adolescent health due to their robust correlation with deficits in executive functions(EF)and health risk behaviors(HRBs).This study aimed to examine the association between ACEs and a range of HRBs,including substance use,sexual risk behavior,suicidal ideation,physical inactivity,and violence.Methods:This cross-sectional study used self-administered questionnaire and cluster sampling in seven junior high schools in Samarinda,Indonesia,with a sample size of 534 students.Data analysis using descriptive statistics,the Chi-square test,the independent t-test,ANOVA,binary logistic regression,and mediation analysis with macro-PROCESS.Results:The most common ACEs were community violence(68.0%),physical neglect(52.8%),psychological/emotional abuse(52.6%),physical abuse(50.4%),and peer bullying(45.9%).Adolescents with more than five ACEs showed significantly higher involvement in smoking/vaping(67.9%),suicidal ideation(75.2%),sexual risk behavior(57.7%),bullying(64.3%),and physical fighting(59.7%)(p<0.001).ACEs were significantly correlated with EF deficits(r=0.471,p<0.01)and HRB(r=0.578,p<0.01).Regression analysis confirmed that ACEs predicted EF deficits(β=0.466,p<0.001)and HRB(β=0.469,p<0.001),with EF deficits partially mediating this relationship(β=0.107,95%CI[0.045,0.094]).In addition,two subdomains of EF deficits,self-motivation(β=0.042)and self-regulation of emotion(β=0.032),significantlymediated the relationship between ACEs and HRBs.Conclusion:These findings suggest an important role for EF deficits in linking childhood adversity to engagement in risky behaviors.Addressing ACEs and EF deficits(self-motivation and self-regulation of emotion)through early intervention may be important in reducing long-term health risks among Indonesian adolescents.展开更多
With the intensifying global climate crisis,carbon emissions trading has emerged as a crucial market-based instrument for emissions reduction,attracting significant attention from government agencies and academia worl...With the intensifying global climate crisis,carbon emissions trading has emerged as a crucial market-based instrument for emissions reduction,attracting significant attention from government agencies and academia worldwide.As of January 2024,28 carbon trading markets have been established globally,encompassing approximately 17%of global greenhouse gas emissions and serving approximately 1/3 of the global population.With various nations setting carbon neutrality targets and delineating carbon reduction pathways,the con-struction,operation,and regulatory frameworks of carbon markets are becoming increasingly refined and comprehensive.This study elucidates the importance and necessity of establishing carbon markets from the perspective of energy system transformation and sus-tainable economic development.Second,it provides a comparative analysis of the operational mechanisms,trading scales,and emission reduction outcomes of major carbon markets in the European Union,United States,and New Zealand,systematically summarizing their development processes and recent advancements.Finally,this study addresses issues and challenges in the construction of China’s carbon market.Drawing on the successful experiences of leading global carbon markets in institutional design and market operations,we pro-pose development strategies and recommendations for a carbon market with Chinese characteristics.These strategies are intended to align with international standards while meeting China’s national conditions,thereby contributing insights into the global carbon market trading system.展开更多
Wireless local area networks(WLANs)have witnessed rapid growth in the past 20 years,with maximum throughput as the key tech⁃nical objective.However,quality of experience(QoE)remains the primary concern for wireless ne...Wireless local area networks(WLANs)have witnessed rapid growth in the past 20 years,with maximum throughput as the key tech⁃nical objective.However,quality of experience(QoE)remains the primary concern for wireless network users.We point out that poor QoE is the most challenging issue in current WLANs and further analyze the key technical problems that cause poor QoE in WLANs,including fully distributed networking architectures,chaotic random access,awkward“high capability”issues,coarse-grained quality of service(QoS)archi⁃tectures,ubiquitous and complicated interference,“no place”for AI issues,and heavy burden of standard evolution.To the best of our knowl⁃edge,this is the first work to point out that poor QoE is the most challenging problem in current WLANs,and the first to systematically ana⁃lyze the technical problems that cause poor QoE in WLANs.We strongly suggest that achieving high experience(HEX)be the key objective of the next-generation WLANs.展开更多
Learning from the wisdom and insights of others remains one of the most effective paths to progress.This is the driving force behind our commitment to experience sharing.The March/April issue features three renowned i...Learning from the wisdom and insights of others remains one of the most effective paths to progress.This is the driving force behind our commitment to experience sharing.The March/April issue features three renowned international standardization experts who share their journeys,the strategic"hows and whys"of global participation,and the critical role of stakeholder engagement in shaping the future of the industry.展开更多
Heavy-ion collisions(HICs)is a unique experimental tool for investigating the properties of nuclear matter under extreme conditions in the laboratory.At HIRFL-CSR energies,HICs can create nuclear matter with 2-3 times...Heavy-ion collisions(HICs)is a unique experimental tool for investigating the properties of nuclear matter under extreme conditions in the laboratory.At HIRFL-CSR energies,HICs can create nuclear matter with 2-3 times the saturation density(ρ_(0)).The HIRFL-CSR external-target experiment(CEE)is a large-acceptance spectrometer designed to explore frontier topics in high-energy nuclear physics,such as the QCD phase structure and nuclear matter equation of states.In this letter,we introduce simulation and analysis software for the CEE experiment(CeeROOT).Based on the CEE conceptual design and CeeROOT software,the configurations of its subdetectors were optimized by considering foreseeable physical constraints.The final detector layout of the CEE spectrometer and its acceptances were validated through simulations of U+U collisions at 500 MeV/u and pp collisions at 2.8 GeV,which demonstrated that the CEE experiment will serve as a detector with wide acceptance and multi-particle identification capabilities for studying high-energy nuclear physics topics at HIRFL-CSR energies with pp,pA,and A A collisions.展开更多
Transitioning from outcrossing to self-fertilization is a widespread reproductive strategy in plants,especially in environments where pollination is limited.Despite its prevalence,this transition has rarely been exami...Transitioning from outcrossing to self-fertilization is a widespread reproductive strategy in plants,especially in environments where pollination is limited.Despite its prevalence,this transition has rarely been examined using transplant experiments,and previous studies have overlooked the contribution of the male parent in elucidating mating diversity.In this study,six transplanted populations were generated to investigate the relationship of the pollination environment with plant mating patterns and fecundity in Primula oreodoxa,a species that exhibits both distyly(predominantly outcrossing)and homostyly(predominantly selfing),based on data from 3582 individuals and 11 SSR markers.Homostylous plants had fruit and seed sets comparable to those of distylous plants at lower elevations but exhibited a clear reproductive advantage at higher elevations,particularly compared with the S morph.As elevation increased,the populational selfing rates increased,and the genetic diversity among the progeny was reduced.Furthermore,the visitation frequency of long-tongued pollinators was negatively and positively correlated with the selfing rate and number of mates,respectively,in the L and S morphs.In contrast,short-tongued pollinator visitation showed opposite correlations with the selfing rate and number of mates in homostylous morphs.In most populations,individuals functioned consistently as both female and male,and mating occurred randomly,suggesting a breakdown of the distyly polymorphism.Overall,our results provide experimental validation of the reproductive advantages of homostyly at high elevations by revealing that pollinator visitation shapes the selfing rate and mating diversity within populations,potentially driving the divergence of mating systems along environmental gradients.展开更多
Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecul...Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.展开更多
The Zeeman effect,a fundamental quantum phenomenon,demonstrates the interaction between magnetic fields and atomic systems.While precise spectroscopic measurements of this effect have advanced significantly,there rema...The Zeeman effect,a fundamental quantum phenomenon,demonstrates the interaction between magnetic fields and atomic systems.While precise spectroscopic measurements of this effect have advanced significantly,there remains a lack of simple,visually accessible demonstration for educational purposes.Here,we present a low-cost experiment that allows for direct visual observation of the Zeeman effect.Our setup involves a flame containing sodium(from table salt)placed in front of a sodium vapor lamp.When a magnetic field is applied to the flame,the shadow cast by the flame noticeably lightens,providing a clear,naked-eye demonstration of the Zeeman effect.Furthermore,we conduct two quantitative experiments using this setup,examining the effects of varying magnetic field strength and sodium concentration.This innovative approach not only enriches the experimental demonstration for teaching atomic physics at undergraduate and high school levels but also provides an open platform for students to explore the Zeeman effect through hands-on experience.展开更多
Recovered samples of Jilin H5 chondrite experimentally shocked to 12-133 GPa were studied to explore the behavior of opaque minerals under shock loading using SEM-EDS,Raman spectroscopy,and TIMA.The following results ...Recovered samples of Jilin H5 chondrite experimentally shocked to 12-133 GPa were studied to explore the behavior of opaque minerals under shock loading using SEM-EDS,Raman spectroscopy,and TIMA.The following results were obtained.Firstly,at pressures lower than 53GPa,the opaque minerals still keep the unmelted state,while at 78 GPa and higher,FeNi metal and troilite form eutectic intergrowths occurring as disorderly fine veinlets filling the shock-induced fractures in silicate minerals.Secondly,single kamacite grains still maintain their contour at 12 GPa,but a part of brittle troilite grains was fragmented and squeezed into the shock-induced fractures within kamacite grains.At53 and 133 GPa,many more troilite fragments are poured in the kamacite interior to form disordered hybrid aggregates or to form squiggly strips,respectively.Similar phenomena are observed within single troilite grains,but the mineral squeezed into troilite grains is kamacite.Thirdly,chromite is a hard and refractory oxide mineral.When the shock pressure rises step by step from 12 to 133 GPa,the shock effect of chromite is only fragmentation.Its grain size decreases from tens of um at 53 GPa to a few um at 133 GPa.And,fourthly,native copper exhibits distinct redistribution behavior at high temperature.In Jilin samples shock-loaded to 12 GPa,copper initially located at troilite-kamacite interfaces partially transferred into small troilite grains containing fine FeNi particles.At 53 and 133 GPa,native copper preferentially transferred into larger troilite grains containing more particles of eutectic FeNi metal.展开更多
The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the ...The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.展开更多
To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was struct...To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was structured around a project titled"Influenza Virus Analysis",comprising four progressive modules:database utilization and information retrieval,sequence alignment and phylogenetic analysis,functional and structural prediction,and omics data analysis.These modules were integrated into a coherent research workflow that connected fragmented knowledge and technical skills.During implementation,flipped classroom and group collaboration methods were employed,alongside the establishment of a diversified assessment system emphasizing process evaluation.Teaching practice indicates that the reform effectively enhances students professional application skills,learning experience,and scientific literacy,facilitating a shift from"tool operation"to"problem-solving"capabilities.This study provides a reference model for the reform of bioinformatics experimental teaching in local universities.展开更多
The subject matter of this paper is the thesis on the underdetermination of theory by experience,in the local account due to Duhem and in the global version due to Quine.This thesis has significant implications concer...The subject matter of this paper is the thesis on the underdetermination of theory by experience,in the local account due to Duhem and in the global version due to Quine.This thesis has significant implications concerning some epistemic uncertainty about the accuracy of the tested predictions of theories.We find this thesis plausible,though more feasible,limited to physical theories,as in Duhem’s approach.We examine the thesis of the impossibility of crucial experiments that Duhem finds implied by his thesis on empirical indeterminacy,as well as the thesis of the possibility of empirically equivalent theories that are logically incompatible,which Quine also finds linked to his thesis on empirical indeterminacy.From a conceptualist approach that acknowledges the abstract character of physical concepts and the idealized nature of physical laws,and assuming Hanson’s thesis on the theory laden of scientific observation,we conclude that the anterior Duhem’s thesis is sound,although the preceding Quine’s thesis does not seem viable.展开更多
基金supported by Nursing and Midwifery Practice Development Unit(NMPDU),Dublin South,Kildare,and Wicklow,Nurses preparedness for end of life conversations(No.P210537)。
文摘Objective:Nurse-led virtual outpatient clinics are now a familiar component of healthcare delivery across many disciplines,including cancer care,or thopedics,rheumatology,and gastroenterology.However,establishing a nurse-led vir tual clinic is challenging for nursing management,par ticularly regarding resources.We aimed to investigate nursing practices and processes and patient experiences in relation to vir tual outpatient clinics.Methods:This was a cross-sectional,descriptive study using mixed data collection methods.Patients(n=324)from 4 specialist clinics completed the Virtual Clinics Patient Satisfaction Questionnaire(VCSQ)survey.Five Nurse Specialists participated in a focus group interview.Results:Most participants(86.3%)reported being satisfied/very satisfied with the virtual clinics,particularly those that were nurse-led.Nurse specialists identified electronic health records(EHRs)and additional IT and administrative support as important for efficiency and effectiveness of the clinics.Conclusions:Nurse-led virtual clinics can be an effective and efficient way to provide care to patients.Nurse managers need to ensure supportive structures are in place,for example,dedicated administrators,IT support and infrastructure,education/training,and relevant policies/procedures.The success of nurse-led virtual services requires key infrastructure to support nursing staff and sustain this service.
文摘We found the qualitative study by Xu et al.on how patients feel about laparoscopic incisions under enhanced recovery after surgery(ERAS)protocols to be very interesting.1 Xu et al.carried out a qualitative study on patient experience with laparoscopic incisions under an ERAS protocol to highlight the problem of psychosocial and aesthetic concerns,which are often overlooked when planning surgical operations.This study,which involved semistructured interviews with sixteen people,aimed to narrow perioperative education and the decision-making process for incision site selection,thus making the processes more focused on patient priorities.The study is based on a timely but under-researched subject area;however,it is possible to outline four possible areas of improvement that would allow the study to be more transparent and,at the same time,more applicable to clinical practice.
基金supported by a grant from the National Natural Science Foundation of China(No.72174130)。
文摘Objectives Nurses’clinical research activities have contributed to optimizing the care process and improving patient outcomes,and generative artificial intelligence(GAI)may help clinical nurses strengthen their research skills.To support research,this study aimed to explore the Chinese nurses’perceptions and experiences of GAI training.Methods This study used a descriptive qualitative design.The China Nurses Network conducted a three-day training session on“GAI for Nursing Research”theme,we selected 23 nurses by a convenience sampling method among participating in the training.The researchers conducted three focus group interviews at the end of each day.All focus groups were interviewed face-to-face to facilitate interaction,data collection,and observation.The data were analyzed using conventional content analysis and coded manually.Results The results showed that nurses’use of GAI to support scientific research was dynamic and characterized by evolving perceptions and practices.Four themes and 11 sub-themes emerged from the analysis:1)utilization efficacy:cope with research ability,affected by many factors;2)booster research:growth and challenges go hand in hand;3)role reversal:from GAI-dominated to nurse-dominated;4)beautiful dream:more features on research,more assistants on clinical care.Conclusions The effectiveness of GAI in supporting clinical nurses in conducting research is mainly limited by differences in personal research literacy,lack of ethical regulation,and information accuracy.In the future,it is necessary to improve nurses’relevant skills through specialized training and promote the standardization of technical regulations to ensure the appropriate application of GAI in nursing research.
文摘Background: Exposure to adverse childhood experiences (ACEs) is associated with a higher likelihood of developing psychological disorders among adolescents. The current study aimed to analyze the effect of independent and cumulative effects of ACEs exposure on the likelihood of Posttraumatic Stress Disorder (PTSD) and a Complex PTSD (CPSTD) diagnosis in Indian adolescents. Methods: A sample of 411 schoolchildren participated in the study. It was collected data on exposure to ACEs, PTSD, CPTSD, and attachment styles. Results: It was found that exposure to bullying and threats of violence was significantly associated with PTSD and CPTSD diagnosis, and exposure to physical violence and serious illness was associated with CPTSD diagnosis. Exposure to one ACE and exposure to 2 - 3 ACEs were associated with PTSD and CPTSD diagnosis, while exposure to 4 - 5 ACEs was associated with CPTSD diagnosis. Preoccupied and fearful attachment styles were significantly associated with PTSD and CPTSD diagnosis. Conclusion: The results of the study suggest that biological, psychological, and social factors interact and contribute to the differential prevalence of ACE, attachment styles, and PTSD/CPTSD. This study emphasizes the need of addressing childhood trauma as a public health priority in India.
基金supported by the State Key Laboratory of Ultrasonic Medical Engineering/the Chongqing Science and Technology Bureau(Project No.2022KFKT7011)the Postdoctoral Fellowship Program of CPSF(GZC20233357)+1 种基金the Health Commission of Sichuan Province Medical Science and Technology Program(24QNMP007)the Medical Research Program of Health Commission of Chengdu(2023535).
文摘Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A total of 27 patients with pancreatic cancer undergoing chemotherapy at two medical institutions were recruited between November 2023 and August 2024.Semi-structured interviews were conducted in person or over the phone.Data were analyzed using traditional content and thematic analyses.Results:Three themes were identified:symptom experience,self-coping patterns,and existing obstacles.During the early stages of chemotherapy,patients reported a higher frequency of unpleasant symptoms and recognized these symptoms earlier in the treatment course.Patients in the early stages primarily relied on external support to cope with symptoms,while those in the later stages adopted self-care strategies.Several challenges related to unpleasant symptoms were observed,which appeared to correlate with the self-coping patterns employed.Conclusion:Patients with pancreatic cancer undergoing chemotherapy experience a complex and diverse range of symptoms,with varying coping patterns at different stages of treatment.Symptom management during chemotherapy presents significant challenges.Healthcare providers should improve the ongoing monitoring of symptoms post-chemotherapy.By linking patients’symptom experiences and self-coping patterns at different stages of chemotherapy to their specific challenges,personalized symptom management strategies can be developed to enhance care quality.
文摘Objective:To explore the self-management experiences and outpatient nursing needs of intestinal stoma patients during the post-discharge transition period,in order to provide a basis for scientific decision-making in patient self-care and improvements in specialized stoma outpatient services.Methods:Using purposive sampling,13 colorectal cancer patients in the post-discharge transition period who had undergone intestinal stoma surgery were selected from a tertiary hospital in Shandong Province between November 2024 and March 2025.Semi-structured interviews were conducted,and data were analyzed using Colaizzi’s seven-step method to extract themes.Results:Three core themes were identified:challenges in self-management during the transition period,outpatient nursing needs during the transition period,and gaps in doctor-patient information continuity.Conclusion:Future efforts should focus on high-risk groups of stoma patients during the transition period by building intelligent and systematic outpatient guidance and support systems to improve their quality of life.
基金supported by the STI 2030-Major Projects(2021ZD0200500).
文摘Background:Adverse childhood experiences(ACEs)are a significant issue in adolescent health due to their robust correlation with deficits in executive functions(EF)and health risk behaviors(HRBs).This study aimed to examine the association between ACEs and a range of HRBs,including substance use,sexual risk behavior,suicidal ideation,physical inactivity,and violence.Methods:This cross-sectional study used self-administered questionnaire and cluster sampling in seven junior high schools in Samarinda,Indonesia,with a sample size of 534 students.Data analysis using descriptive statistics,the Chi-square test,the independent t-test,ANOVA,binary logistic regression,and mediation analysis with macro-PROCESS.Results:The most common ACEs were community violence(68.0%),physical neglect(52.8%),psychological/emotional abuse(52.6%),physical abuse(50.4%),and peer bullying(45.9%).Adolescents with more than five ACEs showed significantly higher involvement in smoking/vaping(67.9%),suicidal ideation(75.2%),sexual risk behavior(57.7%),bullying(64.3%),and physical fighting(59.7%)(p<0.001).ACEs were significantly correlated with EF deficits(r=0.471,p<0.01)and HRB(r=0.578,p<0.01).Regression analysis confirmed that ACEs predicted EF deficits(β=0.466,p<0.001)and HRB(β=0.469,p<0.001),with EF deficits partially mediating this relationship(β=0.107,95%CI[0.045,0.094]).In addition,two subdomains of EF deficits,self-motivation(β=0.042)and self-regulation of emotion(β=0.032),significantlymediated the relationship between ACEs and HRBs.Conclusion:These findings suggest an important role for EF deficits in linking childhood adversity to engagement in risky behaviors.Addressing ACEs and EF deficits(self-motivation and self-regulation of emotion)through early intervention may be important in reducing long-term health risks among Indonesian adolescents.
基金support of the SGCC Science and Technology Project“Cost Analysis,Market Bidding Mechanism Research and Validation of New Power Sys-tem Transformation under a Diversified Value System”(1400-202357380A-2-3-XG)for this article.
文摘With the intensifying global climate crisis,carbon emissions trading has emerged as a crucial market-based instrument for emissions reduction,attracting significant attention from government agencies and academia worldwide.As of January 2024,28 carbon trading markets have been established globally,encompassing approximately 17%of global greenhouse gas emissions and serving approximately 1/3 of the global population.With various nations setting carbon neutrality targets and delineating carbon reduction pathways,the con-struction,operation,and regulatory frameworks of carbon markets are becoming increasingly refined and comprehensive.This study elucidates the importance and necessity of establishing carbon markets from the perspective of energy system transformation and sus-tainable economic development.Second,it provides a comparative analysis of the operational mechanisms,trading scales,and emission reduction outcomes of major carbon markets in the European Union,United States,and New Zealand,systematically summarizing their development processes and recent advancements.Finally,this study addresses issues and challenges in the construction of China’s carbon market.Drawing on the successful experiences of leading global carbon markets in institutional design and market operations,we pro-pose development strategies and recommendations for a carbon market with Chinese characteristics.These strategies are intended to align with international standards while meeting China’s national conditions,thereby contributing insights into the global carbon market trading system.
文摘Wireless local area networks(WLANs)have witnessed rapid growth in the past 20 years,with maximum throughput as the key tech⁃nical objective.However,quality of experience(QoE)remains the primary concern for wireless network users.We point out that poor QoE is the most challenging issue in current WLANs and further analyze the key technical problems that cause poor QoE in WLANs,including fully distributed networking architectures,chaotic random access,awkward“high capability”issues,coarse-grained quality of service(QoS)archi⁃tectures,ubiquitous and complicated interference,“no place”for AI issues,and heavy burden of standard evolution.To the best of our knowl⁃edge,this is the first work to point out that poor QoE is the most challenging problem in current WLANs,and the first to systematically ana⁃lyze the technical problems that cause poor QoE in WLANs.We strongly suggest that achieving high experience(HEX)be the key objective of the next-generation WLANs.
文摘Learning from the wisdom and insights of others remains one of the most effective paths to progress.This is the driving force behind our commitment to experience sharing.The March/April issue features three renowned international standardization experts who share their journeys,the strategic"hows and whys"of global participation,and the critical role of stakeholder engagement in shaping the future of the industry.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB34030000)the National Natural Science Foundation of China(Nos.11927901 and 12475133)+1 种基金the Youth Team Program in Basic Research Fields Stably Supported by the Chinese Academy of Sciences(No.YSBR-088)the Western Light Project of the Chinese Academy of Sciences。
文摘Heavy-ion collisions(HICs)is a unique experimental tool for investigating the properties of nuclear matter under extreme conditions in the laboratory.At HIRFL-CSR energies,HICs can create nuclear matter with 2-3 times the saturation density(ρ_(0)).The HIRFL-CSR external-target experiment(CEE)is a large-acceptance spectrometer designed to explore frontier topics in high-energy nuclear physics,such as the QCD phase structure and nuclear matter equation of states.In this letter,we introduce simulation and analysis software for the CEE experiment(CeeROOT).Based on the CEE conceptual design and CeeROOT software,the configurations of its subdetectors were optimized by considering foreseeable physical constraints.The final detector layout of the CEE spectrometer and its acceptances were validated through simulations of U+U collisions at 500 MeV/u and pp collisions at 2.8 GeV,which demonstrated that the CEE experiment will serve as a detector with wide acceptance and multi-particle identification capabilities for studying high-energy nuclear physics topics at HIRFL-CSR energies with pp,pA,and A A collisions.
基金funded by grants from the National Natural Science Foundation of China (31800314,32370239,U160323)the foundation of South China Botanical Garden,Chinese Academy of Sciences (QNXM-06)to SYthe Doctoral Research Foundation of China West Normal University (412994)。
文摘Transitioning from outcrossing to self-fertilization is a widespread reproductive strategy in plants,especially in environments where pollination is limited.Despite its prevalence,this transition has rarely been examined using transplant experiments,and previous studies have overlooked the contribution of the male parent in elucidating mating diversity.In this study,six transplanted populations were generated to investigate the relationship of the pollination environment with plant mating patterns and fecundity in Primula oreodoxa,a species that exhibits both distyly(predominantly outcrossing)and homostyly(predominantly selfing),based on data from 3582 individuals and 11 SSR markers.Homostylous plants had fruit and seed sets comparable to those of distylous plants at lower elevations but exhibited a clear reproductive advantage at higher elevations,particularly compared with the S morph.As elevation increased,the populational selfing rates increased,and the genetic diversity among the progeny was reduced.Furthermore,the visitation frequency of long-tongued pollinators was negatively and positively correlated with the selfing rate and number of mates,respectively,in the L and S morphs.In contrast,short-tongued pollinator visitation showed opposite correlations with the selfing rate and number of mates in homostylous morphs.In most populations,individuals functioned consistently as both female and male,and mating occurred randomly,suggesting a breakdown of the distyly polymorphism.Overall,our results provide experimental validation of the reproductive advantages of homostyly at high elevations by revealing that pollinator visitation shapes the selfing rate and mating diversity within populations,potentially driving the divergence of mating systems along environmental gradients.
基金Ministry of Research,Innovation and Digitization,CCCDI-UEFISCDI,Grant/Award Number:PN-IV-P7-7.1-PED-2024-1578,within PNCDI Ⅳ.
文摘Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.
基金the National Natural Science Foundation of China for support under grant No.12305037the Fundamental Research Funds for the Central Universities under grant No.2023NTST017。
文摘The Zeeman effect,a fundamental quantum phenomenon,demonstrates the interaction between magnetic fields and atomic systems.While precise spectroscopic measurements of this effect have advanced significantly,there remains a lack of simple,visually accessible demonstration for educational purposes.Here,we present a low-cost experiment that allows for direct visual observation of the Zeeman effect.Our setup involves a flame containing sodium(from table salt)placed in front of a sodium vapor lamp.When a magnetic field is applied to the flame,the shadow cast by the flame noticeably lightens,providing a clear,naked-eye demonstration of the Zeeman effect.Furthermore,we conduct two quantitative experiments using this setup,examining the effects of varying magnetic field strength and sodium concentration.This innovative approach not only enriches the experimental demonstration for teaching atomic physics at undergraduate and high school levels but also provides an open platform for students to explore the Zeeman effect through hands-on experience.
基金Science and Technology Planning Project of Guangdong Province,2023B1212060048,Xiande Xie。
文摘Recovered samples of Jilin H5 chondrite experimentally shocked to 12-133 GPa were studied to explore the behavior of opaque minerals under shock loading using SEM-EDS,Raman spectroscopy,and TIMA.The following results were obtained.Firstly,at pressures lower than 53GPa,the opaque minerals still keep the unmelted state,while at 78 GPa and higher,FeNi metal and troilite form eutectic intergrowths occurring as disorderly fine veinlets filling the shock-induced fractures in silicate minerals.Secondly,single kamacite grains still maintain their contour at 12 GPa,but a part of brittle troilite grains was fragmented and squeezed into the shock-induced fractures within kamacite grains.At53 and 133 GPa,many more troilite fragments are poured in the kamacite interior to form disordered hybrid aggregates or to form squiggly strips,respectively.Similar phenomena are observed within single troilite grains,but the mineral squeezed into troilite grains is kamacite.Thirdly,chromite is a hard and refractory oxide mineral.When the shock pressure rises step by step from 12 to 133 GPa,the shock effect of chromite is only fragmentation.Its grain size decreases from tens of um at 53 GPa to a few um at 133 GPa.And,fourthly,native copper exhibits distinct redistribution behavior at high temperature.In Jilin samples shock-loaded to 12 GPa,copper initially located at troilite-kamacite interfaces partially transferred into small troilite grains containing fine FeNi particles.At 53 and 133 GPa,native copper preferentially transferred into larger troilite grains containing more particles of eutectic FeNi metal.
基金supported by the Key Laboratory of Clinical Evaluation Technology for Human Experience with Chinese Medicine,Science and Technology Innovation Project of Guangdong Provincial Medical Products Administration(2022ZDB06)the Jointly Funded Project by Guangzhou Science and Technology Bureau,Research Institutes and Enterprises(2024A03j0355)+1 种基金the State Key Laboratory of Traditional Chinese Medicine Syndrome"Unveiling the List and Taking on Leadership"Project(SKLKY2025C0013)the National Key Research and Development Program of China(2025YFC3507902).
文摘The development of pattern-based traditional Chinese medicine(TCM)compound preparations constitutes a core domain that represents the principle of pattern differentiation-based treatment,a hallmark of TCM.However,the field has long been constrained by scientific and regulatory challenges in animal modeling,efficacy evaluation,and clinical positioning.This article proposes a new research and development(R&D)paradigm strategically based on human use experience(HUE)and centered on the patient as the key to overcoming these bottlenecks and achieving high-quality progress.We systematically dissect the traditional problems in this field and demonstrate the pivotal role of high-quality HUE in enabling precise clinical positioning and optimizing R&D pathways(e.g.,applying for exemptions from non-clinical studies).HUE guides the implementation of the“pattern-symptom integration”model.Furthermore,we detail the implementation of the patient-centered concept throughout the process of clinical trial design,collection of patients’experience data,clinical outcome assessment,and benefit-risk assessment.The integrative application of artificial intelligence in the R&D of pattern-based TCM drugs is also specifically explored.By synthesizing the“TCM theory,HUE,and clinical trials”evidence system,this article aims to provide a systematic strategic framework for establishing an R&D pathway that adheres to the intrinsic principles of TCM while simultaneously meeting modern scientific standards.
基金Supported by Undergraduate Higher Education Teaching Quality and Reform Projects of Guangdong Province(Yuejiao Gao Han[2024]No.9,Yuejiao Gao Han[2024]No.30)Guangdong Basic and Applied Basic Research Foundation(2023A1515110973)+1 种基金Guangdong Provincial Young Innovative Talents Project of General Colleges and Universities(2023KQNCX089)Quality Engineering and Teaching Reform Projects of Zhaoqing University(zlgc202239,zlgc202207,zlgc2024005,zlgc2024038).
文摘To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was structured around a project titled"Influenza Virus Analysis",comprising four progressive modules:database utilization and information retrieval,sequence alignment and phylogenetic analysis,functional and structural prediction,and omics data analysis.These modules were integrated into a coherent research workflow that connected fragmented knowledge and technical skills.During implementation,flipped classroom and group collaboration methods were employed,alongside the establishment of a diversified assessment system emphasizing process evaluation.Teaching practice indicates that the reform effectively enhances students professional application skills,learning experience,and scientific literacy,facilitating a shift from"tool operation"to"problem-solving"capabilities.This study provides a reference model for the reform of bioinformatics experimental teaching in local universities.
文摘The subject matter of this paper is the thesis on the underdetermination of theory by experience,in the local account due to Duhem and in the global version due to Quine.This thesis has significant implications concerning some epistemic uncertainty about the accuracy of the tested predictions of theories.We find this thesis plausible,though more feasible,limited to physical theories,as in Duhem’s approach.We examine the thesis of the impossibility of crucial experiments that Duhem finds implied by his thesis on empirical indeterminacy,as well as the thesis of the possibility of empirically equivalent theories that are logically incompatible,which Quine also finds linked to his thesis on empirical indeterminacy.From a conceptualist approach that acknowledges the abstract character of physical concepts and the idealized nature of physical laws,and assuming Hanson’s thesis on the theory laden of scientific observation,we conclude that the anterior Duhem’s thesis is sound,although the preceding Quine’s thesis does not seem viable.
