Purpose Cancer predisposition syndromes are genetic disorders that significantly raise the risk of developing malignancies.Although the malignant manifestations of cancer predisposition syndromes are well-studied,reco...Purpose Cancer predisposition syndromes are genetic disorders that significantly raise the risk of developing malignancies.Although the malignant manifestations of cancer predisposition syndromes are well-studied,recognizing their non-malignant features is crucial for early diagnosis,especially in children and adolescents.Methods A comprehensive literature search was conducted using the PubMed database,focusing on non-malignant manifestations of cancer predisposition syndromes in children and adolescents.Key sources included the Clinical Cancer Research pediatric oncology series and ORPHANET.Studies that described clinical signs and symptoms affecting specific organ systems were included.Results Non-malignant dermatological features often serve as early indicators of cancer predisposition syndromes,including café-au-lait spots in Neurofibromatosis Type 1 and facial angiofibromas in Tuberous Sclerosis Complex.Neurological and developmental anomalies such as cerebellar ataxia in ataxia-telangiectasia and intellectual disabilities in neurofibromatosis type 1 and tuberous sclerosis complex are significant indicators.Growth and metabolic anomalies are also notable,including overgrowth in Beckwith–Wiedemann syndrome and growth hormone deficiency in neurofibromatosis Type 1.In addition,facial anomalies,ocular manifestations,hearing issues,and thyroid anomalies are prevalent across various cancer predisposition syndromes.For instance,hearing loss may be significant in neurofibromatosis Type 2,while thyroid nodules are common in PTEN hamartoma tumor syndrome and DICER1 syndrome.Cardiovascular,abdominal,musculoskeletal,pulmonary,genitourinary manifestations,and prenatal deviations further complicate the clinical picture.Conclusions Recognizing non-malignant features of cancer predisposition syndromes is essential for early diagnosis and management.This organ-specific overview furthers awareness among healthcare providers,facilitating timely genetic counseling,surveillance programs,and preventive measures,ultimately improving patient outcomes.展开更多
We conducted a systematic review andmeta-analysis to determine the prevalence of depression among elderly people living with HIV.We searched electronic databases and included 12 observational studies that reported on ...We conducted a systematic review andmeta-analysis to determine the prevalence of depression among elderly people living with HIV.We searched electronic databases and included 12 observational studies that reported on depression among people who were 50 years of age or older and had HIV.The studies were mostly hospital-based and fromWestern and African countries.They included a total of 5868 older peoplewith HIV,ofwhom 1667 had depression.Pooled prevalence of depression was 28%with heterogeneity of 95.2%.Prevalence ranged from 14.5%in the Netherlands to 42.4%in South Africa.Although therewas asymmetry in the funnel plot,the Egger’s test showed no significant publication bias.Our meta-analysis found a high burden of depression among older people with HIV.Comprehensive health services addressing psychosocial needs and interventions to prevent and treat depression are needed,especially in community settings.Healthcare providers and policymakers should address the prevalence of depression in such communities.展开更多
基金The research of KM on pediatric cancer predisposition is supported by Deutsche Krebshilfe(70115888)Deutsche Forschungsgemeinschaft(KU3764/3-1)intramurale Forschungsförderung,University of Augsburg,Germany.FMC’s research on rhabdoid tumor disposition is supported by Deutsche Krebshilfe 70113981.
文摘Purpose Cancer predisposition syndromes are genetic disorders that significantly raise the risk of developing malignancies.Although the malignant manifestations of cancer predisposition syndromes are well-studied,recognizing their non-malignant features is crucial for early diagnosis,especially in children and adolescents.Methods A comprehensive literature search was conducted using the PubMed database,focusing on non-malignant manifestations of cancer predisposition syndromes in children and adolescents.Key sources included the Clinical Cancer Research pediatric oncology series and ORPHANET.Studies that described clinical signs and symptoms affecting specific organ systems were included.Results Non-malignant dermatological features often serve as early indicators of cancer predisposition syndromes,including café-au-lait spots in Neurofibromatosis Type 1 and facial angiofibromas in Tuberous Sclerosis Complex.Neurological and developmental anomalies such as cerebellar ataxia in ataxia-telangiectasia and intellectual disabilities in neurofibromatosis type 1 and tuberous sclerosis complex are significant indicators.Growth and metabolic anomalies are also notable,including overgrowth in Beckwith–Wiedemann syndrome and growth hormone deficiency in neurofibromatosis Type 1.In addition,facial anomalies,ocular manifestations,hearing issues,and thyroid anomalies are prevalent across various cancer predisposition syndromes.For instance,hearing loss may be significant in neurofibromatosis Type 2,while thyroid nodules are common in PTEN hamartoma tumor syndrome and DICER1 syndrome.Cardiovascular,abdominal,musculoskeletal,pulmonary,genitourinary manifestations,and prenatal deviations further complicate the clinical picture.Conclusions Recognizing non-malignant features of cancer predisposition syndromes is essential for early diagnosis and management.This organ-specific overview furthers awareness among healthcare providers,facilitating timely genetic counseling,surveillance programs,and preventive measures,ultimately improving patient outcomes.
文摘We conducted a systematic review andmeta-analysis to determine the prevalence of depression among elderly people living with HIV.We searched electronic databases and included 12 observational studies that reported on depression among people who were 50 years of age or older and had HIV.The studies were mostly hospital-based and fromWestern and African countries.They included a total of 5868 older peoplewith HIV,ofwhom 1667 had depression.Pooled prevalence of depression was 28%with heterogeneity of 95.2%.Prevalence ranged from 14.5%in the Netherlands to 42.4%in South Africa.Although therewas asymmetry in the funnel plot,the Egger’s test showed no significant publication bias.Our meta-analysis found a high burden of depression among older people with HIV.Comprehensive health services addressing psychosocial needs and interventions to prevent and treat depression are needed,especially in community settings.Healthcare providers and policymakers should address the prevalence of depression in such communities.
