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The Effect of a Psycho-Educational Intervention on Quality of Life of Patients with Advanced Lung Cancer Undergoing Chemotherapy 被引量:1
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作者 Yanli Zhao Ruifang Zhu 《Open Journal of Nursing》 2015年第10期843-847,共5页
Objective: Cancer patients undergoing chemotherapy commonly experience depression and anxiety, which, along with adverse effects of chemotherapy, inevitably compromise quality of life (QOL) of the patients. The aim of... Objective: Cancer patients undergoing chemotherapy commonly experience depression and anxiety, which, along with adverse effects of chemotherapy, inevitably compromise quality of life (QOL) of the patients. The aim of this study was to investigate the effect of a psycho-educational intervention on the quality of life (QOL) of patients with advanced lung cancer undergoing chemotherapy. Methods: Two hundred in-patients with unresectable advanced lung cancer undergoing chemotherapy in Shanxi Cancer Hospital from January to October 2013 were randomized into the intervention group (n = 100) and the control group (n = 100). Patients in the intervention group received a purposely designed and nurse-delivered psycho-educational intervention in addition to routine caring and chemotherapy, whereas those in the control group underwent chemotherapy and routine caring only. QOL of patients was assessed according to QOL instrument for lung cancer (QLICP-LU). The impact of the psycho-educational intervention on QOL was analyzed using independent-sample t test and χ2 test. Results: The psychological, physical, and social function, and the overall QOL scores were significantly improved in patients who received the psycho-educational intervention compared with those in the control group. Conclusions: A nurse-delivered psycho-educational intervention is a useful strategy to improve QOL of patients with advanced lung cancer undergoing chemotherapy. 展开更多
关键词 psychoLOGICAL INTERVENTION psycho-Educational INTERVENTION LUNG Cancer Quality of Life
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The Effect of a Psycho-Educational Program on Psychiatric Symptoms, Drug Attitude and Treatment Satisfaction of Patients with Schizophrenia
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作者 Yueren Zhao Yuko Yasuhara +5 位作者 Tetsuya Tanioka Sakiko Sakamaki Masahito Tomotake Beth King Rozzano C. Locsin Nakao Iwata 《Open Journal of Psychiatry》 2015年第3期229-237,共9页
The purpose of this study was to determine the effect of a Comprehensive Psycho-Educational Approach and Scheme Set (COMPASS) for patients with schizophrenia who were treated with risperidone long-acting injectable (R... The purpose of this study was to determine the effect of a Comprehensive Psycho-Educational Approach and Scheme Set (COMPASS) for patients with schizophrenia who were treated with risperidone long-acting injectable (RLAI), on their psychiatric symptoms, drug attitudes, and treatment satisfaction levels. Participants were sixty-five patients at thirteen hospitals in Japan who met ICD-10 F2 criteria for schizophrenia or schizo-affective disorder and were treated with RLAI. A correlational study design was used to measure the effect of the COMPASS on the psychiatric symptoms, drug attitudes, and treatment satisfaction levels of patients treated with RLAI. Using the following evaluation indicators: The Subjective Satisfaction to Treatment Scale (SSTS), Brief Psychiatric Rating Scale (BPRS), Global Assessment of Functioning (GAF), Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS), and Drug Attitude Inventory-10 (DAI-10), measurements were taken at the beginning of the program (baseline), at the end of the program, and six months after (endpoint). Data analysis included descriptive statistics, Mann-Whitney U test or Wilcoxon signed-rank test, and Spearman’s rank correlation coefficient. Significant differences were observed in BPRS total (p < 0.001), sub-scales of BPRS positive (p < 0.001), BPRS negative (p < 0.01), BPRS affective (p < 0.01), and GAF (p < 0.001). However, there was no significant change in subscale of BPRS manic, DAI-10, DIEPSS, or SSTS but significant positive correlations were found between SSTS and DAI-10 and GAF at baseline;a negative correlation was found between SSTS and BPRS. The findings of the study suggested the benefit of using the COMPASS in conjunction with RLAI to decrease patients’ psychiatric symptomatology and improve treatment satisfaction. In addition, patient satisfaction was found to be an important factor to be considered by the psychiatrist. 展开更多
关键词 SCHIZOPHRENIA LONG-ACTING Injection psycho-EDUCATION COMPASS (Comprehensive psycho-Educational Approach and Scheme Set) ADHERENCE SATISFACTION Level
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Expectations of Patients with a Diagnosis of Breast Cancer When Meeting the Psycho-Oncologist: Beyond the Assistance of the Oncologist
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作者 David Ogez Philippe de Timary +7 位作者 Martine Berlière Leila Rokbani Maud Colmant Frédérique Lieutenant Guillaume Gascard Catherine Denoel Aline van Maanen Emmanuelle Zech 《Open Journal of Medical Psychology》 2014年第5期315-324,共10页
Objective: Cancer patients consider the oncologist as their main resource insofar as the medical needs generally take precedence over psychological needs. Nevertheless, the psychological intervention is also important... Objective: Cancer patients consider the oncologist as their main resource insofar as the medical needs generally take precedence over psychological needs. Nevertheless, the psychological intervention is also important. The systematic consultation implemented in our hospital after a diagnosis of cancer is a manner to answer patients’ psychological needs. In a survey, we assessed the satisfaction and expectations of the patients about this consultation. Methods: One year after a diagnosis of breast cancer, 104 patients answered a retrospective questionnaire assessing: socio- demographic data, cancer medical information, systematic consultation satisfaction, patients’ expectations for a systematic intervention, and patients’ characteristics who began a psychological follow-up. Results: 72.1% of the patients were satisfied with having the opportunity to consult a psychologist during a systematic consultation after cancer diagnosis. Their expectations were to have opportunities of emotional expression, reassurance, obtaining additional medical information, talking about their fear over additional treatments, and identifying further support. 28.8% of the patients re-contacted the psychologist for further help after the systematic consultation. They were significantly younger (p < 0.001) than the others. Conclusions: Besides the importance of support by medical specialists [1], offering the opportunity to breast cancer patients to discuss inner feelings and treatment expectations during a systematic psychological consultation was useful for most of them. About one third of the patients asked for a further consultation with a psychologist after a first systematic consultation, especially younger patients. This stressed the importance of the role of psychologists for psycho-social support of the patient after cancer treatment. 展开更多
关键词 psycho-ONCOLOGY Screening CONSULTATION Systematic psychoLOGICAL FOLLOW-UP Breast Cancer Survey
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Reporting and understanding the safety and adverse effect profile of mobile apps for psychosocial interventions:An update 被引量:3
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作者 Farooq Naeem Nadeem Gire +5 位作者 Shuo Xiang Megan Yang Yumeen Syed Farhad Shokraneh Clive Adams Saeed Farooq 《World Journal of Psychiatry》 SCIE 2016年第2期187-191,共5页
Recent years have seen a rapidly increasing trend towards the delivery of health technology through mobile devices.Smartphones and tablet devices are thus becoming increasingly popular for accessing information and a ... Recent years have seen a rapidly increasing trend towards the delivery of health technology through mobile devices.Smartphones and tablet devices are thus becoming increasingly popular for accessing information and a wide range of services,including health care services.Modern mobile apps can be used for a variety of reasons,ranging from education for the patients and assistance to clinicians to delivery of interventions.Mobile phone apps have also been established to benefit patients in a scope of interventions across numerous medical specialties and treatment modalities.Medical apps have their advantages and disadvantages.It is important that clinicians have access to knowledge to make decisions regarding the use of medical apps on the basis of risk-benefit ratio.Mobile apps that deliver psycho social interventions offer unique challenges and opportunities.A number of reviews have highlighted the potential use of such apps.There is a need to describe,report and study their side effects too.The adverse effects associated with these apps can broadly be divided into:(1)those resulting from the security and safety concerns;(2)those arising from the use of a particular psycho social intervention;and(3)those due to the interaction with digital technology.There is a need to refine and reconsider the safety and adverse effects in this area.The safety profile of a mobile PSI app should describe its safety profile in:(1)privacy and security;(2)adverse effects of psychotherapy;and(3)adverse effects unique to the use of apps and the internet.This is,however,a very new area and further research and reporting is required to inform clinical decision making. 展开更多
关键词 MOBILE psycho social Side effects Health Media Security PRIVACY
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Decoding psychosis:from national genome project to national brain project 被引量:3
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作者 Liya Sun Manfei Xu +3 位作者 Yongyong Shi Yifeng Xu Jinghong Chen Lin He 《General Psychiatry》 CAS CSCD 2022年第4期214-223,共10页
The mind has puzzled humans for centuries,and its disorders,such as psychoses,have caused tremendous difficulties.However,relatively recent biotechnological breakthroughs,such as DNA technology and neuroimaging,have e... The mind has puzzled humans for centuries,and its disorders,such as psychoses,have caused tremendous difficulties.However,relatively recent biotechnological breakthroughs,such as DNA technology and neuroimaging,have empowered scientists to explore the more fundamental aspects of psychosis.From searching for psychosis-causing genes to imaging the depths of the brain,scientists worldwide seek novel methods to understand the mind and the causes of its disorders.This article will briefly review the history of understanding and managing psychosis and the main findings of modern genetic research and then attempt to stimulate thought for decoding the biological mechanisms of psychosis in the present era of brain science. 展开更多
关键词 BREAKTHROUGH SIS psycho
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Environmental and Psycho-social Factors Related to Prostate Cancer Risk in the Chinese Population:a Case-control Study 被引量:5
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作者 LI Mei Ling LIN Ji +11 位作者 HOU Jian Guo XU Lei CUI Xin Gang XU Xing Xing YU Yong Wei HAN Xue WANG Guo Min GUO Jian Ming XU Dan Feng THOMPSON Timothy C CAO Guang Wen ZHANG Hong Wei 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2014年第9期707-717,共11页
Objective To study the risk environmental and psycho-social factors associated to prostate cancer (PCa) in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Info... Objective To study the risk environmental and psycho-social factors associated to prostate cancer (PCa) in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (95% CI) for relationship between lifestyle, eating habits and psycho-social factors with PCa risk. Results Green vegetables and green tea were associated with a decreased risk of PCa (0R=0.39, 95% CI: 0.28-0.53; 0R=0.59, 95% Cl: 0.40-0.87, respectively). Family history of PCa (0R=7.16, 95% CI: 2.01-25.49), history of prostate diseases (0R=2.28, 95% Cl: 1.53-3.41), alcohol consumption (0R=1.97, 95% CI: 1.33-2.90), red meat consumption (0R=1.74, 95% CI: 1.20-2.52), barbecued (0R=2.29, 95% CI: 1.11-4.73) or fried (0R=2.35, 95% CI: 1.24-4.43) foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks (0R=1.61, 95% CI: 2.00-2.59), marital separation (0R=1.94, 95% CI: 1.29-2.91), self-contained suffering {0R=2.37, 95% CI: 1.58-3.55), and high sensitivity to the personal comments (0R=1.73, 95% CI: 1.18-2.54) were related to PCa. Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population. 展开更多
关键词 Case-control study LIFESTYLE Dietary factors psycho-social factors Prostate cancer
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Promising medical treatment for childhood psycho-cognitive problems
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作者 Parvaneh Karimzadeh Sepideh Tabarestani 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第21期1663-1667,共5页
Subclinical electroencephalogram discharges in children with psycho-cognitiVe problems are not uncommon. However, the clinical importance and relationship to cognitive deficits, as well as indications for medical trea... Subclinical electroencephalogram discharges in children with psycho-cognitiVe problems are not uncommon. However, the clinical importance and relationship to cognitive deficits, as well as indications for medical treatment, are not well understood. Transient cognitive impairment, which accompanies electroencephalogram discharges, could negatively influence cognitive abilities over time. Studies have suggested that treatment with antiepileptic drugs normalizes electroencephalogram results, thereby preventing electrical paroxysmal discharges that could be harmful to the developing brain. Physicians should attempt to differentiate between corresponding factors, such as subtle seizures, nature of underlying etiology, stable cognitive deficits, seizure-inducing effects, and potential side effects of antiepileptic drugs prior to initiation of medical treatment for definitive diagnosis of transient cognitive impairment and its consequences. Therefore appropriate criteria for patient selection and proper guidelines for medical therapy, should be addressed in future studies. 展开更多
关键词 psycho-behavioral problems cognitive deficits subclinical epileptiform discharges antiepileptic drugs
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Computer Administering of the Psychological Investigations: Set-Relational Representation
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作者 Krasimir Yordzhev Ivelina Peneva 《Open Journal of Applied Sciences》 2012年第2期110-114,共5页
Computer administering of a psychological investigation is the computer representation of the entire procedure of psychological assessments—test construction, test implementation, results evaluation, storage and main... Computer administering of a psychological investigation is the computer representation of the entire procedure of psychological assessments—test construction, test implementation, results evaluation, storage and maintenance of the developed database, its statistical processing, analysis and interpretation. A mathematical description of psychological assessment with the aid of personality tests is discussed in this article. The set theory and the relational algebra are used in this description. A relational model of data, needed to design a computer system for automation of certain psychological assessments is given. Some finite sets and relation on them, which are necessary for creating a personality psychological test, are described. The described model could be used to develop real software for computer administering of any psychological test and there is full automation of the whole process: test construction, test implementation, result evaluation, storage of the developed database, statistical implementation, analysis and interpretation. A software project for computer administering personality psychological tests is suggested. 展开更多
关键词 COMPUTER Administering COMPUTER Testing COMPUTER psycho DIAGNOSTIC Mathematical Modeling SET Theory RELATIONAL ALGEBRA DATABASES
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Psycho-medical aspects on migrants health of III? world pediatric surgical patients
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作者 Andreas Fette Kurosh Paya Istvan Szilard 《Health》 2011年第2期106-109,共4页
The constantly expanding world wide mobility and globalization within the pediatric community puts new demands on pediatric surgical health care systems worldwide. Forcing carers to pay attention not only on their bes... The constantly expanding world wide mobility and globalization within the pediatric community puts new demands on pediatric surgical health care systems worldwide. Forcing carers to pay attention not only on their best surgical and medical performance like in the past. In contrary, they are forced to pay much more attention on psycho-medical aspects like finance, rehabilitation, socialization and integration, culture, management and logistics, health edu-cation and language skills. Then, according to our opinion these aspects should be considered as Post Traumatic Stress Disorder (PTSD)-like syndrome and treated accordingly. Then handling this problem succesfully, would be essential for the future survival of any health care system. 展开更多
关键词 Developing World Children HEALTH CARE psycho-Medical ASPECTS PEDIATRIC Surgery
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Impact of Relaxation and Group Psycho-Education on Health Outcomes Using Integrated Care Models and Quality Improvement
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作者 Martha Okafor Victor Ede +4 位作者 Rosemary Kinuthia Debbie Strotz Cathryn Marchman Scott Weeks David Satcher 《Open Journal of Preventive Medicine》 2014年第12期887-896,共10页
The purpose of this Integrated Care Practice Change and Quality Improvement (ICPCQI) initiative was to evaluate the impact of wellness and relaxation and group psycho-education on health out-comes in an integrated car... The purpose of this Integrated Care Practice Change and Quality Improvement (ICPCQI) initiative was to evaluate the impact of wellness and relaxation and group psycho-education on health out-comes in an integrated care setting. Individuals diagnosed with mental illness and a co-occurring chronic medical condition participated in the ICPCQI initiatives which were run by peer support and wellness experts in an integrated care setting over the one-year project implementation period. Evaluation of outcome measures revealed an overall decline of 8.3% (p < 0.0001) and 7.3% (p < 0.0001) in the average systolic and diastolic blood pressure respectively. There was a 12.3% (p = 0.02) reduction on the average PHQ-9 scores. GAD-7 (p = 0.9) scores had a mean reduction of 1.5%. These preliminary results suggest that the evidence-based ICPCQI initiatives positively impact health outcomes among individuals with mental illness and chronic medical conditions. 展开更多
关键词 Integrated Care RELAXATION GROUP psycho-EDUCATION HEALTH Outcomes Quality Improvement Peer SPECIALIST WELLNESS Primary Healthcare Behavioral HEALTH
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Dependence of Cognitive Processes from the Individual Psychophysiological Characteristics of Upper-School Students of a Special Lyceum
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作者 Viacheslav Ivanovich Hasnulin Tatiana Ivanovna Riabichenko +2 位作者 Anna Vlfdimirovna V. Hasnulina Galina Aleksandrovna Skosyreva Yulia Nikolaevna Patrusheva 《Open Journal of Medical Psychology》 2014年第3期185-188,共4页
The enrichment by highly information load of the school educational process, which leads in severe environment to psycho-emotional stress, confirms the necessity of studying the psycho-emotional and physiological stab... The enrichment by highly information load of the school educational process, which leads in severe environment to psycho-emotional stress, confirms the necessity of studying the psycho-emotional and physiological stability of the senior schoolboys to information educational stress in rugged climate/geographic regions of Siberia. Observed were the 110 teenagers, the inhabitants of Novosibirsk, the students of 9th-10th classes of the special lycée. Clinical, psychological, psychophysiological, biochemical and hormonal methods of observation were used. It was shown that efficiency of the modern information-enriched educational process defines a complex of individual adaptive characteristics of an organism, including lateral phenotype of the prevalence of cerebral hemispheres, the stability of psychophysiological response, minimization of painful reaction to sharp changes of the factors of nature—meteosensitivity, and also the belonging to chronotypes (morning or evening). These features form the basis of stability of the young organism to the educational information stress and to the action of rugged climate-meteorological and biorhytmological factors, aggravating this stress. 展开更多
关键词 psycho-Emotional STRESS Meteosensitivity Functions of HEMISPHERES of Brain Informational EDUCATIONAL STRESS Efficiency of Education Process
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Socio-Demographic Factors Associated with Psychoactive Substance Use among Commercial Motorcycle Operators in Kano, Nigeria
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作者 Mustapha Ibrahim Gudaji Zahraddeen Garba Habib 《Open Journal of Psychiatry》 2016年第1期76-85,共10页
Background: Psychoactive substance use was common among commercial motorcycle operators. Studies had shown that there were some socio-demographic factors which were commoner among commercial motorcycle operators ... Background: Psychoactive substance use was common among commercial motorcycle operators. Studies had shown that there were some socio-demographic factors which were commoner among commercial motorcycle operators who used psychoactive substances. However, this was not explored among commercial motorcycle operators in Kano, North Western Nigeria. Aim: The aim of the study was to determine the socio-demographic factors associated with psychoactive substance use among motorcycle operators in Kano, Northwestern Nigeria. Methods: It was a cross-sectional study. Instrument used for data collection included socio-demographic questionnaire and World Health Organisation Student Drug Use Questionnaire. Data analysis was done using Statistical Package for Social Sciences (SPSS) 16th edition. Results: Commercial motorcycle operators who used substances were found to be of younger age group (X<sup>2</sup> = 10.9, P < 0.001), single (X<sup>2</sup> = 4.3, P = 0.034) and had a father who used tobacco (X<sup>2</sup> = 4.28, P = 0.04). Participants who were single were more likely to use inhalants (X<sup>2</sup> = 21.06, P =0.001), opiates (X<sup>2</sup> = 11.82, P = 0.012), cannabis (X<sup>2</sup> = 5.12, P = 0.028) and stimulants (X<sup>2</sup> = 5.12, P = 0.028) compared to those who were married. Conclusion: This study found that being of younger age, being single, and having a father who smoked were significantly associated with psychoactive substance use. Participants who were singles were more likely to use inhalants, opiates, cannabis and stimulants. No relationship was observed between the age of the respondents and specific substance use. Legislations should be enacted to reduce the rate of psychoactive substance use among motorcycle operators and general population at large. 展开更多
关键词 psycho-Active Substance Sociodemographic Factors Motorcycle Operators SDUQ NIGERIA
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Analysis of Difficulties in Simultaneous Interpreting(SI) from a Psycho-linguistic Perspective
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作者 刘安琪 《海外英语》 2017年第21期146-148,共3页
Nowadays,simultaneous interpreting(SI) plays a prominent role in global communications,especially for important international affairs.This kind of interpretation delivers information in an instantaneous way without wa... Nowadays,simultaneous interpreting(SI) plays a prominent role in global communications,especially for important international affairs.This kind of interpretation delivers information in an instantaneous way without wasting extra time for language processing.Performing well in SI requires long-time training and abundant experience.Making a comprehensive categorization and analysis on the difficulties in SI on the basis of psycho-linguistic theories are the key points.Due to the distinctive features of these difficulties,corresponding suggestions will be offered to improve the efficiency in SI training and to level up the performance of SI interpreters. 展开更多
关键词 Simultaneous Interpreting(SI) difficulty analysis SI training psycho-linguistics
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Psychosocial Aspects of Male Infertility at the Service of Urology-Andrology of the Hospital of the Sino-Guinean Friendship
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作者 Alimou Diallo Thierno Oumar Diallo +3 位作者 Alpha Oumar Barry Ibrahima Bah Abdoulaye Bobo Diallo Oumar Raphiou Bah 《Open Journal of Urology》 2024年第7期400-406,共7页
Objective: Describe the psychosocial aspects of male infertility at the hospital of the Sino-Guinean Friendship. Patients and method: It is a prospective study of a descriptive type covering a period of 6 months. The ... Objective: Describe the psychosocial aspects of male infertility at the hospital of the Sino-Guinean Friendship. Patients and method: It is a prospective study of a descriptive type covering a period of 6 months. The study covered 17 patients, all received for a desire to conceive after at least one year of regular sexual intercourse without contraception. The data were collected from patient interviews using a pre-established questionnaire. Results: The average age of the patients was 32.07 years with extremes of 23 years and 42 years. During this study, 64.70% of patients were no longer participating in community ceremonies. The patients’ relationships with their spouse and family deteriorated in 52.94% and 47.06%, respectively. Conversely, relations with the family of origin remained unchanged in 70.59 percent of cases. The reduction in economic activity was by 13 patients (76.48%). Conclusion: Male infertility causes a real psychic earthquake in men with its corollaries of negative feelings. The rather complex moral repercussions of male infertility affect not only the individual, his/her partner, and family, but also economic activity. 展开更多
关键词 Male Infertility psycho-Social Aspect Psychic Earthquake
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Methodological Approaches to the Psychological Analysis of Ethnic Conflicts and Ideas of Anti-Russiam: Trauma and Trans-Generation Trnsmission
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作者 Reshetnikov Mikhail Mihailovich 《Psychology Research》 2017年第9期481-488,共8页
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Effects of Electroacupuncture Combined Psycho-intervention on Cognitive Function and Event-Related Potentials P300 and Mismatch Negativity in Patients with Internet Addiction 被引量:6
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作者 朱天民 李辉 +4 位作者 金荣疆 郑重 罗颖 叶桦 朱慧民 《Chinese Journal of Integrative Medicine》 SCIE CAS 2012年第2期146-151,共6页
Objective: To observe the effects of comprehensive therapy (CT) with electroacupuncture (EA) in combination with psycho-intervention (PI) on the cognitive function and event-related potentials (ERP), P300 and... Objective: To observe the effects of comprehensive therapy (CT) with electroacupuncture (EA) in combination with psycho-intervention (PI) on the cognitive function and event-related potentials (ERP), P300 and mismatch negativity (MMN), in patients with internet addiction (IA) for a preliminary exploration of the possible mechanism of the therapy. Metheds: One hundred and twenty patients with IA were randomly divided into three groups, and a total of 112 subjects reached the final analysis of the trial, the EA group (39 patients), the PI group (36 patients) and the CT group (37 patients). EA was applied at acupoints Baihui (GV20), Sishencong (EX-HN1), Hegu (LI4), Neiguan (PC6), Taichong (LR3) and Sanyinjiao (SP6), once every other day; PI with the cognition- behavior mode was implemented every 4 days; both EA and PI were used in the CT group. The treatment course for all patients was 40 days. Changes before and after treatment in terms of scoring by the IA self-rating scale, short-term memory capacity, short-term memory span, and the latency and amplitude of P300 and MMN in patients were observed. Results: After treatment, in all groups, the IA score was lowered significantly (P〈0.05) and scores of short-term memory capacity and short-term memory span increased significantly (P〈0.05), while the decreased IA score in the CT group was more significant than that in the other two groups (P〈0.05). ERP measurements showed that P300 latency was depressed and its amplitude raised in the EA group; MMN amplitude increased in the CT group (all P〈0.05). Cenclusien: The EA in combination with PI could improve the cognitive function of IA patients, and its mechanism might be related to the speedup of cerebral discrimination on external stimulus and the enhancement of effective resource mobilization during information processing of the brain. 展开更多
关键词 internet addiction cognitive function event-related potential ELECTROACUPUNCTURE psycho-intervention
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Improved mPFC-MTL connectivity after a psycho-physical intervention in the elderly
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《Science Foundation in China》 CAS 2015年第2期23-23,共1页
With the support by the National Natural Science Foundation of China,Prof.Li Juan’s laboratory at the Center on Aging Psychology,Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,rep... With the support by the National Natural Science Foundation of China,Prof.Li Juan’s laboratory at the Center on Aging Psychology,Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,reported plasticity of the functional connectivity between the medial prefrontal cortex(mPFC)and the medial temporal lobe(MTL)in older adults,which was published in Frontiers in Aging 展开更多
关键词 CONNECTIVITY MEDIAL psycho cortex plasticity OLDER Aging elderly GYRUS allocated
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The Physics and Psychophysics of Music
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作者 Juan G.Roederer 《Chinese Journal of Acoustics》 1995年第3期281-281,共1页
关键词 notation ACOUSTICS psycho MUSICAL SENSATION EDITION instru
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Psycho的诅咒
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作者 阿侠 《明日风尚》 2007年第3期68-68,共1页
弗洛伊德其实是个极端理想主义者,努力将自己色欲的本性压下,甘愿做一个清教徒,将所有性幻想都升华成为个案,用理性去解释内心躁动不安的非理性,这种接近告白式的心理分析方法,简直就是人类合理化自己行为的最大产物,于是Psycho花了很... 弗洛伊德其实是个极端理想主义者,努力将自己色欲的本性压下,甘愿做一个清教徒,将所有性幻想都升华成为个案,用理性去解释内心躁动不安的非理性,这种接近告白式的心理分析方法,简直就是人类合理化自己行为的最大产物,于是Psycho花了很多口水去解释Norman Bates为什么在浴室里狂斩金发美女…… 展开更多
关键词 性幻想 Bates Norman psycho 心理分析 心理变态 金斯 非人化
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基于线粒体自噬探讨补坎益离丹对围绝经期双心病大鼠模型的心脑保护作用机制 被引量:2
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作者 徐宁阳 马贤德 +1 位作者 任路 胡宇晴 《中国实验方剂学杂志》 北大核心 2025年第15期48-59,共12页
目的:基于动力蛋白相关蛋白1(Drp1)/磷酸酯酶与张力蛋白同源物(PTEN)诱导激酶1(PINK1)/帕金蛋白(Parkin)通路介导的线粒体自噬探讨补坎益离丹对围绝经期双心病的影响及机制。方法:60只大鼠随机分为空白组,模型组,西药组(单硝酸异山梨酯7... 目的:基于动力蛋白相关蛋白1(Drp1)/磷酸酯酶与张力蛋白同源物(PTEN)诱导激酶1(PINK1)/帕金蛋白(Parkin)通路介导的线粒体自噬探讨补坎益离丹对围绝经期双心病的影响及机制。方法:60只大鼠随机分为空白组,模型组,西药组(单硝酸异山梨酯7.2 mg·kg^(-1)+盐酸舍曲林18 mg·kg^(-1)),补坎益离丹低、中、高剂量组(2.59、5.18、10.35 g·kg^(-1)),每组10只。除空白组外,采用卵巢切除术(OVX)联合高脂饲养、慢性不可预知温和刺激(CUMS)和皮下多点位注射盐酸异丙肾上腺素方法制备围绝经期双心病大鼠模型。造模成功后,观察大鼠一般状态、舌象;通过旷场实验、糖水偏好实验、强迫游泳不动时间、抓力评价大鼠活体抑郁情况,心电图和超声心动图评价大鼠心功能;酶联免疫吸附测定法(ELISA)检测血清去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)水平;生化检测血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、乳酸脱氢酶(LDH)、肌酸肌酶同工酶(CK-MB)水平评估心肌损伤情况;苏木素-伊红(HE)和尼氏染色观察大鼠海马和心肌组织的病理状态;透射电镜观察海马和心肌组织线粒体自噬小体状态;蛋白免疫印迹法(Western blot)检测海马和心肌组织中Drp1、线粒体融合蛋白2(Mfn2)、视神经萎缩蛋白1(OPA1)、PINK1、Parkin、p62、微管相关蛋白轻链3B(LC3B)相对表达水平。结果:与空白组比较,模型组大鼠食水量降低,毛发暗黄,光泽度及顺滑度下降,精神萎靡,舌淡紫或暗紫,伴瘀点或瘀斑,舌下络脉紫黑,苔白滑;大鼠旷场实验各指标、抓力、糖水偏好度下降,强迫游泳不动时间增加(P<0.01);心电图和超声心动图显示,ST段明显压低,左室短轴缩短率(LVFS)、左心室射血分数(LVEF)降低(P<0.05,P<0.01);病理观察显示,海马神经元和心肌细胞数量减少,结构破坏明显;血清TC、TG、LDL-C、CK-MB、LDH、AST、ALT水平上升,HDL-C、5-HT、DA、NE水平下降(P<0.05,P<0.01);透射电镜观察到海马和心肌组织的线粒体损伤明显;海马及心肌组织中Drp1,PINK1,Parkin,p62蛋白表达水平升高,OPA1,Mfn2,LC3BⅡ/Ⅰ蛋白表达水平降低(P<0.05,P<0.01)。与模型组比较,各给药组大鼠精神状态、身体蜷缩、怕冷等症状均有所改善,舌淡紫或暗紫程度减轻;旷场实验各得分、抓力、糖水偏好度、LVFS、LVEF提高,强迫游泳不动时间缩短(P<0.05,P<0.01);心电图ST段具有显著回升(P<0.01);病理观察显示,神经细胞和心肌组织损伤改善;血清TC、TG、LDL-C、CK-MB、LDH、AST、ALT水平下降,HDL-C、5-HT、DA、NE水平上升(P<0.05,P<0.01);透射电镜观察到海马神经元和心肌细胞中线粒体损伤减轻,可见线粒体自噬小体;海马及心肌组织中Drp1、PINK1、Parkin、p62蛋白表达降低,OPA1、Mfn2、LC3BⅡ/Ⅰ蛋白表达升高(P<0.05,P<0.01)。结论:补坎益离丹可缓解围绝经期双心病大鼠的抑郁状态、脂代谢紊乱和心肌缺血损伤,其作用机制可能与抑制Drp1/PINK1/Parkin信号通路,提高线粒体自噬有关。 展开更多
关键词 围绝经期双心病 心肾阳虚 补坎益离丹 线粒体自噬 线粒体动力学 动力蛋白相关蛋白1(Drp1)/PTEN诱导激酶1(PINK1)/帕金蛋白(Parkin)通路
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