Objective. Report of first case of Protothecosis zopfii in China and causes the skin infection in the world. Method.By clinical and laboratory examinations to confirm the diagnosis and the response to treatment. By th...Objective. Report of first case of Protothecosis zopfii in China and causes the skin infection in the world. Method.By clinical and laboratory examinations to confirm the diagnosis and the response to treatment. By the review of literatures to confirm the first case of human skin infection in the world. Result.From the literatures and the clinical pictures, it is confirmed that this is the first case report of Protothecosis zopfii of skin in the world. Conclusion.The first case of Protothecosis zopfii in human being was reported and successfully treated with local infiltration of Diflucan (fluconazole) 3ml (2mg/ml)/week×4.展开更多
Background: Intestinal protothecosis is an uncommon and insidious mycotic <span>disease. Only one human case and a few rare cases in dogs have been re</span>ported. To the authors’ knowledge, intestinal p...Background: Intestinal protothecosis is an uncommon and insidious mycotic <span>disease. Only one human case and a few rare cases in dogs have been re</span>ported. To the authors’ knowledge, intestinal protothecosis has never been reported in cats. Case description: This paper describes a case of intestinal protothecosis in a nine-month-old male, Bengal cat. The cat presented because of onset <span>of haemorrhagic diarrhoea. Investigations allowed diagnosis of intestinal </span>protothecosis, confirmed by PCR test on faeces. Treatment with itraconazole did not improve the clinical signs. Treatment with nystatin was prescribed and caused improvement in the clinical signs and decreased number of pathogens seen on faecal cytology. PCR on faecal samples was negative two months after treatment, with complete resolution of symptoms. Conclusion: Infection with<i> <span>Prototheca</span></i> should be part of the list of differential diagnoses for diarrhoea in <span>cats. nystatin was effective in treating the infection in this case;this drug</span> should be considered as a first-line treatment in cats as well as in dogs, in which</span><span> </span></span><span><span><span style="font-family:"">protothecosis appears to have a poor prognosis. Although protothecosis is not considered a zoonotic disease, cases of algal infections in companion animals might be considered indicators of environmental risks for humans.展开更多
Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this g...Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this genus are rare[1].Unfortunately,due to the nonspecific clinical manifestations and limited awareness among clinicians,protothecosis is often underestimated and misdiagnosed.P.wickerhamii has been shown to exhibit low cytotoxicity tomacrophages,potentially allowing it to evade immune clearance[2].Currently,the highquality genome sequencing technology offers insights into the evolution and pathogenicity of Prototheca while also serving as a genomic resource for improved diagnosis[3].展开更多
文摘Objective. Report of first case of Protothecosis zopfii in China and causes the skin infection in the world. Method.By clinical and laboratory examinations to confirm the diagnosis and the response to treatment. By the review of literatures to confirm the first case of human skin infection in the world. Result.From the literatures and the clinical pictures, it is confirmed that this is the first case report of Protothecosis zopfii of skin in the world. Conclusion.The first case of Protothecosis zopfii in human being was reported and successfully treated with local infiltration of Diflucan (fluconazole) 3ml (2mg/ml)/week×4.
文摘Background: Intestinal protothecosis is an uncommon and insidious mycotic <span>disease. Only one human case and a few rare cases in dogs have been re</span>ported. To the authors’ knowledge, intestinal protothecosis has never been reported in cats. Case description: This paper describes a case of intestinal protothecosis in a nine-month-old male, Bengal cat. The cat presented because of onset <span>of haemorrhagic diarrhoea. Investigations allowed diagnosis of intestinal </span>protothecosis, confirmed by PCR test on faeces. Treatment with itraconazole did not improve the clinical signs. Treatment with nystatin was prescribed and caused improvement in the clinical signs and decreased number of pathogens seen on faecal cytology. PCR on faecal samples was negative two months after treatment, with complete resolution of symptoms. Conclusion: Infection with<i> <span>Prototheca</span></i> should be part of the list of differential diagnoses for diarrhoea in <span>cats. nystatin was effective in treating the infection in this case;this drug</span> should be considered as a first-line treatment in cats as well as in dogs, in which</span><span> </span></span><span><span><span style="font-family:"">protothecosis appears to have a poor prognosis. Although protothecosis is not considered a zoonotic disease, cases of algal infections in companion animals might be considered indicators of environmental risks for humans.
基金supported by the National Natural Science Foundation of China(Grant number 82172326 to W.W.).
文摘Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this genus are rare[1].Unfortunately,due to the nonspecific clinical manifestations and limited awareness among clinicians,protothecosis is often underestimated and misdiagnosed.P.wickerhamii has been shown to exhibit low cytotoxicity tomacrophages,potentially allowing it to evade immune clearance[2].Currently,the highquality genome sequencing technology offers insights into the evolution and pathogenicity of Prototheca while also serving as a genomic resource for improved diagnosis[3].
