Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this g...Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this genus are rare[1].Unfortunately,due to the nonspecific clinical manifestations and limited awareness among clinicians,protothecosis is often underestimated and misdiagnosed.P.wickerhamii has been shown to exhibit low cytotoxicity tomacrophages,potentially allowing it to evade immune clearance[2].Currently,the highquality genome sequencing technology offers insights into the evolution and pathogenicity of Prototheca while also serving as a genomic resource for improved diagnosis[3].展开更多
基金supported by the National Natural Science Foundation of China(Grant number 82172326 to W.W.).
文摘Prototheca wickerhamii,an opportunistic pathogen affecting both humans and animals,is widely distributed in the environment,including soil,mud,and water sources such as rivers.However,human infections caused by this genus are rare[1].Unfortunately,due to the nonspecific clinical manifestations and limited awareness among clinicians,protothecosis is often underestimated and misdiagnosed.P.wickerhamii has been shown to exhibit low cytotoxicity tomacrophages,potentially allowing it to evade immune clearance[2].Currently,the highquality genome sequencing technology offers insights into the evolution and pathogenicity of Prototheca while also serving as a genomic resource for improved diagnosis[3].
