Twelve previously unidentified triterpenoids(1–12)were isolated from the dichloromethane extract of Alisma orientale(A.orientale).Among these compounds,1 and 2 exhibited a rare 6/6/7/5 tetracyclic ring system,and com...Twelve previously unidentified triterpenoids(1–12)were isolated from the dichloromethane extract of Alisma orientale(A.orientale).Among these compounds,1 and 2 exhibited a rare 6/6/7/5 tetracyclic ring system,and compound 3 was lanostane,isolated from A.orientale for the first time.The structures,including relative and absolute configurations,were determined through spectroscopic methods,electronic circular dichroism(ECD),Mo2(OAc)4-induced ECD,and single-crystal X-ray diffraction.The anti-pulmonary fibrosis(PF)activity of isolated compounds was evaluated in vitro.The results demonstrated that compounds 1–6 and 11 ameliorated transforming growth factorβ1(TGF-β1)-induced cell damage at 10μmol·L−1(P<0.01).展开更多
基金supported by the Central Government Guides the Development of Local Science and Technology(No.14104349).
文摘Twelve previously unidentified triterpenoids(1–12)were isolated from the dichloromethane extract of Alisma orientale(A.orientale).Among these compounds,1 and 2 exhibited a rare 6/6/7/5 tetracyclic ring system,and compound 3 was lanostane,isolated from A.orientale for the first time.The structures,including relative and absolute configurations,were determined through spectroscopic methods,electronic circular dichroism(ECD),Mo2(OAc)4-induced ECD,and single-crystal X-ray diffraction.The anti-pulmonary fibrosis(PF)activity of isolated compounds was evaluated in vitro.The results demonstrated that compounds 1–6 and 11 ameliorated transforming growth factorβ1(TGF-β1)-induced cell damage at 10μmol·L−1(P<0.01).
