Angiogenesis is a vital process in the event of various healthy and diseased conditions especially in the tumor metastatic pathway,and it is one of the key hallmarks of cancer cells^(1,2),therefore,angiogenesis inhibi...Angiogenesis is a vital process in the event of various healthy and diseased conditions especially in the tumor metastatic pathway,and it is one of the key hallmarks of cancer cells^(1,2),therefore,angiogenesis inhibitors are potential anti-cancer agents.However,silenced angiogenesis on the other hand could result in stroke,heart attack,and other cardiovascular diseases^(3).Yet,the precise manipulation of contradictory pro-angiogenic and anti-angiogenic signaling remains extremely challenging in both molecular biology and therapeutics.In the recent issue of J Am Chem Soc.展开更多
文摘Angiogenesis is a vital process in the event of various healthy and diseased conditions especially in the tumor metastatic pathway,and it is one of the key hallmarks of cancer cells^(1,2),therefore,angiogenesis inhibitors are potential anti-cancer agents.However,silenced angiogenesis on the other hand could result in stroke,heart attack,and other cardiovascular diseases^(3).Yet,the precise manipulation of contradictory pro-angiogenic and anti-angiogenic signaling remains extremely challenging in both molecular biology and therapeutics.In the recent issue of J Am Chem Soc.
