The threat of bacterial growth on the skin under the prosthetic liners or sleeves is an important problem,which can cause various serious diseases up to the repeated amputation.One of the promising ways to solve this ...The threat of bacterial growth on the skin under the prosthetic liners or sleeves is an important problem,which can cause various serious diseases up to the repeated amputation.One of the promising ways to solve this problem is to use antibacterial materials as a liner/sleeve material.Among others composite based on the silicone polymer with silver particles additive is may be a simple and effective solution,since the silicone is the main material for the prosthetic liners and sleeves and silver demonstrates pronounced antibacterial effect.However,the questions related to the optimal concentration of silver in silicone that results in maximum antibacterial efficiency without harming human skin are still open.In the present work,synthesis of metallic silver powder from a mixture of micro-and nanoparticles was performed and composite samples based on silicone polymer with different silver concentrations were fabricated.The antibacterial properties of fabricated samples were studied using the microdilution method against gram-positive spore-forming bacteria Bacillus subtilis.The cytotoxic effect of the tested samples was evaluated on healthy human fibroblast cell(NAF1nor).Moreover,the effect of adding silver micro-and nanoparticles to silicone on its extensibility and hardness was studied.The results showed that the addition of silver has a noticeable effect on the antibacterial properties of silicone polymer reaching more than 50%.Furthermore,all tested silicone-silver composites were shown to be non-toxic.The presence of silver does not significantly affect the relative elongation of the samples.However,hardness increases with higher silver concentrations.In the final phase,prototypes of the silver-filled silicone prosthetic sleeve were fabricated for utilisation by the patient at the prosthetic-orthopaedic clinic.The testing of the prototype was successfully completed by the patient,thereby demonstrating practical functionality and suitability for clinical use.展开更多
The absence of tactile perception limits the dexterity of a prosthetic hand and its acceptance by amputees.Recreating the sensing properties of the skin using a flexible tactile sensor could have profound implications...The absence of tactile perception limits the dexterity of a prosthetic hand and its acceptance by amputees.Recreating the sensing properties of the skin using a flexible tactile sensor could have profound implications for prosthetics,whereas existing tactile sensors often have limited functionality with cross-interference.In this study,we propose a machine-learning-assisted multifunctional tactile sensor for smart prosthetics,providing a human-like tactile sensing approach for amputations.This flexible sensor is based on a poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)-melamine sponge,which enables the detection of force and temperature with low cross-coupling owing to two separate sensing mechanisms:the open-circuit voltage of the sensor as a force-insensitive intrinsic variable to measure the absolute temperature and the resistance as a temperature-insensitive extrinsic variable to measure force.Furthermore,by analyzing the unsteady heat conduction and characterizing it using real-time thermal imaging,we demonstrated that the process of open-circuit voltage variation resulting from the unsteady heat conduction is closely correlated with the heatconducting capabilities of materials,which can be utilized to discriminate between substances.Assisted by the decision tree algorithm,the device is endowed with thermal conductivity sensing ability,which allows it to identify 10 types of substances with an accuracy of 94.7%.Furthermore,an individual wearing an advanced myoelectric prosthesis equipped with the above sensor can sense pressure,temperature,and recognize different materials.We demonstrated that our multifunctional tactile sensor provides a new strategy to help amputees feel force,temperature and identify the material of objects without the aid of vision.展开更多
Digit amputations are the most common amputation worldwide.This manuscript describes the impairments imposed by digit loss and the potential benefits of digit prosthetics.This review of the literature is designed to p...Digit amputations are the most common amputation worldwide.This manuscript describes the impairments imposed by digit loss and the potential benefits of digit prosthetics.This review of the literature is designed to provide a reference for healthcare workers and patients for identifying and selecting prosthetic options for digit amputees.展开更多
ECharles Osterberg。Dr.Osterberg is a board-certified urologist with fellowship training in male genitourinary reconstruction.He moved to Austin(TX,USA)in 2016 to join the University of Texas-Dell Medical School as As...ECharles Osterberg。Dr.Osterberg is a board-certified urologist with fellowship training in male genitourinary reconstruction.He moved to Austin(TX,USA)in 2016 to join the University of Texas-Dell Medical School as Associate Professor of Surgery.Dr.Osterberg specializes in reconstructive urology,genitourinary trauma,prosthetics,and robotic surgery.After serving as the Chief of Urology at Dell-Seton Medical Center-the main teaching hospital for Dell Medical School for 7 years,Dr.Osterberg transitioned his practice to Urology Austin,an affiliate of Urology America.At his new practice,he and his team have performed hundreds of complex urologic reconstructions and urethral stricture surgeries.展开更多
BACKGROUND Valvular heart disease affects more than 100 million people worldwide and is associated with significant morbidity and mortality.The prevalence of at least moderate valvular heart disease is 2.5%across all ...BACKGROUND Valvular heart disease affects more than 100 million people worldwide and is associated with significant morbidity and mortality.The prevalence of at least moderate valvular heart disease is 2.5%across all age groups,but its prevalence increases with age.Mitral regurgitation and aortic stenosis are the most frequent types of valvular heart disease in the community and hospital context,res-pectively.Surgical valve replacement(or mitral valve repair)is the standard of care for treating heart valve disease.However,the replacement of a prosthetic heart valve can lead to complications,either in the peri-procedural phase or in the long-term follow-up period.CASE SUMMARY We present a case of a 71-year-old female patient with a history of mitral valve replacement and warfarin anti-coagulation therapy.She was admitted to the intensive care unit due to spontaneously reperfused ischemic stroke of probable cardioembolic etiology.A dysfunctional mitral prosthesis was identified due to malfunction of one of the fixed discs.Furthermore,a possible microthrombotic lesion was suspected.Therefore,systemic thrombolysis was performed with subsequent normalization of mitral disc opening and closing.CONCLUSION This case underscores the critical importance of a multidisciplinary approach for timely decision-making in critically ill patients with prosthetic valve complications.展开更多
The prosthesis is an artificial device that can replace an organ of a human body member to restore a compromised function. It is necessary following the removal of a human organ, which can occur as a result of an illn...The prosthesis is an artificial device that can replace an organ of a human body member to restore a compromised function. It is necessary following the removal of a human organ, which can occur as a result of an illness, trauma or congenital malformation. The trans-tibia prosthesis, in particular, allows the amputee patient to recover the impaired function and regain autonomy, while facilitating their daily social integration. The trans-tibia prosthesis consists of a socket, a sleeve, connecting elements and a prosthetic foot. Each of these components plays a very important role. Among these components, the prosthetic foot usually called “SACH foot” is very often replaced due to cracking and therefore has a fairly short lifespan. At the Center for Equipment and Rehabilitation of Kabalaye (CERK), the SACH foot made using polyurethane and wood is imported and is given to patients with reduced mobility. The aim of this article is twofold, on the one hand, to make a social and pathological study of trans-tibia amputees in relation to the use of the SACH foot prosthesis, on the other hand, to compare this foot with a new prosthetic foot proposed and which is manufactured using extruded polystyrene. The result of prosthetic tests carried out on twenty-four amputees showed that the foot manufactured using extruded polystyrene is better in terms of resistance, bulk and adaptability to active amputees.展开更多
Pediatric heart valve replacement(PHVR)remains a challenging procedure due to the uniqueanatomical and physiological characteristics of children,including growth and development,as well asthe long-term need for durabl...Pediatric heart valve replacement(PHVR)remains a challenging procedure due to the uniqueanatomical and physiological characteristics of children,including growth and development,as well asthe long-term need for durable valve function.This review provides an overview of both surgical andtranscatheter options for aortic,mitral,pulmonary,and tricuspid valve replacements in pediatric patients,highlighting the indications,outcomes,and advancements in technology and technique.Surgical valvereplacement traditionally involves the implantation of biological or mechanical prosthetic valves,withbiologicalvalves beingpreferred in children to reduce the need for lifelong anticoagulation therapy.However,the limitation ofbiological prostheses,nanely their inability to grow with the child,necessitates the frequentneed for reoperations.Recent innovations in valve engineering,such as the development of tissue engineeredand expandable valves,aim to address these issues.Transcatheter valve replacement(TVR)has emergedas a promising alternative,particularly for patients with complex anatomy or those who are high-risk fortraditional surgery.While the use of transcatheter devices in children remains limited due to the smallervascular size and limited long-termn data,several studies have demonstrated the feasibility and safety ofthe procedure in certain patient populations.Despite these advancements,challenges related to valvesize,durability,and the need for individualized treatment planning persist.The future of pediatric heartvalve replacemnent will likely involve a multidisciplinary approach combining surgical,transcatheter,andregenerative medicine strategies,aimed at optimizing outcomes,reducing the need for reinterventions,andimproving long-term quality of life for pediatric patients with valvularheart disease.This article discussesall options availab le for patients with valvular dysfunction,making it easy for parents/patients to go to as areference source of information.展开更多
The stiffness information of the grasped object at the initial contact stage can be effectively used to adjust the grasping force of the prosthetic hand,thereby preventing damage to the object.However,the object’s de...The stiffness information of the grasped object at the initial contact stage can be effectively used to adjust the grasping force of the prosthetic hand,thereby preventing damage to the object.However,the object’s deformation and contact force are often minimal during the initial stage and not easily obtained directly.Additionally,stiffness estimation methods for prosthetic hands often require contact sensors,which can easily lead to poor contact issues.To address the above issues,this paper proposes the model-based stiffness estimation of grasped objects for underactuated prosthetic hands without force sensors.First,the kinematic model is linearized at the contact points to achieve the estimation of the linkage angles in the underactuated prosthetic hand.Secondly,the motor parameters are estimated using the Kalman filter method,and the grasping force is obtained from the dynamic model of the underactuated prosthetic hand.Finally,the contact model of the prosthetic hand grasping an object is established,and an online stiffness estimation method based on the contact model for the grasped object is proposed using the iterative reweighted least squares method.Experimental results show that this method can estimate the stiffness of grasped objects within 250 ms without contact sensors.展开更多
AIM:To investigate the outcome of combined anterior corneal elastic sublaminectomy,conjunctival flap,and prosthetic eyepiece for ocular atrophy following foldable capsular vitreous body(FCVB)implantation in severe tra...AIM:To investigate the outcome of combined anterior corneal elastic sublaminectomy,conjunctival flap,and prosthetic eyepiece for ocular atrophy following foldable capsular vitreous body(FCVB)implantation in severe trauma.METHODS:This study conducted a retrospective analysis of 38 patients who underwent conjunctival flap coverage followed by prosthetic eyepiece fitting after developing ocular atrophy secondary to FCVB surgery.Anterior corneal elastic sublaminectomy combined with conjunctival coverage was performed on the FCVBimplanted atrophic eyes.Prosthetic lenses were fitted after complete healing of the stroma and conjunctiva and suture removal.Corneal irritation,eyeball protrusion,axial length,lid height,cosmetic satisfaction,and pain numerical rating scale scores were observed before the conjunctival flap covering and after the prosthetic eyepiece surgery.RESULTS:The ocular protrusion was 11 mm preoperatively and 14 mm postoperatively,with the difference being statistically significant(Z=-5.459,P<0.001).The ocular axis length was 20.82±0.94 mm in the experimental group and 23.57±0.33 mm in the control group,showing a statistically significant difference(t=-20.207,P<0.05).The lid height was 6 mm in the experimental group and 9 mm in the control group,a difference that was statistically significant(Z=-5.326,P<0.001).The appearance satisfaction score was 1 in the experimental group and 4 in the control group,with this difference being statistically significant(Z=-5.447,P=0.001).Regarding the pain numerical rating scale score,the ranges were 0-2 in the experimental group and 0 in the control group.No discomfort was reported after wearing the prosthetic eyepiece,and the difference was not statistically significant(Z=-1.100,P>0.05).There was no statistically significant difference between pre-and post-treatment satisfaction.CONCLUSION:A conjunctival flap covering and a prosthetic eyepiece after FCVB postoperative atrophy can reduce the number of surgeries,alleviate patients’economic burdens,satisfy patients’psychological eyeball retention requirements,and provide better cosmetic efficacies for patients desiring eyeball retention or silicone-oil dependence.展开更多
Functionally Graded Materials(FGMs)are innovative advanced quality materials in the field of composites concerning their strength,mechanical,and thermal properties.Nowadays,the modern requirement of the industry in th...Functionally Graded Materials(FGMs)are innovative advanced quality materials in the field of composites concerning their strength,mechanical,and thermal properties.Nowadays,the modern requirement of the industry in the fields of health care,aerospace,and power sectors needs the rapid evolution of new components,which allows researchers to invent new materials to satisfy the functional requirements of modern technology.Tissue engineering is one of the most concerned areas of the application of FGM in the healthcare sector,where the tailored properties of FGM play a significant role in building and growing an artificial structure that heals the damaged tissue of the body parts and meets the desired application that the part needs to perform.This paper highlights the suitability of the combination of a nano⁃structure enhanced epoxy functionally graded material,its properties,and applicability in the design of a prosthetic foot where it provides the mobility and comfort of the body part like natural tissue.The analytical study is done by designing an ANSYS model and simulating the results of equivalent stress and directional deformation.The Finite Element(FE)approach is used to optimize the output results of stress⁃strain analysis,different weight percentages of nano⁃filler are taken for performance enhancement.A comparative analysis is done with the previously established results taking carbon fiber⁃reinforced composites that offer a successful validation of the present results obtained.Furthermore,this study also provides a clear understanding of the justification of the composition considered for the effective application in the field of prosthetics field.展开更多
The preparation of specifically iodine-125 (125I)-labeled peptides of high purity and specific activity represents a key tool for the detailed characterization of their binding properties in interaction with their bin...The preparation of specifically iodine-125 (125I)-labeled peptides of high purity and specific activity represents a key tool for the detailed characterization of their binding properties in interaction with their binding partners. Early synthetic methods for the incorporation of iodine faced challenges such as harsh reaction conditions, the use of strong oxidants and low reproducibility. Herein, we review well-established radiolabeling strategies available to incorporate radionuclide into a protein of interest, and our long-term experience with a mild, simple and generally applicable technique of 125I late-stage-labeling of biomolecules using the Pierce iodination reagent for the direct solid-phase oxidation of radioactive iodide. General recommendations, tips, and details of optimized chromatographic conditions to isolate pure, specifically 125I-mono-labeled biomolecules are illustrated on a diverse series of (poly)peptides, ranging up to 7.6 kDa and 67 amino acids (aa). These series include peptides that contain at least one tyrosine or histidine residue, along with those featuring disulfide crosslinking or lipophilic derivatization. This mild and straightforward late-stage-labeling technique is easily applicable to longer and more sensitive proteins, as demonstrated in the cases of the insulin-like growth factor binding protein-3 (IGF-BP-3) (29 kDa and 264 aa) and the acid-labile subunit (ALS) (93 kDa and 578 aa).展开更多
Locomotor intent classification has become a research hotspot due to its importance to the development of assistive robotics and wearable devices.Previous work have achieved impressive performance in classifying stead...Locomotor intent classification has become a research hotspot due to its importance to the development of assistive robotics and wearable devices.Previous work have achieved impressive performance in classifying steady locomotion states.However,it remains challenging for these methods to attain high accuracy when facing transitions between steady locomotion states.Due to the similarities between the information of the transitions and their adjacent steady states.Furthermore,most of these methods rely solely on data and overlook the objective laws between physical activities,resulting in lower accuracy,particularly when encountering complex locomotion modes such as transitions.To address the existing deficiencies,we propose the locomotion rule embedding long short-term memory(LSTM)network with Attention(LREAL)for human locomotor intent classification,with a particular focus on transitions,using data from fewer sensors(two inertial measurement units and four goniometers).The LREAL network consists of two levels:One responsible for distinguishing between steady states and transitions,and the other for the accurate identification of locomotor intent.Each classifier in these levels is composed of multiple-LSTM layers and an attention mechanism.To introduce real-world motion rules and apply constraints to the network,a prior knowledge was added to the network via a rule-modulating block.The method was tested on the ENABL3S dataset,which contains continuous locomotion date for seven steady and twelve transitions states.Experimental results showed that the LREAL network could recognize locomotor intents with an average accuracy of 99.03%and 96.52%for the steady and transitions states,respectively.It is worth noting that the LREAL network accuracy for transition-state recognition improved by 0.18%compared to other state-of-the-art network,while using data from fewer sensors.展开更多
This study aimed to comprehensively investigate the essential considerations in designing adaptive clothing for women with lower limb prostheses in Saudi Arabia. Employing a qualitative methodology, the research entai...This study aimed to comprehensively investigate the essential considerations in designing adaptive clothing for women with lower limb prostheses in Saudi Arabia. Employing a qualitative methodology, the research entailed semi-structured, in-depth interviews with women utilizing lower limb prostheses and prosthetic specialists. This approach was selected to unearth pivotal design prerequisites and comprehend the specific challenges these women encounter within the realm of clothing. The utilization of selective sampling facilitated the collection of intricate and valuable insights. A Functional, Expressive, and Aesthetic (FEA) User Needs model was utilized to scrutinize participant feedback. Functional requisites encompass ease of dressing and undressing, accessibility to the prosthetic limb, comfort, mobility with the prosthesis, and appropriate fit. Additionally, participants highlighted various expressive needs, including privacy preservation, modesty, camouflaging disability appearances, maintaining alignment with non-disabled women’s fashion, and considerations about the aesthetic aspects of garments.展开更多
Gripping devices help patients carry out everyday tasks and increase their independence.However,there seems to be a lack of bionic gripping technologies that can fully adapt to any possible shape,as the use of artific...Gripping devices help patients carry out everyday tasks and increase their independence.However,there seems to be a lack of bionic gripping technologies that can fully adapt to any possible shape,as the use of artificial fingers and predetermined grip settings limits the operating space.The development of a more agile device,which is operated by a simple control paradigm,could greatly benefit users.An electrorheological(ER)fluid system should be able to adapt to the shape of an object and then hold that configuration.The aim of this study was to explore if a conceptual prototype of an ER system could hold a geometric shape when it is activated.A test rig was constructed with a moving part(set in different silicone oils)that could be displaced using a tensometer.Silica particles were dispersed in the silicone oils,and a field with a voltage of 4 kV mm?1 was generated to activate the fluid.The results show that the developed system can support an increased force when activated and hold a simple geometric position without any noticeable delay.This outcome provides an initial proof of concept for a possible new(gravity-assisted)gripping approach using smart fluids,which could be developed with materials that are biocompatible and widely available.展开更多
With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and fut...With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.展开更多
To assist an amputee in regaining his or her daily quality of life,based on analysis of the motion characteristics of the human hip,a 2-UPR/URR parallel mechanism with a passive limb was designed.The inverse kinematic...To assist an amputee in regaining his or her daily quality of life,based on analysis of the motion characteristics of the human hip,a 2-UPR/URR parallel mechanism with a passive limb was designed.The inverse kinematics of this mechanism was analyzed based on a closed-loop vector method.The constrained Jacobian matrix and kinematic Jacobian matrix of each limb were then analyzed,and a 6×6 fully Jacobian matrix was constructed.Based on this,kinematic performances were analyzed and summarized.Finally,the dynamic model of the mechanism was constructed based on the virtual work principle,and its theoretical solution was compared with the numerical results,which were obtained in a simulation environment.Results showed that the prosthetic mechanism had a larger rotating workspace and better mechanical performance,which accorded a range of motion and bearing capacity similar to that of the human hip in multiple gait modes.Moreover,the validity of the dynamic model and inverse kinematics were verified by comparing the theoretical and simulation results.Furthermore,with flexion and extension,the torque change in the hip prosthetic mechanism was similar to that of the human hip,which demonstrated the feasibility of the hip prosthetic mechanism and its good dynamic performance.展开更多
As the essential technology of human-robotics interactive wearable devices,the robotic knee prosthesis can provide above-knee amputations with functional knee compensations to realize their physical and psychological ...As the essential technology of human-robotics interactive wearable devices,the robotic knee prosthesis can provide above-knee amputations with functional knee compensations to realize their physical and psychological social regression.With the development of mechanical and mechatronic science and technology,the fully active knee prosthesis that can provide subjects with actuating torques has demonstrated a better wearing performance in slope walking and stair ascent when compared with the passive and the semi-active ones.Additionally,with intelligent human-robotics control strategies and algorithms,the wearing effect of the knee prosthesis has been greatly enhanced in terms of stance stability and swing mobility.Therefore,to help readers to obtain an overview of recent progress in robotic knee prosthesis,this paper systematically categorized knee prostheses according to their integrated functions and introduced related research in the past ten years(2010−2020)regarding(1)mechanical design,including uniaxial,four-bar,and multi-bar knee structures,(2)actuating technology,including rigid and elastic actuation,and(3)control method,including mode identification,motion prediction,and automatic control.Quantitative and qualitative analysis and comparison of robotic knee prosthesis-related techniques are conducted.The development trends are concluded as follows:(1)bionic and lightweight structures with better mechanical performance,(2)bionic elastic actuation with energy-saving effect,(3)artificial intelligence-based bionic prosthetic control.Besides,challenges and innovative insights of customized lightweight bionic knee joint structure,highly efficient compact bionic actuation,and personalized daily multi-mode gait adaptation are also discussed in-depth to facilitate the future development of the robotic knee prosthesis.展开更多
基金the Mathematical Center in Akademgorodok(No.075-15-2022-282)with the Ministry of Science and Higher Education of the Russian FederationThe X-ray photoelectron spectroscopy and X-ray diffraction studies were performed using the facilities of the shared research center“National Center of Investigation of Catalysts”at Boreskov Institute of Catalysis.
文摘The threat of bacterial growth on the skin under the prosthetic liners or sleeves is an important problem,which can cause various serious diseases up to the repeated amputation.One of the promising ways to solve this problem is to use antibacterial materials as a liner/sleeve material.Among others composite based on the silicone polymer with silver particles additive is may be a simple and effective solution,since the silicone is the main material for the prosthetic liners and sleeves and silver demonstrates pronounced antibacterial effect.However,the questions related to the optimal concentration of silver in silicone that results in maximum antibacterial efficiency without harming human skin are still open.In the present work,synthesis of metallic silver powder from a mixture of micro-and nanoparticles was performed and composite samples based on silicone polymer with different silver concentrations were fabricated.The antibacterial properties of fabricated samples were studied using the microdilution method against gram-positive spore-forming bacteria Bacillus subtilis.The cytotoxic effect of the tested samples was evaluated on healthy human fibroblast cell(NAF1nor).Moreover,the effect of adding silver micro-and nanoparticles to silicone on its extensibility and hardness was studied.The results showed that the addition of silver has a noticeable effect on the antibacterial properties of silicone polymer reaching more than 50%.Furthermore,all tested silicone-silver composites were shown to be non-toxic.The presence of silver does not significantly affect the relative elongation of the samples.However,hardness increases with higher silver concentrations.In the final phase,prototypes of the silver-filled silicone prosthetic sleeve were fabricated for utilisation by the patient at the prosthetic-orthopaedic clinic.The testing of the prototype was successfully completed by the patient,thereby demonstrating practical functionality and suitability for clinical use.
基金the funding support from the National Key R&D Program of China(2020YFB2008501)the National Science Fund for Distinguished Young Scholars of China(62125112)+4 种基金the National Natural Science Foundation of China(62071462,62071463)the Youth Promotion Association of Chinese Academy of Sciences(2020320)the Jiangxi Provincial Natural Science Foundation(20224ACB212001)the Foundation Research Project of Jiangsu Province(BK20201195)the Suzhou Key Industrial Technology Innovation Project(SYG202029).
文摘The absence of tactile perception limits the dexterity of a prosthetic hand and its acceptance by amputees.Recreating the sensing properties of the skin using a flexible tactile sensor could have profound implications for prosthetics,whereas existing tactile sensors often have limited functionality with cross-interference.In this study,we propose a machine-learning-assisted multifunctional tactile sensor for smart prosthetics,providing a human-like tactile sensing approach for amputations.This flexible sensor is based on a poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)-melamine sponge,which enables the detection of force and temperature with low cross-coupling owing to two separate sensing mechanisms:the open-circuit voltage of the sensor as a force-insensitive intrinsic variable to measure the absolute temperature and the resistance as a temperature-insensitive extrinsic variable to measure force.Furthermore,by analyzing the unsteady heat conduction and characterizing it using real-time thermal imaging,we demonstrated that the process of open-circuit voltage variation resulting from the unsteady heat conduction is closely correlated with the heatconducting capabilities of materials,which can be utilized to discriminate between substances.Assisted by the decision tree algorithm,the device is endowed with thermal conductivity sensing ability,which allows it to identify 10 types of substances with an accuracy of 94.7%.Furthermore,an individual wearing an advanced myoelectric prosthesis equipped with the above sensor can sense pressure,temperature,and recognize different materials.We demonstrated that our multifunctional tactile sensor provides a new strategy to help amputees feel force,temperature and identify the material of objects without the aid of vision.
文摘Digit amputations are the most common amputation worldwide.This manuscript describes the impairments imposed by digit loss and the potential benefits of digit prosthetics.This review of the literature is designed to provide a reference for healthcare workers and patients for identifying and selecting prosthetic options for digit amputees.
文摘ECharles Osterberg。Dr.Osterberg is a board-certified urologist with fellowship training in male genitourinary reconstruction.He moved to Austin(TX,USA)in 2016 to join the University of Texas-Dell Medical School as Associate Professor of Surgery.Dr.Osterberg specializes in reconstructive urology,genitourinary trauma,prosthetics,and robotic surgery.After serving as the Chief of Urology at Dell-Seton Medical Center-the main teaching hospital for Dell Medical School for 7 years,Dr.Osterberg transitioned his practice to Urology Austin,an affiliate of Urology America.At his new practice,he and his team have performed hundreds of complex urologic reconstructions and urethral stricture surgeries.
文摘BACKGROUND Valvular heart disease affects more than 100 million people worldwide and is associated with significant morbidity and mortality.The prevalence of at least moderate valvular heart disease is 2.5%across all age groups,but its prevalence increases with age.Mitral regurgitation and aortic stenosis are the most frequent types of valvular heart disease in the community and hospital context,res-pectively.Surgical valve replacement(or mitral valve repair)is the standard of care for treating heart valve disease.However,the replacement of a prosthetic heart valve can lead to complications,either in the peri-procedural phase or in the long-term follow-up period.CASE SUMMARY We present a case of a 71-year-old female patient with a history of mitral valve replacement and warfarin anti-coagulation therapy.She was admitted to the intensive care unit due to spontaneously reperfused ischemic stroke of probable cardioembolic etiology.A dysfunctional mitral prosthesis was identified due to malfunction of one of the fixed discs.Furthermore,a possible microthrombotic lesion was suspected.Therefore,systemic thrombolysis was performed with subsequent normalization of mitral disc opening and closing.CONCLUSION This case underscores the critical importance of a multidisciplinary approach for timely decision-making in critically ill patients with prosthetic valve complications.
文摘The prosthesis is an artificial device that can replace an organ of a human body member to restore a compromised function. It is necessary following the removal of a human organ, which can occur as a result of an illness, trauma or congenital malformation. The trans-tibia prosthesis, in particular, allows the amputee patient to recover the impaired function and regain autonomy, while facilitating their daily social integration. The trans-tibia prosthesis consists of a socket, a sleeve, connecting elements and a prosthetic foot. Each of these components plays a very important role. Among these components, the prosthetic foot usually called “SACH foot” is very often replaced due to cracking and therefore has a fairly short lifespan. At the Center for Equipment and Rehabilitation of Kabalaye (CERK), the SACH foot made using polyurethane and wood is imported and is given to patients with reduced mobility. The aim of this article is twofold, on the one hand, to make a social and pathological study of trans-tibia amputees in relation to the use of the SACH foot prosthesis, on the other hand, to compare this foot with a new prosthetic foot proposed and which is manufactured using extruded polystyrene. The result of prosthetic tests carried out on twenty-four amputees showed that the foot manufactured using extruded polystyrene is better in terms of resistance, bulk and adaptability to active amputees.
文摘Pediatric heart valve replacement(PHVR)remains a challenging procedure due to the uniqueanatomical and physiological characteristics of children,including growth and development,as well asthe long-term need for durable valve function.This review provides an overview of both surgical andtranscatheter options for aortic,mitral,pulmonary,and tricuspid valve replacements in pediatric patients,highlighting the indications,outcomes,and advancements in technology and technique.Surgical valvereplacement traditionally involves the implantation of biological or mechanical prosthetic valves,withbiologicalvalves beingpreferred in children to reduce the need for lifelong anticoagulation therapy.However,the limitation ofbiological prostheses,nanely their inability to grow with the child,necessitates the frequentneed for reoperations.Recent innovations in valve engineering,such as the development of tissue engineeredand expandable valves,aim to address these issues.Transcatheter valve replacement(TVR)has emergedas a promising alternative,particularly for patients with complex anatomy or those who are high-risk fortraditional surgery.While the use of transcatheter devices in children remains limited due to the smallervascular size and limited long-termn data,several studies have demonstrated the feasibility and safety ofthe procedure in certain patient populations.Despite these advancements,challenges related to valvesize,durability,and the need for individualized treatment planning persist.The future of pediatric heartvalve replacemnent will likely involve a multidisciplinary approach combining surgical,transcatheter,andregenerative medicine strategies,aimed at optimizing outcomes,reducing the need for reinterventions,andimproving long-term quality of life for pediatric patients with valvularheart disease.This article discussesall options availab le for patients with valvular dysfunction,making it easy for parents/patients to go to as areference source of information.
基金supported by the National Natural Science Foundation of China under Grant 52275297.
文摘The stiffness information of the grasped object at the initial contact stage can be effectively used to adjust the grasping force of the prosthetic hand,thereby preventing damage to the object.However,the object’s deformation and contact force are often minimal during the initial stage and not easily obtained directly.Additionally,stiffness estimation methods for prosthetic hands often require contact sensors,which can easily lead to poor contact issues.To address the above issues,this paper proposes the model-based stiffness estimation of grasped objects for underactuated prosthetic hands without force sensors.First,the kinematic model is linearized at the contact points to achieve the estimation of the linkage angles in the underactuated prosthetic hand.Secondly,the motor parameters are estimated using the Kalman filter method,and the grasping force is obtained from the dynamic model of the underactuated prosthetic hand.Finally,the contact model of the prosthetic hand grasping an object is established,and an online stiffness estimation method based on the contact model for the grasped object is proposed using the iterative reweighted least squares method.Experimental results show that this method can estimate the stiffness of grasped objects within 250 ms without contact sensors.
基金Supported by National Natural Science Foundation of China(No.82260210)General Project of Jiangxi Provincial Traditional Chinese Medicine Science and Technology Plan(No.2023B1368).
文摘AIM:To investigate the outcome of combined anterior corneal elastic sublaminectomy,conjunctival flap,and prosthetic eyepiece for ocular atrophy following foldable capsular vitreous body(FCVB)implantation in severe trauma.METHODS:This study conducted a retrospective analysis of 38 patients who underwent conjunctival flap coverage followed by prosthetic eyepiece fitting after developing ocular atrophy secondary to FCVB surgery.Anterior corneal elastic sublaminectomy combined with conjunctival coverage was performed on the FCVBimplanted atrophic eyes.Prosthetic lenses were fitted after complete healing of the stroma and conjunctiva and suture removal.Corneal irritation,eyeball protrusion,axial length,lid height,cosmetic satisfaction,and pain numerical rating scale scores were observed before the conjunctival flap covering and after the prosthetic eyepiece surgery.RESULTS:The ocular protrusion was 11 mm preoperatively and 14 mm postoperatively,with the difference being statistically significant(Z=-5.459,P<0.001).The ocular axis length was 20.82±0.94 mm in the experimental group and 23.57±0.33 mm in the control group,showing a statistically significant difference(t=-20.207,P<0.05).The lid height was 6 mm in the experimental group and 9 mm in the control group,a difference that was statistically significant(Z=-5.326,P<0.001).The appearance satisfaction score was 1 in the experimental group and 4 in the control group,with this difference being statistically significant(Z=-5.447,P=0.001).Regarding the pain numerical rating scale score,the ranges were 0-2 in the experimental group and 0 in the control group.No discomfort was reported after wearing the prosthetic eyepiece,and the difference was not statistically significant(Z=-1.100,P>0.05).There was no statistically significant difference between pre-and post-treatment satisfaction.CONCLUSION:A conjunctival flap covering and a prosthetic eyepiece after FCVB postoperative atrophy can reduce the number of surgeries,alleviate patients’economic burdens,satisfy patients’psychological eyeball retention requirements,and provide better cosmetic efficacies for patients desiring eyeball retention or silicone-oil dependence.
基金Sponsored by the Science and Technology Department,Government of Ddisha(Grant No.3724/ST,Bhubaneswar,dt.14.09.2022).
文摘Functionally Graded Materials(FGMs)are innovative advanced quality materials in the field of composites concerning their strength,mechanical,and thermal properties.Nowadays,the modern requirement of the industry in the fields of health care,aerospace,and power sectors needs the rapid evolution of new components,which allows researchers to invent new materials to satisfy the functional requirements of modern technology.Tissue engineering is one of the most concerned areas of the application of FGM in the healthcare sector,where the tailored properties of FGM play a significant role in building and growing an artificial structure that heals the damaged tissue of the body parts and meets the desired application that the part needs to perform.This paper highlights the suitability of the combination of a nano⁃structure enhanced epoxy functionally graded material,its properties,and applicability in the design of a prosthetic foot where it provides the mobility and comfort of the body part like natural tissue.The analytical study is done by designing an ANSYS model and simulating the results of equivalent stress and directional deformation.The Finite Element(FE)approach is used to optimize the output results of stress⁃strain analysis,different weight percentages of nano⁃filler are taken for performance enhancement.A comparative analysis is done with the previously established results taking carbon fiber⁃reinforced composites that offer a successful validation of the present results obtained.Furthermore,this study also provides a clear understanding of the justification of the composition considered for the effective application in the field of prosthetics field.
基金Institutional support was provided by the project of the Czech Academy of Sciences,Czech Republic(to the Institute of Organic Chemistry and Biochemistry)(Project No.:RVO 61388963)This work was supported by the project National Institute for Research of Metabolic and Cardiovascular Diseases(Programme EXCELES)funded by the European Union's Next Generation EU(Project No.:LX22NPO5104)the Czech Science Foundation,Czech Republic(Grant No.:23-05805S).
文摘The preparation of specifically iodine-125 (125I)-labeled peptides of high purity and specific activity represents a key tool for the detailed characterization of their binding properties in interaction with their binding partners. Early synthetic methods for the incorporation of iodine faced challenges such as harsh reaction conditions, the use of strong oxidants and low reproducibility. Herein, we review well-established radiolabeling strategies available to incorporate radionuclide into a protein of interest, and our long-term experience with a mild, simple and generally applicable technique of 125I late-stage-labeling of biomolecules using the Pierce iodination reagent for the direct solid-phase oxidation of radioactive iodide. General recommendations, tips, and details of optimized chromatographic conditions to isolate pure, specifically 125I-mono-labeled biomolecules are illustrated on a diverse series of (poly)peptides, ranging up to 7.6 kDa and 67 amino acids (aa). These series include peptides that contain at least one tyrosine or histidine residue, along with those featuring disulfide crosslinking or lipophilic derivatization. This mild and straightforward late-stage-labeling technique is easily applicable to longer and more sensitive proteins, as demonstrated in the cases of the insulin-like growth factor binding protein-3 (IGF-BP-3) (29 kDa and 264 aa) and the acid-labile subunit (ALS) (93 kDa and 578 aa).
基金funded by the National Natural Science Foundation of China(Nos.62072212,62302218)the Development Project of Jilin Province of China(Nos.20220508125RC,20230201065GX,20240101364JC)+1 种基金National Key R&D Program(No.2018YFC2001302)the Jilin Provincial Key Laboratory of Big Data Intelligent Cognition(No.20210504003GH).
文摘Locomotor intent classification has become a research hotspot due to its importance to the development of assistive robotics and wearable devices.Previous work have achieved impressive performance in classifying steady locomotion states.However,it remains challenging for these methods to attain high accuracy when facing transitions between steady locomotion states.Due to the similarities between the information of the transitions and their adjacent steady states.Furthermore,most of these methods rely solely on data and overlook the objective laws between physical activities,resulting in lower accuracy,particularly when encountering complex locomotion modes such as transitions.To address the existing deficiencies,we propose the locomotion rule embedding long short-term memory(LSTM)network with Attention(LREAL)for human locomotor intent classification,with a particular focus on transitions,using data from fewer sensors(two inertial measurement units and four goniometers).The LREAL network consists of two levels:One responsible for distinguishing between steady states and transitions,and the other for the accurate identification of locomotor intent.Each classifier in these levels is composed of multiple-LSTM layers and an attention mechanism.To introduce real-world motion rules and apply constraints to the network,a prior knowledge was added to the network via a rule-modulating block.The method was tested on the ENABL3S dataset,which contains continuous locomotion date for seven steady and twelve transitions states.Experimental results showed that the LREAL network could recognize locomotor intents with an average accuracy of 99.03%and 96.52%for the steady and transitions states,respectively.It is worth noting that the LREAL network accuracy for transition-state recognition improved by 0.18%compared to other state-of-the-art network,while using data from fewer sensors.
文摘This study aimed to comprehensively investigate the essential considerations in designing adaptive clothing for women with lower limb prostheses in Saudi Arabia. Employing a qualitative methodology, the research entailed semi-structured, in-depth interviews with women utilizing lower limb prostheses and prosthetic specialists. This approach was selected to unearth pivotal design prerequisites and comprehend the specific challenges these women encounter within the realm of clothing. The utilization of selective sampling facilitated the collection of intricate and valuable insights. A Functional, Expressive, and Aesthetic (FEA) User Needs model was utilized to scrutinize participant feedback. Functional requisites encompass ease of dressing and undressing, accessibility to the prosthetic limb, comfort, mobility with the prosthesis, and appropriate fit. Additionally, participants highlighted various expressive needs, including privacy preservation, modesty, camouflaging disability appearances, maintaining alignment with non-disabled women’s fashion, and considerations about the aesthetic aspects of garments.
文摘Gripping devices help patients carry out everyday tasks and increase their independence.However,there seems to be a lack of bionic gripping technologies that can fully adapt to any possible shape,as the use of artificial fingers and predetermined grip settings limits the operating space.The development of a more agile device,which is operated by a simple control paradigm,could greatly benefit users.An electrorheological(ER)fluid system should be able to adapt to the shape of an object and then hold that configuration.The aim of this study was to explore if a conceptual prototype of an ER system could hold a geometric shape when it is activated.A test rig was constructed with a moving part(set in different silicone oils)that could be displaced using a tensometer.Silica particles were dispersed in the silicone oils,and a field with a voltage of 4 kV mm?1 was generated to activate the fluid.The results show that the developed system can support an increased force when activated and hold a simple geometric position without any noticeable delay.This outcome provides an initial proof of concept for a possible new(gravity-assisted)gripping approach using smart fluids,which could be developed with materials that are biocompatible and widely available.
文摘With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.
基金Supported by Beijing Natural Science Foundation(Grant No.L172021)National Natural Science Foundation of China(Grant No.51875033).
文摘To assist an amputee in regaining his or her daily quality of life,based on analysis of the motion characteristics of the human hip,a 2-UPR/URR parallel mechanism with a passive limb was designed.The inverse kinematics of this mechanism was analyzed based on a closed-loop vector method.The constrained Jacobian matrix and kinematic Jacobian matrix of each limb were then analyzed,and a 6×6 fully Jacobian matrix was constructed.Based on this,kinematic performances were analyzed and summarized.Finally,the dynamic model of the mechanism was constructed based on the virtual work principle,and its theoretical solution was compared with the numerical results,which were obtained in a simulation environment.Results showed that the prosthetic mechanism had a larger rotating workspace and better mechanical performance,which accorded a range of motion and bearing capacity similar to that of the human hip in multiple gait modes.Moreover,the validity of the dynamic model and inverse kinematics were verified by comparing the theoretical and simulation results.Furthermore,with flexion and extension,the torque change in the hip prosthetic mechanism was similar to that of the human hip,which demonstrated the feasibility of the hip prosthetic mechanism and its good dynamic performance.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.62003060,51975070 and 62033001)the National Key Research and Development Program of China under Grant 2020YFB1313000.
文摘As the essential technology of human-robotics interactive wearable devices,the robotic knee prosthesis can provide above-knee amputations with functional knee compensations to realize their physical and psychological social regression.With the development of mechanical and mechatronic science and technology,the fully active knee prosthesis that can provide subjects with actuating torques has demonstrated a better wearing performance in slope walking and stair ascent when compared with the passive and the semi-active ones.Additionally,with intelligent human-robotics control strategies and algorithms,the wearing effect of the knee prosthesis has been greatly enhanced in terms of stance stability and swing mobility.Therefore,to help readers to obtain an overview of recent progress in robotic knee prosthesis,this paper systematically categorized knee prostheses according to their integrated functions and introduced related research in the past ten years(2010−2020)regarding(1)mechanical design,including uniaxial,four-bar,and multi-bar knee structures,(2)actuating technology,including rigid and elastic actuation,and(3)control method,including mode identification,motion prediction,and automatic control.Quantitative and qualitative analysis and comparison of robotic knee prosthesis-related techniques are conducted.The development trends are concluded as follows:(1)bionic and lightweight structures with better mechanical performance,(2)bionic elastic actuation with energy-saving effect,(3)artificial intelligence-based bionic prosthetic control.Besides,challenges and innovative insights of customized lightweight bionic knee joint structure,highly efficient compact bionic actuation,and personalized daily multi-mode gait adaptation are also discussed in-depth to facilitate the future development of the robotic knee prosthesis.
