Background:Inflatable Penile Prosthesis(IPP)is the treatment for erectile dysfunction(ED)refractory to pharmacological therapies.Long-term data on factors associated with prosthesis survival remain unclear.This study ...Background:Inflatable Penile Prosthesis(IPP)is the treatment for erectile dysfunction(ED)refractory to pharmacological therapies.Long-term data on factors associated with prosthesis survival remain unclear.This study aimed to analyze the long-term survival of penile prostheses and identify risk factors associated with survival without reintervention.Methods:This is a retrospective,single-center study of patients who underwent IPP implantation between January 2014 and December 2022.Preoperative data related to the patient and the etiology of ED,as well as perioperative data,were collected.The primary outcome was survival without reintervention,defined as prosthesis revision or explantation due to mechanical dysfunction or infection.We conducted survival analyses without reintervention and searched for risk factors using a multivariate Cox model.Results:In total,33 out of 137 patients underwent reintervention(24.1%),including 24(17.5%)prosthesis revisions and 9(6.6%)had explantations.Median follow-up was 39 months with an interquartile range(IQR)of 9.00 to 62.00.Median survival without reintervention was 7 years.In univariate analysis,downsizing(p=0.046)was associated with reintervention.Smoking(p=0.003)and age(p=0.034)were associated with prosthesis explantation.The number of implantations(p=0.009)was associated with prosthesis revision.Multivariate analysis by the Cox model did not identify any independent predictive factors for reintervention.Conclusion:Smoking may play a role in infection post-IPP implantation.Primary implantations seem to be associated with better survival.Adjusting cylinder size,known as downsizing,is likely to be a proxy for the complexity of the procedure and thus linked to earlier reintervention.展开更多
Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,...Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,and knee,caused by echinococ cosis.Artificial intelligence(AI)was used to develop a targeted surgical plan and to design a personalized prosthesis.Finite element analysis(FEA)was used to optimize the mechanical effectiveness of a customized integrated replacement prosthesis and to model stress distribution in the surrounding bone.Three-dimensional(3 D)printing was used to fabricate a customized prosthesis.With the assistance of AI,FEA,and 3 D printing technology,a personalized surgical plan and customized prosthesis were successfully constructed based on the patient’s disease.This approach achieved a successful therapeutic effect,demonstrating that AI-assisted personalized medicine holds great promise for the future.展开更多
Maxillary bone loss impairs essential functions (chewing, swallowing, speech) and gives patients a very unaesthetic appearance due to the removal of facial support tissues, leading to serious psychological consequence...Maxillary bone loss impairs essential functions (chewing, swallowing, speech) and gives patients a very unaesthetic appearance due to the removal of facial support tissues, leading to serious psychological consequences. Treatment is multidisciplinary and requires a resective surgery if the cause is tumor-related, or an additive surgery if the cause is traumatic. This article aims to show the role of making a prosthesis to restore function (chewing, swallowing, speech) and aesthetics following maxillary bone loss. We will eighter present a clinical case involving a right maxillary tumor that was surgically resected followed by radiotherapy, and subsequently rehabilitated with a maxillofacial prosthesis in the consultation and dental treatment center of the university hospital center of Casablanca.展开更多
Human vision,confined to visible wavelengths,represents a mere fraction of the electromagnetic spectrum exploited by other species.Pit vipers detect infrared radiation through specialized pit organs,integrating therma...Human vision,confined to visible wavelengths,represents a mere fraction of the electromagnetic spectrum exploited by other species.Pit vipers detect infrared radiation through specialized pit organs,integrating thermal and visual data to navigate darkness[1].Conventional retinal prosthetics,limited to visible light and requiring external power or injectable nanomaterials,fail to address this sensory deficit[2–5].展开更多
This paper presents an innovative design of a Bionic Powered Ankle Prosthesis(BPAP)utilizing a muscle recruitment mechanism-inspired clutch,aimed at achieving biomimetic simulation of ankle muscle function.To address ...This paper presents an innovative design of a Bionic Powered Ankle Prosthesis(BPAP)utilizing a muscle recruitment mechanism-inspired clutch,aimed at achieving biomimetic simulation of ankle muscle function.To address the varying stiffness requirements of the prosthesis across different gaits,the clutch dynamically switch between different rope bundle combinations.The mechanical characteristics during the load traction process of the selected flexible ropes are also studied.A mathematical model of the series elastic drive system is established.The optimization is carried out with the minimum peak power required by the motor as the optimization goal.The experimental results show that by applying a clutch with human muscle recruitment mechanism,the proposed prosthesis can achieve better energy efficiency at different speeds.展开更多
A pulse frequency modulation（PFM） circuit for retinal prosthesis,which generates electrical pulses with frequency proportional to the intensity of incident light, is presented. The fundamental characteristic of the ...A pulse frequency modulation（PFM） circuit for retinal prosthesis,which generates electrical pulses with frequency proportional to the intensity of incident light, is presented. The fundamental characteristic of the circuit is described and analyzed. The circuit is realized in 0.6μm CMOS process,and the simulation results testify to the possibility of sub-retinal implantation.展开更多
The CAD model of molar prosthesis is usually stored in standard templete library （STIr） format. A new topological structure is given based on STL format and the vertex-based entity offset algorithm is presented to r...The CAD model of molar prosthesis is usually stored in standard templete library （STIr） format. A new topological structure is given based on STL format and the vertex-based entity offset algorithm is presented to realize the rapid generation of roughing/finishing tool path for molar prosthesis. Simulation results show that the proposed algorithm prossesses characteristics of excellent stabilization, fast calculation speed and high machining accuracy.展开更多
文摘Background:Inflatable Penile Prosthesis(IPP)is the treatment for erectile dysfunction(ED)refractory to pharmacological therapies.Long-term data on factors associated with prosthesis survival remain unclear.This study aimed to analyze the long-term survival of penile prostheses and identify risk factors associated with survival without reintervention.Methods:This is a retrospective,single-center study of patients who underwent IPP implantation between January 2014 and December 2022.Preoperative data related to the patient and the etiology of ED,as well as perioperative data,were collected.The primary outcome was survival without reintervention,defined as prosthesis revision or explantation due to mechanical dysfunction or infection.We conducted survival analyses without reintervention and searched for risk factors using a multivariate Cox model.Results:In total,33 out of 137 patients underwent reintervention(24.1%),including 24(17.5%)prosthesis revisions and 9(6.6%)had explantations.Median follow-up was 39 months with an interquartile range(IQR)of 9.00 to 62.00.Median survival without reintervention was 7 years.In univariate analysis,downsizing(p=0.046)was associated with reintervention.Smoking(p=0.003)and age(p=0.034)were associated with prosthesis explantation.The number of implantations(p=0.009)was associated with prosthesis revision.Multivariate analysis by the Cox model did not identify any independent predictive factors for reintervention.Conclusion:Smoking may play a role in infection post-IPP implantation.Primary implantations seem to be associated with better survival.Adjusting cylinder size,known as downsizing,is likely to be a proxy for the complexity of the procedure and thus linked to earlier reintervention.
基金partially supported by the National Natural Science Foundation of China(Nos.32471474 and 82102574)the Precision Medicine Project of People’s Hospital of Xinjiang Uygur Autonomous Region(No.20220305)+4 种基金Chengdu Advanced Metal Materials Industry Technology Research Institute Co.,Ltd.Support Project(No.24H0802)Sichuan Science and Technology Program(Nos.2025YFHZ0086,2023YFS0053,2024YFHZ0125,and 2025ZNSFSC0381)Project of Tianfu Jincheng Laboratory(No.2025ZH009)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515220102)Xinjiang Autonomous Region Science and Technology Support Project Plan(Directive)Project(No.2024E02049)。
文摘Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,and knee,caused by echinococ cosis.Artificial intelligence(AI)was used to develop a targeted surgical plan and to design a personalized prosthesis.Finite element analysis(FEA)was used to optimize the mechanical effectiveness of a customized integrated replacement prosthesis and to model stress distribution in the surrounding bone.Three-dimensional(3 D)printing was used to fabricate a customized prosthesis.With the assistance of AI,FEA,and 3 D printing technology,a personalized surgical plan and customized prosthesis were successfully constructed based on the patient’s disease.This approach achieved a successful therapeutic effect,demonstrating that AI-assisted personalized medicine holds great promise for the future.
文摘Maxillary bone loss impairs essential functions (chewing, swallowing, speech) and gives patients a very unaesthetic appearance due to the removal of facial support tissues, leading to serious psychological consequences. Treatment is multidisciplinary and requires a resective surgery if the cause is tumor-related, or an additive surgery if the cause is traumatic. This article aims to show the role of making a prosthesis to restore function (chewing, swallowing, speech) and aesthetics following maxillary bone loss. We will eighter present a clinical case involving a right maxillary tumor that was surgically resected followed by radiotherapy, and subsequently rehabilitated with a maxillofacial prosthesis in the consultation and dental treatment center of the university hospital center of Casablanca.
基金supported by the National Key Research and Development Program from Ministry of Science and Technology(No.2023YFB3208102).
文摘Human vision,confined to visible wavelengths,represents a mere fraction of the electromagnetic spectrum exploited by other species.Pit vipers detect infrared radiation through specialized pit organs,integrating thermal and visual data to navigate darkness[1].Conventional retinal prosthetics,limited to visible light and requiring external power or injectable nanomaterials,fail to address this sensory deficit[2–5].
基金supported in part by National Natural Science Foundation of China[Grant No.62203356].
文摘This paper presents an innovative design of a Bionic Powered Ankle Prosthesis(BPAP)utilizing a muscle recruitment mechanism-inspired clutch,aimed at achieving biomimetic simulation of ankle muscle function.To address the varying stiffness requirements of the prosthesis across different gaits,the clutch dynamically switch between different rope bundle combinations.The mechanical characteristics during the load traction process of the selected flexible ropes are also studied.A mathematical model of the series elastic drive system is established.The optimization is carried out with the minimum peak power required by the motor as the optimization goal.The experimental results show that by applying a clutch with human muscle recruitment mechanism,the proposed prosthesis can achieve better energy efficiency at different speeds.
文摘A pulse frequency modulation（PFM） circuit for retinal prosthesis,which generates electrical pulses with frequency proportional to the intensity of incident light, is presented. The fundamental characteristic of the circuit is described and analyzed. The circuit is realized in 0.6μm CMOS process,and the simulation results testify to the possibility of sub-retinal implantation.
文摘The CAD model of molar prosthesis is usually stored in standard templete library （STIr） format. A new topological structure is given based on STL format and the vertex-based entity offset algorithm is presented to realize the rapid generation of roughing/finishing tool path for molar prosthesis. Simulation results show that the proposed algorithm prossesses characteristics of excellent stabilization, fast calculation speed and high machining accuracy.
