Background:The global rise in angina pectoris,a symptom of coronary artery disease,is primarily attributed to an aging population and increasing prevalence of comorbidities.This study aims to assess the efficacy and s...Background:The global rise in angina pectoris,a symptom of coronary artery disease,is primarily attributed to an aging population and increasing prevalence of comorbidities.This study aims to assess the efficacy and safety of Dazhu Hongjingtian injection(DZHJTI)as an adjunct treatment for both stable and unstable angina,thereby addressing a significant gap in current cardiac care research.Methods:This comprehensive study involves 2 parallel prospective cohorts across 28 medical centers in China,enrolling 1500 patients with stable angina and 2000 with unstable angina.Participants are randomized into 2 groups:one receiving the DZHJTI alongside standard therapy and the other receiving standard therapy alone.The study employs advanced statistical methods like Subgroup Analysis and Marginal Mean Weighting Through Stratification to analyze data accurately.Discussion:The primary outcome of this study is the reduction in the frequency of angina attacks posttreatment.Secondary outcomes include the evaluation of patient well-being through clinical measures such as nitrate dosage requirements,vital sign stability,electrocardiogram changes,and laboratory data.Patient-reported outcomes from targeted questionnaires will also be assessed to understand the impact on quality of life.The study’s results are expected to contribute significantly to the understanding of DZHJTI’s role in treating angina pectoris,potentially influencing future treatment guidelines.展开更多
BACKGROUND The incidence of postoperative nausea and vomiting(PONV)in patients undergoing laparoscopic hysterectomy is very high compared with other surgeries,even when many prophylactic measures have been taken.Howev...BACKGROUND The incidence of postoperative nausea and vomiting(PONV)in patients undergoing laparoscopic hysterectomy is very high compared with other surgeries,even when many prophylactic measures have been taken.However,the pathogenesis of PONV is multifactorial.Female sex,a history of motion sickness or PONV,nonsmokers,and perioperative opioid use are the most closely related factors.Among the multiple risk factors,suboptimal gastrointestinal(GI)perfusion may be attributed to some cases of PONV,and increased systemic vascular resistance(SVR)may lead to GI ischemia.The hypothesis of this research was that SVR is related to PONV.AIM To investigate the relationship between SVR and PONV in patients undergoing laparoscopic hysterectomy.METHODS A total of 228 patients who underwent elective laparoscopic hysterectomy were included in this prospective observational study.SVR was monitored using a noninvasive hemodynamic monitoring system.Four indices of SVR,the baseline,mean,area under the curve(AUC),and weighted AUC,were used for analysis.The incidence and severity of nausea and vomiting were evaluated while patients were awake and throughout the intervals from 0 to 2 h,2 to 6 h,and 6 to 24 h starting upon arrival at the post-anesthesia care unit.The associations between various SVR indices and PONV were investigated by logistic regression.P<0.05 was considered statistically significant.RESULTS The incidence of PONV in the study was 56.14%(128/228),and PONV tended to appear within 6 h after surgery.Five variables were significant in univariate analyses,however,only SVR mean[odds ratio(OR)=1.015,95%CI:1.005-1.109,P=0.047]and duration of surgery(OR=1.316,95%CI:1.003-2.030,P=0.012)were associated with PONV after logistic regression analysis.Furthermore,patients with high SVR mean were more likely to suffer from PONV after laparoscopic hysterectomy.On average,patients who developed PONV needed more time to tolerate diet and demonstrated poorer sleep quality on the first night after surgery.CONCLUSION In this study,PONV was a common complication after laparoscopic hysterectomy.SVR was associated with PONV,and high SVR mean was associated with a significantly increased risk of PONV.展开更多
Objective To evaluate the efficacy of homodimer neutrophil gelatinase-associated lipocalin(H-NGAL)rapid test kit in diagnosing peritoneal dialysis(PD)-associated peritonitis(PDAP).Methods It was a multicenter prospect...Objective To evaluate the efficacy of homodimer neutrophil gelatinase-associated lipocalin(H-NGAL)rapid test kit in diagnosing peritoneal dialysis(PD)-associated peritonitis(PDAP).Methods It was a multicenter prospective observational study.The PD patients from the nephrology clinics or wards at four hospitals,i.e.,the First Affiliated Hospital of Nanchang University,the Third Hospital of Hebei Medical University,Taian Central Hospital,and Weifang People's Hospital from December 27,2021,and July 18,2022 were enrolled.The patients were categorized into PDAP and non-PDAP groups based on whether PDAP occurred at the time of enrollment.PD effluent sampleswerecollected,andH-NGAL test was performed.The patients or their families used cassette type,strip-type,and pen-type H-NGAL test kits to detect H-NGAL.Healthcare professionals only used the cassette-type H-NGAL kit to detect H-NGAL.All participants completed a questionnaire regarding the instructions for use of H-NGAL kit before testing,and a summaryof patient experienceandevaluation questionnaires after testing.The sensitivity,specificity,compliance rate,and 95%confidence interval(CI)of H-NGAL rapid test kit for diagnosing PDAP were calculated using clinical diagnosis as the standard.Kappa test was used to assess the consistency between HNGAL detection results and clinical diagnoses.Results A total of 221 PD patients were enrolled,with 42 PDAP patients and 179 non-PDAP patients.The sensitivity and specificity of H-NGAL rapid test kit for diagnosing PDAP were 100%(95%CI 91.62%-100%)and 99.44%(95%CI 96.90%-99.90%),respectively,with accuracy rate of 99.55%(95%CI 97.48%-99.92%).The positive agreement rate was 97.67%(95%CI 87.94%-99.59%),and the negative agreement rate was 100%(95%CI 97.89%-100%).The consistency evaluation results showed that kappa value was 0.985(95%CI 0.956-1.000).The results obtained by patients and their families using the H-NGAL rapid test kits were consistent across all three methods(cassette,strip,and pen-type H-NGAL test kits),and the results obtained by using the H-NGAL rapid test kits were also consistent between nonhealthcare professionals and healthcare professionals.The kit instruction questionnaire and the experience and evaluation questionnaireshowed that theoverall satisfaction of patients with the H-NGAL rapid test kits was very good.Conclusion H-NGAL rapid test kit exhibits high sensitivity and specificity in diagnosing PDAP and can serve as a rapid diagnostic method for PDAP.展开更多
The Water Cherenkov Detector Array(WCDA) is a major component of the Large High Altitude Air Shower Array Observatory(LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under con...The Water Cherenkov Detector Array(WCDA) is a major component of the Large High Altitude Air Shower Array Observatory(LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under construction. WCDA is aimed at the study of TeV γ-rays. In order to evaluate the prospects of searching for TeV γ-ray sources with WCDA, we present a projection of the one-year sensitivity of WCDA to TeV γ-ray sources from TeVCat using an all-sky approach. Out of 128 TeVCat sources observable by WCDA up to a zenith angle of 45°, we estimate that 42 would be detectable in one year of observations at a median energy of 1 TeV. Most of them are Galactic sources, and the extragalactic sources are Active Galactic Nuclei(AGN).展开更多
基金the China Academy of Chinese Medical Sciences Innovation Fund(No.CI2021A00702-3)National Natural Science Foundation of China(No.82174532)2022 Qi Huang Young Scholar programme of the National Administration of Traditional Chinese Medicine(Z0841,Z0865).
文摘Background:The global rise in angina pectoris,a symptom of coronary artery disease,is primarily attributed to an aging population and increasing prevalence of comorbidities.This study aims to assess the efficacy and safety of Dazhu Hongjingtian injection(DZHJTI)as an adjunct treatment for both stable and unstable angina,thereby addressing a significant gap in current cardiac care research.Methods:This comprehensive study involves 2 parallel prospective cohorts across 28 medical centers in China,enrolling 1500 patients with stable angina and 2000 with unstable angina.Participants are randomized into 2 groups:one receiving the DZHJTI alongside standard therapy and the other receiving standard therapy alone.The study employs advanced statistical methods like Subgroup Analysis and Marginal Mean Weighting Through Stratification to analyze data accurately.Discussion:The primary outcome of this study is the reduction in the frequency of angina attacks posttreatment.Secondary outcomes include the evaluation of patient well-being through clinical measures such as nitrate dosage requirements,vital sign stability,electrocardiogram changes,and laboratory data.Patient-reported outcomes from targeted questionnaires will also be assessed to understand the impact on quality of life.The study’s results are expected to contribute significantly to the understanding of DZHJTI’s role in treating angina pectoris,potentially influencing future treatment guidelines.
文摘BACKGROUND The incidence of postoperative nausea and vomiting(PONV)in patients undergoing laparoscopic hysterectomy is very high compared with other surgeries,even when many prophylactic measures have been taken.However,the pathogenesis of PONV is multifactorial.Female sex,a history of motion sickness or PONV,nonsmokers,and perioperative opioid use are the most closely related factors.Among the multiple risk factors,suboptimal gastrointestinal(GI)perfusion may be attributed to some cases of PONV,and increased systemic vascular resistance(SVR)may lead to GI ischemia.The hypothesis of this research was that SVR is related to PONV.AIM To investigate the relationship between SVR and PONV in patients undergoing laparoscopic hysterectomy.METHODS A total of 228 patients who underwent elective laparoscopic hysterectomy were included in this prospective observational study.SVR was monitored using a noninvasive hemodynamic monitoring system.Four indices of SVR,the baseline,mean,area under the curve(AUC),and weighted AUC,were used for analysis.The incidence and severity of nausea and vomiting were evaluated while patients were awake and throughout the intervals from 0 to 2 h,2 to 6 h,and 6 to 24 h starting upon arrival at the post-anesthesia care unit.The associations between various SVR indices and PONV were investigated by logistic regression.P<0.05 was considered statistically significant.RESULTS The incidence of PONV in the study was 56.14%(128/228),and PONV tended to appear within 6 h after surgery.Five variables were significant in univariate analyses,however,only SVR mean[odds ratio(OR)=1.015,95%CI:1.005-1.109,P=0.047]and duration of surgery(OR=1.316,95%CI:1.003-2.030,P=0.012)were associated with PONV after logistic regression analysis.Furthermore,patients with high SVR mean were more likely to suffer from PONV after laparoscopic hysterectomy.On average,patients who developed PONV needed more time to tolerate diet and demonstrated poorer sleep quality on the first night after surgery.CONCLUSION In this study,PONV was a common complication after laparoscopic hysterectomy.SVR was associated with PONV,and high SVR mean was associated with a significantly increased risk of PONV.
文摘Objective To evaluate the efficacy of homodimer neutrophil gelatinase-associated lipocalin(H-NGAL)rapid test kit in diagnosing peritoneal dialysis(PD)-associated peritonitis(PDAP).Methods It was a multicenter prospective observational study.The PD patients from the nephrology clinics or wards at four hospitals,i.e.,the First Affiliated Hospital of Nanchang University,the Third Hospital of Hebei Medical University,Taian Central Hospital,and Weifang People's Hospital from December 27,2021,and July 18,2022 were enrolled.The patients were categorized into PDAP and non-PDAP groups based on whether PDAP occurred at the time of enrollment.PD effluent sampleswerecollected,andH-NGAL test was performed.The patients or their families used cassette type,strip-type,and pen-type H-NGAL test kits to detect H-NGAL.Healthcare professionals only used the cassette-type H-NGAL kit to detect H-NGAL.All participants completed a questionnaire regarding the instructions for use of H-NGAL kit before testing,and a summaryof patient experienceandevaluation questionnaires after testing.The sensitivity,specificity,compliance rate,and 95%confidence interval(CI)of H-NGAL rapid test kit for diagnosing PDAP were calculated using clinical diagnosis as the standard.Kappa test was used to assess the consistency between HNGAL detection results and clinical diagnoses.Results A total of 221 PD patients were enrolled,with 42 PDAP patients and 179 non-PDAP patients.The sensitivity and specificity of H-NGAL rapid test kit for diagnosing PDAP were 100%(95%CI 91.62%-100%)and 99.44%(95%CI 96.90%-99.90%),respectively,with accuracy rate of 99.55%(95%CI 97.48%-99.92%).The positive agreement rate was 97.67%(95%CI 87.94%-99.59%),and the negative agreement rate was 100%(95%CI 97.89%-100%).The consistency evaluation results showed that kappa value was 0.985(95%CI 0.956-1.000).The results obtained by patients and their families using the H-NGAL rapid test kits were consistent across all three methods(cassette,strip,and pen-type H-NGAL test kits),and the results obtained by using the H-NGAL rapid test kits were also consistent between nonhealthcare professionals and healthcare professionals.The kit instruction questionnaire and the experience and evaluation questionnaireshowed that theoverall satisfaction of patients with the H-NGAL rapid test kits was very good.Conclusion H-NGAL rapid test kit exhibits high sensitivity and specificity in diagnosing PDAP and can serve as a rapid diagnostic method for PDAP.
基金Supported by National Natural Science Foundation of China(11761141001,11635011,11873005)The LHAASO project is supported by the National Key R&D Program of China(2018YFA0404200),the Chinese Academy of Sciences,the Key Laboratory of Particle Astrophysics,IHEP,CAS。
文摘The Water Cherenkov Detector Array(WCDA) is a major component of the Large High Altitude Air Shower Array Observatory(LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under construction. WCDA is aimed at the study of TeV γ-rays. In order to evaluate the prospects of searching for TeV γ-ray sources with WCDA, we present a projection of the one-year sensitivity of WCDA to TeV γ-ray sources from TeVCat using an all-sky approach. Out of 128 TeVCat sources observable by WCDA up to a zenith angle of 45°, we estimate that 42 would be detectable in one year of observations at a median energy of 1 TeV. Most of them are Galactic sources, and the extragalactic sources are Active Galactic Nuclei(AGN).
