BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gas...BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gastric mucosa and provide valuable guidance for improving treatment efficacy.METHODS A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included.Among them,296 patients were followed up with endoscopic and biopsy pathology.Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.RESULTS The distribution sites of LGIN among the 357 patients were as follows:Gastric antrum(54.6%),gastric cardia(24.1%),gastric angulus(8.7%),gastric body(4.8%),gastric fundus(4.8%),and multiple sites(3.1%).Additionally,of the 357 patients with LGIN,112(31.4%)developed ulceration and 59(16.5%)experienced gastric polyps.Furthermore,231 of the 357(64.71%)patients with LGIN tested positive for Helicobacter pylori(H.pylori)infection.The H.pylori infection rates of the patients with LGIN with accompanying atrophy,intestinal metaplasia,and gastric ulcer were 51.95%,59.31%,and 28.57%,respectively.Multivariate logistic regression analysis showed that age≥60 years[odds ratio(OR)=3.063,95%confidence interval(CI):1.351-6.945,P=0.007],H.pylori infection(OR=3.560,95%CI:1.158-10.949,P=0.027),multiple locations(OR=10.136,95%CI:2.045-50.237,P=0.005),lesion size≥2 cm(OR=3.921,95%CI:1.664-9.237,P=0.002),and gastric ulcer(OR=2.730,95%CI:1.197-6.223,P=0.017)were predictive factors for LGIN progression.CONCLUSION LGIN progression is closely related to age,H.pylori positivity,multiple locations,lesion size≥2 cm,and gastric ulcer.Thus,actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression.展开更多
Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institut...Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.展开更多
Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affecte...Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affected by many factors, including fracture type, prosthesis stability, patient age and comorbidities, and individualized treatment strategy is needed. In recent years, the internal fixation technology and prosthetic revision technology have made significant progress in surgical treatment, such as locking steel plate, titanium cable and bridge combined internal fixation system and other new technologies have effectively improved the treatment effect. In addition, the application of new materials and 3D printing technology, as well as the optimization of multidisciplinary cooperation mode, also provide new ideas for the treatment of complex fractures. However, there are still some problems such as inaccurate diagnosis, difficult choice of treatment options and high incidence of postoperative complications. In the future, technological innovation, the introduction of artificial intelligence and big data, and the further development of personalized treatment will bring more possibilities to improve the prognosis and quality of life of patients. This study summarizes the relevant research results and prospects the future development direction, providing references for clinical practice and subsequent research.展开更多
BACKGROUND Stoma creation is a common procedure in colorectal cancer surgery,however,stoma-related complications remain a significant concern.AIM To investigate the incidence,types,and risk factors of stoma-related co...BACKGROUND Stoma creation is a common procedure in colorectal cancer surgery,however,stoma-related complications remain a significant concern.AIM To investigate the incidence,types,and risk factors of stoma-related complications in colorectal cancer patients who underwent stoma creation.METHODS Patients with stoma was prospectively recorded in the established stoma system.Data was collected from this stoma management system from November 2021 through May 2024.The rates of stoma-related complications were assessed,and potential risk factors were analyzed using univariate and multivariate logistic regression models.RESULTS A total of 734 patients were included in the analysis.The results showed that 12.3%of patients experienced stoma-related complications,with mucocutaneous separation,edema,and skin excoriation being the most common complications.The majority(90%)of complications were classified as grade 2 according to the Clavien-Dindo classification.Surgical factors,such as blood loss volume greater than 500 mL and open surgery,were significantly associated with stoma complications.Additionally,stoma features like location,shape,color,height,and edema were important factors in the association with complications.Body mass index over 30 kg/m²was also found to be a significant risk factor.CONCLUSION These findings highlight the need for a holistic approach to preventing and managing stoma complications,considering both patient-related and surgical factors.展开更多
Thefield of energy storage devices is primarily dominated by lithium-ion batteries(LIBs)due to their mature manufacturing processes and stable performance.However,immature lithium recovery technology cannot stop the co...Thefield of energy storage devices is primarily dominated by lithium-ion batteries(LIBs)due to their mature manufacturing processes and stable performance.However,immature lithium recovery technology cannot stop the continuous increase in the cost of LIBs.Along with the rapid development of electric transportation,it has become inevitable to trigger a new round of competition in alternative energy storage systems.Some monovalent rechargeable metal ion batteries(sodium ion batteries(SIBs)and potassium ion batteries(PIBs),etc.)and multi-valent rechargeable metal-ion batteries(magnesium ion batteries(MIBs),calcium ion batteries(CIBs),zinc ion batteries(ZIBs),and aluminum ion batteries(AIBs),etc.)are potential candidates,which can replace LIBs in some of the scenarios to alleviate the pressure on supply.The cathode material plays a crucial role in determining the battery capacity.Transition metal compounds dominated by layered transition metal oxides as key cathode materials for secondary batteries play an important role in the advancement of various battery energy storage systems.In summary,this manuscript aims to review and summarize the research progress on transition metal compounds used as cathodes in different metal ion batteries,with the aim of providing valuable guidance for the exploration and design of high-performance integrated battery systems.展开更多
Hydrogen energy has long been considered an ideal green energy,and in particular,developed with great enthusiasm in recent years[1].To utilize hydrogen energy,efficient hydrogen storage(H-storage)and transportation ar...Hydrogen energy has long been considered an ideal green energy,and in particular,developed with great enthusiasm in recent years[1].To utilize hydrogen energy,efficient hydrogen storage(H-storage)and transportation are necessary.Although great progress has been achieved in H-storage by using high-pressure cylinder up to 70 MPa.展开更多
The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helpi...The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helping in building country’s brand value,image and identity.Eritrea has huge tourism potential owing to its natural,historical and cultural endowments.However,the tourism industry in Eritrea is only in its nascent stage.This study,therefore,try to identify and examine the major challenges of sustainable tourism development and its prospects.Primary data were collected from interview with different Ministry of Tourism authorities,travel agencies and tour operators’managers and owners.Secondary data were retrieved from annual reports of international tourism organizations,Ministry of Tourism,the State of Eritrea and other documented sources including magazines and relevant research and papers.The research concludes that Eritrea has great potential for the development of tourism.However,the tourism growth is blocked by specific factors such as poor image,inadequate tourism infrastructural and technological facilities,absence of coordination among tourism stakeholders and lack of skilled man power.This study will assist policymakers to understand the present challenges of the tourism industry and provide necessary recommendations to adopt appropriate strategies and mechanisms.展开更多
Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospe...Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospective study was conducted at four sites in rural China between 2013 and 2023.Multivariate Cox proportional hazards models and restricted cubic spline analyses were used to assess the association between BMI and mortality.Stratified analyses were performed based on the individual characteristics of the participants.Results Overall,19,107 participants with a sum of 163,095 person-years were included and 1,910 participants died.The underweight(<18.5 kg/m^(2))presented an increase in all-cause mortality(adjusted hazards ratio[aHR]=2.00,95%confidence interval[CI]:1.66–2.41),while overweight(≥24.0 to<28.0 kg/m^(2))and obesity(≥28.0 kg/m^(2))presented a decrease with an aHR of 0.61(95%CI:0.52–0.73)and 0.51(95%CI:0.37–0.70),respectively.Overweight(aHR=0.76,95%CI:0.67–0.86)and mild obesity(aHR=0.72,95%CI:0.59–0.87)had a positive impact on mortality in people older than 60 years.All-2 cause mortality decreased rapidly until reaching a BMI of 25.7 kg/m(aHR=0.95,95%CI:0.92–0.98)and increased slightly above that value,indicating a U-shaped association.The beneficial impact of being overweight on mortality was robust in most subgroups and sensitivity analyses.Conclusion This study provides additional evidence that overweight and mild obesity may be inversely related to the risk of death in individuals older than 60 years.Therefore,it is essential to consider age differences when formulating health and weight management strategies.展开更多
Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primaril...Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primarily conducted by European scientists and curators,establishing the foundation for tick taxonomy in the region.Pioneering works by George Henry Falknier Nuttall and Cecil Warburton introduced several new tick species,including Haemaphysalis(H.)calva,H.mjoebergi,H.vidua and H.wellingtoni[1].However,some records from this period are now considered doubtful,for instance Amblyomma(A.)breviscutatum,A.clypeolatum and A.integrum.The 1929 description of Ornithodoros batuensis by Stanley Hirst[2]marked the first documentation of a soft tick species in Malaysia,setting the stage for subsequent research endeavours.The Golden Age of tick studies(early 1950s-late 1980s)in Malaysia saw a surge in tick research activities.展开更多
ChatGPT technology based on large language models(LLM)shows great potential in improving the quality of medical care,assisting clinical decision making and optimizing patient communication.The role of ChatGPT in ophth...ChatGPT technology based on large language models(LLM)shows great potential in improving the quality of medical care,assisting clinical decision making and optimizing patient communication.The role of ChatGPT in ophthalmology is still in its infancy.This review aims to explore the application prospect of ChatGPT in ophthalmology.Relevant literature was reviewed and analyzed,and the application prospects of LLM represented by ChatGPT in ophthalmology were summarized,including clinical assisted diagnosis,patient education and communication,history collection and text writing,clinical research,and medical education,etc.At the same time,the challenges and solutions faced by ChatGPT in ophthalmology were pointed out.Its safety,efficacy and ethics remain controversial in practical applications.Therefore,it is necessary to strengthen the supervision and research on its application to ensure safety and effectiveness.In the future,with the development of technology,ChatGPT is expected to play a greater role in ophthalmology and enhance the medical experience.展开更多
Exploration budgets for primary battery metals-nickel,lithium and cobalt-tempered in 2024 at$1.697 billion,reflecting a marginal 0.4%decline and a virtually flat annual total,compared to$1.704 billion in 2023.Below is...Exploration budgets for primary battery metals-nickel,lithium and cobalt-tempered in 2024 at$1.697 billion,reflecting a marginal 0.4%decline and a virtually flat annual total,compared to$1.704 billion in 2023.Below is an introduction to the 2024 global exploration trends and prospects for lithium,cobalt,and nickel battery metals.展开更多
Geographic Information System(GIS)layers contain both spatial precision and domain knowledge,making them valuable for mineral prospectivity analysis.This study proposes a task-oriented methodology to struct con-a mine...Geographic Information System(GIS)layers contain both spatial precision and domain knowledge,making them valuable for mineral prospectivity analysis.This study proposes a task-oriented methodology to struct con-a mineral prospecting knowledge graph directly from GIS maps.The framework integrates ontology construction,spatiotemporal semantic embedding,and triple confidence evaluation.Ontologies are built from GIS layers through terminology extraction and alignment with existing standards,while spatial and temporal semantics are encoded using GeoSPARQL and the Geological Time Ontology.Graph Convolutional Networks(GCN)combined with the TransE embedding model are then applied to assess triple plausibility.A case study in the Eastern Tianshan region of Xinjiang verifies the effectiveness of the proposed method through semantic evaluation and graph-theoretic analysis.Guided by GIS,ontology construction significantly enhances the semantic fidelity and structural robustness of the prospecting knowledge graph,providing relatively reliable support for subsequent reasoning and predictive studies.展开更多
With the accelerating pace of population aging in China,various issues related to elderly care have emerged one after another,becoming a severe social problem.Especially against the backdrop of increasing economic pre...With the accelerating pace of population aging in China,various issues related to elderly care have emerged one after another,becoming a severe social problem.Especially against the backdrop of increasing economic pressure,the traditional family-based elderly care model is facing significant challenges and can hardly meet the elderly care needs.At present,the geriatric nursing models are relatively backward,which directly affects the quality of daily life,physical health and mental well-being of the elderly.Therefore,it is necessary to explore an appropriate geriatric nursing model to address the aging problem.Based on this,this paper analyzes and studies the current situation of geriatric nursing models under the background of healthy aging,providing references for relevant research and practice.展开更多
In this paper,the research status of industrial ecology abroad is briefly introduced,and the development status of industrial ecology in China is summarized and evaluated,including research content,methods,application...In this paper,the research status of industrial ecology abroad is briefly introduced,and the development status of industrial ecology in China is summarized and evaluated,including research content,methods,applications,etc.At the same time,combined with the current needs of China s economic-social development,it looks forward to the future development direction and application prospects of industrial ecology.In the coming period,research on green transformation technologies for industrial structure and production methods,carbon peak routes and carbon reduction implementation paths for industrial systems,key technologies for adapting to climate change and achieving carbon peak and carbon neutrality in priority areas,cross regional collaborative technologies for industrial chains,regional energy resource optimization and allocation technologies,efficient industrial agglomeration and collaboration technologies,multimedia composite pollution collaborative governance technologies,collaborative governance technologies for pollution and carbon reduction,multimedia comprehensive governance of multiple pollutants,and empirical theoretical systems of industrial ecology with Chinese characteristics will be the direction of industrial ecology research in China.展开更多
BACKGROUND Attention deficit hyperactivity disorder(ADHD)affects approximately 5%of children worldwide and is associated with significant academic impairment.Parents of children with ADHD experience elevated stress an...BACKGROUND Attention deficit hyperactivity disorder(ADHD)affects approximately 5%of children worldwide and is associated with significant academic impairment.Parents of children with ADHD experience elevated stress and anxiety levels,which may further affect their children's educational outcomes.This prospective study examined the relationship between parental anxiety and academic performance of children with ADHD over a 6-year period.AIM To investigate the longitudinal impact of parental anxiety on academic performance in children with ADHD and explore the mediating and moderating factors over a 6-year follow-up period.METHODS A longitudinal cohort study was conducted from 2018 to 2024,enrolling 118 children with ADHD(aged 6-12 years)and their parents from three specialized educational centers.Parental anxiety was assessed using the Parenting Stress Index-4(PSI-4)and Parental Anxiety Scale.Children's academic performance was measured using the Academic Performance Questionnaire and standardized achievement tests.Assessments were conducted at baseline and every 6 months for 3 years.RESULTS Higher parental anxiety scores were significantly associated with poorer academic performance in children with ADHD(β=-0.42,P<0.001).Children of parents with clinically significant anxiety(PSI-4 scores>85th percentile)showed 1.2 standard deviations lower academic achievement than children of parents with normal anxiety levels.The relationship was partially mediated by parent-child interaction quality(indirect effect=-0.18,95%CI:-0.26 to-0.10)and homework supervision practices(indirect effect=-0.15,95%CI:-0.22 to-0.08).CONCLUSION Parental anxiety could significantly affect the academic outcomes of children with ADHD via multiple pathways.Interventions targeting parental mental health may improve the educational outcomes of children with ADHD.展开更多
This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus(T2DM).Data were derived from a prospective cohort study enrolling 13776Chine...This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus(T2DM).Data were derived from a prospective cohort study enrolling 13776Chinese patients with T2DM.A healthy lifestyle pattern was constructed based on six lifestyle factors,including smoking status,alcohol consumption,dietary habits,physical activity,sedentary time,and sleep duration.Multivariate Cox proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for all-cause and cause-specific mortality.During a median follow-up of 9.78 years,2497 deaths were recorded.Compared with T2DM patients with a lifestyle pattern scoring 0–2,those scoring 5–6 had a 40%lower risk for all-cause mortality(HR=0.60,95%CI:0.52–0.69),a 33%lower risk for cardiovascular disease mortality(HR=0.67,95%CI:0.52–0.86),and a 25%lower risk for cancer mortality(HR=0.75,95%CI:0.58–0.97).Additionally,we found that the association between the lifestyle pattern and all-cause mortality risk was stronger in females than in males(P for interaction<0.05).In conclusion,adherence to a healthy lifestyle pattern is associated with a decreased risk of all-cause,cardiovascular disease,and cancer mortality.These findings have important implications for reducing premature mortality among patients with T2DM.展开更多
This prospective study aimed to investigate the associations of untreated cholesterol levels and their longitudinal changes,especially low levels,with all-cause and cause-specific mortality in different populations.Pa...This prospective study aimed to investigate the associations of untreated cholesterol levels and their longitudinal changes,especially low levels,with all-cause and cause-specific mortality in different populations.Participants were drawn from two Chinese cohorts and the UK Biobank,excluding those with lipid-lowering medications,coronary heart disease(CHD),stroke,cancer,clinically diagnosed chronic obstructive pulmonary disease,low body mass index(<18.5 kg·m^(-2))at baseline,and deaths within the first two years to minimize reverse causality.Individual cholesterol changes were assessed in a subset who attended the resurvey after over four years.Mortality data were linked to registries,and risks were estimated using Cox proportional hazards models.A total of 163115 Chinese and 317305 UK adults were included(mean age,49-61 years),with 43%,81%,and 44%males in Dongfeng-Tongji,Kailuan,and UK Biobank cohorts,respectively.During a median follow-up of 9.7-12.9 years,9553 and 15760 deaths were documented in the Chinese cohorts and UK Biobank,respectively.After multivariate adjustments,nonlinear relationships were observed between total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and non-high-density lipoprotein cholesterol(non-HDL-C)levels and mortality.In both populations,high cholesterol was primarily associated with CHD mortality,while low cholesterol associated with all-cause and cancer mortality(Pnonlinear≤0.0161).The optimal levels for all-cause mortality risk in Chinese adults(TC:200 mg·dL^(-1);LDL-C:130 mg·dL^(-1);non-HDL-C:155 mg·dL^(-1))were lower than those in the UK Biobank but consistent with guideline recommendation.Additionally,decreasing cholesterol levels over four years were associated with higher all-cause and cancer mortality in the Chinese cohorts(P_(nonlinear)≤0.0100).Participants with low TC,LDL-C,or non-HDL-C levels at both baseline and resurvey experienced elevated all-cause mortality risks in both populations,as did those with low/medium baseline levels and>20%reductions over time in Chinese adults.In conclusion,higher TC,LDL-C,and non-HDL-C levels are associated with elevated CHD mortality.Importantly,low and/or longitudinally decreasing cholesterol levels are robustly associated with increased all-cause and cancer mortality,potentially serving as markers of premature death.Regular cholesterol monitoring,with attention to both high and low levels,is recommended to inform guideline updates and clinical strategies.展开更多
基金the Research Project of the Chinese Digestive Early Cancer Physicians’Joint Growth Program,No.GTCZ-2021-AH-34-0012.
文摘BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gastric mucosa and provide valuable guidance for improving treatment efficacy.METHODS A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included.Among them,296 patients were followed up with endoscopic and biopsy pathology.Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.RESULTS The distribution sites of LGIN among the 357 patients were as follows:Gastric antrum(54.6%),gastric cardia(24.1%),gastric angulus(8.7%),gastric body(4.8%),gastric fundus(4.8%),and multiple sites(3.1%).Additionally,of the 357 patients with LGIN,112(31.4%)developed ulceration and 59(16.5%)experienced gastric polyps.Furthermore,231 of the 357(64.71%)patients with LGIN tested positive for Helicobacter pylori(H.pylori)infection.The H.pylori infection rates of the patients with LGIN with accompanying atrophy,intestinal metaplasia,and gastric ulcer were 51.95%,59.31%,and 28.57%,respectively.Multivariate logistic regression analysis showed that age≥60 years[odds ratio(OR)=3.063,95%confidence interval(CI):1.351-6.945,P=0.007],H.pylori infection(OR=3.560,95%CI:1.158-10.949,P=0.027),multiple locations(OR=10.136,95%CI:2.045-50.237,P=0.005),lesion size≥2 cm(OR=3.921,95%CI:1.664-9.237,P=0.002),and gastric ulcer(OR=2.730,95%CI:1.197-6.223,P=0.017)were predictive factors for LGIN progression.CONCLUSION LGIN progression is closely related to age,H.pylori positivity,multiple locations,lesion size≥2 cm,and gastric ulcer.Thus,actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression.
文摘Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.
文摘Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affected by many factors, including fracture type, prosthesis stability, patient age and comorbidities, and individualized treatment strategy is needed. In recent years, the internal fixation technology and prosthetic revision technology have made significant progress in surgical treatment, such as locking steel plate, titanium cable and bridge combined internal fixation system and other new technologies have effectively improved the treatment effect. In addition, the application of new materials and 3D printing technology, as well as the optimization of multidisciplinary cooperation mode, also provide new ideas for the treatment of complex fractures. However, there are still some problems such as inaccurate diagnosis, difficult choice of treatment options and high incidence of postoperative complications. In the future, technological innovation, the introduction of artificial intelligence and big data, and the further development of personalized treatment will bring more possibilities to improve the prognosis and quality of life of patients. This study summarizes the relevant research results and prospects the future development direction, providing references for clinical practice and subsequent research.
基金Beijing Municipal Administration of Hospitals Incubating Program,No.PZ20200272018 Beijing Talent Incubating Funding,No.2018-4+3 种基金National Natural Science Foundation of China,No.81773214Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support,No.ZYLX202116the National Key R&D Program of China,No.2021YFF1201104Science Foundation of Peking University Cancer Hospital-2023,No.JC202310.
文摘BACKGROUND Stoma creation is a common procedure in colorectal cancer surgery,however,stoma-related complications remain a significant concern.AIM To investigate the incidence,types,and risk factors of stoma-related complications in colorectal cancer patients who underwent stoma creation.METHODS Patients with stoma was prospectively recorded in the established stoma system.Data was collected from this stoma management system from November 2021 through May 2024.The rates of stoma-related complications were assessed,and potential risk factors were analyzed using univariate and multivariate logistic regression models.RESULTS A total of 734 patients were included in the analysis.The results showed that 12.3%of patients experienced stoma-related complications,with mucocutaneous separation,edema,and skin excoriation being the most common complications.The majority(90%)of complications were classified as grade 2 according to the Clavien-Dindo classification.Surgical factors,such as blood loss volume greater than 500 mL and open surgery,were significantly associated with stoma complications.Additionally,stoma features like location,shape,color,height,and edema were important factors in the association with complications.Body mass index over 30 kg/m²was also found to be a significant risk factor.CONCLUSION These findings highlight the need for a holistic approach to preventing and managing stoma complications,considering both patient-related and surgical factors.
基金support from the Nuclear Fuel Pellet Appearance Quality Inspection Device Project(20190304 A).
文摘Thefield of energy storage devices is primarily dominated by lithium-ion batteries(LIBs)due to their mature manufacturing processes and stable performance.However,immature lithium recovery technology cannot stop the continuous increase in the cost of LIBs.Along with the rapid development of electric transportation,it has become inevitable to trigger a new round of competition in alternative energy storage systems.Some monovalent rechargeable metal ion batteries(sodium ion batteries(SIBs)and potassium ion batteries(PIBs),etc.)and multi-valent rechargeable metal-ion batteries(magnesium ion batteries(MIBs),calcium ion batteries(CIBs),zinc ion batteries(ZIBs),and aluminum ion batteries(AIBs),etc.)are potential candidates,which can replace LIBs in some of the scenarios to alleviate the pressure on supply.The cathode material plays a crucial role in determining the battery capacity.Transition metal compounds dominated by layered transition metal oxides as key cathode materials for secondary batteries play an important role in the advancement of various battery energy storage systems.In summary,this manuscript aims to review and summarize the research progress on transition metal compounds used as cathodes in different metal ion batteries,with the aim of providing valuable guidance for the exploration and design of high-performance integrated battery systems.
文摘Hydrogen energy has long been considered an ideal green energy,and in particular,developed with great enthusiasm in recent years[1].To utilize hydrogen energy,efficient hydrogen storage(H-storage)and transportation are necessary.Although great progress has been achieved in H-storage by using high-pressure cylinder up to 70 MPa.
文摘The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helping in building country’s brand value,image and identity.Eritrea has huge tourism potential owing to its natural,historical and cultural endowments.However,the tourism industry in Eritrea is only in its nascent stage.This study,therefore,try to identify and examine the major challenges of sustainable tourism development and its prospects.Primary data were collected from interview with different Ministry of Tourism authorities,travel agencies and tour operators’managers and owners.Secondary data were retrieved from annual reports of international tourism organizations,Ministry of Tourism,the State of Eritrea and other documented sources including magazines and relevant research and papers.The research concludes that Eritrea has great potential for the development of tourism.However,the tourism growth is blocked by specific factors such as poor image,inadequate tourism infrastructural and technological facilities,absence of coordination among tourism stakeholders and lack of skilled man power.This study will assist policymakers to understand the present challenges of the tourism industry and provide necessary recommendations to adopt appropriate strategies and mechanisms.
基金supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)[grant number 2021-I2M-1-037]the National Natural Science Foundation of China[grant numbers 82373647,and 82473697].
文摘Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospective study was conducted at four sites in rural China between 2013 and 2023.Multivariate Cox proportional hazards models and restricted cubic spline analyses were used to assess the association between BMI and mortality.Stratified analyses were performed based on the individual characteristics of the participants.Results Overall,19,107 participants with a sum of 163,095 person-years were included and 1,910 participants died.The underweight(<18.5 kg/m^(2))presented an increase in all-cause mortality(adjusted hazards ratio[aHR]=2.00,95%confidence interval[CI]:1.66–2.41),while overweight(≥24.0 to<28.0 kg/m^(2))and obesity(≥28.0 kg/m^(2))presented a decrease with an aHR of 0.61(95%CI:0.52–0.73)and 0.51(95%CI:0.37–0.70),respectively.Overweight(aHR=0.76,95%CI:0.67–0.86)and mild obesity(aHR=0.72,95%CI:0.59–0.87)had a positive impact on mortality in people older than 60 years.All-2 cause mortality decreased rapidly until reaching a BMI of 25.7 kg/m(aHR=0.95,95%CI:0.92–0.98)and increased slightly above that value,indicating a U-shaped association.The beneficial impact of being overweight on mortality was robust in most subgroups and sensitivity analyses.Conclusion This study provides additional evidence that overweight and mild obesity may be inversely related to the risk of death in individuals older than 60 years.Therefore,it is essential to consider age differences when formulating health and weight management strategies.
基金supported by the Higher Institution Centre of Excellence(HICoE)program(MO002-2019&TIDREC-2023)funded by the Bernhard Nocht Institute for Tropical Medicine,Hamburg,Germany[100-TNCPI/INT 16/6/2(005/2020)].
文摘Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primarily conducted by European scientists and curators,establishing the foundation for tick taxonomy in the region.Pioneering works by George Henry Falknier Nuttall and Cecil Warburton introduced several new tick species,including Haemaphysalis(H.)calva,H.mjoebergi,H.vidua and H.wellingtoni[1].However,some records from this period are now considered doubtful,for instance Amblyomma(A.)breviscutatum,A.clypeolatum and A.integrum.The 1929 description of Ornithodoros batuensis by Stanley Hirst[2]marked the first documentation of a soft tick species in Malaysia,setting the stage for subsequent research endeavours.The Golden Age of tick studies(early 1950s-late 1980s)in Malaysia saw a surge in tick research activities.
基金Supported by the Hainan Provincial Natural Science Foundation of China(No.825RC898)and Hainan Province Clinical Medical Center.
文摘ChatGPT technology based on large language models(LLM)shows great potential in improving the quality of medical care,assisting clinical decision making and optimizing patient communication.The role of ChatGPT in ophthalmology is still in its infancy.This review aims to explore the application prospect of ChatGPT in ophthalmology.Relevant literature was reviewed and analyzed,and the application prospects of LLM represented by ChatGPT in ophthalmology were summarized,including clinical assisted diagnosis,patient education and communication,history collection and text writing,clinical research,and medical education,etc.At the same time,the challenges and solutions faced by ChatGPT in ophthalmology were pointed out.Its safety,efficacy and ethics remain controversial in practical applications.Therefore,it is necessary to strengthen the supervision and research on its application to ensure safety and effectiveness.In the future,with the development of technology,ChatGPT is expected to play a greater role in ophthalmology and enhance the medical experience.
文摘Exploration budgets for primary battery metals-nickel,lithium and cobalt-tempered in 2024 at$1.697 billion,reflecting a marginal 0.4%decline and a virtually flat annual total,compared to$1.704 billion in 2023.Below is an introduction to the 2024 global exploration trends and prospects for lithium,cobalt,and nickel battery metals.
基金supported by the Natural Science Foundation of Jilin Province(20220101114JC).
文摘Geographic Information System(GIS)layers contain both spatial precision and domain knowledge,making them valuable for mineral prospectivity analysis.This study proposes a task-oriented methodology to struct con-a mineral prospecting knowledge graph directly from GIS maps.The framework integrates ontology construction,spatiotemporal semantic embedding,and triple confidence evaluation.Ontologies are built from GIS layers through terminology extraction and alignment with existing standards,while spatial and temporal semantics are encoded using GeoSPARQL and the Geological Time Ontology.Graph Convolutional Networks(GCN)combined with the TransE embedding model are then applied to assess triple plausibility.A case study in the Eastern Tianshan region of Xinjiang verifies the effectiveness of the proposed method through semantic evaluation and graph-theoretic analysis.Guided by GIS,ontology construction significantly enhances the semantic fidelity and structural robustness of the prospecting knowledge graph,providing relatively reliable support for subsequent reasoning and predictive studies.
文摘With the accelerating pace of population aging in China,various issues related to elderly care have emerged one after another,becoming a severe social problem.Especially against the backdrop of increasing economic pressure,the traditional family-based elderly care model is facing significant challenges and can hardly meet the elderly care needs.At present,the geriatric nursing models are relatively backward,which directly affects the quality of daily life,physical health and mental well-being of the elderly.Therefore,it is necessary to explore an appropriate geriatric nursing model to address the aging problem.Based on this,this paper analyzes and studies the current situation of geriatric nursing models under the background of healthy aging,providing references for relevant research and practice.
基金Supported by the National Natural Science Foundation of China(42477521).
文摘In this paper,the research status of industrial ecology abroad is briefly introduced,and the development status of industrial ecology in China is summarized and evaluated,including research content,methods,applications,etc.At the same time,combined with the current needs of China s economic-social development,it looks forward to the future development direction and application prospects of industrial ecology.In the coming period,research on green transformation technologies for industrial structure and production methods,carbon peak routes and carbon reduction implementation paths for industrial systems,key technologies for adapting to climate change and achieving carbon peak and carbon neutrality in priority areas,cross regional collaborative technologies for industrial chains,regional energy resource optimization and allocation technologies,efficient industrial agglomeration and collaboration technologies,multimedia composite pollution collaborative governance technologies,collaborative governance technologies for pollution and carbon reduction,multimedia comprehensive governance of multiple pollutants,and empirical theoretical systems of industrial ecology with Chinese characteristics will be the direction of industrial ecology research in China.
文摘BACKGROUND Attention deficit hyperactivity disorder(ADHD)affects approximately 5%of children worldwide and is associated with significant academic impairment.Parents of children with ADHD experience elevated stress and anxiety levels,which may further affect their children's educational outcomes.This prospective study examined the relationship between parental anxiety and academic performance of children with ADHD over a 6-year period.AIM To investigate the longitudinal impact of parental anxiety on academic performance in children with ADHD and explore the mediating and moderating factors over a 6-year follow-up period.METHODS A longitudinal cohort study was conducted from 2018 to 2024,enrolling 118 children with ADHD(aged 6-12 years)and their parents from three specialized educational centers.Parental anxiety was assessed using the Parenting Stress Index-4(PSI-4)and Parental Anxiety Scale.Children's academic performance was measured using the Academic Performance Questionnaire and standardized achievement tests.Assessments were conducted at baseline and every 6 months for 3 years.RESULTS Higher parental anxiety scores were significantly associated with poorer academic performance in children with ADHD(β=-0.42,P<0.001).Children of parents with clinically significant anxiety(PSI-4 scores>85th percentile)showed 1.2 standard deviations lower academic achievement than children of parents with normal anxiety levels.The relationship was partially mediated by parent-child interaction quality(indirect effect=-0.18,95%CI:-0.26 to-0.10)and homework supervision practices(indirect effect=-0.15,95%CI:-0.22 to-0.08).CONCLUSION Parental anxiety could significantly affect the academic outcomes of children with ADHD via multiple pathways.Interventions targeting parental mental health may improve the educational outcomes of children with ADHD.
基金supported by the Jiangsu Provincial Health Commission Medical Research Project(Grant Nos.M2020085 to J.S.and H2023022 to X.F.)the Outstanding Youth Fund of Jiangsu Natural Science Foundation(Grant No.BK20230005 to D.H.)Suzhou Science and Technology Bureau Livelihood Technology-Technology Demonstration Project(Grant No.SS202010 to Y.L.)。
文摘This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus(T2DM).Data were derived from a prospective cohort study enrolling 13776Chinese patients with T2DM.A healthy lifestyle pattern was constructed based on six lifestyle factors,including smoking status,alcohol consumption,dietary habits,physical activity,sedentary time,and sleep duration.Multivariate Cox proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for all-cause and cause-specific mortality.During a median follow-up of 9.78 years,2497 deaths were recorded.Compared with T2DM patients with a lifestyle pattern scoring 0–2,those scoring 5–6 had a 40%lower risk for all-cause mortality(HR=0.60,95%CI:0.52–0.69),a 33%lower risk for cardiovascular disease mortality(HR=0.67,95%CI:0.52–0.86),and a 25%lower risk for cancer mortality(HR=0.75,95%CI:0.58–0.97).Additionally,we found that the association between the lifestyle pattern and all-cause mortality risk was stronger in females than in males(P for interaction<0.05).In conclusion,adherence to a healthy lifestyle pattern is associated with a decreased risk of all-cause,cardiovascular disease,and cancer mortality.These findings have important implications for reducing premature mortality among patients with T2DM.
基金supported by the National Natural Science Foundation of China(82021005,82192903,81930092)the Chief Scientist Research Project of Hubei Shizhen Laboratory(HSL2024SX0003)+1 种基金the Fundamental Research Funds for the Central Universities(2019kfyXMBZ015)the 111 Project and the Program for Changjiang Scholars and Innovative Research Team in University.
文摘This prospective study aimed to investigate the associations of untreated cholesterol levels and their longitudinal changes,especially low levels,with all-cause and cause-specific mortality in different populations.Participants were drawn from two Chinese cohorts and the UK Biobank,excluding those with lipid-lowering medications,coronary heart disease(CHD),stroke,cancer,clinically diagnosed chronic obstructive pulmonary disease,low body mass index(<18.5 kg·m^(-2))at baseline,and deaths within the first two years to minimize reverse causality.Individual cholesterol changes were assessed in a subset who attended the resurvey after over four years.Mortality data were linked to registries,and risks were estimated using Cox proportional hazards models.A total of 163115 Chinese and 317305 UK adults were included(mean age,49-61 years),with 43%,81%,and 44%males in Dongfeng-Tongji,Kailuan,and UK Biobank cohorts,respectively.During a median follow-up of 9.7-12.9 years,9553 and 15760 deaths were documented in the Chinese cohorts and UK Biobank,respectively.After multivariate adjustments,nonlinear relationships were observed between total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and non-high-density lipoprotein cholesterol(non-HDL-C)levels and mortality.In both populations,high cholesterol was primarily associated with CHD mortality,while low cholesterol associated with all-cause and cancer mortality(Pnonlinear≤0.0161).The optimal levels for all-cause mortality risk in Chinese adults(TC:200 mg·dL^(-1);LDL-C:130 mg·dL^(-1);non-HDL-C:155 mg·dL^(-1))were lower than those in the UK Biobank but consistent with guideline recommendation.Additionally,decreasing cholesterol levels over four years were associated with higher all-cause and cancer mortality in the Chinese cohorts(P_(nonlinear)≤0.0100).Participants with low TC,LDL-C,or non-HDL-C levels at both baseline and resurvey experienced elevated all-cause mortality risks in both populations,as did those with low/medium baseline levels and>20%reductions over time in Chinese adults.In conclusion,higher TC,LDL-C,and non-HDL-C levels are associated with elevated CHD mortality.Importantly,low and/or longitudinally decreasing cholesterol levels are robustly associated with increased all-cause and cancer mortality,potentially serving as markers of premature death.Regular cholesterol monitoring,with attention to both high and low levels,is recommended to inform guideline updates and clinical strategies.
