Underground construction in China is featured by large scale, high speed, long construction period,complex operation and frustrating situations regarding project safety. Various accidents have been reported from time ...Underground construction in China is featured by large scale, high speed, long construction period,complex operation and frustrating situations regarding project safety. Various accidents have been reported from time to time, resulting in serious social impact and huge economic loss. This paper presents the main progress in the safety risk management of underground engineering in China over the last decade, i.e.（1） establishment of laws and regulations for safety risk management of underground engineering,（2） implementation of the safety risk management plan,（3） establishment of decision support system for risk management and early-warning based on information technology, and（4） strengthening the study on safety risk management, prediction and prevention. Based on the analysis of the typical accidents in China in the last decade, the new challenges in the safety risk management for underground engineering are identified as follows：（1） control of unsafe human behaviors;（2） technological innovation in safety risk management; and（3） design of safety risk management regulations. Finally, the strategies for safety risk management of underground engineering in China are proposed in six aspects, i.e. the safety risk management system and policy, law, administration, economy, education and technology.展开更多
The concept of labor division and multi-module cooperation of microbial consortia offers it promising potentials in various areas,such as the utilization of complex substrates,synthesis of natural compounds with long ...The concept of labor division and multi-module cooperation of microbial consortia offers it promising potentials in various areas,such as the utilization of complex substrates,synthesis of natural compounds with long metabolic pathways and remediation of environmental pollutants within a hostile environment.Consequently,synthetic microbial consortia represent a new frontier for synthetic biology because they can solve more complex problems than monocultures.However,current research on microbial consortia often involves the simple mixing of multiphase systems,where strains are co-cultured sequentially or individually cultured and then mixed-cultured.The instability and low efficiency of microbial consortia systems hindered their practical application.To construct a stable and efficient microbial consortium,it is essential to consider the different growth and metabolic characteristics of strains,the competition for various nutrients as well as the complex carbon,energy and signaling dynamics within the system.In this review,we provide a progressive strategy for constructing a stable and efficient microbial consortium system across three stages:compromised stage(work together),microenvironment-oriented stage(work better),and metabolite delivery-enhanced stage(work best).The detailed methods and points for attention of each stage are summarized,with a highlight on the technical bottleneck and application limitations.Through the integration of interdisciplinary strategies,such as materials science and mathematical models,the goal of building a stable and efficient microbial consortium is constantly advanced.展开更多
Alzheimer＇s disease （AD）, a fatal, progressive, neurodegener- ative disorder, is the most common cause of old-age demen- tia, accounting for 50-75% of dementia patients. Early stages of AD are marked by vocabulary ...Alzheimer＇s disease （AD）, a fatal, progressive, neurodegener- ative disorder, is the most common cause of old-age demen- tia, accounting for 50-75% of dementia patients. Early stages of AD are marked by vocabulary shrinkage, spatial disori- entation, depression, apraxia, and deterioration of recent forms of declarative memory. In course of time, the patients require close supervision due to the loss of cognitive and functional abilities, and at the terminal stages of the disease, all forms of memory are severely impaired with the patients needing nursing home care （World Alzheimer Report, 2013）.展开更多
I. Preface
Biomass includes the residues of agriculture, forest and stock breeding, as well as straw, algae and energy crops. In its broad meaning, biomass is a kind of organic matter produced by the photosynthesis of...I. Preface
Biomass includes the residues of agriculture, forest and stock breeding, as well as straw, algae and energy crops. In its broad meaning, biomass is a kind of organic matter produced by the photosynthesis of plants, which is not only renewable, but also contains plentiful energy.展开更多
In recent years,learning-based low-light image enhancement methods have shown excellent performance,but the heuristic design adopted by most methods requires high engineering skills for developers,causing expensive in...In recent years,learning-based low-light image enhancement methods have shown excellent performance,but the heuristic design adopted by most methods requires high engineering skills for developers,causing expensive inference costs that are unfriendly to the hardware platform.To handle this issue,we propose to automatically discover an efficient architecture,called progressive attentive Retinex network(PAR-Net).We define a new attentive Retinex framework by introducing the attention mechanism to strengthen structural representation.A multi-level search space containing micro-level on the operation and macro-level on the cell is established to realize meticulous construction.To endow the searched architecture with the hardware-aware property,we develop a latency-constrained progressive search strategy that successfully improves the model capability by explicitly expressing the intrinsic relationship between different models defined in the attentive Retinex framework.Extensive quantitative and qualitative experimental results fully justify the superiority of our proposed approach against other state-of-the-art methods.A series of analytical evaluations is performed to illustrate the validity of our proposed algorithm.展开更多
基金supported by Chinese Academy of Engineering(grant No.2011-ZD-12)National Natural Science Foundation of China(grant No.11272178)National Basic Research Program of China(973 Program)(grant No.2011CB013502/3)
文摘Underground construction in China is featured by large scale, high speed, long construction period,complex operation and frustrating situations regarding project safety. Various accidents have been reported from time to time, resulting in serious social impact and huge economic loss. This paper presents the main progress in the safety risk management of underground engineering in China over the last decade, i.e.（1） establishment of laws and regulations for safety risk management of underground engineering,（2） implementation of the safety risk management plan,（3） establishment of decision support system for risk management and early-warning based on information technology, and（4） strengthening the study on safety risk management, prediction and prevention. Based on the analysis of the typical accidents in China in the last decade, the new challenges in the safety risk management for underground engineering are identified as follows：（1） control of unsafe human behaviors;（2） technological innovation in safety risk management; and（3） design of safety risk management regulations. Finally, the strategies for safety risk management of underground engineering in China are proposed in six aspects, i.e. the safety risk management system and policy, law, administration, economy, education and technology.
基金supported by the National Key Research and Development Program of China(2022YFC2104800)the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(XTD2205)the State Key Laboratory of Materials-Oriented Chemical Engineering(KL-MCE-23A10).
文摘The concept of labor division and multi-module cooperation of microbial consortia offers it promising potentials in various areas,such as the utilization of complex substrates,synthesis of natural compounds with long metabolic pathways and remediation of environmental pollutants within a hostile environment.Consequently,synthetic microbial consortia represent a new frontier for synthetic biology because they can solve more complex problems than monocultures.However,current research on microbial consortia often involves the simple mixing of multiphase systems,where strains are co-cultured sequentially or individually cultured and then mixed-cultured.The instability and low efficiency of microbial consortia systems hindered their practical application.To construct a stable and efficient microbial consortium,it is essential to consider the different growth and metabolic characteristics of strains,the competition for various nutrients as well as the complex carbon,energy and signaling dynamics within the system.In this review,we provide a progressive strategy for constructing a stable and efficient microbial consortium system across three stages:compromised stage(work together),microenvironment-oriented stage(work better),and metabolite delivery-enhanced stage(work best).The detailed methods and points for attention of each stage are summarized,with a highlight on the technical bottleneck and application limitations.Through the integration of interdisciplinary strategies,such as materials science and mathematical models,the goal of building a stable and efficient microbial consortium is constantly advanced.
基金in part supported by the German Ministry for Education and Research (BMBF) special network program KMU-Innovativ-2
文摘Alzheimer＇s disease （AD）, a fatal, progressive, neurodegener- ative disorder, is the most common cause of old-age demen- tia, accounting for 50-75% of dementia patients. Early stages of AD are marked by vocabulary shrinkage, spatial disori- entation, depression, apraxia, and deterioration of recent forms of declarative memory. In course of time, the patients require close supervision due to the loss of cognitive and functional abilities, and at the terminal stages of the disease, all forms of memory are severely impaired with the patients needing nursing home care （World Alzheimer Report, 2013）.
文摘I. Preface
Biomass includes the residues of agriculture, forest and stock breeding, as well as straw, algae and energy crops. In its broad meaning, biomass is a kind of organic matter produced by the photosynthesis of plants, which is not only renewable, but also contains plentiful energy.
文摘In recent years,learning-based low-light image enhancement methods have shown excellent performance,but the heuristic design adopted by most methods requires high engineering skills for developers,causing expensive inference costs that are unfriendly to the hardware platform.To handle this issue,we propose to automatically discover an efficient architecture,called progressive attentive Retinex network(PAR-Net).We define a new attentive Retinex framework by introducing the attention mechanism to strengthen structural representation.A multi-level search space containing micro-level on the operation and macro-level on the cell is established to realize meticulous construction.To endow the searched architecture with the hardware-aware property,we develop a latency-constrained progressive search strategy that successfully improves the model capability by explicitly expressing the intrinsic relationship between different models defined in the attentive Retinex framework.Extensive quantitative and qualitative experimental results fully justify the superiority of our proposed approach against other state-of-the-art methods.A series of analytical evaluations is performed to illustrate the validity of our proposed algorithm.
