Let a_(1),a_(2),a_(3)be nonzero integers with gcd(a_(1),a_(2),a_(3))=1,and let k be any positive integer,K=max[3,|a_(1)|,|a_(2)|,|a_(3)|,k].Suppose that l_(1),l_(2),l_(3)are integers each coprime to k.Suppose further ...Let a_(1),a_(2),a_(3)be nonzero integers with gcd(a_(1),a_(2),a_(3))=1,and let k be any positive integer,K=max[3,|a_(1)|,|a_(2)|,|a_(3)|,k].Suppose that l_(1),l_(2),l_(3)are integers each coprime to k.Suppose further that b is any integer satisfying some necessary congruent conditions.The solvability of linear equation a_(1)p_(1)+a_(2)p_(2)+a_(3)p_(3)=b(p_(j)=l_(j)(mod k),1≤j≤3)with prime variables pi,p_(2),ps is investigated.It is proved that if ai,a_(2),a_(3)are all positive,then the above equation is solvable whenever b≥K^(25);if a,a_(2),a_(3)are not all of the same sign,then the above equation has a solution p_(1),p_(2),p_(3)satisfying max(p_(1),p_(2),p_(3))≤3|b|+K^(25).展开更多
Let φ(n) denote the Euler-totient function, we study the distribution of solutions of φ(n) ≤ x in arithmetic progressions, where n ≡ l(mod q) and an asymptotic formula was obtained by Perron formula.
Recently Elliott studied the distribution of primes in arithmetic progressions whose moduli can be divisible by highpowers of a given integer and showed that for integer a≥2 and real number A>0. There is a B=B(A)&...Recently Elliott studied the distribution of primes in arithmetic progressions whose moduli can be divisible by highpowers of a given integer and showed that for integer a≥2 and real number A>0. There is a B=B(A)>0 such that , holds uniformly for moduli that are powers of a. In this paper we are able to improve his result.展开更多
Learning progressions divide the logical system of a subject into ordered and continuously developing levels that are suitable for the cognitive development level of students,which plays an important role in understan...Learning progressions divide the logical system of a subject into ordered and continuously developing levels that are suitable for the cognitive development level of students,which plays an important role in understanding students’learning process.This paper focuses on the theme of“kinetic energy”in high school physics as the research object.Firstly,the concept map was used to represent the relationship between knowledge,and then five core concepts were selected based on the opinions of high school teachers.Secondly,the test tools were compiled and tested based on the relevant test questions.Finally,the paper analyzed the results based on the Rasch model,clarified students’cognitive development level of“kinetic energy”and constructed the learning progressions of“kinetic energy”based on the logical order of subject knowledge.The research provides theoretical and methodological support for the study of other subjects and learning progressions,and provides a valuable reference for high school teachers to effectively carry out the instruction of“kinetic energy.”展开更多
For any x ∈ （0, 1] （except at most countably many points）, there exists a unique sequence {dn（x）}n≥1 of integers, called the digit sequence of x, such that x =∞ ∑j=1 1/d1（x）（d1（x）-1）……dj-1（x）（dj-1...For any x ∈ （0, 1] （except at most countably many points）, there exists a unique sequence {dn（x）}n≥1 of integers, called the digit sequence of x, such that x =∞ ∑j=1 1/d1（x）（d1（x）-1）……dj-1（x）（dj-1（x）-1）dj（x）. The dexter infinite series expansion is called the Liiroth expansion of x. This paper is con- cerned with the size of the set of points x whose digit sequence in its Liiroth expansion is strictly increasing and contains arbitrarily long arithmetic progressions with arbitrary com- mon difference. More precisely, we determine the Hausdorff dimension of the above set.展开更多
Targeting drug delivery systems mediated by nanoparticles has shown great potential in the diagnosis and treatment of cancer.However,influences of different tumor progressions on the accumulation of nanoparticles,espe...Targeting drug delivery systems mediated by nanoparticles has shown great potential in the diagnosis and treatment of cancer.However,influences of different tumor progressions on the accumulation of nanoparticles,especially the ligand-modified active targeting nanoparticles are seldom exploited.In this work,the accumulation and penetration of RGD-modified gold nanoparticles(active AuNPs)with different sizes were investigated in orthotopic breast cancer with different tumor progressions.The results showed that the smallest active AuNPs had better accumulation and permeation effects in early tumor tissues with the relatively looser extracellular matrix,larger gaps,lower interstitial fluid pressure,and less receptor expression,which was due to size effects.However,the larger active AuNPs had better accumulation and penetration effects in late tumor tissues with highly expressed target receptors integrinαvβ3 because of the multivalent interactions between larger active nanoparticles and integrinαvβ3.In the midterm,tumor accumulation of active AuNPs was equally influenced by size effects and multivalent interactions.Therefore,RGD-modified nanoparticles with sizes of 7 and 90 nm accumulated more in tumors.This study will guide a rational design of active targeting nanoparticles for enhancing the diagnosis and treatment of tumors based on their progressions.展开更多
Let k be a positive integer.Denote by D_(1/k)the least integer d such that for every set A of nonnegative integers with the lower density 1/k,the set(k+1)A contains an infinite arithmetic progression with difference a...Let k be a positive integer.Denote by D_(1/k)the least integer d such that for every set A of nonnegative integers with the lower density 1/k,the set(k+1)A contains an infinite arithmetic progression with difference at most d,where(k+1)A is the set of all sums of k+1 elements(not necessarily distinct)of A.Chen and Li(2019)conjectured that D_(1/k)=k~2+o(k~2).The purpose of this paper is to confirm the above conjecture.We also prove that D_(1/k)is a prime for all sufficiently large integers k.展开更多
In this paper we study the distribution of primes in quadratic progressions on average. Our result improves a previous result of Baier and Zhao in some aspects.
Let(λ_f(n))_(n≥1)be the Hecke eigenvalues of either a holomorphic Hecke eigencuspform or a Hecke-Maass cusp form f.We prove that,for any fixedη>0,under the Ramanujan-Petersson conjecture for GL_(2)Maass forms,th...Let(λ_f(n))_(n≥1)be the Hecke eigenvalues of either a holomorphic Hecke eigencuspform or a Hecke-Maass cusp form f.We prove that,for any fixedη>0,under the Ramanujan-Petersson conjecture for GL_(2)Maass forms,the Rankin-Selberg coefficients(λ_f(n)^(2))_(n≥1)admit a level of distributionθ=2/5+1/260-ηin arithmetic progressions.展开更多
This lecture note is mainly about arithmetic progressions,different regularity lemmas and removal lemmas.We will be very brief most of the time,trying to avoid technical details,even definitions.For most technical det...This lecture note is mainly about arithmetic progressions,different regularity lemmas and removal lemmas.We will be very brief most of the time,trying to avoid technical details,even definitions.For most technical details,we refer the reader to references.Apart from arithmetic progressions,we also discuss property testing and extremal graph theory.展开更多
On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyo...On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.展开更多
Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly ...Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
Yam(Dioscorea opposita)is an important economic crop,and the development of its the cultivation tecchnology is of great significance for increasing yield,improving quality,and reducing the occurrence of pests and dise...Yam(Dioscorea opposita)is an important economic crop,and the development of its the cultivation tecchnology is of great significance for increasing yield,improving quality,and reducing the occurrence of pests and diseases.With the progression of agricultural technology and changes in market demands,the cultivation tecchnology of yam is constantly innovating and improving.This paper reviewed recent research advances in yam cultivation tecchnology,covering aspects such as soil improvement,variety selection,technological innovations,green pest control,and harvesting and storage.The goal is to provide references for the sustainable development of the yam industry.展开更多
AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on diseas...AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.展开更多
BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two...BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two techniques in treatment-naive HCC.AIM To compare the risk of local tumor progression(LTP)according to the technique;secondary endpoints included technique efficacy rate at one-month,overall survival and major complication rate.METHODS A bi-institutional retrospective analysis of patients undergoing treatment-naive HCC ablation by either technique was performed.Inverse probability of treatment weighting was used to compare the two groups.Mixed effects multivariate Cox regression was applied to identify risk factors for LTP.RESULTS A total of 362 patients(mean age,66.1±6.2 years,308 men)were included,of which 242(323 tumors)treated by mbp-RFA and 120(168 tumors)by MWA.After a median follow-up of 27 months,cumulative LTP was 11.4%after mbp-RFA and 25.2%after MWA.Independent risk factors for LTP at multivariate analysis were MWA(hazard ratio=2.85,P<0.001)and tumor size(hazard ratio=1.08,P<0.001).Two-year LTP-free survival was higher after mbp-RFA than MWA regardless of size(<3 cm:96%vs 87.1%,P<0.01;≥3 cm:87.5%vs 74%,P=0.04).Technique efficacy rate was higher after mbp-RFA(94.1%vs 87.5%,P=0.01).No difference was observed in major complication rate(9.5%vs 7.5%,P=0.59),nor 5-year overall survival(63.6%vs 58.3%,P=0.33).CONCLUSION Mbp-RFA leads to better local tumor control of treatment-naïve HCC than MWA regardless of tumor size and has better primary efficacy,while maintaining a comparable safety profile.展开更多
Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemot...Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.展开更多
Objectives:The five-year survival rate for pancreatic cancer is notably low,posing a significant challenge to patient health.The primary treatments are radiotherapy and chemotherapy,sometimes combined with targeted th...Objectives:The five-year survival rate for pancreatic cancer is notably low,posing a significant challenge to patient health.The primary treatments are radiotherapy and chemotherapy,sometimes combined with targeted therapy;however,their clinical benefits are limited.Therefore,developing new models to evaluate the therapeutic potential of novel molecules is essential.Fingolimod and Dimethyl Fumarate(DMF),currently used to treat multiple sclerosis,have recently been shown to have anti-cancer effects in several preclinical tumor models.This study aims to evaluate the therapeutic potential of Fingolimod and DMF in pancreatic cancer by investigating their respective in vitro cytotoxicity and in vivo antitumor effects.Methods:In this study,we evaluated for the first time these two drugs in pancreatic preclinical models in vitro using 3D spheroid tumor models and in vivo,which are compared to two standard-of-care consisting of Gemcitabine and Erlotinib.Results:In vitro,both Fingolimod and DMF induced cytotoxicity in spheroids from two pancreatic cell lines.Additionally,Fingolimod and DMF displayed anticancer effects in two subcutaneous xenograft models using PANC-1 and CFPAC-1 cells.Conclusions:Although the responses observed with Fingolimod and DMF were similar to those of Gemcitabine and Erlotinib,these findings indicate a potential emerging interest in Fingolimod and DMF for the treatment of pancreatic cancer.However,further work is still necessary to fully characterize how these drugs affect tumor progression.展开更多
This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides...This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides an in-depth analysis and summary of the effects of biological factors,environmental conditions,agronomic practices,processing methods,and continuous cropping obstacles on the synthesis of P.heterophylla saponins,as well as their underlying mechanisms.Based on identified gaps in the current literature,future research directions and prospects are proposed.The findings of this review offer valuable insights for advancing the understanding of the saponin biosynthesis mechanisms in P.heterophylla and for enhancing its quality.展开更多
Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge percep...Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge perception,especially under complex dynamic blur.To address these challenges,we propose the Multi-Resolution Fusion Network(MRFNet),a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion.The network employs a three-stage design:(1)TransformerBlocks capture long-range dependencies and reconstruct coarse global structures;(2)Nonlinear Activation Free Blocks(NAFBlocks)enhance local detail representation and mid-level feature fusion;and(3)an optimized residual subnetwork based on gated feature modulation refines texture and edge details for high-fidelity restoration.Extensive experiments demonstrate that MRFNet achieves superior performance compared to state-of-the-art methods.On GoPro,it attains 32.52 dB Peak Signal-to-Noise Ratio(PSNR)and 0.071 Learned Perceptual Image Patch Similarity(LPIPS),outperforming MIMOWNet(32.50 dB,0.075).On HIDE,it achieves 30.25 dB PSNR and 0.945 Structural Similarity Index Measure(SSIM),representing gains of+0.26 dB and+0.015 SSIM over MIMO-UNet(29.99 dB,0.930).On RealBlur-J,it reaches 28.82 dB PSNR and 0.872 SSIM,surpassing MIMO-UNet by+1.19 dB and+0.035 SSIM(27.63 dB,0.837).These results validate the effectiveness of the proposed progressive residual fusion and hybrid attention mechanisms in balancing global context understanding and local detail recovery for blind image deblurring.展开更多
文摘Let a_(1),a_(2),a_(3)be nonzero integers with gcd(a_(1),a_(2),a_(3))=1,and let k be any positive integer,K=max[3,|a_(1)|,|a_(2)|,|a_(3)|,k].Suppose that l_(1),l_(2),l_(3)are integers each coprime to k.Suppose further that b is any integer satisfying some necessary congruent conditions.The solvability of linear equation a_(1)p_(1)+a_(2)p_(2)+a_(3)p_(3)=b(p_(j)=l_(j)(mod k),1≤j≤3)with prime variables pi,p_(2),ps is investigated.It is proved that if ai,a_(2),a_(3)are all positive,then the above equation is solvable whenever b≥K^(25);if a,a_(2),a_(3)are not all of the same sign,then the above equation has a solution p_(1),p_(2),p_(3)satisfying max(p_(1),p_(2),p_(3))≤3|b|+K^(25).
基金Supported by the National Natural Science Foundation of China（11271249） Supported by the Scientific and Technological Research Program of Chongqing Municipal Education Commission（1601213） Supported by the Scientific Research Program of Yangtze Normal University（2012XJYBO31）
文摘Let φ(n) denote the Euler-totient function, we study the distribution of solutions of φ(n) ≤ x in arithmetic progressions, where n ≡ l(mod q) and an asymptotic formula was obtained by Perron formula.
文摘Recently Elliott studied the distribution of primes in arithmetic progressions whose moduli can be divisible by highpowers of a given integer and showed that for integer a≥2 and real number A>0. There is a B=B(A)>0 such that , holds uniformly for moduli that are powers of a. In this paper we are able to improve his result.
基金Jilin Province Education Science“14th Five Year Plan”2021 Annual Project“Research on Middle School Physics Teaching Based on STEM Education Concept”(GH21032).
文摘Learning progressions divide the logical system of a subject into ordered and continuously developing levels that are suitable for the cognitive development level of students,which plays an important role in understanding students’learning process.This paper focuses on the theme of“kinetic energy”in high school physics as the research object.Firstly,the concept map was used to represent the relationship between knowledge,and then five core concepts were selected based on the opinions of high school teachers.Secondly,the test tools were compiled and tested based on the relevant test questions.Finally,the paper analyzed the results based on the Rasch model,clarified students’cognitive development level of“kinetic energy”and constructed the learning progressions of“kinetic energy”based on the logical order of subject knowledge.The research provides theoretical and methodological support for the study of other subjects and learning progressions,and provides a valuable reference for high school teachers to effectively carry out the instruction of“kinetic energy.”
文摘For any x ∈ （0, 1] （except at most countably many points）, there exists a unique sequence {dn（x）}n≥1 of integers, called the digit sequence of x, such that x =∞ ∑j=1 1/d1（x）（d1（x）-1）……dj-1（x）（dj-1（x）-1）dj（x）. The dexter infinite series expansion is called the Liiroth expansion of x. This paper is con- cerned with the size of the set of points x whose digit sequence in its Liiroth expansion is strictly increasing and contains arbitrarily long arithmetic progressions with arbitrary com- mon difference. More precisely, we determine the Hausdorff dimension of the above set.
基金supported by the Science and Technology Innovation Plan Laboratory Animal Research Project of Shanghai(23141900400)the National Natural Science Foundation of China(82172746 and 82473342)International Cooperation Project of Shanghai Science and Technology Innovation Plan(24410741500).
文摘Targeting drug delivery systems mediated by nanoparticles has shown great potential in the diagnosis and treatment of cancer.However,influences of different tumor progressions on the accumulation of nanoparticles,especially the ligand-modified active targeting nanoparticles are seldom exploited.In this work,the accumulation and penetration of RGD-modified gold nanoparticles(active AuNPs)with different sizes were investigated in orthotopic breast cancer with different tumor progressions.The results showed that the smallest active AuNPs had better accumulation and permeation effects in early tumor tissues with the relatively looser extracellular matrix,larger gaps,lower interstitial fluid pressure,and less receptor expression,which was due to size effects.However,the larger active AuNPs had better accumulation and penetration effects in late tumor tissues with highly expressed target receptors integrinαvβ3 because of the multivalent interactions between larger active nanoparticles and integrinαvβ3.In the midterm,tumor accumulation of active AuNPs was equally influenced by size effects and multivalent interactions.Therefore,RGD-modified nanoparticles with sizes of 7 and 90 nm accumulated more in tumors.This study will guide a rational design of active targeting nanoparticles for enhancing the diagnosis and treatment of tumors based on their progressions.
基金supported by National Natural Science Foundation of China(Grant Nos.12171243 and 11922113)the National Key Research and Development Program of China(Grant No.2021YFA1000700)。
文摘Let k be a positive integer.Denote by D_(1/k)the least integer d such that for every set A of nonnegative integers with the lower density 1/k,the set(k+1)A contains an infinite arithmetic progression with difference at most d,where(k+1)A is the set of all sums of k+1 elements(not necessarily distinct)of A.Chen and Li(2019)conjectured that D_(1/k)=k~2+o(k~2).The purpose of this paper is to confirm the above conjecture.We also prove that D_(1/k)is a prime for all sufficiently large integers k.
基金Supported by National Natural Science Foundation of China （Grant No. 10701048）, Shandong Province Natural Science Foundation （Crant No. ZR2009AM007）, and IIFSDU
文摘In this paper we study the distribution of primes in quadratic progressions on average. Our result improves a previous result of Baier and Zhao in some aspects.
文摘Let(λ_f(n))_(n≥1)be the Hecke eigenvalues of either a holomorphic Hecke eigencuspform or a Hecke-Maass cusp form f.We prove that,for any fixedη>0,under the Ramanujan-Petersson conjecture for GL_(2)Maass forms,the Rankin-Selberg coefficients(λ_f(n)^(2))_(n≥1)admit a level of distributionθ=2/5+1/260-ηin arithmetic progressions.
文摘This lecture note is mainly about arithmetic progressions,different regularity lemmas and removal lemmas.We will be very brief most of the time,trying to avoid technical details,even definitions.For most technical details,we refer the reader to references.Apart from arithmetic progressions,we also discuss property testing and extremal graph theory.
文摘On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.
文摘Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
基金Supported by Shandong Provincial Key Research and Development Program(2023TZXD034)2024 National Undergraduate Innovation Training Program(202410061062).
文摘Yam(Dioscorea opposita)is an important economic crop,and the development of its the cultivation tecchnology is of great significance for increasing yield,improving quality,and reducing the occurrence of pests and diseases.With the progression of agricultural technology and changes in market demands,the cultivation tecchnology of yam is constantly innovating and improving.This paper reviewed recent research advances in yam cultivation tecchnology,covering aspects such as soil improvement,variety selection,technological innovations,green pest control,and harvesting and storage.The goal is to provide references for the sustainable development of the yam industry.
基金Supported by The Eye Hospital of Wenzhou Medical University(No.KYQD20220304)The Fifth Batch of Provincial Ten Thousand Personnel Program Outstanding Talents Funding(No.474092204)+1 种基金Innovative Talents and Teams(2024)-The Fifth Batch of Funding Funds for Scientific and Technological Innovation Leading Talents Under the Provincial Ten Thousand Personnel Program(No.4240924003G)The Key R&D Program of Zhejiang(No.2022C03112).
文摘AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.
文摘BACKGROUND Data comparing the outcomes of hepatocellular carcinoma(HCC)ablation by multibipolar radiofrequency ablation(mbp-RFA)and microwave ablation(MWA)are lacking.This study compares safety and efficacy of the two techniques in treatment-naive HCC.AIM To compare the risk of local tumor progression(LTP)according to the technique;secondary endpoints included technique efficacy rate at one-month,overall survival and major complication rate.METHODS A bi-institutional retrospective analysis of patients undergoing treatment-naive HCC ablation by either technique was performed.Inverse probability of treatment weighting was used to compare the two groups.Mixed effects multivariate Cox regression was applied to identify risk factors for LTP.RESULTS A total of 362 patients(mean age,66.1±6.2 years,308 men)were included,of which 242(323 tumors)treated by mbp-RFA and 120(168 tumors)by MWA.After a median follow-up of 27 months,cumulative LTP was 11.4%after mbp-RFA and 25.2%after MWA.Independent risk factors for LTP at multivariate analysis were MWA(hazard ratio=2.85,P<0.001)and tumor size(hazard ratio=1.08,P<0.001).Two-year LTP-free survival was higher after mbp-RFA than MWA regardless of size(<3 cm:96%vs 87.1%,P<0.01;≥3 cm:87.5%vs 74%,P=0.04).Technique efficacy rate was higher after mbp-RFA(94.1%vs 87.5%,P=0.01).No difference was observed in major complication rate(9.5%vs 7.5%,P=0.59),nor 5-year overall survival(63.6%vs 58.3%,P=0.33).CONCLUSION Mbp-RFA leads to better local tumor control of treatment-naïve HCC than MWA regardless of tumor size and has better primary efficacy,while maintaining a comparable safety profile.
文摘Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.
基金supported by Porsolt SAS,https://www.porsolt.com/.
文摘Objectives:The five-year survival rate for pancreatic cancer is notably low,posing a significant challenge to patient health.The primary treatments are radiotherapy and chemotherapy,sometimes combined with targeted therapy;however,their clinical benefits are limited.Therefore,developing new models to evaluate the therapeutic potential of novel molecules is essential.Fingolimod and Dimethyl Fumarate(DMF),currently used to treat multiple sclerosis,have recently been shown to have anti-cancer effects in several preclinical tumor models.This study aims to evaluate the therapeutic potential of Fingolimod and DMF in pancreatic cancer by investigating their respective in vitro cytotoxicity and in vivo antitumor effects.Methods:In this study,we evaluated for the first time these two drugs in pancreatic preclinical models in vitro using 3D spheroid tumor models and in vivo,which are compared to two standard-of-care consisting of Gemcitabine and Erlotinib.Results:In vitro,both Fingolimod and DMF induced cytotoxicity in spheroids from two pancreatic cell lines.Additionally,Fingolimod and DMF displayed anticancer effects in two subcutaneous xenograft models using PANC-1 and CFPAC-1 cells.Conclusions:Although the responses observed with Fingolimod and DMF were similar to those of Gemcitabine and Erlotinib,these findings indicate a potential emerging interest in Fingolimod and DMF for the treatment of pancreatic cancer.However,further work is still necessary to fully characterize how these drugs affect tumor progression.
基金Supported by Open Fund Project of the Engineering Technology Research Center of Characteristic Medicinal Plants of Fujian(PP202003).
文摘This paper provides a systematic review of the histochemical localization,content characteristics,and influencing factors of saponins in Pseudostellaria heterophylla based on an extensive literature survey.It provides an in-depth analysis and summary of the effects of biological factors,environmental conditions,agronomic practices,processing methods,and continuous cropping obstacles on the synthesis of P.heterophylla saponins,as well as their underlying mechanisms.Based on identified gaps in the current literature,future research directions and prospects are proposed.The findings of this review offer valuable insights for advancing the understanding of the saponin biosynthesis mechanisms in P.heterophylla and for enhancing its quality.
基金funded by Qinghai University Postgraduate Research and Practice Innovation Program of Funder,grant number 2025-GMKY-42.
文摘Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge perception,especially under complex dynamic blur.To address these challenges,we propose the Multi-Resolution Fusion Network(MRFNet),a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion.The network employs a three-stage design:(1)TransformerBlocks capture long-range dependencies and reconstruct coarse global structures;(2)Nonlinear Activation Free Blocks(NAFBlocks)enhance local detail representation and mid-level feature fusion;and(3)an optimized residual subnetwork based on gated feature modulation refines texture and edge details for high-fidelity restoration.Extensive experiments demonstrate that MRFNet achieves superior performance compared to state-of-the-art methods.On GoPro,it attains 32.52 dB Peak Signal-to-Noise Ratio(PSNR)and 0.071 Learned Perceptual Image Patch Similarity(LPIPS),outperforming MIMOWNet(32.50 dB,0.075).On HIDE,it achieves 30.25 dB PSNR and 0.945 Structural Similarity Index Measure(SSIM),representing gains of+0.26 dB and+0.015 SSIM over MIMO-UNet(29.99 dB,0.930).On RealBlur-J,it reaches 28.82 dB PSNR and 0.872 SSIM,surpassing MIMO-UNet by+1.19 dB and+0.035 SSIM(27.63 dB,0.837).These results validate the effectiveness of the proposed progressive residual fusion and hybrid attention mechanisms in balancing global context understanding and local detail recovery for blind image deblurring.
