To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situ...To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situation and international situation,and is an important part of the CPCCC‘s展开更多
The dual-carbon goal has become a major national strategy in China,and the structure of China's energy supply and demand will usher in a profound change.As a clean and efficient fossil energy source,natural gas sh...The dual-carbon goal has become a major national strategy in China,and the structure of China's energy supply and demand will usher in a profound change.As a clean and efficient fossil energy source,natural gas shoulders the important mission of transitioning the energy consumption structure from high-carbon to low-carbon.展开更多
In the long history of the Chinese nation,textile Craftsmanship shines like a brilliant pearl embedded in the treasure trove of traditional culture.It not only bears the wisdom of people's lives and aesthetic tast...In the long history of the Chinese nation,textile Craftsmanship shines like a brilliant pearl embedded in the treasure trove of traditional culture.It not only bears the wisdom of people's lives and aesthetic tastes but also vividly embodies the creativity and imagination of the Chinese nation.On the occasion of the first Spring Festival included in the Representative List of the Intangible Cultural Heritage of Humanity,we have the privilege to explore the remarkable textile ICH elements featured in the CCTV Spring Festival Gala.While enjoying the wonderful programs of the Gala,we can also feel the profound heritage and unique charm of traditional Chinese culture.展开更多
Editor's Note:Sixty years of nurturing winds and rains,sixty years of protound change.This year marks the 60th anniversary of the founding of the Xizang Autonomous Region.To mark this important historical mileston...Editor's Note:Sixty years of nurturing winds and rains,sixty years of protound change.This year marks the 60th anniversary of the founding of the Xizang Autonomous Region.To mark this important historical milestone,this column presents frontline reports and observations by our journalists.展开更多
At a February 2025 meeting,researchers presented their latest findings from a phase 1/2 clinical trial of a gene therapy,DB-OTO,developed by Regeneron Pharmaceuticals(Tarrytown,NY,USA)for a particular type of profound...At a February 2025 meeting,researchers presented their latest findings from a phase 1/2 clinical trial of a gene therapy,DB-OTO,developed by Regeneron Pharmaceuticals(Tarrytown,NY,USA)for a particular type of profound hearing loss in children.Nearly all the 12 participants,with no serious adverse events,experienced clinically meaningful and durable hearing improve-ments[1].A toddler born deaf,for example,could hear well enough after treatment to quack when asked,“What sound does a duck make?”[2].展开更多
The international order and global system are undergoing complex and profound changes nowadays.Unparalleled transformations in the world,the speed at which they happen,and the course of history are unfolding in unprec...The international order and global system are undergoing complex and profound changes nowadays.Unparalleled transformations in the world,the speed at which they happen,and the course of history are unfolding in unprecedented ways,ushering in a new period of turbulence and transition.Geopolitical and geo-economic competition among major powers is intensifying;global economic growth remains sluggish;crises and conflicts continue to emerge;and both regional and global peace and security are repeatedly challenged.展开更多
1.Introduction Driven by the current round of technological revolution and industrial transformation,and based on a consensus among countries around the world,the world’s energy landscape is undergoing profound adjus...1.Introduction Driven by the current round of technological revolution and industrial transformation,and based on a consensus among countries around the world,the world’s energy landscape is undergoing profound adjustments to promote a transition to clean,low-carbon energy in order to cope with global climate change.As a clean and carbon-free secondary energy source,hydrogen energy is an important component of the energy strategy in various countries.Fuel cell technology is also of great importance in directing the current global energy technology revolution.展开更多
Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia ind...Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 75.23±21.46 U/L; Cr 82.69±18.41μmol/L; LDH 944.67±834.32 U/L; TnT 0.336±0.076 ng/ml).Conclusion: Profound hypothermia-induced SADR is an effective method for inducing cardiac arrest. Our results indicate that inducing CA for 90 min(at 15℃) is safer than doing so for 120 min. Our results indicate that 120 min of CA at 15℃ is dangerous and can result in high mortality and severe neurological complications. Further experimentation is needed to determine whether 120 min of CA at temperatures lower than 15℃ can lead to safe recovery.展开更多
Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous ...Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous membranous structure and similar receptor cell ultrastructures, the cochlea and vestibule may be susceptible to the same harmful factors. Disorders of the inner ear may result in a variety of manifestations, including vertigo, spatial disorientation, blurred vision, impaired articulation, and hearing impairment. Considering the diversity of clinical symptoms associated with PSHL with otolithic dysfunction, it may be frequently misdiagnosed, and objective means of testing the function of otolithic organs should be recommended for hearing-impaired patients. Vestibular-evoked myogenic potentials (VEMPs) via air-conducted sound are of great importance for the diagnosis of otolithic function. Hearing devices such as cochlear implants are commonly accepted treatments for PSHL, and early identification and treatment of vestibular disorders may increase the success rate of cochlear implantation. Therefore, it is necessary to increase awareness of otolithic functional states in patients with PSHL.展开更多
The significant increase in the number of older adults in China,coupled with continuing industrialization and urbanization,has profound social and economic ramifications,including the evolution of major challenges to ...The significant increase in the number of older adults in China,coupled with continuing industrialization and urbanization,has profound social and economic ramifications,including the evolution of major challenges to public health,elder care services,policy-making,and the nation’s healthcare system.While the unprecedented changes in political and economic structures have obviously increased China’s productivity and revenues,what is less well understood is how they展开更多
BACKGROUND Dexmedetomidine(DMED)is frequently used as a sedative in several medical fields.The benefits of DMED include enhanced quality of regional anesthesia,prolonged analgesia,and postoperative opioid-sparing when...BACKGROUND Dexmedetomidine(DMED)is frequently used as a sedative in several medical fields.The benefits of DMED include enhanced quality of regional anesthesia,prolonged analgesia,and postoperative opioid-sparing when administered intravenously or perineurally in combination with regional anesthesia.Severe hemodynamic complications,such as profound bradycardia and hypotension,can occur after DMED administration in critically ill patients or overdosage;however,there are few reports of complications with DMED administration following brachial plexus block(BPB).CASE SUMMARY We present two cases of hemodynamic instability that occurred following the initial loading of DMED under supraclavicular BPB.A healthy 29-year-old man without any medical history showed profound bradycardia after receiving a loading dose of DMED 0.9μg/kg for 9 min.DMED administration was promptly stopped,and after receiving a second dose of atropine,the heart rate recovered.A 62-year-old woman with a history of cardiomyopathy became hypotensive abruptly,requiring the administration of inotrope and vasopressors after receiving a reduced loading dose of 0.5μg/kg for 10 min.Half of the recommended loading dose of DMED was administered due to the underlying heart dysfunction.Decrea-sed blood pressure was maintained despite the intravenous administration of ephedrine.With continuous infusion of dopamine and norepinephrine,the vital signs were maintained within normal ranges.Inotropic and vasopressor support was required for over 6 h after the initial loading dose of DMED.CONCLUSION DMED administration following BPB could trigger hemodynamic instability in patients with decreased cardiac function as well as in healthy individuals.展开更多
In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="...In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="EN-US" style="line-height: 97%;font-family:;" capt",serif;font-size:11pt;"="" pro="" minion="">been briefly recalled with crystal clear convincingness.</span></span></span>展开更多
In this short review paper, the significant and profound impacts of the Chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.
In this short review paper, the significant and profound impacts of the Pseudo Amino Acid Composition or PseAAC have been briefly presented with crystal clear convincingness.
China’s law-based modernization profoundly reflects the glorious history of the Communist Party of China’s continuous exploration of the development path of the rule of law.It has profoundly changed China,and is gre...China’s law-based modernization profoundly reflects the glorious history of the Communist Party of China’s continuous exploration of the development path of the rule of law.It has profoundly changed China,and is greatly affecting the course of world history.Xi Jinping,General Secretary of the Communist Party of China(CPC)Central Committee says that“The fundamental purpose of promoting the comprehen-sive rule of law is to safeguard the people’s rights and interests in accordance with the law.”展开更多
As a very common language phenomenon in English and Chinese culture, taboo exists in almost every aspects of daily life. Taboo is a relatively sensitive topic and it has distinctive national features and profound cult...As a very common language phenomenon in English and Chinese culture, taboo exists in almost every aspects of daily life. Taboo is a relatively sensitive topic and it has distinctive national features and profound cultural connotations. The comparative study of English and Chinese taboos is an important subject in intercultural communication, which is easy to be overlooked.The short knowledge of taboo is a great barrier in intercultural communication, therefore, making a comparative study of linguistic taboos becomes imperative.展开更多
文摘To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situation and international situation,and is an important part of the CPCCC‘s
基金2022 National Social Science Foundation Major Project:Research on the Path of High-quality Development of Natural Gas Industry Driven by Energy Revolution:Research on the Policy Guarantee System for High-quality Development of Natural Gas Industry of Sub-theme V(22&ZD105)2024 Chengdu Soft Science Research Project:Research on the Innovation Mechanism and Risk Prevention and Control of Chengdu's New Energy Industry under the Dual-Carbon Goal(2023-RK00-00174-ZF)2024 Sichuan Petroleum and Natural Gas Development Research Center.Annual Urban Gas Special Project:Mode Construction of High-Quality Transformation and Development of Gas Enterprises(2024SY024)。
文摘The dual-carbon goal has become a major national strategy in China,and the structure of China's energy supply and demand will usher in a profound change.As a clean and efficient fossil energy source,natural gas shoulders the important mission of transitioning the energy consumption structure from high-carbon to low-carbon.
文摘In the long history of the Chinese nation,textile Craftsmanship shines like a brilliant pearl embedded in the treasure trove of traditional culture.It not only bears the wisdom of people's lives and aesthetic tastes but also vividly embodies the creativity and imagination of the Chinese nation.On the occasion of the first Spring Festival included in the Representative List of the Intangible Cultural Heritage of Humanity,we have the privilege to explore the remarkable textile ICH elements featured in the CCTV Spring Festival Gala.While enjoying the wonderful programs of the Gala,we can also feel the profound heritage and unique charm of traditional Chinese culture.
文摘Editor's Note:Sixty years of nurturing winds and rains,sixty years of protound change.This year marks the 60th anniversary of the founding of the Xizang Autonomous Region.To mark this important historical milestone,this column presents frontline reports and observations by our journalists.
文摘At a February 2025 meeting,researchers presented their latest findings from a phase 1/2 clinical trial of a gene therapy,DB-OTO,developed by Regeneron Pharmaceuticals(Tarrytown,NY,USA)for a particular type of profound hearing loss in children.Nearly all the 12 participants,with no serious adverse events,experienced clinically meaningful and durable hearing improve-ments[1].A toddler born deaf,for example,could hear well enough after treatment to quack when asked,“What sound does a duck make?”[2].
文摘The international order and global system are undergoing complex and profound changes nowadays.Unparalleled transformations in the world,the speed at which they happen,and the course of history are unfolding in unprecedented ways,ushering in a new period of turbulence and transition.Geopolitical and geo-economic competition among major powers is intensifying;global economic growth remains sluggish;crises and conflicts continue to emerge;and both regional and global peace and security are repeatedly challenged.
文摘1.Introduction Driven by the current round of technological revolution and industrial transformation,and based on a consensus among countries around the world,the world’s energy landscape is undergoing profound adjustments to promote a transition to clean,low-carbon energy in order to cope with global climate change.As a clean and carbon-free secondary energy source,hydrogen energy is an important component of the energy strategy in various countries.Fuel cell technology is also of great importance in directing the current global energy technology revolution.
基金supported by the Major Project for Equipment Development of PLA in 2013(ASY135001)the National High Technology Research and Development Program of China(2015AA020312)
文摘Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 75.23±21.46 U/L; Cr 82.69±18.41μmol/L; LDH 944.67±834.32 U/L; TnT 0.336±0.076 ng/ml).Conclusion: Profound hypothermia-induced SADR is an effective method for inducing cardiac arrest. Our results indicate that inducing CA for 90 min(at 15℃) is safer than doing so for 120 min. Our results indicate that 120 min of CA at 15℃ is dangerous and can result in high mortality and severe neurological complications. Further experimentation is needed to determine whether 120 min of CA at temperatures lower than 15℃ can lead to safe recovery.
文摘Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous membranous structure and similar receptor cell ultrastructures, the cochlea and vestibule may be susceptible to the same harmful factors. Disorders of the inner ear may result in a variety of manifestations, including vertigo, spatial disorientation, blurred vision, impaired articulation, and hearing impairment. Considering the diversity of clinical symptoms associated with PSHL with otolithic dysfunction, it may be frequently misdiagnosed, and objective means of testing the function of otolithic organs should be recommended for hearing-impaired patients. Vestibular-evoked myogenic potentials (VEMPs) via air-conducted sound are of great importance for the diagnosis of otolithic function. Hearing devices such as cochlear implants are commonly accepted treatments for PSHL, and early identification and treatment of vestibular disorders may increase the success rate of cochlear implantation. Therefore, it is necessary to increase awareness of otolithic functional states in patients with PSHL.
文摘The significant increase in the number of older adults in China,coupled with continuing industrialization and urbanization,has profound social and economic ramifications,including the evolution of major challenges to public health,elder care services,policy-making,and the nation’s healthcare system.While the unprecedented changes in political and economic structures have obviously increased China’s productivity and revenues,what is less well understood is how they
基金Supported by the Fund of Biomedical Research Institute,Jeonbuk National University Hospital,Jeonju,Republic of Korea.
文摘BACKGROUND Dexmedetomidine(DMED)is frequently used as a sedative in several medical fields.The benefits of DMED include enhanced quality of regional anesthesia,prolonged analgesia,and postoperative opioid-sparing when administered intravenously or perineurally in combination with regional anesthesia.Severe hemodynamic complications,such as profound bradycardia and hypotension,can occur after DMED administration in critically ill patients or overdosage;however,there are few reports of complications with DMED administration following brachial plexus block(BPB).CASE SUMMARY We present two cases of hemodynamic instability that occurred following the initial loading of DMED under supraclavicular BPB.A healthy 29-year-old man without any medical history showed profound bradycardia after receiving a loading dose of DMED 0.9μg/kg for 9 min.DMED administration was promptly stopped,and after receiving a second dose of atropine,the heart rate recovered.A 62-year-old woman with a history of cardiomyopathy became hypotensive abruptly,requiring the administration of inotrope and vasopressors after receiving a reduced loading dose of 0.5μg/kg for 10 min.Half of the recommended loading dose of DMED was administered due to the underlying heart dysfunction.Decrea-sed blood pressure was maintained despite the intravenous administration of ephedrine.With continuous infusion of dopamine and norepinephrine,the vital signs were maintained within normal ranges.Inotropic and vasopressor support was required for over 6 h after the initial loading dose of DMED.CONCLUSION DMED administration following BPB could trigger hemodynamic instability in patients with decreased cardiac function as well as in healthy individuals.
文摘In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="EN-US" style="line-height: 97%;font-family:;" capt",serif;font-size:11pt;"="" pro="" minion="">been briefly recalled with crystal clear convincingness.</span></span></span>
文摘In this short review paper, the significant and profound impacts of the Chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.
文摘In this short review paper, the significant and profound impacts of the Pseudo Amino Acid Composition or PseAAC have been briefly presented with crystal clear convincingness.
文摘China’s law-based modernization profoundly reflects the glorious history of the Communist Party of China’s continuous exploration of the development path of the rule of law.It has profoundly changed China,and is greatly affecting the course of world history.Xi Jinping,General Secretary of the Communist Party of China(CPC)Central Committee says that“The fundamental purpose of promoting the comprehen-sive rule of law is to safeguard the people’s rights and interests in accordance with the law.”
文摘As a very common language phenomenon in English and Chinese culture, taboo exists in almost every aspects of daily life. Taboo is a relatively sensitive topic and it has distinctive national features and profound cultural connotations. The comparative study of English and Chinese taboos is an important subject in intercultural communication, which is easy to be overlooked.The short knowledge of taboo is a great barrier in intercultural communication, therefore, making a comparative study of linguistic taboos becomes imperative.
