Background:The aim of this study was to analyze the bi-directional causal relation-ship between lipid profile and characteristics related to muscle atrophy by using a bi-directional Mendelian randomization(MR)analysis...Background:The aim of this study was to analyze the bi-directional causal relation-ship between lipid profile and characteristics related to muscle atrophy by using a bi-directional Mendelian randomization(MR)analysis.Methods:The appendicular lean mass(ALM),whole body fat-free mass(WBFFM)and trunk fat-free mass(TFFM)were used as genome-wide association study(GWAS)data for evaluating muscle mass;the usual walking pace(UWP)and low grip strength(LGS)were used as GWAS data for evaluating muscle strength;and the triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL),low density lipo-protein cholesterol(LDL),apolipoprotein A-1(Apo A-1),and apolipoprotein B(Apo B)were used as GWAS data for evaluating lipid profile.For specific investigations,we mainly employed inverse variance weighting for causal estimation and MR-Egger for pleiotropy analysis.Results:MR results showed that the lipid profile predicted by genetic variants was negatively correlated with muscle mass,positively correlated with UWP,and was not causally correlated with LGS.On the other hand,the muscle mass predicted by genetic variants was negatively correlated with lipid profile,the UWP predicted by genetic variants was mainly positively correlated with lipid profile,while the LGS pre-dicted by genetic variants had no relevant causal relationship with lipid profile.Conclusions:Findings of this MR analysis suggest that hyperlipidemia may affect muscle mass and lead to muscle atrophy,but has no significant effect on muscle strength.On the other hand,increased muscle mass may reduce the incidence of dyslipidemia.展开更多
The study addressed a crucial public health concern of dyslipidemia and its management, with a focus on the Ignace DEEN National Hospital patients, filling a research gap in the Republic of Guinea. It contributed valu...The study addressed a crucial public health concern of dyslipidemia and its management, with a focus on the Ignace DEEN National Hospital patients, filling a research gap in the Republic of Guinea. It contributed valuable epidemiological data on dyslipidemia in the studied population, emphasizing gender, age, and socio-professional categories, which could inform tailored prevention and management strategies in improving the health care of dyslipidemia patients by proposing diets to help these patients better manage their disease and a food system for preventing dyslipidemia. The study focused on the lipid profile of patients seen at the cardiology department at the Ignace DEEN National Hospital Republic of Guinea (Conakry). This was a prospective, descriptive study lasting six (6) months from January 24 to July 23, 2021;aimed at determining the frequency of lipid abnormalities and pathologies related to the lipid profile. A total of 523 people were included in this study with a female predominance of 59.34% compared to 40.66% of males for a ratio of 1.5 in favor of women. The age groups of 45 - 54 and 55 - 65 were the most affected with respective frequencies of 45.42% and 30.03%. The most represented socio-professional category was that of housewives, i.e. 45.78%, followed by traders 18.68%. Our series was dominated by the married couple, i.e. 77.29%. Dyslipidemia constitutes a modifiable cardiovascular risk factor in patients seen in the cardiology department at the Ignace DEEN Hospital;its control must be strict through the use of hygienic and dietary rules and hypolipidemia medications.展开更多
As a disorder of lipid metabolism,hyperlipidemia(HLP)is characterized by elevated levels of lipids in the blood circulation.It is consistently related to the development of cardiovascular events and diseases associate...As a disorder of lipid metabolism,hyperlipidemia(HLP)is characterized by elevated levels of lipids in the blood circulation.It is consistently related to the development of cardiovascular events and diseases associated with metabolic syndrome.Alismatis Rhizoma decoction(ARD),a well-known traditional Chinese medicine prescription,has long been used for treating vertigo,which is a symptom experienced by HLP patients.In this study,we aimed to investigate the hyperlipidemic activity and the potential molecular mechanisms of ARD in HLP rats at the transcriptional level.RNA sequencing and transcriptome analysis were performed collaboratively,including analysis of differentially expressed genes(DEGs),GO functions,and KEGG pathway analysis.The results showed that 1981 DEGs(1370 upregulated and 611 downregulated)were identified in the HFD group compared with the CON group.Moreover,474 DEGs(350 upregulated and 124 downregulated)were detected in the ARD group compared with the HFD group.Furthermore,GO analysis revealed that DEGs were mainly involved in the following functions:developmental process,response to an external stimulus,ion transport,alcohol binding,and plasma membrane part.Pathway analysis suggested that these DEGs were significantly enriched in bile secretion,malaria,cell adhesion molecules,retinol metabolism,the sphingolipid signaling pathway,chemical carcinogenesis,and the T cell receptor signaling pathway.In conclusion,our study demonstrated that ARD alleviated the lipid metabolism disorder caused by HLP through multiple mechanisms,which provided vital scientific evidence for further pharmacological studies of ARD.展开更多
This study is to assess the potential factors that could affect the serum prostate-specific antigen （PSA） level in healthy younger men. We evaluated the associations of age, body mass index （BMI） and serum lipid p...This study is to assess the potential factors that could affect the serum prostate-specific antigen （PSA） level in healthy younger men. We evaluated the associations of age, body mass index （BMI） and serum lipid profile with serum PSA level in 6774 Chinese men （aged 20-49 years） who received a routine health examination. Eligible men were classified into 10-year age groups, BMI was categorized as underweight （〈18.5）, normal （18.5-22.9）, overweight （23.0-24.9）, obese （25.0-29,9） and very obese （〉30） according to the redefined World Health Organization （WHO） criteria for the Asia-Pacific region. PSA levels were compared among groups as well, In multiple linear regression analysis, PSA was positively correlated with age （P〈0.0001）. Negative correlations existed between PSA and BMI （P〈0.0001） and triglyceride level （P=0.01）. No relationship could be found between PSA and serum cholesterol （P=0.711） or high-density lipoprotein （HDL; P =0.665）. In addition, we found that serum PSA levels increased with age and decreased with BMI. Our study demonstrates that age, BMI and triglyceride levels influence the PSA level in men 〈50 years of age.展开更多
Objective To investigate the effects of physical activity （PA） on dyslipidemia and elevated resting heart rate （RHR） in a large-scale cross-sectional study in China. Methods We recruited community-based individual...Objective To investigate the effects of physical activity （PA） on dyslipidemia and elevated resting heart rate （RHR） in a large-scale cross-sectional study in China. Methods We recruited community-based individuals who were 40-60 years old using a cluster sampling method. The PA levels of the participants were classified as low, moderate, or high, using the International Physical Activity Questionnaire. Dyslipidemia was defined as the detection of abnormalities in lipid indicators, and 4 lipid parameters were evaluated using fasting blood samples. Multivariate logistic regression analyses were used to evaluate the associations of PA with dyslipidemia and RHR. Results A total of 10,321 participants （38.88% men） were included in this study. The percentages of individuals with high, moderate, and low PA levels were 46.5%, 43.9%, and 9.6%, respectively. In both men and women, high PA provided odds ratios of 0.88 [95% confidence interval （CI）： 0.83, 0.94] for dyslipidemia and 0.82 （95% CI： 0.73, 0.92） for elevated RHR, compared to participants with low PA. Conclusion Our data suggested that substantial health benefits （related to dyslipidemia and elevated RHR） occurred at higher intensity PA, with greater energy consumption, in middle-aged Chinese people, and particularly in men.展开更多
Schizophrenia is associated with a high preva- lence of cigarette-smoking and abnormal lipid profiles. The purpose of this study was to determine whether the profiles differ between schizophrenic smokers and non-smoke...Schizophrenia is associated with a high preva- lence of cigarette-smoking and abnormal lipid profiles. The purpose of this study was to determine whether the profiles differ between schizophrenic smokers and non-smokers and whether the lipid profiles are related to psychopathological symptoms. Serum lipid profiles were measured in 130 male inpatients with DSM-IV-defined schizophrenia： 104 smokers and 26 non-smokers. Symptoms were assessed using the Positive and Negative Syndrome Scale （PANSS）. Our results showed that positive PANSS symp- toms were fewer in smokers than in non-smokers, while the negative symptoms were fewer in those who smoked more cigarettes. Total protein and globulin levels were significantly lower in the smokers than in the non-smokers. However, there was no significant difference in total cholesterol, triglycerides, high-density lipoprotein choles terol （HDL-c）, low-density lipoprotein cholesterol, apolipoprotein A1, or apolipoprotein B between the smokers and non-smokers. However, the PANSS positive subscale had a significant negative correlation with the HDL-c levels （a protective factor） in the smokers but not in the non-smokers. Our findings suggest that schizophrenic patients who smoke have fewer psychotic symptoms, but contrary to expectation, smoking does not alter lipid profile levels.展开更多
Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) wa...Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.展开更多
Objective Previous studies on the association between lipid profiles and chronic kidney disease(CKD)have yielded inconsistent results and no defined thresholds for blood lipids.Methods A prospective cohort study inclu...Objective Previous studies on the association between lipid profiles and chronic kidney disease(CKD)have yielded inconsistent results and no defined thresholds for blood lipids.Methods A prospective cohort study including 32,351 subjects who completed baseline and follow-up surveys over 5 years was conducted.Restricted cubic splines and Cox models were used to examine the association between the lipid profiles and CKD.A regression discontinuity design was used to determine the cutoff value of lipid profiles that was significantly associated with increased the risk of CKD.Results Over a median follow-up time of 2.2(0.5,4.2)years,648(2.00%)subjects developed CKD.The lipid profiles that were significantly and linearly related to CKD included total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),TC/HDL-C,and TG/HDL-C,whereas lowdensity lipoprotein cholesterol(LDL-C)and LDL-C/HDL-C were nonlinearly correlated with CKD.TC,TG,TC/HDL-C,and TG/HDL-C showed an upward jump at the cutoff value,increasing the risk of CKD by 0.90%,1.50%,2.30%,and 1.60%,respectively,whereas HDL-C showed a downward jump at the cutoff value,reducing this risk by 1.0%.Female and participants with dyslipidemia had a higher risk of CKD,while the cutoff values for the different characteristics of the population were different.Conclusion There was a significant association between lipid profiles and CKD in a prospective cohort from Northwest China,while TG,TC/HDL-C,and TG/HDL-C showed a stronger risk association.The specific cutoff values of lipid profiles may provide a clinical reference for screening or diagnosing CKD risk.展开更多
Addition of sesame oil into layer diets has been proved to enrich the proportion of polyunsatu-rated fatty acids in animal’s products. In this study, the effects of different levels of sesame oil in the diets on the ...Addition of sesame oil into layer diets has been proved to enrich the proportion of polyunsatu-rated fatty acids in animal’s products. In this study, the effects of different levels of sesame oil in the diets on the performance, egg yolk and blood serum lipid profile of Isa Brown laying hens were investigated. A total of 96 layers were assigned into 4 groups to receive either 1 of 4 different diets contained 0.0%, 1.5%, 3.0% and 4.5% sesame oil, respectively. Sample of 12 eggs obtained from each groups were assessed for egg quality. The egg yolk fatty acid profile was determined with gas chromatography. Results revealed that the higher levels of sesame oil in the diet decreased egg production, egg weight, and egg yolk color except feed conversion ratio. In addition, supplementation of sesame oil increased the flow index of the eggs and the Haugh unite. The egg yolk lipid profile was not significantly different in the sesame oil fed groups, whereas, compare to control, it decreased the level of cholesterol. The blood serum lipid profile decreased in the sesame oil groups compare to control group. Meanwhile, monoacildigliserol also decreased in the sesame addition groups. In parallel with increasing levels of sesame oil, monounsaturated fatty acid (oleic acid) in the egg yolks significantly increased compared to the control (37.00%, 42.89%, 42.20% and 43.48%, respectively). It can be implied that sesame oil supplementation into the laying hens diet is necessary to produce monounsaturated fatty acid (MUFA) enriched eggs.展开更多
Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure...Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil;2) consume 20 ml/day grape seed oil;3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.展开更多
Poor fruit and vegetable consumption is one of the 10 major risk factors for mortality.There is a misconception regarding the consumption of dates among patients with diabetes.This manuscript assessed the effects of d...Poor fruit and vegetable consumption is one of the 10 major risk factors for mortality.There is a misconception regarding the consumption of dates among patients with diabetes.This manuscript assessed the effects of date consumption on fasting and postprandial blood glucose,glycated hemoglobin,total cholesterol,triglycerides,low-density lipoproteins,high-density lipoproteins,and microbial markers.Four literature databases were searched for relevant articles.Of the 595 studies retrieved,24 assessed the effects of dates on glycemic control and lipids.Overall,the evidence suggests that dates have a lowering effect on blood glucose.Dates reduce total cholesterol and triglyceride levels and increase high-density lipoprotein levels.Dates also promote the abundance of beneficial gut microbiota.Therefore,patients with diabetes and dyslipidemia can consume dates to reduce their blood glucose,cholesterol,and triglycerides.展开更多
In this study,the effects of sea buckthorn oil(SBO),fish oil(FO)and an enzymatically synthesized structured lipid(SL)on serum,short-chain fatty acids(SCFAs)and intestinal microbiota in Sprague-Dawley(SD)rats were inve...In this study,the effects of sea buckthorn oil(SBO),fish oil(FO)and an enzymatically synthesized structured lipid(SL)on serum,short-chain fatty acids(SCFAs)and intestinal microbiota in Sprague-Dawley(SD)rats were investigated.The results demonstrated that FO,SBO,and SL effectively reduced the levels of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in the serum of SD rats.SBO increased serum triglyceride levels,while FO elevated total cholesterol levels.Furthermore,all three dietary lipids decreased short-chain fatty acid production and enhanced intestinal microbiota diversity.FO increased the abundance of intestinal microbiota including Romboutsia,Lactobacillus,Escherichia-Shigella,and Lachnospiraceae_NK4A136_group.Conversely,all three dietary lipids reduced the abundance of Klebsiella and Blautia.These findings provide a foundation for understanding the functionality of SBO and FO as well as their potential application in synthesizing novel SLs to regulate intestinal microbiota.展开更多
<strong>Background:</strong><span><span><span style="font-family:;" "=""> Coronary heart disease (CHD) remains the major cause of </span></span></s...<strong>Background:</strong><span><span><span style="font-family:;" "=""> Coronary heart disease (CHD) remains the major cause of </span></span></span><span><span><span style="font-family:;" "="">mortality and morbidity in the entire world population despite therapeutic advances that control many risk factors. Lipid profile is regarded as an important factor in the development of coronary heart disease. There have been numerous studies confirming the association of hyperlipidemias with coronary heart disease in most of the Western as well as Asian countries of the <span>world. But we have very little data on the relation between CHD and lipid</span> profile.</span></span></span><span><span><span style="font-family:;" "=""> <b>Aim of the Study:</b> The aim of this study was to assess abnormal lipid levels and their association with coronary heart disease.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><b><span style="font-family:;" "="">Methods:</span></b></span></span><span><span><span style="font-family:;" "=""> This comparative observational study was conducted at the </span></span></span><span><span><span style="font-family:;" "="">Department of Cardiology in M. Abdur Rahim Medical College, Dinajpur, Bangladesh</span></span></span><span><span><span style="font-family:;" "=""> from January 2019 to December 2019. Properly written consent was taken from all the participants before starting the main part of the investigation. Obeying inclusion and exclusion criteria of the study, a total of 131 participants were finalized as the study population. Among them, the Case Group was formed with 90 pa<span>tients who had CHD, and with 41 healthy people, the Control Group was</span> <span>formed. All necessary data were collected, analyzed, and disseminated by</span> several programs of MS-Office and SPSS version 23. <b>Result:</b> The study was conducted with 90 case group participants and 41 control group participants. Among the case group, 78% were male and 22% were female. Among the male case group participants, 44.29% were from 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years of age, 35.71% were from 41</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">50 years of age and the rest 20% were above 60 years of age. On the other hand, among the female participants of Case Group, 45% were from 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years of age, 30% from 41</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">50 years of age, and 25% were over 60 years of age. Regression analysis between the male and the female showed the P-value of 0.242.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">Serum cholesterol concentration and HDL concentration were significant between the Case and Control groups in all age groups and the P-value was <0.0001 in every age group. Triglyceride concentration was significant between the Case and Control groups in 41</span></span></span><span><span><span style="font-family:;" "=""> - </span></span></span><span><span><span style="font-family:;" "="">50</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">and 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years age groups with a P-value of <0.0001. But in the >60 years age group</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> we did not find any significant correlation and there the P-value was 0.478. LDL concentration between the groups showed significant correlations between the Case and Control groups in 41</span></span></span><span><span><span style="font-family:;" "=""> - </span></span></span><span><span><span style="font-family:;" "="">50</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">and 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60-years’ age groups <span>where the P values were found, <0.0001 and 0.0002 respectively. But in </span>the >60 years’ age group</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> we did not find any significant correlation and there the P-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">value was 0.515. <b>Conclusion:</b> In this study, it was found that the total choles<span>terol, triglycerides, HDL cholesterol, and LDL cholesterol concentrations </span>were significantly higher in coronary heart disease (CHD) patients.</span></span></span>展开更多
Objective:To study the usefulness of traditional lipid profile levels in screening subjects who had developed chest pain due lo cardiac event as indicated by a positive troponin I test.Methods:In this retrospective st...Objective:To study the usefulness of traditional lipid profile levels in screening subjects who had developed chest pain due lo cardiac event as indicated by a positive troponin I test.Methods:In this retrospective study data of ihe 430 patients presented lo the emergency department with symptoms of cardiac ischemia who underwent both troponin and lipid profiles tests were compared with the lipid profiles of 165 normal healthy subjects(controls).The troponin was detected qualitatively when a specimen contains troponin I(cTnI)above the 99th percentile(TnI】0.5 ng/mL).The total cholesterol,high density lipoproteins cholesterol,very low density lipoproteins and Iriacvl glycerol levels were also analyzed and Ion densilv lipoprotein level was calculated using Friedewald’s formula.Results:Patients with chest pain and positive troponin test(with confirmed cardiac event)were found lo have significantly elevated levels of total cholesterol,triacyl glycerol levels,low density lipoprotein level and significantly reduced high densilv lipoproteins cholesterol levels when compared lo the patients who experienced only chesl pain(negative troponin)and healthy controls.Conclusions:Traditional lipid profile levels is still can be used in screening popiilalions lo identify the subjecis with high risk of developing cardiacevent in case if the laboratory set up has not troponin test facilities.展开更多
AIM: To evaluate the effect of an active fraction from Leptadenia reticulata leaves on serum glucose and lipid profile in normal and diabetic rats. METHOD: Diabetes was induced by streptozotocin in Wistar rats. Petrol...AIM: To evaluate the effect of an active fraction from Leptadenia reticulata leaves on serum glucose and lipid profile in normal and diabetic rats. METHOD: Diabetes was induced by streptozotocin in Wistar rats. Petroleum ether, ethyl acetate, and ethanol extracts of Leptadenia reticulata leaves were administered orally at a dose of 200 mg·kg-1, p.o. Metformin was used as standard anti diabetic drug(50 mg·kg-1, p.o). The extract showing higher antidiabetic activity was subjected to column chromatography and led to the isolation of an active fraction, which was given trivial name Lr-1. Lr-1(100 mg·kg-1, p.o.) was studied for its hypoglycemic and hypolipidemic potential. RESULTS: The ethanol extract was found to lower the FBG level significantly(P < 0.05) in diabetic rats. Lr-1 caused a significant(P < 0.05) reduction in FBG level, and additionally it caused reduction in cholesterol, triglyceride levels, and an improvement in the HDL level in diabetic rats. CONCLUSION: Reduction in the FBG, cholesterol, triglyceride levels, and an improvement in the HDL by Lr-1 indicates that Lr-1 has antidiabetic activity, along with cardioprotective potential, and provides a scientific rationale for the use as an antidiabetic agent.展开更多
AIM: To compare freeze-dried strawberry(FDS) beverage and strawberry-flavored drink effects on lipid profile and blood pressure in type 2 diabetic(T2D) patients.METHODS: In a randomized, double-blind, controlled trial...AIM: To compare freeze-dried strawberry(FDS) beverage and strawberry-flavored drink effects on lipid profile and blood pressure in type 2 diabetic(T2D) patients.METHODS: In a randomized, double-blind, controlled trial, 36 subjects with T2D(23 females; mean ± SE age: 51.57 ± 10 years) were randomly divided into two groups. Participants consumed two cups of either pure FDS beverage(each cup containing 25 g freeze-dried strawberry powder equivalent to one serving of fresh strawberries; intervention group) or an iso-caloric drinkwith strawberry flavoring(similar to the FDS drink in fiber content and color; placebo group) daily for 6 wk. Anthropometric measurements, 3 d, 24 h dietary recall, and fasting blood samples were collected at baseline and at weeks 6 intervention. After lying down and relaxing for approximately 10 min, each participant's blood pressure was recorded in triplicate with 5 min intervals; recordings were made at baseline and the trial end-point. Each participant's lipid profile was assessed before and after intervention.RESULTS: Assessment at the weeks 6 intervention showed a significant reduction from baseline in total cholesterol levels and total cholesterol to high-density lipoprotein cholesterol(HDL-C) ratio in the intervention group(179.01 ± 31.86 to 165.9 ± 32.4 mg/L; P = 0.00 and 3.9 ± 0.88 to 3.6 ± 0.082 mg/L; P = 0.00 respectively), but the change was not significantly different between the two groups(P = 0.07, P = 0.29 respectively). Systolic blood pressure levels were significantly reduced from baseline in both the FDS and placebo drink groups(129.95 ± 14.9 to 114.3 ± 27.5 mm Hg; P = 0.02 and 127.6 ± 15.6 to 122.9 ± 14.47 mm Hg; P = 0.00 respectively), but the reduction was not significantly different between the two groups. Diastolic blood pressure was significantly reduced post-intervention in the FDS drink group compared to placebo group(78.7 ± 7.2 vs 84.4 ± 5.8; P = 0.01), the reduction was also significant within the FDS drink group(84.2 ± 8.03 to 78.7 ± 7.2; P = 0.00). Triglycerides, HDL-C concentrations and anthropometric indices showed no significant differences between or within groups. CONCLUSION: Short-term FDS supplementation improved selected cardiovascular risk factors in subjects with T2 D. Long-term effects on other metabolic biomarkers need to be investigated in future trials.展开更多
Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia. Methods: The study comprised of 47 patients with metabolic endo...Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia. Methods: The study comprised of 47 patients with metabolic endotoxemia (the metabolic endotoxemia group) and 43 controls (the control group). Patients in the metabolic endotoxemia group were categorized further into three subgroups including the normal weight group (n=8), the overweight group (n=12) and the obese group (n=27). Height, weight, waist, and hip circumference were measured, and waist-hip ratio (WHR) and body mass index (BMI) were calculated. LBP was determined by ELISA and total cholesterol, triglycerides, high density lipoprotein by the respective enzymatic colorimetric methods. In addition, low density lipoprotein and very low density lipoprotein were determined by Friedewald's formula. Results: The mean waist circumference (WC), hip circumference (HC), BMI, total cholesterol, low density lipoprotein, and LBP of the metabolic endotoxemia group were significantly higher (P<0.05) than those of the control group. WHR, TG, high density lipoprotein and very low density lipoprotein of the metabolic endotoxemia group were not significantly different (P>0.05) from those of the control group. The mean WC, HC, WHR, and BMI of the obese group with metabolic endotoxemia were significantly higher (P<0.05) than those of the overweight group and the normal weight group with metabolic endotoxemia. Significant positive correlations were obtained between BMI and LBP (r=0.610, P=0.001), total cholesterol and LBP (r=0.385, P=0.007), TG and LBP (r=0.356, P=0.014) in patients with metabolic endotoxemia. Conclusions: Metabolic endotoxemia arising from increased circulating level of bacterial derive particles consequent to perturbation in the gut microbial community and the elevated ;serum level of LBP may precede the development of obesity, characterized by dyslipidemia, dysregulation of gut energy harvest, and metabolic energy imbalance.展开更多
Background High-grain(HG)diets affect lipid metabolism in the liver and mammary tissue of dairy cows,but its effects on muscle and adipose tissue have not been wide evaluated.Thus,the aim of this study is to clarify t...Background High-grain(HG)diets affect lipid metabolism in the liver and mammary tissue of dairy cows,but its effects on muscle and adipose tissue have not been wide evaluated.Thus,the aim of this study is to clarify this issue.Methods Twelve Holstein cows were randomly divided into two groups:conventional diet group(CON,n=6)and the HG diet group(n=6).On day 7 of week 4,rumen fluid was sampled to measure pH,milk was sampled to meas-ure components,and blood was sampled to measure biochemical parameters and fatty acid composition.After the experiment,cows were slaughtered to collect muscle and adipose tissue for fatty acid composition and transcriptome analysis.Results HG feeding decreased the ruminal pH,milk’s fat content and long-chain fatty acid proportion(P<0.05)and increased the proportion of short-and medium-chain fatty acids in the milk(P<0.05)as compared with CON diets.The concentrations of blood cholesterol,low-density lipoprotein,and polyunsaturated fatty acids in the HG cows were lower than those in CON cows(P<0.05).In muscle tissue,HG feeding tended to increase the triacylglycerol(TG)concentration(P<0.10).Transcriptome analysis revealed changes in the biosynthesis of the unsaturated fatty acids pathway,the regulation of lipolysis in the adipocytes pathway,and the PPAR signalling pathway.In adipose tissue,HG feeding increased the concentration of TG and decreased the concentration of C18:1 cis9(P<0.05).At the transcrip-tome level,the fatty acid biosynthesis pathway,linoleic acid metabolism pathway,and PPAR signalling pathway were activated.Conclusion HG feeding leads to subacute rumen acidosis and a decreased milk fat content.The fatty acid profiles in the milk and plasma of dairy cows were changed by HG feeding.In muscle and adipose tissue,HG feeding increased TG concentration and up-regulated the expression of genes related to adipogenesis,while down-regulated the expression of genes related to lipid transport.These results complement our knowledge of the fatty acid composi-tion of muscle and adipose tissue in dairy cows and expand our understanding of the mechanisms by which HG diets affect lipid metabolism in muscle and adipose tissue.展开更多
Diabetes is a major health global problem that has reached alarming levels. The present study aims for studying the effect of date palm pollen (<i><span style="font-family:Verdana;">Phoenix dacty...Diabetes is a major health global problem that has reached alarming levels. The present study aims for studying the effect of date palm pollen (<i><span style="font-family:Verdana;">Phoenix dactylifera L</span></i><span style="font-family:Verdana;">.) El-Hayani cultivar on serum glucose and lipids profile in induced diabetic male albino rats. Palm pollen chemically analyzed besides chemical constituents, mineral contents, polyphenols </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> flavonoids. Male Albino rats (36</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">rats </span><span style="font-family:Verdana;">weight 170</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">190</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">gm) were divided </span><span style="font-family:Verdana;">in</span><span style="font-family:Verdana;">to</span><span style="font-family:Verdana;"> 6 groups. 1</span><span style="font-family:Verdana;">: </span><span style="font-family:Verdana;">Normal control (</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">), 2</span><span style="font-family:Verdana;">:</span><span style="font-family:Verdana;"> Alloxanized diabetes control (+) (150</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mg/Kg rat body weight). Diabetic groups 3 and 4 had 0.5%,</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">1.0% date palm pollen, respectively, also diabetic </span><span style="font-family:Verdana;">group</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> 5 and 6 had 100 ppm, 200 ppm date palm pollen extract, respectively. At the end of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">experiment</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (4 weeks) rats were fasted overnight and anesthetized and blood samples were taken for analysis of serum glucose, lipids profile </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> renal-hepatic function parameters, relative organ weight data obtained are </span><span style="font-family:Verdana;">statistically</span><span style="font-family:Verdana;"> analysis. Results showed that the major polyphenolic components were that e-vanillic acid (16.33 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), pyrogallol (15.02 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), epicatechin (11.04 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), catechin (10.96 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g). </span><span style="font-family:Verdana;">While,</span><span style="font-family:Verdana;"> date palm pollen was rich in hesperidin (8.84 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), Kaempferol 3</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">2 p-coumaroyl glucose (6.92 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g), </span><span style="font-family:Verdana;">hesperitin</span><span style="font-family:Verdana;"> (5.10 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), rutin (3.11mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g) as flavonoids components. Date palm pollen has </span><span style="font-family:Verdana;">high</span><span style="font-family:Verdana;"> content of protein, calcium </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> iron (30.87 g/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g, 510.82 </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> 236.50 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g), respectively. Also, serum glucose decreased significantly in diabetic groups (3, 4, 5 </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> 6, respectively) (179.47, 137.80, 156.77, 145.47 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">mL, respectively). Lipids profile, renal and liver functions were improved </span><span style="font-family:Verdana;">significant</span></span><span style="font-family:Verdana;">ly</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (P < 0.05) in diabetic groups </span><span style="font-family:Verdana;">which had</span><span style="font-family:Verdana;"> date palm pollen or its extracts.</span></span><span> </span><span style="font-family:Verdana;">It is concluded that the dried date palm pollen 1% in the diet and 200 ppm extract are more effective compared with controlling diabetes mellitus, also improve renal and liver functions. Diabetics are advised to eat date palm pollen</span><span style="font-family:Verdana;"> and</span><span style="font-family:Verdana;"> are considered treatment foods for Diabetes Mellitus.</span>展开更多
<div style="text-align:justify;"> <strong>Background:</strong> By the dawn of this modern era of science, the prime challenge of physician is cardiovascular disease (CVD).<span "=&q...<div style="text-align:justify;"> <strong>Background:</strong> By the dawn of this modern era of science, the prime challenge of physician is cardiovascular disease (CVD).<span "=""> </span><span "="">The most important modifiable risk factors of CVDs are unhealthy diet, physical inactivity and tobacco use. The effects of unhealthy diet and physical inactivity include abnormal blood lipid, obesity and hypertension. We tried to evaluate and correlate the pattern of lipid profile in obese and non-obese hypertensive patients. <b>Objectives:</b> This study was conducted at medicine department of Cumilla Medical College Hospital. The principal aim was to evaluate the lipid profile in obese and non-obese adult hypertensive patients. <b>Methodology:</b> During this cross sectional analytical study, </span>a total of<span "=""> </span>100 adult hypertensive patients were taken by purposive sampling. Among them 50<span "=""> </span>(group 1) patients were taken those were obese and 50<span "=""> </span>(group 2) patients taken those were non-obese according to BMI measurement on operational definition. Diagnosis of hypertension would be established with the help of ambulatory BP measurements two occasions few minutes apart. The staging of hypertension was done according to JNC7 Criteria. Morning blood samples were taken after 8<span "=""> </span>-<span "=""> </span>12 hours of fasting and lipid profiles were done on authentic laboratories. The laboratory values were interpreted according to the operational definition of dyslipidaemia. The ethical research and review committee approved the study protocol and signed informed consent was obtained from the participants. The statistics was analyzed using the IBM SPSS software of version 19.0.<span "=""> </span><span "="">Statistical significance was set at p < 0.05. <b>Results:</b> Among the two groups, there were 56 (56%) male</span>s and 44 (44%) females. The mean age of group 1 (46.10 ± 11.09) was compared to that of group 2 (45.5 ± 10.6). Lipid profile abnormalities were significantly higher in the stage 2 hypertension<span "=""> </span>(59.62%) and stage 3 hypertension<span "=""> </span>(66.66%), higher in class 2 obese<span "=""> </span>(100%) and class 3 obese subjects<span "=""> </span>(100%),<span "=""> </span>female hypertensive patients had significantly higher BMI than their male counterparts<span "=""> </span>(27.24 ± 3.63<span "=""> </span><span "="">kg/m<sup>2</sup> versus 29.29 ± 3.99</span><span "=""> </span><span "="">kg/m<sup>2</sup>),</span><span "=""> </span>lipid profiles were higher in the female than male hypertensive patients (63.33% vs 55.35%) but only TC was statistically significant (4.45 ± 1.19<span "=""> </span>mmol/l versus 4.86 ± 1.29<span "=""> </span>mmol/l, p < 0.05). Those who were obese had significant high TG (p < 0.001), high TC (p < 0.001) and high LDL-C (p < 0.001). 38<span "=""> </span>(76%) of the obese hypertensive patients had dyslipidaemia whereas 21<span "=""> </span>(42%) of non-obese hypertensive patients had dyslipidaemia. In multivariate regression, TG was significantly and directly associated with BMI of subjects. Dyslipidaemia was more prevalent in the age group 30<span "=""> </span>-<span "=""> </span>59 of adult hypertensive patients. It showed that obese hypertensive patients had significantly higher SBP<span "=""> </span>(p < 0.001), DBP<span "=""> </span>(p < 0.001) than non-obese subjects. The mean TC (4.83 ± 0.95<span "=""> </span>mmol/l versus 4.15 ± 0.57<span "=""> </span>mmol/l, t = -9.70, p < 0.001), TG (2.64 ± 0.67<span "=""> </span>mmol/l versus 2.10 ± 0.45<span "=""> </span>mmol/l, t = -5.37, p < 0.001) and LDL-C (3.00 ± 0.82<span "=""> </span>mmol/l versus 2.44 ± 0.53<span "=""> </span>mmol/l, t = -9.11, p < 0.001) were also significantly higher among the hypertensive obese subjects. The mean HDL-C was however comparable in the two groups (1.25 ± 0.27<span "=""> </span>mmol/l versus 1.24 ± 0.57<span "=""> </span>mmol/l, t = -0.25, p = 0.08)... </div>展开更多
基金Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2021A1515220030Hunan Provincial Clinical Medical Technology Innovation Guiding Project,Grant/Award Number:2020SK53307+2 种基金Hunan Provincial Health Commission,Grant/Award Number:20201902Natural Science Foundation of Hunan Province,Grant/Award Number:2020JJ8043Project of Hunan Provincial Health,Grant/Award Number:c2019133。
文摘Background:The aim of this study was to analyze the bi-directional causal relation-ship between lipid profile and characteristics related to muscle atrophy by using a bi-directional Mendelian randomization(MR)analysis.Methods:The appendicular lean mass(ALM),whole body fat-free mass(WBFFM)and trunk fat-free mass(TFFM)were used as genome-wide association study(GWAS)data for evaluating muscle mass;the usual walking pace(UWP)and low grip strength(LGS)were used as GWAS data for evaluating muscle strength;and the triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL),low density lipo-protein cholesterol(LDL),apolipoprotein A-1(Apo A-1),and apolipoprotein B(Apo B)were used as GWAS data for evaluating lipid profile.For specific investigations,we mainly employed inverse variance weighting for causal estimation and MR-Egger for pleiotropy analysis.Results:MR results showed that the lipid profile predicted by genetic variants was negatively correlated with muscle mass,positively correlated with UWP,and was not causally correlated with LGS.On the other hand,the muscle mass predicted by genetic variants was negatively correlated with lipid profile,the UWP predicted by genetic variants was mainly positively correlated with lipid profile,while the LGS pre-dicted by genetic variants had no relevant causal relationship with lipid profile.Conclusions:Findings of this MR analysis suggest that hyperlipidemia may affect muscle mass and lead to muscle atrophy,but has no significant effect on muscle strength.On the other hand,increased muscle mass may reduce the incidence of dyslipidemia.
文摘The study addressed a crucial public health concern of dyslipidemia and its management, with a focus on the Ignace DEEN National Hospital patients, filling a research gap in the Republic of Guinea. It contributed valuable epidemiological data on dyslipidemia in the studied population, emphasizing gender, age, and socio-professional categories, which could inform tailored prevention and management strategies in improving the health care of dyslipidemia patients by proposing diets to help these patients better manage their disease and a food system for preventing dyslipidemia. The study focused on the lipid profile of patients seen at the cardiology department at the Ignace DEEN National Hospital Republic of Guinea (Conakry). This was a prospective, descriptive study lasting six (6) months from January 24 to July 23, 2021;aimed at determining the frequency of lipid abnormalities and pathologies related to the lipid profile. A total of 523 people were included in this study with a female predominance of 59.34% compared to 40.66% of males for a ratio of 1.5 in favor of women. The age groups of 45 - 54 and 55 - 65 were the most affected with respective frequencies of 45.42% and 30.03%. The most represented socio-professional category was that of housewives, i.e. 45.78%, followed by traders 18.68%. Our series was dominated by the married couple, i.e. 77.29%. Dyslipidemia constitutes a modifiable cardiovascular risk factor in patients seen in the cardiology department at the Ignace DEEN Hospital;its control must be strict through the use of hygienic and dietary rules and hypolipidemia medications.
基金The Basic Research Project of Fujian Provincial Public Welfare Research Institute(Grant No.2018R1031-3)Medical Innovation Project of Fujian Provincial Health Commission(Grant No.2018-CX-15)+1 种基金Basic Research Project of Fujian Provincial Public Welfare Research Institute,China(Grant No.2019R1011-5)High-Level Hospital grants(Grant No.2017GL-001)from Fujian Provincial Hospita,Fujian Province,China。
文摘As a disorder of lipid metabolism,hyperlipidemia(HLP)is characterized by elevated levels of lipids in the blood circulation.It is consistently related to the development of cardiovascular events and diseases associated with metabolic syndrome.Alismatis Rhizoma decoction(ARD),a well-known traditional Chinese medicine prescription,has long been used for treating vertigo,which is a symptom experienced by HLP patients.In this study,we aimed to investigate the hyperlipidemic activity and the potential molecular mechanisms of ARD in HLP rats at the transcriptional level.RNA sequencing and transcriptome analysis were performed collaboratively,including analysis of differentially expressed genes(DEGs),GO functions,and KEGG pathway analysis.The results showed that 1981 DEGs(1370 upregulated and 611 downregulated)were identified in the HFD group compared with the CON group.Moreover,474 DEGs(350 upregulated and 124 downregulated)were detected in the ARD group compared with the HFD group.Furthermore,GO analysis revealed that DEGs were mainly involved in the following functions:developmental process,response to an external stimulus,ion transport,alcohol binding,and plasma membrane part.Pathway analysis suggested that these DEGs were significantly enriched in bile secretion,malaria,cell adhesion molecules,retinol metabolism,the sphingolipid signaling pathway,chemical carcinogenesis,and the T cell receptor signaling pathway.In conclusion,our study demonstrated that ARD alleviated the lipid metabolism disorder caused by HLP through multiple mechanisms,which provided vital scientific evidence for further pharmacological studies of ARD.
文摘This study is to assess the potential factors that could affect the serum prostate-specific antigen （PSA） level in healthy younger men. We evaluated the associations of age, body mass index （BMI） and serum lipid profile with serum PSA level in 6774 Chinese men （aged 20-49 years） who received a routine health examination. Eligible men were classified into 10-year age groups, BMI was categorized as underweight （〈18.5）, normal （18.5-22.9）, overweight （23.0-24.9）, obese （25.0-29,9） and very obese （〉30） according to the redefined World Health Organization （WHO） criteria for the Asia-Pacific region. PSA levels were compared among groups as well, In multiple linear regression analysis, PSA was positively correlated with age （P〈0.0001）. Negative correlations existed between PSA and BMI （P〈0.0001） and triglyceride level （P=0.01）. No relationship could be found between PSA and serum cholesterol （P=0.711） or high-density lipoprotein （HDL; P =0.665）. In addition, we found that serum PSA levels increased with age and decreased with BMI. Our study demonstrates that age, BMI and triglyceride levels influence the PSA level in men 〈50 years of age.
文摘Objective To investigate the effects of physical activity （PA） on dyslipidemia and elevated resting heart rate （RHR） in a large-scale cross-sectional study in China. Methods We recruited community-based individuals who were 40-60 years old using a cluster sampling method. The PA levels of the participants were classified as low, moderate, or high, using the International Physical Activity Questionnaire. Dyslipidemia was defined as the detection of abnormalities in lipid indicators, and 4 lipid parameters were evaluated using fasting blood samples. Multivariate logistic regression analyses were used to evaluate the associations of PA with dyslipidemia and RHR. Results A total of 10,321 participants （38.88% men） were included in this study. The percentages of individuals with high, moderate, and low PA levels were 46.5%, 43.9%, and 9.6%, respectively. In both men and women, high PA provided odds ratios of 0.88 [95% confidence interval （CI）： 0.83, 0.94] for dyslipidemia and 0.82 （95% CI： 0.73, 0.92） for elevated RHR, compared to participants with low PA. Conclusion Our data suggested that substantial health benefits （related to dyslipidemia and elevated RHR） occurred at higher intensity PA, with greater energy consumption, in middle-aged Chinese people, and particularly in men.
基金supported by the National Natural Science Foundation of China(81371477)the Beijing Municipal Natural Science Foundation(7132063 and 7072035)a National Alliance for Research on Schizophrenia and Depression Independent Investigator Grant(20314)
文摘Schizophrenia is associated with a high preva- lence of cigarette-smoking and abnormal lipid profiles. The purpose of this study was to determine whether the profiles differ between schizophrenic smokers and non-smokers and whether the lipid profiles are related to psychopathological symptoms. Serum lipid profiles were measured in 130 male inpatients with DSM-IV-defined schizophrenia： 104 smokers and 26 non-smokers. Symptoms were assessed using the Positive and Negative Syndrome Scale （PANSS）. Our results showed that positive PANSS symp- toms were fewer in smokers than in non-smokers, while the negative symptoms were fewer in those who smoked more cigarettes. Total protein and globulin levels were significantly lower in the smokers than in the non-smokers. However, there was no significant difference in total cholesterol, triglycerides, high-density lipoprotein choles terol （HDL-c）, low-density lipoprotein cholesterol, apolipoprotein A1, or apolipoprotein B between the smokers and non-smokers. However, the PANSS positive subscale had a significant negative correlation with the HDL-c levels （a protective factor） in the smokers but not in the non-smokers. Our findings suggest that schizophrenic patients who smoke have fewer psychotic symptoms, but contrary to expectation, smoking does not alter lipid profile levels.
基金supported by the Tokushima prefectural government
文摘Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.
基金supported by the Municipal Science and Technology Program of Wuwei City,China(WW2202RPZ037)the Fundamental Research Funds for the Central Universities in China(Grant No.lzujbky-2018-69).
文摘Objective Previous studies on the association between lipid profiles and chronic kidney disease(CKD)have yielded inconsistent results and no defined thresholds for blood lipids.Methods A prospective cohort study including 32,351 subjects who completed baseline and follow-up surveys over 5 years was conducted.Restricted cubic splines and Cox models were used to examine the association between the lipid profiles and CKD.A regression discontinuity design was used to determine the cutoff value of lipid profiles that was significantly associated with increased the risk of CKD.Results Over a median follow-up time of 2.2(0.5,4.2)years,648(2.00%)subjects developed CKD.The lipid profiles that were significantly and linearly related to CKD included total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),TC/HDL-C,and TG/HDL-C,whereas lowdensity lipoprotein cholesterol(LDL-C)and LDL-C/HDL-C were nonlinearly correlated with CKD.TC,TG,TC/HDL-C,and TG/HDL-C showed an upward jump at the cutoff value,increasing the risk of CKD by 0.90%,1.50%,2.30%,and 1.60%,respectively,whereas HDL-C showed a downward jump at the cutoff value,reducing this risk by 1.0%.Female and participants with dyslipidemia had a higher risk of CKD,while the cutoff values for the different characteristics of the population were different.Conclusion There was a significant association between lipid profiles and CKD in a prospective cohort from Northwest China,while TG,TC/HDL-C,and TG/HDL-C showed a stronger risk association.The specific cutoff values of lipid profiles may provide a clinical reference for screening or diagnosing CKD risk.
文摘Addition of sesame oil into layer diets has been proved to enrich the proportion of polyunsatu-rated fatty acids in animal’s products. In this study, the effects of different levels of sesame oil in the diets on the performance, egg yolk and blood serum lipid profile of Isa Brown laying hens were investigated. A total of 96 layers were assigned into 4 groups to receive either 1 of 4 different diets contained 0.0%, 1.5%, 3.0% and 4.5% sesame oil, respectively. Sample of 12 eggs obtained from each groups were assessed for egg quality. The egg yolk fatty acid profile was determined with gas chromatography. Results revealed that the higher levels of sesame oil in the diet decreased egg production, egg weight, and egg yolk color except feed conversion ratio. In addition, supplementation of sesame oil increased the flow index of the eggs and the Haugh unite. The egg yolk lipid profile was not significantly different in the sesame oil fed groups, whereas, compare to control, it decreased the level of cholesterol. The blood serum lipid profile decreased in the sesame oil groups compare to control group. Meanwhile, monoacildigliserol also decreased in the sesame addition groups. In parallel with increasing levels of sesame oil, monounsaturated fatty acid (oleic acid) in the egg yolks significantly increased compared to the control (37.00%, 42.89%, 42.20% and 43.48%, respectively). It can be implied that sesame oil supplementation into the laying hens diet is necessary to produce monounsaturated fatty acid (MUFA) enriched eggs.
文摘Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil;2) consume 20 ml/day grape seed oil;3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.
文摘Poor fruit and vegetable consumption is one of the 10 major risk factors for mortality.There is a misconception regarding the consumption of dates among patients with diabetes.This manuscript assessed the effects of date consumption on fasting and postprandial blood glucose,glycated hemoglobin,total cholesterol,triglycerides,low-density lipoproteins,high-density lipoproteins,and microbial markers.Four literature databases were searched for relevant articles.Of the 595 studies retrieved,24 assessed the effects of dates on glycemic control and lipids.Overall,the evidence suggests that dates have a lowering effect on blood glucose.Dates reduce total cholesterol and triglyceride levels and increase high-density lipoprotein levels.Dates also promote the abundance of beneficial gut microbiota.Therefore,patients with diabetes and dyslipidemia can consume dates to reduce their blood glucose,cholesterol,and triglycerides.
基金supported by the Key Research and Development Project of Xinjiang Uygur Autonomous Region(2022B02005-2-3)the Natural Science Foundation of Hubei Province(2022CFB458)+2 种基金the Key Research and Development Project of Xinjiang Uygur Autonomous Region(2022B02018-3)the Key Research and Development Project of Xinjiang Uygur Autonomous Region(2022B02045-3)the Innovation Project of Xinjiang Uygur Autonomous Region University Students(S202310758031).
文摘In this study,the effects of sea buckthorn oil(SBO),fish oil(FO)and an enzymatically synthesized structured lipid(SL)on serum,short-chain fatty acids(SCFAs)and intestinal microbiota in Sprague-Dawley(SD)rats were investigated.The results demonstrated that FO,SBO,and SL effectively reduced the levels of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in the serum of SD rats.SBO increased serum triglyceride levels,while FO elevated total cholesterol levels.Furthermore,all three dietary lipids decreased short-chain fatty acid production and enhanced intestinal microbiota diversity.FO increased the abundance of intestinal microbiota including Romboutsia,Lactobacillus,Escherichia-Shigella,and Lachnospiraceae_NK4A136_group.Conversely,all three dietary lipids reduced the abundance of Klebsiella and Blautia.These findings provide a foundation for understanding the functionality of SBO and FO as well as their potential application in synthesizing novel SLs to regulate intestinal microbiota.
文摘<strong>Background:</strong><span><span><span style="font-family:;" "=""> Coronary heart disease (CHD) remains the major cause of </span></span></span><span><span><span style="font-family:;" "="">mortality and morbidity in the entire world population despite therapeutic advances that control many risk factors. Lipid profile is regarded as an important factor in the development of coronary heart disease. There have been numerous studies confirming the association of hyperlipidemias with coronary heart disease in most of the Western as well as Asian countries of the <span>world. But we have very little data on the relation between CHD and lipid</span> profile.</span></span></span><span><span><span style="font-family:;" "=""> <b>Aim of the Study:</b> The aim of this study was to assess abnormal lipid levels and their association with coronary heart disease.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><b><span style="font-family:;" "="">Methods:</span></b></span></span><span><span><span style="font-family:;" "=""> This comparative observational study was conducted at the </span></span></span><span><span><span style="font-family:;" "="">Department of Cardiology in M. Abdur Rahim Medical College, Dinajpur, Bangladesh</span></span></span><span><span><span style="font-family:;" "=""> from January 2019 to December 2019. Properly written consent was taken from all the participants before starting the main part of the investigation. Obeying inclusion and exclusion criteria of the study, a total of 131 participants were finalized as the study population. Among them, the Case Group was formed with 90 pa<span>tients who had CHD, and with 41 healthy people, the Control Group was</span> <span>formed. All necessary data were collected, analyzed, and disseminated by</span> several programs of MS-Office and SPSS version 23. <b>Result:</b> The study was conducted with 90 case group participants and 41 control group participants. Among the case group, 78% were male and 22% were female. Among the male case group participants, 44.29% were from 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years of age, 35.71% were from 41</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">50 years of age and the rest 20% were above 60 years of age. On the other hand, among the female participants of Case Group, 45% were from 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years of age, 30% from 41</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">50 years of age, and 25% were over 60 years of age. Regression analysis between the male and the female showed the P-value of 0.242.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">Serum cholesterol concentration and HDL concentration were significant between the Case and Control groups in all age groups and the P-value was <0.0001 in every age group. Triglyceride concentration was significant between the Case and Control groups in 41</span></span></span><span><span><span style="font-family:;" "=""> - </span></span></span><span><span><span style="font-family:;" "="">50</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">and 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60 years age groups with a P-value of <0.0001. But in the >60 years age group</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> we did not find any significant correlation and there the P-value was 0.478. LDL concentration between the groups showed significant correlations between the Case and Control groups in 41</span></span></span><span><span><span style="font-family:;" "=""> - </span></span></span><span><span><span style="font-family:;" "="">50</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">and 51</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">60-years’ age groups <span>where the P values were found, <0.0001 and 0.0002 respectively. But in </span>the >60 years’ age group</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> we did not find any significant correlation and there the P-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">value was 0.515. <b>Conclusion:</b> In this study, it was found that the total choles<span>terol, triglycerides, HDL cholesterol, and LDL cholesterol concentrations </span>were significantly higher in coronary heart disease (CHD) patients.</span></span></span>
基金Supported by Confederation of Epidemiological Associations registered under Govt of Kerala.Grant No.30-955/2012 CEA
文摘Objective:To study the usefulness of traditional lipid profile levels in screening subjects who had developed chest pain due lo cardiac event as indicated by a positive troponin I test.Methods:In this retrospective study data of ihe 430 patients presented lo the emergency department with symptoms of cardiac ischemia who underwent both troponin and lipid profiles tests were compared with the lipid profiles of 165 normal healthy subjects(controls).The troponin was detected qualitatively when a specimen contains troponin I(cTnI)above the 99th percentile(TnI】0.5 ng/mL).The total cholesterol,high density lipoproteins cholesterol,very low density lipoproteins and Iriacvl glycerol levels were also analyzed and Ion densilv lipoprotein level was calculated using Friedewald’s formula.Results:Patients with chest pain and positive troponin test(with confirmed cardiac event)were found lo have significantly elevated levels of total cholesterol,triacyl glycerol levels,low density lipoprotein level and significantly reduced high densilv lipoproteins cholesterol levels when compared lo the patients who experienced only chesl pain(negative troponin)and healthy controls.Conclusions:Traditional lipid profile levels is still can be used in screening popiilalions lo identify the subjecis with high risk of developing cardiacevent in case if the laboratory set up has not troponin test facilities.
基金supported by the University Grants Commission,New Delhi,India.UGC-BSR Fellowship-F.4-1/2006(BSR)/7-269/20210
文摘AIM: To evaluate the effect of an active fraction from Leptadenia reticulata leaves on serum glucose and lipid profile in normal and diabetic rats. METHOD: Diabetes was induced by streptozotocin in Wistar rats. Petroleum ether, ethyl acetate, and ethanol extracts of Leptadenia reticulata leaves were administered orally at a dose of 200 mg·kg-1, p.o. Metformin was used as standard anti diabetic drug(50 mg·kg-1, p.o). The extract showing higher antidiabetic activity was subjected to column chromatography and led to the isolation of an active fraction, which was given trivial name Lr-1. Lr-1(100 mg·kg-1, p.o.) was studied for its hypoglycemic and hypolipidemic potential. RESULTS: The ethanol extract was found to lower the FBG level significantly(P < 0.05) in diabetic rats. Lr-1 caused a significant(P < 0.05) reduction in FBG level, and additionally it caused reduction in cholesterol, triglyceride levels, and an improvement in the HDL level in diabetic rats. CONCLUSION: Reduction in the FBG, cholesterol, triglyceride levels, and an improvement in the HDL by Lr-1 indicates that Lr-1 has antidiabetic activity, along with cardioprotective potential, and provides a scientific rationale for the use as an antidiabetic agent.
基金Supported by A grant from the Vice-Chancellor of the Research and Diabetes Research Center of Jundishapour University of Medical Science,No.ETH-393
文摘AIM: To compare freeze-dried strawberry(FDS) beverage and strawberry-flavored drink effects on lipid profile and blood pressure in type 2 diabetic(T2D) patients.METHODS: In a randomized, double-blind, controlled trial, 36 subjects with T2D(23 females; mean ± SE age: 51.57 ± 10 years) were randomly divided into two groups. Participants consumed two cups of either pure FDS beverage(each cup containing 25 g freeze-dried strawberry powder equivalent to one serving of fresh strawberries; intervention group) or an iso-caloric drinkwith strawberry flavoring(similar to the FDS drink in fiber content and color; placebo group) daily for 6 wk. Anthropometric measurements, 3 d, 24 h dietary recall, and fasting blood samples were collected at baseline and at weeks 6 intervention. After lying down and relaxing for approximately 10 min, each participant's blood pressure was recorded in triplicate with 5 min intervals; recordings were made at baseline and the trial end-point. Each participant's lipid profile was assessed before and after intervention.RESULTS: Assessment at the weeks 6 intervention showed a significant reduction from baseline in total cholesterol levels and total cholesterol to high-density lipoprotein cholesterol(HDL-C) ratio in the intervention group(179.01 ± 31.86 to 165.9 ± 32.4 mg/L; P = 0.00 and 3.9 ± 0.88 to 3.6 ± 0.082 mg/L; P = 0.00 respectively), but the change was not significantly different between the two groups(P = 0.07, P = 0.29 respectively). Systolic blood pressure levels were significantly reduced from baseline in both the FDS and placebo drink groups(129.95 ± 14.9 to 114.3 ± 27.5 mm Hg; P = 0.02 and 127.6 ± 15.6 to 122.9 ± 14.47 mm Hg; P = 0.00 respectively), but the reduction was not significantly different between the two groups. Diastolic blood pressure was significantly reduced post-intervention in the FDS drink group compared to placebo group(78.7 ± 7.2 vs 84.4 ± 5.8; P = 0.01), the reduction was also significant within the FDS drink group(84.2 ± 8.03 to 78.7 ± 7.2; P = 0.00). Triglycerides, HDL-C concentrations and anthropometric indices showed no significant differences between or within groups. CONCLUSION: Short-term FDS supplementation improved selected cardiovascular risk factors in subjects with T2 D. Long-term effects on other metabolic biomarkers need to be investigated in future trials.
文摘Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia. Methods: The study comprised of 47 patients with metabolic endotoxemia (the metabolic endotoxemia group) and 43 controls (the control group). Patients in the metabolic endotoxemia group were categorized further into three subgroups including the normal weight group (n=8), the overweight group (n=12) and the obese group (n=27). Height, weight, waist, and hip circumference were measured, and waist-hip ratio (WHR) and body mass index (BMI) were calculated. LBP was determined by ELISA and total cholesterol, triglycerides, high density lipoprotein by the respective enzymatic colorimetric methods. In addition, low density lipoprotein and very low density lipoprotein were determined by Friedewald's formula. Results: The mean waist circumference (WC), hip circumference (HC), BMI, total cholesterol, low density lipoprotein, and LBP of the metabolic endotoxemia group were significantly higher (P<0.05) than those of the control group. WHR, TG, high density lipoprotein and very low density lipoprotein of the metabolic endotoxemia group were not significantly different (P>0.05) from those of the control group. The mean WC, HC, WHR, and BMI of the obese group with metabolic endotoxemia were significantly higher (P<0.05) than those of the overweight group and the normal weight group with metabolic endotoxemia. Significant positive correlations were obtained between BMI and LBP (r=0.610, P=0.001), total cholesterol and LBP (r=0.385, P=0.007), TG and LBP (r=0.356, P=0.014) in patients with metabolic endotoxemia. Conclusions: Metabolic endotoxemia arising from increased circulating level of bacterial derive particles consequent to perturbation in the gut microbial community and the elevated ;serum level of LBP may precede the development of obesity, characterized by dyslipidemia, dysregulation of gut energy harvest, and metabolic energy imbalance.
基金funded by the National Key R&D Program of China(2022YFD1301001)the Natural Science Foundation of China(32072755).
文摘Background High-grain(HG)diets affect lipid metabolism in the liver and mammary tissue of dairy cows,but its effects on muscle and adipose tissue have not been wide evaluated.Thus,the aim of this study is to clarify this issue.Methods Twelve Holstein cows were randomly divided into two groups:conventional diet group(CON,n=6)and the HG diet group(n=6).On day 7 of week 4,rumen fluid was sampled to measure pH,milk was sampled to meas-ure components,and blood was sampled to measure biochemical parameters and fatty acid composition.After the experiment,cows were slaughtered to collect muscle and adipose tissue for fatty acid composition and transcriptome analysis.Results HG feeding decreased the ruminal pH,milk’s fat content and long-chain fatty acid proportion(P<0.05)and increased the proportion of short-and medium-chain fatty acids in the milk(P<0.05)as compared with CON diets.The concentrations of blood cholesterol,low-density lipoprotein,and polyunsaturated fatty acids in the HG cows were lower than those in CON cows(P<0.05).In muscle tissue,HG feeding tended to increase the triacylglycerol(TG)concentration(P<0.10).Transcriptome analysis revealed changes in the biosynthesis of the unsaturated fatty acids pathway,the regulation of lipolysis in the adipocytes pathway,and the PPAR signalling pathway.In adipose tissue,HG feeding increased the concentration of TG and decreased the concentration of C18:1 cis9(P<0.05).At the transcrip-tome level,the fatty acid biosynthesis pathway,linoleic acid metabolism pathway,and PPAR signalling pathway were activated.Conclusion HG feeding leads to subacute rumen acidosis and a decreased milk fat content.The fatty acid profiles in the milk and plasma of dairy cows were changed by HG feeding.In muscle and adipose tissue,HG feeding increased TG concentration and up-regulated the expression of genes related to adipogenesis,while down-regulated the expression of genes related to lipid transport.These results complement our knowledge of the fatty acid composi-tion of muscle and adipose tissue in dairy cows and expand our understanding of the mechanisms by which HG diets affect lipid metabolism in muscle and adipose tissue.
文摘Diabetes is a major health global problem that has reached alarming levels. The present study aims for studying the effect of date palm pollen (<i><span style="font-family:Verdana;">Phoenix dactylifera L</span></i><span style="font-family:Verdana;">.) El-Hayani cultivar on serum glucose and lipids profile in induced diabetic male albino rats. Palm pollen chemically analyzed besides chemical constituents, mineral contents, polyphenols </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> flavonoids. Male Albino rats (36</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">rats </span><span style="font-family:Verdana;">weight 170</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">190</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">gm) were divided </span><span style="font-family:Verdana;">in</span><span style="font-family:Verdana;">to</span><span style="font-family:Verdana;"> 6 groups. 1</span><span style="font-family:Verdana;">: </span><span style="font-family:Verdana;">Normal control (</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">), 2</span><span style="font-family:Verdana;">:</span><span style="font-family:Verdana;"> Alloxanized diabetes control (+) (150</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mg/Kg rat body weight). Diabetic groups 3 and 4 had 0.5%,</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">1.0% date palm pollen, respectively, also diabetic </span><span style="font-family:Verdana;">group</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> 5 and 6 had 100 ppm, 200 ppm date palm pollen extract, respectively. At the end of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">experiment</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (4 weeks) rats were fasted overnight and anesthetized and blood samples were taken for analysis of serum glucose, lipids profile </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> renal-hepatic function parameters, relative organ weight data obtained are </span><span style="font-family:Verdana;">statistically</span><span style="font-family:Verdana;"> analysis. Results showed that the major polyphenolic components were that e-vanillic acid (16.33 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), pyrogallol (15.02 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), epicatechin (11.04 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), catechin (10.96 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g). </span><span style="font-family:Verdana;">While,</span><span style="font-family:Verdana;"> date palm pollen was rich in hesperidin (8.84 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), Kaempferol 3</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">2 p-coumaroyl glucose (6.92 mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g), </span><span style="font-family:Verdana;">hesperitin</span><span style="font-family:Verdana;"> (5.10 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">g), rutin (3.11mg/100</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g) as flavonoids components. Date palm pollen has </span><span style="font-family:Verdana;">high</span><span style="font-family:Verdana;"> content of protein, calcium </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> iron (30.87 g/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g, 510.82 </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> 236.50 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">g), respectively. Also, serum glucose decreased significantly in diabetic groups (3, 4, 5 </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> 6, respectively) (179.47, 137.80, 156.77, 145.47 mg/100</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">mL, respectively). Lipids profile, renal and liver functions were improved </span><span style="font-family:Verdana;">significant</span></span><span style="font-family:Verdana;">ly</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> (P < 0.05) in diabetic groups </span><span style="font-family:Verdana;">which had</span><span style="font-family:Verdana;"> date palm pollen or its extracts.</span></span><span> </span><span style="font-family:Verdana;">It is concluded that the dried date palm pollen 1% in the diet and 200 ppm extract are more effective compared with controlling diabetes mellitus, also improve renal and liver functions. Diabetics are advised to eat date palm pollen</span><span style="font-family:Verdana;"> and</span><span style="font-family:Verdana;"> are considered treatment foods for Diabetes Mellitus.</span>
文摘<div style="text-align:justify;"> <strong>Background:</strong> By the dawn of this modern era of science, the prime challenge of physician is cardiovascular disease (CVD).<span "=""> </span><span "="">The most important modifiable risk factors of CVDs are unhealthy diet, physical inactivity and tobacco use. The effects of unhealthy diet and physical inactivity include abnormal blood lipid, obesity and hypertension. We tried to evaluate and correlate the pattern of lipid profile in obese and non-obese hypertensive patients. <b>Objectives:</b> This study was conducted at medicine department of Cumilla Medical College Hospital. The principal aim was to evaluate the lipid profile in obese and non-obese adult hypertensive patients. <b>Methodology:</b> During this cross sectional analytical study, </span>a total of<span "=""> </span>100 adult hypertensive patients were taken by purposive sampling. Among them 50<span "=""> </span>(group 1) patients were taken those were obese and 50<span "=""> </span>(group 2) patients taken those were non-obese according to BMI measurement on operational definition. Diagnosis of hypertension would be established with the help of ambulatory BP measurements two occasions few minutes apart. The staging of hypertension was done according to JNC7 Criteria. Morning blood samples were taken after 8<span "=""> </span>-<span "=""> </span>12 hours of fasting and lipid profiles were done on authentic laboratories. The laboratory values were interpreted according to the operational definition of dyslipidaemia. The ethical research and review committee approved the study protocol and signed informed consent was obtained from the participants. The statistics was analyzed using the IBM SPSS software of version 19.0.<span "=""> </span><span "="">Statistical significance was set at p < 0.05. <b>Results:</b> Among the two groups, there were 56 (56%) male</span>s and 44 (44%) females. The mean age of group 1 (46.10 ± 11.09) was compared to that of group 2 (45.5 ± 10.6). Lipid profile abnormalities were significantly higher in the stage 2 hypertension<span "=""> </span>(59.62%) and stage 3 hypertension<span "=""> </span>(66.66%), higher in class 2 obese<span "=""> </span>(100%) and class 3 obese subjects<span "=""> </span>(100%),<span "=""> </span>female hypertensive patients had significantly higher BMI than their male counterparts<span "=""> </span>(27.24 ± 3.63<span "=""> </span><span "="">kg/m<sup>2</sup> versus 29.29 ± 3.99</span><span "=""> </span><span "="">kg/m<sup>2</sup>),</span><span "=""> </span>lipid profiles were higher in the female than male hypertensive patients (63.33% vs 55.35%) but only TC was statistically significant (4.45 ± 1.19<span "=""> </span>mmol/l versus 4.86 ± 1.29<span "=""> </span>mmol/l, p < 0.05). Those who were obese had significant high TG (p < 0.001), high TC (p < 0.001) and high LDL-C (p < 0.001). 38<span "=""> </span>(76%) of the obese hypertensive patients had dyslipidaemia whereas 21<span "=""> </span>(42%) of non-obese hypertensive patients had dyslipidaemia. In multivariate regression, TG was significantly and directly associated with BMI of subjects. Dyslipidaemia was more prevalent in the age group 30<span "=""> </span>-<span "=""> </span>59 of adult hypertensive patients. It showed that obese hypertensive patients had significantly higher SBP<span "=""> </span>(p < 0.001), DBP<span "=""> </span>(p < 0.001) than non-obese subjects. The mean TC (4.83 ± 0.95<span "=""> </span>mmol/l versus 4.15 ± 0.57<span "=""> </span>mmol/l, t = -9.70, p < 0.001), TG (2.64 ± 0.67<span "=""> </span>mmol/l versus 2.10 ± 0.45<span "=""> </span>mmol/l, t = -5.37, p < 0.001) and LDL-C (3.00 ± 0.82<span "=""> </span>mmol/l versus 2.44 ± 0.53<span "=""> </span>mmol/l, t = -9.11, p < 0.001) were also significantly higher among the hypertensive obese subjects. The mean HDL-C was however comparable in the two groups (1.25 ± 0.27<span "=""> </span>mmol/l versus 1.24 ± 0.57<span "=""> </span>mmol/l, t = -0.25, p = 0.08)... </div>
