Ischemic stroke is increasing worldwide,and stent intervention has gradually become one of the effective treatments.Owing to its good mechanical properties and biocompatibility,biodegradable Mg-Zn-Y-Nd alloy(ZE21B)has...Ischemic stroke is increasing worldwide,and stent intervention has gradually become one of the effective treatments.Owing to its good mechanical properties and biocompatibility,biodegradable Mg-Zn-Y-Nd alloy(ZE21B)has good application prospects in vascular stents.However,too fast degradation and delayed endothelialization are the bottleneck problem to limit its further application.In this study,the bio-inspired coating barnacle cement cp19k is constructed on ZE21B surface through electrostatic spraying to improve the corrosion resistance and pro-endothelialization ability.The coating was evaluated through electrochemistry,static immersion corrosion,in vitro blood experiments and cell experiments.Cp19k effectively improved the corrosion resistance of the substrate ZE21B,reduced the degradation rate,improved endothelial cell proliferation and migration capabilities,inhibited smooth muscle cells proliferation and regulated contractile phenotype,inhibited macrophage adhesion,regulated macrophage M2 phenotype,and reduced the expression of inflammatory factor of TNF-a and inhibited fibroplasia in vivo.Our data indicated that the barnacle cement cp19k coating had potential application on the surface modification of Mg alloy cerebrovascular stent.展开更多
基金financially supported by the National Key Research and Development Program of China(No.2021YFC2400703)the Joint Fund of the National Natural Science Foundation of China(No.U2004164)+1 种基金Key Scientific and Technological Research Projects in Henan Province(Nos.232102311155 and 232102230106)Zhengzhou University Major Project Cultivation Special Project(No.125-32214076)。
文摘Ischemic stroke is increasing worldwide,and stent intervention has gradually become one of the effective treatments.Owing to its good mechanical properties and biocompatibility,biodegradable Mg-Zn-Y-Nd alloy(ZE21B)has good application prospects in vascular stents.However,too fast degradation and delayed endothelialization are the bottleneck problem to limit its further application.In this study,the bio-inspired coating barnacle cement cp19k is constructed on ZE21B surface through electrostatic spraying to improve the corrosion resistance and pro-endothelialization ability.The coating was evaluated through electrochemistry,static immersion corrosion,in vitro blood experiments and cell experiments.Cp19k effectively improved the corrosion resistance of the substrate ZE21B,reduced the degradation rate,improved endothelial cell proliferation and migration capabilities,inhibited smooth muscle cells proliferation and regulated contractile phenotype,inhibited macrophage adhesion,regulated macrophage M2 phenotype,and reduced the expression of inflammatory factor of TNF-a and inhibited fibroplasia in vivo.Our data indicated that the barnacle cement cp19k coating had potential application on the surface modification of Mg alloy cerebrovascular stent.
