The Gansu-Qinghai contiguous region of the upper Yellow River is located in the transition zone between the Loess Plateau and the Qinghai-Tibet Plateau,characterized by fragile ecosystems and high sensitivity to clima...The Gansu-Qinghai contiguous region of the upper Yellow River is located in the transition zone between the Loess Plateau and the Qinghai-Tibet Plateau,characterized by fragile ecosystems and high sensitivity to climate change.As a critical ecological security barrier and water conservation area,it faces persistent tensions between development demands and ecological protection.Quantitative assessments of how production-living-ecological space(PLES)evolution affects ecological and environmental quality(EEQ)under long-term,multi-scenario conditions remain limited in such vulnerable regions.Understanding PLES-EEQ relationships is essential for optimizing territorial spatial planning and maintaining ecological security in the Yellow River basin.This study utilized land use data from 2000 to 2020 and the FLUS model to simulate PLES evolution from 2030 to 2060 under SSP1,SSP2,and SSP5 scenarios.The analytical framework integrated artificial neural networks and cellular automata with Shared Socioeconomic Pathways to project spatial configurations and assess EEQ in 2035.Living space expanded across all three scenarios while ecological space decreased.Production space increased by 125 km^(2) under SSP5 but declined in other scenarios.The EEQ index in 2035 showed improvements relative to the baseline value(0.4130)in 2020.Medium-to-high quality areas were primarily grassland and forest,whereas low-quality areas consisted mainly of unused land concentrated in the central and western regions.This study reveals a nonlinear relationship between ecological space quantity and quality,showing that structural optimization can enhance EEQ despite area reduction.The findings suggest that strengthening ecological protection redlines and restraining urban expansion are essential for territorial spatial optimization in ecologically fragile regions.展开更多
As one of China's most important ecological conservation regions,the source region of the Yellow River(SRYR)has a fragile ecological environment.Investigating land use transformations and their ecological conseque...As one of China's most important ecological conservation regions,the source region of the Yellow River(SRYR)has a fragile ecological environment.Investigating land use transformations and their ecological consequences in this region is of great significance for optimizing territorial spatial structure and promoting regional sustainable development.Based on the dominant functions of production-living-ecological space(PLES),we employed the land use transfer matrix and the standard deviational ellipse method to elucidate the spatiotemporal evolution characteristics of PLES in the SRYR from 2000 to 2020.Furthermore,the mechanism underlying the differentiation of eco-environmental effects in this region was explored using the optimal parameter-based geographical detector(OPGD)model.Results indicated that ecological space predominated within the PLES of the SRYR,accounting for approximately 98.74%of the total area.Living space was sparsely distributed in township areas with a proportion below 1.00%.Production space was mainly distributed in Guinan County and Gonghe County,accounting for about 1.16%of the area.In terms of the temporal scale,during 2000–2020,the overall eco-environmental quality of the SRYR exhibited an improving trend,primarily driven by the conversion of other ecological spaces into grassland ecological space.Interaction detection results revealed that the interaction between normalized difference vegetation index and gross domestic product was the strongest.In addition,the interaction between precipitation and temperature showed a significant bilinear enhancement effect.This finding suggests that the variations in eco-environmental quality in the SRYR during 2000–2020 have been jointly influenced by natural,climatic,and human factors.This study helps to provide a scientific basis for the rational layout of PLES and guiding ecological restoration efforts in the SRYR.展开更多
In recent years, the uncontrollable risks of urban production-living-ecological(PLE)space have increased sharply, making resilience enhancement essential for sustainable urban development. Based on the social-ecologic...In recent years, the uncontrollable risks of urban production-living-ecological(PLE)space have increased sharply, making resilience enhancement essential for sustainable urban development. Based on the social-ecological system(SES) theory, this study constructs an assessment framework for urban PLE space resilience by analyzing its inherent characteristics. The central urban area of Ganzhou city is taken as a case study to evaluate urban PLE space resilience and diagnose its obstacles. The results are as follows: The PLE space resilience in the central urban area of Ganzhou exhibits gradations and substantial spatial differentiation. The ecological space resilience in the study area was the highest, followed by that of production space, while living space resilience was the lowest. The primary factors influencing PLE space resilience are concentrated in the dimensions of robustness and adaptability. In particular, the robustness of the PLE space is relatively low. Based on these results, targeted spatial resilience governance strategies for the PLE space have been proposed. These strategies serve as theoretical and technical references for the study area. By adopting the PLE space perspective, this paper enriches resilience research and provide theoretical support for sustainable urban development.展开更多
The ecological function of land use is the basis for developing an ecological civilization and realizing sustainable development.This paper may help guide the coordination of economic development and ecological develo...The ecological function of land use is the basis for developing an ecological civilization and realizing sustainable development.This paper may help guide the coordination of economic development and ecological development in China’s coastal border areas.Based on theoretical analysis,this paper studies the spatiotemporal evolution of the functional spaces and the ecological function transitions of land use in the Beibu Gulf Economic Zone(BGEZ)by analyzing patterns,processes,and factors by applying eco-environmental quality index,grid subdivision,kriging interpolation,barycenter model,and Geodetector.This paper constructs a theoretical framework of ecological function transitions of land use based on the research idea of“system-pattern-process-factor”,and carries out empirical research.Some conclusions can be drawn as follows:(1)The ecological space in the BGEZ has continuously decreased,converting mainly into agricultural production space and industrial-mining production space.The production space has expanded slowly.The area of living space in the BGEZ has increased rapidly.(2)The ecological function of land use in the BGEZ has continued to weaken,especially in the southern part of the BGEZ.The“high-sub-high”quality zones of ecological function are retreating to the north.(3)There were more deterioration transition areas than optimization transition areas of ecological function in the BGEZ.The former were mostly located in the central and southern urbanized areas of the BGEZ,whereas the latter were mostly located in the edge zones of district and county units.(4)As for the driving factors of the deterioration transitions of land use ecological function in the BGEZ,the significant trend of“de-ecologization”of the land cover/land use structure was the dominant driving factor;the interactions among the“natural-socioeconomic-managerial”systems were the main recessive factor.The natural system played a fundamental role,and the driving force of natural factors was the strongest.The industrialization,urbanization,and GDP increment in the socioeconomic system and the policy positioning of development intensity in the managerial system played a significant role.The interactions among natural factors,road construction,and industrial non-agricultural transformation had a“fuze”effect on stimulating driving forces.展开更多
Coastal cities hold a special position in the fields of production,living,and ecological research because of their unique wetland resource advantages.However,with global urbanization and rapid economic development,con...Coastal cities hold a special position in the fields of production,living,and ecological research because of their unique wetland resource advantages.However,with global urbanization and rapid economic development,con-flicts among production,living and ecological land are prevalent in coastal cities in the process of maintaining sustainable wetland resources and further developing the social economy.By establishing an SD-PLUS-CCD cou-pling model,this paper analysed the evolution characteristics and driving mechanism of the production-living-ecological space(PLES)and the effects of wetland protection(WLP)on promoting or inhibiting the coordinated development of the PLES in Dongying city during 2005-2060.The results show that(1)from 2005 to 2020,the increase in urban population resulted in a significant transfer of arable land and a reduction of 914 km2 in pro-duction space(PS);(2)from 2020 to 2060,under the WLP scenario,the conversion of wetland ecological space will reduce the PS and living space(LS)by 193.92 km2 and 107.14 km2,respectively,and increase the ecological space(ES)by 327.52 km2;and(3)wetland protection has an inhibitory effect on the coordinated development of PLES in the study area,and the total proportion of noncoordinated areas of PE and living-ecological space will continue to increase during the simulation period.This paper provides a solid theoretical support for the sustain-able management and protection of wetlands in coastal cities and possible PLES conflict patterns and provides a scientific basis for future territorial spatial planning and policy balance analysis.展开更多
As the core of spatial planning in China,delineation of the production-living-ecological space(PLES)refers to dividing the overall land use into three functional spaces.Spatial units are optimally configured as the mo...As the core of spatial planning in China,delineation of the production-living-ecological space(PLES)refers to dividing the overall land use into three functional spaces.Spatial units are optimally configured as the most suitable functional type,while beset by various uncertainties.Weight uncertainties,being affected by subjective preferences,are highly arbitrary and seriously affect PLES.Taking Xuzhou as the study area,this paper studies the perturbation mechanism and response measure of weight uncertainties on PLES.First,weight samples are obtained through quasi-random sampling to serve as sources of uncertainties for input into the optimized delineation of PLES.Next,the Monte Carlo simulation is applied to simulate the spatial probability distribution of PLES.The global sensitivity analysis method is then adopted to identify the main sources that cause uncertainties in the delineation of PLES.Subsequently,the flexible space(FS)of PLES at a certain level of significance is formulated by comparing the distribution probabilities of spatial units for different functional spaces,acting as a countermeasure for the perturbation.The results show that weight uncertainties bring disturbances to the PLES by affecting the multi-criteria evaluation(MCE)of PLES delineation.The PLES is affected by the weight uncertainties of the factors alone or through interactions with other weights.FS is the spatial response measure of PLES when uncertainties occurred at a certain level of significance.The study introduces the perspective of uncertainty for PLES,which contributes toward improving the scientificity and reliability of PLES.展开更多
A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synth...A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synthetic metabolic engineering offers a method to modify and redesign metabolic pathways to increase the nutritional value of crops.We summarize recent advances in the biofortification of key nutrients including provitamin A,vitamin C,vitamin B9,iron,zinc,anthocyanins,flavonoids,and unsaturated fatty acids.We discuss the potential of multi-gene stacking,gene editing,enzyme engineering,and artificial intelligence in synthetic metabolic engineering.We propose future research directions and potential solutions centered on leveraging AI-driven systems biology,precision gene editing,enzyme engineering,agrobacterium-mediated genotype-independent transformation,and modular metabolic engineering strategies to develop next-generation nutritionally enhanced super crops and transform global food systems.展开更多
This study investigates the properties of high-purity starches extracted from Polygonum multiflorum(PMS)and Smilax glabra(SGS).The starches were characterized by scanning electron microscopy,Fouriertransform infrared ...This study investigates the properties of high-purity starches extracted from Polygonum multiflorum(PMS)and Smilax glabra(SGS).The starches were characterized by scanning electron microscopy,Fouriertransform infrared spectroscopy,X-ray diffraction,high-performance anion-exchange chromatography,and differential scanning calorimetry.Significant differences were observed in their morphological,physicochemical,and functional properties.PMS had a smaller particle size(13.68 μm),irregular polygonal shape,A-type,lower water absorption(62.67 %),and higher oil absorption(51.17 %).In contrast,SGS exhibited larger particles(31.75 μm),a nearly spherical shape,B-type,higher crystallinity(50.66 %),and greater amylose content(21.54 %),with superior thermal stability,shear resistance,and gelatinization enthalpy.SGS also contained higher resistant starch(83.28 %) and longer average chain length(20.58 %),but showed lower solubility,swelling power,light transmittance,and freeze-thaw stability.The physicochemical properties differences in crystal pattern and particle morphology between PMS and SGS lead to distinct behaviors during in vitro digestion and fermentation.These findings highlight the potential of medicinal plant starches in functional ingredients and industrial processes.展开更多
Gauss radial basis functions(GRBF)are frequently employed in data fitting and machine learning.Their linear independence property can theoretically guarantee the avoidance of data redundancy.In this paper,one of the m...Gauss radial basis functions(GRBF)are frequently employed in data fitting and machine learning.Their linear independence property can theoretically guarantee the avoidance of data redundancy.In this paper,one of the main contributions is proving this property using linear algebra instead of profound knowledge.This makes it easy to read and understand this fundamental fact.The proof of linear independence of a set of Gauss functions relies on the constructing method for one-dimensional space and on the deducing method for higher dimensions.Additionally,under the condition of preserving the same moments between the original function and interpolating function,both the interpolating existence and uniqueness are proven for GRBF in one-dimensional space.The final work demonstrates the application of the GRBF method to locate lunar olivine.By combining preprocessed data using GRBF with the removing envelope curve method,a program is created to find the position of lunar olivine based on spectrum data,and the numerical experiment shows that it is an effective scheme.展开更多
Saikosaponins are the major pharmacologically active components in Bupleurum genus and exhibit significant application potential in multiple fields such as immune regulation and anti-tumor activity.To elucidate the bi...Saikosaponins are the major pharmacologically active components in Bupleurum genus and exhibit significant application potential in multiple fields such as immune regulation and anti-tumor activity.To elucidate the biosynthetic pathway of saikosaponins,we identified two cytochrome P450 monooxygenases,CYP716A41 and CYP716Y4,in Bupleurum chinense.These enzymes catalyze the C-28 oxidation and C-16 hydroxylation of oleanane-type triterpene skeletons,respectively.The catalytic efficiency of CYP716A41 from a southern B.chinense variety was significantly higher than that from a northern variety.Molecular docking and mutagenesis experiments revealed that amino acid residues at sites 9 and 35 may contribute to this difference in catalytic efficiency.Additionally,under cold stress,the expression levels of both CYP450 genes and the saikosaponin contents in the leaves of southern varieties were significantly higher compared to those in northern varieties.The variation in the catalytic efficiency of CYP716A41 and the differential expression of the two CYP450 genes under cold stress during winter are associated with the differences in saikosaponin biosynthesis in the leaves of southern and northern B.chinense varieties.This is consistent with the distinct medicinal usage practices observed between southern and northern China.展开更多
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s...Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury.展开更多
Nickel-catalyzed borylation of aryl nonaflates with B2pin2 could be realized,which proceeded effectively by means of C—O bond functionalization to afford a wide variety of valuable arylboronates in moderate to excell...Nickel-catalyzed borylation of aryl nonaflates with B2pin2 could be realized,which proceeded effectively by means of C—O bond functionalization to afford a wide variety of valuable arylboronates in moderate to excellent yields with good functionality compatibility.In addition,the gram-scale synthesis and the application of the approach in the late-stage elaboration of aryl nonaflate derived from pterostilbene could also be achieved.展开更多
Let K_(j)/Q,1≤j≤ν,ν≥2 be quadratic fields with pairwise coprime discriminants Dj,and let τ_(kj)^(K_(j))(n)be the divisor function associated to Dedekind zeta function SK_(j)(s).In this paper,we consider a multid...Let K_(j)/Q,1≤j≤ν,ν≥2 be quadratic fields with pairwise coprime discriminants Dj,and let τ_(kj)^(K_(j))(n)be the divisor function associated to Dedekind zeta function SK_(j)(s).In this paper,we consider a multidimensional general divisor problem related to the τ_(kj)^(K_(j))(n)involving several number fields over square integers,by establishing the corresponding asymptotic formula.As an application,we also obtain the asymptotic formula of variance of these coefi icients.展开更多
In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov ...In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov processes,non-stationary signals,and other mathematical disciplines.The aim of the current research article is to first improve the bounds of coefficient-related problems by employing the well-known Carathéodory function.The problems that we are going to improve were obtained by Tang et al.The sharp estimates of the most difficult problem of geometric function theory known as the third-order Hankel determinant are also contributed here.Zalcman and Fekete-Szegöinequalities are also studied here for the defined family of holomorphic functions.展开更多
This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fati...This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fatigue was induced using an upper limb ergometer or a lower limb ergometer,with the load increasing gradually each minute.fNIRS covering the prefrontal cortex and motor cortex were used to collect data during the resting state,both before and after fatigue induction.A two-way ANOVA was conducted to examine differences in oxyhemoglobin(HbO_(2))and functional connectivity before and after fatigue induction in both groups,with the significance level set at 0.05.Exercise-induced fatigue in both the upper and lower limbs leads to a significant decrease in cerebral cortical oxygenation levels.Upper limb fatigue leads to a significant reduction in functional connectivity,there were significant decreases in connectivity within the motor cortex,between the motor cortex and frontal regions,and between the right ventrolateral prefrontal cortex and other frontal regions.Conversely,no significant changes were observed before and after lower limb fatigue.Future studies should focus on examining the extent to which how changes in the cerebral cortex,induced by exercise fatigue,are linked to exercise-and/or performance-related outcomes.展开更多
Functional gastrointestinal disorders(FGIDs),including irritable bowel syndrome(IBS),functional dyspepsia(FD),and gastroesophageal reflux disease(GERD),present persistent diagnostic and therapeutic challenges due to s...Functional gastrointestinal disorders(FGIDs),including irritable bowel syndrome(IBS),functional dyspepsia(FD),and gastroesophageal reflux disease(GERD),present persistent diagnostic and therapeutic challenges due to symptom heterogeneity and the absence of reliable biomarkers.Artificial intelligence(AI)enables the integration of multimodal data to enhance FGID management through precision diagnostics and preventive healthcare.This minireview summarizes recent advancements in AI applications for FGIDs,highlighting progress in diagnostic accuracy,subtype classification,personalized interventions,and preventive strategies inspired by the traditional Chinese medicine concept of“treating the undiseased”.Machine learning and deep learning algorithms have demonstrated value in improving IBS diagnosis,refining FD neuro-gastrointestinal subtyping,and screening for GERD-related complications.Moreover,AI supports dietary,psychological,and integrative medicine-based interventions to improve patient adherence and quality of life.Nonetheless,key challenges remain,including data heterogeneity,limited model interpretability,and the need for robust clinical validation.Future directions emphasize interdisciplinary collaboration,the development of multimodal and explainable AI models,and the creation of patientcentered platforms to facilitate a shift from reactive treatment to proactive prevention.This review provides a systematic framework to guide the clinical application and theoretical innovation of AI in FGIDs.展开更多
In molybdenum chemistry,the oxidative addition of o-quinone or 1,2-dicarbonyl compounds to molybdenum has been widely used in Mo-catalyzed C—C bond construction.The carbonyl oxidative addition to Mo(0)or Mo(Ⅱ)is the...In molybdenum chemistry,the oxidative addition of o-quinone or 1,2-dicarbonyl compounds to molybdenum has been widely used in Mo-catalyzed C—C bond construction.The carbonyl oxidative addition to Mo(0)or Mo(Ⅱ)is the critical elementary reaction of molybdenum catalysis.However,the relevant density functional theory(DFT)studies are relatively scarce,especially regarding the rational selection of functionals.In this work,14 functionals were employed to investigate the Mo-catalyzed carbonyl oxidative addition step.A benchmark study was carried out to evaluate their performance in structure optimization and energy calculation.Analyses of mean absolute error(MAE)and mean squared error(MSE)indicated that the B3LYP-D3(BJ),TPSSh,and ωB97X-D functionals exhibited superior performance in structure optimization.Using the DLPNO-CCSD(T)functional as the reference,the M06,M06-L,and MN15-L functionals exhibited good performance for energy calculation based on the structures optimized using the B3LYP-D3(BJ)functional.In particular,MN15-L provided the best performance with the smallest MAE and MSE.展开更多
Aspergillus species are ubiquitous fungi that produce mycotoxins(secondary metabolites)known as sterigmatocystin and aflatoxins in many different kinds of foods,which leads to serious contamination in agricultural pro...Aspergillus species are ubiquitous fungi that produce mycotoxins(secondary metabolites)known as sterigmatocystin and aflatoxins in many different kinds of foods,which leads to serious contamination in agricultural products,thereby endangering human health.Extensive studies on Aspergillus fungi have been conducted on growth and development,aflatoxin biosynthesis,and their interactions with environment.Here,we summarized a series of functional genes of the main Aspergillus fungi relative to toxins occurrence in foods,which revealed the signal transduction mechanisms of their involvement in growth and development,toxin production,and response to light,anticipating providing theoretical guidance on developing control and prevention technologies for mycotoxin contamination in agricultural products to ensure food safety.展开更多
Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microb...Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microbial inflammatory disease,the precise underlying mechanisms by which periodontitis influences the progression of COPD remains largely unknown.Here,we established COPD accompanied with periodontitis mouse models and observed the pronounced progress in pulmonary symptoms and histopathology,cha racterized by poorer respiratory function,thicke ned bronchial walls,and increased neutrophils infiltration in lung tissue.Mechanistically,periodontitis pathogen Porphyromonas gingivalis(P.gingivalis)relocated in the lung through the respiratory tract and LPS from P.gingivalis promoted the secretion of chemokines CXCL2 and G-CSF of alveolar epithelial cells through NF-κB and p38 MAPK pathways to recruit neutrophils.Furthermore,exposure to P.gingivalis of infiltrated neutrophils released matrix metallopeptidase-8(MMP-8)and neutrophil elastase(NE),which aggravated airway inflammation and tissue damage.These findings indicated that periodontitis could exacerbate COPD via its pathogen P.gingivalis,which translocated in the lung and stimulated neutrophil chemotaxis and activation in the lung.展开更多
Given the broad applicability of carbazole structural moieties in materials science and medicinal chemistry,significant efforts have been devoted to developing efficient synthetic catalytic methodologies to access thi...Given the broad applicability of carbazole structural moieties in materials science and medicinal chemistry,significant efforts have been devoted to developing efficient synthetic catalytic methodologies to access this valuable scaffold.Catalyzed direct Csp^(2)-H functionalization provides an effective and costefficient approach to synthesizing carbazoles from simple and readily available starting materials,ensuring a promising path characterized by excellent atom and step economy.This review highlights the substantial progress made in the last 10 years in advancing catalytic Csp^(2)-H functionalization techniques for synthesizing carbazoles.展开更多
基金funded by the National Natural Science Foundation of China(Grant No.42461038 and No.42161043).
文摘The Gansu-Qinghai contiguous region of the upper Yellow River is located in the transition zone between the Loess Plateau and the Qinghai-Tibet Plateau,characterized by fragile ecosystems and high sensitivity to climate change.As a critical ecological security barrier and water conservation area,it faces persistent tensions between development demands and ecological protection.Quantitative assessments of how production-living-ecological space(PLES)evolution affects ecological and environmental quality(EEQ)under long-term,multi-scenario conditions remain limited in such vulnerable regions.Understanding PLES-EEQ relationships is essential for optimizing territorial spatial planning and maintaining ecological security in the Yellow River basin.This study utilized land use data from 2000 to 2020 and the FLUS model to simulate PLES evolution from 2030 to 2060 under SSP1,SSP2,and SSP5 scenarios.The analytical framework integrated artificial neural networks and cellular automata with Shared Socioeconomic Pathways to project spatial configurations and assess EEQ in 2035.Living space expanded across all three scenarios while ecological space decreased.Production space increased by 125 km^(2) under SSP5 but declined in other scenarios.The EEQ index in 2035 showed improvements relative to the baseline value(0.4130)in 2020.Medium-to-high quality areas were primarily grassland and forest,whereas low-quality areas consisted mainly of unused land concentrated in the central and western regions.This study reveals a nonlinear relationship between ecological space quantity and quality,showing that structural optimization can enhance EEQ despite area reduction.The findings suggest that strengthening ecological protection redlines and restraining urban expansion are essential for territorial spatial optimization in ecologically fragile regions.
基金financially supported by the Qinghai Provincial Applied Basic Research Program,China(2024-ZJ-953)。
文摘As one of China's most important ecological conservation regions,the source region of the Yellow River(SRYR)has a fragile ecological environment.Investigating land use transformations and their ecological consequences in this region is of great significance for optimizing territorial spatial structure and promoting regional sustainable development.Based on the dominant functions of production-living-ecological space(PLES),we employed the land use transfer matrix and the standard deviational ellipse method to elucidate the spatiotemporal evolution characteristics of PLES in the SRYR from 2000 to 2020.Furthermore,the mechanism underlying the differentiation of eco-environmental effects in this region was explored using the optimal parameter-based geographical detector(OPGD)model.Results indicated that ecological space predominated within the PLES of the SRYR,accounting for approximately 98.74%of the total area.Living space was sparsely distributed in township areas with a proportion below 1.00%.Production space was mainly distributed in Guinan County and Gonghe County,accounting for about 1.16%of the area.In terms of the temporal scale,during 2000–2020,the overall eco-environmental quality of the SRYR exhibited an improving trend,primarily driven by the conversion of other ecological spaces into grassland ecological space.Interaction detection results revealed that the interaction between normalized difference vegetation index and gross domestic product was the strongest.In addition,the interaction between precipitation and temperature showed a significant bilinear enhancement effect.This finding suggests that the variations in eco-environmental quality in the SRYR during 2000–2020 have been jointly influenced by natural,climatic,and human factors.This study helps to provide a scientific basis for the rational layout of PLES and guiding ecological restoration efforts in the SRYR.
基金Social Science Foundation Project of Jiangxi Province,No.24GL61D。
文摘In recent years, the uncontrollable risks of urban production-living-ecological(PLE)space have increased sharply, making resilience enhancement essential for sustainable urban development. Based on the social-ecological system(SES) theory, this study constructs an assessment framework for urban PLE space resilience by analyzing its inherent characteristics. The central urban area of Ganzhou city is taken as a case study to evaluate urban PLE space resilience and diagnose its obstacles. The results are as follows: The PLE space resilience in the central urban area of Ganzhou exhibits gradations and substantial spatial differentiation. The ecological space resilience in the study area was the highest, followed by that of production space, while living space resilience was the lowest. The primary factors influencing PLE space resilience are concentrated in the dimensions of robustness and adaptability. In particular, the robustness of the PLE space is relatively low. Based on these results, targeted spatial resilience governance strategies for the PLE space have been proposed. These strategies serve as theoretical and technical references for the study area. By adopting the PLE space perspective, this paper enriches resilience research and provide theoretical support for sustainable urban development.
基金National Natural Science Foundation of China,No.42301313Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.2024GXNSFBA010097National Natural Science Foundation of China,No.41971216。
文摘The ecological function of land use is the basis for developing an ecological civilization and realizing sustainable development.This paper may help guide the coordination of economic development and ecological development in China’s coastal border areas.Based on theoretical analysis,this paper studies the spatiotemporal evolution of the functional spaces and the ecological function transitions of land use in the Beibu Gulf Economic Zone(BGEZ)by analyzing patterns,processes,and factors by applying eco-environmental quality index,grid subdivision,kriging interpolation,barycenter model,and Geodetector.This paper constructs a theoretical framework of ecological function transitions of land use based on the research idea of“system-pattern-process-factor”,and carries out empirical research.Some conclusions can be drawn as follows:(1)The ecological space in the BGEZ has continuously decreased,converting mainly into agricultural production space and industrial-mining production space.The production space has expanded slowly.The area of living space in the BGEZ has increased rapidly.(2)The ecological function of land use in the BGEZ has continued to weaken,especially in the southern part of the BGEZ.The“high-sub-high”quality zones of ecological function are retreating to the north.(3)There were more deterioration transition areas than optimization transition areas of ecological function in the BGEZ.The former were mostly located in the central and southern urbanized areas of the BGEZ,whereas the latter were mostly located in the edge zones of district and county units.(4)As for the driving factors of the deterioration transitions of land use ecological function in the BGEZ,the significant trend of“de-ecologization”of the land cover/land use structure was the dominant driving factor;the interactions among the“natural-socioeconomic-managerial”systems were the main recessive factor.The natural system played a fundamental role,and the driving force of natural factors was the strongest.The industrialization,urbanization,and GDP increment in the socioeconomic system and the policy positioning of development intensity in the managerial system played a significant role.The interactions among natural factors,road construction,and industrial non-agricultural transformation had a“fuze”effect on stimulating driving forces.
基金supported by the Joint Research program for Eco-logical Conservation and High-quality Development of the Yellow River Basin(Grant No.2022-YRUC-01-0103)Watershed Non-point Source Pollution Prevention and Control Technology and Application Demon-stration Project(Grant No.2021YFC3201505)+3 种基金the National Key Re-search and Development Project(Grant No.2016YFC0502106)the Natural Science Foundation of China(Grant No.41476161)the Spe-cial Project of National Natural Science Foundation of China(Grant No.42442035)the Fundamental Research Funds for the Central Uni-versities.
文摘Coastal cities hold a special position in the fields of production,living,and ecological research because of their unique wetland resource advantages.However,with global urbanization and rapid economic development,con-flicts among production,living and ecological land are prevalent in coastal cities in the process of maintaining sustainable wetland resources and further developing the social economy.By establishing an SD-PLUS-CCD cou-pling model,this paper analysed the evolution characteristics and driving mechanism of the production-living-ecological space(PLES)and the effects of wetland protection(WLP)on promoting or inhibiting the coordinated development of the PLES in Dongying city during 2005-2060.The results show that(1)from 2005 to 2020,the increase in urban population resulted in a significant transfer of arable land and a reduction of 914 km2 in pro-duction space(PS);(2)from 2020 to 2060,under the WLP scenario,the conversion of wetland ecological space will reduce the PS and living space(LS)by 193.92 km2 and 107.14 km2,respectively,and increase the ecological space(ES)by 327.52 km2;and(3)wetland protection has an inhibitory effect on the coordinated development of PLES in the study area,and the total proportion of noncoordinated areas of PE and living-ecological space will continue to increase during the simulation period.This paper provides a solid theoretical support for the sustain-able management and protection of wetlands in coastal cities and possible PLES conflict patterns and provides a scientific basis for future territorial spatial planning and policy balance analysis.
基金Under the auspices of National Natural Science Foundation of China(No.42171248,42371273)。
文摘As the core of spatial planning in China,delineation of the production-living-ecological space(PLES)refers to dividing the overall land use into three functional spaces.Spatial units are optimally configured as the most suitable functional type,while beset by various uncertainties.Weight uncertainties,being affected by subjective preferences,are highly arbitrary and seriously affect PLES.Taking Xuzhou as the study area,this paper studies the perturbation mechanism and response measure of weight uncertainties on PLES.First,weight samples are obtained through quasi-random sampling to serve as sources of uncertainties for input into the optimized delineation of PLES.Next,the Monte Carlo simulation is applied to simulate the spatial probability distribution of PLES.The global sensitivity analysis method is then adopted to identify the main sources that cause uncertainties in the delineation of PLES.Subsequently,the flexible space(FS)of PLES at a certain level of significance is formulated by comparing the distribution probabilities of spatial units for different functional spaces,acting as a countermeasure for the perturbation.The results show that weight uncertainties bring disturbances to the PLES by affecting the multi-criteria evaluation(MCE)of PLES delineation.The PLES is affected by the weight uncertainties of the factors alone or through interactions with other weights.FS is the spatial response measure of PLES when uncertainties occurred at a certain level of significance.The study introduces the perspective of uncertainty for PLES,which contributes toward improving the scientificity and reliability of PLES.
基金supported by grants from the Guangxi Science and Technology Major Project(GKAA24206023)the Biological Breeding-National Science and Technology Major Project(2024ZD04077)+2 种基金the National Natural Science Foundation of China(32272120)the National Key Research and Development Program of China(2024YFF1000800)the Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops Major Project(FCBRCE-202502,FCBRCE-202504).
文摘A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synthetic metabolic engineering offers a method to modify and redesign metabolic pathways to increase the nutritional value of crops.We summarize recent advances in the biofortification of key nutrients including provitamin A,vitamin C,vitamin B9,iron,zinc,anthocyanins,flavonoids,and unsaturated fatty acids.We discuss the potential of multi-gene stacking,gene editing,enzyme engineering,and artificial intelligence in synthetic metabolic engineering.We propose future research directions and potential solutions centered on leveraging AI-driven systems biology,precision gene editing,enzyme engineering,agrobacterium-mediated genotype-independent transformation,and modular metabolic engineering strategies to develop next-generation nutritionally enhanced super crops and transform global food systems.
基金supported by the National Natural Science Foundation of China (No.82174074)。
文摘This study investigates the properties of high-purity starches extracted from Polygonum multiflorum(PMS)and Smilax glabra(SGS).The starches were characterized by scanning electron microscopy,Fouriertransform infrared spectroscopy,X-ray diffraction,high-performance anion-exchange chromatography,and differential scanning calorimetry.Significant differences were observed in their morphological,physicochemical,and functional properties.PMS had a smaller particle size(13.68 μm),irregular polygonal shape,A-type,lower water absorption(62.67 %),and higher oil absorption(51.17 %).In contrast,SGS exhibited larger particles(31.75 μm),a nearly spherical shape,B-type,higher crystallinity(50.66 %),and greater amylose content(21.54 %),with superior thermal stability,shear resistance,and gelatinization enthalpy.SGS also contained higher resistant starch(83.28 %) and longer average chain length(20.58 %),but showed lower solubility,swelling power,light transmittance,and freeze-thaw stability.The physicochemical properties differences in crystal pattern and particle morphology between PMS and SGS lead to distinct behaviors during in vitro digestion and fermentation.These findings highlight the potential of medicinal plant starches in functional ingredients and industrial processes.
基金Supported by the National Basic Research Program of China(2012CB025904)Zhengzhou Shengda University of Economics,Business and Management(SD-YB2025085)。
文摘Gauss radial basis functions(GRBF)are frequently employed in data fitting and machine learning.Their linear independence property can theoretically guarantee the avoidance of data redundancy.In this paper,one of the main contributions is proving this property using linear algebra instead of profound knowledge.This makes it easy to read and understand this fundamental fact.The proof of linear independence of a set of Gauss functions relies on the constructing method for one-dimensional space and on the deducing method for higher dimensions.Additionally,under the condition of preserving the same moments between the original function and interpolating function,both the interpolating existence and uniqueness are proven for GRBF in one-dimensional space.The final work demonstrates the application of the GRBF method to locate lunar olivine.By combining preprocessed data using GRBF with the removing envelope curve method,a program is created to find the position of lunar olivine based on spectrum data,and the numerical experiment shows that it is an effective scheme.
基金supported by CARS(CARS-21),the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-032)the Science and Technology Department of Xizang(XZ202401ZY0020)+2 种基金the Science and Technology Department of Sichuan Province(2023YFH0044,2023YFH0018)the Sichuan Province Science Foundation for Distinguished Young Scholars(2022JDJQ0006)the Doctoral Fund of Southwest University of Science and Technology(19ZX7117,21ZX7116).
文摘Saikosaponins are the major pharmacologically active components in Bupleurum genus and exhibit significant application potential in multiple fields such as immune regulation and anti-tumor activity.To elucidate the biosynthetic pathway of saikosaponins,we identified two cytochrome P450 monooxygenases,CYP716A41 and CYP716Y4,in Bupleurum chinense.These enzymes catalyze the C-28 oxidation and C-16 hydroxylation of oleanane-type triterpene skeletons,respectively.The catalytic efficiency of CYP716A41 from a southern B.chinense variety was significantly higher than that from a northern variety.Molecular docking and mutagenesis experiments revealed that amino acid residues at sites 9 and 35 may contribute to this difference in catalytic efficiency.Additionally,under cold stress,the expression levels of both CYP450 genes and the saikosaponin contents in the leaves of southern varieties were significantly higher compared to those in northern varieties.The variation in the catalytic efficiency of CYP716A41 and the differential expression of the two CYP450 genes under cold stress during winter are associated with the differences in saikosaponin biosynthesis in the leaves of southern and northern B.chinense varieties.This is consistent with the distinct medicinal usage practices observed between southern and northern China.
基金supported by the National Natural Science Foundation of China,Nos.82072165 and 82272256(both to XM)the Key Project of Xiangyang Central Hospital,No.2023YZ03(to RM)。
文摘Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury.
文摘Nickel-catalyzed borylation of aryl nonaflates with B2pin2 could be realized,which proceeded effectively by means of C—O bond functionalization to afford a wide variety of valuable arylboronates in moderate to excellent yields with good functionality compatibility.In addition,the gram-scale synthesis and the application of the approach in the late-stage elaboration of aryl nonaflate derived from pterostilbene could also be achieved.
基金Supported in part by NSFC(Nos.12401011,12201214)National Key Research and Development Program of China(No.2021YFA1000700)+3 种基金Shaanxi Fundamental Science Research Project for Mathematics and Physics(No.23JSQ053)Science and Technology Program for Youth New Star of Shaanxi Province(No.2025ZC-KJXX-29)Natural Science Basic Research Program of Shaanxi Province(No.2025JC-YBQN-091)Scientific Research Foundation for Young Talents of WNU(No.2024XJ-QNRC-01)。
文摘Let K_(j)/Q,1≤j≤ν,ν≥2 be quadratic fields with pairwise coprime discriminants Dj,and let τ_(kj)^(K_(j))(n)be the divisor function associated to Dedekind zeta function SK_(j)(s).In this paper,we consider a multidimensional general divisor problem related to the τ_(kj)^(K_(j))(n)involving several number fields over square integers,by establishing the corresponding asymptotic formula.As an application,we also obtain the asymptotic formula of variance of these coefi icients.
基金supported by the NSFC(11561001)the Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT18-A14)+4 种基金the NSF of Inner Mongolia(2022MS01004,2020MS01011)the Higher School Foundation of Inner Mongolia(NJZY20200)the Program for Key Laboratory Construction of Chifeng University(CFXYZD202004)the Research and Innovation Team of Complex Analysis and Nonlinear Dynamic Systems of Chifeng University(cfxykycxtd202005)the Youth Science Foundation of Chifeng University(cfxyqn202133).
文摘In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov processes,non-stationary signals,and other mathematical disciplines.The aim of the current research article is to first improve the bounds of coefficient-related problems by employing the well-known Carathéodory function.The problems that we are going to improve were obtained by Tang et al.The sharp estimates of the most difficult problem of geometric function theory known as the third-order Hankel determinant are also contributed here.Zalcman and Fekete-Szegöinequalities are also studied here for the defined family of holomorphic functions.
基金supported by National Natural Science Foundation of China[NO.11932013].
文摘This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fatigue was induced using an upper limb ergometer or a lower limb ergometer,with the load increasing gradually each minute.fNIRS covering the prefrontal cortex and motor cortex were used to collect data during the resting state,both before and after fatigue induction.A two-way ANOVA was conducted to examine differences in oxyhemoglobin(HbO_(2))and functional connectivity before and after fatigue induction in both groups,with the significance level set at 0.05.Exercise-induced fatigue in both the upper and lower limbs leads to a significant decrease in cerebral cortical oxygenation levels.Upper limb fatigue leads to a significant reduction in functional connectivity,there were significant decreases in connectivity within the motor cortex,between the motor cortex and frontal regions,and between the right ventrolateral prefrontal cortex and other frontal regions.Conversely,no significant changes were observed before and after lower limb fatigue.Future studies should focus on examining the extent to which how changes in the cerebral cortex,induced by exercise fatigue,are linked to exercise-and/or performance-related outcomes.
基金Supported by The Natural Science Foundation of China,No.82374292the Plans for Major Provincial Science and Technology Projects of Anhui Province,No.202303a07020003the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine,No.ZYYCXTD-C-202401.
文摘Functional gastrointestinal disorders(FGIDs),including irritable bowel syndrome(IBS),functional dyspepsia(FD),and gastroesophageal reflux disease(GERD),present persistent diagnostic and therapeutic challenges due to symptom heterogeneity and the absence of reliable biomarkers.Artificial intelligence(AI)enables the integration of multimodal data to enhance FGID management through precision diagnostics and preventive healthcare.This minireview summarizes recent advancements in AI applications for FGIDs,highlighting progress in diagnostic accuracy,subtype classification,personalized interventions,and preventive strategies inspired by the traditional Chinese medicine concept of“treating the undiseased”.Machine learning and deep learning algorithms have demonstrated value in improving IBS diagnosis,refining FD neuro-gastrointestinal subtyping,and screening for GERD-related complications.Moreover,AI supports dietary,psychological,and integrative medicine-based interventions to improve patient adherence and quality of life.Nonetheless,key challenges remain,including data heterogeneity,limited model interpretability,and the need for robust clinical validation.Future directions emphasize interdisciplinary collaboration,the development of multimodal and explainable AI models,and the creation of patientcentered platforms to facilitate a shift from reactive treatment to proactive prevention.This review provides a systematic framework to guide the clinical application and theoretical innovation of AI in FGIDs.
基金Project supported by the Fundamental Research Funds for the Central Universities(No.2042025kf0052)。
文摘In molybdenum chemistry,the oxidative addition of o-quinone or 1,2-dicarbonyl compounds to molybdenum has been widely used in Mo-catalyzed C—C bond construction.The carbonyl oxidative addition to Mo(0)or Mo(Ⅱ)is the critical elementary reaction of molybdenum catalysis.However,the relevant density functional theory(DFT)studies are relatively scarce,especially regarding the rational selection of functionals.In this work,14 functionals were employed to investigate the Mo-catalyzed carbonyl oxidative addition step.A benchmark study was carried out to evaluate their performance in structure optimization and energy calculation.Analyses of mean absolute error(MAE)and mean squared error(MSE)indicated that the B3LYP-D3(BJ),TPSSh,and ωB97X-D functionals exhibited superior performance in structure optimization.Using the DLPNO-CCSD(T)functional as the reference,the M06,M06-L,and MN15-L functionals exhibited good performance for energy calculation based on the structures optimized using the B3LYP-D3(BJ)functional.In particular,MN15-L provided the best performance with the smallest MAE and MSE.
基金supported by the key project of National Natural Sciences Foundation of China(U22A20551,32030085)the Major Project of Hubei Hongshan Laboratory,China(2021hszd015)+2 种基金the Hubei Province Major Science and Technology Special Project,China(2023BBA002)the National Natural Sciences Foundation of China(U22A20551)the National Natural Science Foundation of China Excellent Youth Fund(32422072)。
文摘Aspergillus species are ubiquitous fungi that produce mycotoxins(secondary metabolites)known as sterigmatocystin and aflatoxins in many different kinds of foods,which leads to serious contamination in agricultural products,thereby endangering human health.Extensive studies on Aspergillus fungi have been conducted on growth and development,aflatoxin biosynthesis,and their interactions with environment.Here,we summarized a series of functional genes of the main Aspergillus fungi relative to toxins occurrence in foods,which revealed the signal transduction mechanisms of their involvement in growth and development,toxin production,and response to light,anticipating providing theoretical guidance on developing control and prevention technologies for mycotoxin contamination in agricultural products to ensure food safety.
基金supported by National High Level Hospital Clinical Research Funding,grant nos.BJ-2025-122,BJ2023-126CAMS Innovation Fund for Medical Sciences(CIFMS),grant no.2021-I2M-1050National Natural Science Foundation of China,grant no.82170956。
文摘Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microbial inflammatory disease,the precise underlying mechanisms by which periodontitis influences the progression of COPD remains largely unknown.Here,we established COPD accompanied with periodontitis mouse models and observed the pronounced progress in pulmonary symptoms and histopathology,cha racterized by poorer respiratory function,thicke ned bronchial walls,and increased neutrophils infiltration in lung tissue.Mechanistically,periodontitis pathogen Porphyromonas gingivalis(P.gingivalis)relocated in the lung through the respiratory tract and LPS from P.gingivalis promoted the secretion of chemokines CXCL2 and G-CSF of alveolar epithelial cells through NF-κB and p38 MAPK pathways to recruit neutrophils.Furthermore,exposure to P.gingivalis of infiltrated neutrophils released matrix metallopeptidase-8(MMP-8)and neutrophil elastase(NE),which aggravated airway inflammation and tissue damage.These findings indicated that periodontitis could exacerbate COPD via its pathogen P.gingivalis,which translocated in the lung and stimulated neutrophil chemotaxis and activation in the lung.
基金support and funding by the European Union-Next Generation EU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem (No.ECS00000041-VITALITY and also “Ecosistema TECH4YOU-(Spoke 3-Goal 3.5)MUR is thanked for PRIN-PNRR 2022 project "P2022XKWH7-Circular Waste+3 种基金The University of Perugia is acknowledged for financial support to the university project “Fondo Ricerca di Ateneo,edizione 2022”The National Ph D program in Catalysis coordinated by the University of Perugia is also thankedthe financial supports of key research and development and technology transfer projects of Inner Mongolia Autonomous Region (No.2025KJHZ0008)major special projects of science and technology of Ordos (No.2022EEDSKJZDZX003)。
文摘Given the broad applicability of carbazole structural moieties in materials science and medicinal chemistry,significant efforts have been devoted to developing efficient synthetic catalytic methodologies to access this valuable scaffold.Catalyzed direct Csp^(2)-H functionalization provides an effective and costefficient approach to synthesizing carbazoles from simple and readily available starting materials,ensuring a promising path characterized by excellent atom and step economy.This review highlights the substantial progress made in the last 10 years in advancing catalytic Csp^(2)-H functionalization techniques for synthesizing carbazoles.
