Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SD...Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SDAT)has emerged as a promising area of research.This perspective summarizes the recent NPT-based sonosensitizers in SDAT.Currently,common NPT-based sonosensitizers include curcumin,chlorophyll derivatives,hypericin,and berberine.Compared with other sonosensitizers,natural sources of NPT-based sonosensitizers with reactive oxide species production performance under ultrasound conditions,low biotoxicity,and other additional biological activity make them have application prospects in bacterial removal.Finally,the potential benefits and challenges of NPT-based nanosonosensitizers were also discussed.展开更多
The new edition of the International Production Cost Comparison (IPCC) from ITMF has been published.The report benchmarks manufacturing costs for a range of textile products along the primary textile value chain,disag...The new edition of the International Production Cost Comparison (IPCC) from ITMF has been published.The report benchmarks manufacturing costs for a range of textile products along the primary textile value chain,disaggregated by key cost components at each production stage.展开更多
The products of graphs discussed in this paper are the following four kinds: the Cartesian product of graphs, the tensor product of graphs, the lexicographic product of graphs and the strong direct product of graphs. ...The products of graphs discussed in this paper are the following four kinds: the Cartesian product of graphs, the tensor product of graphs, the lexicographic product of graphs and the strong direct product of graphs. It is proved that:① If the graphs G 1 and G 2 are the connected graphs, then the Cartesian product, the lexicographic product and the strong direct product in the products of graphs, are the path positive graphs. ② If the tensor product is a path positive graph if and only if the graph G 1 and G 2 are the connected graphs, and the graph G 1 or G 2 has an odd cycle and max{ λ 1μ 1,λ nμ m}≥2 in which λ 1 and λ n [ or μ 1 and μ m] are maximum and minimum characteristic values of graph G 1 [ or G 2 ], respectively.展开更多
GS1 is an international standards organization,which focuses on product identification and product data,helping businesses and governments to improve commerce and supply chain.Why trusted data is essential to high-qua...GS1 is an international standards organization,which focuses on product identification and product data,helping businesses and governments to improve commerce and supply chain.Why trusted data is essential to high-quality development?More than 50 years ago,GS1 was initiated with the bar code,a profound transformation of the way we work and live.From then on,a simple scan connected a physical product to its digital identity.It transformed commerce,improving supply chains and enabling safer healthcare.Collaboration between industry and governments,and a strong partnership with ISO and IEC laid the foundations for the global adoption of a common product identification over the past 50 years and all around the world.展开更多
1 Production and Running Status of China’s Refractories Industry in 20241.1 Production and Running Status In 2024,according to the statistical data from The Association of China Refractories Industry,China’s refract...1 Production and Running Status of China’s Refractories Industry in 20241.1 Production and Running Status In 2024,according to the statistical data from The Association of China Refractories Industry,China’s refractories output was 22.0711million tons,decreasing by 3.73%YOY;in which the outputs of dense shaped refractory products,insulating refractory products and monolithic refractories were 11.3163 million tons decreasing by 6.07%YOY,83.77 thousand tons increasing by 11.17%YOY,and 9.9971 million tons decreasing by 2.07%YOY,respectively.The outputs of the main varieties are shown in Fig.1.展开更多
Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International ...Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use(ICH)guildline Q5A(R2)from September 2022 highlights the inclusion of viral vector-based gene therapy products in safety discussions,emphasizing controls in material sourcing,testing,and viral clearance[1].Detecting adventitious virus contamination is complex due to the unique characteristics of gene therapy products and the limitations of routine testing methods.The US Food and Drug Administration(FDA)recommends incorporating routine and specific virus detection methods,including those outlined in various pharmacopeias.Existing control methods have limitations,prompting the need for highly sensitive and broad-spectrum detection approaches.Unlike traditional biological products,gene therapy products primarily consist of live viruses,necessitating methods that distinguish between the main virus and adventitious viruses.Current virus detection techniques,such as polymerase chain reaction(PCR),sequencing,mass spectrometry,and DNA microarrays[2e4],have their drawbacks.展开更多
To address the challenges associated with existing separated zone oil production technologies,such as incompatibility with pump inspection operations,short effective working life,and poor communication reliability,an ...To address the challenges associated with existing separated zone oil production technologies,such as incompatibility with pump inspection operations,short effective working life,and poor communication reliability,an innovative electromagnetic coupling intelligent zonal oil production technology has been proposed.The core and accessory tools have been developed and applied in field tests.This technology employs a pipe string structure incorporation a release sub,which separates the production and allocation pipe strings.When the two strings are docked downhole,electromagnetic coupling enables close-range wireless transmission of electrical power and signals between the strings,powering multiple downhole intelligent production allocators(IPAs)and enabling two-way communication.Core tools adapted to the complex working conditions downhole were developed,including downhole electricity&signal transmission equipment based on electromagnetic coupling(EST),IPAs,and ground communication controllers(GCCs).Accessory tools,including large-diameter release sub anchor and cable-crossing packers,have also been technically finalized.Field tests conducted on ten wells in Daqing Oilfield demonstrated that the downhole docking of the two strings was convenient and reliable,and the EST worked stably.Real-time monitoring of flow rate,pressure and temperature in separate layers and regulation of zonal fluid production were also achieved.This technology has enhanced reservoir understanding and achieved practical production results of increased oil output with reduced water cut.展开更多
Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered arou...Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered around the"Taihu Snow"brand,its products cover suite products (such as pillowcases,quilt covers,sheets),quilt cores,silk scarves and otheremerging retail products.展开更多
Natural products,with their remarkable structural and biological diversity,have historically served as a vital bridge between chemistry,the life sciences,and medicine.They not only provide essential scaffolds for drug...Natural products,with their remarkable structural and biological diversity,have historically served as a vital bridge between chemistry,the life sciences,and medicine.They not only provide essential scaffolds for drug discovery but also inspire innovative strategies in drug development.The biomimetic synthesis of natural products employs principles from biomimicry,applying inspiration from biogenetic processes to design synthetic strategies that mimic biosynthetic processes.Biomimetic synthesis is a highly efficient approach in synthetic chemistry,as it addresses critical challenges in the synthesis of structurally complex natural products with significant biological and medicinal importance.It has gained widespread attention from researchers in chemistry,biology,pharmacy,and related fields,underscoring its interdisciplinary impact.In this perspective,we present recent advances and challenges in the biomimetic synthesis of natural products,along with the significance and prospects of this field,highlighting the transformative potential of biomimetic synthesis strategies for both chemical and biosynthetic approaches to natural product synthesis in the pursuit of novel therapeutic agents.展开更多
OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-perf...OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS)was utilized to identify the chemical composition and authenticate the active constituents of XHPWS,ensuring rigorous quality control across batches.A dextran sulfate sodium(DSS)-induced UC model was established in C57BL/6 mice,which were treated with XHPWS in vivo.The efficacy against UC was assessed by measuring parameters such as body weight,disease activity index(DAI)scores,and colon length.Levels of inflammatory cytokines,including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-alpha(TNF-α),in colonic tissue were evaluated using enzymelinked immunosorbent assay(ELISA).Histological analysis of colon sections was conducted using hematoxylin and eosin staining.A network pharmacology approach was employed to explore the mechanisms of XHPWS and to predict its potential targets in UC treatment.Predicted protein expressions in colonic tissue were validated using immune-ohistochemistry(IHC)and Western blotting techniques.RESULTS:XHPWS effectively alle via ted DSS-induced UC symptoms in mice,as evidenced by restored body weight,reduced colon shortening,and decreased DAI scores.Histopathological examination revealed that XHPWS significantly reduced intestinal inflammatory infiltration,restored intestinal epithelial permeability,and increased goblet cell count.Network pharmacology analysis identified 63 active compounds in XHPWS and suggested that it might target 35 potential proteins associated with UC treatment.Functional enrichment analysis indicated that the protective mechanism of XHPWS could be related to the advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway.Notably,quercetin,kaempferol,wogonin,and nobiletin,the main components of XHPWS,showed strong correlations with the core targets.Additionally,experimental validation demonstrated that XHPWS significantly decreased levels of inflammatory cytokines interleukin 6(IL-6),interleukin 1 beta(IL-1β),and tumor necrosis factor alpha(TNF-α)in UC mice,while downregulating the expression of proteins related to the AGE-RAGE pathway.CONCLUSION:Our study demonstrated that XHPWS effectively alle via tes colitis symptoms and inflammation in UC mice,potentially through the regulation of the AGE-RAGE pathway.These findings provide strong evidence for the therapeutic potential of XHPWS in UC treatment,thereby broadening its clinical applications.展开更多
Variation in the vocal behavior of nonhuman vertebrates includes graded transitions and more dramatic changes.Wapiti males produce a reproductive bugle that has a fundamental frequency that surpasses 2,000 Hz with evi...Variation in the vocal behavior of nonhuman vertebrates includes graded transitions and more dramatic changes.Wapiti males produce a reproductive bugle that has a fundamental frequency that surpasses 2,000 Hz with evidence of biphonation and other nonlinear phenomena.Here,we analyze the acoustic structure of captive wapiti vocalizations to compare the male bugle with 3 categories of distress vocalizations:neonate distress(capture)calls,calf isolation calls,and adult female isolation calls.These 4 high-arousal call categories serve a common general function in recruiting conspecifics but occur in different behavioral contexts(capture,isolation,reproduction).Our goal was to distinguish characteristics that vary in graded steps that may correspond to an animal’s age or size from characteristics that are unique to the bugle.Characteristics of the high and loud fundamental(G0)varied in an age/size-graded manner with a decrease in minimum G0,an increase in the maximum and range of G0,with no evidence of sex differences.The nonlinear phenomena of deterministic chaos,biphonation,and frequency jumps were present in all 4 call categories and became more common from the distress vocalizations of neonates to calves to adult females to the male bugle.Two temporal characteristics sharply distinguished the bugle from the 3 categories of distress vocalizations:these included a prolonged call duration and a maximum G0 that occurred much later in the call for the bugle than for distress vocalizations.Our results suggest that distress vocalizations of different age groups and the reproductive bugle of wapiti share a high G0,with age/size-graded changes in G0 and nonlinear phenomena,but differ sharply in temporal characteristics.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Ports are crucial to the economy of many nations;thus, numerous studies have been conducted on port efficiency and productivity. This study analyses the efficiency and productivity of some major global ports namely, P...Ports are crucial to the economy of many nations;thus, numerous studies have been conducted on port efficiency and productivity. This study analyses the efficiency and productivity of some major global ports namely, Port of Singapore, Rotterdam, Antwerp and Durban. The main objectives of this study are to determine the level of operational efficiency of the mentioned ports, measure and evaluate the ports’ productivity changes and lastly to investigate the factors influencing the productivity changes of the ports studied. To achieve these objectives, Data Envelopment Analysis (DEA-BCC) model was used to determine the technical and operational efficiencies of the ports and Malmquist productivity index was employed to calculate the various productivity levels. The results of the study can guide stakeholders to formulate their operational strategies for port efficiency and productivity. The study also has policy suggestions that are uniquely targeted to Africa’s issues and potential.展开更多
Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in signific...Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in significant heterogeneity within subsea natural gas hydrate-bearing sediments.However,the influence of permeability heterogeneity on production performance during depressurization with controlled sand production remains inadequately understood.In this study,a multiphase,multi-component mathematical model is developed to simulate depressurization with controlled sand production in methane hydrate-bearing sediments,incorporating geological conditions representative of unconsolidated argillaceous siltstone hydrate deposits in the Shenhu area of the South China Sea.The effects of permeability heterogeneity-specifically,horizontal autocorrelation length and global permeability heterogeneity-on production performance during depressurization with sand production are investigated using geostatistical modeling combined with finite difference method based numerical simulations.Results show that as the horizontal autocorrelation length of permeability distribution increases,cumulative gas production first rises and then declines,reaching its peak at λ_(Dh)=0.1,whereas sand production steadily increases.In addition,higher formation permeability heterogeneity results in increased cumulative gas and sand production,suggesting that greater heterogeneity promotesmethane hydrate decomposition and gas recovery.These findings can offer valuable insights for optimizing future field development of hydrate-bearing sediments by depressurization with controlled sand production.展开更多
In 2012, Ponraj et al. defined a concept of k-product cordial labeling as follows: Let f be a map from V(G)to { 0,1,⋯,k−1 }where k is an integer, 1≤k≤| V(G) |. For each edge uvassign the label f(u)f(v)(modk). f is c...In 2012, Ponraj et al. defined a concept of k-product cordial labeling as follows: Let f be a map from V(G)to { 0,1,⋯,k−1 }where k is an integer, 1≤k≤| V(G) |. For each edge uvassign the label f(u)f(v)(modk). f is called a k-product cordial labeling if | vf(i)−vf(j) |≤1, and | ef(i)−ef(j) |≤1, i,j∈{ 0,1,⋯,k−1 }, where vf(x)and ef(x)denote the number of vertices and edges respectively labeled with x (x=0,1,⋯,k−1). Motivated by this concept, we further studied and established that several families of graphs admit k-product cordial labeling. In this paper, we show that the path graphs Pnadmit k-product cordial labeling.展开更多
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
基金supported by the Innovation and Entrepreneurship Training Program for College Students(X2025102911746,X2025102910483).
文摘Natural product(NPT)derived from traditional Chinese medicine has a rich history as an integral part of Chinese healthcare for thousands of years.Recently,the application of NPT in sonodynamic antibacterial therapy(SDAT)has emerged as a promising area of research.This perspective summarizes the recent NPT-based sonosensitizers in SDAT.Currently,common NPT-based sonosensitizers include curcumin,chlorophyll derivatives,hypericin,and berberine.Compared with other sonosensitizers,natural sources of NPT-based sonosensitizers with reactive oxide species production performance under ultrasound conditions,low biotoxicity,and other additional biological activity make them have application prospects in bacterial removal.Finally,the potential benefits and challenges of NPT-based nanosonosensitizers were also discussed.
文摘The new edition of the International Production Cost Comparison (IPCC) from ITMF has been published.The report benchmarks manufacturing costs for a range of textile products along the primary textile value chain,disaggregated by key cost components at each production stage.
文摘The products of graphs discussed in this paper are the following four kinds: the Cartesian product of graphs, the tensor product of graphs, the lexicographic product of graphs and the strong direct product of graphs. It is proved that:① If the graphs G 1 and G 2 are the connected graphs, then the Cartesian product, the lexicographic product and the strong direct product in the products of graphs, are the path positive graphs. ② If the tensor product is a path positive graph if and only if the graph G 1 and G 2 are the connected graphs, and the graph G 1 or G 2 has an odd cycle and max{ λ 1μ 1,λ nμ m}≥2 in which λ 1 and λ n [ or μ 1 and μ m] are maximum and minimum characteristic values of graph G 1 [ or G 2 ], respectively.
文摘GS1 is an international standards organization,which focuses on product identification and product data,helping businesses and governments to improve commerce and supply chain.Why trusted data is essential to high-quality development?More than 50 years ago,GS1 was initiated with the bar code,a profound transformation of the way we work and live.From then on,a simple scan connected a physical product to its digital identity.It transformed commerce,improving supply chains and enabling safer healthcare.Collaboration between industry and governments,and a strong partnership with ISO and IEC laid the foundations for the global adoption of a common product identification over the past 50 years and all around the world.
文摘1 Production and Running Status of China’s Refractories Industry in 20241.1 Production and Running Status In 2024,according to the statistical data from The Association of China Refractories Industry,China’s refractories output was 22.0711million tons,decreasing by 3.73%YOY;in which the outputs of dense shaped refractory products,insulating refractory products and monolithic refractories were 11.3163 million tons decreasing by 6.07%YOY,83.77 thousand tons increasing by 11.17%YOY,and 9.9971 million tons decreasing by 2.07%YOY,respectively.The outputs of the main varieties are shown in Fig.1.
基金financially supported by Beijing Municipal Science&Technology Commission,China(Grant No.:Z221100007922015)Youth Development Research Foundation of National Institutes for Food and Drug Control,China(Grant No.:2020B1).
文摘Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use(ICH)guildline Q5A(R2)from September 2022 highlights the inclusion of viral vector-based gene therapy products in safety discussions,emphasizing controls in material sourcing,testing,and viral clearance[1].Detecting adventitious virus contamination is complex due to the unique characteristics of gene therapy products and the limitations of routine testing methods.The US Food and Drug Administration(FDA)recommends incorporating routine and specific virus detection methods,including those outlined in various pharmacopeias.Existing control methods have limitations,prompting the need for highly sensitive and broad-spectrum detection approaches.Unlike traditional biological products,gene therapy products primarily consist of live viruses,necessitating methods that distinguish between the main virus and adventitious viruses.Current virus detection techniques,such as polymerase chain reaction(PCR),sequencing,mass spectrometry,and DNA microarrays[2e4],have their drawbacks.
基金Supported by the National Natural Science Foundation of China(52374067)PetroChina Scientific Research and Technology Development Project(2021ZG12)PetroChina Technology Project(2023ZZ09).
文摘To address the challenges associated with existing separated zone oil production technologies,such as incompatibility with pump inspection operations,short effective working life,and poor communication reliability,an innovative electromagnetic coupling intelligent zonal oil production technology has been proposed.The core and accessory tools have been developed and applied in field tests.This technology employs a pipe string structure incorporation a release sub,which separates the production and allocation pipe strings.When the two strings are docked downhole,electromagnetic coupling enables close-range wireless transmission of electrical power and signals between the strings,powering multiple downhole intelligent production allocators(IPAs)and enabling two-way communication.Core tools adapted to the complex working conditions downhole were developed,including downhole electricity&signal transmission equipment based on electromagnetic coupling(EST),IPAs,and ground communication controllers(GCCs).Accessory tools,including large-diameter release sub anchor and cable-crossing packers,have also been technically finalized.Field tests conducted on ten wells in Daqing Oilfield demonstrated that the downhole docking of the two strings was convenient and reliable,and the EST worked stably.Real-time monitoring of flow rate,pressure and temperature in separate layers and regulation of zonal fluid production were also achieved.This technology has enhanced reservoir understanding and achieved practical production results of increased oil output with reduced water cut.
文摘Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered around the"Taihu Snow"brand,its products cover suite products (such as pillowcases,quilt covers,sheets),quilt cores,silk scarves and otheremerging retail products.
基金financially supported by the National Key Research and Development Program of China(2023YFC3503902)the National Natural Science Foundation of China(82430108,82293681(82293680),and 82321004)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(2022B1515120015 and 2024A1515030103)the Guangdong Major Project of Basic and Applied Basic Research(2023B0303000026)the Science and Technology Projects in Guangzhou(202102070001)。
文摘Natural products,with their remarkable structural and biological diversity,have historically served as a vital bridge between chemistry,the life sciences,and medicine.They not only provide essential scaffolds for drug discovery but also inspire innovative strategies in drug development.The biomimetic synthesis of natural products employs principles from biomimicry,applying inspiration from biogenetic processes to design synthetic strategies that mimic biosynthetic processes.Biomimetic synthesis is a highly efficient approach in synthetic chemistry,as it addresses critical challenges in the synthesis of structurally complex natural products with significant biological and medicinal importance.It has gained widespread attention from researchers in chemistry,biology,pharmacy,and related fields,underscoring its interdisciplinary impact.In this perspective,we present recent advances and challenges in the biomimetic synthesis of natural products,along with the significance and prospects of this field,highlighting the transformative potential of biomimetic synthesis strategies for both chemical and biosynthetic approaches to natural product synthesis in the pursuit of novel therapeutic agents.
基金the Guangdong Provincial Basic and Applied Basic Research Project:Mechanistic Study on the Regulation of Inflammatory Microenvironment and Improvement of Ulcerative Colitis by Lingnan Traditional Medicine Ficus Pandurata Hance through Wilms'Tumor 1-associating Protein-Mediated RNA Methyltransferase Promoting Toll Like Receptor 4 m6A Modification(2023A1515011699)the Zhongshan Medical Research Project:Mechanistic Study on the Action of Xiahuo Pingwei San in the Treatment of Ulcerative Colitis(2022A020446)。
文摘OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS)was utilized to identify the chemical composition and authenticate the active constituents of XHPWS,ensuring rigorous quality control across batches.A dextran sulfate sodium(DSS)-induced UC model was established in C57BL/6 mice,which were treated with XHPWS in vivo.The efficacy against UC was assessed by measuring parameters such as body weight,disease activity index(DAI)scores,and colon length.Levels of inflammatory cytokines,including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-alpha(TNF-α),in colonic tissue were evaluated using enzymelinked immunosorbent assay(ELISA).Histological analysis of colon sections was conducted using hematoxylin and eosin staining.A network pharmacology approach was employed to explore the mechanisms of XHPWS and to predict its potential targets in UC treatment.Predicted protein expressions in colonic tissue were validated using immune-ohistochemistry(IHC)and Western blotting techniques.RESULTS:XHPWS effectively alle via ted DSS-induced UC symptoms in mice,as evidenced by restored body weight,reduced colon shortening,and decreased DAI scores.Histopathological examination revealed that XHPWS significantly reduced intestinal inflammatory infiltration,restored intestinal epithelial permeability,and increased goblet cell count.Network pharmacology analysis identified 63 active compounds in XHPWS and suggested that it might target 35 potential proteins associated with UC treatment.Functional enrichment analysis indicated that the protective mechanism of XHPWS could be related to the advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway.Notably,quercetin,kaempferol,wogonin,and nobiletin,the main components of XHPWS,showed strong correlations with the core targets.Additionally,experimental validation demonstrated that XHPWS significantly decreased levels of inflammatory cytokines interleukin 6(IL-6),interleukin 1 beta(IL-1β),and tumor necrosis factor alpha(TNF-α)in UC mice,while downregulating the expression of proteins related to the AGE-RAGE pathway.CONCLUSION:Our study demonstrated that XHPWS effectively alle via tes colitis symptoms and inflammation in UC mice,potentially through the regulation of the AGE-RAGE pathway.These findings provide strong evidence for the therapeutic potential of XHPWS in UC treatment,thereby broadening its clinical applications.
基金The University of Winnipeg and The University of Winnipeg Foundation contributed funding to this research.
文摘Variation in the vocal behavior of nonhuman vertebrates includes graded transitions and more dramatic changes.Wapiti males produce a reproductive bugle that has a fundamental frequency that surpasses 2,000 Hz with evidence of biphonation and other nonlinear phenomena.Here,we analyze the acoustic structure of captive wapiti vocalizations to compare the male bugle with 3 categories of distress vocalizations:neonate distress(capture)calls,calf isolation calls,and adult female isolation calls.These 4 high-arousal call categories serve a common general function in recruiting conspecifics but occur in different behavioral contexts(capture,isolation,reproduction).Our goal was to distinguish characteristics that vary in graded steps that may correspond to an animal’s age or size from characteristics that are unique to the bugle.Characteristics of the high and loud fundamental(G0)varied in an age/size-graded manner with a decrease in minimum G0,an increase in the maximum and range of G0,with no evidence of sex differences.The nonlinear phenomena of deterministic chaos,biphonation,and frequency jumps were present in all 4 call categories and became more common from the distress vocalizations of neonates to calves to adult females to the male bugle.Two temporal characteristics sharply distinguished the bugle from the 3 categories of distress vocalizations:these included a prolonged call duration and a maximum G0 that occurred much later in the call for the bugle than for distress vocalizations.Our results suggest that distress vocalizations of different age groups and the reproductive bugle of wapiti share a high G0,with age/size-graded changes in G0 and nonlinear phenomena,but differ sharply in temporal characteristics.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Ports are crucial to the economy of many nations;thus, numerous studies have been conducted on port efficiency and productivity. This study analyses the efficiency and productivity of some major global ports namely, Port of Singapore, Rotterdam, Antwerp and Durban. The main objectives of this study are to determine the level of operational efficiency of the mentioned ports, measure and evaluate the ports’ productivity changes and lastly to investigate the factors influencing the productivity changes of the ports studied. To achieve these objectives, Data Envelopment Analysis (DEA-BCC) model was used to determine the technical and operational efficiencies of the ports and Malmquist productivity index was employed to calculate the various productivity levels. The results of the study can guide stakeholders to formulate their operational strategies for port efficiency and productivity. The study also has policy suggestions that are uniquely targeted to Africa’s issues and potential.
基金funded by the National Key Research and Development Program of China(grant number 2023YFC3009204)the National Natural Science Foundation of China(grant number 52174015).
文摘Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in significant heterogeneity within subsea natural gas hydrate-bearing sediments.However,the influence of permeability heterogeneity on production performance during depressurization with controlled sand production remains inadequately understood.In this study,a multiphase,multi-component mathematical model is developed to simulate depressurization with controlled sand production in methane hydrate-bearing sediments,incorporating geological conditions representative of unconsolidated argillaceous siltstone hydrate deposits in the Shenhu area of the South China Sea.The effects of permeability heterogeneity-specifically,horizontal autocorrelation length and global permeability heterogeneity-on production performance during depressurization with sand production are investigated using geostatistical modeling combined with finite difference method based numerical simulations.Results show that as the horizontal autocorrelation length of permeability distribution increases,cumulative gas production first rises and then declines,reaching its peak at λ_(Dh)=0.1,whereas sand production steadily increases.In addition,higher formation permeability heterogeneity results in increased cumulative gas and sand production,suggesting that greater heterogeneity promotesmethane hydrate decomposition and gas recovery.These findings can offer valuable insights for optimizing future field development of hydrate-bearing sediments by depressurization with controlled sand production.
文摘In 2012, Ponraj et al. defined a concept of k-product cordial labeling as follows: Let f be a map from V(G)to { 0,1,⋯,k−1 }where k is an integer, 1≤k≤| V(G) |. For each edge uvassign the label f(u)f(v)(modk). f is called a k-product cordial labeling if | vf(i)−vf(j) |≤1, and | ef(i)−ef(j) |≤1, i,j∈{ 0,1,⋯,k−1 }, where vf(x)and ef(x)denote the number of vertices and edges respectively labeled with x (x=0,1,⋯,k−1). Motivated by this concept, we further studied and established that several families of graphs admit k-product cordial labeling. In this paper, we show that the path graphs Pnadmit k-product cordial labeling.
