The new edition of the International Production Cost Comparison (IPCC) from ITMF has been published.The report benchmarks manufacturing costs for a range of textile products along the primary textile value chain,disag...The new edition of the International Production Cost Comparison (IPCC) from ITMF has been published.The report benchmarks manufacturing costs for a range of textile products along the primary textile value chain,disaggregated by key cost components at each production stage.展开更多
GS1 is an international standards organization,which focuses on product identification and product data,helping businesses and governments to improve commerce and supply chain.Why trusted data is essential to high-qua...GS1 is an international standards organization,which focuses on product identification and product data,helping businesses and governments to improve commerce and supply chain.Why trusted data is essential to high-quality development?More than 50 years ago,GS1 was initiated with the bar code,a profound transformation of the way we work and live.From then on,a simple scan connected a physical product to its digital identity.It transformed commerce,improving supply chains and enabling safer healthcare.Collaboration between industry and governments,and a strong partnership with ISO and IEC laid the foundations for the global adoption of a common product identification over the past 50 years and all around the world.展开更多
1 Production and Running Status of China’s Refractories Industry in 20241.1 Production and Running Status In 2024,according to the statistical data from The Association of China Refractories Industry,China’s refract...1 Production and Running Status of China’s Refractories Industry in 20241.1 Production and Running Status In 2024,according to the statistical data from The Association of China Refractories Industry,China’s refractories output was 22.0711million tons,decreasing by 3.73%YOY;in which the outputs of dense shaped refractory products,insulating refractory products and monolithic refractories were 11.3163 million tons decreasing by 6.07%YOY,83.77 thousand tons increasing by 11.17%YOY,and 9.9971 million tons decreasing by 2.07%YOY,respectively.The outputs of the main varieties are shown in Fig.1.展开更多
Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International ...Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use(ICH)guildline Q5A(R2)from September 2022 highlights the inclusion of viral vector-based gene therapy products in safety discussions,emphasizing controls in material sourcing,testing,and viral clearance[1].Detecting adventitious virus contamination is complex due to the unique characteristics of gene therapy products and the limitations of routine testing methods.The US Food and Drug Administration(FDA)recommends incorporating routine and specific virus detection methods,including those outlined in various pharmacopeias.Existing control methods have limitations,prompting the need for highly sensitive and broad-spectrum detection approaches.Unlike traditional biological products,gene therapy products primarily consist of live viruses,necessitating methods that distinguish between the main virus and adventitious viruses.Current virus detection techniques,such as polymerase chain reaction(PCR),sequencing,mass spectrometry,and DNA microarrays[2e4],have their drawbacks.展开更多
To address the challenges associated with existing separated zone oil production technologies,such as incompatibility with pump inspection operations,short effective working life,and poor communication reliability,an ...To address the challenges associated with existing separated zone oil production technologies,such as incompatibility with pump inspection operations,short effective working life,and poor communication reliability,an innovative electromagnetic coupling intelligent zonal oil production technology has been proposed.The core and accessory tools have been developed and applied in field tests.This technology employs a pipe string structure incorporation a release sub,which separates the production and allocation pipe strings.When the two strings are docked downhole,electromagnetic coupling enables close-range wireless transmission of electrical power and signals between the strings,powering multiple downhole intelligent production allocators(IPAs)and enabling two-way communication.Core tools adapted to the complex working conditions downhole were developed,including downhole electricity&signal transmission equipment based on electromagnetic coupling(EST),IPAs,and ground communication controllers(GCCs).Accessory tools,including large-diameter release sub anchor and cable-crossing packers,have also been technically finalized.Field tests conducted on ten wells in Daqing Oilfield demonstrated that the downhole docking of the two strings was convenient and reliable,and the EST worked stably.Real-time monitoring of flow rate,pressure and temperature in separate layers and regulation of zonal fluid production were also achieved.This technology has enhanced reservoir understanding and achieved practical production results of increased oil output with reduced water cut.展开更多
Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered arou...Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered around the"Taihu Snow"brand,its products cover suite products (such as pillowcases,quilt covers,sheets),quilt cores,silk scarves and otheremerging retail products.展开更多
Natural products,with their remarkable structural and biological diversity,have historically served as a vital bridge between chemistry,the life sciences,and medicine.They not only provide essential scaffolds for drug...Natural products,with their remarkable structural and biological diversity,have historically served as a vital bridge between chemistry,the life sciences,and medicine.They not only provide essential scaffolds for drug discovery but also inspire innovative strategies in drug development.The biomimetic synthesis of natural products employs principles from biomimicry,applying inspiration from biogenetic processes to design synthetic strategies that mimic biosynthetic processes.Biomimetic synthesis is a highly efficient approach in synthetic chemistry,as it addresses critical challenges in the synthesis of structurally complex natural products with significant biological and medicinal importance.It has gained widespread attention from researchers in chemistry,biology,pharmacy,and related fields,underscoring its interdisciplinary impact.In this perspective,we present recent advances and challenges in the biomimetic synthesis of natural products,along with the significance and prospects of this field,highlighting the transformative potential of biomimetic synthesis strategies for both chemical and biosynthetic approaches to natural product synthesis in the pursuit of novel therapeutic agents.展开更多
OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-perf...OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS)was utilized to identify the chemical composition and authenticate the active constituents of XHPWS,ensuring rigorous quality control across batches.A dextran sulfate sodium(DSS)-induced UC model was established in C57BL/6 mice,which were treated with XHPWS in vivo.The efficacy against UC was assessed by measuring parameters such as body weight,disease activity index(DAI)scores,and colon length.Levels of inflammatory cytokines,including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-alpha(TNF-α),in colonic tissue were evaluated using enzymelinked immunosorbent assay(ELISA).Histological analysis of colon sections was conducted using hematoxylin and eosin staining.A network pharmacology approach was employed to explore the mechanisms of XHPWS and to predict its potential targets in UC treatment.Predicted protein expressions in colonic tissue were validated using immune-ohistochemistry(IHC)and Western blotting techniques.RESULTS:XHPWS effectively alle via ted DSS-induced UC symptoms in mice,as evidenced by restored body weight,reduced colon shortening,and decreased DAI scores.Histopathological examination revealed that XHPWS significantly reduced intestinal inflammatory infiltration,restored intestinal epithelial permeability,and increased goblet cell count.Network pharmacology analysis identified 63 active compounds in XHPWS and suggested that it might target 35 potential proteins associated with UC treatment.Functional enrichment analysis indicated that the protective mechanism of XHPWS could be related to the advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway.Notably,quercetin,kaempferol,wogonin,and nobiletin,the main components of XHPWS,showed strong correlations with the core targets.Additionally,experimental validation demonstrated that XHPWS significantly decreased levels of inflammatory cytokines interleukin 6(IL-6),interleukin 1 beta(IL-1β),and tumor necrosis factor alpha(TNF-α)in UC mice,while downregulating the expression of proteins related to the AGE-RAGE pathway.CONCLUSION:Our study demonstrated that XHPWS effectively alle via tes colitis symptoms and inflammation in UC mice,potentially through the regulation of the AGE-RAGE pathway.These findings provide strong evidence for the therapeutic potential of XHPWS in UC treatment,thereby broadening its clinical applications.展开更多
Variation in the vocal behavior of nonhuman vertebrates includes graded transitions and more dramatic changes.Wapiti males produce a reproductive bugle that has a fundamental frequency that surpasses 2,000 Hz with evi...Variation in the vocal behavior of nonhuman vertebrates includes graded transitions and more dramatic changes.Wapiti males produce a reproductive bugle that has a fundamental frequency that surpasses 2,000 Hz with evidence of biphonation and other nonlinear phenomena.Here,we analyze the acoustic structure of captive wapiti vocalizations to compare the male bugle with 3 categories of distress vocalizations:neonate distress(capture)calls,calf isolation calls,and adult female isolation calls.These 4 high-arousal call categories serve a common general function in recruiting conspecifics but occur in different behavioral contexts(capture,isolation,reproduction).Our goal was to distinguish characteristics that vary in graded steps that may correspond to an animal’s age or size from characteristics that are unique to the bugle.Characteristics of the high and loud fundamental(G0)varied in an age/size-graded manner with a decrease in minimum G0,an increase in the maximum and range of G0,with no evidence of sex differences.The nonlinear phenomena of deterministic chaos,biphonation,and frequency jumps were present in all 4 call categories and became more common from the distress vocalizations of neonates to calves to adult females to the male bugle.Two temporal characteristics sharply distinguished the bugle from the 3 categories of distress vocalizations:these included a prolonged call duration and a maximum G0 that occurred much later in the call for the bugle than for distress vocalizations.Our results suggest that distress vocalizations of different age groups and the reproductive bugle of wapiti share a high G0,with age/size-graded changes in G0 and nonlinear phenomena,but differ sharply in temporal characteristics.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Ports are crucial to the economy of many nations;thus, numerous studies have been conducted on port efficiency and productivity. This study analyses the efficiency and productivity of some major global ports namely, P...Ports are crucial to the economy of many nations;thus, numerous studies have been conducted on port efficiency and productivity. This study analyses the efficiency and productivity of some major global ports namely, Port of Singapore, Rotterdam, Antwerp and Durban. The main objectives of this study are to determine the level of operational efficiency of the mentioned ports, measure and evaluate the ports’ productivity changes and lastly to investigate the factors influencing the productivity changes of the ports studied. To achieve these objectives, Data Envelopment Analysis (DEA-BCC) model was used to determine the technical and operational efficiencies of the ports and Malmquist productivity index was employed to calculate the various productivity levels. The results of the study can guide stakeholders to formulate their operational strategies for port efficiency and productivity. The study also has policy suggestions that are uniquely targeted to Africa’s issues and potential.展开更多
Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in signific...Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in significant heterogeneity within subsea natural gas hydrate-bearing sediments.However,the influence of permeability heterogeneity on production performance during depressurization with controlled sand production remains inadequately understood.In this study,a multiphase,multi-component mathematical model is developed to simulate depressurization with controlled sand production in methane hydrate-bearing sediments,incorporating geological conditions representative of unconsolidated argillaceous siltstone hydrate deposits in the Shenhu area of the South China Sea.The effects of permeability heterogeneity-specifically,horizontal autocorrelation length and global permeability heterogeneity-on production performance during depressurization with sand production are investigated using geostatistical modeling combined with finite difference method based numerical simulations.Results show that as the horizontal autocorrelation length of permeability distribution increases,cumulative gas production first rises and then declines,reaching its peak at λ_(Dh)=0.1,whereas sand production steadily increases.In addition,higher formation permeability heterogeneity results in increased cumulative gas and sand production,suggesting that greater heterogeneity promotesmethane hydrate decomposition and gas recovery.These findings can offer valuable insights for optimizing future field development of hydrate-bearing sediments by depressurization with controlled sand production.展开更多
In 2012, Ponraj et al. defined a concept of k-product cordial labeling as follows: Let f be a map from V(G)to { 0,1,⋯,k−1 }where k is an integer, 1≤k≤| V(G) |. For each edge uvassign the label f(u)f(v)(modk). f is c...In 2012, Ponraj et al. defined a concept of k-product cordial labeling as follows: Let f be a map from V(G)to { 0,1,⋯,k−1 }where k is an integer, 1≤k≤| V(G) |. For each edge uvassign the label f(u)f(v)(modk). f is called a k-product cordial labeling if | vf(i)−vf(j) |≤1, and | ef(i)−ef(j) |≤1, i,j∈{ 0,1,⋯,k−1 }, where vf(x)and ef(x)denote the number of vertices and edges respectively labeled with x (x=0,1,⋯,k−1). Motivated by this concept, we further studied and established that several families of graphs admit k-product cordial labeling. In this paper, we show that the path graphs Pnadmit k-product cordial labeling.展开更多
Bangladesh’s principal grain,rice,is essential to the nation’s agricultural economy and food security.In light of the obstacles and possibilities for increasing domestic output,this study looks at Bangladesh’s food...Bangladesh’s principal grain,rice,is essential to the nation’s agricultural economy and food security.In light of the obstacles and possibilities for increasing domestic output,this study looks at Bangladesh’s food productivity and degree of self-sufficiency in rice production.Even though the nation has made significant progress in rice production,problems including population growth,land degradation,climate change,and poor infrastructure still have an impact on total productivity.To examine the trajectory of Bangladesh’s agricultural sector from 1973 to 2023 through the following economic lenses:agricultural input use,GDP contribution,employment rate,trade trends,critical development indicators,and domestic rice demand and production.The data were chosen based on their accessibility,geographical context,relevance to the study’s aims,and time constraints.According to this study,rice production increased from 9.9 million tons in 1973 to 39.1 million tons in 2023,demonstrating the nation’s continuous efforts to increase agricultural output to satisfy rising market demand.展开更多
Exosomes,nanosized extracellular vesicles(30-150 nm),play a crucial role in intercellular communication and are promising biomarkers and therapeutic agents in oncology,neurodegenerative disorders,and immunotherapy.How...Exosomes,nanosized extracellular vesicles(30-150 nm),play a crucial role in intercellular communication and are promising biomarkers and therapeutic agents in oncology,neurodegenerative disorders,and immunotherapy.However,their widespread clinical adoption is constrained by challenges in scalable production,efficient purification,and regulatory standardization.This review critically evaluates recent advancements in exosome bioprocessing,including cell source optimization,culture refinement,and next-generation isolation technologies such as microfluidic microarrays and EXODUS systems.Additionally,we address the limitations of current exosome standardization efforts and propose harmonized protocols to enhance reproducibility.Future research should focus on integrating scalable bioreactor-based systems and artificial intelligence-driven quality control frameworks to accelerate exosome applications in precision medicine and regenerative therapy.展开更多
Shale gas wells often face challenges in maintaining continuous and stable production due to their coexistence with high-and low-pressure wells within the same development block,which leads to issues involving mixed-p...Shale gas wells often face challenges in maintaining continuous and stable production due to their coexistence with high-and low-pressure wells within the same development block,which leads to issues involving mixed-pressure flows.Traditional pipeline optimization methods used in conventional gas well blocks fail to address the unique needs of shale gas wells,such as the precise planning of airflow paths,pressure distribution,and compression.This study proposes a pressure-controlled production optimization strategy specifically designed for shale gas wells operating under mixed-pressure flow conditions.The strategy aims to improve production stability and optimize system efficiency.The decline in production and pressure for individual wells over time is forecasted using a predictive model that accounts for key factors of system optimization,such as reservoir depletion,wellbore conditions,and equipment performance.Additionally,the model predicts the timing and impact of liquid loading,which can significantly affect production.The optimization process involves analyzing the existing gathering pipeline network to determine the most efficient flow directions and compression strategies based on these predictions,while the strategy involves adjusting compressor settings,optimizing flow rates,and planning pressure distribution across the network to maximize productivity while maintaining system stability.By implementing these strategies,this study significantly improves gas well productivity and enhances the adaptability and efficiency of the gathering and transportation system.The proposed approach provides systematic technical solutions and practical guidance for the efficient development and stable production of shale gas fields,ensuring more robust and sustainable pipeline operations.展开更多
The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-...The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-speed shears as emulsification equipment.The primary purpose is to manufacture nano/micro-suspensions using solid lipid particles(SLPs).The study also exhaustively introduces and analyzes the regulatory schemes for process parameters and formulations at various stages of production.The process and formulation endured optimization through orthog-onal or single-factor tests at various production steps:laboratory research,small-scale trial production,and pilot production.Quality standards for the product were determined,and key parameters were obtained at each stage.The laboratory research demonstrated that the optimal SLPs comprised 15 mL 3%polyvinyl alcohol(PVA)per 1.0 g tilmicosin and 2.5 g carnauba wax(WAX).During small-scale production,modifications were made to the volume of the aqueous phase,emulsifier concentration,and emulsification strength,setting them to 16 mL,5%,and 2200 r/min,respectively.In the pilot production stage,the shear time was considered optimal at eight min.The impurity,content,polydispersion coefficient(PDI),and size of the pilot product were<3%,5%,0385 and 2.64μm,respectively.Among the several parameters studied,heating temperature,drug-lipid ratio,and emulsifier concentration were identified as the main factors affecting product quality,and they were regulated at 100℃,1:3,and 5%,respectively.A novel hot melt emulsification shear method aided the development of a new solid lipid-based suspension from its preliminary stages in the laboratory to pilot production.This innovation is expected to enhance solid lipid-based suspensions'industrial evolution extensively.展开更多
文摘The new edition of the International Production Cost Comparison (IPCC) from ITMF has been published.The report benchmarks manufacturing costs for a range of textile products along the primary textile value chain,disaggregated by key cost components at each production stage.
文摘GS1 is an international standards organization,which focuses on product identification and product data,helping businesses and governments to improve commerce and supply chain.Why trusted data is essential to high-quality development?More than 50 years ago,GS1 was initiated with the bar code,a profound transformation of the way we work and live.From then on,a simple scan connected a physical product to its digital identity.It transformed commerce,improving supply chains and enabling safer healthcare.Collaboration between industry and governments,and a strong partnership with ISO and IEC laid the foundations for the global adoption of a common product identification over the past 50 years and all around the world.
文摘1 Production and Running Status of China’s Refractories Industry in 20241.1 Production and Running Status In 2024,according to the statistical data from The Association of China Refractories Industry,China’s refractories output was 22.0711million tons,decreasing by 3.73%YOY;in which the outputs of dense shaped refractory products,insulating refractory products and monolithic refractories were 11.3163 million tons decreasing by 6.07%YOY,83.77 thousand tons increasing by 11.17%YOY,and 9.9971 million tons decreasing by 2.07%YOY,respectively.The outputs of the main varieties are shown in Fig.1.
基金financially supported by Beijing Municipal Science&Technology Commission,China(Grant No.:Z221100007922015)Youth Development Research Foundation of National Institutes for Food and Drug Control,China(Grant No.:2020B1).
文摘Adventitious agents,comprising unintentionally introduced microorganisms in the production of biological products,pose a significant challenge in ensuring the safety of gene therapy products.The revised International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use(ICH)guildline Q5A(R2)from September 2022 highlights the inclusion of viral vector-based gene therapy products in safety discussions,emphasizing controls in material sourcing,testing,and viral clearance[1].Detecting adventitious virus contamination is complex due to the unique characteristics of gene therapy products and the limitations of routine testing methods.The US Food and Drug Administration(FDA)recommends incorporating routine and specific virus detection methods,including those outlined in various pharmacopeias.Existing control methods have limitations,prompting the need for highly sensitive and broad-spectrum detection approaches.Unlike traditional biological products,gene therapy products primarily consist of live viruses,necessitating methods that distinguish between the main virus and adventitious viruses.Current virus detection techniques,such as polymerase chain reaction(PCR),sequencing,mass spectrometry,and DNA microarrays[2e4],have their drawbacks.
基金Supported by the National Natural Science Foundation of China(52374067)PetroChina Scientific Research and Technology Development Project(2021ZG12)PetroChina Technology Project(2023ZZ09).
文摘To address the challenges associated with existing separated zone oil production technologies,such as incompatibility with pump inspection operations,short effective working life,and poor communication reliability,an innovative electromagnetic coupling intelligent zonal oil production technology has been proposed.The core and accessory tools have been developed and applied in field tests.This technology employs a pipe string structure incorporation a release sub,which separates the production and allocation pipe strings.When the two strings are docked downhole,electromagnetic coupling enables close-range wireless transmission of electrical power and signals between the strings,powering multiple downhole intelligent production allocators(IPAs)and enabling two-way communication.Core tools adapted to the complex working conditions downhole were developed,including downhole electricity&signal transmission equipment based on electromagnetic coupling(EST),IPAs,and ground communication controllers(GCCs).Accessory tools,including large-diameter release sub anchor and cable-crossing packers,have also been technically finalized.Field tests conducted on ten wells in Daqing Oilfield demonstrated that the downhole docking of the two strings was convenient and reliable,and the EST worked stably.Real-time monitoring of flow rate,pressure and temperature in separate layers and regulation of zonal fluid production were also achieved.This technology has enhanced reservoir understanding and achieved practical production results of increased oil output with reduced water cut.
文摘Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered around the"Taihu Snow"brand,its products cover suite products (such as pillowcases,quilt covers,sheets),quilt cores,silk scarves and otheremerging retail products.
基金financially supported by the National Key Research and Development Program of China(2023YFC3503902)the National Natural Science Foundation of China(82430108,82293681(82293680),and 82321004)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(2022B1515120015 and 2024A1515030103)the Guangdong Major Project of Basic and Applied Basic Research(2023B0303000026)the Science and Technology Projects in Guangzhou(202102070001)。
文摘Natural products,with their remarkable structural and biological diversity,have historically served as a vital bridge between chemistry,the life sciences,and medicine.They not only provide essential scaffolds for drug discovery but also inspire innovative strategies in drug development.The biomimetic synthesis of natural products employs principles from biomimicry,applying inspiration from biogenetic processes to design synthetic strategies that mimic biosynthetic processes.Biomimetic synthesis is a highly efficient approach in synthetic chemistry,as it addresses critical challenges in the synthesis of structurally complex natural products with significant biological and medicinal importance.It has gained widespread attention from researchers in chemistry,biology,pharmacy,and related fields,underscoring its interdisciplinary impact.In this perspective,we present recent advances and challenges in the biomimetic synthesis of natural products,along with the significance and prospects of this field,highlighting the transformative potential of biomimetic synthesis strategies for both chemical and biosynthetic approaches to natural product synthesis in the pursuit of novel therapeutic agents.
基金the Guangdong Provincial Basic and Applied Basic Research Project:Mechanistic Study on the Regulation of Inflammatory Microenvironment and Improvement of Ulcerative Colitis by Lingnan Traditional Medicine Ficus Pandurata Hance through Wilms'Tumor 1-associating Protein-Mediated RNA Methyltransferase Promoting Toll Like Receptor 4 m6A Modification(2023A1515011699)the Zhongshan Medical Research Project:Mechanistic Study on the Action of Xiahuo Pingwei San in the Treatment of Ulcerative Colitis(2022A020446)。
文摘OBJECTIVE:To evaluate the therapeutic effects of Xiahuo Pingwei San(夏藿平胃散,XHPWS)on ulcerative colitis(UC)in mice and to explore the underlying mechanisms through a network pharmacology approach.METHODS:Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS)was utilized to identify the chemical composition and authenticate the active constituents of XHPWS,ensuring rigorous quality control across batches.A dextran sulfate sodium(DSS)-induced UC model was established in C57BL/6 mice,which were treated with XHPWS in vivo.The efficacy against UC was assessed by measuring parameters such as body weight,disease activity index(DAI)scores,and colon length.Levels of inflammatory cytokines,including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-alpha(TNF-α),in colonic tissue were evaluated using enzymelinked immunosorbent assay(ELISA).Histological analysis of colon sections was conducted using hematoxylin and eosin staining.A network pharmacology approach was employed to explore the mechanisms of XHPWS and to predict its potential targets in UC treatment.Predicted protein expressions in colonic tissue were validated using immune-ohistochemistry(IHC)and Western blotting techniques.RESULTS:XHPWS effectively alle via ted DSS-induced UC symptoms in mice,as evidenced by restored body weight,reduced colon shortening,and decreased DAI scores.Histopathological examination revealed that XHPWS significantly reduced intestinal inflammatory infiltration,restored intestinal epithelial permeability,and increased goblet cell count.Network pharmacology analysis identified 63 active compounds in XHPWS and suggested that it might target 35 potential proteins associated with UC treatment.Functional enrichment analysis indicated that the protective mechanism of XHPWS could be related to the advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway.Notably,quercetin,kaempferol,wogonin,and nobiletin,the main components of XHPWS,showed strong correlations with the core targets.Additionally,experimental validation demonstrated that XHPWS significantly decreased levels of inflammatory cytokines interleukin 6(IL-6),interleukin 1 beta(IL-1β),and tumor necrosis factor alpha(TNF-α)in UC mice,while downregulating the expression of proteins related to the AGE-RAGE pathway.CONCLUSION:Our study demonstrated that XHPWS effectively alle via tes colitis symptoms and inflammation in UC mice,potentially through the regulation of the AGE-RAGE pathway.These findings provide strong evidence for the therapeutic potential of XHPWS in UC treatment,thereby broadening its clinical applications.
基金The University of Winnipeg and The University of Winnipeg Foundation contributed funding to this research.
文摘Variation in the vocal behavior of nonhuman vertebrates includes graded transitions and more dramatic changes.Wapiti males produce a reproductive bugle that has a fundamental frequency that surpasses 2,000 Hz with evidence of biphonation and other nonlinear phenomena.Here,we analyze the acoustic structure of captive wapiti vocalizations to compare the male bugle with 3 categories of distress vocalizations:neonate distress(capture)calls,calf isolation calls,and adult female isolation calls.These 4 high-arousal call categories serve a common general function in recruiting conspecifics but occur in different behavioral contexts(capture,isolation,reproduction).Our goal was to distinguish characteristics that vary in graded steps that may correspond to an animal’s age or size from characteristics that are unique to the bugle.Characteristics of the high and loud fundamental(G0)varied in an age/size-graded manner with a decrease in minimum G0,an increase in the maximum and range of G0,with no evidence of sex differences.The nonlinear phenomena of deterministic chaos,biphonation,and frequency jumps were present in all 4 call categories and became more common from the distress vocalizations of neonates to calves to adult females to the male bugle.Two temporal characteristics sharply distinguished the bugle from the 3 categories of distress vocalizations:these included a prolonged call duration and a maximum G0 that occurred much later in the call for the bugle than for distress vocalizations.Our results suggest that distress vocalizations of different age groups and the reproductive bugle of wapiti share a high G0,with age/size-graded changes in G0 and nonlinear phenomena,but differ sharply in temporal characteristics.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Ports are crucial to the economy of many nations;thus, numerous studies have been conducted on port efficiency and productivity. This study analyses the efficiency and productivity of some major global ports namely, Port of Singapore, Rotterdam, Antwerp and Durban. The main objectives of this study are to determine the level of operational efficiency of the mentioned ports, measure and evaluate the ports’ productivity changes and lastly to investigate the factors influencing the productivity changes of the ports studied. To achieve these objectives, Data Envelopment Analysis (DEA-BCC) model was used to determine the technical and operational efficiencies of the ports and Malmquist productivity index was employed to calculate the various productivity levels. The results of the study can guide stakeholders to formulate their operational strategies for port efficiency and productivity. The study also has policy suggestions that are uniquely targeted to Africa’s issues and potential.
基金funded by the National Key Research and Development Program of China(grant number 2023YFC3009204)the National Natural Science Foundation of China(grant number 52174015).
文摘Field tests have demonstrated that depressurization with controlled sand production is an effective technique for natural gas hydrate extraction.Variations in depositional environments and processes result in significant heterogeneity within subsea natural gas hydrate-bearing sediments.However,the influence of permeability heterogeneity on production performance during depressurization with controlled sand production remains inadequately understood.In this study,a multiphase,multi-component mathematical model is developed to simulate depressurization with controlled sand production in methane hydrate-bearing sediments,incorporating geological conditions representative of unconsolidated argillaceous siltstone hydrate deposits in the Shenhu area of the South China Sea.The effects of permeability heterogeneity-specifically,horizontal autocorrelation length and global permeability heterogeneity-on production performance during depressurization with sand production are investigated using geostatistical modeling combined with finite difference method based numerical simulations.Results show that as the horizontal autocorrelation length of permeability distribution increases,cumulative gas production first rises and then declines,reaching its peak at λ_(Dh)=0.1,whereas sand production steadily increases.In addition,higher formation permeability heterogeneity results in increased cumulative gas and sand production,suggesting that greater heterogeneity promotesmethane hydrate decomposition and gas recovery.These findings can offer valuable insights for optimizing future field development of hydrate-bearing sediments by depressurization with controlled sand production.
文摘In 2012, Ponraj et al. defined a concept of k-product cordial labeling as follows: Let f be a map from V(G)to { 0,1,⋯,k−1 }where k is an integer, 1≤k≤| V(G) |. For each edge uvassign the label f(u)f(v)(modk). f is called a k-product cordial labeling if | vf(i)−vf(j) |≤1, and | ef(i)−ef(j) |≤1, i,j∈{ 0,1,⋯,k−1 }, where vf(x)and ef(x)denote the number of vertices and edges respectively labeled with x (x=0,1,⋯,k−1). Motivated by this concept, we further studied and established that several families of graphs admit k-product cordial labeling. In this paper, we show that the path graphs Pnadmit k-product cordial labeling.
文摘Bangladesh’s principal grain,rice,is essential to the nation’s agricultural economy and food security.In light of the obstacles and possibilities for increasing domestic output,this study looks at Bangladesh’s food productivity and degree of self-sufficiency in rice production.Even though the nation has made significant progress in rice production,problems including population growth,land degradation,climate change,and poor infrastructure still have an impact on total productivity.To examine the trajectory of Bangladesh’s agricultural sector from 1973 to 2023 through the following economic lenses:agricultural input use,GDP contribution,employment rate,trade trends,critical development indicators,and domestic rice demand and production.The data were chosen based on their accessibility,geographical context,relevance to the study’s aims,and time constraints.According to this study,rice production increased from 9.9 million tons in 1973 to 39.1 million tons in 2023,demonstrating the nation’s continuous efforts to increase agricultural output to satisfy rising market demand.
基金supported by the Shanghai Clinical Research Center of Plastic and Reconstructive Surgery,funded by the Science and Technology Commission of Shanghai Municipality(grant no.22MC1940300)the Shanghai Key Research Center—Shanghai Research Center for Plastic Surgery(grant no.2023ZZ02023).
文摘Exosomes,nanosized extracellular vesicles(30-150 nm),play a crucial role in intercellular communication and are promising biomarkers and therapeutic agents in oncology,neurodegenerative disorders,and immunotherapy.However,their widespread clinical adoption is constrained by challenges in scalable production,efficient purification,and regulatory standardization.This review critically evaluates recent advancements in exosome bioprocessing,including cell source optimization,culture refinement,and next-generation isolation technologies such as microfluidic microarrays and EXODUS systems.Additionally,we address the limitations of current exosome standardization efforts and propose harmonized protocols to enhance reproducibility.Future research should focus on integrating scalable bioreactor-based systems and artificial intelligence-driven quality control frameworks to accelerate exosome applications in precision medicine and regenerative therapy.
基金supported by the National Natural Science Foundation of China under Grant 52325402,52274057 and 52074340the National Key R&D Program of China under Grant 2023YFB4104200+1 种基金the Major Scientific and Technological Projects of CNOOC under Grant CCL2022RCPS0397RSN111 Project under Grant B08028.
文摘Shale gas wells often face challenges in maintaining continuous and stable production due to their coexistence with high-and low-pressure wells within the same development block,which leads to issues involving mixed-pressure flows.Traditional pipeline optimization methods used in conventional gas well blocks fail to address the unique needs of shale gas wells,such as the precise planning of airflow paths,pressure distribution,and compression.This study proposes a pressure-controlled production optimization strategy specifically designed for shale gas wells operating under mixed-pressure flow conditions.The strategy aims to improve production stability and optimize system efficiency.The decline in production and pressure for individual wells over time is forecasted using a predictive model that accounts for key factors of system optimization,such as reservoir depletion,wellbore conditions,and equipment performance.Additionally,the model predicts the timing and impact of liquid loading,which can significantly affect production.The optimization process involves analyzing the existing gathering pipeline network to determine the most efficient flow directions and compression strategies based on these predictions,while the strategy involves adjusting compressor settings,optimizing flow rates,and planning pressure distribution across the network to maximize productivity while maintaining system stability.By implementing these strategies,this study significantly improves gas well productivity and enhances the adaptability and efficiency of the gathering and transportation system.The proposed approach provides systematic technical solutions and practical guidance for the efficient development and stable production of shale gas fields,ensuring more robust and sustainable pipeline operations.
基金supported by the Fundamental Research Funds for the Central Universities(2662020DKPY008)the National Natural Science Foundation of China(grant No.31772797)。
文摘The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-speed shears as emulsification equipment.The primary purpose is to manufacture nano/micro-suspensions using solid lipid particles(SLPs).The study also exhaustively introduces and analyzes the regulatory schemes for process parameters and formulations at various stages of production.The process and formulation endured optimization through orthog-onal or single-factor tests at various production steps:laboratory research,small-scale trial production,and pilot production.Quality standards for the product were determined,and key parameters were obtained at each stage.The laboratory research demonstrated that the optimal SLPs comprised 15 mL 3%polyvinyl alcohol(PVA)per 1.0 g tilmicosin and 2.5 g carnauba wax(WAX).During small-scale production,modifications were made to the volume of the aqueous phase,emulsifier concentration,and emulsification strength,setting them to 16 mL,5%,and 2200 r/min,respectively.In the pilot production stage,the shear time was considered optimal at eight min.The impurity,content,polydispersion coefficient(PDI),and size of the pilot product were<3%,5%,0385 and 2.64μm,respectively.Among the several parameters studied,heating temperature,drug-lipid ratio,and emulsifier concentration were identified as the main factors affecting product quality,and they were regulated at 100℃,1:3,and 5%,respectively.A novel hot melt emulsification shear method aided the development of a new solid lipid-based suspension from its preliminary stages in the laboratory to pilot production.This innovation is expected to enhance solid lipid-based suspensions'industrial evolution extensively.
