The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,...The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.展开更多
Highway is an important channel to connect regional economic development,and is an indispensable part of modern transportation system.In view of the extensive nature of highway cover space and the existence of diversi...Highway is an important channel to connect regional economic development,and is an indispensable part of modern transportation system.In view of the extensive nature of highway cover space and the existence of diversified construction environment,climate and geological influence in highway construction,soft soil foundation is one of the more typical geological forms.With wide distribution in our country,seen as a big difficulty,highway construction technology and directly affect the quality of highway construction,cost,if not properly handled,will cause the soft soil foundation highway engineering structure is not stable,prone to accidents in use.In this paper,we study the treatment of soft soil foundation in highway construction,and put forward some reasonable Suggestions.展开更多
With the advent of the big data era,real-time data analysis and decision-support systems have been recognized as essential tools for enhancing enterprise competitiveness and optimizing the decision-making process.This...With the advent of the big data era,real-time data analysis and decision-support systems have been recognized as essential tools for enhancing enterprise competitiveness and optimizing the decision-making process.This study aims to explore the development strategies of real-time data analysis and decision-support systems,and analyze their application status and future development trends in various industries.The article first reviews the basic concepts and importance of real-time data analysis and decision-support systems,and then discusses in detail the key technical aspects such as system architecture,data collection and processing,analysis methods,and visualization techniques.展开更多
This article investigates the dynamic relationship between technology and AI(artificial intelligence)and the role that societal requirements play in pushing AI research and adoption.Technology has advanced dramaticall...This article investigates the dynamic relationship between technology and AI(artificial intelligence)and the role that societal requirements play in pushing AI research and adoption.Technology has advanced dramatically throughout the years,providing the groundwork for the rise of AI.AI systems have achieved incredible feats in various disciplines thanks to advancements in computer power,data availability,and complex algorithms.On the other hand,society’s needs for efficiency,enhanced healthcare,environmental sustainability,and personalized experiences have worked as powerful accelerators for AI’s progress.This article digs into how technology empowers AI and how societal needs dictate its progress,emphasizing their symbiotic relationship.The findings underline the significance of responsible AI research,which considers both technological prowess and ethical issues,to ensure that AI continues to serve the greater good.展开更多
Film coating is an important unit operation to produce solid dosage forms,thereby,the monitoring of this process is helpful to find problems in time and improve the quality of coated products.Traditional methods adopt...Film coating is an important unit operation to produce solid dosage forms,thereby,the monitoring of this process is helpful to find problems in time and improve the quality of coated products.Traditional methods adopted to monitor this process include measurement of coating weight gain,performance of disintegration and dissolution test,etc.However,not only do these methods cause destruction to the samples,but also consume time and energy.There have recently emerged the applications of process analytical technologies(PAT)on film coating,especially some novel spectroscopic and imaging technologies,which have the potential to real-time track the progress in film coating and optimize production efficiency.This article gives an overview on the application of such technologies for film coating,with the goal to provide a reference for the further researches.展开更多
Thirty-five fruits and seventeen vegetables from Martinique were evaluated for total phenol content (TPC), Vitamin C and carotenoid content. TPC, Vitamin C and carotenoid contents ranged from 11.7 to 978.6 mg/100g, 0....Thirty-five fruits and seventeen vegetables from Martinique were evaluated for total phenol content (TPC), Vitamin C and carotenoid content. TPC, Vitamin C and carotenoid contents ranged from 11.7 to 978.6 mg/100g, 0.1 to 2853.8 mg/100g and 9.7 to 9269.7 μg/100g respectively. Fruits and vegetables from Martinique have equivalent or higher TPC, Vitamin C and carotenoid contents than fruits and vegetables from temperate climates. Cashew apple had high values for all three parameters (55.8 mg/100g of Vitamin C, 603 mg/100g of TPC and 924 μg/100g of carotenoids). Bassignac mango and mamey apple had the highest carotenoid contents, with 3800.3 and 3199.7 μg/100g respectively. Acerola had the highest Vitamin C and polyphenol contents with 2853.8 μg/100g and 727.4 mg/100g respectively. Pigeon peas had high values for all three parameters (569.2 mg/100g of Vitamin C, 978.6 mg/100g of TPC and 364.3 μg/100g of carotenoids). Pumpkin and watercress had the highest carotenoid content, with 9269.7 and 4339 μg/100g respectively. TPC, Vitamin C and carotenoid content were significantly impacted by processing techniques. TPC, Vitamin C and carotenoid contents decreased by up to 75.78%, 100% and 70.18% respectively, depending on the processing technique used.展开更多
Nitrous gas is one of the chemicals often produced in adipic acid production, which will have a certain impact on the environment. Therefore, people attach importance to the production, and people's requirements f...Nitrous gas is one of the chemicals often produced in adipic acid production, which will have a certain impact on the environment. Therefore, people attach importance to the production, and people's requirements for quality of life are getting higher and higher with the development of economy. Therefore, in the development of chemical industry, we should pay attention to optimizing the air environment, including nitrous gas in common harmful chemical gases, which will have an impact on the air. To improve the overall air quality, we should be scientific and reasonable. This paper mainly analyzes the production of Jill acid and discusses the recovery of nitrite gas, hoping to bring help and reference to relevant personnel.展开更多
This paper focuses on the design of fixtures for NP2 and NP4 cylinder heads on a horizontal machining center of flexible machining automatic lines.It began with an analysis of the diagrams of part processing and worki...This paper focuses on the design of fixtures for NP2 and NP4 cylinder heads on a horizontal machining center of flexible machining automatic lines.It began with an analysis of the diagrams of part processing and working procedure which formed the basis for the design of the processing technology scheme,a selection of suitable machine tools,and the setting of processing parameters.Fixtures tailored to the chosen machine tools were then designed to meet the processing requirements.Additional aspects of the project included the design of part drawings,calculation of working time quota,design of auxiliary guides,support clamping,and hydraulic circuits,all aimed at fulfilling practical production requirements.展开更多
Developing trend and present situation on laser processing industry in China are mainly reviewed.The market analysis on laser processing systems are given,some new and rapidly developed laser processing systems are in...Developing trend and present situation on laser processing industry in China are mainly reviewed.The market analysis on laser processing systems are given,some new and rapidly developed laser processing systems are introduced.Finally,the paper also introduces some new kinds of laser systems and equipment.展开更多
基金supported by Ministry of Science and Technology of the People's Republic of China(Grant No.:2022YFC3502300)Beijing Natural Science Foundation(Grant No.:L222150)+2 种基金the National Natural Science Foundation of China(Grant No.:82072247)the second batch of“Ten thousand plan”National High Level Talents Special Support Plan(Grant No.:W02020052)Beijing University of Chinese Medicine(Grant Nos.:XJYS21005,JY21024,MSGZF-202001,2022-syjs-05,and 2022-syjs-10).
文摘The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.
文摘Highway is an important channel to connect regional economic development,and is an indispensable part of modern transportation system.In view of the extensive nature of highway cover space and the existence of diversified construction environment,climate and geological influence in highway construction,soft soil foundation is one of the more typical geological forms.With wide distribution in our country,seen as a big difficulty,highway construction technology and directly affect the quality of highway construction,cost,if not properly handled,will cause the soft soil foundation highway engineering structure is not stable,prone to accidents in use.In this paper,we study the treatment of soft soil foundation in highway construction,and put forward some reasonable Suggestions.
文摘With the advent of the big data era,real-time data analysis and decision-support systems have been recognized as essential tools for enhancing enterprise competitiveness and optimizing the decision-making process.This study aims to explore the development strategies of real-time data analysis and decision-support systems,and analyze their application status and future development trends in various industries.The article first reviews the basic concepts and importance of real-time data analysis and decision-support systems,and then discusses in detail the key technical aspects such as system architecture,data collection and processing,analysis methods,and visualization techniques.
文摘This article investigates the dynamic relationship between technology and AI(artificial intelligence)and the role that societal requirements play in pushing AI research and adoption.Technology has advanced dramatically throughout the years,providing the groundwork for the rise of AI.AI systems have achieved incredible feats in various disciplines thanks to advancements in computer power,data availability,and complex algorithms.On the other hand,society’s needs for efficiency,enhanced healthcare,environmental sustainability,and personalized experiences have worked as powerful accelerators for AI’s progress.This article digs into how technology empowers AI and how societal needs dictate its progress,emphasizing their symbiotic relationship.The findings underline the significance of responsible AI research,which considers both technological prowess and ethical issues,to ensure that AI continues to serve the greater good.
基金supported by National Natural Science Foundation of China(81202476)Medical Research Foundation of Guangdong Province(B2012079).
文摘Film coating is an important unit operation to produce solid dosage forms,thereby,the monitoring of this process is helpful to find problems in time and improve the quality of coated products.Traditional methods adopted to monitor this process include measurement of coating weight gain,performance of disintegration and dissolution test,etc.However,not only do these methods cause destruction to the samples,but also consume time and energy.There have recently emerged the applications of process analytical technologies(PAT)on film coating,especially some novel spectroscopic and imaging technologies,which have the potential to real-time track the progress in film coating and optimize production efficiency.This article gives an overview on the application of such technologies for film coating,with the goal to provide a reference for the further researches.
文摘Thirty-five fruits and seventeen vegetables from Martinique were evaluated for total phenol content (TPC), Vitamin C and carotenoid content. TPC, Vitamin C and carotenoid contents ranged from 11.7 to 978.6 mg/100g, 0.1 to 2853.8 mg/100g and 9.7 to 9269.7 μg/100g respectively. Fruits and vegetables from Martinique have equivalent or higher TPC, Vitamin C and carotenoid contents than fruits and vegetables from temperate climates. Cashew apple had high values for all three parameters (55.8 mg/100g of Vitamin C, 603 mg/100g of TPC and 924 μg/100g of carotenoids). Bassignac mango and mamey apple had the highest carotenoid contents, with 3800.3 and 3199.7 μg/100g respectively. Acerola had the highest Vitamin C and polyphenol contents with 2853.8 μg/100g and 727.4 mg/100g respectively. Pigeon peas had high values for all three parameters (569.2 mg/100g of Vitamin C, 978.6 mg/100g of TPC and 364.3 μg/100g of carotenoids). Pumpkin and watercress had the highest carotenoid content, with 9269.7 and 4339 μg/100g respectively. TPC, Vitamin C and carotenoid content were significantly impacted by processing techniques. TPC, Vitamin C and carotenoid contents decreased by up to 75.78%, 100% and 70.18% respectively, depending on the processing technique used.
文摘Nitrous gas is one of the chemicals often produced in adipic acid production, which will have a certain impact on the environment. Therefore, people attach importance to the production, and people's requirements for quality of life are getting higher and higher with the development of economy. Therefore, in the development of chemical industry, we should pay attention to optimizing the air environment, including nitrous gas in common harmful chemical gases, which will have an impact on the air. To improve the overall air quality, we should be scientific and reasonable. This paper mainly analyzes the production of Jill acid and discusses the recovery of nitrite gas, hoping to bring help and reference to relevant personnel.
文摘This paper focuses on the design of fixtures for NP2 and NP4 cylinder heads on a horizontal machining center of flexible machining automatic lines.It began with an analysis of the diagrams of part processing and working procedure which formed the basis for the design of the processing technology scheme,a selection of suitable machine tools,and the setting of processing parameters.Fixtures tailored to the chosen machine tools were then designed to meet the processing requirements.Additional aspects of the project included the design of part drawings,calculation of working time quota,design of auxiliary guides,support clamping,and hydraulic circuits,all aimed at fulfilling practical production requirements.
文摘Developing trend and present situation on laser processing industry in China are mainly reviewed.The market analysis on laser processing systems are given,some new and rapidly developed laser processing systems are introduced.Finally,the paper also introduces some new kinds of laser systems and equipment.
