Objectives:Checkpoint inhibitors have significantly improved outcomes in a number of malignancies.To determine the most effective course of treatment for head and neck squamous cell carcinoma(HNSCC),this systematic re...Objectives:Checkpoint inhibitors have significantly improved outcomes in a number of malignancies.To determine the most effective course of treatment for head and neck squamous cell carcinoma(HNSCC),this systematic review evaluated the efficacy of several therapeutic approaches based on immune checkpoint inhibitors(ICIs).Methods:A comprehensive evaluation of the literature was conducted,looking at randomized controlled trials(RCTs)that were published in Embase,PubMed,and the Cochrane Central Register of Controlled Trials since database establishment.The risk of bias of the enrolled studies was analyzed using The Review Manager(RevMan)5.4.Using network meta-analyses(NMA),the relative treatment effects on overall survival(OS)and progression-free survival(PFS)from qualifying randomized controlled trials were synthesized and evaluated.Results:Regarding OS,compared with nivolumab plus chemotherapy,chemotherapy(Hazard ratio(HR)2.1,95%Confidence interval=(CI):1.2,3.4)showed a treatment disadvantage.Meanwhile,nivolumab plus chemotherapy may represent the most efficient(57.89%)and has a lower cost among all the treatments enrolled in this study for advanced HNSCC.Regarding PFS,compared with nivolumab plus ipilimumab,nivolumab plus chemotherapy(HR 0.4,95%CI:0.2,0.8)showed=treatment superiority.Additionally,nivolumab plus chemotherapy(77.18%)has the longest PFS among all interventions.Conclusion:Taking into account OS and PFS,the combination of nivolumab plus chemotherapy may appear to be the most effective option and is associated with a comparatively lower cost among all treatments included in this network meta-analysis,thereby recommending its use as a first-line therapy for HNSCC.Registration:INPLASY(2024070073).展开更多
<b><span style="font-family:Verdana;">Introduction</span></b><span style="font-family:Verdana;">: According to the National Health and Nutrition Survey, the Mexican ho...<b><span style="font-family:Verdana;">Introduction</span></b><span style="font-family:Verdana;">: According to the National Health and Nutrition Survey, the Mexican households in 2018 had food insecurity at 55.5% while in 2012 it was 70%. Food insecurity is a global health problem and now with the COVID-19 pandemic</span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> it has increased. </span><b><span style="font-family:Verdana;">Objective</span></b><span style="font-family:Verdana;">: To compare the levels of food and nutritional insecurity in women’s households from two Social Impulse Centers of</span><span><span style="font-family:Verdana;"> the Secretary for Human Social Development (SEDESHU) before and during the COVID-19 pandemic. </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: A comparative a</span></span><span style="font-family:Verdana;">nd cross-sectional study was carried out in 41 women participating in a nutritional intervention program in two social promotion centers. Food security was measured with the Latin American and Caribbean Food Security Scale (ELCSA), comparing it in a period from January to April 2020: before and during the health contingency. Socio-economic and demographic variables were also measured, as well as access to water during the COVID-19 pandemic. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: Food insecurity levels during the COVID-19 contingency were found to have increased by more than 60% (from 31.7% to 93%);the main risk factors associated with unemployment and access to healthy food. The COVID-19 contingency reflects impacts on households, but because women participated in the nutritional intervention program, it could influence by observing that, at least, the use of food was adequate since apparently food waste was minimal. </span><b><span style="font-family:Verdana;">Conclusio</span><span style="font-family:Verdana;">n</span></b></span><b><span style="font-family:Verdana;">s</span></b><span style="font-family:Verdana;">: The implementation of an educational nutrition program can be a strateg</span><span style="font-family:Verdana;">y in the face of contingencies or extraordinary situations. In this way, the negative impact could be less in the population that does not have any type of food education.</span>展开更多
Coordinated partitioning and resource sharing have attracted considerable research interest in the field of real-time multiprocessor systems.However,finding an optimal partition is widely known as NP-hard,even for ind...Coordinated partitioning and resource sharing have attracted considerable research interest in the field of real-time multiprocessor systems.However,finding an optimal partition is widely known as NP-hard,even for independent tasks.A recently proposed resource-oriented partitioned(ROP)fixed-priority scheduling that partitions tasks and shared resources respectively has been shown to achieve a non-trivial speedup factor guarantee,which promotes the research of coordinated scheduling to a new level.Despite the theoretical elegance,the schedulability performance of ROP scheduling is restricted by the heuristic partitioning methods used in the original study.In this paper,we address the partitioning problem for tasks and shared resources under the ROP scheduling.A unified schedulability analysis framework for the ROP scheduling is proposed in the first place.A sophisticated partitioning approach based on integer linear programming(ILP)is then proposed based on the unified analysis.Empirical results show that the proposed methods improve the schedulability of ROP scheduling significantly,and the runtime complexity for searching a solution is reduced prominently compared with other ILP-based approaches as well.展开更多
文摘Objectives:Checkpoint inhibitors have significantly improved outcomes in a number of malignancies.To determine the most effective course of treatment for head and neck squamous cell carcinoma(HNSCC),this systematic review evaluated the efficacy of several therapeutic approaches based on immune checkpoint inhibitors(ICIs).Methods:A comprehensive evaluation of the literature was conducted,looking at randomized controlled trials(RCTs)that were published in Embase,PubMed,and the Cochrane Central Register of Controlled Trials since database establishment.The risk of bias of the enrolled studies was analyzed using The Review Manager(RevMan)5.4.Using network meta-analyses(NMA),the relative treatment effects on overall survival(OS)and progression-free survival(PFS)from qualifying randomized controlled trials were synthesized and evaluated.Results:Regarding OS,compared with nivolumab plus chemotherapy,chemotherapy(Hazard ratio(HR)2.1,95%Confidence interval=(CI):1.2,3.4)showed a treatment disadvantage.Meanwhile,nivolumab plus chemotherapy may represent the most efficient(57.89%)and has a lower cost among all the treatments enrolled in this study for advanced HNSCC.Regarding PFS,compared with nivolumab plus ipilimumab,nivolumab plus chemotherapy(HR 0.4,95%CI:0.2,0.8)showed=treatment superiority.Additionally,nivolumab plus chemotherapy(77.18%)has the longest PFS among all interventions.Conclusion:Taking into account OS and PFS,the combination of nivolumab plus chemotherapy may appear to be the most effective option and is associated with a comparatively lower cost among all treatments included in this network meta-analysis,thereby recommending its use as a first-line therapy for HNSCC.Registration:INPLASY(2024070073).
文摘<b><span style="font-family:Verdana;">Introduction</span></b><span style="font-family:Verdana;">: According to the National Health and Nutrition Survey, the Mexican households in 2018 had food insecurity at 55.5% while in 2012 it was 70%. Food insecurity is a global health problem and now with the COVID-19 pandemic</span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> it has increased. </span><b><span style="font-family:Verdana;">Objective</span></b><span style="font-family:Verdana;">: To compare the levels of food and nutritional insecurity in women’s households from two Social Impulse Centers of</span><span><span style="font-family:Verdana;"> the Secretary for Human Social Development (SEDESHU) before and during the COVID-19 pandemic. </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: A comparative a</span></span><span style="font-family:Verdana;">nd cross-sectional study was carried out in 41 women participating in a nutritional intervention program in two social promotion centers. Food security was measured with the Latin American and Caribbean Food Security Scale (ELCSA), comparing it in a period from January to April 2020: before and during the health contingency. Socio-economic and demographic variables were also measured, as well as access to water during the COVID-19 pandemic. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: Food insecurity levels during the COVID-19 contingency were found to have increased by more than 60% (from 31.7% to 93%);the main risk factors associated with unemployment and access to healthy food. The COVID-19 contingency reflects impacts on households, but because women participated in the nutritional intervention program, it could influence by observing that, at least, the use of food was adequate since apparently food waste was minimal. </span><b><span style="font-family:Verdana;">Conclusio</span><span style="font-family:Verdana;">n</span></b></span><b><span style="font-family:Verdana;">s</span></b><span style="font-family:Verdana;">: The implementation of an educational nutrition program can be a strateg</span><span style="font-family:Verdana;">y in the face of contingencies or extraordinary situations. In this way, the negative impact could be less in the population that does not have any type of food education.</span>
基金the National Natural Science Foundation of China under Grant Nos.61572112 and 61802052the Applied Basic Research Programs of Science and Technology Department in Sichuan Province of China under Grant No.2019YJ0185.
文摘Coordinated partitioning and resource sharing have attracted considerable research interest in the field of real-time multiprocessor systems.However,finding an optimal partition is widely known as NP-hard,even for independent tasks.A recently proposed resource-oriented partitioned(ROP)fixed-priority scheduling that partitions tasks and shared resources respectively has been shown to achieve a non-trivial speedup factor guarantee,which promotes the research of coordinated scheduling to a new level.Despite the theoretical elegance,the schedulability performance of ROP scheduling is restricted by the heuristic partitioning methods used in the original study.In this paper,we address the partitioning problem for tasks and shared resources under the ROP scheduling.A unified schedulability analysis framework for the ROP scheduling is proposed in the first place.A sophisticated partitioning approach based on integer linear programming(ILP)is then proposed based on the unified analysis.Empirical results show that the proposed methods improve the schedulability of ROP scheduling significantly,and the runtime complexity for searching a solution is reduced prominently compared with other ILP-based approaches as well.
