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Residential Community Open-Up Strategy Based on Prim’s Algorithm and Neural Network Algorithm
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作者 Ximing Lv Ang Li +1 位作者 Shunkai Zhang Jianbao Li 《Journal of Applied Mathematics and Physics》 2017年第2期551-567,共17页
“Open community” has aroused widespread concern and research. This paper focuses on the system analysis research of the problem that based on statistics including the regression equation fitting function and mathema... “Open community” has aroused widespread concern and research. This paper focuses on the system analysis research of the problem that based on statistics including the regression equation fitting function and mathematical theory, combined with the actual effect of camera measurement method, Prim’s algorithm and neural network to “Open community” and the applicable conditions. Research results show that with the increasing number of roads within the district, the benefit time gradually increased, but each type of district capacity is different. 展开更多
关键词 OPEN COMMUNITY Regression Analysis prim’s algorithm GRAPH Theory NEURAL Net-Work algorithm
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Applying Prim’s Algorithm to Identify Isolated Areas for Natural Disaster Prevention and Protection
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作者 Wen-Ching Wang Ming-Che Hsieh Chun-Hsiang Huang 《Engineering(科研)》 2018年第7期417-431,共15页
Based on the principle of “pre-disaster prevention outweighs rescue during disasters”, this study targets areas threatened by natural disasters, and develops an automatic algorithm based on the Prim algorithm to ser... Based on the principle of “pre-disaster prevention outweighs rescue during disasters”, this study targets areas threatened by natural disasters, and develops an automatic algorithm based on the Prim algorithm to serve as an automatic identification system. In the face of natural disasters that disable key facilities in the region and prevent settlements from contacting the outside world or outsiders from sending rescuers to the settlements, the proposed system helps to identify whether these regions will become isolated areas and conduct disaster mitigation and relief resource allocation before any natural disaster in order to reduce potential disaster losses. An automatic identification system, based on the threshold of channel blocking due to broken roads and bridges, determines through the decision tree model and relevant patterns whether such regions will become isolated areas by identifying areas based on the results of model analysis. The proposed system’s identification results are verified by actual case histories and comparisons;the results can be used to correctly identify isolated areas. Finally, Microsoft Visual Studio C # and Google Map are employed to apply the results and to produce an information mode for the determination and decision support of isolated areas affected by natural disasters. 展开更多
关键词 prim algorithm COMB ROUTE IsOLATION Area HAZARD DECIsION support system
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基于图像信息算法的2024年新疆乌什M_(S)7.1地震回溯性预测研究
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作者 袁伏全 黄浩 +2 位作者 徐玮阳 张晓清 刘兴盛 《地震研究》 北大核心 2026年第2期198-206,共9页
使用1970年以来新疆天山地震带及邻区的地震目录资料,基于图像信息(PI)算法,计算得到2016—2028年该地区逐年滑动的预测窗PI热点分布图像,并使用工作特征图表法(ROC)和R值评分法对PI算法的预测效能进行了检验。结果表明:①在2020—2024... 使用1970年以来新疆天山地震带及邻区的地震目录资料,基于图像信息(PI)算法,计算得到2016—2028年该地区逐年滑动的预测窗PI热点分布图像,并使用工作特征图表法(ROC)和R值评分法对PI算法的预测效能进行了检验。结果表明:①在2020—2024年回溯性预测图像中,2024年新疆乌什M_(S)7.1地震震中区域存在PI热点,具有较强的发震地点指示意义。②在5个回溯性预测时间窗(2016—2020年、2017—2021年、2018—2022年、2019—2023年、2020—2024年)内的PI热点图像演化过程中,乌什M_(S)7.1地震震中附近PI热点表现为“出现—逐步密集增强”,发震概率增大,该热点附近发震紧迫性和地震危险性增强。③ROC检验和R值评分显示,PI算法优于随机预测方法。④综合热点信息演化图像分析得到,南天山地震带的西南端强震危险性较高。 展开更多
关键词 乌什M_(s)7.1地震 PI算法 回溯性预测 地震热点 ROC检验
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Fast Mixture Distribution Optimization for Rain-Flow Matrix of a Steel Arch Bridge by REBMIX Algorithm
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作者 Yuliang He Weihong Lou +1 位作者 Da Hang Youhua Su 《Structural Durability & Health Monitoring》 2025年第4期887-902,共16页
The computational accuracy and efficiency of modeling the stress spectrum derived from bridge monitoring data significantly influence the fatigue life assessment of steel bridges.Therefore,determining the optimal stre... The computational accuracy and efficiency of modeling the stress spectrum derived from bridge monitoring data significantly influence the fatigue life assessment of steel bridges.Therefore,determining the optimal stress spectrum model is crucial for further fatigue reliability analysis.This study investigates the performance of the REBMIX algorithm in modeling both univariate(stress range)and multivariate(stress range and mean stress)distributions of the rain-flowmatrix for a steel arch bridge,usingAkaike’s Information Criterion(AIC)as a performance metric.Four types of finitemixture distributions—Normal,Lognormal,Weibull,and Gamma—are employed tomodel the stress range.Additionally,mixed distributions,including Normal-Normal,Lognormal-Normal,Weibull-Normal,and Gamma-Normal,are utilized to model the joint distribution of stress range and mean stress.The REBMIX algorithm estimates the number of components,component weights,and component parameters for each candidate finite mixture distribution.The results demonstrate that the REBMIX algorithm-based mixture parameter estimation approach effectively identifies the optimal distribution based on AIC values.Furthermore,the algorithm exhibits superior computational efficiency compared to traditional methods,making it highly suitable for practical applications. 展开更多
关键词 steel bridge stress spectrum finite mixture distribution REBMIX algorithm Akaike’s information criterion
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基于Prim算法的GIS连通性研究 被引量:5
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作者 马磊 李永树 《测绘科学》 CSCD 北大核心 2011年第6期204-206,共3页
通过分析传统的Prim算法及其数据结构与实现方法,本文提出了一种基于边存储结构和AE的改进Prim算法。改进算法优化并降低了原算法的时间复杂度与空间复杂度,提高了算法的运行效率,并应用于某城市交通网络的最优生成树(MST)的建立,实验... 通过分析传统的Prim算法及其数据结构与实现方法,本文提出了一种基于边存储结构和AE的改进Prim算法。改进算法优化并降低了原算法的时间复杂度与空间复杂度,提高了算法的运行效率,并应用于某城市交通网络的最优生成树(MST)的建立,实验分析证明了改进的算法更加适用于GIS海量数据的连通性分析与实现。 展开更多
关键词 prim算法 边存储结构 MsT 连通性
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基于prim和dijkstra组合算法的配电网新增容量规划方法 被引量:2
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作者 胡艺文 崔勇 +1 位作者 姬德森 陈伟 《中国农村水利水电》 北大核心 2015年第6期179-182,共4页
在城镇或农村配网用电增容的环境下,需要增容接入配电变压器,传统就近接入的简单方法有可能会导致配电网电能损耗增加,影响电网电压质量;由此研究了一种基于prim和dijkstra组合算法的配电网负荷接入方法。首先利用prim算法构造拟接入网... 在城镇或农村配网用电增容的环境下,需要增容接入配电变压器,传统就近接入的简单方法有可能会导致配电网电能损耗增加,影响电网电压质量;由此研究了一种基于prim和dijkstra组合算法的配电网负荷接入方法。首先利用prim算法构造拟接入网络的最小生成树,再运用改进的dijkstra算法得到拟接入负荷的次短路径和渐次短路径,同时统筹建设成本综合选出最优路径,用潮流计算验证网络节点电压是否合格;当电压不满足要求时,通过无功二次精确矩计算确定无功补偿点的位置和容量,以实现对电压偏差的修正,且保证配网运行的经济性。以IEEE57节点为实例计算及经济效果评价,验证了本方案的实用性。 展开更多
关键词 prim算法 DIJKsTRA算法 配网增容 无功二次精确矩
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Kruskal和Prim算法的分析研究与比较 被引量:3
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作者 贺军忠 王丽君 《陇东学院学报》 2020年第2期8-11,共4页
通过对Kruskal和Prim最小生成树算法的研究,分别从Kruskal和Prim算法的执行过程、时间复杂度、实现方法等几个方面对其进行分析,并对两种算法的实现方法做了合理性判断,由此得出了这两种算法在执行过程、时间复杂度和实现方法等方面的... 通过对Kruskal和Prim最小生成树算法的研究,分别从Kruskal和Prim算法的执行过程、时间复杂度、实现方法等几个方面对其进行分析,并对两种算法的实现方法做了合理性判断,由此得出了这两种算法在执行过程、时间复杂度和实现方法等方面的不同点,为最小生成树算法的选择提供了理论依据。 展开更多
关键词 Kruskal最小生成树算法 prim最小生成树算法 时间复杂度
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基于Prim算法和Kruskal算法的最小生成树优化研究 被引量:3
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作者 李仙玉 《计算机光盘软件与应用》 2010年第3期95-95,94,共2页
文章从目前最常见的两种在图最小生成树算法,即Prim和Kruskal算法,展开了阐述和分析,运用了大量的数据和实例对这两种计算方法进行了分析和研究。通过试验并对Prim算法进行改进,从图中每个顶点的度数入手,采取删除某些无用边的思... 文章从目前最常见的两种在图最小生成树算法,即Prim和Kruskal算法,展开了阐述和分析,运用了大量的数据和实例对这两种计算方法进行了分析和研究。通过试验并对Prim算法进行改进,从图中每个顶点的度数入手,采取删除某些无用边的思想方法,给出了一个寻找最小生成树的算法,使其能动态调整自身的性能,既适合于稠密图,又适合于稀疏图。 展开更多
关键词 prim算法 最小生成树 KRUsKAL算法
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改进的Prim启发式算法在VLSI布线中的应用 被引量:1
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作者 邓爱姣 李强 张嘉为 《沈阳工业大学学报》 EI CAS 2006年第5期557-559,567,共4页
总体布线在超大规模集成电路的设计中有着举足轻重的作用.为了寻求总体布线图的最优斯坦纳树,改进了普里姆(Prim)算法,提出了一种基于改进的普里姆启发式算法寻求最小矩形斯坦纳树(RST)的方法,不同于以往的先求最小生成树(MST)然后再把... 总体布线在超大规模集成电路的设计中有着举足轻重的作用.为了寻求总体布线图的最优斯坦纳树,改进了普里姆(Prim)算法,提出了一种基于改进的普里姆启发式算法寻求最小矩形斯坦纳树(RST)的方法,不同于以往的先求最小生成树(MST)然后再把树的边矩形化的方法;同时考虑到时延在深亚微米、超深亚微米阶段的重要影响,在算法中又加入了总体布线设计时的时延要求,最后通过仿真实例验证了算法的可行性. 展开更多
关键词 总体布线 总体布线图 改进的普里姆启发式算法 最小矩形斯坦纳树 时延
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基于正规基的大规模S盒FPGA设计与实现
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作者 张磊 李国元 +2 位作者 洪睿鹏 王建新 肖超恩 《密码学报(中英文)》 北大核心 2025年第4期854-869,共16页
传统上的分组密码S盒硬件实现采用查表法,其实现效果受到芯片资源的限制.针对16-bit大规模S盒在FPGA硬件实现中资源消耗大的问题,本文提出了基于复合域中正规基的S盒构造方法,研究使用较少的硬件资源实现16-bit S盒.首先,设计了基于复... 传统上的分组密码S盒硬件实现采用查表法,其实现效果受到芯片资源的限制.针对16-bit大规模S盒在FPGA硬件实现中资源消耗大的问题,本文提出了基于复合域中正规基的S盒构造方法,研究使用较少的硬件资源实现16-bit S盒.首先,设计了基于复合域的16-bit S盒构造实现方案,构建了线性的同构映射矩阵及其逆矩阵.其次,通过映射矩阵使有限域GF(2^(16))的乘法逆转换到复合域GF((((2^(2))^(2))^(2))^(2))上,进而将非线性的高维乘法逆简化为低维子域运算.然后,通过分析各级复合域不同参数对S盒实现的影响,筛选最优参数.最后,结合所提出的16-bit S盒构造实现框架,本文利用Xilinx公司的Vivado开发工具,以MK-3算法的16-bit S盒为例进行了FPGA仿真验证与性能分析.结果表明,本文构造方法实现的MK-3算法S盒需要186个LUT,时钟频率为114.129 MHz,在时钟频率/LUT的性能指标下达到了0.61360.同目前已公开文献同类方法中的最优实现性能0.43538相比,性能提升了40.93%.本文的16-bit S盒实现方案能够在降低硬件资源消耗的同时保持密码算法较高的运行频率,对有基于有限域构造的S盒的高效软硬件实现具有一定的参考价值. 展开更多
关键词 大规模s 复合域 正规基 MK-3算法 FPGA
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改进的Prim算法在GIS中的应用 被引量:4
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作者 杜玲玲 《测绘信息与工程》 2006年第1期28-29,共2页
探讨了数字常平基础信息平台建设项目中构建一个低造价通信网的问题,建立了网络模型和相应的存储结构,采用优化的Prim算法实现了这颗最小生成树。
关键词 地理信息系统 最小生成树 prim算法 低造价通信网
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Smooth constraint inversion technique in genetic algorithms and its application to surface wave study in the Tibetan Plateau 被引量:3
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作者 吴建平 明跃红 曾融生 《Acta Seismologica Sinica(English Edition)》 EI CSCD 2001年第1期49-57,共9页
Smooth constraint is important in linear inversion, but it is difficult to apply directly to model parameters in genetic algorithms. If the model parameters are smoothed in iteration, the diversity of models will be g... Smooth constraint is important in linear inversion, but it is difficult to apply directly to model parameters in genetic algorithms. If the model parameters are smoothed in iteration, the diversity of models will be greatly suppressed and all the models in population will tend to equal in a few iterations, so the optimal solution meeting requirement can not be obtained. In this paper, an indirect smooth constraint technique is introduced to genetic inversion. In this method, the new models produced in iteration are smoothed, then used as theoretical models in calculation of misfit function, but in process of iteration only the original models are used in order to keep the diversity of models. The technique is effective in inversion of surface wave and receiver function. Using this technique, we invert the phase velocity of Raleigh wave in the Tibetan Plateau, revealing the horizontal variation of S wave velocity structure near the center of the Tibetan Plateau. The results show that the S wave velocity in the north is relatively lower than that in the south. For most paths there is a lower velocity zone with 12-25 km thick at the depth of 15-40 km. The lower velocity zone in upper mantle is located below the depth of 100 km, and the thickness is usually 40-80 km, but for a few paths reach to 100 km thick. Among the area of Ando, Maqi and Ushu stations, there is an obvious lower velocity zone with the lowest velocity of 4.2-4.3 km/s at the depth of 90-230 km. Based on the S wave velocity structures of different paths and former data, we infer that the subduction of the Indian Plate is delimited nearby the Yarlung Zangbo suture zone. 展开更多
关键词 genetic algorithm smooth constraint surface wave s wave velocity structure Tibetan Plateau
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一种基于LEACH协议的WSN节能路由算法
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作者 黄艳红 《无线互联科技》 2025年第13期61-66,共6页
无线传感器网络(Wireless Sensor Network,WSN)存在路由复杂和能量有限的问题,对此,文章提出一种基于LEACH协议的改进路由算法I-LEACH(Improved LEACH)。该算法通过在每个簇内选出主、从2个簇首,分担簇内的数据能量消耗并在簇首间路由... 无线传感器网络(Wireless Sensor Network,WSN)存在路由复杂和能量有限的问题,对此,文章提出一种基于LEACH协议的改进路由算法I-LEACH(Improved LEACH)。该算法通过在每个簇内选出主、从2个簇首,分担簇内的数据能量消耗并在簇首间路由以代价函数选择中继节点,在簇内采用Prim改进算法生成多条链进行数据多跳通信。性能分析和仿真结果表明,该算法具有较好的节能性,能有效延长网络生存时间。 展开更多
关键词 无线传感器网络 LEACH协议 prim 节能路由算法
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A hybrid quantum encoding algorithm of vector quantization for image compression 被引量:4
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作者 庞朝阳 周正威 郭光灿 《Chinese Physics B》 SCIE EI CAS CSCD 2006年第12期3039-3043,共5页
Many classical encoding algorithms of vector quantization (VQ) of image compression that can obtain global optimal solution have computational complexity O(N). A pure quantum VQ encoding algorithm with probability... Many classical encoding algorithms of vector quantization (VQ) of image compression that can obtain global optimal solution have computational complexity O(N). A pure quantum VQ encoding algorithm with probability of success near 100% has been proposed, that performs operations 45√N times approximately. In this paper, a hybrid quantum VQ encoding algorithm between the classical method and the quantum algorithm is presented. The number of its operations is less than √N for most images, and it is more efficient than the pure quantum algorithm. 展开更多
关键词 vector quantization Grover's algorithm image compression quantum algorithm
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Hydraulic Optimization of a Double-channel Pump's Impeller Based on Multi-objective Genetic Algorithm 被引量:12
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作者 ZHAO Binjuan WANG Yu +2 位作者 CHEN Huilong QIU Jing HOU Duohua 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第3期634-640,共7页
Computational fluid dynamics(CFD) can give a lot of potentially very useful information for hydraulic optimization design of pumps, however, it cannot directly state what kind of modification should be made to impro... Computational fluid dynamics(CFD) can give a lot of potentially very useful information for hydraulic optimization design of pumps, however, it cannot directly state what kind of modification should be made to improve such hydrodynamic performance. In this paper, a more convenient and effective approach is proposed by combined using of CFD, multi-objective genetic algorithm(MOGA) and artificial neural networks(ANN) for a double-channel pump's impeller, with maximum head and efficiency set as optimization objectives, four key geometrical parameters including inlet diameter, outlet diameter, exit width and midline wrap angle chosen as optimization parameters. Firstly, a multi-fidelity fitness assignment system in which fitness of impellers serving as training and comparison samples for ANN is evaluated by CFD, meanwhile fitness of impellers generated by MOGA is evaluated by ANN, is established and dramatically reduces the computational expense. Then, a modified MOGA optimization process, in which selection is performed independently in two sub-populations according to two optimization objectives, crossover and mutation is performed afterword in the merged population, is developed to ensure the global optimal solution to be found. Finally, Pareto optimal frontier is found after 500 steps of iterations, and two optimal design schemes are chosen according to the design requirements. The preliminary and optimal design schemes are compared, and the comparing results show that hydraulic performances of both pumps 1 and 2 are improved, with the head and efficiency of pump 1 increased by 5.7% and 5.2%, respectively in the design working conditions, meanwhile shaft power decreased in all working conditions, the head and efficiency of pump 2 increased by 11.7% and 5.9%, respectively while shaft power increased by 5.5%. Inner flow field analyses also show that the backflow phenomenon significantly diminishes at the entrance of the optimal impellers 1 and 2, both the area of vortex and intensity of vortex decreases in the whole flow channel. This paper provides a promising tool to solve the hydraulic optimization problem of pumps' impellers. 展开更多
关键词 double-channel pump's impeller multi-objective genetic algorithm artificial neural network computational fluid dynamics(CFD) UNI
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Automatic Algorithm Programming Model Based on the Improved Morgan's Refinement Calculus 被引量:5
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作者 ZUO Zhengkang HU Ying +2 位作者 HUANG Qing WANG Yuan WANG Changjing 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2022年第5期405-414,共10页
The automatic algorithm programming model can increase the dependability and efficiency of algorithm program development,including specification generation,program refinement,and formal verification.However,the existi... The automatic algorithm programming model can increase the dependability and efficiency of algorithm program development,including specification generation,program refinement,and formal verification.However,the existing model has two flaws:incompleteness of program refinement and inadequate automation of formal verification.This paper proposes an automatic algorithm programming model based on the improved Morgan’s refinement calculus.It extends the Morgan’s refinement calculus rules and designs the C++generation system for realizing the complete process of refinement.Meanwhile,the automation tools VCG(Verification Condition Generator)and Isabelle are used to improve the automation of formal verification.An example of a stock’s maximum income demonstrates the effectiveness of the proposed model.Furthermore,the proposed model has some relevance for automatic software generation. 展开更多
关键词 automatic algorithm programming model program refinement VCG IsABELLE Morgan’s refinement calculus
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DETERMINING THE STRUCTURES AND PARAMETERS OF RADIAL BASIS FUNCTION NEURAL NETWORKS USING IMPROVED GENETIC ALGORITHMS 被引量:1
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作者 Meiqin Liu Jida Chen 《Journal of Central South University》 SCIE EI CAS 1998年第2期68-73,共6页
The method of determining the structures and parameters of radial basis function neural networks(RBFNNs) using improved genetic algorithms is proposed. Akaike′s information criterion (AIC) with generalization error t... The method of determining the structures and parameters of radial basis function neural networks(RBFNNs) using improved genetic algorithms is proposed. Akaike′s information criterion (AIC) with generalization error term is used as the best criterion of optimizing the structures and parameters of networks. It is shown from the simulation results that the method not only improves the approximation and generalization capability of RBFNNs ,but also obtain the optimal or suboptimal structures of networks. 展开更多
关键词 RADIAL BAsIs function neural network GENETIC algorithms Akaike′s information CRITERION OVERFITTING
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Image Segmentation of Brain MR Images Using Otsu’s Based Hybrid WCMFO Algorithm 被引量:6
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作者 A.Renugambal K.Selva Bhuvaneswari 《Computers, Materials & Continua》 SCIE EI 2020年第8期681-700,共20页
In this study,a novel hybrid Water Cycle Moth-Flame Optimization(WCMFO)algorithm is proposed for multilevel thresholding brain image segmentation in Magnetic Resonance(MR)image slices.WCMFO constitutes a hybrid betwee... In this study,a novel hybrid Water Cycle Moth-Flame Optimization(WCMFO)algorithm is proposed for multilevel thresholding brain image segmentation in Magnetic Resonance(MR)image slices.WCMFO constitutes a hybrid between the two techniques,comprising the water cycle and moth-flame optimization algorithms.The optimal thresholds are obtained by maximizing the between class variance(Otsu’s function)of the image.To test the performance of threshold searching process,the proposed algorithm has been evaluated on standard benchmark of ten axial T2-weighted brain MR images for image segmentation.The experimental outcomes infer that it produces better optimal threshold values at a greater and quicker convergence rate.In contrast to other state-of-the-art methods,namely Adaptive Wind Driven Optimization(AWDO),Adaptive Bacterial Foraging(ABF)and Particle Swarm Optimization(PSO),the proposed algorithm has been found to be better at producing the best objective function,Peak Signal-to-Noise Ratio(PSNR),Standard Deviation(STD)and lower computational time values.Further,it was observed thatthe segmented image gives greater detail when the threshold level increases.Moreover,the statistical test result confirms that the best and mean values are almost zero and the average difference between best and mean value 1.86 is obtained through the 30 executions of the proposed algorithm.Thus,these images will lead to better segments of gray,white and cerebrospinal fluid that enable better clinical choices and diagnoses using a proposed algorithm. 展开更多
关键词 Hybrid WCMFO algorithm Otsu’s function multilevel thresholding image segmentation brain MR image
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A quantum search algorithm of two entangled registers to realize quantum discrete Fourier transform of signal processing 被引量:2
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作者 庞朝阳 胡本琼 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第9期3220-3226,共7页
The discrete Fourier transform (DFT) is the base of modern signal processing. 1-dimensional fast Fourier transform (1D FFT) and 2D FFT have time complexity O(N log N) and O(N^2 log N) respectively. Since 1965,... The discrete Fourier transform (DFT) is the base of modern signal processing. 1-dimensional fast Fourier transform (1D FFT) and 2D FFT have time complexity O(N log N) and O(N^2 log N) respectively. Since 1965, there has been no more essential breakthrough for the design of fast DFT algorithm. DFT has two properties. One property is that DFT is energy conservation transform. The other property is that many DFT coefficients are close to zero. The basic idea of this paper is that the generalized Grover's iteration can perform the computation of DFT which acts on the entangled states to search the big DFT coefficients until these big coefficients contain nearly all energy. One-dimensional quantum DFT (1D QDFT) and two-dimensional quantum DFT (2D QDFT) are presented in this paper. The quantum algorithm for convolution estimation is also presented in this paper. Compared with FFT, 1D and 2D QDFT have time complexity O(v/N) and O(N) respectively. QDFT and quantum convolution demonstrate that quantum computation to process classical signal is possible. 展开更多
关键词 Grover's algorithm entangled state DFT QDFT
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Comparative analysis of various modularization algorithms and species specific study of VEGF signaling pathways 被引量:2
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作者 Namrata Tomar Losiana Nayak Rajat K. De 《Journal of Biomedical Science and Engineering》 2010年第10期931-942,共12页
In biology, signal transduction refers to a process by which a cell converts one kind of signal or stimulus into another. It involves ordered sequences of biochemical reactions inside the cell. These cascades of react... In biology, signal transduction refers to a process by which a cell converts one kind of signal or stimulus into another. It involves ordered sequences of biochemical reactions inside the cell. These cascades of reactions are carried out by enzymes and activated by second messengers. Signal transduction pathways are complex in nature. Each pathway is responsible for tuning one or more biological functions in the intracellular environment as well as more than one pathway interact among themselves to carry forward a single biological function. Such kind of behavior of these pathways makes understanding difficult. Hence, for the sake of simplicity, they need to be partitioned into smaller modules and then analyzed. We took VEGF signaling pathway, which is responsible for angiogenesis for this kind of modularized study. Modules were obtained by applying the algorithm of Nayak and De (Nayak and De, 2007) for different complexity values. These sets of modules were compared among themselves to get the best set of modules for an optimal complexity value. The best set of modules compared with four different partitioning algorithms namely, Farhat’s (Farhat, 1998), Greedy (Chartrand and Oellermann, 1993), Kernighan-Lin’s (Kernighan and Lin, 1970) and Newman’s community finding algorithm (Newman, 2006). These comparisons enabled us to decide which of the aforementioned algorithms was the best one to create partitions from human VEGF signaling pathway. The optimal complexity value, on which the best set of modules was obtained, was used to get modules from different species for comparative study. Comparison among these modules would shed light on the trend of development of VEGF signaling pathway over these species. 展开更多
关键词 signal TRANsDUCTION PATHWAY VEGF PATHWAY Complexity Value KEGG Database MODULARIZATION Newman’s Community Finding algorithm Kernighan-Lin’s algorithm Farhat’s algorithm and GREEDY algorithm.
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