Since the launch of a digitization project for the protection and utilization of ancient texts in the Sakya Monastery of the Xizang Autonomous Region in 2012,significant efforts and achievements have been made in anci...Since the launch of a digitization project for the protection and utilization of ancient texts in the Sakya Monastery of the Xizang Autonomous Region in 2012,significant efforts and achievements have been made in ancient text preservation.展开更多
Pseudosection modeling for the garnet amphibolite samples from the Western Dabie Mountains show they have experienced similar HP metamorphic evolution with that of the adjected eclogites.The common assemblage of
The most of high/ultrahigh-pressure(HP/UHP)terranes of the world are characterized by the occurrence of numerous pods,lenses or layered blocks of eclogite and amphibolites(e.g.O’Brien,1997;Elvevold and Gilotti,2000;Z...The most of high/ultrahigh-pressure(HP/UHP)terranes of the world are characterized by the occurrence of numerous pods,lenses or layered blocks of eclogite and amphibolites(e.g.O’Brien,1997;Elvevold and Gilotti,2000;Zhang et al.,2003;and references there in).Field and petrological features suggest that amphibolites should展开更多
Apples,as respiratory climacteric fruit,undergo postharvest ripening and senescence,impacting commodity value.Cuticular wax protects against environmental stresses.Here,gas chromatography-mass spectrometry(GC-MS)analy...Apples,as respiratory climacteric fruit,undergo postharvest ripening and senescence,impacting commodity value.Cuticular wax protects against environmental stresses.Here,gas chromatography-mass spectrometry(GC-MS)analysis revealed a decline in fatty alcohol levels in apple wax during storage,correlating with fruit quality deterioration.Notably,octacosanol content signifcantly decreased with storage,suggesting that it is a primary cause of wax and fruit quality decline.Octacosanol treatment improved fruit quality and delayed softening by enhancing wax synthesis and antioxidant levels and suppressing cell wall-degrading enzymes.Transcriptome sequencing and real-time quantitative polymerase chain reaction(RT-qPCR)assays indicated increased expression of wax,peroxidase,sucrose,and starch genes and decreased expression of cell wall degradation genes,explaining octacosanol’s benefts.This study provides a theoretical basis for octacosanol application in fruit preservation.展开更多
Chinese-German sculptor Zhou Xiaoping has been traveling between China and Germany,creating sculptures,since 2003.She has created more than 80 large,urban sculptures,each of which has become a vivid carrier of urban m...Chinese-German sculptor Zhou Xiaoping has been traveling between China and Germany,creating sculptures,since 2003.She has created more than 80 large,urban sculptures,each of which has become a vivid carrier of urban memories.During the past decade,she has focused on creating freeform sculptures,and she has launched a global,cross-disciplinary-artist-collaboration project,which has involved the preservation of archives for contemporary artistic creation.展开更多
This study addresses the risk of privacy leakage during the transmission and sharing of multimodal data in smart grid substations by proposing a three-tier privacy-preserving architecture based on asynchronous federat...This study addresses the risk of privacy leakage during the transmission and sharing of multimodal data in smart grid substations by proposing a three-tier privacy-preserving architecture based on asynchronous federated learning.The framework integrates blockchain technology,the InterPlanetary File System(IPFS)for distributed storage,and a dynamic differential privacy mechanism to achieve collaborative security across the storage,service,and federated coordination layers.It accommodates both multimodal data classification and object detection tasks,enabling the identification and localization of key targets and abnormal behaviors in substation scenarios while ensuring privacy protection.This effectively mitigates the single-point failures and model leakage issues inherent in centralized architectures.A dynamically adjustable differential privacy mechanism is introduced to allocate privacy budgets according to client contribution levels and upload frequencies,achieving a personalized balance between model performance and privacy protection.Multi-dimensional experimental evaluations,including classification accuracy,F1-score,encryption latency,and aggregation latency,verify the security and efficiency of the proposed architecture.The improved CNN model achieves 72.34%accuracy and an F1-score of 0.72 in object detection and classification tasks on infrared surveillance imagery,effectively identifying typical risk events such as not wearing safety helmets and unauthorized intrusion,while maintaining an aggregation latency of only 1.58 s and a query latency of 80.79 ms.Compared with traditional static differential privacy and centralized approaches,the proposed method demonstrates significant advantages in accuracy,latency,and security,providing a new technical paradigm for efficient,secure data sharing,object detection,and privacy preservation in smart grid substations.展开更多
Chinese abbreviations improve communicative efficiency by extracting key components from longer expressions.They are widely used in both daily communication and professional domains.However,existing abbreviation gener...Chinese abbreviations improve communicative efficiency by extracting key components from longer expressions.They are widely used in both daily communication and professional domains.However,existing abbreviation generation methods still face two major challenges.First,sequence-labeling-based approaches often neglect contextual meaning by making binary decisions at the character level,leading to abbreviations that fail to capture semantic completeness.Second,generation-basedmethods rely heavily on a single decoding process,which frequently produces correct abbreviations but ranks them lower due to inadequate semantic evaluation.To address these limitations,we propose a novel two-stage frameworkwithGeneration–Iterative Optimization forAbbreviation(GIOA).In the first stage,we design aChain-of-Thought prompting strategy and incorporate definitional and situational contexts to generate multiple abbreviation candidates.In the second stage,we introduce a Semantic Preservation Dynamic Adjustment mechanism that alternates between character-level importance estimation and semantic restoration to optimize candidate ranking.Experiments on two public benchmark datasets show that our method outperforms existing state-of-the-art approaches,achieving Hit@1 improvements of 15.15%and 13.01%,respectively,while maintaining consistent results in Hit@3.展开更多
With the rapid expansion of drone applications,accurate detection of objects in aerial imagery has become crucial for intelligent transportation,urban management,and emergency rescue missions.However,existing methods ...With the rapid expansion of drone applications,accurate detection of objects in aerial imagery has become crucial for intelligent transportation,urban management,and emergency rescue missions.However,existing methods face numerous challenges in practical deployment,including scale variation handling,feature degradation,and complex backgrounds.To address these issues,we propose Edge-enhanced and Detail-Capturing You Only Look Once(EHDC-YOLO),a novel framework for object detection in Unmanned Aerial Vehicle(UAV)imagery.Based on the You Only Look Once version 11 nano(YOLOv11n)baseline,EHDC-YOLO systematically introduces several architectural enhancements:(1)a Multi-Scale Edge Enhancement(MSEE)module that leverages multi-scale pooling and edge information to enhance boundary feature extraction;(2)an Enhanced Feature Pyramid Network(EFPN)that integrates P2-level features with Cross Stage Partial(CSP)structures and OmniKernel convolutions for better fine-grained representation;and(3)Dynamic Head(DyHead)with multi-dimensional attention mechanisms for enhanced cross-scale modeling and perspective adaptability.Comprehensive experiments on the Vision meets Drones for Detection(VisDrone-DET)2019 dataset demonstrate that EHDC-YOLO achieves significant improvements,increasing mean Average Precision(mAP)@0.5 from 33.2%to 46.1%(an absolute improvement of 12.9 percentage points)and mAP@0.5:0.95 from 19.5%to 28.0%(an absolute improvement of 8.5 percentage points)compared with the YOLOv11n baseline,while maintaining a reasonable parameter count(2.81 M vs the baseline’s 2.58 M).Further ablation studies confirm the effectiveness of each proposed component,while visualization results highlight EHDC-YOLO’s superior performance in detecting objects and handling occlusions in complex drone scenarios.展开更多
Background:Ex vivo lung perfusion(EVLP)has emerged as a critical technique for lung preservation and evaluation prior to transplantation.While conventional rat EVLP systems utilize closed-loop dual cannulation of pulm...Background:Ex vivo lung perfusion(EVLP)has emerged as a critical technique for lung preservation and evaluation prior to transplantation.While conventional rat EVLP systems utilize closed-loop dual cannulation of pulmonary artery(PA)and vein,the effect of the simplified model using single PA cannulation with passive venous drainage is unknown.Methods:We developed two EVLP models in rats:a semi-closed circuit with PA-only cannulation and left atrial incision for passive venous drainage(SC-EVLP),and a closed circuit employing both arterial and venous cannulation(C-EVLP).Donor lungs were perfused for a defined duration and subsequently orthotopically transplanted.We evaluated pulmonary function parameters,histopathological injury scores,inflammatory cytokine levels,and apoptotic marker expression at the end of perfusion and posttransplantation.Results:Compared to the conventional EVLP,the SC-EVLP group exhibited significantly lower PA pressure and improved dynamic lung compliance throughout perfusion.Although the levels of tumor necrosis factor-αin the perfusate were higher in the SC-EVLP group,other cytokine levels in the perfusate and bronchoalveolar lavage fluid exhibited no significant differences.Pulmonary edema was reduced in the SC-EVLP group,as indicated by a lower lung wet-to-dry ratio.After transplantation,lungs from the SC-EVLP group exhibited lower histological injury scores,reduced apoptosis,and decreased serum cytokine levels,suggesting attenuated inflammation and tissue damage.Conclusions:In a rat model,single PA cannulation with passive venous drainage reduced pulmonary edema during EVLP and reduced lung injury and systemic inflammation after transplantation.展开更多
The Nuo mask is the core visual vehicle within China’s Nuo culture and constitutes a complex symbolic system through facial features(icons),patterns(indexes),and colors(symbols).Within the context of intangible cultu...The Nuo mask is the core visual vehicle within China’s Nuo culture and constitutes a complex symbolic system through facial features(icons),patterns(indexes),and colors(symbols).Within the context of intangible cultural heritage(ICH)preservation,its value lies in the continuation and revitalization of its dynamic symbolic functions.Grounded in semiotic theory,this paper elaborates on three core dimensions of symbolic value manifested by Nuo masks in ICH preservation:a ritual symbol for living transmission,a symbol of identity for collective memory,and an aesthetic symbol as a source of creativity.展开更多
Background:Locally advanced laryngeal squamous cell carcinoma(LA-LSCC)presents clinical challenges due to the lack of reliable non-invasive biomarkers.This study aimed to evaluate miR-449a as a diagnostic and prognost...Background:Locally advanced laryngeal squamous cell carcinoma(LA-LSCC)presents clinical challenges due to the lack of reliable non-invasive biomarkers.This study aimed to evaluate miR-449a as a diagnostic and prognostic biomarker in LA-LSCC.Methods:miR-449a expression was analyzed in tumor tissues,adjacent normal tissues,and serum from 81 LA-LSCC patients and 50 controls using quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR).We assessed the diagnostic accuracy by Receiver Operating Characteristic curve(ROC curves),clinicopathological associations,survival outcomes(Kaplan-Meier),and treatment response dynamics.Results:miR-449a was significantly downregulated in LA-LSCC tissues(p<0.0001)and serum(p<0.0001),with a strong tissue-serum correlation(R^(2)=0.988).Tissue miR-449a demonstrated a diagnostic accuracy(Area Under the Curve,AUC=0.857),while serum showed moderate accuracy(AUC=0.734).High miR-449a expression correlated with favorable clinicopathological features and improved survival(median overall survival:67.82 vs.23.74 months;p=0.0012).Multivariate analysis confirmed miR-449a as an independent prognostic factor(p<0.001).miR-449a levels increased post-treatment,particularly in responders to chemotherapy/radiation(p<0.0001).Conclusion:miR-449a serves as a non-invasive biomarker for LA-LSCC diagnosis,prognosis,and treatment monitoring.Its dynamic expression highlights potential for risk stratification and therapy response prediction,warranting further validation in larger cohorts.展开更多
Wuyuan Bay marina is the rising star as a yachting sports and leisure center in Xiamen City, southeast China’s Fujian Province. China (Xiamen) International Boat Show 2011 was held between
RNA methylation on N6-methyladenosine(m6A)and histone methylation are critical mechanisms regulating gene expression at epitranscriptomic and epigenetic levels,respectively.However,how RNA methylation modulates histon...RNA methylation on N6-methyladenosine(m6A)and histone methylation are critical mechanisms regulating gene expression at epitranscriptomic and epigenetic levels,respectively.However,how RNA methylation modulates histone methylation,and in which biological processes,is unknown.In a recent study published in Nature,Liu et al.1 identified the critical roles of m6A and its reader YTHDC1 in mediating histone methylation and chromatin silencing of retrotransposon genes to preserve embryonic stem(ES)cell identity.展开更多
Microtubules(MTs)are cytoskeletal filaments composed of polarized arrays of globularα/β-tubulin dimers organized as hollow cylinders.Thanks to this arrangement,MTs are mechanically rigid and can assemble into large ...Microtubules(MTs)are cytoskeletal filaments composed of polarized arrays of globularα/β-tubulin dimers organized as hollow cylinders.Thanks to this arrangement,MTs are mechanically rigid and can assemble into large intracellular structures that serve diverse cellular functions.In dividing cells,MTs organize bipolar mitotic spindles,ensuring equal segregation of sister chromatids and cor-rect placement of daughter cells into the tissue(Gudimchuk and McIntosh,2021;Lechler and Mapelli,2021).展开更多
Publisher Correction:aBIOTECH https://doi.org/10.1007/s42994-024-00149-5 The original article has been updated to correct two errors introduced during production:In this article Xiu Li the same as Mingzhuo Li and Guol...Publisher Correction:aBIOTECH https://doi.org/10.1007/s42994-024-00149-5 The original article has been updated to correct two errors introduced during production:In this article Xiu Li the same as Mingzhuo Li and Guoliang Ma should have been denoted as equally contributing authors.展开更多
Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate a...Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate anatomy of the root canal system,instrument-related factors,and instrumentation techniques.Instrument separation can hinder thorough cleaning,shaping,and obturation of the root canal,posing challenges to successful treatment outcomes.Although retrieval of separated instrument is often feasible,it carries risks including perforation,excessive removal of tooth structure and root fractures.Effective management of separated instruments requires a comprehensive understanding of the contributing factors,meticulous preoperative assessment,and precise evaluation of the retrieval difficulty.The application of appropriate retrieval techniques is essential to minimize complications and optimize clinical outcomes.The current manuscript provides a framework for understanding the causes,risk factors,and clinical management principles of instrument separation.By integrating effective strategies,endodontists can enhance decision-making,improve endodontic treatment success and ensure the preservation of natural dentition.展开更多
In addition to the organic matter type,abundance,thermal maturity,and shale reservoir space,the preservation conditions of source rocks play a key factor in affecting the quantity and quality of retained hydrocarbons ...In addition to the organic matter type,abundance,thermal maturity,and shale reservoir space,the preservation conditions of source rocks play a key factor in affecting the quantity and quality of retained hydrocarbons in source rocks of lacustrine shale,yet this aspect has received little attention.This paper,based on the case analysis,explores how preservation conditions influence the enrichment of mobile hydrocarbons in shale oil.Research showns that good preservation conditions play three key roles.(1)Ensure the retention of sufficient light hydrocarbons(C_(1)–C_(13)),medium hydrocarbons(C_(14)–C_(25))and small molecular aromatics(including 1–2 benzene rings)in the formation,which enhances the fluidity and flow of shale oil;(2)Maintain a high energy field(abnormally high pressure),thus facilitating the maximum outflow of shale oil;(3)Ensure that the retained hydrocarbons have the miscible flow condition of multi-component hydrocarbons(light hydrocarbons,medium hydrocarbons,heavy hydrocarbons,and heteroatomic compounds),so that the heavy hydrocarbons(C_(25+))and heavy components(non-hydrocarbons and asphaltenes)have improved fluidity and maximum flow capacity.In conclusion,in addition to the advantages of organic matter type,abundance,thermal maturity,and reservoir space,good preservation conditions of shale layers are essential for the formation of economically viable shale oil reservoirs,which should be incorporated into the evaluation criteria of shale oil-rich areas/segments and considered a necessary factor when selecting favorable exploration targets.展开更多
The spatiotemporal characterization of plume sedimentation and microorganisms is critical for developing plume ecological monitoring model.To address the limitations of traditional methods in obtaining high-quality se...The spatiotemporal characterization of plume sedimentation and microorganisms is critical for developing plume ecological monitoring model.To address the limitations of traditional methods in obtaining high-quality sediment,a novel sampling system with 6000 m operational capability and three-month endurance was developed.It is equipped with three sediment samplers,a set of formaldehyde preservation solution injection devices.The system is controlled by a low-power,timing-triggered controllers.To investigate low-disturbance rheological mechanisms,gap controlled rheological tests were conducted to optimize the structural design of the sampling and sealing assembly.Stress-controlled shear rheological tests were employed to investigate the mechanisms governing yield stress in sediments under varying temperature conditions and boundary roughness.Additionally,the coupled Eulerian-Lagrangian(CEL)method and sediment rheological constitutive models were employed to simulate tube-soil interaction dynamics and sediment disturbance.The radial heterogeneity of sediment disturbance and friction variation of the sampling tube were revealed.The tube was completely“plugged”at a penetration depth of 261 mm,providing critical data support to the penetration depth parameters.The deep-sea pressure test and South China Sea field trials demonstrated the system’s capability to collect and preserve quantitative time-series sediment samples with high fidelity.展开更多
Occurrence and abundance of molecular hydrogen in natural geologic reservoirs are enigmatic,due to its various sources,diverse migration pathways and complicated biological and chemical reactions.Natural gas samples c...Occurrence and abundance of molecular hydrogen in natural geologic reservoirs are enigmatic,due to its various sources,diverse migration pathways and complicated biological and chemical reactions.Natural gas samples containing hydrogen from producing wells in several sedimentary basins in China were collected in this study,and gas abundances and isotopic compositions of these gases were compared with those in global petroliferous basins and deep intrusive rocks.Several geochemical indicators were suggested for identifying sources,migration and accumulation mechanisms of hydrogen in the subsurface environment.Hydrogen contents in natural gas deposits have contributions from various sources with the following high-to-low order:microbial degradation>serpentinization>deep mantle volatile release>radiation-induced water decomposition>thermal cracking of organic matter.A hydrogen-rich reservoir in Kansas,USA,is specifically analyzed to determine its formation mechanism.This study suggests that future exploration of geological hydrogen resources may focus on the igneous rock bodies with overlying dense sedimentary rocks in the continental rift systems.展开更多
The heritage preservation is of great intractability to the conservators as each kind of heritage material has unique and diverse requirements on temperature,humidity and air cleanliness.It is promising for metal-orga...The heritage preservation is of great intractability to the conservators as each kind of heritage material has unique and diverse requirements on temperature,humidity and air cleanliness.It is promising for metal-organic frameworks(MOFs),the multifunctional environment remediation materials,to be applied in heritage environmental protection.The advantages of MOFs lie in their multifunction like adsorption,photocatalysis,sterilization,as well as the controllable structure and properties that could be flexibly adjusted as demands,helping the heritage against various environmental threats.Thereby,the applications and the corresponding mechanisms of MOFs in cultural heritage preservation were reviewed in this work,including harmful gas adsorption,surface waterproofing,particulate matters(PM)removal,anti-bacterial and humidity control of environment.Finally,the selection principles and precautions of MOFs in heritage preservation were discussed,aiming to provide a forward-looking direction for the selection and application of MOFs.展开更多
文摘Since the launch of a digitization project for the protection and utilization of ancient texts in the Sakya Monastery of the Xizang Autonomous Region in 2012,significant efforts and achievements have been made in ancient text preservation.
文摘Pseudosection modeling for the garnet amphibolite samples from the Western Dabie Mountains show they have experienced similar HP metamorphic evolution with that of the adjected eclogites.The common assemblage of
文摘The most of high/ultrahigh-pressure(HP/UHP)terranes of the world are characterized by the occurrence of numerous pods,lenses or layered blocks of eclogite and amphibolites(e.g.O’Brien,1997;Elvevold and Gilotti,2000;Zhang et al.,2003;and references there in).Field and petrological features suggest that amphibolites should
基金supported by the grants from the National Key Research and Development Program of China(Nos.2023YFD2301000 and 2022YFD2100102)the National Natural Science Foundation of China(Nos.32122080 and 32302616)+2 种基金the Key Research and Development Program of Shandong Province,China(No.2023CXGC010709)the Natural Science Foundation of Shandong Province,China(No.ZR2023QC032)the National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops,China(No.Horti-KF-2023-11).
文摘Apples,as respiratory climacteric fruit,undergo postharvest ripening and senescence,impacting commodity value.Cuticular wax protects against environmental stresses.Here,gas chromatography-mass spectrometry(GC-MS)analysis revealed a decline in fatty alcohol levels in apple wax during storage,correlating with fruit quality deterioration.Notably,octacosanol content signifcantly decreased with storage,suggesting that it is a primary cause of wax and fruit quality decline.Octacosanol treatment improved fruit quality and delayed softening by enhancing wax synthesis and antioxidant levels and suppressing cell wall-degrading enzymes.Transcriptome sequencing and real-time quantitative polymerase chain reaction(RT-qPCR)assays indicated increased expression of wax,peroxidase,sucrose,and starch genes and decreased expression of cell wall degradation genes,explaining octacosanol’s benefts.This study provides a theoretical basis for octacosanol application in fruit preservation.
文摘Chinese-German sculptor Zhou Xiaoping has been traveling between China and Germany,creating sculptures,since 2003.She has created more than 80 large,urban sculptures,each of which has become a vivid carrier of urban memories.During the past decade,she has focused on creating freeform sculptures,and she has launched a global,cross-disciplinary-artist-collaboration project,which has involved the preservation of archives for contemporary artistic creation.
基金funded by the National Natural Science Foundation of China,grant number 61605004the Fundamental Research Funds for the Central Universities,grant number FRF-TP-19-016A2Guizhou Power Grid Co.,Ltd.2024 first batch of services(2024-2026 technology R&D services for science and technology projects(in addition to national and SGCC key projects)),grant number 060100KC23100012。
文摘This study addresses the risk of privacy leakage during the transmission and sharing of multimodal data in smart grid substations by proposing a three-tier privacy-preserving architecture based on asynchronous federated learning.The framework integrates blockchain technology,the InterPlanetary File System(IPFS)for distributed storage,and a dynamic differential privacy mechanism to achieve collaborative security across the storage,service,and federated coordination layers.It accommodates both multimodal data classification and object detection tasks,enabling the identification and localization of key targets and abnormal behaviors in substation scenarios while ensuring privacy protection.This effectively mitigates the single-point failures and model leakage issues inherent in centralized architectures.A dynamically adjustable differential privacy mechanism is introduced to allocate privacy budgets according to client contribution levels and upload frequencies,achieving a personalized balance between model performance and privacy protection.Multi-dimensional experimental evaluations,including classification accuracy,F1-score,encryption latency,and aggregation latency,verify the security and efficiency of the proposed architecture.The improved CNN model achieves 72.34%accuracy and an F1-score of 0.72 in object detection and classification tasks on infrared surveillance imagery,effectively identifying typical risk events such as not wearing safety helmets and unauthorized intrusion,while maintaining an aggregation latency of only 1.58 s and a query latency of 80.79 ms.Compared with traditional static differential privacy and centralized approaches,the proposed method demonstrates significant advantages in accuracy,latency,and security,providing a new technical paradigm for efficient,secure data sharing,object detection,and privacy preservation in smart grid substations.
基金supported by the National Key Research and Development Program of China(2020AAA0109300)the Shanghai Collaborative Innovation Center of data intelligence technology(No.0232-A1-8900-24-13).
文摘Chinese abbreviations improve communicative efficiency by extracting key components from longer expressions.They are widely used in both daily communication and professional domains.However,existing abbreviation generation methods still face two major challenges.First,sequence-labeling-based approaches often neglect contextual meaning by making binary decisions at the character level,leading to abbreviations that fail to capture semantic completeness.Second,generation-basedmethods rely heavily on a single decoding process,which frequently produces correct abbreviations but ranks them lower due to inadequate semantic evaluation.To address these limitations,we propose a novel two-stage frameworkwithGeneration–Iterative Optimization forAbbreviation(GIOA).In the first stage,we design aChain-of-Thought prompting strategy and incorporate definitional and situational contexts to generate multiple abbreviation candidates.In the second stage,we introduce a Semantic Preservation Dynamic Adjustment mechanism that alternates between character-level importance estimation and semantic restoration to optimize candidate ranking.Experiments on two public benchmark datasets show that our method outperforms existing state-of-the-art approaches,achieving Hit@1 improvements of 15.15%and 13.01%,respectively,while maintaining consistent results in Hit@3.
文摘With the rapid expansion of drone applications,accurate detection of objects in aerial imagery has become crucial for intelligent transportation,urban management,and emergency rescue missions.However,existing methods face numerous challenges in practical deployment,including scale variation handling,feature degradation,and complex backgrounds.To address these issues,we propose Edge-enhanced and Detail-Capturing You Only Look Once(EHDC-YOLO),a novel framework for object detection in Unmanned Aerial Vehicle(UAV)imagery.Based on the You Only Look Once version 11 nano(YOLOv11n)baseline,EHDC-YOLO systematically introduces several architectural enhancements:(1)a Multi-Scale Edge Enhancement(MSEE)module that leverages multi-scale pooling and edge information to enhance boundary feature extraction;(2)an Enhanced Feature Pyramid Network(EFPN)that integrates P2-level features with Cross Stage Partial(CSP)structures and OmniKernel convolutions for better fine-grained representation;and(3)Dynamic Head(DyHead)with multi-dimensional attention mechanisms for enhanced cross-scale modeling and perspective adaptability.Comprehensive experiments on the Vision meets Drones for Detection(VisDrone-DET)2019 dataset demonstrate that EHDC-YOLO achieves significant improvements,increasing mean Average Precision(mAP)@0.5 from 33.2%to 46.1%(an absolute improvement of 12.9 percentage points)and mAP@0.5:0.95 from 19.5%to 28.0%(an absolute improvement of 8.5 percentage points)compared with the YOLOv11n baseline,while maintaining a reasonable parameter count(2.81 M vs the baseline’s 2.58 M).Further ablation studies confirm the effectiveness of each proposed component,while visualization results highlight EHDC-YOLO’s superior performance in detecting objects and handling occlusions in complex drone scenarios.
基金Key Science and Technology Program of Shaanxi Province,Grant/Award Number:2024SF2-GJHX-45National Natural Science Foundation of China,Grant/Award Number:82472191The Natural Science Foundation of Shaanxi Province,Grant/Award Number:2024JC-ZDXM-49。
文摘Background:Ex vivo lung perfusion(EVLP)has emerged as a critical technique for lung preservation and evaluation prior to transplantation.While conventional rat EVLP systems utilize closed-loop dual cannulation of pulmonary artery(PA)and vein,the effect of the simplified model using single PA cannulation with passive venous drainage is unknown.Methods:We developed two EVLP models in rats:a semi-closed circuit with PA-only cannulation and left atrial incision for passive venous drainage(SC-EVLP),and a closed circuit employing both arterial and venous cannulation(C-EVLP).Donor lungs were perfused for a defined duration and subsequently orthotopically transplanted.We evaluated pulmonary function parameters,histopathological injury scores,inflammatory cytokine levels,and apoptotic marker expression at the end of perfusion and posttransplantation.Results:Compared to the conventional EVLP,the SC-EVLP group exhibited significantly lower PA pressure and improved dynamic lung compliance throughout perfusion.Although the levels of tumor necrosis factor-αin the perfusate were higher in the SC-EVLP group,other cytokine levels in the perfusate and bronchoalveolar lavage fluid exhibited no significant differences.Pulmonary edema was reduced in the SC-EVLP group,as indicated by a lower lung wet-to-dry ratio.After transplantation,lungs from the SC-EVLP group exhibited lower histological injury scores,reduced apoptosis,and decreased serum cytokine levels,suggesting attenuated inflammation and tissue damage.Conclusions:In a rat model,single PA cannulation with passive venous drainage reduced pulmonary edema during EVLP and reduced lung injury and systemic inflammation after transplantation.
基金National Social Science Fund project“Research on the Narrative of the Sense of Community for the Chinese Nation in Southwest Nuo Opera”(24XMZ063).
文摘The Nuo mask is the core visual vehicle within China’s Nuo culture and constitutes a complex symbolic system through facial features(icons),patterns(indexes),and colors(symbols).Within the context of intangible cultural heritage(ICH)preservation,its value lies in the continuation and revitalization of its dynamic symbolic functions.Grounded in semiotic theory,this paper elaborates on three core dimensions of symbolic value manifested by Nuo masks in ICH preservation:a ritual symbol for living transmission,a symbol of identity for collective memory,and an aesthetic symbol as a source of creativity.
基金The authors extend their appreciation to Taif University,Saudi Arabia,for supporting this work through project No.(TU-DSPP-2024-54).
文摘Background:Locally advanced laryngeal squamous cell carcinoma(LA-LSCC)presents clinical challenges due to the lack of reliable non-invasive biomarkers.This study aimed to evaluate miR-449a as a diagnostic and prognostic biomarker in LA-LSCC.Methods:miR-449a expression was analyzed in tumor tissues,adjacent normal tissues,and serum from 81 LA-LSCC patients and 50 controls using quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR).We assessed the diagnostic accuracy by Receiver Operating Characteristic curve(ROC curves),clinicopathological associations,survival outcomes(Kaplan-Meier),and treatment response dynamics.Results:miR-449a was significantly downregulated in LA-LSCC tissues(p<0.0001)and serum(p<0.0001),with a strong tissue-serum correlation(R^(2)=0.988).Tissue miR-449a demonstrated a diagnostic accuracy(Area Under the Curve,AUC=0.857),while serum showed moderate accuracy(AUC=0.734).High miR-449a expression correlated with favorable clinicopathological features and improved survival(median overall survival:67.82 vs.23.74 months;p=0.0012).Multivariate analysis confirmed miR-449a as an independent prognostic factor(p<0.001).miR-449a levels increased post-treatment,particularly in responders to chemotherapy/radiation(p<0.0001).Conclusion:miR-449a serves as a non-invasive biomarker for LA-LSCC diagnosis,prognosis,and treatment monitoring.Its dynamic expression highlights potential for risk stratification and therapy response prediction,warranting further validation in larger cohorts.
文摘Wuyuan Bay marina is the rising star as a yachting sports and leisure center in Xiamen City, southeast China’s Fujian Province. China (Xiamen) International Boat Show 2011 was held between
文摘RNA methylation on N6-methyladenosine(m6A)and histone methylation are critical mechanisms regulating gene expression at epitranscriptomic and epigenetic levels,respectively.However,how RNA methylation modulates histone methylation,and in which biological processes,is unknown.In a recent study published in Nature,Liu et al.1 identified the critical roles of m6A and its reader YTHDC1 in mediating histone methylation and chromatin silencing of retrotransposon genes to preserve embryonic stem(ES)cell identity.
文摘Microtubules(MTs)are cytoskeletal filaments composed of polarized arrays of globularα/β-tubulin dimers organized as hollow cylinders.Thanks to this arrangement,MTs are mechanically rigid and can assemble into large intracellular structures that serve diverse cellular functions.In dividing cells,MTs organize bipolar mitotic spindles,ensuring equal segregation of sister chromatids and cor-rect placement of daughter cells into the tissue(Gudimchuk and McIntosh,2021;Lechler and Mapelli,2021).
文摘Publisher Correction:aBIOTECH https://doi.org/10.1007/s42994-024-00149-5 The original article has been updated to correct two errors introduced during production:In this article Xiu Li the same as Mingzhuo Li and Guoliang Ma should have been denoted as equally contributing authors.
文摘Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate anatomy of the root canal system,instrument-related factors,and instrumentation techniques.Instrument separation can hinder thorough cleaning,shaping,and obturation of the root canal,posing challenges to successful treatment outcomes.Although retrieval of separated instrument is often feasible,it carries risks including perforation,excessive removal of tooth structure and root fractures.Effective management of separated instruments requires a comprehensive understanding of the contributing factors,meticulous preoperative assessment,and precise evaluation of the retrieval difficulty.The application of appropriate retrieval techniques is essential to minimize complications and optimize clinical outcomes.The current manuscript provides a framework for understanding the causes,risk factors,and clinical management principles of instrument separation.By integrating effective strategies,endodontists can enhance decision-making,improve endodontic treatment success and ensure the preservation of natural dentition.
基金Supported by the National Natural Science Foundation of China(U22B6004)Project of PetroChina Research Institute of Petroleum Exploration and Development(2022yjcq03)Core Technology Key Project of China Petroleum Changqing Oilfield Company(KJZX2023-01).
文摘In addition to the organic matter type,abundance,thermal maturity,and shale reservoir space,the preservation conditions of source rocks play a key factor in affecting the quantity and quality of retained hydrocarbons in source rocks of lacustrine shale,yet this aspect has received little attention.This paper,based on the case analysis,explores how preservation conditions influence the enrichment of mobile hydrocarbons in shale oil.Research showns that good preservation conditions play three key roles.(1)Ensure the retention of sufficient light hydrocarbons(C_(1)–C_(13)),medium hydrocarbons(C_(14)–C_(25))and small molecular aromatics(including 1–2 benzene rings)in the formation,which enhances the fluidity and flow of shale oil;(2)Maintain a high energy field(abnormally high pressure),thus facilitating the maximum outflow of shale oil;(3)Ensure that the retained hydrocarbons have the miscible flow condition of multi-component hydrocarbons(light hydrocarbons,medium hydrocarbons,heavy hydrocarbons,and heteroatomic compounds),so that the heavy hydrocarbons(C_(25+))and heavy components(non-hydrocarbons and asphaltenes)have improved fluidity and maximum flow capacity.In conclusion,in addition to the advantages of organic matter type,abundance,thermal maturity,and reservoir space,good preservation conditions of shale layers are essential for the formation of economically viable shale oil reservoirs,which should be incorporated into the evaluation criteria of shale oil-rich areas/segments and considered a necessary factor when selecting favorable exploration targets.
基金supported by the National Key R&D Program of China(No.2022YFC2803900)the National Natural Science Foundation of China(No.42276191)Zhejiang University Students Science and Technology Innovation Activity Plan(New Talent Plan)(No.2024R401185).
文摘The spatiotemporal characterization of plume sedimentation and microorganisms is critical for developing plume ecological monitoring model.To address the limitations of traditional methods in obtaining high-quality sediment,a novel sampling system with 6000 m operational capability and three-month endurance was developed.It is equipped with three sediment samplers,a set of formaldehyde preservation solution injection devices.The system is controlled by a low-power,timing-triggered controllers.To investigate low-disturbance rheological mechanisms,gap controlled rheological tests were conducted to optimize the structural design of the sampling and sealing assembly.Stress-controlled shear rheological tests were employed to investigate the mechanisms governing yield stress in sediments under varying temperature conditions and boundary roughness.Additionally,the coupled Eulerian-Lagrangian(CEL)method and sediment rheological constitutive models were employed to simulate tube-soil interaction dynamics and sediment disturbance.The radial heterogeneity of sediment disturbance and friction variation of the sampling tube were revealed.The tube was completely“plugged”at a penetration depth of 261 mm,providing critical data support to the penetration depth parameters.The deep-sea pressure test and South China Sea field trials demonstrated the system’s capability to collect and preserve quantitative time-series sediment samples with high fidelity.
基金supported by the National Natural Science Foundation of China(Nos.42488101,42141021,42172149,42172168,U2244209)the Tencent Foundation through the XPLORER PRIZE。
文摘Occurrence and abundance of molecular hydrogen in natural geologic reservoirs are enigmatic,due to its various sources,diverse migration pathways and complicated biological and chemical reactions.Natural gas samples containing hydrogen from producing wells in several sedimentary basins in China were collected in this study,and gas abundances and isotopic compositions of these gases were compared with those in global petroliferous basins and deep intrusive rocks.Several geochemical indicators were suggested for identifying sources,migration and accumulation mechanisms of hydrogen in the subsurface environment.Hydrogen contents in natural gas deposits have contributions from various sources with the following high-to-low order:microbial degradation>serpentinization>deep mantle volatile release>radiation-induced water decomposition>thermal cracking of organic matter.A hydrogen-rich reservoir in Kansas,USA,is specifically analyzed to determine its formation mechanism.This study suggests that future exploration of geological hydrogen resources may focus on the igneous rock bodies with overlying dense sedimentary rocks in the continental rift systems.
基金supported by the National Natural Science Foundation of China(Nos.52308300,52370025,52108266).
文摘The heritage preservation is of great intractability to the conservators as each kind of heritage material has unique and diverse requirements on temperature,humidity and air cleanliness.It is promising for metal-organic frameworks(MOFs),the multifunctional environment remediation materials,to be applied in heritage environmental protection.The advantages of MOFs lie in their multifunction like adsorption,photocatalysis,sterilization,as well as the controllable structure and properties that could be flexibly adjusted as demands,helping the heritage against various environmental threats.Thereby,the applications and the corresponding mechanisms of MOFs in cultural heritage preservation were reviewed in this work,including harmful gas adsorption,surface waterproofing,particulate matters(PM)removal,anti-bacterial and humidity control of environment.Finally,the selection principles and precautions of MOFs in heritage preservation were discussed,aiming to provide a forward-looking direction for the selection and application of MOFs.
