英语阅读教学在高中英语教学中占有非常重要的地位,但当前高中英语阅读教学中困难多多,英语阅读互动教学的设计与开发能有助于解决教学困境。本文在分析互动教学软件制作途径的基础上,推介了Adobe Presenter这一适用于高中英语教师开发...英语阅读教学在高中英语教学中占有非常重要的地位,但当前高中英语阅读教学中困难多多,英语阅读互动教学的设计与开发能有助于解决教学困境。本文在分析互动教学软件制作途径的基础上,推介了Adobe Presenter这一适用于高中英语教师开发互动教学内容的教学软件,并结合高中英语第三模块第一单元的＂Festivals around the World＂,具体分析了基于Adobe Presenter的英语阅读互动教学软件的开发。展开更多
The introduction of the ICTs （Information and Communication Technologies） in education has set a new paradigm in knowledge acquisition. The Internet, overhead projectors and interactive boards, presentation and anim...The introduction of the ICTs （Information and Communication Technologies） in education has set a new paradigm in knowledge acquisition. The Internet, overhead projectors and interactive boards, presentation and animation software, and online databases are only some resources that teachers use in order to present information in a more dynamic, immediate, and stunning way, transforming and revitalizing the teaching-learning process. The ICTs have been established in the university classroom and nowadays, they have become an essential part in this teaching-learning process. Lecturers make use of them in the same proportion as they make of traditional materials. At the same time, students have to be acquainted with these new technologies and they also have to be able to deal with them. The objective of this paper is twofold： On the one hand, we study and show how our students make use of the technologies when they have to face their oral presentations in the subject Advanced English： Professional Settings （English Studies Degree at Universitat Jaume I in Castellen, Spain）. It is acknowledged that visual aids can be helpful to support a speech, but we want to analyze if the visual aids are successfully applied, how and to which extent. On the other hand, we want to make out the opinions of their classmates about the use of these graphical resources （students fill in a questionnaire about the effectiveness of the visual aids in their classmates＇ presentations and how they would improve them）. Results demonstrate that not only teachers make advantage of the new technological resources, we show, based on the students＇ oral presentations and their peer-reviews, that also our university students are increasingly aware of the advantage and importance of the ICTs in the classroom.展开更多
Being able to convey the nuances of each culture constitutes the true meaning of cultural exchanges.INTERPRETER,talk show performer,presenter,and art dealer.Li Song,born in the 1980s in Shanghai,wears many hats.Whethe...Being able to convey the nuances of each culture constitutes the true meaning of cultural exchanges.INTERPRETER,talk show performer,presenter,and art dealer.Li Song,born in the 1980s in Shanghai,wears many hats.Whether on the stage,television set,or at a Sino-French activity,most likely,this dynamic man will be there.展开更多
Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectiv...Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system.展开更多
Immunization has long played essential roles in preventing diseases.However,the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet.Here,we describe the use of acupoint de...Immunization has long played essential roles in preventing diseases.However,the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet.Here,we describe the use of acupoint delivery of nanovaccines(ADN)to elicit dual-niche immunological priming.ADN can simultaneously stimulate mast cell-assisted maturation of dendritic cells at the acupoint and enable direct delivery of nanovaccines into the draining lymph nodes.We demonstrate that ADN not only provokes antigen presentation by lymph node-resident CD8α^(+)dendritic cells,but also induces the accumulation of nanovaccines in B-cell zones,amplifying antigen-specific cytotoxic T lymphocyte responses and immunoglobulin G antibody expression in draining lymph nodes.ADN also generates systemic immune responses by causing immune memory and preventing T-cell anergy in the spleen.Further supported by evoking effective antitumor responses and high-level antiviral antibodies in mice,ADN provides a simple yet versatile platform for advanced nanovaccination.展开更多
Mycobacterium tuberculosis(Mtb)employs multiple mechanisms,such as phagocytosis and autophagy,to evade innate immune clearance and establish infection.In the present study,we identified the ESX-1 secretion-associated ...Mycobacterium tuberculosis(Mtb)employs multiple mechanisms,such as phagocytosis and autophagy,to evade innate immune clearance and establish infection.In the present study,we identified the ESX-1 secretion-associated protein EspL,which promotes Mtb survival by inhibiting phagosome maturation and autophagy initiation.EspL knockout decreased Mtb intracellular survival,while EspL overexpression increased bacterial survival by interfering with phagocytosis and autophagy.EspL interacts with ULK1 and promotes its phosphorylation at Ser^(757),leading to the inhibition of autophagy initiation.Additionally,overexpression of EspL reduced antigen presentation and T-cell responses both in vitro and in vivo.Our findings revealed that EspL interferes with autophagy and antigen presenta-tion by suppressing ULK1 activation.These insights provide a novel understanding of Mtb pathogenicity.展开更多
BACKGROUND Groove pancreatitis(GP)is a rare focal chronic pancreatitis of the pancreaticoduodenal groove that is usually diagnosed in chronic alcoholics.However,it is often difficult to differentiate from pancreatic o...BACKGROUND Groove pancreatitis(GP)is a rare focal chronic pancreatitis of the pancreaticoduodenal groove that is usually diagnosed in chronic alcoholics.However,it is often difficult to differentiate from pancreatic or periampullary cancers.In this study,we report a case of GP with the rare symptom of severe gastric outlet obstruction.CASE SUMMARY A 68-year-old man presented to our institution with severe gastric outlet obstruction accompanied by vomiting persisted for 3 days,severe electrolyte imbalance,and altered mental status with cardiac arrest.Differential diagnosis of cancers of the ampulla of Vater or duodenum was difficult due to discordant findings from preoperative imaging and an endoscopic biopsy of the lesion.In addition,the gastric outlet obstruction did not improve with conservative treatment;therefore,pancreatoduodenectomy was performed.Postoperatively,the histological findings revealed multiple cystic lesions in the duodenal wall that were collectively diagnosed as GP.The patient underwent a follow-up 3 years postoperatively and was found to have no postoperative sequelae.CONCLUSION In this case of GP,pancreatoduodenectomy safely treated severe gastric outlet obstruction when a cancer diagnosis could not be excluded.展开更多
Introduction: Crohn’s Disease (CD) is a chronic inflammatory disorder with a heterogeneous presentation. While diarrhea, abdominal pain, and weight loss are hallmarks, atypical manifestations can obscure the diagnosi...Introduction: Crohn’s Disease (CD) is a chronic inflammatory disorder with a heterogeneous presentation. While diarrhea, abdominal pain, and weight loss are hallmarks, atypical manifestations can obscure the diagnosis. This report highlights an unusual presentation of CD to emphasize the need for comprehensive diagnostic strategies. Case Report: A 25-year-old male presented with peripheral edema, anorexia, and abdominal distension but lacked classic gastrointestinal (GI) symptoms. Laboratory findings included microcytic anemia and hypoalbuminemia, while imaging revealed ascites and bowel wall thickening. Elevated fecal calprotectin and positive Anti-Saccharomyces cerevisiae antibodies (ASCA) supported the diagnosis. Endoscopy confirmed ileocolic Crohn’s Disease (L3 + L4). Infliximab therapy resulted in marked clinical improvement. Discussion: This case underscores the complexity of atypical CD presentations. Early use of serological markers, imaging, and endoscopy guided the diagnosis. Recognition of CD’s diverse manifestations is critical for timely intervention. Conclusion: Atypical CD presentations require heightened clinical suspicion and a multidisciplinary approach to reduce diagnostic delays and improve patient outcomes.展开更多
The Third International Conference on Rail Transportation(ICRT),which was initiated by Southwest Jiaotong University and hosted by Tongji University,took place successfully in Shanghai,China,from August 7 to 9,2024.As...The Third International Conference on Rail Transportation(ICRT),which was initiated by Southwest Jiaotong University and hosted by Tongji University,took place successfully in Shanghai,China,from August 7 to 9,2024.As the chairman of the ICRT conference,I am delighted to witness its remarkable achievement.Based on the success of previous editions held in Chengdu in 2017 and 2021,this conference aims to provide a premier platform for extensive interaction and collaboration among universities,research institutions,and enterprises worldwide.展开更多
The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming...The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming at the theme on“Sharing Academic Ideas&Promoting Innovation for Development”.The forum will feature world-class speakers,academic panels,and discussions.The Forum co-chairs invite the submission of original papers for presentation.展开更多
The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming...The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming at the theme on“Sharing Academic Ideas&Promoting Innovation for Development”.The forum will feature world-class speakers,academic panels,and discussions.The Forum co-chairs invite the submission of original papers for presentation.展开更多
The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming...The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming at the theme on“Sharing Academic Ideas&Promoting Innovation for Development”.The forum will feature world-class speakers,academic panels,and discussions.The Forum co-chairs invite the submission of original papers for presentation.展开更多
文摘英语阅读教学在高中英语教学中占有非常重要的地位,但当前高中英语阅读教学中困难多多,英语阅读互动教学的设计与开发能有助于解决教学困境。本文在分析互动教学软件制作途径的基础上,推介了Adobe Presenter这一适用于高中英语教师开发互动教学内容的教学软件,并结合高中英语第三模块第一单元的＂Festivals around the World＂,具体分析了基于Adobe Presenter的英语阅读互动教学软件的开发。
文摘The introduction of the ICTs （Information and Communication Technologies） in education has set a new paradigm in knowledge acquisition. The Internet, overhead projectors and interactive boards, presentation and animation software, and online databases are only some resources that teachers use in order to present information in a more dynamic, immediate, and stunning way, transforming and revitalizing the teaching-learning process. The ICTs have been established in the university classroom and nowadays, they have become an essential part in this teaching-learning process. Lecturers make use of them in the same proportion as they make of traditional materials. At the same time, students have to be acquainted with these new technologies and they also have to be able to deal with them. The objective of this paper is twofold： On the one hand, we study and show how our students make use of the technologies when they have to face their oral presentations in the subject Advanced English： Professional Settings （English Studies Degree at Universitat Jaume I in Castellen, Spain）. It is acknowledged that visual aids can be helpful to support a speech, but we want to analyze if the visual aids are successfully applied, how and to which extent. On the other hand, we want to make out the opinions of their classmates about the use of these graphical resources （students fill in a questionnaire about the effectiveness of the visual aids in their classmates＇ presentations and how they would improve them）. Results demonstrate that not only teachers make advantage of the new technological resources, we show, based on the students＇ oral presentations and their peer-reviews, that also our university students are increasingly aware of the advantage and importance of the ICTs in the classroom.
文摘Being able to convey the nuances of each culture constitutes the true meaning of cultural exchanges.INTERPRETER,talk show performer,presenter,and art dealer.Li Song,born in the 1980s in Shanghai,wears many hats.Whether on the stage,television set,or at a Sino-French activity,most likely,this dynamic man will be there.
基金supported in part by the National Natural Science Foundation of China(62173255,62188101)Shenzhen Key Laboratory of Control Theory and Intelligent Systems(ZDSYS20220330161800001)
文摘Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system.
基金supported by the National Key Research and Development Program of China(2021YFA0909400)the National Natural Science Foundation of China(22425505,32301099,and 21834007)+2 种基金the Shanghai Sailing Program(22YF1424200)the Interdisciplinary Program of Shanghai Jiao Tong University(YG2022QN032)the Xiangfu Lab Research Project(XF012022E0100).
文摘Immunization has long played essential roles in preventing diseases.However,the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet.Here,we describe the use of acupoint delivery of nanovaccines(ADN)to elicit dual-niche immunological priming.ADN can simultaneously stimulate mast cell-assisted maturation of dendritic cells at the acupoint and enable direct delivery of nanovaccines into the draining lymph nodes.We demonstrate that ADN not only provokes antigen presentation by lymph node-resident CD8α^(+)dendritic cells,but also induces the accumulation of nanovaccines in B-cell zones,amplifying antigen-specific cytotoxic T lymphocyte responses and immunoglobulin G antibody expression in draining lymph nodes.ADN also generates systemic immune responses by causing immune memory and preventing T-cell anergy in the spleen.Further supported by evoking effective antitumor responses and high-level antiviral antibodies in mice,ADN provides a simple yet versatile platform for advanced nanovaccination.
基金supported by the National Natural Science Foundation of China under grant number U21A20259the National Key Research and Development Program of China under grant number 2021YFD1800401.
文摘Mycobacterium tuberculosis(Mtb)employs multiple mechanisms,such as phagocytosis and autophagy,to evade innate immune clearance and establish infection.In the present study,we identified the ESX-1 secretion-associated protein EspL,which promotes Mtb survival by inhibiting phagosome maturation and autophagy initiation.EspL knockout decreased Mtb intracellular survival,while EspL overexpression increased bacterial survival by interfering with phagocytosis and autophagy.EspL interacts with ULK1 and promotes its phosphorylation at Ser^(757),leading to the inhibition of autophagy initiation.Additionally,overexpression of EspL reduced antigen presentation and T-cell responses both in vitro and in vivo.Our findings revealed that EspL interferes with autophagy and antigen presenta-tion by suppressing ULK1 activation.These insights provide a novel understanding of Mtb pathogenicity.
文摘BACKGROUND Groove pancreatitis(GP)is a rare focal chronic pancreatitis of the pancreaticoduodenal groove that is usually diagnosed in chronic alcoholics.However,it is often difficult to differentiate from pancreatic or periampullary cancers.In this study,we report a case of GP with the rare symptom of severe gastric outlet obstruction.CASE SUMMARY A 68-year-old man presented to our institution with severe gastric outlet obstruction accompanied by vomiting persisted for 3 days,severe electrolyte imbalance,and altered mental status with cardiac arrest.Differential diagnosis of cancers of the ampulla of Vater or duodenum was difficult due to discordant findings from preoperative imaging and an endoscopic biopsy of the lesion.In addition,the gastric outlet obstruction did not improve with conservative treatment;therefore,pancreatoduodenectomy was performed.Postoperatively,the histological findings revealed multiple cystic lesions in the duodenal wall that were collectively diagnosed as GP.The patient underwent a follow-up 3 years postoperatively and was found to have no postoperative sequelae.CONCLUSION In this case of GP,pancreatoduodenectomy safely treated severe gastric outlet obstruction when a cancer diagnosis could not be excluded.
文摘Introduction: Crohn’s Disease (CD) is a chronic inflammatory disorder with a heterogeneous presentation. While diarrhea, abdominal pain, and weight loss are hallmarks, atypical manifestations can obscure the diagnosis. This report highlights an unusual presentation of CD to emphasize the need for comprehensive diagnostic strategies. Case Report: A 25-year-old male presented with peripheral edema, anorexia, and abdominal distension but lacked classic gastrointestinal (GI) symptoms. Laboratory findings included microcytic anemia and hypoalbuminemia, while imaging revealed ascites and bowel wall thickening. Elevated fecal calprotectin and positive Anti-Saccharomyces cerevisiae antibodies (ASCA) supported the diagnosis. Endoscopy confirmed ileocolic Crohn’s Disease (L3 + L4). Infliximab therapy resulted in marked clinical improvement. Discussion: This case underscores the complexity of atypical CD presentations. Early use of serological markers, imaging, and endoscopy guided the diagnosis. Recognition of CD’s diverse manifestations is critical for timely intervention. Conclusion: Atypical CD presentations require heightened clinical suspicion and a multidisciplinary approach to reduce diagnostic delays and improve patient outcomes.
文摘The Third International Conference on Rail Transportation(ICRT),which was initiated by Southwest Jiaotong University and hosted by Tongji University,took place successfully in Shanghai,China,from August 7 to 9,2024.As the chairman of the ICRT conference,I am delighted to witness its remarkable achievement.Based on the success of previous editions held in Chengdu in 2017 and 2021,this conference aims to provide a premier platform for extensive interaction and collaboration among universities,research institutions,and enterprises worldwide.
文摘The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming at the theme on“Sharing Academic Ideas&Promoting Innovation for Development”.The forum will feature world-class speakers,academic panels,and discussions.The Forum co-chairs invite the submission of original papers for presentation.
文摘The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming at the theme on“Sharing Academic Ideas&Promoting Innovation for Development”.The forum will feature world-class speakers,academic panels,and discussions.The Forum co-chairs invite the submission of original papers for presentation.
文摘The 2025 CIC Blue Ocean Forum for Worldwide Scientists,sponsored by the China Institute of Communications and organized by China Communications Editorial Office,will be held at the beginning of August this year,aiming at the theme on“Sharing Academic Ideas&Promoting Innovation for Development”.The forum will feature world-class speakers,academic panels,and discussions.The Forum co-chairs invite the submission of original papers for presentation.
