Iron-sulfur(Fe-S)proteins are among the most common type of natural metalloproteins that participate in a large range of key metabolic processes.To date,enormous research works on the exploration of protein structures...Iron-sulfur(Fe-S)proteins are among the most common type of natural metalloproteins that participate in a large range of key metabolic processes.To date,enormous research works on the exploration of protein structures and catalytic mechanisms have revealed that the active sites are generally composed of a Fe-S cluster and a highly conserved coordination environment.Accordingly,people are enlightened by the prebiotic evolution of an-cient clusters and are dedicated to the development of biosynthetic methods for modern clusters.This review aims to systemically summarize the structural development of peptide-coordinated iron-sulfur clusters from two perspectives:"bottom-up"approaches involving evolution of prebiotic chemical synthesis for natural proteins and"top-down"analyses of biosynthesis in modern biological systems for artificial metalloproteins.Moreover,current challenges and the direction of future development are also presented to provide new perspectives of developing enzyme mimics and further mechanistic studies.展开更多
This paper presents in a concise way the main characteristics of life from the physical point of view and the most successful theories of biogenesis, together with a mathematical formulation and simulation of proto-bi...This paper presents in a concise way the main characteristics of life from the physical point of view and the most successful theories of biogenesis, together with a mathematical formulation and simulation of proto-biogenesis. We present here a calculation method for biochemical reactions based on the available reaction data base, and using this method, we calculate precise scenarios for the first life cycle, and for the first stages of terrestrial biological evolution.展开更多
文摘Iron-sulfur(Fe-S)proteins are among the most common type of natural metalloproteins that participate in a large range of key metabolic processes.To date,enormous research works on the exploration of protein structures and catalytic mechanisms have revealed that the active sites are generally composed of a Fe-S cluster and a highly conserved coordination environment.Accordingly,people are enlightened by the prebiotic evolution of an-cient clusters and are dedicated to the development of biosynthetic methods for modern clusters.This review aims to systemically summarize the structural development of peptide-coordinated iron-sulfur clusters from two perspectives:"bottom-up"approaches involving evolution of prebiotic chemical synthesis for natural proteins and"top-down"analyses of biosynthesis in modern biological systems for artificial metalloproteins.Moreover,current challenges and the direction of future development are also presented to provide new perspectives of developing enzyme mimics and further mechanistic studies.
文摘This paper presents in a concise way the main characteristics of life from the physical point of view and the most successful theories of biogenesis, together with a mathematical formulation and simulation of proto-biogenesis. We present here a calculation method for biochemical reactions based on the available reaction data base, and using this method, we calculate precise scenarios for the first life cycle, and for the first stages of terrestrial biological evolution.
