Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across vari...Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across various domains.However,the deployment of such models in resource-constrained environments presents a unique set of challenges that require innovative solutions.Resource-constrained environments encompass scenarios where computing resources,memory,and energy availability are restricted.To empower sentiment analysis in resource-constrained environments,we address the crucial need by leveraging lightweight pre-trained models.These models,derived from popular architectures such as DistilBERT,MobileBERT,ALBERT,TinyBERT,ELECTRA,and SqueezeBERT,offer a promising solution to the resource limitations imposed by these environments.By distilling the knowledge from larger models into smaller ones and employing various optimization techniques,these lightweight models aim to strike a balance between performance and resource efficiency.This paper endeavors to explore the performance of multiple lightweight pre-trained models in sentiment analysis tasks specific to such environments and provide insights into their viability for practical deployment.展开更多
Pneumonia is an acute lung infection that has caused many fatalitiesglobally. Radiologists often employ chest X-rays to identify pneumoniasince they are presently the most effective imaging method for this purpose.Com...Pneumonia is an acute lung infection that has caused many fatalitiesglobally. Radiologists often employ chest X-rays to identify pneumoniasince they are presently the most effective imaging method for this purpose.Computer-aided diagnosis of pneumonia using deep learning techniques iswidely used due to its effectiveness and performance. In the proposed method,the Synthetic Minority Oversampling Technique (SMOTE) approach is usedto eliminate the class imbalance in the X-ray dataset. To compensate forthe paucity of accessible data, pre-trained transfer learning is used, and anensemble Convolutional Neural Network (CNN) model is developed. Theensemble model consists of all possible combinations of the MobileNetv2,Visual Geometry Group (VGG16), and DenseNet169 models. MobileNetV2and DenseNet169 performed well in the Single classifier model, with anaccuracy of 94%, while the ensemble model (MobileNetV2+DenseNet169)achieved an accuracy of 96.9%. Using the data synchronous parallel modelin Distributed Tensorflow, the training process accelerated performance by98.6% and outperformed other conventional approaches.展开更多
We analyze the suitability of existing pre-trained transformer-based language models(PLMs)for abstractive text summarization on German technical healthcare texts.The study focuses on the multilingual capabilities of t...We analyze the suitability of existing pre-trained transformer-based language models(PLMs)for abstractive text summarization on German technical healthcare texts.The study focuses on the multilingual capabilities of these models and their ability to perform the task of abstractive text summarization in the healthcare field.The research hypothesis was that large language models could perform high-quality abstractive text summarization on German technical healthcare texts,even if the model is not specifically trained in that language.Through experiments,the research questions explore the performance of transformer language models in dealing with complex syntax constructs,the difference in performance between models trained in English and German,and the impact of translating the source text to English before conducting the summarization.We conducted an evaluation of four PLMs(GPT-3,a translation-based approach also utilizing GPT-3,a German language Model,and a domain-specific bio-medical model approach).The evaluation considered the informativeness using 3 types of metrics based on Recall-Oriented Understudy for Gisting Evaluation(ROUGE)and the quality of results which is manually evaluated considering 5 aspects.The results show that text summarization models could be used in the German healthcare domain and that domain-independent language models achieved the best results.The study proves that text summarization models can simplify the search for pre-existing German knowledge in various domains.展开更多
Current experimental and computational methods have limitations in accurately and efficiently classifying ion channels within vast protein spaces.Here we have developed a deep learning algorithm,GPT2 Ion Channel Class...Current experimental and computational methods have limitations in accurately and efficiently classifying ion channels within vast protein spaces.Here we have developed a deep learning algorithm,GPT2 Ion Channel Classifier(GPT2-ICC),which effectively distinguishing ion channels from a test set containing approximately 239 times more non-ion-channel proteins.GPT2-ICC integrates representation learning with a large language model(LLM)-based classifier,enabling highly accurate identification of potential ion channels.Several potential ion channels were predicated from the unannotated human proteome,further demonstrating GPT2-ICC’s generalization ability.This study marks a significant advancement in artificial-intelligence-driven ion channel research,highlighting the adaptability and effectiveness of combining representation learning with LLMs to address the challenges of imbalanced protein sequence data.Moreover,it provides a valuable computational tool for uncovering previously uncharacterized ion channels.展开更多
The Coronavirus Disease 2019(COVID-19)is wreaking havoc around the world,bring out that the enormous pressure on national health and medical staff systems.One of the most effective and critical steps in the fight agai...The Coronavirus Disease 2019(COVID-19)is wreaking havoc around the world,bring out that the enormous pressure on national health and medical staff systems.One of the most effective and critical steps in the fight against COVID-19,is to examine the patient’s lungs based on the Chest X-ray and CT generated by radiation imaging.In this paper,five keras-related deep learning models:ResNet50,InceptionResNetV2,Xception,transfer learning and pre-trained VGGNet16 is applied to formulate an classification-detection approaches of COVID-19.Two benchmark methods SVM(Support Vector Machine),CNN(Conventional Neural Networks)are provided to compare with the classification-detection approaches based on the performance indicators,i.e.,precision,recall,F1 scores,confusion matrix,classification accuracy and three types of AUC(Area Under Curve).The highest classification accuracy derived by classification-detection based on 5857 Chest X-rays and 767 Chest CTs are respectively 84%and 75%,which shows that the keras-related deep learning approaches facilitate accurate and effective COVID-19-assisted detection.展开更多
Rural domestic sewage treatment is critical for environmental protection.This study defines the spatial pattern of villages from the perspective of rural sewage treatment and develops an integrated decision-making sys...Rural domestic sewage treatment is critical for environmental protection.This study defines the spatial pattern of villages from the perspective of rural sewage treatment and develops an integrated decision-making system to propose a sewage treatment mode and scheme suitable for local conditions.By considering the village spatial layout and terrain factors,a decision tree model of residential density and terrain type was constructed with accuracies of 76.47%and 96.00%,respectively.Combined with binary classification probability unit regression,an appropriate sewage treatment mode for the village was determined with 87.00%accuracy.The Analytic Hierarchy Process(AHP),combined with the Technique for Order Preference(TOPSIS)by Similarity to an Ideal Solution model,formed the basis for optimal treatment process selection under different emission standards.Verification was conducted in 542 villages across three counties of the Inner Mongolia Autonomous Region,focusing on the standard effluent effect(0.3773),low investment cost(0.3196),and high standard effluent effect(0.5115)to determine the best treatment process for the same emission standard under different needs.The annual environmental and carbon emission benefits of sewage treatment in these villages were estimated.This model matches village density,geographic feature,and social development level,and provides scientific support and a theoretical basis for rural sewage treatment decision-making.展开更多
Recently, the emergence of pre-trained models(PTMs) has brought natural language processing(NLP) to a new era. In this survey, we provide a comprehensive review of PTMs for NLP. We first briefly introduce language rep...Recently, the emergence of pre-trained models(PTMs) has brought natural language processing(NLP) to a new era. In this survey, we provide a comprehensive review of PTMs for NLP. We first briefly introduce language representation learning and its research progress. Then we systematically categorize existing PTMs based on a taxonomy from four different perspectives. Next,we describe how to adapt the knowledge of PTMs to downstream tasks. Finally, we outline some potential directions of PTMs for future research. This survey is purposed to be a hands-on guide for understanding, using, and developing PTMs for various NLP tasks.展开更多
In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation ...In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation is provided”and that“the validation step is largely overlooked”.This assertion may have been true several years ago,for example,when Ochoa and Urbina-Cardona(2017)made a similar observation.However,there has been much work on ES model validation over the last decade.展开更多
Intelligent sorting is an important prerequisite for the full quantitative consumption and harmless disposal of kitchen waste.The existing object detection method based on an ImageNet pre-trained model is an effective...Intelligent sorting is an important prerequisite for the full quantitative consumption and harmless disposal of kitchen waste.The existing object detection method based on an ImageNet pre-trained model is an effective way of sorting.Owing to significant domain gaps between natural images and kitchen waste images,it is difficult to reflect the characteristics of diverse scales and dense distribution in kitchen waste based on an ImageNet pre-trained model,leading to poor generalisation.In this article,the authors propose the first pre-trained model for kitchen waste sorting called KitWaSor,which combines both contrastive learning(CL)and masked image modelling(MIM)through self-supervised learning(SSL).First,to address the issue of diverse scales,the authors propose a mixed masking strategy by introducing an incomplete masking branch based on the original random masking branch.It prevents the complete loss of small-scale objects while avoiding excessive leakage of large-scale object pixels.Second,to address the issue of dense distribution,the authors introduce semantic consistency constraints on the basis of the mixed masking strategy.That is,object semantic reasoning is performed through semantic consistency constraints to compensate for the lack of contextual information.To train KitWaSor,the authors construct the first million-level kitchen waste dataset across seasonal and regional distributions,named KWD-Million.Extensive experiments show that KitWaSor achieves state-of-the-art(SOTA)performance on the two most relevant downstream tasks for kitchen waste sorting(i.e.image classification and object detection),demonstrating the effectiveness of the proposed KitWaSor.展开更多
Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for mo...Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for model training and the overshadowing of crucial features within sequence concatenation.The current work proposes a less data-consuming model incorporating a pre-trained gene sequence model and a mutual information inference operator.Our methodology utilizes gene alignment and deduplication algorithms to preprocess gene sequences,enhancing the model’s capacity to discern and focus on distinctions among input gene pairs.The model,i.e.,DNA Pretrained Cross-Immunity Protection Inference model(DPCIPI),outperforms state-of-theart(SOTA)models in predicting hemagglutination inhibition titer from influenza viral gene sequences only.Improvement in binary cross-immunity prediction is 1.58%in F1,2.34%in precision,1.57%in recall,and 1.57%in Accuracy.For multilevel cross-immunity improvements,the improvement is 2.12%in F1,3.50%in precision,2.19%in recall,and 2.19%in Accuracy.Our study showcases the potential of pre-trained gene models to improve predictions of antigenic variation and cross-immunity.With expanding gene data and advancements in pre-trained models,this approach promises significant impacts on vaccine development and public health.展开更多
Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interact...Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interactions to predict future items of interest.However,many current methods rely on unique user and item IDs,limiting their ability to represent users and items effectively,especially in zero-shot learning scenarios where training data is scarce.With the rapid development of Large Language Models(LLMs),researchers are exploring their potential to enhance recommendation systems.However,there is a semantic gap between the linguistic semantics of LLMs and the collaborative semantics of recommendation systems,where items are typically indexed by IDs.Moreover,most research focuses on item representations,neglecting personalized user modeling.To address these issues,we propose a sequential recommendation framework using LLMs,called CIT-Rec,a model that integrates Collaborative semantics for user representation and Image and Text information for item representation to enhance Recommendations.Specifically,by aligning intuitive image information with text containing semantic features,we can more accurately represent items,improving item representation quality.We focus not only on item representations but also on user representations.To more precisely capture users’personalized preferences,we use traditional sequential recommendation models to train on users’historical interaction data,effectively capturing behavioral patterns.Finally,by combining LLMs and traditional sequential recommendation models,we allow the LLM to understand linguistic semantics while capturing collaborative semantics.Extensive evaluations on real-world datasets show that our model outperforms baseline methods,effectively combining user interaction history with item visual and textual modalities to provide personalized recommendations.展开更多
This study summarizes the theoretical basis,modeling strategies,pathological mechanisms,and therapeutic advances related to high-altitude qi-deficiency and blood-stasis pattern.Traditional concepts such as“qi drives ...This study summarizes the theoretical basis,modeling strategies,pathological mechanisms,and therapeutic advances related to high-altitude qi-deficiency and blood-stasis pattern.Traditional concepts such as“qi drives blood”and“deficiency leads to stasis”closely align with modern evidence demonstrating that hypoxia disrupts energy metabolism,impairs microcirculation,and amplifies inflammation and oxidative stress.Current animal models commonly use hypobaric hypoxia combined with fatigue loading,dietary restriction,ice-water stimulation,or adrenaline injection to mimic the combined effects of qi deficiency,blood stasis,and hypoxic injury.These composite approaches reproduce systemic abnormalities,including reduced arterial oxygen partial pressure,increased blood viscosity,impaired cardiac and pulmonary function,microcirculatory obstruction,and mitochondrial dysfunction.Enhanced inflammatory signaling,oxidative stress,and disturbances in metabolic and epigenetic networks further characterize the pattern.The findings indicate that its pathogenesis arises from multi-system,multi-target interactions rather than a single pathway.Representative herbal formulas,such as Buyang Huanwu decoction,Xuefu Zhuyu decoction,and prescriptions rich in Astragalus membranaceus(Fisch.)Bunge(A.membranaceus,Huang qi)or Salvia miltiorrhiza Bunge(S.miltiorrhiza,Dan Shen)have demonstrated the ability to improve energy metabolism,attenuate endothelial injury,enhance microcirculation,and suppress inflammation through network-level regulation.Future research should focus on standardizing exposure parameters,developing quantitative syndrome evaluation systems,and integrating multi-omics,systems biology and artificial intelligence to improve model reproducibility and mechanistic precision.These efforts may help establish objective criteria for high-altitude qi-deficiency and blood-stasis pattern and support the development of targeted therapeutic strategies.展开更多
With the urgent demand for generalized deep models,many pre-trained big models are proposed,such as bidirectional encoder representations(BERT),vision transformer(ViT),generative pre-trained transformers(GPT),etc.Insp...With the urgent demand for generalized deep models,many pre-trained big models are proposed,such as bidirectional encoder representations(BERT),vision transformer(ViT),generative pre-trained transformers(GPT),etc.Inspired by the success of these models in single domains(like computer vision and natural language processing),the multi-modal pre-trained big models have also drawn more and more attention in recent years.In this work,we give a comprehensive survey of these models and hope this paper could provide new insights and helps fresh researchers to track the most cutting-edge works.Specifically,we firstly introduce the background of multi-modal pre-training by reviewing the conventional deep learning,pre-training works in natural language process,computer vision,and speech.Then,we introduce the task definition,key challenges,and advantages of multi-modal pre-training models(MM-PTMs),and discuss the MM-PTMs with a focus on data,objectives,network architectures,and knowledge enhanced pre-training.After that,we introduce the downstream tasks used for the validation of large-scale MM-PTMs,including generative,classification,and regression tasks.We also give visualization and analysis of the model parameters and results on representative downstream tasks.Finally,we point out possible research directions for this topic that may benefit future works.In addition,we maintain a continuously updated paper list for large-scale pre-trained multi-modal big models:https://github.com/wangxiao5791509/MultiModal_BigModels_Survey.展开更多
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(...Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].展开更多
The collection and annotation of lar ge-scale bird datasets are resource-intensive and time-consuming processes that significantly limit the scalability and accuracy of biodiversity monitoring systems.While self-super...The collection and annotation of lar ge-scale bird datasets are resource-intensive and time-consuming processes that significantly limit the scalability and accuracy of biodiversity monitoring systems.While self-supervised learning(SSL)has emerged as a promising approach for leveraging unannotated data,current SSL methods face two critical challenges in bird species recognition:(1)long-tailed data distributions that result in poor performance on underrepresented species;and(2)domain shift issues caused by data augmentation strategies designed to mitigate class imbalance.Here we present SDNet,a novel SSL-based bird recognition framework that integrates diffusion models with large language models(LLMs)to overcome these limitations.SDNet employs LLMs to generate semantically rich textual descriptions for tail-class species by prompting the models with species taxonomy,morphological attributes,and habitat information,producing detailed natural language priors that capture fine-grained visual characteristics(e.g.,plumage patterns,body proportions,and distinctive markings).These textual descriptions are subsequently used by a conditional diffusion model to synthesize new bird image samples through cross-attention mechanisms that fuse textual embeddings with intermediate visual feature representations during the denoising process,ensuring generated images preserve species-specific morphological details while maintaining photorealistic quality.Additionally,we incorporate a Swin Transformer as the feature extraction backbone whose hierarchical window-based attention mechanism and shifted windowing scheme enable multi-scale local feature extraction that proves particularly effective at capturing finegrained discriminative patterns(such as beak shape and feather texture)while mitigating domain shift between synthetic and original images through consistent feature representations across both data sources.SDNet is validated on both a self-constructed dataset(Bird_BXS)an d a publicly available benchmark(Birds_25),demonstrating substantial improvements over conventional SSL approaches.Our results indicate that the synergistic integration of LLMs,diffusion models,and the Swin Transformer architecture contributes significantly to recognition accuracy,particularly for rare and morphologically similar species.These findings highlight the potential of SDNet for addressing fundamental limitations of existing SSL methods in avian recognition tasks and establishing a new paradigm for efficient self-supervised learning in large-scale ornithological vision applications.展开更多
Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work pr...Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work proposes Secured-FL,a blockchain-based defensive framework that combines smart contract-based authentication,clustering-driven outlier elimination,and dynamic threshold adjustment to defend against adversarial attacks.The framework was implemented on a private Ethereum network with a Proof-of-Authority consensus algorithm to ensure tamper-resistant and auditable model updates.Large-scale simulation on the Cyber Data dataset,under up to 50%malicious client settings,demonstrates Secured-FL achieves 6%-12%higher accuracy,9%-15%lower latency,and approximately 14%less computational expense compared to the PPSS benchmark framework.Additional tests,including confusion matrices,ROC and Precision-Recall curves,and ablation tests,confirm the interpretability and robustness of the defense.Tests for scalability also show consistent performance up to 500 clients,affirming appropriateness to reasonably large deployments.These results make Secured-FL a feasible,adversarially resilient FL paradigm with promising potential for application in smart cities,medicine,and other mission-critical IoT deployments.展开更多
With the increasing demand for understanding skin physiology and advancing regenerative medicine,in vitro three-dimensional(3D)functional skin tissue models have become vital tools in dermatological research.These mod...With the increasing demand for understanding skin physiology and advancing regenerative medicine,in vitro three-dimensional(3D)functional skin tissue models have become vital tools in dermatological research.These models effectively mimic the complex structure and functions of human skin.This review comprehensively discusses the latest advancements in construction techniques,material selection,and applications of 3D skin models.It highlights the advantages and challenges associated with cutting-edge technologies such as layer-by-layer cell coating,3D bioprinting,bio-spray technology,and photolithographic microfabrication in creating highly realistic skin models.Moreover,it examines the wide-ranging applications of 3D skin models,includingelucidation of skin disease mechanisms,investigation of skin barrier functions,studies on skin aging and repair,hair regeneration,efficacy screening of therapeutic agents,cosmetic safety assessment,and personalized medicine.Finally,this review anticipates future trends in developing 3D skin models with greater structural and functional complexity,enhanced multifunctionality,and improved clinical translation.展开更多
This study traces the development of the Shanghai Typhoon Model(SHTM)from a traditional physics-based regional model toward a data-driven,machine-learning typhoon forecasting system.After upgrading its initial and bou...This study traces the development of the Shanghai Typhoon Model(SHTM)from a traditional physics-based regional model toward a data-driven,machine-learning typhoon forecasting system.After upgrading its initial and boundary conditions,SHTM now leverages large-scale constraints from machine-learning weather prediction(MLWP)models,resulting in an ML–physics hybrid framework.During Typhoon Danas(2025),the hybrid SHTM achieves substantially lower track errors than both the advanced ECMWF Integrated Forecasting System(IFS)and leading MLWP models such as PanGu and FuXi.Furthermore,the hybrid SHTM consistently maintains mean track errors below 200 km up to a forecast lead time of 108 hours,representing a significant advancement in forecast accuracy.In addition,this study highlights the technical roadmap for transitioning from a physics-based typhoon model to a fully data-driven ML typhoon forecast system.It also emphasizes that advances in the physical modeling framework provide a critical foundation for further improving the performance of future data-driven ML typhoon models.展开更多
This study evaluated the accuracy,completeness,and comprehensibility of responses from mainstream large language models(LLMs)to hepatitis C virus(HCV)-related questions,aiming to assess their performance in addressing...This study evaluated the accuracy,completeness,and comprehensibility of responses from mainstream large language models(LLMs)to hepatitis C virus(HCV)-related questions,aiming to assess their performance in addressing patient queries about disease and lifestyle behaviors.The models selected were ChatGPT-4o,Gemini 2.0 Pro,Claude 3.5 Sonnet,and DeepSeek V3,with 12 questions chosen by two HCV experts from the domains of prevention,diagnosis,and treatment.展开更多
The rapid advancement of machine learning based tight-binding Hamiltonian(MLTB)methods has opened new avenues for efficient and accurate electronic structure simulations,particularly in large-scale systems and long-ti...The rapid advancement of machine learning based tight-binding Hamiltonian(MLTB)methods has opened new avenues for efficient and accurate electronic structure simulations,particularly in large-scale systems and long-time scenarios.This review begins with a concise overview of traditional tight-binding(TB)models,including both(semi-)empirical and first-principles approaches,establishing the foundation for understanding MLTB developments.We then present a systematic classification of existing MLTB methodologies,grouped into two major categories:direct prediction of TB Hamiltonian elements and inference of empirical parameters.A comparative analysis with other ML-based electronic structure models is also provided,highlighting the advancement of MLTB approaches.Finally,we explore the emerging MLTB application ecosystem,highlighting how the integration of MLTB models with a diverse suite of post-processing tools from linear-scaling solvers to quantum transport frameworks and molecular dynamics interfaces is essential for tackling complex scientific problems across different domains.The continued advancement of this integrated paradigm promises to accelerate materials discovery and open new frontiers in the predictive simulation of complex quantum phenomena.展开更多
文摘Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across various domains.However,the deployment of such models in resource-constrained environments presents a unique set of challenges that require innovative solutions.Resource-constrained environments encompass scenarios where computing resources,memory,and energy availability are restricted.To empower sentiment analysis in resource-constrained environments,we address the crucial need by leveraging lightweight pre-trained models.These models,derived from popular architectures such as DistilBERT,MobileBERT,ALBERT,TinyBERT,ELECTRA,and SqueezeBERT,offer a promising solution to the resource limitations imposed by these environments.By distilling the knowledge from larger models into smaller ones and employing various optimization techniques,these lightweight models aim to strike a balance between performance and resource efficiency.This paper endeavors to explore the performance of multiple lightweight pre-trained models in sentiment analysis tasks specific to such environments and provide insights into their viability for practical deployment.
文摘Pneumonia is an acute lung infection that has caused many fatalitiesglobally. Radiologists often employ chest X-rays to identify pneumoniasince they are presently the most effective imaging method for this purpose.Computer-aided diagnosis of pneumonia using deep learning techniques iswidely used due to its effectiveness and performance. In the proposed method,the Synthetic Minority Oversampling Technique (SMOTE) approach is usedto eliminate the class imbalance in the X-ray dataset. To compensate forthe paucity of accessible data, pre-trained transfer learning is used, and anensemble Convolutional Neural Network (CNN) model is developed. Theensemble model consists of all possible combinations of the MobileNetv2,Visual Geometry Group (VGG16), and DenseNet169 models. MobileNetV2and DenseNet169 performed well in the Single classifier model, with anaccuracy of 94%, while the ensemble model (MobileNetV2+DenseNet169)achieved an accuracy of 96.9%. Using the data synchronous parallel modelin Distributed Tensorflow, the training process accelerated performance by98.6% and outperformed other conventional approaches.
文摘We analyze the suitability of existing pre-trained transformer-based language models(PLMs)for abstractive text summarization on German technical healthcare texts.The study focuses on the multilingual capabilities of these models and their ability to perform the task of abstractive text summarization in the healthcare field.The research hypothesis was that large language models could perform high-quality abstractive text summarization on German technical healthcare texts,even if the model is not specifically trained in that language.Through experiments,the research questions explore the performance of transformer language models in dealing with complex syntax constructs,the difference in performance between models trained in English and German,and the impact of translating the source text to English before conducting the summarization.We conducted an evaluation of four PLMs(GPT-3,a translation-based approach also utilizing GPT-3,a German language Model,and a domain-specific bio-medical model approach).The evaluation considered the informativeness using 3 types of metrics based on Recall-Oriented Understudy for Gisting Evaluation(ROUGE)and the quality of results which is manually evaluated considering 5 aspects.The results show that text summarization models could be used in the German healthcare domain and that domain-independent language models achieved the best results.The study proves that text summarization models can simplify the search for pre-existing German knowledge in various domains.
基金funded by grants from the National Key Research and Development Program of China(Grant Nos.:2022YFE0205600 and 2022YFC3400504)the National Natural Science Foundation of China(Grant Nos.:82373792 and 82273857)the Fundamental Research Funds for the Central Universities,China,and the East China Normal University Medicine and Health Joint Fund,China(Grant No.:2022JKXYD07001).
文摘Current experimental and computational methods have limitations in accurately and efficiently classifying ion channels within vast protein spaces.Here we have developed a deep learning algorithm,GPT2 Ion Channel Classifier(GPT2-ICC),which effectively distinguishing ion channels from a test set containing approximately 239 times more non-ion-channel proteins.GPT2-ICC integrates representation learning with a large language model(LLM)-based classifier,enabling highly accurate identification of potential ion channels.Several potential ion channels were predicated from the unannotated human proteome,further demonstrating GPT2-ICC’s generalization ability.This study marks a significant advancement in artificial-intelligence-driven ion channel research,highlighting the adaptability and effectiveness of combining representation learning with LLMs to address the challenges of imbalanced protein sequence data.Moreover,it provides a valuable computational tool for uncovering previously uncharacterized ion channels.
基金This project is supported by National Natural Science Foundation of China(NSFC)(Nos.61902158,61806087)Graduate student innovation program for academic degrees in general university in Jiangsu Province(No.KYZZ16-0337).
文摘The Coronavirus Disease 2019(COVID-19)is wreaking havoc around the world,bring out that the enormous pressure on national health and medical staff systems.One of the most effective and critical steps in the fight against COVID-19,is to examine the patient’s lungs based on the Chest X-ray and CT generated by radiation imaging.In this paper,five keras-related deep learning models:ResNet50,InceptionResNetV2,Xception,transfer learning and pre-trained VGGNet16 is applied to formulate an classification-detection approaches of COVID-19.Two benchmark methods SVM(Support Vector Machine),CNN(Conventional Neural Networks)are provided to compare with the classification-detection approaches based on the performance indicators,i.e.,precision,recall,F1 scores,confusion matrix,classification accuracy and three types of AUC(Area Under Curve).The highest classification accuracy derived by classification-detection based on 5857 Chest X-rays and 767 Chest CTs are respectively 84%and 75%,which shows that the keras-related deep learning approaches facilitate accurate and effective COVID-19-assisted detection.
基金supported by the Central Government Guiding Local Science and Technology Development Fund Project(No.2024SZY0343)the Joint Research Program for Ecological Conservation and High Quality Development of the Yellow River Basin(No.2022-YRUC-01-050205)+2 种基金the Higher Education Scientific Research Project of Inner Mongolia Autonomous Region(No.NJZZ23078)the project of Inner Mongolia"Prairie Talents"Engineering Innovation Entrepreneurship Talent Team,the Major Projects of Erdos Science and Technology(No.2022EEDSKJZDZX015)the Innovation Team of the Inner Mongolia Academy of Science and Technology(No.CXTD2023-01-016).
文摘Rural domestic sewage treatment is critical for environmental protection.This study defines the spatial pattern of villages from the perspective of rural sewage treatment and develops an integrated decision-making system to propose a sewage treatment mode and scheme suitable for local conditions.By considering the village spatial layout and terrain factors,a decision tree model of residential density and terrain type was constructed with accuracies of 76.47%and 96.00%,respectively.Combined with binary classification probability unit regression,an appropriate sewage treatment mode for the village was determined with 87.00%accuracy.The Analytic Hierarchy Process(AHP),combined with the Technique for Order Preference(TOPSIS)by Similarity to an Ideal Solution model,formed the basis for optimal treatment process selection under different emission standards.Verification was conducted in 542 villages across three counties of the Inner Mongolia Autonomous Region,focusing on the standard effluent effect(0.3773),low investment cost(0.3196),and high standard effluent effect(0.5115)to determine the best treatment process for the same emission standard under different needs.The annual environmental and carbon emission benefits of sewage treatment in these villages were estimated.This model matches village density,geographic feature,and social development level,and provides scientific support and a theoretical basis for rural sewage treatment decision-making.
基金the National Natural Science Foundation of China(Grant Nos.61751201 and 61672162)the Shanghai Municipal Science and Technology Major Project(Grant No.2018SHZDZX01)and ZJLab。
文摘Recently, the emergence of pre-trained models(PTMs) has brought natural language processing(NLP) to a new era. In this survey, we provide a comprehensive review of PTMs for NLP. We first briefly introduce language representation learning and its research progress. Then we systematically categorize existing PTMs based on a taxonomy from four different perspectives. Next,we describe how to adapt the knowledge of PTMs to downstream tasks. Finally, we outline some potential directions of PTMs for future research. This survey is purposed to be a hands-on guide for understanding, using, and developing PTMs for various NLP tasks.
文摘In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation is provided”and that“the validation step is largely overlooked”.This assertion may have been true several years ago,for example,when Ochoa and Urbina-Cardona(2017)made a similar observation.However,there has been much work on ES model validation over the last decade.
基金National Key Research and Development Program of China,Grant/Award Number:2021YFC1910402。
文摘Intelligent sorting is an important prerequisite for the full quantitative consumption and harmless disposal of kitchen waste.The existing object detection method based on an ImageNet pre-trained model is an effective way of sorting.Owing to significant domain gaps between natural images and kitchen waste images,it is difficult to reflect the characteristics of diverse scales and dense distribution in kitchen waste based on an ImageNet pre-trained model,leading to poor generalisation.In this article,the authors propose the first pre-trained model for kitchen waste sorting called KitWaSor,which combines both contrastive learning(CL)and masked image modelling(MIM)through self-supervised learning(SSL).First,to address the issue of diverse scales,the authors propose a mixed masking strategy by introducing an incomplete masking branch based on the original random masking branch.It prevents the complete loss of small-scale objects while avoiding excessive leakage of large-scale object pixels.Second,to address the issue of dense distribution,the authors introduce semantic consistency constraints on the basis of the mixed masking strategy.That is,object semantic reasoning is performed through semantic consistency constraints to compensate for the lack of contextual information.To train KitWaSor,the authors construct the first million-level kitchen waste dataset across seasonal and regional distributions,named KWD-Million.Extensive experiments show that KitWaSor achieves state-of-the-art(SOTA)performance on the two most relevant downstream tasks for kitchen waste sorting(i.e.image classification and object detection),demonstrating the effectiveness of the proposed KitWaSor.
基金supported by the Bill & Melinda Gates Foundation and the Minderoo Foundation
文摘Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for model training and the overshadowing of crucial features within sequence concatenation.The current work proposes a less data-consuming model incorporating a pre-trained gene sequence model and a mutual information inference operator.Our methodology utilizes gene alignment and deduplication algorithms to preprocess gene sequences,enhancing the model’s capacity to discern and focus on distinctions among input gene pairs.The model,i.e.,DNA Pretrained Cross-Immunity Protection Inference model(DPCIPI),outperforms state-of-theart(SOTA)models in predicting hemagglutination inhibition titer from influenza viral gene sequences only.Improvement in binary cross-immunity prediction is 1.58%in F1,2.34%in precision,1.57%in recall,and 1.57%in Accuracy.For multilevel cross-immunity improvements,the improvement is 2.12%in F1,3.50%in precision,2.19%in recall,and 2.19%in Accuracy.Our study showcases the potential of pre-trained gene models to improve predictions of antigenic variation and cross-immunity.With expanding gene data and advancements in pre-trained models,this approach promises significant impacts on vaccine development and public health.
基金supported by the National Key R&D Program of China[2022YFF0902703]the State Administration for Market Regulation Science and Technology Plan Project(2024MK033).
文摘Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interactions to predict future items of interest.However,many current methods rely on unique user and item IDs,limiting their ability to represent users and items effectively,especially in zero-shot learning scenarios where training data is scarce.With the rapid development of Large Language Models(LLMs),researchers are exploring their potential to enhance recommendation systems.However,there is a semantic gap between the linguistic semantics of LLMs and the collaborative semantics of recommendation systems,where items are typically indexed by IDs.Moreover,most research focuses on item representations,neglecting personalized user modeling.To address these issues,we propose a sequential recommendation framework using LLMs,called CIT-Rec,a model that integrates Collaborative semantics for user representation and Image and Text information for item representation to enhance Recommendations.Specifically,by aligning intuitive image information with text containing semantic features,we can more accurately represent items,improving item representation quality.We focus not only on item representations but also on user representations.To more precisely capture users’personalized preferences,we use traditional sequential recommendation models to train on users’historical interaction data,effectively capturing behavioral patterns.Finally,by combining LLMs and traditional sequential recommendation models,we allow the LLM to understand linguistic semantics while capturing collaborative semantics.Extensive evaluations on real-world datasets show that our model outperforms baseline methods,effectively combining user interaction history with item visual and textual modalities to provide personalized recommendations.
基金supported by the National Key Research and Development Program,China(2022YFC3502103,2022YFC3502102)the National Natural Science Foundation of China,China(82204751).
文摘This study summarizes the theoretical basis,modeling strategies,pathological mechanisms,and therapeutic advances related to high-altitude qi-deficiency and blood-stasis pattern.Traditional concepts such as“qi drives blood”and“deficiency leads to stasis”closely align with modern evidence demonstrating that hypoxia disrupts energy metabolism,impairs microcirculation,and amplifies inflammation and oxidative stress.Current animal models commonly use hypobaric hypoxia combined with fatigue loading,dietary restriction,ice-water stimulation,or adrenaline injection to mimic the combined effects of qi deficiency,blood stasis,and hypoxic injury.These composite approaches reproduce systemic abnormalities,including reduced arterial oxygen partial pressure,increased blood viscosity,impaired cardiac and pulmonary function,microcirculatory obstruction,and mitochondrial dysfunction.Enhanced inflammatory signaling,oxidative stress,and disturbances in metabolic and epigenetic networks further characterize the pattern.The findings indicate that its pathogenesis arises from multi-system,multi-target interactions rather than a single pathway.Representative herbal formulas,such as Buyang Huanwu decoction,Xuefu Zhuyu decoction,and prescriptions rich in Astragalus membranaceus(Fisch.)Bunge(A.membranaceus,Huang qi)or Salvia miltiorrhiza Bunge(S.miltiorrhiza,Dan Shen)have demonstrated the ability to improve energy metabolism,attenuate endothelial injury,enhance microcirculation,and suppress inflammation through network-level regulation.Future research should focus on standardizing exposure parameters,developing quantitative syndrome evaluation systems,and integrating multi-omics,systems biology and artificial intelligence to improve model reproducibility and mechanistic precision.These efforts may help establish objective criteria for high-altitude qi-deficiency and blood-stasis pattern and support the development of targeted therapeutic strategies.
基金supported by National Natural Science Foundation of China(Nos.61872256 and 62102205)Key-Area Research and Development Program of Guangdong Province,China(No.2021B0101400002)+1 种基金Peng Cheng Laboratory Key Research Project,China(No.PCL 2021A07)Multi-source Cross-platform Video Analysis and Understanding for Intelligent Perception in Smart City,China(No.U20B2052).
文摘With the urgent demand for generalized deep models,many pre-trained big models are proposed,such as bidirectional encoder representations(BERT),vision transformer(ViT),generative pre-trained transformers(GPT),etc.Inspired by the success of these models in single domains(like computer vision and natural language processing),the multi-modal pre-trained big models have also drawn more and more attention in recent years.In this work,we give a comprehensive survey of these models and hope this paper could provide new insights and helps fresh researchers to track the most cutting-edge works.Specifically,we firstly introduce the background of multi-modal pre-training by reviewing the conventional deep learning,pre-training works in natural language process,computer vision,and speech.Then,we introduce the task definition,key challenges,and advantages of multi-modal pre-training models(MM-PTMs),and discuss the MM-PTMs with a focus on data,objectives,network architectures,and knowledge enhanced pre-training.After that,we introduce the downstream tasks used for the validation of large-scale MM-PTMs,including generative,classification,and regression tasks.We also give visualization and analysis of the model parameters and results on representative downstream tasks.Finally,we point out possible research directions for this topic that may benefit future works.In addition,we maintain a continuously updated paper list for large-scale pre-trained multi-modal big models:https://github.com/wangxiao5791509/MultiModal_BigModels_Survey.
文摘Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].
基金supported by the National Natural Science Foundation of China(32471964)。
文摘The collection and annotation of lar ge-scale bird datasets are resource-intensive and time-consuming processes that significantly limit the scalability and accuracy of biodiversity monitoring systems.While self-supervised learning(SSL)has emerged as a promising approach for leveraging unannotated data,current SSL methods face two critical challenges in bird species recognition:(1)long-tailed data distributions that result in poor performance on underrepresented species;and(2)domain shift issues caused by data augmentation strategies designed to mitigate class imbalance.Here we present SDNet,a novel SSL-based bird recognition framework that integrates diffusion models with large language models(LLMs)to overcome these limitations.SDNet employs LLMs to generate semantically rich textual descriptions for tail-class species by prompting the models with species taxonomy,morphological attributes,and habitat information,producing detailed natural language priors that capture fine-grained visual characteristics(e.g.,plumage patterns,body proportions,and distinctive markings).These textual descriptions are subsequently used by a conditional diffusion model to synthesize new bird image samples through cross-attention mechanisms that fuse textual embeddings with intermediate visual feature representations during the denoising process,ensuring generated images preserve species-specific morphological details while maintaining photorealistic quality.Additionally,we incorporate a Swin Transformer as the feature extraction backbone whose hierarchical window-based attention mechanism and shifted windowing scheme enable multi-scale local feature extraction that proves particularly effective at capturing finegrained discriminative patterns(such as beak shape and feather texture)while mitigating domain shift between synthetic and original images through consistent feature representations across both data sources.SDNet is validated on both a self-constructed dataset(Bird_BXS)an d a publicly available benchmark(Birds_25),demonstrating substantial improvements over conventional SSL approaches.Our results indicate that the synergistic integration of LLMs,diffusion models,and the Swin Transformer architecture contributes significantly to recognition accuracy,particularly for rare and morphologically similar species.These findings highlight the potential of SDNet for addressing fundamental limitations of existing SSL methods in avian recognition tasks and establishing a new paradigm for efficient self-supervised learning in large-scale ornithological vision applications.
文摘Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work proposes Secured-FL,a blockchain-based defensive framework that combines smart contract-based authentication,clustering-driven outlier elimination,and dynamic threshold adjustment to defend against adversarial attacks.The framework was implemented on a private Ethereum network with a Proof-of-Authority consensus algorithm to ensure tamper-resistant and auditable model updates.Large-scale simulation on the Cyber Data dataset,under up to 50%malicious client settings,demonstrates Secured-FL achieves 6%-12%higher accuracy,9%-15%lower latency,and approximately 14%less computational expense compared to the PPSS benchmark framework.Additional tests,including confusion matrices,ROC and Precision-Recall curves,and ablation tests,confirm the interpretability and robustness of the defense.Tests for scalability also show consistent performance up to 500 clients,affirming appropriateness to reasonably large deployments.These results make Secured-FL a feasible,adversarially resilient FL paradigm with promising potential for application in smart cities,medicine,and other mission-critical IoT deployments.
文摘With the increasing demand for understanding skin physiology and advancing regenerative medicine,in vitro three-dimensional(3D)functional skin tissue models have become vital tools in dermatological research.These models effectively mimic the complex structure and functions of human skin.This review comprehensively discusses the latest advancements in construction techniques,material selection,and applications of 3D skin models.It highlights the advantages and challenges associated with cutting-edge technologies such as layer-by-layer cell coating,3D bioprinting,bio-spray technology,and photolithographic microfabrication in creating highly realistic skin models.Moreover,it examines the wide-ranging applications of 3D skin models,includingelucidation of skin disease mechanisms,investigation of skin barrier functions,studies on skin aging and repair,hair regeneration,efficacy screening of therapeutic agents,cosmetic safety assessment,and personalized medicine.Finally,this review anticipates future trends in developing 3D skin models with greater structural and functional complexity,enhanced multifunctionality,and improved clinical translation.
基金supported by the Special Project-Original Exploration(Grant No.42450163)the National Youth Science Foundation of China Project(Grant No.4240050560)the Research and Development of Key Technologies for Artificial Intelligence Regional Typhoon Forecasting Model project.
文摘This study traces the development of the Shanghai Typhoon Model(SHTM)from a traditional physics-based regional model toward a data-driven,machine-learning typhoon forecasting system.After upgrading its initial and boundary conditions,SHTM now leverages large-scale constraints from machine-learning weather prediction(MLWP)models,resulting in an ML–physics hybrid framework.During Typhoon Danas(2025),the hybrid SHTM achieves substantially lower track errors than both the advanced ECMWF Integrated Forecasting System(IFS)and leading MLWP models such as PanGu and FuXi.Furthermore,the hybrid SHTM consistently maintains mean track errors below 200 km up to a forecast lead time of 108 hours,representing a significant advancement in forecast accuracy.In addition,this study highlights the technical roadmap for transitioning from a physics-based typhoon model to a fully data-driven ML typhoon forecast system.It also emphasizes that advances in the physical modeling framework provide a critical foundation for further improving the performance of future data-driven ML typhoon models.
基金funded by the National Key Research and Development Program of China(No.2021YFA1100500)the National Natural Science Foundation of China(No.82370662)the Key Research&Development Plan of Zhejiang Province(No.2024C03051).
文摘This study evaluated the accuracy,completeness,and comprehensibility of responses from mainstream large language models(LLMs)to hepatitis C virus(HCV)-related questions,aiming to assess their performance in addressing patient queries about disease and lifestyle behaviors.The models selected were ChatGPT-4o,Gemini 2.0 Pro,Claude 3.5 Sonnet,and DeepSeek V3,with 12 questions chosen by two HCV experts from the domains of prevention,diagnosis,and treatment.
基金supported by the Advanced Materials-National Science and Technology Major Project(Grant No.2025ZD0618401)the National Natural Science Foundation of China(Grant No.12504285)+1 种基金the Natural Science Foundation of Jiangsu Province(Grant No.BK20250472)NFSG grant from BITS-Pilani,Dubai campus。
文摘The rapid advancement of machine learning based tight-binding Hamiltonian(MLTB)methods has opened new avenues for efficient and accurate electronic structure simulations,particularly in large-scale systems and long-time scenarios.This review begins with a concise overview of traditional tight-binding(TB)models,including both(semi-)empirical and first-principles approaches,establishing the foundation for understanding MLTB developments.We then present a systematic classification of existing MLTB methodologies,grouped into two major categories:direct prediction of TB Hamiltonian elements and inference of empirical parameters.A comparative analysis with other ML-based electronic structure models is also provided,highlighting the advancement of MLTB approaches.Finally,we explore the emerging MLTB application ecosystem,highlighting how the integration of MLTB models with a diverse suite of post-processing tools from linear-scaling solvers to quantum transport frameworks and molecular dynamics interfaces is essential for tackling complex scientific problems across different domains.The continued advancement of this integrated paradigm promises to accelerate materials discovery and open new frontiers in the predictive simulation of complex quantum phenomena.
