Objective: to investigate and analyze the causes of acupuncture injuries among nurses in emergency department during pre-hospital emergency treatment, to put forward improvement measures to reduce the incidence of acu...Objective: to investigate and analyze the causes of acupuncture injuries among nurses in emergency department during pre-hospital emergency treatment, to put forward improvement measures to reduce the incidence of acupuncture injuries. Methods: 189 nurses in the emergency department of hospitals in Guangxi were investigated by questionnaire, and the related factors of acupuncture injury in pre-hospital emergency treatment were analyzed. Results: 21 subjects (11.11%) experienced acupuncture injuries. With the highest incidence (57.14%) occurring while the ambulance was driving. The percentage of sharp injuries contaminated by blood and body fluids of patients was 52.38%. 88.89% of the nurses considered the bumpy and unstable journey were the main reason for the occurrence of acupuncture injury. Conclusion: acupuncture injury is a common phenomenon among nurses in emergency department during pre-hospital emergency treatment. The self-prevention consciousness needs to be strengthened, and the protective measures and system need to be further improved.展开更多
To further improve the ability of pre-hospital and in-hospital collaborative treatment, strengthen emergency multidisciplinary cooperation and construct a scientific, rational and efficient emergency system, under the...To further improve the ability of pre-hospital and in-hospital collaborative treatment, strengthen emergency multidisciplinary cooperation and construct a scientific, rational and efficient emergency system, under the support of former chairman Yu Xue-zhong, Dr. Li Chun-sheng and numerous colleagues in the industry, the Emergency Medicine Society of the Chinese Medical Association appeal to us to draft Construction of Emergency and Pre-hospital Platform. Based on this background, the platform of emergency and pre-hospital first aid helps to build a 'one horizontal and one Longitudinal' treatment model, using the horizontal and longitudinal patterns to integrate emergency medical resources to satisfy the automatic information integration and intelligent analysis sharing, realizing the emergency management visualization and medical information digitization, simplifying the medical process and establishing a perfect standard for the emergent diseases, thereby ultimately achieving efficient diagnosis and scientific treatment.展开更多
目的 分析HIV/AIDS患者衰弱的研究热点,为该领域的研究提供临床参考和理论基础。方法 检索Web of Science(WOS)核心合集数据库2015年1月至2025年1月发表的HIV/AIDS患者衰弱相关的文献,采用CiteSpace软件对文献进行可视化分析。结果 共纳...目的 分析HIV/AIDS患者衰弱的研究热点,为该领域的研究提供临床参考和理论基础。方法 检索Web of Science(WOS)核心合集数据库2015年1月至2025年1月发表的HIV/AIDS患者衰弱相关的文献,采用CiteSpace软件对文献进行可视化分析。结果 共纳入251篇文献,在国家层面,发文量居首位的为美国(135篇),中国的发文量相对较少(10篇)。中介中心性最高的为南非(0.82)。在机构层面,发文量最高的为约翰斯·霍普金斯大学(51篇),中介中心性(0.10)仅次于伦敦大学(0.12)。关键词共现分析频次最高的前三个为older adults(老年人)、infection(感染)、phenotype(表型);关键词聚类共有13个标签;关键词突现结果显示近几年研究的关键词为depression(抑郁)、challenges(挑战)、index(指数)、people with HIV(HIV感染者)、people(人群)、predictor(预测因子)。结论 老年人是HIV/AIDS衰弱研究领域的核心人群,该领域的研究热点围绕优化老年HIV/AIDS患者的共病管理、提升cART效果、开发HIV/AIDS患者衰弱针对性评估工具展开。未来研究需加强HIV/AIDS患者社会心理因素的关注力度,贯彻落实以患者为中心的护理,提高预测因子识别HIV/AIDS患者衰弱的准确性,开展多学科合作。展开更多
Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentia...Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentiation 4(CD4)^(+)T lymphocyte(CD4 cell)counts—a condition known as immunological non-response(INRs).INRs are associated with elevated health risks,including increased susceptibility to AIDS-related and non-AIDS-related complications.The pathogenesis of INRs remains incompletely understood,and no established therapeutic interventions exist,posing a major challenge in contemporary HIV/AIDS management.Emerging evidence indicates that INRs exhibit significant alterations in gut microbiota composition.Dysbiosis of the gut microbiota may contribute to persistent immune activation,cytokine imbalance,and cellular pyroptosis,all of which could impair immune reconstitution in people living with HIV/AIDS.Traditional Chinese medicine(TCM)has demonstrated potential immunomodulatory effects and is increasingly utilized in the management of INRs.Targeting the gut microbiota and elucidating the mechanisms by which TCM modulates this microbial ecosystem may offer new avenues for preventing and treating INRs.This review explores the interplay between gut microbiota and TCM,examines the association between gut dysbiosis and INRs,discusses the mechanistic pathways through which microbiota imbalance contributes to INRs development,and highlights how TCM interventions regulate gut microbiota to promote immune recovery.By focusing on the gut microbiota as a therapeutic interface,this article provides novel insights into TCM-based strategies for improving outcomes in INRs and supports the development of innovative treatment approaches.展开更多
Background: Novel coronavirus pneumonia (NCP) and osteoporotic vertebral compression fractures (OVCF) are the high incidences of diseases in the elderly. During the epidemic period, if not treated in time, the complic...Background: Novel coronavirus pneumonia (NCP) and osteoporotic vertebral compression fractures (OVCF) are the high incidences of diseases in the elderly. During the epidemic period, if not treated in time, the complications are high and the mortality is high. If we do not pay attention to infection prevention and control in pre-hospital emergency care, it will lead to the first time infection of medical staff and in-hospital cross infection in emergency outpatient receiving area. The correct consideration of both and the establishment of perfect pre-hospital emergency treatment and infection prevention and control synchronous strategy is an important premise to ensure the stable, orderly and safe medical treatment. Objective: To explore the effect of synchronous implementation of pre-hospital emergency care, nursing and infection pre-vention and control for senile OVCF during the epidemic. In order to improve the efficiency of pre-hospital emergency care and prevent the spread of infection. Method: A total of 92 elderly patients with OVCF who received pre-hospital treatment in 18 hospitals in Zhangjiakou City during the epidemic prevention and control period from January 2020 to November 2022 and met the inclusion criteria were selected as research objects, including 24 males and 68 females, aged 65 - 82 (74.2 ± 2.2) years. All patients were associated with concomitant injuries and underlying diseases. All patients in this group underwent predictive pre-hospital rescue and infection prevention and control procedures. Results: All the 92 elderly patients with OVCF received timely pre-hospital treatment during the epidemic period, and no aggravation occurred of the 92 patients, 35 were in the high risk area, 10 were in the medium risk area, and 47 were in the low risk area. Exclude OVCF for NCP Patients were treated according to the conventional diagnosis and treatment principles. Suspected and confirmed cases are transferred to designated surgical hospitals for treatment. All patients were followed up 3 months, 6 months and 12 months after treatment. There was no death rate, high satisfaction of pre-hospital first aid, high diagnostic accuracy, and good curative effect. None of the rescue personnel had any infection rate, and no hospital infection transmission and nosocomial cross infection occurred. Conclusion: It is the first step to safely treat patients and prevent cross infection to establish a perfect synchronous strategy of pre-hospital first aid and infection prevention and control.展开更多
Objective: To investigate the occurrence of PTSD in pre-hospital emergency nurses and its related factors, and to compare the differences of neurotransmitter and immune-related factors between pre-hospital emergency n...Objective: To investigate the occurrence of PTSD in pre-hospital emergency nurses and its related factors, and to compare the differences of neurotransmitter and immune-related factors between pre-hospital emergency nurses who experienced traumatic events and those who did not develop PTSD and healthy people. How: Post-traumatic Stress Disorder Self-Rating Scale (PCL-C) tests were performed on pre-hospital emergency nurses in PTSD group, non-PTSD group and healthy control group, and the plasma monoamine neurotransmitters and serum cytokines were determined by double-antibody sandwich ABC-ELISA assay using enzyme-linked adsorption kit provided by Shanghai Xitang Biotechnology Co., Ltd. Results: 1) There were statistically significant differences in PCL-C scores between PTSD group, non-PTSD group and healthy group (p α between PTSD group, non-PTSD group and healthy group (p Conclusion: Pre-hospital emergency nurses should have early psychological intervention and guidance to reduce the occurrence of PTSD in emergency and emergency nurses.展开更多
Objective: to explore the effect of seamless pre-hospital emergency and emergency rescue on patients with acute myocardial infarction. Methods: our hospital within the last two years the rescue of 50 cases of patients...Objective: to explore the effect of seamless pre-hospital emergency and emergency rescue on patients with acute myocardial infarction. Methods: our hospital within the last two years the rescue of 50 cases of patients with acute myocardial infarction (mi), with the method of randomly selected from 25 patients were divided into group A (normal group), the other 25 patients in group B (optimization) in two groups of patients from the onset of symptoms to emergency personnel arrived at the treatment time, the percent of pass in and out of the emergency time, and after treatment were compared. Results: the first-aid effect rate of group B was higher than that of group A, and the satisfaction of first-aid measures of group B was higher than that of group A, the difference was significant, P<0.05. Conclusion: this emergency treatment measure is beneficial to improve the treatment rate of patients with acute myocardial infarction, this rescue measure can save the time of rescue and treatment, in addition, it is a new breakthrough in emergency medical treatment, worthy of promotion.展开更多
With the improvement of people's living standard and the continuation of healthy life, people's demand for emergency care is increasing. Pre-hospital emergency care plays an important role in rescuing patients...With the improvement of people's living standard and the continuation of healthy life, people's demand for emergency care is increasing. Pre-hospital emergency care plays an important role in rescuing patients and is a decisive factor in saving patients' lives. Nowadays, pre-hospital first aid mainly includes on-site first aid, monitoring of relevant vital signs sent to the hospital, and targeted treatment measures for different patients. Generally speaking, in pre-hospital first aid, due to the lack of first aid time and equipment, the possibility of dangerous situations in the first aid process increases, thus increasing the risk of first aid.展开更多
Objective: to study and analyze the application value of fiberoptic bronchoscopy-guided nasotracheal intubation in pre-hospital first aid. Methods: 60 pre-hospital emergency critical cases admitted in our hospital fro...Objective: to study and analyze the application value of fiberoptic bronchoscopy-guided nasotracheal intubation in pre-hospital first aid. Methods: 60 pre-hospital emergency critical cases admitted in our hospital from February 2020 to December 2021 were randomly divided into the research group and the control group with 30 cases in each group. All of them were treated with conventional pre-hospital emergency treatment. The research group was treated with nasotracheal intubation under the guidance of fiberoptic bronchoscope, while the control group was treated with open-vision endotracheal intubation. The effects of tracheal intubation and blood gas indexes before and after emergency treatment were evaluated and compared between the two groups.展开更多
Objective: To explore the therapeutic value of modified Valsalva manipulation in pre-hospital emergency treatment of paroxysmal ventricular tachycardia (PSVT). From January 2018 to December 2020, the patients with par...Objective: To explore the therapeutic value of modified Valsalva manipulation in pre-hospital emergency treatment of paroxysmal ventricular tachycardia (PSVT). From January 2018 to December 2020, the patients with paroxysmal ventricular tachycardia in our county from January 2018 to December 2020 were collected and randomly divided into standard group and variant group, with 30 cases in each group. Success rate of cardioversion and incidence of side effects. The success rate of sinus rhythm ECG conversion in standard group was significantly lower than that in improved group. The hospitalization rate of the improved group was significantly lower than that of the standard group. The incidence of chest tightness, dizziness, headache, hypotension and other adverse events in the deformation group is higher than that in the standard group, but the emergency treatment of tachycardia in the two groups before hospital can increase the success rate of heart conversion, reduce hospitalization, and will not significantly increase the incidence of side effects, which can be popularized and applied in pre-hospital emergency treatment.展开更多
目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细...目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细胞亚群CD11b、CD86、CD206的表达及巨噬细胞自噬探针CD11b+DALGreen、CD86+DALGreen、CD206+DALGreen的表达。ELISA法检测治疗前后血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-10、转化生长因子(TGF)-β1等炎性因子的表达。采用荧光定量PCR法检测治疗前后患者外周血中组蛋白去乙酰化酶(HDAC)2 m RNA、Unc-51样激酶1(ULK1)m RNA的表达。结果 治疗后,患者CD11b、CD206、CD11b+DALGreen、CD206+DALGreen、ULK1 m RNA表达明显升高(P<0.05);CD86、TNF-α、IL-1β、HDAC2 m RNA的表达明显下降(P<0.05);CD4^(+)T淋巴细胞计数、IL-10、TGF-β1表达呈上升趋势(P>0.05)。结论 参芩龙清肺培元颗粒可能通过调节HDAC2/ULK1信号轴,促进巨噬细胞自噬,调节M1/M2的平衡,抑制炎症反应,从而发挥治疗HIV/AIDS患者合并肺部感染的作用。展开更多
文摘Objective: to investigate and analyze the causes of acupuncture injuries among nurses in emergency department during pre-hospital emergency treatment, to put forward improvement measures to reduce the incidence of acupuncture injuries. Methods: 189 nurses in the emergency department of hospitals in Guangxi were investigated by questionnaire, and the related factors of acupuncture injury in pre-hospital emergency treatment were analyzed. Results: 21 subjects (11.11%) experienced acupuncture injuries. With the highest incidence (57.14%) occurring while the ambulance was driving. The percentage of sharp injuries contaminated by blood and body fluids of patients was 52.38%. 88.89% of the nurses considered the bumpy and unstable journey were the main reason for the occurrence of acupuncture injury. Conclusion: acupuncture injury is a common phenomenon among nurses in emergency department during pre-hospital emergency treatment. The self-prevention consciousness needs to be strengthened, and the protective measures and system need to be further improved.
文摘To further improve the ability of pre-hospital and in-hospital collaborative treatment, strengthen emergency multidisciplinary cooperation and construct a scientific, rational and efficient emergency system, under the support of former chairman Yu Xue-zhong, Dr. Li Chun-sheng and numerous colleagues in the industry, the Emergency Medicine Society of the Chinese Medical Association appeal to us to draft Construction of Emergency and Pre-hospital Platform. Based on this background, the platform of emergency and pre-hospital first aid helps to build a 'one horizontal and one Longitudinal' treatment model, using the horizontal and longitudinal patterns to integrate emergency medical resources to satisfy the automatic information integration and intelligent analysis sharing, realizing the emergency management visualization and medical information digitization, simplifying the medical process and establishing a perfect standard for the emergent diseases, thereby ultimately achieving efficient diagnosis and scientific treatment.
文摘目的 分析HIV/AIDS患者衰弱的研究热点,为该领域的研究提供临床参考和理论基础。方法 检索Web of Science(WOS)核心合集数据库2015年1月至2025年1月发表的HIV/AIDS患者衰弱相关的文献,采用CiteSpace软件对文献进行可视化分析。结果 共纳入251篇文献,在国家层面,发文量居首位的为美国(135篇),中国的发文量相对较少(10篇)。中介中心性最高的为南非(0.82)。在机构层面,发文量最高的为约翰斯·霍普金斯大学(51篇),中介中心性(0.10)仅次于伦敦大学(0.12)。关键词共现分析频次最高的前三个为older adults(老年人)、infection(感染)、phenotype(表型);关键词聚类共有13个标签;关键词突现结果显示近几年研究的关键词为depression(抑郁)、challenges(挑战)、index(指数)、people with HIV(HIV感染者)、people(人群)、predictor(预测因子)。结论 老年人是HIV/AIDS衰弱研究领域的核心人群,该领域的研究热点围绕优化老年HIV/AIDS患者的共病管理、提升cART效果、开发HIV/AIDS患者衰弱针对性评估工具展开。未来研究需加强HIV/AIDS患者社会心理因素的关注力度,贯彻落实以患者为中心的护理,提高预测因子识别HIV/AIDS患者衰弱的准确性,开展多学科合作。
基金supported by the National Natural Science Foundation of China(No.82274474)。
文摘Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentiation 4(CD4)^(+)T lymphocyte(CD4 cell)counts—a condition known as immunological non-response(INRs).INRs are associated with elevated health risks,including increased susceptibility to AIDS-related and non-AIDS-related complications.The pathogenesis of INRs remains incompletely understood,and no established therapeutic interventions exist,posing a major challenge in contemporary HIV/AIDS management.Emerging evidence indicates that INRs exhibit significant alterations in gut microbiota composition.Dysbiosis of the gut microbiota may contribute to persistent immune activation,cytokine imbalance,and cellular pyroptosis,all of which could impair immune reconstitution in people living with HIV/AIDS.Traditional Chinese medicine(TCM)has demonstrated potential immunomodulatory effects and is increasingly utilized in the management of INRs.Targeting the gut microbiota and elucidating the mechanisms by which TCM modulates this microbial ecosystem may offer new avenues for preventing and treating INRs.This review explores the interplay between gut microbiota and TCM,examines the association between gut dysbiosis and INRs,discusses the mechanistic pathways through which microbiota imbalance contributes to INRs development,and highlights how TCM interventions regulate gut microbiota to promote immune recovery.By focusing on the gut microbiota as a therapeutic interface,this article provides novel insights into TCM-based strategies for improving outcomes in INRs and supports the development of innovative treatment approaches.
文摘Background: Novel coronavirus pneumonia (NCP) and osteoporotic vertebral compression fractures (OVCF) are the high incidences of diseases in the elderly. During the epidemic period, if not treated in time, the complications are high and the mortality is high. If we do not pay attention to infection prevention and control in pre-hospital emergency care, it will lead to the first time infection of medical staff and in-hospital cross infection in emergency outpatient receiving area. The correct consideration of both and the establishment of perfect pre-hospital emergency treatment and infection prevention and control synchronous strategy is an important premise to ensure the stable, orderly and safe medical treatment. Objective: To explore the effect of synchronous implementation of pre-hospital emergency care, nursing and infection pre-vention and control for senile OVCF during the epidemic. In order to improve the efficiency of pre-hospital emergency care and prevent the spread of infection. Method: A total of 92 elderly patients with OVCF who received pre-hospital treatment in 18 hospitals in Zhangjiakou City during the epidemic prevention and control period from January 2020 to November 2022 and met the inclusion criteria were selected as research objects, including 24 males and 68 females, aged 65 - 82 (74.2 ± 2.2) years. All patients were associated with concomitant injuries and underlying diseases. All patients in this group underwent predictive pre-hospital rescue and infection prevention and control procedures. Results: All the 92 elderly patients with OVCF received timely pre-hospital treatment during the epidemic period, and no aggravation occurred of the 92 patients, 35 were in the high risk area, 10 were in the medium risk area, and 47 were in the low risk area. Exclude OVCF for NCP Patients were treated according to the conventional diagnosis and treatment principles. Suspected and confirmed cases are transferred to designated surgical hospitals for treatment. All patients were followed up 3 months, 6 months and 12 months after treatment. There was no death rate, high satisfaction of pre-hospital first aid, high diagnostic accuracy, and good curative effect. None of the rescue personnel had any infection rate, and no hospital infection transmission and nosocomial cross infection occurred. Conclusion: It is the first step to safely treat patients and prevent cross infection to establish a perfect synchronous strategy of pre-hospital first aid and infection prevention and control.
文摘Objective: To investigate the occurrence of PTSD in pre-hospital emergency nurses and its related factors, and to compare the differences of neurotransmitter and immune-related factors between pre-hospital emergency nurses who experienced traumatic events and those who did not develop PTSD and healthy people. How: Post-traumatic Stress Disorder Self-Rating Scale (PCL-C) tests were performed on pre-hospital emergency nurses in PTSD group, non-PTSD group and healthy control group, and the plasma monoamine neurotransmitters and serum cytokines were determined by double-antibody sandwich ABC-ELISA assay using enzyme-linked adsorption kit provided by Shanghai Xitang Biotechnology Co., Ltd. Results: 1) There were statistically significant differences in PCL-C scores between PTSD group, non-PTSD group and healthy group (p α between PTSD group, non-PTSD group and healthy group (p Conclusion: Pre-hospital emergency nurses should have early psychological intervention and guidance to reduce the occurrence of PTSD in emergency and emergency nurses.
文摘Objective: to explore the effect of seamless pre-hospital emergency and emergency rescue on patients with acute myocardial infarction. Methods: our hospital within the last two years the rescue of 50 cases of patients with acute myocardial infarction (mi), with the method of randomly selected from 25 patients were divided into group A (normal group), the other 25 patients in group B (optimization) in two groups of patients from the onset of symptoms to emergency personnel arrived at the treatment time, the percent of pass in and out of the emergency time, and after treatment were compared. Results: the first-aid effect rate of group B was higher than that of group A, and the satisfaction of first-aid measures of group B was higher than that of group A, the difference was significant, P<0.05. Conclusion: this emergency treatment measure is beneficial to improve the treatment rate of patients with acute myocardial infarction, this rescue measure can save the time of rescue and treatment, in addition, it is a new breakthrough in emergency medical treatment, worthy of promotion.
文摘With the improvement of people's living standard and the continuation of healthy life, people's demand for emergency care is increasing. Pre-hospital emergency care plays an important role in rescuing patients and is a decisive factor in saving patients' lives. Nowadays, pre-hospital first aid mainly includes on-site first aid, monitoring of relevant vital signs sent to the hospital, and targeted treatment measures for different patients. Generally speaking, in pre-hospital first aid, due to the lack of first aid time and equipment, the possibility of dangerous situations in the first aid process increases, thus increasing the risk of first aid.
文摘Objective: to study and analyze the application value of fiberoptic bronchoscopy-guided nasotracheal intubation in pre-hospital first aid. Methods: 60 pre-hospital emergency critical cases admitted in our hospital from February 2020 to December 2021 were randomly divided into the research group and the control group with 30 cases in each group. All of them were treated with conventional pre-hospital emergency treatment. The research group was treated with nasotracheal intubation under the guidance of fiberoptic bronchoscope, while the control group was treated with open-vision endotracheal intubation. The effects of tracheal intubation and blood gas indexes before and after emergency treatment were evaluated and compared between the two groups.
文摘Objective: To explore the therapeutic value of modified Valsalva manipulation in pre-hospital emergency treatment of paroxysmal ventricular tachycardia (PSVT). From January 2018 to December 2020, the patients with paroxysmal ventricular tachycardia in our county from January 2018 to December 2020 were collected and randomly divided into standard group and variant group, with 30 cases in each group. Success rate of cardioversion and incidence of side effects. The success rate of sinus rhythm ECG conversion in standard group was significantly lower than that in improved group. The hospitalization rate of the improved group was significantly lower than that of the standard group. The incidence of chest tightness, dizziness, headache, hypotension and other adverse events in the deformation group is higher than that in the standard group, but the emergency treatment of tachycardia in the two groups before hospital can increase the success rate of heart conversion, reduce hospitalization, and will not significantly increase the incidence of side effects, which can be popularized and applied in pre-hospital emergency treatment.
文摘目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细胞亚群CD11b、CD86、CD206的表达及巨噬细胞自噬探针CD11b+DALGreen、CD86+DALGreen、CD206+DALGreen的表达。ELISA法检测治疗前后血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-10、转化生长因子(TGF)-β1等炎性因子的表达。采用荧光定量PCR法检测治疗前后患者外周血中组蛋白去乙酰化酶(HDAC)2 m RNA、Unc-51样激酶1(ULK1)m RNA的表达。结果 治疗后,患者CD11b、CD206、CD11b+DALGreen、CD206+DALGreen、ULK1 m RNA表达明显升高(P<0.05);CD86、TNF-α、IL-1β、HDAC2 m RNA的表达明显下降(P<0.05);CD4^(+)T淋巴细胞计数、IL-10、TGF-β1表达呈上升趋势(P>0.05)。结论 参芩龙清肺培元颗粒可能通过调节HDAC2/ULK1信号轴,促进巨噬细胞自噬,调节M1/M2的平衡,抑制炎症反应,从而发挥治疗HIV/AIDS患者合并肺部感染的作用。
