The pandemic highlighted significant gaps in the public health infrastructure impacted by shortages of public health workers, an undertrained workforce, and years of disinvestment. These gaps required innovative probl...The pandemic highlighted significant gaps in the public health infrastructure impacted by shortages of public health workers, an undertrained workforce, and years of disinvestment. These gaps required innovative problem-solving by public health agencies (PHAs), including local health departments (LHDs), to respond to rapidly changing community conditions during and after the pandemic. Many schools and programs of public health (SPPH) worked with PHAs to mobilize public health (PH) students through practice-based teaching (PBT). Current research indicates PBT benefits all stakeholders—PHAs, students, faculty, SPPH, and ultimately the community served. However, more research is needed on the utility of PBT in addressing a community’s systemic public health issues, the extent to which the academic-community collaboration enhances a PHA’s capacity, and the impact of the pedagogy on preparing the workforce for an evolving PH landscape. This paper examines the process of a semester-long PBT course, guided by the PBT STEPS framework, which includes five steps from collaboration to implementation to evaluation of a PBT course. The collaborating PHA and its student group addressed community trauma and resilience issues during the semester. Additionally, it examines the longer-term impacts after the semester for the PHA, community, and the workforce by 1) conducting a formative evaluation to understand needs and gaps in the community;2) redesigning an intervention that merged the results of the formative evaluation with the intervention developed during the semester;and 3) securing funding and resources for intervention sustainability. Through the documentation of a post-course partnership between an LHD and faculty at a large school of public health, this case study illustrates the potential for PBT to lay the foundation for ongoing research that supports more impactful interventions for PHAs while bolstering the workforce abilities of students as future practitioners.展开更多
This study took the teaching practice of food-related majors in Chengdu University,a representative applied institution in China,as an example.Aligning with the course characteristics and educational objectives of Fun...This study took the teaching practice of food-related majors in Chengdu University,a representative applied institution in China,as an example.Aligning with the course characteristics and educational objectives of Functional Foods,it introduced the features of the BOPPPS teaching model and its implementation in course design.By incorporating research cases and presenting teaching examples,the steps and methods of BOPPPS-based teaching reform were explored while incorporating ideological and political elements into specialized instruction.This study provides insights and references for reforming other food-related courses and contributes to cultivating more food professionals with practical awareness and critical thinking.展开更多
As a product of the new century,artificial intelligence has been continuously developed and advanced.It has been applied to many fields,especially in the field of mechanical design and manufacturing.With the support o...As a product of the new century,artificial intelligence has been continuously developed and advanced.It has been applied to many fields,especially in the field of mechanical design and manufacturing.With the support of artificial intelligence,mechanical design and manufacturing can not only reduce input costs but also significantly reduce the demand for labor,playing a positive role in improving the design efficiency and quality of mechanical manufacturing[1].This paper studies how to apply artificial intelligence technology to the mechanical design and production process to achieve greater application and development.展开更多
Introduction Since the 21st century,the biomedical field has gained increasing attention.The biomedical field mainly encompasses biology,materials science,pharmacology,and drug delivery,etc.These areas hold significan...Introduction Since the 21st century,the biomedical field has gained increasing attention.The biomedical field mainly encompasses biology,materials science,pharmacology,and drug delivery,etc.These areas hold significant importance for human society in terms of health protection,disease diagnosis and treatment,via medical technology innovation and drug development.Consequently,scientists place great emphasis on research in this domain.It must be noted that the research process in biomedicine mainly includes topic selection,experimentation,analysis,and summary.Among these,topic selection is a critical step that affects the entire process.This topic selection not only clarifies the direction and objectives of the study but also provides a clear framework for subsequent research,thereby ensuring scientific rigor and effectiveness while laying a solid foundation for the result analysis.Thus,how to approach topic selection is a crucial issue that requires careful consideration.展开更多
The integration of academic research methodologies into design thinking processes presents a transformative approach to addressing complex challenges in group housing,fostering inclusive,sustainable,and user-centered ...The integration of academic research methodologies into design thinking processes presents a transformative approach to addressing complex challenges in group housing,fostering inclusive,sustainable,and user-centered solutions.This research explores how methodologies such as Participatory Action Research,post-occupancy evaluations,and Research through Design can be systematically embedded within design thinking to bridge the gap between academic rigor and empathy-driven,iterative design practices.By synthesizing these paradigms,the study proposes a framework for group housing design that prioritizes co-design processes,empathy-based data collection,and participatory evaluation,while emphasizing adaptability through sociocultural insights and user feedback.Case studies analysis demonstrate the effectiveness of flexible,community-driven design,while emerging technologies like IoT-enabled cohousing signal new opportunities for innovation.Challenges,including scalability,long-term validation,and reconciling user autonomy with professional expertise,are critically analyzed.Ultimately,this research advances a hybrid methodology to redefine the conceptualization,implementation,and assessment of group housing,offering actionable pathways to achieve affordable,inclusive,and context-sensitive housing solutions.展开更多
Attributing to their broad pharmacological effects encompassing anti-inflammation,antitoxin,and immunosuppression,glucocorticoids(GCs)are extensively utilized in the clinic for the treatment of diverse diseases such a...Attributing to their broad pharmacological effects encompassing anti-inflammation,antitoxin,and immunosuppression,glucocorticoids(GCs)are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus,nephritis,arthritis,ulcerative colitis,asthma,keratitis,macular edema,and leukemia.However,longterm use often causes undesirable side effects,including metabolic disorders-induced Cushing's syndrome(buffalo back,full moon face,hyperglycemia,etc.),osteoporosis,aggravated infection,psychosis,glaucoma,and cataract.These notorious side effects seriously compromise patients'quality of life,especially in patients with chronic diseases.Therefore,glucocorticoid-based advanced drug delivery systems for reducing adverse effects have received extensive attention.Among them,prodrugs have the advantages of low investment,low risk,and high success rate,making them a promising strategy.In this review,we propose the strategies for the design and summarize current research progress of glucocorticoid-based prodrugs in recent decades,including polymer-based prodrugs,dendrimer-based prodrugs,antibody-drug conjugates,peptide-drug conjugates,carbohydrate-based prodrugs,aliphatic acid-based prodrugs and so on.Besides,we also raise issues that need to be focused on during the development of glucocorticoid-based prodrugs.This review is expected to be helpful for the research and development of novel GCs and prodrugs.展开更多
This article examines the critical integration of reflexivity,cultural sensitivity,and emergent design in qualitative psychiatry research focused on lived experiences.While quantitative methods offer essential clinica...This article examines the critical integration of reflexivity,cultural sensitivity,and emergent design in qualitative psychiatry research focused on lived experiences.While quantitative methods offer essential clinical insights,qualitative approaches provide a deeper understanding of the emotional,psychological,and social dimensions of mental health.Reflexivity enables researchers to remain aware of how their personal biases and professional backgrounds shape data interpretation.Cultural sensitivity ensures that mental health conditions are understood within their broader cultural contexts,helping avoid misrepresentation and promoting authentic participant expression.Emergent design offers flexibility in adapting the research process to evolving themes,particularly in the dynamic and multifaceted realm of psychiatric conditions.Together,these principles promote ethically sound,participant-centered research that captures the full complexity of lived experiences.The article also highlighted the practical implications of these principles for enhancing both academic knowledge and clinical practice in psychiatry.展开更多
Practice-based research networks (PBRN) seek to improve healthcare through the use of research, quality improvement, and collaborative learning. When used by nontraditional models of care such as the nurse managed hea...Practice-based research networks (PBRN) seek to improve healthcare through the use of research, quality improvement, and collaborative learning. When used by nontraditional models of care such as the nurse managed healthcare center (NMHC), PBRNs can be incorporated into successful quality improvement (QI) programs. UT Health Services is a NMHC utilizing a PBRN as one component of a comprehensive QI program in an effort to deliver high quality healthcare.展开更多
Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmit...Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmits professional knowledge for students,enhances the students’professional ability,and further carries out in-depth research on the course to bring a better teaching effect for students.The article mainly focuses on the research of the principles of concrete structure design course,conducts an analysis of the teaching characteristics of the principles of concrete structure design course,and reasonably sets the teaching content from the optimization of the course teaching objectives;innovative course teaching methods can deepen the effect of knowledge understanding;reform of experimental practice teaching can lay down the effect of the internalization of knowledge,etc.The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research.展开更多
With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Techn...With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.展开更多
In recent years, with the development of technologies such as the Internet of Things(Io T), big data and cloud computing, digital twin technology has gradually been applied in marine research. The digital twin realize...In recent years, with the development of technologies such as the Internet of Things(Io T), big data and cloud computing, digital twin technology has gradually been applied in marine research. The digital twin realizes real-time monitoring, analysis and optimization of the state and behavior of a physical object or system by creating a virtual model. Research shows that digital twin technology has extensive application potential in ship design, marine resource development, marine equipment engineering design and optimization, marine ecological protection and early warning of disasters. Although digital twin technology has great potential in marine research, it also faces many challenges, including the complexity of data acquisition and processing, the accuracy and real-time performance of model construction, and the need for multidisciplinary cross-integration. An in-depth analysis of the technical bottlenecks and future development directions will provide an important reference for subsequent research and promote the further application and development of digital twin technology in marine research.展开更多
Stem cell-or tissue-derived three-dimensional organ-like formations,known as organoids,are emerging as effective tools in biomedicine.Since they may be useful in developing customized therapeutic solutions and efficie...Stem cell-or tissue-derived three-dimensional organ-like formations,known as organoids,are emerging as effective tools in biomedicine.Since they may be useful in developing customized therapeutic solutions and efficient drug screening protocols,organoids can deepen our understanding of novel disease mechanisms.In doing so,they can facilitate advancements in drug discovery platforms,pharmacological safety,and clinical trials.This review explores various biomedical applications of organoids,including drug development and disease modeling,and highlights specific tools and analytical techniques that can be employed to investigate organoids and their microenvironments.Finally,we review recent clinical trials and patents related to organoids that show great promise for future clinical translation.展开更多
In the year 1971,the world’s biggest structural biology collaboration name—The Research Collaboratory for Structural Bioinformatics(RCSB),was formed to gather all the structural biologists at a single platform and t...In the year 1971,the world’s biggest structural biology collaboration name—The Research Collaboratory for Structural Bioinformatics(RCSB),was formed to gather all the structural biologists at a single platform and then extended out to be the world’s most extensive structural data repository named RCSB-Protein Data Bank(PDB)(https://www.rcsb.org/)that has provided the service for more than 50 years and continues its legacy for the discoveries and repositories for structural data.The RCSB has evolved from being a collaboratory network to a full-fledged database and tool with a huge list of protein structures,nucleic acid-containing structures,ModelArchive,and AlphaFold structures,and the best is that it is expanding day by day with computational advancement with tools and visual experiences.In this review article,we have discussed how RCSB has been a successful collaboratory network,its expansion in each decade,and how it has helped the ground-breaking research.The PDB tools that are helping the researchers,yearly data deposition,validation,processing,and suggestions that can help the developer improve for upcoming years are also discussed.This review will help future researchers understand the complete history of RCSB and its developments in each decade and how various future collaborative networks can be developed in various scientific areas and can be successful by keeping RCSB as a case study.展开更多
To understand fundamental problems in hypersonic laminar-turbulent boundary layer transition for three-dimensional complex vehicles,a new standard model with typical lifting-body features has been proposed,named as hy...To understand fundamental problems in hypersonic laminar-turbulent boundary layer transition for three-dimensional complex vehicles,a new standard model with typical lifting-body features has been proposed,named as hypersonic transition research vehicle(HyTRV).The configuration of HyTRV is fully analytical,and details of the design process are discussed in this study.The transition characteristics for HyTRV are investigated using three combined methods,i.e.,theoretical analyses,numerical simulations,and wind tunnel experiments.Results show that the fully analytic parameterization design of HyTRV can satisfy the model simplification requirements from both numerical simulations and wind tunnel experiments.Meanwhile,the flow field of HyTRV reveals typical transition mechanisms in six relatively separated regions,including the streamwise vortex instability,crossflow instability,secondary instability,and attachment-line instability.Therefore,the proposed HyTRV model is valuable for fundamental researches in hypersonic boundary layer transition.展开更多
Safety systems, built on state-of-the-art technology, are essential for achieving acceptable levels of plant safety to minimize hazards to the reactor and the general public. The second shutdown system(SSS) as an engi...Safety systems, built on state-of-the-art technology, are essential for achieving acceptable levels of plant safety to minimize hazards to the reactor and the general public. The second shutdown system(SSS) as an engineered safety feature and a part of the reactor protection system(RPS) is a means for rapidly shutting down a nuclear reactor, keeping it in a subcritical state and serving as a backup to the first shutdown system(FSS). In this research, one SSS with two types of optimum chamber designs is proposed that take into account the main current characteristic features of the Tehran research reactor with improvements over earlier designs. They are based on a liquid neutron absorber injection that is preferably different, diverse, and independent from the FSS based on the rod drop mechanism. The major design characteristics of this SSS with two different chambers were investigated using MCNPX 2.6.0 code. The performed calculations showed that the designed SSS is a reliable shutdown system, assuring an appropriate shutdown margin and injection time, with no significant effects on the effective delayed neutron fraction while causing minimal variations to the core structure. Further, the reasonable financial cost and the prolongation of the operation cycle are additional advantages of this design.展开更多
Based on the analyses of the credit bank both at home and abroad, explore the effective way to construct the credit transfer model, find out the main problems in the process of transferring, design a much better model...Based on the analyses of the credit bank both at home and abroad, explore the effective way to construct the credit transfer model, find out the main problems in the process of transferring, design a much better model, formulate a new standard for credit transfer and carry out the research on the model design of the academic education's credit transfer in the open university.展开更多
Based on the research on the project course theory of "integration of theory and practice" in higher vocational education and the analysis of practical teaching in colleges and universities at home and abroa...Based on the research on the project course theory of "integration of theory and practice" in higher vocational education and the analysis of practical teaching in colleges and universities at home and abroad, combined with literature research, case analysis, system theory and other research methods, the project-based teaching goal, model, content and means of "integration of doing, learning and teaching" in higher vocational education is explored, and the project-based teaching model of "Landscape Planning and Design" is discussed combined with the application of information-based teaching methods. So as to provide references for carrying out the project-based teaching in similar courses in higher vocational colleges and really achieve docking the actual post requirements with the course to provide the basis for achieving the purpose of cultivating skilled talents in higher vocational education.展开更多
Matrix multiplication plays a pivotal role in the symmetric cipher algorithms, but it is one of the most complex and time consuming units, its performance directly affects the efficiency of cipher algorithms. Combined...Matrix multiplication plays a pivotal role in the symmetric cipher algorithms, but it is one of the most complex and time consuming units, its performance directly affects the efficiency of cipher algorithms. Combined with the characteristics of VLIW processor and matrix multiplication of symmetric cipher algorithms, this paper extracted the reconfigurable elements and analyzed the principle of matrix multiplication, then designed the reconfigurable architecture of matrix multiplication of VLIW processor further, at last we put forward single instructions for matrix multiplication between 4×1 and 4×4 matrix or two 4×4 matrix over GF(2~8), through the instructions extension, the instructions could support larger dimension operations. The experiment shows that the instructions we designed supports different dimensions matrix multiplication and improves the processing speed of multiplication greatly.展开更多
Alzheimer’s disease and related dementias have made a considerable impact on society, and can take a significant toll on familial caregivers. Recent successful caregiving interventions suggest a promising future, tho...Alzheimer’s disease and related dementias have made a considerable impact on society, and can take a significant toll on familial caregivers. Recent successful caregiving interventions suggest a promising future, though informed research design, a priori, is paramount in ensuring quality results that the Government and public may use to make informed policy and personal healthcare decisions. Research designs including basic science, randomized controlled trials (RCTs), qualitative, and quasi-experimental designs serve as the primary basis for discussion with literary examples and caveats.展开更多
文摘The pandemic highlighted significant gaps in the public health infrastructure impacted by shortages of public health workers, an undertrained workforce, and years of disinvestment. These gaps required innovative problem-solving by public health agencies (PHAs), including local health departments (LHDs), to respond to rapidly changing community conditions during and after the pandemic. Many schools and programs of public health (SPPH) worked with PHAs to mobilize public health (PH) students through practice-based teaching (PBT). Current research indicates PBT benefits all stakeholders—PHAs, students, faculty, SPPH, and ultimately the community served. However, more research is needed on the utility of PBT in addressing a community’s systemic public health issues, the extent to which the academic-community collaboration enhances a PHA’s capacity, and the impact of the pedagogy on preparing the workforce for an evolving PH landscape. This paper examines the process of a semester-long PBT course, guided by the PBT STEPS framework, which includes five steps from collaboration to implementation to evaluation of a PBT course. The collaborating PHA and its student group addressed community trauma and resilience issues during the semester. Additionally, it examines the longer-term impacts after the semester for the PHA, community, and the workforce by 1) conducting a formative evaluation to understand needs and gaps in the community;2) redesigning an intervention that merged the results of the formative evaluation with the intervention developed during the semester;and 3) securing funding and resources for intervention sustainability. Through the documentation of a post-course partnership between an LHD and faculty at a large school of public health, this case study illustrates the potential for PBT to lay the foundation for ongoing research that supports more impactful interventions for PHAs while bolstering the workforce abilities of students as future practitioners.
文摘This study took the teaching practice of food-related majors in Chengdu University,a representative applied institution in China,as an example.Aligning with the course characteristics and educational objectives of Functional Foods,it introduced the features of the BOPPPS teaching model and its implementation in course design.By incorporating research cases and presenting teaching examples,the steps and methods of BOPPPS-based teaching reform were explored while incorporating ideological and political elements into specialized instruction.This study provides insights and references for reforming other food-related courses and contributes to cultivating more food professionals with practical awareness and critical thinking.
文摘As a product of the new century,artificial intelligence has been continuously developed and advanced.It has been applied to many fields,especially in the field of mechanical design and manufacturing.With the support of artificial intelligence,mechanical design and manufacturing can not only reduce input costs but also significantly reduce the demand for labor,playing a positive role in improving the design efficiency and quality of mechanical manufacturing[1].This paper studies how to apply artificial intelligence technology to the mechanical design and production process to achieve greater application and development.
文摘Introduction Since the 21st century,the biomedical field has gained increasing attention.The biomedical field mainly encompasses biology,materials science,pharmacology,and drug delivery,etc.These areas hold significant importance for human society in terms of health protection,disease diagnosis and treatment,via medical technology innovation and drug development.Consequently,scientists place great emphasis on research in this domain.It must be noted that the research process in biomedicine mainly includes topic selection,experimentation,analysis,and summary.Among these,topic selection is a critical step that affects the entire process.This topic selection not only clarifies the direction and objectives of the study but also provides a clear framework for subsequent research,thereby ensuring scientific rigor and effectiveness while laying a solid foundation for the result analysis.Thus,how to approach topic selection is a crucial issue that requires careful consideration.
文摘The integration of academic research methodologies into design thinking processes presents a transformative approach to addressing complex challenges in group housing,fostering inclusive,sustainable,and user-centered solutions.This research explores how methodologies such as Participatory Action Research,post-occupancy evaluations,and Research through Design can be systematically embedded within design thinking to bridge the gap between academic rigor and empathy-driven,iterative design practices.By synthesizing these paradigms,the study proposes a framework for group housing design that prioritizes co-design processes,empathy-based data collection,and participatory evaluation,while emphasizing adaptability through sociocultural insights and user feedback.Case studies analysis demonstrate the effectiveness of flexible,community-driven design,while emerging technologies like IoT-enabled cohousing signal new opportunities for innovation.Challenges,including scalability,long-term validation,and reconciling user autonomy with professional expertise,are critically analyzed.Ultimately,this research advances a hybrid methodology to redefine the conceptualization,implementation,and assessment of group housing,offering actionable pathways to achieve affordable,inclusive,and context-sensitive housing solutions.
基金supported by the National Natural Science Foundation of China[82172086]National Key R&D Program of China[2020YFE0201700]+2 种基金Shenyang Science and Technology Talent Support Program[RC210447]Career Development Program for Young and Middle-aged Teachers of Shenyang Pharmaceutical University[ZQN2019004]“Dual Service”Program of University in Shenyang。
文摘Attributing to their broad pharmacological effects encompassing anti-inflammation,antitoxin,and immunosuppression,glucocorticoids(GCs)are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus,nephritis,arthritis,ulcerative colitis,asthma,keratitis,macular edema,and leukemia.However,longterm use often causes undesirable side effects,including metabolic disorders-induced Cushing's syndrome(buffalo back,full moon face,hyperglycemia,etc.),osteoporosis,aggravated infection,psychosis,glaucoma,and cataract.These notorious side effects seriously compromise patients'quality of life,especially in patients with chronic diseases.Therefore,glucocorticoid-based advanced drug delivery systems for reducing adverse effects have received extensive attention.Among them,prodrugs have the advantages of low investment,low risk,and high success rate,making them a promising strategy.In this review,we propose the strategies for the design and summarize current research progress of glucocorticoid-based prodrugs in recent decades,including polymer-based prodrugs,dendrimer-based prodrugs,antibody-drug conjugates,peptide-drug conjugates,carbohydrate-based prodrugs,aliphatic acid-based prodrugs and so on.Besides,we also raise issues that need to be focused on during the development of glucocorticoid-based prodrugs.This review is expected to be helpful for the research and development of novel GCs and prodrugs.
文摘This article examines the critical integration of reflexivity,cultural sensitivity,and emergent design in qualitative psychiatry research focused on lived experiences.While quantitative methods offer essential clinical insights,qualitative approaches provide a deeper understanding of the emotional,psychological,and social dimensions of mental health.Reflexivity enables researchers to remain aware of how their personal biases and professional backgrounds shape data interpretation.Cultural sensitivity ensures that mental health conditions are understood within their broader cultural contexts,helping avoid misrepresentation and promoting authentic participant expression.Emergent design offers flexibility in adapting the research process to evolving themes,particularly in the dynamic and multifaceted realm of psychiatric conditions.Together,these principles promote ethically sound,participant-centered research that captures the full complexity of lived experiences.The article also highlighted the practical implications of these principles for enhancing both academic knowledge and clinical practice in psychiatry.
文摘Practice-based research networks (PBRN) seek to improve healthcare through the use of research, quality improvement, and collaborative learning. When used by nontraditional models of care such as the nurse managed healthcare center (NMHC), PBRNs can be incorporated into successful quality improvement (QI) programs. UT Health Services is a NMHC utilizing a PBRN as one component of a comprehensive QI program in an effort to deliver high quality healthcare.
文摘Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmits professional knowledge for students,enhances the students’professional ability,and further carries out in-depth research on the course to bring a better teaching effect for students.The article mainly focuses on the research of the principles of concrete structure design course,conducts an analysis of the teaching characteristics of the principles of concrete structure design course,and reasonably sets the teaching content from the optimization of the course teaching objectives;innovative course teaching methods can deepen the effect of knowledge understanding;reform of experimental practice teaching can lay down the effect of the internalization of knowledge,etc.The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research.
文摘With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.
基金financially supported by the Key R&D Program of Shandong Province,China (Grant No. 2023ZLYS01)the National Natural Science Foundation of China (Grant No. 42106172)+8 种基金the Natural Science Foundation of Shandong Province (Grant Nos.ZR2024MD003, ZR2023QD023, ZR2023QD066 and ZR2023QD018)the Consulting and Researching Project of the Chinese Academy of Engineering(Grant Nos. 2024-DFZD-29, 2022-DFZD-35, 2022-XY-21, and 2021-XBZD-13-31)Qingdao Marine Science and Technology Innovation Project (Grant No. 23-1-3-hygg-6-hy)the Natural Science Foundation of Qingdao (Grant Nos. 23-2-1-58-zyyd-jch and 23-2-1-72-zyyd-jch)Project Plan of Pilot Project of Integration of Science,Education and Industry of Qilu University of Technology (Shandong Academy of Sciences)(Grant No. 2023PX035)the Visiting and Training Program for Teachers from Ordinary Undergraduate Universities in Shandong Provincethe Open Fund of Shandong Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation (Grant No. 202302)Major Innovation Project for the Science Education Industry Integration Pilot Project of Qilu University of Technology (Shandong Academy of Sciences)(Grant Nos. 2023HYZX01, and2023JBZ03)University-Industry Collaborative Education Program (Grant No. 202102245036)。
文摘In recent years, with the development of technologies such as the Internet of Things(Io T), big data and cloud computing, digital twin technology has gradually been applied in marine research. The digital twin realizes real-time monitoring, analysis and optimization of the state and behavior of a physical object or system by creating a virtual model. Research shows that digital twin technology has extensive application potential in ship design, marine resource development, marine equipment engineering design and optimization, marine ecological protection and early warning of disasters. Although digital twin technology has great potential in marine research, it also faces many challenges, including the complexity of data acquisition and processing, the accuracy and real-time performance of model construction, and the need for multidisciplinary cross-integration. An in-depth analysis of the technical bottlenecks and future development directions will provide an important reference for subsequent research and promote the further application and development of digital twin technology in marine research.
基金supported by the National Natural Science Foundation of China(No.82172567)Key R&D Plan of Jiangxi Province(No.2021BBG71006)the Key Project of Science and Technology Innovation of Health Commission of Jiangxi Province(Nos.2023ZD005 and 2024ZD008)。
文摘Stem cell-or tissue-derived three-dimensional organ-like formations,known as organoids,are emerging as effective tools in biomedicine.Since they may be useful in developing customized therapeutic solutions and efficient drug screening protocols,organoids can deepen our understanding of novel disease mechanisms.In doing so,they can facilitate advancements in drug discovery platforms,pharmacological safety,and clinical trials.This review explores various biomedical applications of organoids,including drug development and disease modeling,and highlights specific tools and analytical techniques that can be employed to investigate organoids and their microenvironments.Finally,we review recent clinical trials and patents related to organoids that show great promise for future clinical translation.
文摘In the year 1971,the world’s biggest structural biology collaboration name—The Research Collaboratory for Structural Bioinformatics(RCSB),was formed to gather all the structural biologists at a single platform and then extended out to be the world’s most extensive structural data repository named RCSB-Protein Data Bank(PDB)(https://www.rcsb.org/)that has provided the service for more than 50 years and continues its legacy for the discoveries and repositories for structural data.The RCSB has evolved from being a collaboratory network to a full-fledged database and tool with a huge list of protein structures,nucleic acid-containing structures,ModelArchive,and AlphaFold structures,and the best is that it is expanding day by day with computational advancement with tools and visual experiences.In this review article,we have discussed how RCSB has been a successful collaboratory network,its expansion in each decade,and how it has helped the ground-breaking research.The PDB tools that are helping the researchers,yearly data deposition,validation,processing,and suggestions that can help the developer improve for upcoming years are also discussed.This review will help future researchers understand the complete history of RCSB and its developments in each decade and how various future collaborative networks can be developed in various scientific areas and can be successful by keeping RCSB as a case study.
基金This work was supported by the National Natural Science Foundation of China(Grant 11702315,92052301)the National Key Research and Development Program of China(Grant 2016YFA0401200).
文摘To understand fundamental problems in hypersonic laminar-turbulent boundary layer transition for three-dimensional complex vehicles,a new standard model with typical lifting-body features has been proposed,named as hypersonic transition research vehicle(HyTRV).The configuration of HyTRV is fully analytical,and details of the design process are discussed in this study.The transition characteristics for HyTRV are investigated using three combined methods,i.e.,theoretical analyses,numerical simulations,and wind tunnel experiments.Results show that the fully analytic parameterization design of HyTRV can satisfy the model simplification requirements from both numerical simulations and wind tunnel experiments.Meanwhile,the flow field of HyTRV reveals typical transition mechanisms in six relatively separated regions,including the streamwise vortex instability,crossflow instability,secondary instability,and attachment-line instability.Therefore,the proposed HyTRV model is valuable for fundamental researches in hypersonic boundary layer transition.
文摘Safety systems, built on state-of-the-art technology, are essential for achieving acceptable levels of plant safety to minimize hazards to the reactor and the general public. The second shutdown system(SSS) as an engineered safety feature and a part of the reactor protection system(RPS) is a means for rapidly shutting down a nuclear reactor, keeping it in a subcritical state and serving as a backup to the first shutdown system(FSS). In this research, one SSS with two types of optimum chamber designs is proposed that take into account the main current characteristic features of the Tehran research reactor with improvements over earlier designs. They are based on a liquid neutron absorber injection that is preferably different, diverse, and independent from the FSS based on the rod drop mechanism. The major design characteristics of this SSS with two different chambers were investigated using MCNPX 2.6.0 code. The performed calculations showed that the designed SSS is a reliable shutdown system, assuring an appropriate shutdown margin and injection time, with no significant effects on the effective delayed neutron fraction while causing minimal variations to the core structure. Further, the reasonable financial cost and the prolongation of the operation cycle are additional advantages of this design.
文摘Based on the analyses of the credit bank both at home and abroad, explore the effective way to construct the credit transfer model, find out the main problems in the process of transferring, design a much better model, formulate a new standard for credit transfer and carry out the research on the model design of the academic education's credit transfer in the open university.
文摘Based on the research on the project course theory of "integration of theory and practice" in higher vocational education and the analysis of practical teaching in colleges and universities at home and abroad, combined with literature research, case analysis, system theory and other research methods, the project-based teaching goal, model, content and means of "integration of doing, learning and teaching" in higher vocational education is explored, and the project-based teaching model of "Landscape Planning and Design" is discussed combined with the application of information-based teaching methods. So as to provide references for carrying out the project-based teaching in similar courses in higher vocational colleges and really achieve docking the actual post requirements with the course to provide the basis for achieving the purpose of cultivating skilled talents in higher vocational education.
基金supported in part by open project foundation of State Key Laboratory of Cryptology National Natural Science Foundation of China (NSFC) under Grant No. 61272492, No. 61572521 and No. 61309008Natural Science Foundation for Young of Shaanxi Province under Grant No. 2013JQ8013
文摘Matrix multiplication plays a pivotal role in the symmetric cipher algorithms, but it is one of the most complex and time consuming units, its performance directly affects the efficiency of cipher algorithms. Combined with the characteristics of VLIW processor and matrix multiplication of symmetric cipher algorithms, this paper extracted the reconfigurable elements and analyzed the principle of matrix multiplication, then designed the reconfigurable architecture of matrix multiplication of VLIW processor further, at last we put forward single instructions for matrix multiplication between 4×1 and 4×4 matrix or two 4×4 matrix over GF(2~8), through the instructions extension, the instructions could support larger dimension operations. The experiment shows that the instructions we designed supports different dimensions matrix multiplication and improves the processing speed of multiplication greatly.
文摘Alzheimer’s disease and related dementias have made a considerable impact on society, and can take a significant toll on familial caregivers. Recent successful caregiving interventions suggest a promising future, though informed research design, a priori, is paramount in ensuring quality results that the Government and public may use to make informed policy and personal healthcare decisions. Research designs including basic science, randomized controlled trials (RCTs), qualitative, and quasi-experimental designs serve as the primary basis for discussion with literary examples and caveats.
