Kaposi’s sarcoma-associated herpesvirus(KSHV), also known as human herpesvirus-8(HHV-8), is etiologically linked to the development of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disea...Kaposi’s sarcoma-associated herpesvirus(KSHV), also known as human herpesvirus-8(HHV-8), is etiologically linked to the development of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. These malignancies often occur in immunosuppressed individuals, making KSHV infection-associated diseases an increasing global health concern with persistence of the AIDS epidemic. KSHV exhibits biphasic life cycles between latent and lytic infection and extensive transcriptional and posttranscriptional regulation of gene expression. As a member of the herpesvirus family, KSHV has evolved many strategies to evade the host immune response, which help the virus establish a successful lifelong infection. In this review, we summarize the current research status on the biology of latent and lytic viral infection, the regulation of viral life cycles and the related pathogenesis.展开更多
基金supported by the National Key R&D Program of China (2016YFA0502100)the Natural Science Foundation for Distinguished Young Scholars (81425017)+1 种基金the National Institutes of Health awarded (7R01AI116442) to K.Lthe Intramural Research Program of NCI/NIH (1ZIASC010357) to ZMZ
文摘Kaposi’s sarcoma-associated herpesvirus(KSHV), also known as human herpesvirus-8(HHV-8), is etiologically linked to the development of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. These malignancies often occur in immunosuppressed individuals, making KSHV infection-associated diseases an increasing global health concern with persistence of the AIDS epidemic. KSHV exhibits biphasic life cycles between latent and lytic infection and extensive transcriptional and posttranscriptional regulation of gene expression. As a member of the herpesvirus family, KSHV has evolved many strategies to evade the host immune response, which help the virus establish a successful lifelong infection. In this review, we summarize the current research status on the biology of latent and lytic viral infection, the regulation of viral life cycles and the related pathogenesis.
