Pulmonary rehabilitation has emerged as a recommended standard of care for patients with chronic lung disease. As in chronic obstructive pulmonary disease (COPD), persons with other forms of chronic respiratory diseas...Pulmonary rehabilitation has emerged as a recommended standard of care for patients with chronic lung disease. As in chronic obstructive pulmonary disease (COPD), persons with other forms of chronic respiratory disease commonly experience deconditioning and decreased quality of life. The aim of this prospective study is to determine the effect of a 4-week pulmonary rehabilitation program (PRP) on patients diagnosed with post-pulmonary tuberculosis bronchiectasis in the Philippines. The participants were above 18 years of age, diagnosed to have stable Post-Pulmonary tuberculosis bronchiectasis with chest computerized tomography (CT) scan or chest radiograph showing bronchiectatic changes, consented to attend the PRP sessions and be included in the study. The subjects underwent PRP for 4 weeks with a total of 8 sessions and determination of Forced expiratory volume at 1 second (FEV1), forced vital capacity (FVC), quality of life determination using the Saint George Respiratory Disease Questionnaire (SGRQ), and exercise endurance using the 6-minute walking test (6 MWT), before and after the PRP. A total of fourteen patients, six males and eight females, aged from 28 - 72 years old, completed the 4-week pulmonary rehabilitation program. There were four ex-smokers and ten non-smokers with concomitant asthma and COPD in some patients. There was significant improvement in the 6-minute walk test and quality of life after 4 weeks of rehabilitation program among the subjects with p value for 6 MWT at p = 0.0001 and p = 0.008 for SGRQ. Conclusion: Pulmonary rehabilitation program led to a significant improvement in exercise capacity and health related quality of life among patients with post-pulmonary tuberculosis bronchiectasis.展开更多
The burden of chronic airway diseases,including chronic obstructive pulmonary disease(COPD),continues to increase,especially in low-and middle-income countries.Post-tuberculosis lung disease(PTLD)is characterized by c...The burden of chronic airway diseases,including chronic obstructive pulmonary disease(COPD),continues to increase,especially in low-and middle-income countries.Post-tuberculosis lung disease(PTLD)is characterized by chronic lung changes after the"cure"of pulmonary tuberculosis(TB),which may be associated with the pathogenesis of COPD.However,data on its prevalence,clinical manifestations,computed tomography features,patterns of lung function impairment,and influencing factors are limited.The pathogenic mechanisms underlying PTLD remain to be elucidated.This review summarizes the recent advances in PTLD and TB-associated COPD.Research is urgently needed both for the prevention and management of PTLD.展开更多
This case report presents a 63-year-old male patient with a history of TB 20 years prior, who developed chronic cor pulmonale, right heart failure, and eventually died. The report emphasizes the serious long-term effe...This case report presents a 63-year-old male patient with a history of TB 20 years prior, who developed chronic cor pulmonale, right heart failure, and eventually died. The report emphasizes the serious long-term effects of post-TB sequelae, highlighting diagnostic challenges, clinical progression, and management strategies. The case report addresses a significant and often overlooked aspect of TB management: the long-term complications following TB treatment, known as post-TB sequelae.展开更多
Tuberculosis(TB)significantly increases the risk of developing chronic obstructive pulmonary disease(COPD),po-sitioning TB-associated COPD(TB-COPD)as a distinct category within the spectrum of respiratory diseases pre...Tuberculosis(TB)significantly increases the risk of developing chronic obstructive pulmonary disease(COPD),po-sitioning TB-associated COPD(TB-COPD)as a distinct category within the spectrum of respiratory diseases preva-lent,especially in low-and middle-income countries.This condition results from the body’s immune response to TB,leading to prolonged inflammation and consequent persistent lung damage.Diagnostic approaches,par-ticularly post-bronchodilator spirometry,are vital for identifying airflow obstruction and confirming TB-COPD.Furthermore,exploring potential biomarkers is crucial for a deeper insight into the pathogenesis of TB-COPD and the improvement of treatment strategies.Currently,this condition is primarily managed using inhaled bron-chodilators,with cautious use of inhaled corticosteroids advised owing to the increased risk of developing TB.This review delves into the epidemiology,clinical manifestations,pulmonary function,and imaging character-istics of TB-COPD,scrutinizing current and prospective biomarkers and therapeutic strategies.Furthermore,it underscores the necessity for focused research to bridge the knowledge and treatment gaps in this complex con-dition.展开更多
文摘Pulmonary rehabilitation has emerged as a recommended standard of care for patients with chronic lung disease. As in chronic obstructive pulmonary disease (COPD), persons with other forms of chronic respiratory disease commonly experience deconditioning and decreased quality of life. The aim of this prospective study is to determine the effect of a 4-week pulmonary rehabilitation program (PRP) on patients diagnosed with post-pulmonary tuberculosis bronchiectasis in the Philippines. The participants were above 18 years of age, diagnosed to have stable Post-Pulmonary tuberculosis bronchiectasis with chest computerized tomography (CT) scan or chest radiograph showing bronchiectatic changes, consented to attend the PRP sessions and be included in the study. The subjects underwent PRP for 4 weeks with a total of 8 sessions and determination of Forced expiratory volume at 1 second (FEV1), forced vital capacity (FVC), quality of life determination using the Saint George Respiratory Disease Questionnaire (SGRQ), and exercise endurance using the 6-minute walking test (6 MWT), before and after the PRP. A total of fourteen patients, six males and eight females, aged from 28 - 72 years old, completed the 4-week pulmonary rehabilitation program. There were four ex-smokers and ten non-smokers with concomitant asthma and COPD in some patients. There was significant improvement in the 6-minute walk test and quality of life after 4 weeks of rehabilitation program among the subjects with p value for 6 MWT at p = 0.0001 and p = 0.008 for SGRQ. Conclusion: Pulmonary rehabilitation program led to a significant improvement in exercise capacity and health related quality of life among patients with post-pulmonary tuberculosis bronchiectasis.
基金supported by grants from the National Natural Science Foundation(Nos.81400041 and 8217010845)the Capital’s Funds for Health Improvement and Research(No.2022-2G-40910)the Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2022014)
文摘The burden of chronic airway diseases,including chronic obstructive pulmonary disease(COPD),continues to increase,especially in low-and middle-income countries.Post-tuberculosis lung disease(PTLD)is characterized by chronic lung changes after the"cure"of pulmonary tuberculosis(TB),which may be associated with the pathogenesis of COPD.However,data on its prevalence,clinical manifestations,computed tomography features,patterns of lung function impairment,and influencing factors are limited.The pathogenic mechanisms underlying PTLD remain to be elucidated.This review summarizes the recent advances in PTLD and TB-associated COPD.Research is urgently needed both for the prevention and management of PTLD.
文摘This case report presents a 63-year-old male patient with a history of TB 20 years prior, who developed chronic cor pulmonale, right heart failure, and eventually died. The report emphasizes the serious long-term effects of post-TB sequelae, highlighting diagnostic challenges, clinical progression, and management strategies. The case report addresses a significant and often overlooked aspect of TB management: the long-term complications following TB treatment, known as post-TB sequelae.
基金supported by the National Natural Science Foundation of China(Nos.81400041,8217010845)Capital’s Funds for Health Improvement and Research(No.2022-2G-40910)+1 种基金Key Clinical Projects of Peking University Third Hospital(No.BYSYZD2022014)Peking University Medicine Fund of Fostering Young Scholars’Scientific&Technological Innovation(No.BMU2024YFJHPY014)supported by Fundamental Research Funds for the Central Universities.The funding bodies had no role in the design and writing of the manuscript。
文摘Tuberculosis(TB)significantly increases the risk of developing chronic obstructive pulmonary disease(COPD),po-sitioning TB-associated COPD(TB-COPD)as a distinct category within the spectrum of respiratory diseases preva-lent,especially in low-and middle-income countries.This condition results from the body’s immune response to TB,leading to prolonged inflammation and consequent persistent lung damage.Diagnostic approaches,par-ticularly post-bronchodilator spirometry,are vital for identifying airflow obstruction and confirming TB-COPD.Furthermore,exploring potential biomarkers is crucial for a deeper insight into the pathogenesis of TB-COPD and the improvement of treatment strategies.Currently,this condition is primarily managed using inhaled bron-chodilators,with cautious use of inhaled corticosteroids advised owing to the increased risk of developing TB.This review delves into the epidemiology,clinical manifestations,pulmonary function,and imaging character-istics of TB-COPD,scrutinizing current and prospective biomarkers and therapeutic strategies.Furthermore,it underscores the necessity for focused research to bridge the knowledge and treatment gaps in this complex con-dition.
