Background:Habitual physical activity is known to support cardiovascular health.However,when intensive exercise is performed for long durations,it can negatively affect the cardiovascular system.We evaluated the exerc...Background:Habitual physical activity is known to support cardiovascular health.However,when intensive exercise is performed for long durations,it can negatively affect the cardiovascular system.We evaluated the exercise-induced physiological responses of cardiac markers in male marathon runners based on basal plasma trimethylamine-N-oxide(TMAO)levels,a metabolite related to major adverse cardiovascular events.Methods:Blood samples from 28 marathon runners were collected two weeks before the marathon run(baseline),after finishing the race(post-marathon),and two weeks after the race(2 weeks post-marathon).Serum cardiac troponin I(c Tn I),endothelin-1(ET-1),galectin-3,pentraxin-3,human growth differentiation factor 15,and neopterin were determined by the enzyme immunoassay method.Plasma trimethylamine(TMA)and TMAO were measured by the ultra-high-performance liquid chromatography-mass spectrometry method.Results:Running a marathon increased levels of circulating biomarkers.A greater post-marathon elevation of cTn I and ET-1 was associated with baseline plasma TMAO levels(R=0.400,p=0.035 and R=0.476,p=0.012,respectively).Moreover,we observed an increase in post-marathon TMA levels.Conclusion:Greater post-marathon elevation of cTn I and ET-1 was associated with higher baseline plasma TMAO levels.Therefore,TMAO could potentially serve as a new marker in assessing the response of cardiovascular stress biomarkers to marathon running.展开更多
基金supported by the Polish Ministry of Science and Higher Education,grant no.2/566516/SPUB/SP/2023。
文摘Background:Habitual physical activity is known to support cardiovascular health.However,when intensive exercise is performed for long durations,it can negatively affect the cardiovascular system.We evaluated the exercise-induced physiological responses of cardiac markers in male marathon runners based on basal plasma trimethylamine-N-oxide(TMAO)levels,a metabolite related to major adverse cardiovascular events.Methods:Blood samples from 28 marathon runners were collected two weeks before the marathon run(baseline),after finishing the race(post-marathon),and two weeks after the race(2 weeks post-marathon).Serum cardiac troponin I(c Tn I),endothelin-1(ET-1),galectin-3,pentraxin-3,human growth differentiation factor 15,and neopterin were determined by the enzyme immunoassay method.Plasma trimethylamine(TMA)and TMAO were measured by the ultra-high-performance liquid chromatography-mass spectrometry method.Results:Running a marathon increased levels of circulating biomarkers.A greater post-marathon elevation of cTn I and ET-1 was associated with baseline plasma TMAO levels(R=0.400,p=0.035 and R=0.476,p=0.012,respectively).Moreover,we observed an increase in post-marathon TMA levels.Conclusion:Greater post-marathon elevation of cTn I and ET-1 was associated with higher baseline plasma TMAO levels.Therefore,TMAO could potentially serve as a new marker in assessing the response of cardiovascular stress biomarkers to marathon running.
