Exposure to stress negatively affects error processing,but the impact of stress on error awareness remains to be determined.In the present study,we examined the temporal dynamics of error awareness and post-error adju...Exposure to stress negatively affects error processing,but the impact of stress on error awareness remains to be determined.In the present study,we examined the temporal dynamics of error awareness and post-error adjustment following acute stress.Forty-nine healthy men were randomly assigned to the control(n=26)or stress group(n=23).After stress induction,participants completed the error awareness task,and their brain activity was assessed by electroencephalography.Compared to the control group,the stress group demonstrated lower error awareness accuracy and smaller Pe(error positivity)andΔPe amplitudes following aware error responses,which indicated impairment of error awareness following stress.Furthermore,the stress group had lower accuracy in post-aware error responses than in post-unaware error responses and the control group,which indicated poor post-error adjustment following stress.Our results showed a stress effect on sequential stages of error processing.Stress induces impaired error identification,which further generates maladaptive post-error performance.展开更多
Behavioral adjustment plays an important role in the treatment and relapse of drug addiction. Nonetheless,few studies have examined behavioral adjustment and its plasticity following error commission in methamphetamin...Behavioral adjustment plays an important role in the treatment and relapse of drug addiction. Nonetheless,few studies have examined behavioral adjustment and its plasticity following error commission in methamphetamine（METH） dependence, which is detrimental to human health. Thus, we investigated the behavioral adjustment performance following error commission in long-term METH addicts and how it varied with the application of repetitive transcranial magnetic stimulation（r TMS） of the left dorsolateral prefrontal cortex（DLPFC）. Twenty-nine male long-term METH addicts（for [ 3 years） were randomly assigned to high-frequency（10 Hz, n = 15） or sham（n = 14） r TMS of the left DLPFC during a two-choice oddball task. Twenty-six age-matched, healthy male adults participated in the two-choice oddball task pretest to establish normal performance for comparison. The results showed that 10 Hz r TMS over the left DLPFC significantly decreased the post-error slowing effect in response times of METH addicts. In addition, the 10 Hz r TMS intervention remarkably reduced the reaction times during post-error trials but not post-correct trials. While the 10 Hz r TMS group showed a more pronounced post-error slowing effect than the healthy participants during the pretest, the posterror slowing effect in the posttest of this sample was similar to that in the healthy participants. These results suggest that high-frequency r TMS over the left DLPFC is a useful protocol for the improvement of behavioral adjustment after error commission in long-term METH addicts.展开更多
基金supported by grants from the National Natural Science Foundation of China(32200878 and 32260206)the Annual 2022 Joint Project of Basic Research in Local Universities(part)in Yunnan province(202101BA070001-156)+1 种基金the Annual 2021 Educational Science Planning Project of Yunnan Province(BFSJY006)the Kunming University Talent Introduction Research Project(YJW2213).
文摘Exposure to stress negatively affects error processing,but the impact of stress on error awareness remains to be determined.In the present study,we examined the temporal dynamics of error awareness and post-error adjustment following acute stress.Forty-nine healthy men were randomly assigned to the control(n=26)or stress group(n=23).After stress induction,participants completed the error awareness task,and their brain activity was assessed by electroencephalography.Compared to the control group,the stress group demonstrated lower error awareness accuracy and smaller Pe(error positivity)andΔPe amplitudes following aware error responses,which indicated impairment of error awareness following stress.Furthermore,the stress group had lower accuracy in post-aware error responses than in post-unaware error responses and the control group,which indicated poor post-error adjustment following stress.Our results showed a stress effect on sequential stages of error processing.Stress induces impaired error identification,which further generates maladaptive post-error performance.
基金supported by the National Natural Science Foundation of China (31371042, 31400906 and 31600886)the Key Program of the Higher Education Institutions of Henan Province, China (17AJ90002)
文摘Behavioral adjustment plays an important role in the treatment and relapse of drug addiction. Nonetheless,few studies have examined behavioral adjustment and its plasticity following error commission in methamphetamine（METH） dependence, which is detrimental to human health. Thus, we investigated the behavioral adjustment performance following error commission in long-term METH addicts and how it varied with the application of repetitive transcranial magnetic stimulation（r TMS） of the left dorsolateral prefrontal cortex（DLPFC）. Twenty-nine male long-term METH addicts（for [ 3 years） were randomly assigned to high-frequency（10 Hz, n = 15） or sham（n = 14） r TMS of the left DLPFC during a two-choice oddball task. Twenty-six age-matched, healthy male adults participated in the two-choice oddball task pretest to establish normal performance for comparison. The results showed that 10 Hz r TMS over the left DLPFC significantly decreased the post-error slowing effect in response times of METH addicts. In addition, the 10 Hz r TMS intervention remarkably reduced the reaction times during post-error trials but not post-correct trials. While the 10 Hz r TMS group showed a more pronounced post-error slowing effect than the healthy participants during the pretest, the posterror slowing effect in the posttest of this sample was similar to that in the healthy participants. These results suggest that high-frequency r TMS over the left DLPFC is a useful protocol for the improvement of behavioral adjustment after error commission in long-term METH addicts.
