Background:Exercise induces molecular changes that involve multiple organs and tissues.Moreover,these changes are modulated by various exercise parameters—such as intensity,frequency,mode,and duration—as well as by ...Background:Exercise induces molecular changes that involve multiple organs and tissues.Moreover,these changes are modulated by various exercise parameters—such as intensity,frequency,mode,and duration—as well as by clinical features like gender,age,and body mass index(BMI),each eliciting distinct biological effects.To assist exercise researchers in understanding these changes from a comprehensive perspective that includes multiple organs,diverse exercise regimens,and a range of clinical features,we developed Exercise Regulated Genes Database(ExerGeneDB),a database of exercise-regulated differential genes.Methods:ExerGeneDB aggregated publicly available exercise-related sequencing datasets and subjected them to uniform quality control and preprocessing.The data,encompassing a variety of types,were organized into a specialized database of exercise-regulated genes.Notably,Exer-GeneDB conducted differential analyses on this collected data,leveraging curated clinical information and accounting for important factors such as gender,age,and BMI.Results:ExerGeneDB has assembled 1692 samples from rats and mice as well as 4492 human samples.It contains data from various tissues and organs,such as skeletal muscle,blood,adipose tissue,intestine,heart,liver,spleen,lungs,kidneys,brain,spinal cord,bone marrow,and bones.ExerGeneDB features bulk ribonucleic acid sequencing(RNA-seq)(including non-coding RNA(ncRNA)and protein-coding RNA),microarray(including ncRNA and protein-coding RNA),and single cell RNA-seq data.Conclusion:ExerGeneDB compiles and re-analyzes exercise-related data with a focus on clinical information.This has culminated in the crea-tion of an interactive database for exercise regulation genes.The website for ExerGeneDB can be found at:https://exergenedb.com.展开更多
Subjective well-being is a key indicator of quality of life and a crucial factor for successful aging among older adults.However,few studies have explored the subjective well-being among older adults from the perspect...Subjective well-being is a key indicator of quality of life and a crucial factor for successful aging among older adults.However,few studies have explored the subjective well-being among older adults from the perspective of digital literacy.Therefore,this study explores the relationship between digital literacy and subjective well-being using data on 4270 older adults from the 2020 China Family Panel Studies(CFPS)dataset.PROCESS mediation analysis results indicated digital literacy is associated with higher subjective well-being among the older adults.Digital literacy was associated with the frequency of physical exercise and consumption.Moreover,Digital literacy can also enhance the subjective well-being among older adults by increasing the frequency of physical exercise,and consumption,and a chain mediator subjective well-being.These findings align with the theoretical framework of digital health literacy.Theory which posits that health information obtained through digital literacy can help older adults better engage in healthy lifestyles,thereby enhancing their quality of life.These findings hold significant practical implications for enhancing the subjective well-being among older adults and advancing the development of successful aging.展开更多
Purpose: The purpose of this umbrella review was to synthesize the evidence from systematic reviews on the benefits and harms of exercise therapy and physical activity(PA) for the secondary prevention and management o...Purpose: The purpose of this umbrella review was to synthesize the evidence from systematic reviews on the benefits and harms of exercise therapy and physical activity(PA) for the secondary prevention and management of low back pain(LBP).Methods: An umbrella review was conducted to evaluate the effectiveness of exercise therapy and PA in the management and secondary prevention of LBP. A systematic search was performed in MEDLINE, CINAHL, Scopus, Web of Science, Cochrane Database of Systematic Reviews,and Physiotherapy Evidence Database(PEDro), including reference lists of relevant reviews, covering studies published between January 1,2010 and May 20, 2024. Eligible studies were systematic reviews of randomized controlled trials and observational studies, with or without meta-analyses. The primary outcome for secondary prevention was LBP recurrence, while for management, primary outcomes included pain intensity and disability, with adverse events as secondary outcomes. Data were extracted across immediate, short-term, intermediate, and longterm follow-up periods. The Grading of Recommendations Assessment, Development, and Evaluation(GRADE) framework was used to assess the certainty of evidence, and the Assessment of Multiple Systematic Reviews tool(AMSTAR) tool was applied by 2 independent reviewers(JC, QL, and/or DXMW) to evaluate the quality of the included reviews. The study was prospectively registered on the Open Science Framework(OSF).Results: A total of 70 systematic reviews were included, 43 with meta-analyses, 7 with network meta-analyses, and 20 without meta-analyses.Six(out of 10) reviews with meta-analyses for secondary prevention indicated a small benefit from general exercises and leisure-time PA(low-to-moderate certainty). For LBP management, 35(out of 36) reviews reported that exercise therapies such as Pilates, motor control,mixed exercise, Tai Chi, water-based exercises, and yoga showed small beneficial effects on pain and disability compared to minimal intervention mainly in the short-term(low-to-moderate certainty). Seven network meta-analyses favored motor control and Pilates over other forms of exercise to reduce pain(low certainty). Adverse events were reported in less than 31% of the reviews, predominantly involving postexercise soreness and temporary increases in pain, mainly in yoga-related studies. Adverse events were considered minor, and no serious adverse events were reported.Conclusion: There is low-to-moderate certainty that exercise therapy and leisure-time PA are beneficial for improving pain and preventing the recurrence of LBP. However, evidence on the potential harms of these interventions is limited, and adverse events related to exercise and PA remain under-investigated.展开更多
Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally.Physical exercise,as an effective strategy for improving general health,has been largely reported for it...Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally.Physical exercise,as an effective strategy for improving general health,has been largely reported for its effectiveness in slowing neurodegeneration and increasing brain functional plasticity,particularly in aging brains.However,the underlying mechanisms of exercise in cognitive aging remain largely unclear.Adiponectin,a cell-secreted protein hormone,has recently been found to regulate synaptic plasticity and mediate the antidepressant effects of physical exercise.Studies on the neuroprotective effects of adiponectin have revealed potential innovative treatments for Alzheimer's disease.Here,we reviewed the functions of adiponectin and its receptor in the brains of human and animal models of cognitive impairment.We summarized the role of adiponectin in Alzheimer's disease,focusing on its impact on energy metabolism,insulin resistance,and inflammation.We also discuss how exercise increases adiponectin secretion and its potential benefits for learning and memory.Finally,we highlight the latest research on chemical compounds that mimic exerciseenhanced secretion of adiponectin and its receptor in Alzheimer's disease.展开更多
The prevalence of high blood pressure is on the rise among younger individuals,and recent findings have linked exercise to changes in the diversity and configuration of gut microbiota.However,specific modifications to...The prevalence of high blood pressure is on the rise among younger individuals,and recent findings have linked exercise to changes in the diversity and configuration of gut microbiota.However,specific modifications to one's diet,such as incorporating blueberries while engaging in physical activity,can also influence this association.To explore the effects of exercise and blueberry consumption on gut bacteria,we conducted an 8-week study involving healthy and hypertensive college students.Our microbiome analysis revealed slight shifts in gut bacteria composition in response to increased physical activity,with significant changes in the diversity of the g_[Eubacterium]_eligens_group observed in hypertensive college students who regularly consumed blueberries.Although exercise and blueberry supplementation had a negligible impact on the gut microbiota diversity of healthy college students,it significantly boosted the production of butyric acid bacteria in hypertensive young adults.These results suggest that the changes in gut bacteria variety and abundance brought about by blueberries may be tied to alterations in the body composition of patients with hypertension.This study aims to reveal the impact of blueberry on the hypertensive students from a unique perspective,suggesting the impact of taking blueberry while taking exercises.展开更多
Non-alcoholic fatty liver disease(NAFLD)without special drugs shows symptoms of liver fat accumulation and steatosis in patients without alcohol intake.Ultrasound evaluation is a critical method in the early diagnosis...Non-alcoholic fatty liver disease(NAFLD)without special drugs shows symptoms of liver fat accumulation and steatosis in patients without alcohol intake.Ultrasound evaluation is a critical method in the early diagnosis of NAFLD stages as well as image processing and should be encouraged.Olive oil is an important component of the Mediterranean diet and has a beneficial role in the prevention of NAFLD progression.Physical activity and exercise can have anti-oxidant and anti-inflammatory effects to reduce liver fat and body weight via regulation of mitochondrial capacity in the development of NAFLD.Both the Mediterranean diet and physical exercise should be combined to achieve the ideal fat content reduction and weight loss in patients with NAFLD.展开更多
Physical exercise is recognized as an effective intervention to improve mood,physical performance,and general well-being.It achieves these benefits through cellular and molecular mechanisms that promote the release of...Physical exercise is recognized as an effective intervention to improve mood,physical performance,and general well-being.It achieves these benefits through cellular and molecular mechanisms that promote the release of neuroprotective factors.Interestingly,reduced levels of physical exercise have been implicated in several central nervous system diseases,including ocular disorders.Emerging evidence has suggested that physical exercise levels are significantly lower in individuals with ocular diseases such as glaucoma,age-related macular degeneration,retinitis pigmentosa,and diabetic retinopathy.Physical exercise may have a neuroprotective effect on the retina.Therefore,the association between reduced physical exercise and ocular diseases may involve a bidirectional causal relationship whereby visual impairment leads to reduced physical exercise and decreased exercise exacerbates the development of ocular disease.In this review,we summarize the evidence linking physical exercise to eye disease and identify potential mediators of physical exercise-induced retinal neuroprotection.Finally,we discuss future directions for preclinical and clinical research in exercise and eye health.展开更多
Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are obscure.Immunometabolic regulation has emerged as one ...Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are obscure.Immunometabolic regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.展开更多
As mental health issues among adolescents receive increasing attention,the impact of physical exercise on mental health has become prominent.In this paper,junior high school students in Luoding County and Yunan County...As mental health issues among adolescents receive increasing attention,the impact of physical exercise on mental health has become prominent.In this paper,junior high school students in Luoding County and Yunan County of Yunfu are taken as participants.It employs a convenient sampling method to distribute questionnaires,utilizes relevant scales for measurement,and analyzes the data with the assistance of SPSS 26.0.The results indicate a significantly negative correlation between physical exercise and social anxiety.Overall,junior high school students in this region engage in relatively weak physical exercise,and their social anxiety is at a moderate level,with female students being more prone to anxiety.Left-behind children exhibit higher levels of social anxiety compared to non-left-behind children.There are notable differences among group characteristics,with social and cultural factors and physiological factors influencing gender differences,and the lack of family support affecting the social anxiety of left-behind children.This study provides a basis for intervening in psychological anxiety and other issues.It is suggested deepening the sports collaborative education mechanism,paying attention to the cultivation of social and emotional abilities of left-behind children,and using physical exercise to promote the development of students social adaptability.展开更多
New media is becoming an important method to promote physical exercise,and it is also an essential factor affecting the physical exercise behavior of college students.This study takes the influence of new media sports...New media is becoming an important method to promote physical exercise,and it is also an essential factor affecting the physical exercise behavior of college students.This study takes the influence of new media sports information on college students’physical exercise behavior as the research objective.By using a questionnaire survey and mathematical statistics,545 college students in Shandong Province of China are selected as research samples.Based on the theory of new media exposure,fitness behavior theory,and self-efficacy theory,this study systematically discusses the influence and mechanism of new media exposure on the physical exercise behavior of college students in Shandong Province,so as to help college students improve their physical exercise behavior.展开更多
Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiqu...Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.展开更多
Background:A shift from self-reports to wearable sensors for global physical activity(PA)surveillance has been recommended.The conventional use of a generic cut-point to assess moderate-to-vigorous PA(MVPA)is problema...Background:A shift from self-reports to wearable sensors for global physical activity(PA)surveillance has been recommended.The conventional use of a generic cut-point to assess moderate-to-vigorous PA(MVPA)is problematic as these cut-points are often derived from non-representative samples under non-ecological laboratory conditions.This study aimed to develop age-and sex-(age-sex)specific cut-points for MVPA based on population-standardized values as a feasible approach to assess the adherence to PA guidelines and to investigate its associations with all-cause mortality.Methods:A total of 7601 participants(20-85+years)were drawn from the 2003-2004 and 2005-2006 National Health and Nutrition Examination Surveys(NHANES).Minutes per week of MVPA were assessed with a hip-worn accelerometer.Counts per minute(CPM)were used to define an age-sex specific target intensity,representing the intensity each person should be able to reach based on their age and sex.Age-sex specific MVPA cut-points were defined as any activity above 40%of the target intensity.These population-and free-living-based age-sex specific cut-points overcome many of the limitations of the standard generic cut-point approach.For comparison,we also calculated MVPA with a generic cut-point of 1952 CPM.Both approaches were compared for assessing adherence to PA guidelines and association of MVPA with allcause mortality(ascertained through December 2015).Results:Both approaches indicated that 37%of the sample met the 150+min/week guideline.The generic cut-point approach showed a trend to inactivity with age,which was less pronounced using the age-sex specific cut-points.Overall mortality rates were comparable using generic cutpoint(hazard ratio(HR)=0.61,95%confidence interval(95%CI):0.50-0.73)or age-sex specific cut-points(HR=0.57,95%CI:0.50-0.66)for the entire sample.The generic cut-point method revealed an age-and sex-related gap in the benefits of achieving 150+min/week of MVPA,with older adults showing an 18%greater reduction in mortality rates than younger adults,and a larger difference in women than in men.This disparity disappeared when using age-sex specific cut-points.Conclusion:Our findings underscore the value of age-sex specific cut-points for global PA surveillance.MVPA defined with age-sex specific thresholds was associated with all-cause mortality and the dose-response was similar for all ages and sexes.This aligns with the single recommendation of accumulating 150+min/week MVPA for all adults,irrespective of age and sex.This study serves as a proof of concept to develop this methodology for PA surveillance over more advanced open-source acceleration metrics and other national and international cohorts.展开更多
Background:Physical inactivity among adolescents has become a global public health challenge,with over 80%failing to meet the recommendations of the WHO for activity levels.Existing research predominantly examines how...Background:Physical inactivity among adolescents has become a global public health challenge,with over 80%failing to meet the recommendations of the WHO for activity levels.Existing research predominantly examines how physical activity(PA)enhances resilience,while the predictive role of resilience in PA,particularly its interaction with family factors,has received limited attention.This study aimed to examine the associations between resilience and PA among adolescents,focusing on family functioning and gender differences.Methods:In this cross-sectional study,a total of 909 Chinese adolescents(463 males and 446 females,aged 13.30.5 years)completed the±following validated self-report instruments:the Connor-Davidson Resilience Scale with 10 items,the Physical Activity Questionnaire for Older Children,and the Family Adaptability and Cohesion Evaluation Scale II-Chinese version that was used to categorize family functioning into three types(i.e.,lower,balanced,and higher).The generalized linear mixed-effect model(GLMM)was used to determine the contribution of resilience and its interaction with family functioning type on PA after adjusting for age and gender.Results:Males presented significantly higher resilience and PA levels(both p 0.001)as well as better family functioning(p 0.01)than females.Compared with the lower<<functioning group,participants from higher-functioning families showed superior resilience and PA(both p 0.001).<The GLMM analysis revealed a positive relationship between resilience and PA(p 0.001),where the lower functioning<group was significantly weaker than the higher functioning group.Conclusion:Resilience and PA in adolescents vary across gender and family functioning type,with males and adolescents from better-functioning families outperforming their peers.Resilience is a positive predictor of PA in adolescents,with family functioning type being a crucial moderator of such a relationship.展开更多
A growing global trend indicates a decline in semen quality,with a lack of physical activity identified as one of the contributing factors.Exercise is medication,and numerous studies have explored its effects on semen...A growing global trend indicates a decline in semen quality,with a lack of physical activity identified as one of the contributing factors.Exercise is medication,and numerous studies have explored its effects on semen quality.However,there is no consensus on the most effective type and intensity of exercise for improving semen quality,owing to inconsistent findings across studies.These discrepancies may be attributable to variations in study populations(e.g.,healthy versus infertile individuals)and research methodologies(e.g.,observational versus interventional studies).This paper reviews the existing literature from the databases PubMed,Web of Science,and Google Scholar,reclassifying articles on their subject and research designs to delineate the relationship between exercise and semen quality.It also summarizes the mechanisms through which exercise influences semen quality,including hormonal regulation,oxidative stress,and inflammatory factors.展开更多
Exercise is established as a supportive care intervention during and after various cancer treatment modalities.1,2 Documented benefits include improvements in health-related fitness,physical functioning,some symptoms/...Exercise is established as a supportive care intervention during and after various cancer treatment modalities.1,2 Documented benefits include improvements in health-related fitness,physical functioning,some symptoms/side effects,psychosocial functioning,and quality of life.1,2 Exercise has not been established,however,as a treatment for any type of cancer in any clinical oncology setting.2 This special topic of the Journal of Sport and Health Science(JSHS)is dedicated to research on“Exercise as a cancer treatment”.The special topic sought preclinical,observational,or clinical studies examining the effects of exercise after a cancer diagnosis on a cancer outcome(e.g.,cell/tumor growth,tumor response,disease recurrence,progression,death from cancer).It includes 6 original articles and an invited opinion article.展开更多
Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog- nized for its therapeutic eff...Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog- nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro- genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counter- acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.展开更多
Physical exercise can minimize dysfunction and optimize functional motor recovery after stroke by modulating cortical plasticity.However,the limitation of physical exercise is that large amounts of time and effort are...Physical exercise can minimize dysfunction and optimize functional motor recovery after stroke by modulating cortical plasticity.However,the limitation of physical exercise is that large amounts of time and effort are necessary to significantly improve motor function,and even then,substantial exercise may not be sufficient to normalize the observed improvements.Thus,interventions that could be used to strengthen physical exercise-induced neuroplasticity may be valuable in treating hemiplegia after stroke.Repetitive transcranial magnetic stimulation seems to be a viable strategy for enhancing such plasticity.As a non-invasive cortical stimulation technique,repetitive transcranial magnetic stimulation is able to induce longterm plastic changes in the motor system.Recently,repetitive transcranial magnetic stimulation was found to optimize the plastic changes caused by motor training,thereby enhancing the long-term effects of physical exercise in stroke patients.Therefore,it is believed that the combination of repetitive transcranial magnetic stimulation and physical exercise may represent a superior method for restoring motor function after stroke.展开更多
Exercise can enhance motivation to change lifestyle behaviors,improve aerobic fitness,improve physical function,control fatigue,and enhance quality of life.Studies have demonstrated the benefits to be gained from phys...Exercise can enhance motivation to change lifestyle behaviors,improve aerobic fitness,improve physical function,control fatigue,and enhance quality of life.Studies have demonstrated the benefits to be gained from physical exercise,highlighting the importance of popularizing the concept of physical exercise for individuals and making professional exercise-treatment programs available to patients with cancer.However,the correlation between physical exercise and carcinogenesis is easily overlooked,and exercise interventions are not routinely provided to patients with cancer,especially those with advanced cancer.In this article,we present a literature review of the effects of exercise on cancer development and progression and give recent evidence for the type of exercise best suited for different types of cancer and in different disease stages.Moreover,the molecular mechanisms about regulating metabolism and systemic immune function in cancer are summarized and discussed.In conclusion,physical exercise should be considered as an important intervention for preventing and treating cancer and its complications.展开更多
The many important benefits of physical exercise also encompass maintenance or improvement of cognitive functions. Among the variousmechanisms underlying the association between physical exercise and brain health, rec...The many important benefits of physical exercise also encompass maintenance or improvement of cognitive functions. Among the variousmechanisms underlying the association between physical exercise and brain health, recent evidence attests that neurotrophin receptor signalingmay have an important role, because the activation of this pathway leads to growth and differentiation of new neurons and synapses, supportsaxonal and dendritic growth, fosters synaptic plasticity, and preserves survival of existing neurons. In this review of published evidence, we highlightthat a positive relationship exists between physical exercise and circulating brain-derived neurotrophic factor levels and that the postexercisevariation of this molecule is associated with improvement of neurocognitive functioning. Less clear evidence has instead been published forother neurotrophins, such as nerve growth factor, neurotrophin-3, and neurotrophin-4. Overall, promotion of adequate volumes and intensities ofphysical exercise (i.e., approximately 3 months of moderate-intensity aerobic exercise, with 2—3 sessions/week lasting not less than 30 min)may hence be regarded as an inexpensive and safe strategy for boosting brain-derived neurotrophic factor release, thus preserving or restoringcognitive functions.展开更多
This study aims at investigating the in-depth information regarding impacts of physical exercise on psychological well-being in university students with an emphasis on coping with stress in the context of leisure. A q...This study aims at investigating the in-depth information regarding impacts of physical exercise on psychological well-being in university students with an emphasis on coping with stress in the context of leisure. A qualitative research, based on interview to draw findings in an inductive way, was conducted. Nine university students (N = 9) in a large mid-west university took part in a face- to face, semi-structured interviews using ten open-ended questions with respect to benefits of leisure time physical exercise. The interview on the basis of phenomenological research examined what the participants experienced with leisure time physical exercise in conjunction with stress coping and mental health. Meaningful units of themes were induced with 24 initially drawn themes. These themes were reduced to 8 comprehensive constituent themes: self-efficacy, positive emotion, mind and body, health-behaviors, self-esteem, leisure, problem-focused coping, and positive expectancy. These reduced themes were finally boiled down to 6 integrated themes: positive emotion, unity of mind and body, heightened self-esteem, leisure, problem-focused coping, and self-regulation of health behavior. This research may shed a light in illuminating potential mechanism of how regular physical exercise is conducive to enhanced health behavior as well as effective stress coping in university students in the context of leisure. In particular, this research appears to be meaningful in suggesting that regular leisure-time physical exercise can lead to an effective problem-focused coping through elicitation of positive emotion.展开更多
基金supported by grants from the National Natural Science Foundation of China(82225005, 82020108002 to JX,82200321 to QZ)Science and Technology Commission of ShanghaiMunicipality(23410750100,20DZ2255400,, 21XD1421300 to JX)+1 种基金the“Dawn”Program of Shanghai Educa-tion Commission(19SG34 to JX)Shanghai Sailing Program(21YF1413200 to QZ).
文摘Background:Exercise induces molecular changes that involve multiple organs and tissues.Moreover,these changes are modulated by various exercise parameters—such as intensity,frequency,mode,and duration—as well as by clinical features like gender,age,and body mass index(BMI),each eliciting distinct biological effects.To assist exercise researchers in understanding these changes from a comprehensive perspective that includes multiple organs,diverse exercise regimens,and a range of clinical features,we developed Exercise Regulated Genes Database(ExerGeneDB),a database of exercise-regulated differential genes.Methods:ExerGeneDB aggregated publicly available exercise-related sequencing datasets and subjected them to uniform quality control and preprocessing.The data,encompassing a variety of types,were organized into a specialized database of exercise-regulated genes.Notably,Exer-GeneDB conducted differential analyses on this collected data,leveraging curated clinical information and accounting for important factors such as gender,age,and BMI.Results:ExerGeneDB has assembled 1692 samples from rats and mice as well as 4492 human samples.It contains data from various tissues and organs,such as skeletal muscle,blood,adipose tissue,intestine,heart,liver,spleen,lungs,kidneys,brain,spinal cord,bone marrow,and bones.ExerGeneDB features bulk ribonucleic acid sequencing(RNA-seq)(including non-coding RNA(ncRNA)and protein-coding RNA),microarray(including ncRNA and protein-coding RNA),and single cell RNA-seq data.Conclusion:ExerGeneDB compiles and re-analyzes exercise-related data with a focus on clinical information.This has culminated in the crea-tion of an interactive database for exercise regulation genes.The website for ExerGeneDB can be found at:https://exergenedb.com.
文摘Subjective well-being is a key indicator of quality of life and a crucial factor for successful aging among older adults.However,few studies have explored the subjective well-being among older adults from the perspective of digital literacy.Therefore,this study explores the relationship between digital literacy and subjective well-being using data on 4270 older adults from the 2020 China Family Panel Studies(CFPS)dataset.PROCESS mediation analysis results indicated digital literacy is associated with higher subjective well-being among the older adults.Digital literacy was associated with the frequency of physical exercise and consumption.Moreover,Digital literacy can also enhance the subjective well-being among older adults by increasing the frequency of physical exercise,and consumption,and a chain mediator subjective well-being.These findings align with the theoretical framework of digital health literacy.Theory which posits that health information obtained through digital literacy can help older adults better engage in healthy lifestyles,thereby enhancing their quality of life.These findings hold significant practical implications for enhancing the subjective well-being among older adults and advancing the development of successful aging.
基金funded by the Medical Research Future Fund-MRFF 2019 (Rapid Applied Research TranslationRART award)funded by an Australian Government Research Training Program Scholarship-RTP+1 种基金funded by National Health and Medical Research Council of Australia Research Fellowshipsfunded by the National Health and Medical Research Council (NHMRC) Leadership Fellow level 2
文摘Purpose: The purpose of this umbrella review was to synthesize the evidence from systematic reviews on the benefits and harms of exercise therapy and physical activity(PA) for the secondary prevention and management of low back pain(LBP).Methods: An umbrella review was conducted to evaluate the effectiveness of exercise therapy and PA in the management and secondary prevention of LBP. A systematic search was performed in MEDLINE, CINAHL, Scopus, Web of Science, Cochrane Database of Systematic Reviews,and Physiotherapy Evidence Database(PEDro), including reference lists of relevant reviews, covering studies published between January 1,2010 and May 20, 2024. Eligible studies were systematic reviews of randomized controlled trials and observational studies, with or without meta-analyses. The primary outcome for secondary prevention was LBP recurrence, while for management, primary outcomes included pain intensity and disability, with adverse events as secondary outcomes. Data were extracted across immediate, short-term, intermediate, and longterm follow-up periods. The Grading of Recommendations Assessment, Development, and Evaluation(GRADE) framework was used to assess the certainty of evidence, and the Assessment of Multiple Systematic Reviews tool(AMSTAR) tool was applied by 2 independent reviewers(JC, QL, and/or DXMW) to evaluate the quality of the included reviews. The study was prospectively registered on the Open Science Framework(OSF).Results: A total of 70 systematic reviews were included, 43 with meta-analyses, 7 with network meta-analyses, and 20 without meta-analyses.Six(out of 10) reviews with meta-analyses for secondary prevention indicated a small benefit from general exercises and leisure-time PA(low-to-moderate certainty). For LBP management, 35(out of 36) reviews reported that exercise therapies such as Pilates, motor control,mixed exercise, Tai Chi, water-based exercises, and yoga showed small beneficial effects on pain and disability compared to minimal intervention mainly in the short-term(low-to-moderate certainty). Seven network meta-analyses favored motor control and Pilates over other forms of exercise to reduce pain(low certainty). Adverse events were reported in less than 31% of the reviews, predominantly involving postexercise soreness and temporary increases in pain, mainly in yoga-related studies. Adverse events were considered minor, and no serious adverse events were reported.Conclusion: There is low-to-moderate certainty that exercise therapy and leisure-time PA are beneficial for improving pain and preventing the recurrence of LBP. However, evidence on the potential harms of these interventions is limited, and adverse events related to exercise and PA remain under-investigated.
基金supported by the National Natural Science Foundation of China,No.82072529(to HWHT)Key Laboratory of Guangdong Higher Education Institutes,No.2021KSYS009(to HWHT)the China Postdoctoral Science Foundation,No.2022M720907(to HHG)。
文摘Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally.Physical exercise,as an effective strategy for improving general health,has been largely reported for its effectiveness in slowing neurodegeneration and increasing brain functional plasticity,particularly in aging brains.However,the underlying mechanisms of exercise in cognitive aging remain largely unclear.Adiponectin,a cell-secreted protein hormone,has recently been found to regulate synaptic plasticity and mediate the antidepressant effects of physical exercise.Studies on the neuroprotective effects of adiponectin have revealed potential innovative treatments for Alzheimer's disease.Here,we reviewed the functions of adiponectin and its receptor in the brains of human and animal models of cognitive impairment.We summarized the role of adiponectin in Alzheimer's disease,focusing on its impact on energy metabolism,insulin resistance,and inflammation.We also discuss how exercise increases adiponectin secretion and its potential benefits for learning and memory.Finally,we highlight the latest research on chemical compounds that mimic exerciseenhanced secretion of adiponectin and its receptor in Alzheimer's disease.
基金funded by the Liaoning province Department of Education fund(LJKZ0651)the scientific research fund project of Liaoning provincial department of education(LJKZ0430)the Fund for Distinguished Young Scholars of Liaoning Province(2023JH6/100500010)。
文摘The prevalence of high blood pressure is on the rise among younger individuals,and recent findings have linked exercise to changes in the diversity and configuration of gut microbiota.However,specific modifications to one's diet,such as incorporating blueberries while engaging in physical activity,can also influence this association.To explore the effects of exercise and blueberry consumption on gut bacteria,we conducted an 8-week study involving healthy and hypertensive college students.Our microbiome analysis revealed slight shifts in gut bacteria composition in response to increased physical activity,with significant changes in the diversity of the g_[Eubacterium]_eligens_group observed in hypertensive college students who regularly consumed blueberries.Although exercise and blueberry supplementation had a negligible impact on the gut microbiota diversity of healthy college students,it significantly boosted the production of butyric acid bacteria in hypertensive young adults.These results suggest that the changes in gut bacteria variety and abundance brought about by blueberries may be tied to alterations in the body composition of patients with hypertension.This study aims to reveal the impact of blueberry on the hypertensive students from a unique perspective,suggesting the impact of taking blueberry while taking exercises.
基金Supported by the Natural Science Foundation of Shanghai,No.17ZR1431400National Key Research and Development Program of China,No.2017YFA0103902.
文摘Non-alcoholic fatty liver disease(NAFLD)without special drugs shows symptoms of liver fat accumulation and steatosis in patients without alcohol intake.Ultrasound evaluation is a critical method in the early diagnosis of NAFLD stages as well as image processing and should be encouraged.Olive oil is an important component of the Mediterranean diet and has a beneficial role in the prevention of NAFLD progression.Physical activity and exercise can have anti-oxidant and anti-inflammatory effects to reduce liver fat and body weight via regulation of mitochondrial capacity in the development of NAFLD.Both the Mediterranean diet and physical exercise should be combined to achieve the ideal fat content reduction and weight loss in patients with NAFLD.
基金supported by the InnoHK Initiative and the Hong Kong Special Administrative Region Government, China (to SYY)。
文摘Physical exercise is recognized as an effective intervention to improve mood,physical performance,and general well-being.It achieves these benefits through cellular and molecular mechanisms that promote the release of neuroprotective factors.Interestingly,reduced levels of physical exercise have been implicated in several central nervous system diseases,including ocular disorders.Emerging evidence has suggested that physical exercise levels are significantly lower in individuals with ocular diseases such as glaucoma,age-related macular degeneration,retinitis pigmentosa,and diabetic retinopathy.Physical exercise may have a neuroprotective effect on the retina.Therefore,the association between reduced physical exercise and ocular diseases may involve a bidirectional causal relationship whereby visual impairment leads to reduced physical exercise and decreased exercise exacerbates the development of ocular disease.In this review,we summarize the evidence linking physical exercise to eye disease and identify potential mediators of physical exercise-induced retinal neuroprotection.Finally,we discuss future directions for preclinical and clinical research in exercise and eye health.
基金This work was supported by the National Natural Science Foundation of China(82172511)the Natural Science Foundation of Jiangsu Province(BK20210068)+4 种基金the Sanming Project of Medicine in Shenzhen(SZSM201612078)the Health Shanghai Initiative Special Fund[Medical-Sports Integration(JKSHZX-2022-02)]the Top Talent Support Program for Young-and Middle-aged People of Wuxi Municipal Health Commission(HB2020003)the Mega-project of Wuxi Commission of Health(Z202216)the High-end Medical Expert Team of the 2019 Taihu Talent Plan(2019-THRCTD-1)
文摘Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are obscure.Immunometabolic regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.
基金Supported by Zhaoqing Philosophy and Social Sciences Planning Office Project(19ZC-19)Research and Practice Project of Promoting the High-quality Development of Basic Education by the Construction of New Normal School in 2023Key Research Platforms and Project Proposals for Ordinary Universities in 2022(2022ZDZX4058).
文摘As mental health issues among adolescents receive increasing attention,the impact of physical exercise on mental health has become prominent.In this paper,junior high school students in Luoding County and Yunan County of Yunfu are taken as participants.It employs a convenient sampling method to distribute questionnaires,utilizes relevant scales for measurement,and analyzes the data with the assistance of SPSS 26.0.The results indicate a significantly negative correlation between physical exercise and social anxiety.Overall,junior high school students in this region engage in relatively weak physical exercise,and their social anxiety is at a moderate level,with female students being more prone to anxiety.Left-behind children exhibit higher levels of social anxiety compared to non-left-behind children.There are notable differences among group characteristics,with social and cultural factors and physiological factors influencing gender differences,and the lack of family support affecting the social anxiety of left-behind children.This study provides a basis for intervening in psychological anxiety and other issues.It is suggested deepening the sports collaborative education mechanism,paying attention to the cultivation of social and emotional abilities of left-behind children,and using physical exercise to promote the development of students social adaptability.
文摘New media is becoming an important method to promote physical exercise,and it is also an essential factor affecting the physical exercise behavior of college students.This study takes the influence of new media sports information on college students’physical exercise behavior as the research objective.By using a questionnaire survey and mathematical statistics,545 college students in Shandong Province of China are selected as research samples.Based on the theory of new media exposure,fitness behavior theory,and self-efficacy theory,this study systematically discusses the influence and mechanism of new media exposure on the physical exercise behavior of college students in Shandong Province,so as to help college students improve their physical exercise behavior.
基金supported by Project of the Health Shanghai Initiative Special Fund(Medical-Sports Integration,Creating a New Model of Exercise for Health),No.JKSHZX-2022-02(to SC).
文摘Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.
基金supported in part by the intramural research programs at the National Institute on Aging and National Cancer Institute(USA)supported by the Spanish Ministry of Science,Innovation and Universities under Beatriz Galindo's 2022 fellowship program(BG22/00075).
文摘Background:A shift from self-reports to wearable sensors for global physical activity(PA)surveillance has been recommended.The conventional use of a generic cut-point to assess moderate-to-vigorous PA(MVPA)is problematic as these cut-points are often derived from non-representative samples under non-ecological laboratory conditions.This study aimed to develop age-and sex-(age-sex)specific cut-points for MVPA based on population-standardized values as a feasible approach to assess the adherence to PA guidelines and to investigate its associations with all-cause mortality.Methods:A total of 7601 participants(20-85+years)were drawn from the 2003-2004 and 2005-2006 National Health and Nutrition Examination Surveys(NHANES).Minutes per week of MVPA were assessed with a hip-worn accelerometer.Counts per minute(CPM)were used to define an age-sex specific target intensity,representing the intensity each person should be able to reach based on their age and sex.Age-sex specific MVPA cut-points were defined as any activity above 40%of the target intensity.These population-and free-living-based age-sex specific cut-points overcome many of the limitations of the standard generic cut-point approach.For comparison,we also calculated MVPA with a generic cut-point of 1952 CPM.Both approaches were compared for assessing adherence to PA guidelines and association of MVPA with allcause mortality(ascertained through December 2015).Results:Both approaches indicated that 37%of the sample met the 150+min/week guideline.The generic cut-point approach showed a trend to inactivity with age,which was less pronounced using the age-sex specific cut-points.Overall mortality rates were comparable using generic cutpoint(hazard ratio(HR)=0.61,95%confidence interval(95%CI):0.50-0.73)or age-sex specific cut-points(HR=0.57,95%CI:0.50-0.66)for the entire sample.The generic cut-point method revealed an age-and sex-related gap in the benefits of achieving 150+min/week of MVPA,with older adults showing an 18%greater reduction in mortality rates than younger adults,and a larger difference in women than in men.This disparity disappeared when using age-sex specific cut-points.Conclusion:Our findings underscore the value of age-sex specific cut-points for global PA surveillance.MVPA defined with age-sex specific thresholds was associated with all-cause mortality and the dose-response was similar for all ages and sexes.This aligns with the single recommendation of accumulating 150+min/week MVPA for all adults,irrespective of age and sex.This study serves as a proof of concept to develop this methodology for PA surveillance over more advanced open-source acceleration metrics and other national and international cohorts.
基金supported by the National Social Science Fund of China(Grant No.22BTY098)with JJY as Principal Investigator.
文摘Background:Physical inactivity among adolescents has become a global public health challenge,with over 80%failing to meet the recommendations of the WHO for activity levels.Existing research predominantly examines how physical activity(PA)enhances resilience,while the predictive role of resilience in PA,particularly its interaction with family factors,has received limited attention.This study aimed to examine the associations between resilience and PA among adolescents,focusing on family functioning and gender differences.Methods:In this cross-sectional study,a total of 909 Chinese adolescents(463 males and 446 females,aged 13.30.5 years)completed the±following validated self-report instruments:the Connor-Davidson Resilience Scale with 10 items,the Physical Activity Questionnaire for Older Children,and the Family Adaptability and Cohesion Evaluation Scale II-Chinese version that was used to categorize family functioning into three types(i.e.,lower,balanced,and higher).The generalized linear mixed-effect model(GLMM)was used to determine the contribution of resilience and its interaction with family functioning type on PA after adjusting for age and gender.Results:Males presented significantly higher resilience and PA levels(both p 0.001)as well as better family functioning(p 0.01)than females.Compared with the lower<<functioning group,participants from higher-functioning families showed superior resilience and PA(both p 0.001).<The GLMM analysis revealed a positive relationship between resilience and PA(p 0.001),where the lower functioning<group was significantly weaker than the higher functioning group.Conclusion:Resilience and PA in adolescents vary across gender and family functioning type,with males and adolescents from better-functioning families outperforming their peers.Resilience is a positive predictor of PA in adolescents,with family functioning type being a crucial moderator of such a relationship.
基金supported by the Emerging Interdisciplinary Platform for Medicine and Engineering in Sports(EIPMES)and R&D Program of Beijing Municipal Education Commission(grant No.KM202310029001).
文摘A growing global trend indicates a decline in semen quality,with a lack of physical activity identified as one of the contributing factors.Exercise is medication,and numerous studies have explored its effects on semen quality.However,there is no consensus on the most effective type and intensity of exercise for improving semen quality,owing to inconsistent findings across studies.These discrepancies may be attributable to variations in study populations(e.g.,healthy versus infertile individuals)and research methodologies(e.g.,observational versus interventional studies).This paper reviews the existing literature from the databases PubMed,Web of Science,and Google Scholar,reclassifying articles on their subject and research designs to delineate the relationship between exercise and semen quality.It also summarizes the mechanisms through which exercise influences semen quality,including hormonal regulation,oxidative stress,and inflammatory factors.
基金supported by the Canada Research Chairs Programa Foundation Grant from the Canadian Institutes of Health Research (No. 159927)
文摘Exercise is established as a supportive care intervention during and after various cancer treatment modalities.1,2 Documented benefits include improvements in health-related fitness,physical functioning,some symptoms/side effects,psychosocial functioning,and quality of life.1,2 Exercise has not been established,however,as a treatment for any type of cancer in any clinical oncology setting.2 This special topic of the Journal of Sport and Health Science(JSHS)is dedicated to research on“Exercise as a cancer treatment”.The special topic sought preclinical,observational,or clinical studies examining the effects of exercise after a cancer diagnosis on a cancer outcome(e.g.,cell/tumor growth,tumor response,disease recurrence,progression,death from cancer).It includes 6 original articles and an invited opinion article.
基金supported by Hong Kong Health and Medical Research FundLeading Talents of Guangdong(2013)+3 种基金Programme of Introducing Talents of Discipline to Universities(B14036)Project of International,as well as Hong Kong,Macao&Taiwan Science and Technology Cooperation Innovation Platform in Universities in Guangdong Province,China(2013gjhz0002)grants to Jinan University Guangdong-Hong Kong-Macao Cooperation and Innovation Center for Tissue Regeneration and RepairState Key Laboratory of Pharmaceutical Biotechnology,Hong Kong SAR,China
文摘Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog- nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro- genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counter- acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.
基金supported by the Shanghai Jiao Tong University School of Medicine-Institute of Neuroscience,Chinese Academy of SciencesLeading Startup Project of Brain Diseases Clinical Research Center of China,No.2017NKX002(to QX)。
文摘Physical exercise can minimize dysfunction and optimize functional motor recovery after stroke by modulating cortical plasticity.However,the limitation of physical exercise is that large amounts of time and effort are necessary to significantly improve motor function,and even then,substantial exercise may not be sufficient to normalize the observed improvements.Thus,interventions that could be used to strengthen physical exercise-induced neuroplasticity may be valuable in treating hemiplegia after stroke.Repetitive transcranial magnetic stimulation seems to be a viable strategy for enhancing such plasticity.As a non-invasive cortical stimulation technique,repetitive transcranial magnetic stimulation is able to induce longterm plastic changes in the motor system.Recently,repetitive transcranial magnetic stimulation was found to optimize the plastic changes caused by motor training,thereby enhancing the long-term effects of physical exercise in stroke patients.Therefore,it is believed that the combination of repetitive transcranial magnetic stimulation and physical exercise may represent a superior method for restoring motor function after stroke.
文摘Exercise can enhance motivation to change lifestyle behaviors,improve aerobic fitness,improve physical function,control fatigue,and enhance quality of life.Studies have demonstrated the benefits to be gained from physical exercise,highlighting the importance of popularizing the concept of physical exercise for individuals and making professional exercise-treatment programs available to patients with cancer.However,the correlation between physical exercise and carcinogenesis is easily overlooked,and exercise interventions are not routinely provided to patients with cancer,especially those with advanced cancer.In this article,we present a literature review of the effects of exercise on cancer development and progression and give recent evidence for the type of exercise best suited for different types of cancer and in different disease stages.Moreover,the molecular mechanisms about regulating metabolism and systemic immune function in cancer are summarized and discussed.In conclusion,physical exercise should be considered as an important intervention for preventing and treating cancer and its complications.
基金supported by a postdoctoral contract granted by Subprograma Atraccio de Talent-Contractes Postdoctorals de la Universitat de Valencia
文摘The many important benefits of physical exercise also encompass maintenance or improvement of cognitive functions. Among the variousmechanisms underlying the association between physical exercise and brain health, recent evidence attests that neurotrophin receptor signalingmay have an important role, because the activation of this pathway leads to growth and differentiation of new neurons and synapses, supportsaxonal and dendritic growth, fosters synaptic plasticity, and preserves survival of existing neurons. In this review of published evidence, we highlightthat a positive relationship exists between physical exercise and circulating brain-derived neurotrophic factor levels and that the postexercisevariation of this molecule is associated with improvement of neurocognitive functioning. Less clear evidence has instead been published forother neurotrophins, such as nerve growth factor, neurotrophin-3, and neurotrophin-4. Overall, promotion of adequate volumes and intensities ofphysical exercise (i.e., approximately 3 months of moderate-intensity aerobic exercise, with 2—3 sessions/week lasting not less than 30 min)may hence be regarded as an inexpensive and safe strategy for boosting brain-derived neurotrophic factor release, thus preserving or restoringcognitive functions.
文摘This study aims at investigating the in-depth information regarding impacts of physical exercise on psychological well-being in university students with an emphasis on coping with stress in the context of leisure. A qualitative research, based on interview to draw findings in an inductive way, was conducted. Nine university students (N = 9) in a large mid-west university took part in a face- to face, semi-structured interviews using ten open-ended questions with respect to benefits of leisure time physical exercise. The interview on the basis of phenomenological research examined what the participants experienced with leisure time physical exercise in conjunction with stress coping and mental health. Meaningful units of themes were induced with 24 initially drawn themes. These themes were reduced to 8 comprehensive constituent themes: self-efficacy, positive emotion, mind and body, health-behaviors, self-esteem, leisure, problem-focused coping, and positive expectancy. These reduced themes were finally boiled down to 6 integrated themes: positive emotion, unity of mind and body, heightened self-esteem, leisure, problem-focused coping, and self-regulation of health behavior. This research may shed a light in illuminating potential mechanism of how regular physical exercise is conducive to enhanced health behavior as well as effective stress coping in university students in the context of leisure. In particular, this research appears to be meaningful in suggesting that regular leisure-time physical exercise can lead to an effective problem-focused coping through elicitation of positive emotion.
