BACKGROUND Postoperative anxiety,depression,irritability,and even fear in patients with intertrochanteric femoral fractures may hinder recovery,compromise treatment efficacy,and impede rehabilitation.AIM To investigat...BACKGROUND Postoperative anxiety,depression,irritability,and even fear in patients with intertrochanteric femoral fractures may hinder recovery,compromise treatment efficacy,and impede rehabilitation.AIM To investigate the correlations among anxiety,depression,sense of coherence(SOC),and post-traumatic growth(PTG)in patients who underwent intertrochanteric femoral fracture surgery to improve clinical management strategies and outcomes.METHODS This study carefully selected 211 patients who received surgical treatment for intertrochanteric femoral fractures and were admitted to Dongying People’s Hospital from March 2022 to March 2024.Anxiety and depression in these patients were assessed with the anxiety and depression subscales of the Hospital Anxiety and Depression Scale(HADS),respectively.SOC was evaluated using the 13-item SOC scale(SOC-13),which encompasses three key dimensions:Comprehensibility,manageability,and meaningfulness.PTG was assessed with the Chinese version of PTG Inventory(CPTGI),covering five distinct dimensions:Personal strength,appreciation of life,relating to others,new possibilities,and spiritual change.The Pearson correlation coefficient was used to meticulously analyze the associations among HADS-Anxiety,HADS-Depression,SOC-13,and CPTGI.Further,univariate and multivariate analyses were conducted to identify factors that affect PTG in patients who underwent intertrochanteric femoral fracture surgery.RESULTS The collected data demonstrated that 67.30%and 60.66%of the 211 patients experienced anxiety and depression,respectively,with overall anxiety levels ranging from mild to moderate and depression levels being mild.The mean SOC-13 score was 55.73±8.81 points,indicating a generally low SOC level.The average CPTGI score was 54.93±9.92 points,demonstrating a relatively low PTG level.Notably,both HADS-Anxiety and HADS-Depression scores were significantly negatively correlated with CPTGI,whereas SOC-13 scores were significantly positively correlated with CPTGI.Univariate and multivariate analyses identified the presence of comorbidities[odds ratio(OR)=2.747,P=0.003],monthly household income(OR=3.292,P<0.001),and exercise habits(OR=4.651,P<0.001)as independent predictors of PTG in patients.CONCLUSION The results of this study indicate a significant negative correlation of anxiety and depression with PTG in patients after intertrochanteric femoral fracture surgery,whereas a significant positive association exists between SOC and PTG.This study helps more comprehensively understand the psychological status and recovery processes of such patients,thereby potentially providing valuable information for clinical practice and psychological interventions.展开更多
Colorectal cancer(CRC)poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the ef...Colorectal cancer(CRC)poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the effects of positive psychological capital(PsyCap)and perceived stress on mediating the social support-PTG relation among 673 CRC patients.Social support,positive PsyCap,perceived stress,and PTG were assessed through questionnaires.The results indicated a direct prediction effect of social support on PTG(LICI=0.481,ULCI=0.644),with the direct effect being 59.5%.Both positive PsyCap and perceived stress exerted a mediating role in the correlation between social support and PTG,with the mediating effects occupying 29.4%(LICI=0.217,ULCI=0.343)and 5.7%(LICI=0.030,ULCI=0.082),respectively.Positive PsyCap further had a chain mediating effect on perceived stress(LICI=0.031,ULCI=0.074),with the chain effect accounting for 5.4%.The total impact of social support on PTG was 100%(LICI=0.882,ULCI=1.008).This model underscores the pivotal role of social support in promoting PTG in CRC patients.Positive PsyCap serves as a crucial mediator in the social support-PTG link,with perceived stress playing a sequential mediating role.Thesefindings suggest that strengthening social support networks and cultivating positive PsyCap may reduce perceived stress and promote the development of PTG in CRC patients.Consequently,intervention programs are recommended to improve the psychosocial well-being of CRC patients.展开更多
Background:Disasters have effects that leave great negative marks on our lives,even after many years have passed.Individuals who experience an earthquake experience physical and psychological difficulties.The purpose ...Background:Disasters have effects that leave great negative marks on our lives,even after many years have passed.Individuals who experience an earthquake experience physical and psychological difficulties.The purpose of this study is to determine how psychological resilience levels affect the feeling of hopelessness and post-traumatic growth in adults who experienced the 06 February,2023 Turkey-Syria earthquake.Methods:Data were collected using the“Personal Information Form(PIF)”,“Turkish forms of Adult Resilience Measure(ARM)”,“Dispositional Hope Scale(DHS)”and“Post-Traumatic Growth Inventory(PTGI)”.In order to determine whether there is a significant difference in the effect of psychological resilience of earthquake victims participating in the study on hope and post-traumatic growth levels in terms of socio-demographic variables,after determining that the data was normally distributed,total score average,minimum and maximum values,standard deviation(SD),independent sample t-test,ANOVA,correlation analysis to determine the relationship between the scales and multiple regression analysis to determine the effect between the scales were performed.Results:Of the 202 earthquake victims who participated in the study,65.8%were between the ages of 18–34,67.3%were female,92.1%were not trapped under the rubble,and 34.2%had second-degree relatives trapped under the rubble.It was determined that 77.8%of them lost their relatives in the earthquake and 77.8%of them lost a serious amount of property and money due to the earthquake.As a result of the analysis,it was determined that psychological resilience had a statistically significant and positive effect on hopelessness and post-traumatic growth in individuals who experienced the 06 February earthquake.In this regard,it has been determined that as the psychological resilience of individuals increases,their hope levels and post-traumatic growth will also increase.Conclusion:Based on the research results,increasing hope and increasing psychological resilience in psychosocial support studies carried out by mental health professionals for traumatic events will contribute to the spiritual recovery of individuals.展开更多
BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has affected mental health and physical health negatively in some individuals.Examining perceived social support and post-traumatic growth(PTG)in COVID-19 pati...BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has affected mental health and physical health negatively in some individuals.Examining perceived social support and post-traumatic growth(PTG)in COVID-19 patients could facilitate our understanding of how patients maintain their mental health.AIM To examine the relationship between the level of perceived social support and PTG in COVID-19 patients discharged from the hospital.METHODS This descriptive study was carried out between August and September 2022 with patients who were hospitalized due to COVID-19 in a university hospital in Erzurum and who were discharged at least 3 mo prior to the beginning of the study.The study was completed by 196 patients.Study data were collected faceto-face using a personal information form,multidimensional scale of perceived social support and PTG inventory.RESULTS The total mean score of the multidimensional scale of perceived social support was 63.82±15.72.The PTG inventory total mean score was 47.77±19.85.In addition,a direct significant correlation was found between perceived social support in COVID-19 patients and PTG.CONCLUSION The study results showed that perceived social support variables affected PTG significantly.Therefore,it is recommended for healthcare professionals to implement interventions to promote social support from healthcare professionals and the patient’s family and friends.Considering the negative effects of the ongoing COVID-19 pandemic,it is very important and necessary to implement effective public health interventions to promote PTG to reduce mental health problems.展开更多
Objective:To study the post-traumatic growth level and influencing factors in patients with maintenance hemodialysis.Methods:A total of 179 patients receiving maintenance hemodialysis from a third-level grade A hospit...Objective:To study the post-traumatic growth level and influencing factors in patients with maintenance hemodialysis.Methods:A total of 179 patients receiving maintenance hemodialysis from a third-level grade A hospital in Tianjin,China were investigated using Post-traumatic Growth Inventory(PTGI),Perceived Social Support Scale,and Medical Coping Modes Questionnaire.Results:The total score for the PTGI was 53.73±16.45.Multiple linear regression analysis showed that social support,coping style,marital status,and family income significantly influenced the post-traumatic growth level in patients undergoing maintenance hemodialysis.These factors explained 41.4%of the variance.Conclusion:Medical staff should help patients under maintenance hemodialysis to fulfill their potentials by boosting the level of social support and to effectively cope with internal conflicts.In addition,nursing staff should provide relevant psychological health education to patients to improve their post-traumatic growth.展开更多
Objective:The purpose of this study was to evaluate the effectiveness of post-traumatic growth(PTG)model-based intervention to improve positive psychological traits in Chinese breast cancer patients.Design:A randomize...Objective:The purpose of this study was to evaluate the effectiveness of post-traumatic growth(PTG)model-based intervention to improve positive psychological traits in Chinese breast cancer patients.Design:A randomized control trial of a psychological group intervention based on PTG model.Methods:The Clinical Trial was registered on 17 August 2019 at Chinese Clinical Trials.gov with Registration number ChiCTR1900025264.A total of 92 patients with breast cancer were recruited.The participants were randomly assigned to the experimental group(n=46)and the control group(n=46).A six-session psychological group intervention based on PTG model was implemented in the experimental group,and a six-session health education was implemented in the control group.The outcomes weremeasured at baseline(pre-intervention),3 weeks,6 weeks after the intervention.The primary outcome was posttraumatic growth assessed by the Chinese version of the Post-Traumatic Growth Inventory(PTGI);Secondary outcomes included psychological resilience,family resilience,rumination,and self-disclosure.Results:A total of 87 patients with breast cancer completed this study,including 44 patients in the experimental group and 43 patients in the control group.There was no significant difference in baseline data of breast cancer patients between the two groups except for the treatment regimen(p>0.05).The two groups were compared after the intervention;the interaction effects between the total scores of posttraumatic growth,family resilience,and self-disclosure and the time term were statistically significant(p<0.05),indicating that the trend of change in total scores of post-traumatic growth,family resilience,and self-disclosure differed between the experimental and control groups over time,and the scores improved in the experimental group were significantly higher than those in the control group.The comparison of psychological resilience and total score of rumination at each time point was statistically significant(p<0.05),indicating that group intervention based on the PTG model could improve the psychological recovery ability and rumination level of the experimental group.Conclusion:The psychological group intervention based on the PTG model significantly improved post-traumatic growth,family resilience,and self-disclosure in patients with breast cancer.However,the impact on psychological resilience and rumination was relatively small.Long-term intervention is needed to further test the effect of the PTG model on psychological resilience and rumination.展开更多
BACKGROUND Breast cancer(BC)is a common cancer among females in Africa.Being infected with BC in Africa seems like a life sentence and brings devastating experiences to patients and households.As a result,BC is comorb...BACKGROUND Breast cancer(BC)is a common cancer among females in Africa.Being infected with BC in Africa seems like a life sentence and brings devastating experiences to patients and households.As a result,BC is comorbid with trauma,post-traumatic stress disorder(PTSD),and post-traumatic growth(PTG).AIM To identify empirical evidence from peer-reviewed articles on the comorbidity trajectories between BC and trauma,BC and PTSD,and BC and PTG.METHODS This review adhered to the PRISMA guidelines of conducting a systematic review.Literature searches of the National Library of Medicine,Scopus,PubMed,Google Scholar,and Scopus databases were conducted using search terms developed for the study.The search hint yielded 769 results,which were screened based on inclusion and exclusion criteria.At the end of the screening,24 articles were included in the systematic review.RESULTS BC patients suffered trauma and PTSD during the diagnosis and treatment stages.These traumatic events include painful experiences during and after diagnosis,psychological distress,depression,and cultural stigma against BC patients.PTSD occurrence among BC patients varies across African countries,as this review disclosed:90%was reported in Kenya,80%was reported in Zimbabwe,and 46%was reported in Nigeria.The severity of PTSD among BC patients in Africa was based on the test results communicated to the patients.Furthermore,this review revealed that BC patients experience PTG,which involves losing,regaining,and surrendering final control over the body,rebuilding a personified identity,and newfound appreciation for the body.CONCLUSION Patients with BC undergo numerous traumatic experiences during their diagnosis and treatment.Psychological interventions are needed in SSA to mitigate trauma and PTSD,as well as promote PTG.展开更多
Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with...Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress disorder.In addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate treatment.Evidence suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress disorder.We performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December 2023.These included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum exosomes.One of these studies had also used whole plasma.Two studies were excluded as they did not involve microRNA biomarkers.Most of the studies had collected samples from adult male Veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult subjects.In measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString panels.Only six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to controls.The miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/exosomes;and miR-18a-3p and-7-1-5p in blood plasma.Several important limitations identified in the studies need to be taken into account in future studies.Further studies are warranted with war veterans and recently traumatized children,adolescents,and adults having PTSD and use of animal models subjected to various stressors and the effects of suppressing or overexpressing specific microRNAs.展开更多
Objectives:This study examines the effectiveness of an eight-week game-based physical activity program designed to reduce post-traumatic stress levels in children affected by the Kahramanmaraş-centered earthquakes tha...Objectives:This study examines the effectiveness of an eight-week game-based physical activity program designed to reduce post-traumatic stress levels in children affected by the Kahramanmaraş-centered earthquakes that occurred in Turkey on 06 February 2023.Following the earthquake,millions of children experienced significant changes in their education and living conditions,adversely affecting their psychological health.Methods:The therapeutic effects of physical activity on post-traumatic stress disorder(PTSD)are frequently emphasized in the literature,and this study specifically focuses on the impact of game-based exercises.The research employed an experimental design,involving 80 earthquake-affected children aged 10 to 13,who were randomly assigned to either an experimental group(n=40)or a control group(n=40).The experimental group participated in game-based physical activities three times per week for eight weeks,with each session lasting 60 min.Data were collected using the Child Post-Traumatic Stress Reaction Index(CPTS-RI),and pre-test and post-test comparisons were conducted.Results:Children in the experimental group showed a marked reduction in PTSD symptoms,with mean CPTS-RI scores decreasing from 2.60 at pre-test to 1.91 at post-test.In contrast,the control group’s scores remained virtually unchanged(2.59 at pre-test vs.2.57 at post-test).Two-way ANOVA demonstrated significant main effects of group and time,as well as a significant group×time interaction(F=114.88,p<0.001,η^(2)=0.42),indicating that the reduction was attributable to participation in the game-based physical activity program.These findings highlight not only the statistical significance but also the practical relevance of structured,culturally adapted physical activity interventions for trauma-exposed children.Conclusion:These findings suggest that regular,structured game-based physical activities can support the mental health of children following traumatic events such as earthquakes and reduce their stress levels.The study recommends integrating physical activity into post-disaster psychosocial support programs and highlights it as an effective,accessible,and enjoyable method to enhance children’s trauma coping skills.Accordingly,it advocates for the wider implementation of physical activity-based interventions in similar crisis situations.展开更多
BACKGROUND Although exposure therapy is a proven treatment for post-traumatic stress disorder(PTSD),empirical research is difficult due to ethical issues.Recently,virtual reality-based content that can provide space a...BACKGROUND Although exposure therapy is a proven treatment for post-traumatic stress disorder(PTSD),empirical research is difficult due to ethical issues.Recently,virtual reality-based content that can provide space and time similar to reality for exposure therapy techniques is increasing.AIM To examine exposure therapy using driving simulations in patients with PTSD due to traffic accidents with PTSD symptoms.METHODS The intervention was provided to two individuals who experienced PTSD symptoms after a traffic accident using a driving simulator.Among the singlesubject experimental designs,the ABA(baseline-intervention-baseline)design was used,and the PTSD checklist and brain wave frequency were used to measure the results.RESULTS In all participants,the standard category departure time of the electroencephalogram decreased from baseline,and PTSD symptoms decreased after the intervention.CONCLUSION These results suggest the potential use of a driving simulator as an exposure treatment tool for PTSD.展开更多
Dear Editor,Post-traumatic stress disorder(PTSD)is a major issue for military personnel,with prevalence rates between 1%and 35%in veterans^([1]),significantly higher than in the general population^([2]).Psychological ...Dear Editor,Post-traumatic stress disorder(PTSD)is a major issue for military personnel,with prevalence rates between 1%and 35%in veterans^([1]),significantly higher than in the general population^([2]).Psychological resources,particularly hope,can protect against PTSD and promote post-traumatic growth^([3]).Hope,conceptualized as both a trait and a state,contributes to well-being and resilience and is negatively associated with PTSD symptoms,representing a psychological factor while mitigating the impact of trauma by fostering resilience and adaptive coping mechanisms.展开更多
Background Post-traumatic stress disorder(PTSD)is a serious mental disorder.Current treatments,typically using serotonin reuptake inhibitors,have limited effectiveness and often cause severe adverse effects.In the pre...Background Post-traumatic stress disorder(PTSD)is a serious mental disorder.Current treatments,typically using serotonin reuptake inhibitors,have limited effectiveness and often cause severe adverse effects.In the present study,we investigated whether Compound B vitamins(VBco)have protective effects in improving PTSD-like behaviors and the possible related molecular mechanisms in a rat model of single prolonged stress(SPS).Methods Eighty adult male rats were randomly divided into four groups(n=20):control(CTRL),SPS,VBco control(CTRL-VBco),and SPS and VBco(SPS-VBco).After modeling,behavioral tests(including open field test,forced swimming test,sucrose preference test,fear conditioning test)were conducted.Blood was collected to detect plasma homocysteine(Hcy)concentrations.Brain tissue was collected for mitochondrial function analysis,western blotting,and quantitative real-time Polymerase Chain Reaction(PCR).Results VBco reduced plasma Hcy levels significantly 1 week post-SPS.The SPS-VBco group showed decreased grooming times and increased movement speed in the open field test,less resting time in the forced swim test,increased sucrose preference ratios in the sucrose preference test,and less freezing time in the fear conditioning test.VBco increased the expression of mRNA for subunits of respiratory chain-related protein in hippocampal mitochondria and improved mitochondrial complex I and IV activity and membrane potential in hippocampus.VBco reversed SPS-induced mtND1 and mtND3 methylation in hippocampal mitochondria.VBco downregulated the levels of methyltransferases(DNMT1,DNMT3A,DNMT3B)in hippocampal mitochondria.Conclusion VBco can inhibit hippocampal mitochondrial DNA methylation effectively.This may be one of the mechanisms by which it attenuates PTSD-like behaviors.展开更多
AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these...AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these patients.METHODS:A total of 280 patients who underwent ocular trauma surgery between January 2023 and January 2024 were selected through convenience sampling.Data were collected using a custom-designed demographic questionnaire,the Connor-Davidson Resilience Scale(CDRISC),the Cognitive Emotion Regulation Questionnaire(C-ERRI),and the PTSD Checklist-Civilian Version(PCL-C).Univariate analysis and stepwise multiple linear regression analysis were performed to determine the factors affecting PTSD in these patients.RESULTS:The average PTSD score for the patients was 33.22±13.48.The scores for individual PTSD dimensions,ranked from highest to lowest,were recurrent traumatic experiences,heightened arousal,avoidance reactions,and social dysfunction.Positive PTSD symptoms were observed in 85 patients(30.36%).Univariate analysis indicated that gender,postoperative vision,marital status,psychological resilience,and rumination were significant factors affecting PTSD symptoms(χ^(2)/t=6.53,17.88,8.83,2.17,and 14.1,respectively;all P<0.05).Pearson correlation analysis showed a positive correlation between rumination and PTSD symptoms(r=0.73,P<0.01)and a negative correlation between psychological resilience and PTSD symptoms(r=-0.14,P<0.05).Stepwise multiple linear regression analysis identified postoperative vision(notably eye removal),rumination levels,and psychological resilience(optimism)as major factors influencing PTSD in these patients(R^(2)=0.57,P<0.001).CONCLUSION:Young and middle-aged patients with open globe injuries have a high incidence of PTSD.Significant risk factors for early PTSD include primary enucleation,high levels of rumination,and low psychological resilience(optimism).Conversely,patients with good postoperative vision recovery,low rumination levels,and high levels of optimism are less likely to develop PTSD.Healthcare providers should pay special attention to patients who undergo primary enucleation,strive to reduce their rumination levels,and enhance their psychological resilience,thereby promoting a positive and optimistic attitude towards their condition and reducing the incidence of PTSD.展开更多
BACKGROUND Hip fracture in elderly patients,particularly those with comorbid post-traumatic stress disorder(PTSD),presents a significant clinical challenge.In addition to the physiological stress of surgery,these pati...BACKGROUND Hip fracture in elderly patients,particularly those with comorbid post-traumatic stress disorder(PTSD),presents a significant clinical challenge.In addition to the physiological stress of surgery,these patients often endure psychological burdens that may adversely affect postoperative recovery.The potential benefits of targeted perioperative psychological interventions have not been fully elucidated in this special population.This study hypothesized that a structured perioperative psychological program would improve recovery outcomes,including postoperative pain,functional outcomes,and mental well-being.AIM To evaluate the impact of perioperative psychological intervention on postoperative outcomes among elderly patients with PTSD undergoing hip fracture surgery.METHODS Between January 1,2022,and December 31,2024,medical records of 50 elderly hip fracture patients(age≥65)with PTSD who underwent surgical fixation at our center were retrospectively reviewed.Patients were divided into an intervention(n=25;standardized psychological care)and control(n=25;usual care)groups.Data collected included demographics,fracture type,PTSD severity,and anesthesia details.The intervention comprised preoperative counseling,relaxation training,and postoperative coping sessions.Postoperative outcomes compared included pain,PTSD severity,activities of daily living scores,complications,length of stay,mental health,and functional recovery.RESULTS The groups had comparable demographic and clinical characteristics.The intervention group demonstrated significantly lower pain scores on postoperative days 3 and 7(P<0.01),fewer moderate-to-severe depressive symptoms(P<0.05),and a greater reduction in PTSD severity(P<0.01)compared with the control group.Furthermore,the intervention group exhibited improved activities of daily living scores at 4 weeks post-surgery and a lower postoperative complication rate(16%vs 32%,P=0.14).The average length of hospital stay was shorter in the intervention group(11.5±2.0 days vs 13.1±2.6 days,P<0.05).CONCLUSION In elderly hip fractures patients with comorbid PTSD,perioperative psychological interventions improved pain control,functional recovery,and PTSD symptoms,supporting its value in holistic perioperative management and outcome enhancement.展开更多
Over one-third of 700,000 military personnel who served in the first Gulf War(GW)suffer from an assortment of symptoms,including cognitive and memory problems,musculoskeletal pain,gastrointestinal discomfort,fatigue,a...Over one-third of 700,000 military personnel who served in the first Gulf War(GW)suffer from an assortment of symptoms,including cognitive and memory problems,musculoskeletal pain,gastrointestinal discomfort,fatigue,and respiratory issues[1,2].The precise etiology of Gulf War illness(GWI)is unclear.However,epidemiological and preclinical studies imply that exposures to the prophylactic drug pyridostigmine bromide,insecticides,pesticides,smoke from oil well fires,and interaction between these exposures and war-related stress underlie this illness[2].As per the Kansas case definition,GWI is a chronic multi-symptom illness displaying one moderately severe and/or multiple symptoms of any severity in at least 3 of 6 symptom domains(fatigue,pain,neurological/cognitive/mood,skin,gastrointestinal,respiratory)[1,2].While the exact pathophysiological changes underlying GWI have not been identified,alterations in immune regulation and dysregulation of the redox balance have been observed in GWI,resulting in chronic systemic inflammation and neuroinflammation[2].展开更多
Background:Facial nerve paralysis in patients occurs in varying degrees of self-image disorders,both physically and mentally,resulting in low self-esteem,anxiety,depression,and even suicide;however,there were few rese...Background:Facial nerve paralysis in patients occurs in varying degrees of self-image disorders,both physically and mentally,resulting in low self-esteem,anxiety,depression,and even suicide;however,there were few researches on psychological problems in facial palsy patients at home and abroad.This study's objective was to investigate post-traumatic growth(PTG)in facial nerve palsy patients and analyze its influencing factors.Methods:Using the convenience sampling method,a total of 47 patients with facial nerve paralysis were enrolled in the current study between June 1,2016,and May 31,2017.Post-traumatic growth rating scale was utilized to investigate the post-traumatic growth of these patients,and factors influencing patients'post-traumatic growth were analyzed through collecting the general sociological information,disease-related information,simple coping style questionnaire,and social support rating scale.Results:The total score of post-traumatic growth in patients with facial nerve paralysis was mean(M)=63.1,standard deviation(SD)=19.14.The ranking of five dimensional scores from high to low was as follows:new possibilities,personal strength enhancement,appreciation of life,mental changes,and improvement of relationships with others.Multiple linear regression analysis showed that six variables,namely,the personality type,duration with facial nerve paralysis,and four coping styles,consisting of three types of positive coping styles and one negative coping style,could explain 71.6%of the total post-traumatic growth score.Conclusions:Post-traumatic growth in facial nerve palsy patients is moderate.The personality type of patients,the disease duration,and the coping style are the primary influencing factors.Therefore,clinical staffs should perform personalized nursing protocol and psychological intervention for facial nerve palsy patients to reduce their negative mood,improve their compliance with treatment,and help them recover more rapidly.展开更多
Objective:This scoping review aims to provide a comprehensive overview of the existing literature on vicarious post-traumatic growth(VPTG)among healthcare professionals and its influencing factors.Methods:Using electr...Objective:This scoping review aims to provide a comprehensive overview of the existing literature on vicarious post-traumatic growth(VPTG)among healthcare professionals and its influencing factors.Methods:Using electronic databases PubMed,PsycInfo,Science Direct,CINHAHL,Web of Science,Scopus,and CNKI,a search was performed for articles on VPTG among healthcare professionals.Relevant articles were included and summarized.Results:This review mapped 29 studies that highlighted positive outcomes of VPTG in healthcare professionals.Factors likely to influence VPTG were identified,such as age,gender,occupation,years of experience,others factors and their importance in understanding well-being.Gaps in the literature,practical recommendations,and future research direction were suggested.Conclusion:This review highlights the nature of research on VPTG and its influencing factors in healthcare professionals.It emphasizes the importance of further research to explore the complex interactions between psychological and physiological responses to vicarious trauma.This review can inform interventions to improve VPTG and support the holistic health of healthcare professionals.展开更多
Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact...Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely unknown.Identifying potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced PTH.In this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term recovery.Results indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury stage.Metabolic kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of PTH.Additionally,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying PTH.Moreover,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for PTH.Future studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.展开更多
Objective:To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods: In this study,we used gi...Objective:To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods: In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil patches.High-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,6-gingerol.Transdermal absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and concentration.Subsequently,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock method.The therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results: The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF levels.Pharmacokinetic experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic efficacy.Conclusions: Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral administration.It can improve PTSD with good patient compliance and ease of administration.Therefore,it is a promising therapeutic formulation for the treatment of PTSD.展开更多
Introduction: Post-traumatic stress disorder (PTSD) is defined as “actual exposure to death or the threat of death, serious injury or sexual violence”, either directly or indirectly, resulting in a symptomatic proce...Introduction: Post-traumatic stress disorder (PTSD) is defined as “actual exposure to death or the threat of death, serious injury or sexual violence”, either directly or indirectly, resulting in a symptomatic procession of repetition, avoidance, neurovegetative hyperactivity and individualized symptoms, with or without negative cognitive and mood changes. It therefore goes without saying that the defence and security forces constitute a high-risk population in need of attention. Objective: To study post-traumatic stress disorder in defence and security forces in the city of Parakou in 2023. Methods: Descriptive cross-sectional study conducted from December 2022 to July 2023. The study population consisted of active military, republican police and firefighters in the city of Parakou in 2023. Non-proportional stratified sampling was used, given the inaccessibility of the source population size for national security reasons. Post-traumatic stress disorder was assessed using the “post-traumatic stress disorder checklist-5 (PCLS-5) scale. Results: A total of 305 subjects participated in the survey. Males dominated 90.2%. The most represented corps was the Republican Police (41.6%), most of whom were non-commissioned officers (46.6%). The majority count between 11 and 20 years of service (48.9%), with 2 to 5 missions completed (67.5%). The calculated prevalence of post-traumatic stress disorder was 11.8%, based on the post-traumatic stress disorder checklist-5 (PCL-5). Of the 36 respondents with post-traumatic stress disorder, 20 (55.6%) had experienced an armed attack, 25 (69.4%) had witnessed a violent death, 18 (50.0%) had witnessed the agony of a colleague, 15 (41.7%) had been exposed to a fire or explosion, while 26 (72.2%) had been traumatized by physical and/or verbal aggression. 5 (13.9%) had consulted a specialist psychiatrist, while 6 (16.7%) were on medication and 26 (72.2%) used sport as a means of maintaining physical and mental health. Respectively 22 (61.1%) and 21 (58.3%) had definite symptoms of anxiety and depression. Multivariate analysis revealed a significant association between post-traumatic stress disorder and the following variables: total number of children ≤ 2 (p = 0.015), comorbidities such as arterial hypertension (p = 0.007), history of hepatitis (p = 0.017), work accidents (p = 0.016), alcohol dependence (p = 0.004), domestic violence (p = 0.004), psychological violence (p = 0.017) and anxiety disorders (p Conclusion: Defence and security personnel can also be prey to post-traumatic stress disorder (PTSD), which needs to be systematically taken into account when they are subjected to trauma in the course of their duties. Mental health should be an integral part of the periodic medical check-up objectives for defence and security forces throughout the country.展开更多
文摘BACKGROUND Postoperative anxiety,depression,irritability,and even fear in patients with intertrochanteric femoral fractures may hinder recovery,compromise treatment efficacy,and impede rehabilitation.AIM To investigate the correlations among anxiety,depression,sense of coherence(SOC),and post-traumatic growth(PTG)in patients who underwent intertrochanteric femoral fracture surgery to improve clinical management strategies and outcomes.METHODS This study carefully selected 211 patients who received surgical treatment for intertrochanteric femoral fractures and were admitted to Dongying People’s Hospital from March 2022 to March 2024.Anxiety and depression in these patients were assessed with the anxiety and depression subscales of the Hospital Anxiety and Depression Scale(HADS),respectively.SOC was evaluated using the 13-item SOC scale(SOC-13),which encompasses three key dimensions:Comprehensibility,manageability,and meaningfulness.PTG was assessed with the Chinese version of PTG Inventory(CPTGI),covering five distinct dimensions:Personal strength,appreciation of life,relating to others,new possibilities,and spiritual change.The Pearson correlation coefficient was used to meticulously analyze the associations among HADS-Anxiety,HADS-Depression,SOC-13,and CPTGI.Further,univariate and multivariate analyses were conducted to identify factors that affect PTG in patients who underwent intertrochanteric femoral fracture surgery.RESULTS The collected data demonstrated that 67.30%and 60.66%of the 211 patients experienced anxiety and depression,respectively,with overall anxiety levels ranging from mild to moderate and depression levels being mild.The mean SOC-13 score was 55.73±8.81 points,indicating a generally low SOC level.The average CPTGI score was 54.93±9.92 points,demonstrating a relatively low PTG level.Notably,both HADS-Anxiety and HADS-Depression scores were significantly negatively correlated with CPTGI,whereas SOC-13 scores were significantly positively correlated with CPTGI.Univariate and multivariate analyses identified the presence of comorbidities[odds ratio(OR)=2.747,P=0.003],monthly household income(OR=3.292,P<0.001),and exercise habits(OR=4.651,P<0.001)as independent predictors of PTG in patients.CONCLUSION The results of this study indicate a significant negative correlation of anxiety and depression with PTG in patients after intertrochanteric femoral fracture surgery,whereas a significant positive association exists between SOC and PTG.This study helps more comprehensively understand the psychological status and recovery processes of such patients,thereby potentially providing valuable information for clinical practice and psychological interventions.
文摘Colorectal cancer(CRC)poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the effects of positive psychological capital(PsyCap)and perceived stress on mediating the social support-PTG relation among 673 CRC patients.Social support,positive PsyCap,perceived stress,and PTG were assessed through questionnaires.The results indicated a direct prediction effect of social support on PTG(LICI=0.481,ULCI=0.644),with the direct effect being 59.5%.Both positive PsyCap and perceived stress exerted a mediating role in the correlation between social support and PTG,with the mediating effects occupying 29.4%(LICI=0.217,ULCI=0.343)and 5.7%(LICI=0.030,ULCI=0.082),respectively.Positive PsyCap further had a chain mediating effect on perceived stress(LICI=0.031,ULCI=0.074),with the chain effect accounting for 5.4%.The total impact of social support on PTG was 100%(LICI=0.882,ULCI=1.008).This model underscores the pivotal role of social support in promoting PTG in CRC patients.Positive PsyCap serves as a crucial mediator in the social support-PTG link,with perceived stress playing a sequential mediating role.Thesefindings suggest that strengthening social support networks and cultivating positive PsyCap may reduce perceived stress and promote the development of PTG in CRC patients.Consequently,intervention programs are recommended to improve the psychosocial well-being of CRC patients.
文摘Background:Disasters have effects that leave great negative marks on our lives,even after many years have passed.Individuals who experience an earthquake experience physical and psychological difficulties.The purpose of this study is to determine how psychological resilience levels affect the feeling of hopelessness and post-traumatic growth in adults who experienced the 06 February,2023 Turkey-Syria earthquake.Methods:Data were collected using the“Personal Information Form(PIF)”,“Turkish forms of Adult Resilience Measure(ARM)”,“Dispositional Hope Scale(DHS)”and“Post-Traumatic Growth Inventory(PTGI)”.In order to determine whether there is a significant difference in the effect of psychological resilience of earthquake victims participating in the study on hope and post-traumatic growth levels in terms of socio-demographic variables,after determining that the data was normally distributed,total score average,minimum and maximum values,standard deviation(SD),independent sample t-test,ANOVA,correlation analysis to determine the relationship between the scales and multiple regression analysis to determine the effect between the scales were performed.Results:Of the 202 earthquake victims who participated in the study,65.8%were between the ages of 18–34,67.3%were female,92.1%were not trapped under the rubble,and 34.2%had second-degree relatives trapped under the rubble.It was determined that 77.8%of them lost their relatives in the earthquake and 77.8%of them lost a serious amount of property and money due to the earthquake.As a result of the analysis,it was determined that psychological resilience had a statistically significant and positive effect on hopelessness and post-traumatic growth in individuals who experienced the 06 February earthquake.In this regard,it has been determined that as the psychological resilience of individuals increases,their hope levels and post-traumatic growth will also increase.Conclusion:Based on the research results,increasing hope and increasing psychological resilience in psychosocial support studies carried out by mental health professionals for traumatic events will contribute to the spiritual recovery of individuals.
文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has affected mental health and physical health negatively in some individuals.Examining perceived social support and post-traumatic growth(PTG)in COVID-19 patients could facilitate our understanding of how patients maintain their mental health.AIM To examine the relationship between the level of perceived social support and PTG in COVID-19 patients discharged from the hospital.METHODS This descriptive study was carried out between August and September 2022 with patients who were hospitalized due to COVID-19 in a university hospital in Erzurum and who were discharged at least 3 mo prior to the beginning of the study.The study was completed by 196 patients.Study data were collected faceto-face using a personal information form,multidimensional scale of perceived social support and PTG inventory.RESULTS The total mean score of the multidimensional scale of perceived social support was 63.82±15.72.The PTG inventory total mean score was 47.77±19.85.In addition,a direct significant correlation was found between perceived social support in COVID-19 patients and PTG.CONCLUSION The study results showed that perceived social support variables affected PTG significantly.Therefore,it is recommended for healthcare professionals to implement interventions to promote social support from healthcare professionals and the patient’s family and friends.Considering the negative effects of the ongoing COVID-19 pandemic,it is very important and necessary to implement effective public health interventions to promote PTG to reduce mental health problems.
文摘Objective:To study the post-traumatic growth level and influencing factors in patients with maintenance hemodialysis.Methods:A total of 179 patients receiving maintenance hemodialysis from a third-level grade A hospital in Tianjin,China were investigated using Post-traumatic Growth Inventory(PTGI),Perceived Social Support Scale,and Medical Coping Modes Questionnaire.Results:The total score for the PTGI was 53.73±16.45.Multiple linear regression analysis showed that social support,coping style,marital status,and family income significantly influenced the post-traumatic growth level in patients undergoing maintenance hemodialysis.These factors explained 41.4%of the variance.Conclusion:Medical staff should help patients under maintenance hemodialysis to fulfill their potentials by boosting the level of social support and to effectively cope with internal conflicts.In addition,nursing staff should provide relevant psychological health education to patients to improve their post-traumatic growth.
基金Funding from the 2018 Postgraduate Research&Practice Innovation Program of Jiangsu Province is gratefully acknowledged(SJCX18_0082).
文摘Objective:The purpose of this study was to evaluate the effectiveness of post-traumatic growth(PTG)model-based intervention to improve positive psychological traits in Chinese breast cancer patients.Design:A randomized control trial of a psychological group intervention based on PTG model.Methods:The Clinical Trial was registered on 17 August 2019 at Chinese Clinical Trials.gov with Registration number ChiCTR1900025264.A total of 92 patients with breast cancer were recruited.The participants were randomly assigned to the experimental group(n=46)and the control group(n=46).A six-session psychological group intervention based on PTG model was implemented in the experimental group,and a six-session health education was implemented in the control group.The outcomes weremeasured at baseline(pre-intervention),3 weeks,6 weeks after the intervention.The primary outcome was posttraumatic growth assessed by the Chinese version of the Post-Traumatic Growth Inventory(PTGI);Secondary outcomes included psychological resilience,family resilience,rumination,and self-disclosure.Results:A total of 87 patients with breast cancer completed this study,including 44 patients in the experimental group and 43 patients in the control group.There was no significant difference in baseline data of breast cancer patients between the two groups except for the treatment regimen(p>0.05).The two groups were compared after the intervention;the interaction effects between the total scores of posttraumatic growth,family resilience,and self-disclosure and the time term were statistically significant(p<0.05),indicating that the trend of change in total scores of post-traumatic growth,family resilience,and self-disclosure differed between the experimental and control groups over time,and the scores improved in the experimental group were significantly higher than those in the control group.The comparison of psychological resilience and total score of rumination at each time point was statistically significant(p<0.05),indicating that group intervention based on the PTG model could improve the psychological recovery ability and rumination level of the experimental group.Conclusion:The psychological group intervention based on the PTG model significantly improved post-traumatic growth,family resilience,and self-disclosure in patients with breast cancer.However,the impact on psychological resilience and rumination was relatively small.Long-term intervention is needed to further test the effect of the PTG model on psychological resilience and rumination.
文摘BACKGROUND Breast cancer(BC)is a common cancer among females in Africa.Being infected with BC in Africa seems like a life sentence and brings devastating experiences to patients and households.As a result,BC is comorbid with trauma,post-traumatic stress disorder(PTSD),and post-traumatic growth(PTG).AIM To identify empirical evidence from peer-reviewed articles on the comorbidity trajectories between BC and trauma,BC and PTSD,and BC and PTG.METHODS This review adhered to the PRISMA guidelines of conducting a systematic review.Literature searches of the National Library of Medicine,Scopus,PubMed,Google Scholar,and Scopus databases were conducted using search terms developed for the study.The search hint yielded 769 results,which were screened based on inclusion and exclusion criteria.At the end of the screening,24 articles were included in the systematic review.RESULTS BC patients suffered trauma and PTSD during the diagnosis and treatment stages.These traumatic events include painful experiences during and after diagnosis,psychological distress,depression,and cultural stigma against BC patients.PTSD occurrence among BC patients varies across African countries,as this review disclosed:90%was reported in Kenya,80%was reported in Zimbabwe,and 46%was reported in Nigeria.The severity of PTSD among BC patients in Africa was based on the test results communicated to the patients.Furthermore,this review revealed that BC patients experience PTG,which involves losing,regaining,and surrendering final control over the body,rebuilding a personified identity,and newfound appreciation for the body.CONCLUSION Patients with BC undergo numerous traumatic experiences during their diagnosis and treatment.Psychological interventions are needed in SSA to mitigate trauma and PTSD,as well as promote PTG.
文摘Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress disorder.In addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate treatment.Evidence suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress disorder.We performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December 2023.These included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum exosomes.One of these studies had also used whole plasma.Two studies were excluded as they did not involve microRNA biomarkers.Most of the studies had collected samples from adult male Veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult subjects.In measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString panels.Only six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to controls.The miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/exosomes;and miR-18a-3p and-7-1-5p in blood plasma.Several important limitations identified in the studies need to be taken into account in future studies.Further studies are warranted with war veterans and recently traumatized children,adolescents,and adults having PTSD and use of animal models subjected to various stressors and the effects of suppressing or overexpressing specific microRNAs.
基金funded by the Scientific Research Projects Unit(BAP)ofİnönüUniversity under project number SBA-2024-3449.
文摘Objectives:This study examines the effectiveness of an eight-week game-based physical activity program designed to reduce post-traumatic stress levels in children affected by the Kahramanmaraş-centered earthquakes that occurred in Turkey on 06 February 2023.Following the earthquake,millions of children experienced significant changes in their education and living conditions,adversely affecting their psychological health.Methods:The therapeutic effects of physical activity on post-traumatic stress disorder(PTSD)are frequently emphasized in the literature,and this study specifically focuses on the impact of game-based exercises.The research employed an experimental design,involving 80 earthquake-affected children aged 10 to 13,who were randomly assigned to either an experimental group(n=40)or a control group(n=40).The experimental group participated in game-based physical activities three times per week for eight weeks,with each session lasting 60 min.Data were collected using the Child Post-Traumatic Stress Reaction Index(CPTS-RI),and pre-test and post-test comparisons were conducted.Results:Children in the experimental group showed a marked reduction in PTSD symptoms,with mean CPTS-RI scores decreasing from 2.60 at pre-test to 1.91 at post-test.In contrast,the control group’s scores remained virtually unchanged(2.59 at pre-test vs.2.57 at post-test).Two-way ANOVA demonstrated significant main effects of group and time,as well as a significant group×time interaction(F=114.88,p<0.001,η^(2)=0.42),indicating that the reduction was attributable to participation in the game-based physical activity program.These findings highlight not only the statistical significance but also the practical relevance of structured,culturally adapted physical activity interventions for trauma-exposed children.Conclusion:These findings suggest that regular,structured game-based physical activities can support the mental health of children following traumatic events such as earthquakes and reduce their stress levels.The study recommends integrating physical activity into post-disaster psychosocial support programs and highlights it as an effective,accessible,and enjoyable method to enhance children’s trauma coping skills.Accordingly,it advocates for the wider implementation of physical activity-based interventions in similar crisis situations.
文摘BACKGROUND Although exposure therapy is a proven treatment for post-traumatic stress disorder(PTSD),empirical research is difficult due to ethical issues.Recently,virtual reality-based content that can provide space and time similar to reality for exposure therapy techniques is increasing.AIM To examine exposure therapy using driving simulations in patients with PTSD due to traffic accidents with PTSD symptoms.METHODS The intervention was provided to two individuals who experienced PTSD symptoms after a traffic accident using a driving simulator.Among the singlesubject experimental designs,the ABA(baseline-intervention-baseline)design was used,and the PTSD checklist and brain wave frequency were used to measure the results.RESULTS In all participants,the standard category departure time of the electroencephalogram decreased from baseline,and PTSD symptoms decreased after the intervention.CONCLUSION These results suggest the potential use of a driving simulator as an exposure treatment tool for PTSD.
基金supported by the Institut de Recherche Biomédicale des Armées(Brétigny-sur-Orge,France).
文摘Dear Editor,Post-traumatic stress disorder(PTSD)is a major issue for military personnel,with prevalence rates between 1%and 35%in veterans^([1]),significantly higher than in the general population^([2]).Psychological resources,particularly hope,can protect against PTSD and promote post-traumatic growth^([3]).Hope,conceptualized as both a trait and a state,contributes to well-being and resilience and is negatively associated with PTSD symptoms,representing a psychological factor while mitigating the impact of trauma by fostering resilience and adaptive coping mechanisms.
文摘Background Post-traumatic stress disorder(PTSD)is a serious mental disorder.Current treatments,typically using serotonin reuptake inhibitors,have limited effectiveness and often cause severe adverse effects.In the present study,we investigated whether Compound B vitamins(VBco)have protective effects in improving PTSD-like behaviors and the possible related molecular mechanisms in a rat model of single prolonged stress(SPS).Methods Eighty adult male rats were randomly divided into four groups(n=20):control(CTRL),SPS,VBco control(CTRL-VBco),and SPS and VBco(SPS-VBco).After modeling,behavioral tests(including open field test,forced swimming test,sucrose preference test,fear conditioning test)were conducted.Blood was collected to detect plasma homocysteine(Hcy)concentrations.Brain tissue was collected for mitochondrial function analysis,western blotting,and quantitative real-time Polymerase Chain Reaction(PCR).Results VBco reduced plasma Hcy levels significantly 1 week post-SPS.The SPS-VBco group showed decreased grooming times and increased movement speed in the open field test,less resting time in the forced swim test,increased sucrose preference ratios in the sucrose preference test,and less freezing time in the fear conditioning test.VBco increased the expression of mRNA for subunits of respiratory chain-related protein in hippocampal mitochondria and improved mitochondrial complex I and IV activity and membrane potential in hippocampus.VBco reversed SPS-induced mtND1 and mtND3 methylation in hippocampal mitochondria.VBco downregulated the levels of methyltransferases(DNMT1,DNMT3A,DNMT3B)in hippocampal mitochondria.Conclusion VBco can inhibit hippocampal mitochondrial DNA methylation effectively.This may be one of the mechanisms by which it attenuates PTSD-like behaviors.
文摘AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these patients.METHODS:A total of 280 patients who underwent ocular trauma surgery between January 2023 and January 2024 were selected through convenience sampling.Data were collected using a custom-designed demographic questionnaire,the Connor-Davidson Resilience Scale(CDRISC),the Cognitive Emotion Regulation Questionnaire(C-ERRI),and the PTSD Checklist-Civilian Version(PCL-C).Univariate analysis and stepwise multiple linear regression analysis were performed to determine the factors affecting PTSD in these patients.RESULTS:The average PTSD score for the patients was 33.22±13.48.The scores for individual PTSD dimensions,ranked from highest to lowest,were recurrent traumatic experiences,heightened arousal,avoidance reactions,and social dysfunction.Positive PTSD symptoms were observed in 85 patients(30.36%).Univariate analysis indicated that gender,postoperative vision,marital status,psychological resilience,and rumination were significant factors affecting PTSD symptoms(χ^(2)/t=6.53,17.88,8.83,2.17,and 14.1,respectively;all P<0.05).Pearson correlation analysis showed a positive correlation between rumination and PTSD symptoms(r=0.73,P<0.01)and a negative correlation between psychological resilience and PTSD symptoms(r=-0.14,P<0.05).Stepwise multiple linear regression analysis identified postoperative vision(notably eye removal),rumination levels,and psychological resilience(optimism)as major factors influencing PTSD in these patients(R^(2)=0.57,P<0.001).CONCLUSION:Young and middle-aged patients with open globe injuries have a high incidence of PTSD.Significant risk factors for early PTSD include primary enucleation,high levels of rumination,and low psychological resilience(optimism).Conversely,patients with good postoperative vision recovery,low rumination levels,and high levels of optimism are less likely to develop PTSD.Healthcare providers should pay special attention to patients who undergo primary enucleation,strive to reduce their rumination levels,and enhance their psychological resilience,thereby promoting a positive and optimistic attitude towards their condition and reducing the incidence of PTSD.
基金Supported by the Shandong Province Medical and Health Science and Technology Development Program Project,No.202204070354.
文摘BACKGROUND Hip fracture in elderly patients,particularly those with comorbid post-traumatic stress disorder(PTSD),presents a significant clinical challenge.In addition to the physiological stress of surgery,these patients often endure psychological burdens that may adversely affect postoperative recovery.The potential benefits of targeted perioperative psychological interventions have not been fully elucidated in this special population.This study hypothesized that a structured perioperative psychological program would improve recovery outcomes,including postoperative pain,functional outcomes,and mental well-being.AIM To evaluate the impact of perioperative psychological intervention on postoperative outcomes among elderly patients with PTSD undergoing hip fracture surgery.METHODS Between January 1,2022,and December 31,2024,medical records of 50 elderly hip fracture patients(age≥65)with PTSD who underwent surgical fixation at our center were retrospectively reviewed.Patients were divided into an intervention(n=25;standardized psychological care)and control(n=25;usual care)groups.Data collected included demographics,fracture type,PTSD severity,and anesthesia details.The intervention comprised preoperative counseling,relaxation training,and postoperative coping sessions.Postoperative outcomes compared included pain,PTSD severity,activities of daily living scores,complications,length of stay,mental health,and functional recovery.RESULTS The groups had comparable demographic and clinical characteristics.The intervention group demonstrated significantly lower pain scores on postoperative days 3 and 7(P<0.01),fewer moderate-to-severe depressive symptoms(P<0.05),and a greater reduction in PTSD severity(P<0.01)compared with the control group.Furthermore,the intervention group exhibited improved activities of daily living scores at 4 weeks post-surgery and a lower postoperative complication rate(16%vs 32%,P=0.14).The average length of hospital stay was shorter in the intervention group(11.5±2.0 days vs 13.1±2.6 days,P<0.05).CONCLUSION In elderly hip fractures patients with comorbid PTSD,perioperative psychological interventions improved pain control,functional recovery,and PTSD symptoms,supporting its value in holistic perioperative management and outcome enhancement.
基金Department of Defense(W81XWH-17-1-0447 and W81XWH1910548 to AKS)Texas A&M University School of Medicine。
文摘Over one-third of 700,000 military personnel who served in the first Gulf War(GW)suffer from an assortment of symptoms,including cognitive and memory problems,musculoskeletal pain,gastrointestinal discomfort,fatigue,and respiratory issues[1,2].The precise etiology of Gulf War illness(GWI)is unclear.However,epidemiological and preclinical studies imply that exposures to the prophylactic drug pyridostigmine bromide,insecticides,pesticides,smoke from oil well fires,and interaction between these exposures and war-related stress underlie this illness[2].As per the Kansas case definition,GWI is a chronic multi-symptom illness displaying one moderately severe and/or multiple symptoms of any severity in at least 3 of 6 symptom domains(fatigue,pain,neurological/cognitive/mood,skin,gastrointestinal,respiratory)[1,2].While the exact pathophysiological changes underlying GWI have not been identified,alterations in immune regulation and dysregulation of the redox balance have been observed in GWI,resulting in chronic systemic inflammation and neuroinflammation[2].
基金Beijing Tiantan Hospital Clinical Foundation for Young Scholars(2017-YQN-35)funded the study.
文摘Background:Facial nerve paralysis in patients occurs in varying degrees of self-image disorders,both physically and mentally,resulting in low self-esteem,anxiety,depression,and even suicide;however,there were few researches on psychological problems in facial palsy patients at home and abroad.This study's objective was to investigate post-traumatic growth(PTG)in facial nerve palsy patients and analyze its influencing factors.Methods:Using the convenience sampling method,a total of 47 patients with facial nerve paralysis were enrolled in the current study between June 1,2016,and May 31,2017.Post-traumatic growth rating scale was utilized to investigate the post-traumatic growth of these patients,and factors influencing patients'post-traumatic growth were analyzed through collecting the general sociological information,disease-related information,simple coping style questionnaire,and social support rating scale.Results:The total score of post-traumatic growth in patients with facial nerve paralysis was mean(M)=63.1,standard deviation(SD)=19.14.The ranking of five dimensional scores from high to low was as follows:new possibilities,personal strength enhancement,appreciation of life,mental changes,and improvement of relationships with others.Multiple linear regression analysis showed that six variables,namely,the personality type,duration with facial nerve paralysis,and four coping styles,consisting of three types of positive coping styles and one negative coping style,could explain 71.6%of the total post-traumatic growth score.Conclusions:Post-traumatic growth in facial nerve palsy patients is moderate.The personality type of patients,the disease duration,and the coping style are the primary influencing factors.Therefore,clinical staffs should perform personalized nursing protocol and psychological intervention for facial nerve palsy patients to reduce their negative mood,improve their compliance with treatment,and help them recover more rapidly.
文摘Objective:This scoping review aims to provide a comprehensive overview of the existing literature on vicarious post-traumatic growth(VPTG)among healthcare professionals and its influencing factors.Methods:Using electronic databases PubMed,PsycInfo,Science Direct,CINHAHL,Web of Science,Scopus,and CNKI,a search was performed for articles on VPTG among healthcare professionals.Relevant articles were included and summarized.Results:This review mapped 29 studies that highlighted positive outcomes of VPTG in healthcare professionals.Factors likely to influence VPTG were identified,such as age,gender,occupation,years of experience,others factors and their importance in understanding well-being.Gaps in the literature,practical recommendations,and future research direction were suggested.Conclusion:This review highlights the nature of research on VPTG and its influencing factors in healthcare professionals.It emphasizes the importance of further research to explore the complex interactions between psychological and physiological responses to vicarious trauma.This review can inform interventions to improve VPTG and support the holistic health of healthcare professionals.
基金supported by the Natural Science Foundation of Guangdong Province,China(2021A1515010897)Discipline Construction Fund of Central People’s Hospital of Zhanjiang(2020A01,2020A02)+1 种基金National Natural Science Foundation of China(31970973,21921004,32271148)Biosecurity Research Project(23SWAQ24)。
文摘Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely unknown.Identifying potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced PTH.In this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term recovery.Results indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury stage.Metabolic kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of PTH.Additionally,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying PTH.Moreover,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for PTH.Future studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.
基金supported by the National Natural Scientific Foundation(82172186)Beijing Natural Scientific Foundation(L222126).
文摘Objective:To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods: In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil patches.High-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,6-gingerol.Transdermal absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and concentration.Subsequently,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock method.The therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results: The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF levels.Pharmacokinetic experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic efficacy.Conclusions: Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral administration.It can improve PTSD with good patient compliance and ease of administration.Therefore,it is a promising therapeutic formulation for the treatment of PTSD.
文摘Introduction: Post-traumatic stress disorder (PTSD) is defined as “actual exposure to death or the threat of death, serious injury or sexual violence”, either directly or indirectly, resulting in a symptomatic procession of repetition, avoidance, neurovegetative hyperactivity and individualized symptoms, with or without negative cognitive and mood changes. It therefore goes without saying that the defence and security forces constitute a high-risk population in need of attention. Objective: To study post-traumatic stress disorder in defence and security forces in the city of Parakou in 2023. Methods: Descriptive cross-sectional study conducted from December 2022 to July 2023. The study population consisted of active military, republican police and firefighters in the city of Parakou in 2023. Non-proportional stratified sampling was used, given the inaccessibility of the source population size for national security reasons. Post-traumatic stress disorder was assessed using the “post-traumatic stress disorder checklist-5 (PCLS-5) scale. Results: A total of 305 subjects participated in the survey. Males dominated 90.2%. The most represented corps was the Republican Police (41.6%), most of whom were non-commissioned officers (46.6%). The majority count between 11 and 20 years of service (48.9%), with 2 to 5 missions completed (67.5%). The calculated prevalence of post-traumatic stress disorder was 11.8%, based on the post-traumatic stress disorder checklist-5 (PCL-5). Of the 36 respondents with post-traumatic stress disorder, 20 (55.6%) had experienced an armed attack, 25 (69.4%) had witnessed a violent death, 18 (50.0%) had witnessed the agony of a colleague, 15 (41.7%) had been exposed to a fire or explosion, while 26 (72.2%) had been traumatized by physical and/or verbal aggression. 5 (13.9%) had consulted a specialist psychiatrist, while 6 (16.7%) were on medication and 26 (72.2%) used sport as a means of maintaining physical and mental health. Respectively 22 (61.1%) and 21 (58.3%) had definite symptoms of anxiety and depression. Multivariate analysis revealed a significant association between post-traumatic stress disorder and the following variables: total number of children ≤ 2 (p = 0.015), comorbidities such as arterial hypertension (p = 0.007), history of hepatitis (p = 0.017), work accidents (p = 0.016), alcohol dependence (p = 0.004), domestic violence (p = 0.004), psychological violence (p = 0.017) and anxiety disorders (p Conclusion: Defence and security personnel can also be prey to post-traumatic stress disorder (PTSD), which needs to be systematically taken into account when they are subjected to trauma in the course of their duties. Mental health should be an integral part of the periodic medical check-up objectives for defence and security forces throughout the country.
