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Analysis of risk factors for post-operative infection following drugeluting trans arterial chemo embolization in hepatocellular carcinoma:A retrospective study
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作者 Gang Wang Rui Qi 《World Journal of Gastrointestinal Surgery》 2025年第6期244-253,共10页
BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment... BACKGROUND Post-operative infection is a common and serious complication following drugeluting trans arterial chemo embolization(D-TACE)in patients with hepatocellular carcinoma(HCC),potentially compromising treatment efficacy and increasing morbidity.AIM To investigate the risk factors associated with post-operative infection in HCC patients undergoing D-TACE,and to provide evidence for clinical prevention and targeted intervention strategies.METHODS Clinical data of 77 primary HCC patients who underwent D-TACE in our hospital from January 2022 to December 2023 were retrospectively analyzed.Patient demographics,laboratory test results,tumor characteristics,and surgery-related parameters were collected.Univariate and multivariate logistic regression analyses were performed to identify risk factors for post-operative infection.RESULTS Post-operative infection occurred in 20 cases(25.97%)among the 77 patients.Univariate analysis showed that age≥65 years,Child-Pugh grade B,tumor diameter≥5 cm,operation time≥120 minutes,preoperative albumin<35 g/L,and comorbid diabetes were significantly associated with post-operative infection(P<0.05).Multivariate logistic regression analysis identified Child-Pugh grade B(OR=2.851,95%CI:1.426-5.698),operation time≥120 minutes(OR=2.367,95%CI:1.238-4.523),and preoperative albumin<35 g/L(OR=2.156,95%CI:1.147-4.052)as independent risk factors for post-operative infection.CONCLUSION Liver function status,operation time,and preoperative albumin level are significant factors affecting post-operative infection in HCC patients undergoing D-TACE.For high-risk patients,enhanced perioperative management,appropriate timing of surgery,and active improvement of nutritional status should be implemented to reduce the risk of post-operative infection. 展开更多
关键词 Hepatocellular carcinoma Drug-eluting trans arterial chemo embolization post-operative infection Risk factors Retrospective study
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Correlation linking illness perception,negative emotions,and the post-operative recovery effect in patients with perianal disease 被引量:2
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作者 Shu-Xiang Hou Feng-Jun Dai +2 位作者 Xian-Xue Wang Shao-Wen Wang Ting Tian 《World Journal of Psychiatry》 SCIE 2024年第11期1718-1727,共10页
BACKGROUND Improvements in the standard of living have led to increased attention to perianal disease.Although surgical treatments are effective,the outcomes of postoperative recovery(POR)are influenced by various fac... BACKGROUND Improvements in the standard of living have led to increased attention to perianal disease.Although surgical treatments are effective,the outcomes of postoperative recovery(POR)are influenced by various factors,including individual differences among patients,the characteristics of the disease itself,and the psychological state of the patient.Understanding these factors can help healthcare providers develop more personalized and effective post-operative care plans for patients with perianal disease.AIM To investigate the effect of illness perception(IP)and negative emotions on POR outcomes in patients with perianal disease.METHODS A total of 146 patients with perianal disease admitted to the First People's Hospital of Changde City from March to December 2023 were recruited.We employed a general information questionnaire,the Brief Illness Perception Questionnaire(B-IPQ),and the Hospital Anxiety and Depression Scale(HADS).We used the 15-item Quality of Recovery Score(QoR-15)to measure patients’recovery effects.Finally,we conducted Pearson’s correlation analysis to examine the relationship between pre-operative IP and anxiety and depression levels with POR quality.RESULTS Fifty-three(36.3%)had poor knowledge of their disease.Thirty(20.5%)were suspected of having anxiety and 99(67.8%)exhibited symptoms.Forty(27.4%)were suspected of having depression and 102(69.9%)displayed symptoms.The B-IPQ,HADS-A,HADS-D,and QoR-15 scores were 46.82±9.97,12.99±3.60,12.58±3.36,and 96.77±9.85,respectively.There was a negative correlation between pre-operative IP,anxiety,and depression with POR quality.The influence of age and disease course on post-operative rehabilitation effect are both negative.The impact of B-IPQ,HADS-A,and HADS-D on POR was negative.Collectively,these variables accounted for 72.6%of the variance in POR.CONCLUSION The quality of POR in patients with perianal disease is medium and is related to age,disease course,IP,anxiety,and depression. 展开更多
关键词 Illness perception ANXIETY DEPRESSION Crissum disease/perianal disease post-operative recovery RELATIVITY
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Effect of ankle versus thigh tourniquets on post-operative pain in foot and ankle surgery 被引量:2
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作者 Ashish Mishra Ahmed Barakat +5 位作者 Jitendra Mangwani Jakub Kazda Sagar Tiwatane Sana Mohammed Aamir Shaikh Linzy Houchen-Wolloff Vipul Kaushik 《World Journal of Orthopedics》 2024年第2期163-169,共7页
BACKGROUND Tourniquets are commonly used in elective extremity orthopaedic surgery to reduce blood loss,improve visualization in the surgical field,and to potentially reduce surgical time.There is a lack of consensus ... BACKGROUND Tourniquets are commonly used in elective extremity orthopaedic surgery to reduce blood loss,improve visualization in the surgical field,and to potentially reduce surgical time.There is a lack of consensus in existing guidelines regarding the optimal tourniquet pressure,placement site,and duration of use.There is a paucity of data on the relationship between the site of a tourniquet and postoperative pain in foot and ankle surgery.AIM To explore the relationship between tourniquet site and intensity of post-operative pain scores in patients undergoing elective foot and ankle surgery.METHODS Retrospective analysis of prospectively collected data on 201 patients who underwent foot and ankle surgery in a single institution was undertaken.Intraoperative tourniquet duration,tourniquet pressure and site,and postoperative pain scores using Visual Analogue Score were collected in immediate recovery,at six hours and at 24 h post-op.Scatter plots were used to analyse the data and to assess for the statistical correlation between tourniquet pressure,duration,site,and pain scores using Pearson correlation coefficient.RESULTS All patients who underwent foot and ankle surgery had tourniquet pressure of 250 mmHg for ankle tourniquet and 300 mmHg for thigh.There was no correlation between the site of the tourniquet and pain scores in recovery,at six hours and after 24 h.There was a weak correlation between tourniquet time and Visual Analogue Score immediately post-op(r=0.14,P=0.04)but not at six or 24 h post-operatively.CONCLUSION This study shows that there was no statistically significant correlation between tourniquet pressure,site and postop pain in patients undergoing foot and ankle surgery.The choice of using a tourniquet is based on the surgeon's preference,with the goal of minimizing the duration of its application at the operative site. 展开更多
关键词 Lower limb surgery Tourniquet time Tourniquet pressure Tourniquet site post-operative pain Pain scores
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Evaluation of Post-Operative Atrial Fibrillation after Cardiac Surgery for Adult Congenital Heart Disease
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作者 Jonathan S.Taylor-Fishwick Nicholas Holzemer +5 位作者 Brandon Middlemist Vivian Duarte Kaitlin E.Olson Johannes Cvon Alvensleben Megan SooHoo Amber Khanna 《Congenital Heart Disease》 SCIE 2024年第5期457-472,共16页
Background:Post-operative atrial fibrillation(POAF)frequently occurs after cardiac surgery.Although adult congenital heart disease(ACHD)patients have higher rates of arrhythmia than the general population,there is sca... Background:Post-operative atrial fibrillation(POAF)frequently occurs after cardiac surgery.Although adult congenital heart disease(ACHD)patients have higher rates of arrhythmia than the general population,there is scant literature on POAF in ACHD patients.Objectives:Identify key risk factors associated with post-operative atrial fibrillation and evaluate the short-and mid-term significance of developing POAF.Methods:A retrospective cohort study was conducted of ACHD patients from 2013–2021 at the University of Colorado Hospital and Children’s Hospital of Colorado.The institutional Society of Thoracic Surgeons(STS)surgical registry was used to identify patients≥18-year-old with congenital heart disease who underwent cardiac surgery during the study period.Results:A total of 168 patients(48%female)were included.The median age was 36 years(IQR 28–48).Onehundred and fifty patients(90%)had moderate ACHD anatomical complexity,and 10 patients(6%)had severe ACHD anatomical complexity based on initial ACHD diagnosis.POAF occurred in 40(24%)patients.Older age,history of supraventricular tachycardia,intra-operative arrhythmia,and post-operative hypokalemia independently predicted POAF.POAF was associated with an increased length of stay(8 vs.5 days,p<0.001)and recurrence of atrial fibrillation(46%vs.21%,OR 3.35,p=0.002)but did not predict mortality,stroke,or bleeding event.Conclusion:Atrial fibrillation is a common complication after cardiac surgery in the ACHD population.Older age,history of supraventricular tachycardia,intra-operative arrhythmia,and post-operative hypokalemia independently predicted POAF.Further investigation is needed to understand the long-term impacts of POAF. 展开更多
关键词 Atrial fibrillation adult congenital heart disease cardiac surgery post-operative complications
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色彩在“One Day Cake”包装设计中的应用研究
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作者 尹文汐 张华斌 《色彩》 2025年第2期44-46,共3页
本文旨在探讨色彩在“One Day Cake”包装设计中的应用研究。通过对色彩心理学、视觉传达理论以及市场调研的综合分析,本文揭示了色彩如何影响消费者的情感体验、购买决策以及品牌形象的塑造。研究发现,合理运用色彩不仅能提升产品的吸... 本文旨在探讨色彩在“One Day Cake”包装设计中的应用研究。通过对色彩心理学、视觉传达理论以及市场调研的综合分析,本文揭示了色彩如何影响消费者的情感体验、购买决策以及品牌形象的塑造。研究发现,合理运用色彩不仅能提升产品的吸引力,还能增强品牌的认知度和忠诚度。本文通过问卷调查、翻阅资料和案例分析,提供了实证支持,并提出了具体的色彩应用策略。研究结果表明,色彩在“One Day Cake”的包装设计中发挥了重要的辅助功能,对品牌传播具有显著的价值。 展开更多
关键词 色彩 One day Cake 包装设计 视觉传达设计
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Determining the differences in O_(3)-NO_(x)-VOCs sensitivity between sauna and roast days
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作者 Yuting Liu Yinghong Wang +9 位作者 Yusi Liu Mengtian Cheng Baoxian Liu Tao Song Bo Hu Dan Yao Miao Yu Yu Shi Guiqian Tang Yuesi Wang 《Journal of Environmental Sciences》 2025年第11期605-614,共10页
Temperature is a key meteorological factor that affects tropospheric ozone(O_(3)),with both humid-heat(sauna days)and dry-heat(roast days)conditions leading to O_(3) exceedances.However,the mechanisms influencing O_(3... Temperature is a key meteorological factor that affects tropospheric ozone(O_(3)),with both humid-heat(sauna days)and dry-heat(roast days)conditions leading to O_(3) exceedances.However,the mechanisms influencing O_(3) formation and degradation under these two weather conditions remain unclear.Therefore,experiments were conducted in Beijing from 2019 to 2021 to observe O_(3),its precursors,and related meteorological elements.A total of 18 days with O_(3) exceedances were selected,including 10 sauna days and 8 roast days.The results of this study revealed that on roast days,the sensible heat flux was 143.5 W/m^(2) greater and the wind speed gradient was 0.018 s^(-1) greater than those on sauna days,indicating more intense thermal and dynamic turbulence.The strong turbulence enhanced the vertical cycle of nitrogen dioxide(NO_(2))and O_(3),resulting in a 58.2μg/(m^(2)·h)increase in NO_(2) upward transport rate and a 1034.4μg/(m^(2)·h)increase in O_(3) downward transport rate on roast days than sauna days.Subsequently,a box model analysis was used to examine O_(3) formation under the two types of weather conditions,revealing that the NO_(2)-O_(3) vertical cycling speed dominated the O_(3) sensitivity.The O_(3) sensitivity was synergistically controlled by nitrogen oxides(NO_(x))and volatile organic compounds on sauna days,while it tended to be NO_(x)-limited on roast days.The aim of this study was to provide a scientific theoretical basis for the control of O_(3) under different types of high temperature weather conditions. 展开更多
关键词 Ozone sensitivity Sauna days Roast days Thermal turbulence Dynamic turbulence
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CNIS holds a series of activities to celebrate World Standards Day
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作者 Fang Luofan 《China Standardization》 2025年第6期20-25,共6页
The World Standards Day(WSD),the big day of global standardizers,is celebrated annually on October 14.Themed“Shared vision for a better world:Spotlight on SDG 17—Partnership for the goals”,this year’s WSD places g... The World Standards Day(WSD),the big day of global standardizers,is celebrated annually on October 14.Themed“Shared vision for a better world:Spotlight on SDG 17—Partnership for the goals”,this year’s WSD places greater emphasis on joint efforts and cooperation for SDGs. 展开更多
关键词 World Standards day Shared Vision Better World Partnership Goals SDG world standards day wsd
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从NIO Day到 躁梦节
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《汽车观察》 2025年第1期89-89,共1页
当蔚来"NIO Day"构建的精密用户自治体系遇上广汽本田"躁梦节"释放的野性生长能量,两种用户运营哲学在此交汇。2017年,蔚来首届"NIO Day"在北京五棵松体育馆惊艳上演,从此成为新势力用户运营的开创性事件。
关键词 用户运营 day NIO
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Stressful factors experienced by patients while waiting vitreo-retinal day surgery:a qualitative study
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作者 Yu Zhang Xiaoqun Fang +3 位作者 Huihong Zeng Jierong Lin Yu Lian Wenmin Huang 《Eye Science》 2025年第1期46-55,共10页
Objective:The day surgery mode has significantly reduced preoperative waiting time for patients.However,this mode also led to brief and sometimes abrupt interactions between patients with vision loss and nursing staff... Objective:The day surgery mode has significantly reduced preoperative waiting time for patients.However,this mode also led to brief and sometimes abrupt interactions between patients with vision loss and nursing staff during the preoperative visits.Additionally,patients may experience negative emotions.The aim of this study was to describe the preoperative experiences and identify related stressful factors among patients waiting vitreo-retinal day surgery.Methods:This study was guided by an interpretive approach.Semi-structured,face-to-face,in-depth interviews were conducted with patients from August 2021 to October 2024.Inductive content analysis and research software were used to analyze the data.Results:Twenty-seven patients agreed to participate the interviews.Their ages ranged from 19 to 70 years old.The waiting time before hospitalization varied from 7 to 90 days.Three main categories emerged from patients’complaints:day surgery procedures,concerns about eye conditions and supports.Conclusions:The findings underscore the importance of preoperative care services.It is suggested that providing accurate preoperative information and effective support can significantly enhance the quality of preoperative care service. 展开更多
关键词 preoperative care stressful factor EXPERIENCE vitreo-retinal day surgery
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My May Day Holiday
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作者 徐芳美 张超(指导) 《中学生英语》 2025年第21期7-7,共1页
I had a three-day holiday for May Day and I went to Qingdao. It was sunny and hot. I had great fun playing in the water. In the afternoon, I went shopping. But there were too many peoplein the market. I didn't rea... I had a three-day holiday for May Day and I went to Qingdao. It was sunny and hot. I had great fun playing in the water. In the afternoon, I went shopping. But there were too many peoplein the market. I didn't really enjoy it.The next day, it was rainy, so I went to a museum. I found a little girl crying in the corner. 展开更多
关键词 SUNNY water May day holiday Qingdao RAINY MUSEUM hot shopping
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电力工控网络0day漏洞风险自动识别技术
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作者 胡朝辉 陈善锋 杨逸岳 《自动化技术与应用》 2025年第1期97-100,共4页
为了准确识别漏洞风险,提出一种电力工控网络0day漏洞风险自动识别方法。将电力工控网络根据需求转换为二维数据,经过归一化处理获取灰度矩阵,采用二维小波阈值去噪方法对数据去噪处理。将常规序列特征提取规则作为基本单元,采用特征提... 为了准确识别漏洞风险,提出一种电力工控网络0day漏洞风险自动识别方法。将电力工控网络根据需求转换为二维数据,经过归一化处理获取灰度矩阵,采用二维小波阈值去噪方法对数据去噪处理。将常规序列特征提取规则作为基本单元,采用特征提取方法提取电力工控网络0day漏洞风险特征,构建特征集合,将集合中的全部数据映射到二维平面上,通过维诺图区分数据,实现电力工控网络0day漏洞风险自动识别。实验结果表明,所提方法可以有效提升漏洞风险自动识别结果的准确性,同时还能够有效缩短识别时间。 展开更多
关键词 电力工控网络 0day 漏洞风险 自动识别
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From fear to triumph:empowering children to overcome anxiety in day surgery:a mini review
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作者 Alaa Ramadan Heba Aboeldahab +4 位作者 Amr Elrosasy Basma Badrawy Khalefa Abdelrahman M.Elettreby Amogh Verma Mohamed E.Almalki 《Frontiers of Nursing》 2025年第3期287-292,共6页
Objective:Pediatric patients undergoing day surgery often experience significant anxiety,which can negatively impact both the child and their parents.Addressing this anxiety is crucial to ensure a smooth surgical expe... Objective:Pediatric patients undergoing day surgery often experience significant anxiety,which can negatively impact both the child and their parents.Addressing this anxiety is crucial to ensure a smooth surgical experience and recovery.This mini review aims to evaluate the impact of preoperative anxiety in children,identify contributing factors,and explore effective strategies to manage this anxiety during day surgery.Methods:A literature review was conducted,focusing on studies that assess anxiety levels in pediatric patients before day surgery and the interventions designed to alleviate this anxiety.The review included both psychological and procedural strategies.Results:Preoperative anxiety in children can be influenced by a variety of factors,including age,previous medical experiences,parental anxiety,and the hospital environment.Untreated anxiety may lead to increased postoperative pain,behavioral changes,and extended recovery times.Several strategies,including psychological preparation,family centered approaches,and the involvement of child life specialists,have been shown to effectively reduce anxiety.Conclusions:Managing anxiety in pediatric day surgery is vital to improving both surgical outcomes and the overall experience for children and their families.Healthcare professionals can play a key role in reducing anxiety through targeted interventions and supportive care. 展开更多
关键词 pediatric anxiety day surgery preoperative preparation parental involvement psychological interventions
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中国式职业教育现代化视域下服装专业群国际化教学创新——基于“One Day Project”教学实践
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作者 李玲 《浙江纺织服装职业技术学院学报》 2025年第2期93-97,F0003,共6页
针对中国高职院校服装专业群国际化教学面临的挑战,推出了一种创新的教学形式——“One Day Project”。教学特点是中外学生跨专业、跨文化合作;教学形式是将服装设计、服装工艺、时尚传媒、时装管理、人物形象、时尚表演等相关专业的... 针对中国高职院校服装专业群国际化教学面临的挑战,推出了一种创新的教学形式——“One Day Project”。教学特点是中外学生跨专业、跨文化合作;教学形式是将服装设计、服装工艺、时尚传媒、时装管理、人物形象、时尚表演等相关专业的师生聚合,同一天共同完成项目目标。这一教学形式不仅提升了学生的国际化视野和创新能力,还提高了教学质量和水平,为培养具备国际竞争力的服装专业人才,为我国职业教育现代化和国际化发展提供了有益探索。 展开更多
关键词 职业教育 服装专业群 One day Project
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Themed event of World Standards Day 2025 held in Beijing
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作者 Jin Jili 《China Standardization》 2025年第6期14-19,共6页
Focusing on“Shared vision for a better world:Spotlight on SDG 17—Partnership for the goals”,the themed event of World Standards Day 2025 was held on October 14 in Beijing.Presided over by Xiao Han,Director-General ... Focusing on“Shared vision for a better world:Spotlight on SDG 17—Partnership for the goals”,the themed event of World Standards Day 2025 was held on October 14 in Beijing.Presided over by Xiao Han,Director-General of Standards Innovative Department of SAMR,the event was attended by Deng Zhiyong,Vice Minister of SAMR and Administrator of SAC,and addressed by Sergio Mujica,ISO Secretary-General,and Jo Cops,IEC President,via videos. 展开更多
关键词 World Standards day Shared Vision Better World Partnership Goals SDG IEC ISO BEIJING
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2025 Cultural Exchange Activity for the Spouses of Diplomats in China A Cultural Kaleidoscope to Celebrate International Women's Day
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《China & The World Cultural Exchange》 2025年第3期16-17,共2页
On March 5,the 2025 Cultural Exchange Activity for the Spouses of Diplomats in China themed“A Women’s Gathering.Stitching a Beautiful World”was held at EVE Castle in Beijing.This event was co-organized by the Spous... On March 5,the 2025 Cultural Exchange Activity for the Spouses of Diplomats in China themed“A Women’s Gathering.Stitching a Beautiful World”was held at EVE Castle in Beijing.This event was co-organized by the Spouses of Diplomats’Club and the Mexican Embassy in China.The wives of Ambassadors from many countries around the world have gathered in Beijing to celebrate International Women’s Day. 展开更多
关键词 spouses diplomats beautiful world international gathering cultural exchange International Womens day event organization beijing cultural exchange activity
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Amplifying Marginalized Voices in Media Coverage of Gender-Based Violence During the 16 Days of Activism in Tanzania
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作者 Khamis Juma Abdalla 《Journalism and Mass Communication》 2025年第3期170-179,共10页
This paper presents the findings of a two-week monitoring project on Gender Based Violence(GBV)in Tanzanian and explores how the media outlets frame the marginalized voices,institutional narratives,and intersectional ... This paper presents the findings of a two-week monitoring project on Gender Based Violence(GBV)in Tanzanian and explores how the media outlets frame the marginalized voices,institutional narratives,and intersectional inclusivity.Drawing qualitative approach and analysis of media coverage of GBV during the 202416 Days of Activism campaign remarkably November 25 to December 10,2024,it reveals the extent that media platforms amplify or marginalize survivor voices.Through two weeks of media monitoring across print,broadcast,and social media including sources notably Mwananchi,TBC1,Cloud FM,and advocacy-driven digital platforms and campaigns through#EndGBVNow and#16DaysOfActivism the study explores recurring themes,language use,tone,and inclusivity.Guided by critical gender theories including Judith Butler’s gender performativity and Gave Tuchman’s symbolic annihilation,the analysis reveals media’s dual role in either perpetuating or challenging patriarchal narratives.Findings indicate that traditional media often foreground prevailing institutional voices while underrepresenting marginalized groups,especially rural women and women with disabilities,portraying harmful cultural practices like FGM and child marriage as community challenges rather than universal human rights violation.Conversely,social media emerged as a transformative space for survivor-led advocacy.Hence the study calls for inclusive,ethical,and survivor-centered media reporting as well as strategic integration of digital and mainstream media to promote justice and policy reform in GBV reporting. 展开更多
关键词 16 days of Activism in Tanzania feminist media studies gender-based violence gender performativity media monitoring media and social justice symbolic annihilation
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青年职场“Gap day”现象探究 被引量:1
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作者 张良驯 付成梅 《中国青年社会科学》 CSSCI 北大核心 2024年第4期11-22,共12页
青年职场“Gap day”现象引起了社会的广泛关注和热烈讨论。青年职场“Gap day”现象的典型特征是:通过语言上的拼贴与再造,表达部分职业青年的困顿疲倦情绪;通过行为上的放空与逃离,排解青年在工作中积攒的情绪和压力;通过价值上的戏... 青年职场“Gap day”现象引起了社会的广泛关注和热烈讨论。青年职场“Gap day”现象的典型特征是:通过语言上的拼贴与再造,表达部分职业青年的困顿疲倦情绪;通过行为上的放空与逃离,排解青年在工作中积攒的情绪和压力;通过价值上的戏谑与自嘲,赋予青年的短暂休息以正向意义。青年职场“Gap day”现象的深层原因是:青年在高压生存环境中的“弹性姿态”、在加速社会运行中的“精神逃离”和在社会时钟齿轮下的“自我审视”。对青年职场“Gap day”现象的有效治理,既要着眼于青年发展,运用公共政策实现青年发展的普遍性诉求,又要立足于青年就业,采取切实措施促进青年实现高质量充分就业。 展开更多
关键词 Gap day 青年现象 青年就业 青年职业发展
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Penehyclidine Hydrochloride Premedication Is Not Associated with Increased Incidence of Post-Operative Cognitive Dysfunction or Delirium:A Systemic Review and Meta-Analysis 被引量:5
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作者 Yuntai Yao Hua Ying +2 位作者 Nengxin Fang Yongbao Zhang Xin Yuan 《Chinese Medical Sciences Journal》 CAS CSCD 2020年第2期121-134,共14页
Objective Post-operative cognitive dysfunction(POCD)and post-operative delirium(POD)are two common post-operative cerebral complications.The current meta-analysis was to systematically review the effects of penehyclid... Objective Post-operative cognitive dysfunction(POCD)and post-operative delirium(POD)are two common post-operative cerebral complications.The current meta-analysis was to systematically review the effects of penehyclidine hydrochloride(PHC)on POCD and POD in surgical patients.Methods Electronic databases were searched to identify all randomized controlled trials comparing PHC with atropine/scopolamine/placebo on POCD and POD in surgical patients.Primary outcomes of interest included the incidences of POCD and POD;the secondary outcomes of interest included peri-operative minimental state examination(MMSE)scores.Two authors independently extracted peri-operative data,including patients'baseline characteristics,surgical variables,and outcome data.For dichotomous data(POCD and POD occurrence),treatment effects were calculated as odds ratio(OR)and 95%confidential interval(Cl).Each outcome was tested for heterogeneity,and randomized-effects or fixed-effects model was used in the presence or absence of significant heterogeneity.For continuous variables(MMSE scores),treatment effects were calculated as weighted mean difference(WMD)and 95%CI.Statistical significance was defined as P<0.05.Results Our search yielded 33 studies including 4017 patients.Meta-analysis showed that,the incidence of POCD in PHC group was comparable to that in saline group(OR=0.97;95%Ck 0.S8-1.64;P=0.92),scopolamine group(OR=0.78;95%CI:0.48-1.27;P=0.32)and atropine group(0R=1.20;95%Ch 0.86-1.67;P=0.29).The incidence of POD in PHC group was comparable to that in saline group(OR=1.53;95%CI:0.81-2.90;P=0.19)and scopolamine group(OR=0.53;95%CI:0.06-4.56;P=0.56),but higher than that in atropine group(OR=4.49;95%CI:1.34-15.01;P=0.01).Conclusions PHC premedication was not associated with increased incidences of POCD or POD as compared to either scopolamine or placebo. 展开更多
关键词 penehyclidine hydrochloride post-operative cognitive dysfunction post-operative delirium META-ANALYSIS
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Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein 被引量:9
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作者 Xi-ming LI Ming-tao SHAO +1 位作者 Jian-juan WANG Yue-lan WANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2014年第10期870-878,共9页
Objective: To investigate the relationship between post-operative cognitive dysfunction(POCD) and regional cerebral oxygen saturation(rSO2) and β-amyloid protein(Aβ) in patients undergoing laparoscopic pancre... Objective: To investigate the relationship between post-operative cognitive dysfunction(POCD) and regional cerebral oxygen saturation(rSO2) and β-amyloid protein(Aβ) in patients undergoing laparoscopic pancreaticoduodenectomy. Methods: Fifty patients undergoing elective laparoscopic pancreaticoduodenectomy received five groups of neuropsychological tests 1 d pre-operatively and 7 d post-operatively, with continuous monitoring of rSO2 intra-operatively. Before anesthesia induction(t0), at the beginning of laparoscopy(t1), and at the time of pneumoperitoneum 120 min(t2), pneumoperitoneum 240 min(t3), pneumoperitoneum 480 min(t4), the end of pneumoperitoneum(t5), and 24 h after surgery, jugular venous blood was drawn respectively for the measurement of Aβ by enzyme-linked immunosorbent assay(ELISA). Results: Twenty-one cases of the fifty patients suffered from POCD after operation. We found that the maximum percentage drop in rSO2(rSO2, %max) was significantly higher in the POCD group than in the non-POCD group. The rSO2, %max value of over 10.2% might be a potential predictor of neurocognitive injury for those patients. In the POCD group, the plasma Aβ levels after 24 h were significantly higher than those of pre-operative values(P〈0.01). After 24 h, levels of plasma Aβ in the POCD group were significantly higher than those in the non-POCD group(P〈0.01). Conclusions: The development of POCD in patients undergoing laparoscopic pancreaticoduodenectomy is associated with alterations of rSO2 and Aβ. Monitoring of rSO2 might be useful in the prediction of POCD, and Aβ might be used as a sensitive biochemical marker to predict the occurrence of POCD. 展开更多
关键词 Laparoscopic pancreaticoduodenectomy Regional cerebral oxygen saturation β-Amyloid protein post-operative cognitive dysfunction
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