In the clinic, the natural recovery rate of homonymous hemianopsia caused by occipital lobe infamtion is low. At present, ideal therapeutic effects of piracetam for improving visual field defects following homonymous ...In the clinic, the natural recovery rate of homonymous hemianopsia caused by occipital lobe infamtion is low. At present, ideal therapeutic effects of piracetam for improving visual field defects following homonymous hemianopsia do not exist. The present randomized, controlled study compared the effects of NeuroAid （MLC601） versus piracetam for improving visual field defects in post-infarct homonymous hemianopsia patients matched for age and sex. After 3 months of treatment with NeuroAid （MLC601） or piracetam, visual field defects were significantly improved, compared with prior to treatment （P 〈 0.001）. After treatment with MLC601, relative reduction of right and left visual field defects was 45% and 45.7%, respectively, while relative reduction after treatment with piracetam was 32.7% and 30.3%, respectively. These findings suggested that MLC601 was superior to piracetam for reducing visual field defects in homonymous hemianopsia patients.展开更多
Surgical intervention for post-infarct ventricular septal defect (VSD) is a challenging procedure due to patients’ complex preoperative conditions. While percutaneous VSD closure can be considered as an alternative t...Surgical intervention for post-infarct ventricular septal defect (VSD) is a challenging procedure due to patients’ complex preoperative conditions. While percutaneous VSD closure can be considered as an alternative to surgical repair, complete closure of the defect remains difficult and is associated with various procedural complications. We report a rare case of a patient with postoperative residual shunts who experienced recurrent stroke episodes, requiring surgical intervention for repair. The patient, a 71-year-old female, developed acute anterior myocardial infarction and post-infarct VSD. Percutaneous closure with a 14-mm Amplatzer VSD occluder device was performed, yet the closure was incomplete. Following discharge, she developed multiple embolic stroke episodes, likely stemming from the residual VSD, which led to the surgical extraction of the device and VSD repair. Fibrous tissue was found to be solely attached to the core and right ventricle side of the device, whilst no fibrous tissue was observed on the side of the left ventricle. The patient has not experienced new neurological symptoms at an 18-month follow-up. Thus, it is paramount to keep in mind that an embolic stroke may occur in the setting of percutaneous post-infarct VSD closure. Surgical repair of VSD with device removal should be considered as a treatment option to such a complex case.展开更多
目的探究血清乙酰胆碱酯酶(AChE)、脂蛋白相关磷脂酶A2(Lp-PLA2)、程序性细胞死亡因子4(PDCD4)表达水平对急性脑梗死(ACI)患者并发卒中后认知功能障碍(PSCI)的评估价值。方法选择2021年12月—2024年2月本院收治的156例ACI患者作为ACI组...目的探究血清乙酰胆碱酯酶(AChE)、脂蛋白相关磷脂酶A2(Lp-PLA2)、程序性细胞死亡因子4(PDCD4)表达水平对急性脑梗死(ACI)患者并发卒中后认知功能障碍(PSCI)的评估价值。方法选择2021年12月—2024年2月本院收治的156例ACI患者作为ACI组,同期选取体检健康者156名人员作对照组。根据简易精神状态检查(MMSE)评分,将患者分为PSCI组(62例)与非PSCI组(94例)两组。比较各组血清AChE、Lp-PLA2、PDCD4表达水平。采用受试者工作特征(Receiver operating characteristic,ROC)曲线分析血清AChE、Lp-PLA2、PDCD4水平对ACI并发PSCI的评估价值。多因素logistic回归分析影响ACI并发PSCI的因素。结果ACI组血清AChE、Lp-PLA2、PDCD4水平比对照组高(P<0.05)。PSCI组血清AChE、Lp-PLA2、PDCD4水平比非PSCI组高,MMSE评分比非PSCI组低(P<0.05)。AChE、Lp-PLA2、PDCD4评估患者并发PSCI的曲线下面积(Area under the curve,AUC)是0.786(95%CI:0.712~0.860)、0.769(95%CI:0.691~0.846)、0.758(95%CI:0.679~0.837),三者联合检测的AUC为0.905(95%CI:0.861~0.949),联合检测的AUC高于单独检测(Z=2.679、3.004、3.186,P<0.05)。logistic分析显示,血清AChE、Lp-PLA2、PDCD4是ACI患者并发PSCI的危险因素(P<0.05)。结论ACI并发PSCI患者血清AChE、Lp-PLA2、PDCD4表达水平较高,三者联合对ACI并发PSCI的诊断效能较高,可能是评估ACI并发PSCI的血清指标。展开更多
文摘In the clinic, the natural recovery rate of homonymous hemianopsia caused by occipital lobe infamtion is low. At present, ideal therapeutic effects of piracetam for improving visual field defects following homonymous hemianopsia do not exist. The present randomized, controlled study compared the effects of NeuroAid （MLC601） versus piracetam for improving visual field defects in post-infarct homonymous hemianopsia patients matched for age and sex. After 3 months of treatment with NeuroAid （MLC601） or piracetam, visual field defects were significantly improved, compared with prior to treatment （P 〈 0.001）. After treatment with MLC601, relative reduction of right and left visual field defects was 45% and 45.7%, respectively, while relative reduction after treatment with piracetam was 32.7% and 30.3%, respectively. These findings suggested that MLC601 was superior to piracetam for reducing visual field defects in homonymous hemianopsia patients.
文摘Surgical intervention for post-infarct ventricular septal defect (VSD) is a challenging procedure due to patients’ complex preoperative conditions. While percutaneous VSD closure can be considered as an alternative to surgical repair, complete closure of the defect remains difficult and is associated with various procedural complications. We report a rare case of a patient with postoperative residual shunts who experienced recurrent stroke episodes, requiring surgical intervention for repair. The patient, a 71-year-old female, developed acute anterior myocardial infarction and post-infarct VSD. Percutaneous closure with a 14-mm Amplatzer VSD occluder device was performed, yet the closure was incomplete. Following discharge, she developed multiple embolic stroke episodes, likely stemming from the residual VSD, which led to the surgical extraction of the device and VSD repair. Fibrous tissue was found to be solely attached to the core and right ventricle side of the device, whilst no fibrous tissue was observed on the side of the left ventricle. The patient has not experienced new neurological symptoms at an 18-month follow-up. Thus, it is paramount to keep in mind that an embolic stroke may occur in the setting of percutaneous post-infarct VSD closure. Surgical repair of VSD with device removal should be considered as a treatment option to such a complex case.
文摘目的探究血清乙酰胆碱酯酶(AChE)、脂蛋白相关磷脂酶A2(Lp-PLA2)、程序性细胞死亡因子4(PDCD4)表达水平对急性脑梗死(ACI)患者并发卒中后认知功能障碍(PSCI)的评估价值。方法选择2021年12月—2024年2月本院收治的156例ACI患者作为ACI组,同期选取体检健康者156名人员作对照组。根据简易精神状态检查(MMSE)评分,将患者分为PSCI组(62例)与非PSCI组(94例)两组。比较各组血清AChE、Lp-PLA2、PDCD4表达水平。采用受试者工作特征(Receiver operating characteristic,ROC)曲线分析血清AChE、Lp-PLA2、PDCD4水平对ACI并发PSCI的评估价值。多因素logistic回归分析影响ACI并发PSCI的因素。结果ACI组血清AChE、Lp-PLA2、PDCD4水平比对照组高(P<0.05)。PSCI组血清AChE、Lp-PLA2、PDCD4水平比非PSCI组高,MMSE评分比非PSCI组低(P<0.05)。AChE、Lp-PLA2、PDCD4评估患者并发PSCI的曲线下面积(Area under the curve,AUC)是0.786(95%CI:0.712~0.860)、0.769(95%CI:0.691~0.846)、0.758(95%CI:0.679~0.837),三者联合检测的AUC为0.905(95%CI:0.861~0.949),联合检测的AUC高于单独检测(Z=2.679、3.004、3.186,P<0.05)。logistic分析显示,血清AChE、Lp-PLA2、PDCD4是ACI患者并发PSCI的危险因素(P<0.05)。结论ACI并发PSCI患者血清AChE、Lp-PLA2、PDCD4表达水平较高,三者联合对ACI并发PSCI的诊断效能较高,可能是评估ACI并发PSCI的血清指标。
